4.平成 20年 6月 19日 - WAM NET（ワムネット）
Contents
1. NHL DEET DEET DEET2. 1
3. DEET 1 4 _ P070261 s DEET m 70 vol am Crl CD SD m 7 a 10 70 DEET 60 mg kg DEET 300 mg kg
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17. 15 2 4 11 12 129 A B 24 2
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19. 5 6 7 532 72 gt 7 7 8 3 4 S
20. 183 26 56 12 WT lt DEET McGready R et al Safety of the insect repellent N N diethy M toiuamide DEET in pregnancy Am J Trop Med Hyg 2001 65 4 285 9 Roy M J Randomized Controlled Trial of Combination Treatment with Pyridostigmin DEET and Teremethrin July 2005 Pyridostigmine diethyltoluamide permethrin and stress a double blind randomized placebo controlled trial to assess safety Mayo Clin Proc 2006 Oct 81 10 1303 10 McDuffie HH Pahwa P Robson D at al Ins ct repellents phenoxyherbicide exposure and non Hodgkin s lymphoma Joumal of Occupational and Environmental Medicine 47
21. FDA EPA IDEET DEET EPA FDA FDA http a257 g akamaitech net 7 257 24422 01jan20071 800 edocketaccess gpo gov 2007 pdf E7 2890 pdf EPA http a257 g akamaitech net 7 257 24422 0 jan20071 800 edocket access gpo gov 2007 pdf E7 3008 pdf
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27. C DEET 24 24 Gerald B Kasting et al A Spreadsheet Based Method for Estimating the Skin Disposition of Volatile Compunds Application to N N Diethyi m Toluamide DEET J Occup Enviraon Hyg Vol 5 No 10 Page 633 644 Brand RM Jendrzejewski JL Chronic ethanol ingestion aters xenobiotic absorption through the skin potential role of oxidative stress 1 DEET DE
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29. 1 10 1 5 DEET DEET 1 DEET Bartlett 3
30. 3 05 02 9 17 6 1 2 3 4 5 6 10 11 EE 1 3 NR 22 2 or RRB 1 24 1 a 2 Ni 3 4 py A ML Sceee 5 5 a 7 NIS 9 Oe a 10
31. 10 20 9 10 3 1 1 0 91 4g 20 6 5 4 3 2 1 0 B D F I J M N Q 1 i 11 15 21 4 re
32. LPG LPG p 426 50 6 1 30 1 2 2 1 2 5 3 0 2 30 3 2 2
33. 5 ED ER ELE TE TE OE TET lt
34. DEET LC MS MS 28 Tmax DEET 1 7h 2 3 h DEET 3 0 h 1 7 h 28 Cmax DEET 455 ngmL 481 ng mL DEET 2020 ng mL 1670 ng mL 28 AUC 4 DEET 3050 ng mL 2970 ng hmL DEET DD 21400 ng MmL 16000 ng hmL DEET LC MS MS 28 Tmax 8 0h 4 0h 28 Cmax 111 ngmL 183 ng mL 28 AUC 4 1820 ng h mL 2740 ng h mL Cmax AUCo 4
35. 8 3 i B
36. DEET hd 0 DEET Schofield S Tepper M Gadawski R Laboratory and field evaluation of the impact of exercise on the performance of regular and polymer based deet repellents J Med Entomol 2007 Nov 44 6 1026 31 Kasting GB Bhatt VD Speaker TJ Microencapsulation decreases the skin absorption of N N diethy m toluamide DEET Toxicol In Vitro 2008 Mac22 2 548 52 Epub 2007 Nov 9 Ditzen M Pellegrino M Vosshali LB Insect odorant receptors are molecular targets of the insect repellent DEET Science 2008 Mar 28 319 5871 1838 42 Epub 2008 Mar 13 Y G Gil ii et al Mosquito repellent activity of essential oils of aromatic plants growing Argentina Bioresource Technology 99 7 2507 2515 2008 5 JF CARROLL et al Twelve hour duration testing of cream formulations of three repellents
37. 6 Wa b 1 3 gt 3 1 6 8 2 0 0 12
38. eR 0 21 27 9 _ 2
39. DEET in vitro DEET DEPA DEET DEET DEPA DEET in vitro 3 DEET IR3535 KBR3023 DEET 3
40. 3 9 0 9
41. EPA DEET DEET
42. 0 12 lt e 12 e e
43. PIO NET 2000 _ 20 2005 4 30 2 MPP
44. 2 mm NO 10 14 4 0 2 0 4m 9 a
45. DEET triclosan asetaminophen ADI 100 DEET DEET 301 DEET 83 4 DEET DEET
46. 4 2 DT OL ET 3 EEE ETE
47. 3 Ds 6 I N P M
48. 1 2 8 3 lt 2
49. 0 5 12 1g 0 4 2 7g 0 2 3 9g 1 D 5 2g _ 8 15 40 g x J M g 3 9 5 2 3 6 2 0 1 5 1 3 1 4 1 0 lt gt XX 8 20 2 9
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55. Schoenig GP Hartnagei RE Jr Schardein JL et a Neurotoxicity Evalution of N N Diethy m toluamide DEET in Rats FUNDAMENTAL AND APPHED TOXICOLOGY 21 355 365 1993 TRS TOXICOLOGY REGULATORY SERVICES LISTING OF COMPLETED STUDIES FOR THE DEET TOXICOLOGY DATA DEVELOPMENT OROGRAM SUMMARY OF COMPLETED STUDIES ON DEET SUMMARY AND OVERVIEW OF THE DEET TOXICOLOGY DATA DEVELOPMENT PROGRAM 1999 Hoy JB Cornell JA Karlix JL et al Repeated coadministrations of pyridostigmine bromide DEET and permethrin alter locomotor behavior of rats Veterinary and human toxicology 42 72 76 2000 DEET Pyridostigmine Bromide PB Permethrin PERM 7 DEET 200mg kg day PB 7 5mg kg day PERMW 60mg kg day DEET 1 day PB 3 75mg kg day DEET Oooneh kg day PERW 30mg kg day Pyridostigmine Bromid PB 1 3mg kg day DEET 40mg kg day Permethrin PERM 0 3mg kg day A A
56. 2 4 6 10cmI 9 10 15cm
57. gt 1 mr 1 1 2 3 3 2 1 100mL 41
58. 12 100g 12g 4 11 100g 4 11g 6 g 100g 6 2 We H bh SS 6 g 100g g 100m1 4 4 1 3
59. DEET 28 DEET DEET DEET DEET 1 DEET 1 DEET
60. 6 4 5 1 3 i 2003 10
61. 4 5 10cr his 100ml 12g GE 7 D e 7 FF UE OPEN
62. DEET RTS DEET DEET 89 2003 2 DEET DEET DEET DEET
63. Q R 9 5 10 15cm 100 80 60 40 20 0 A B C D EFGH1 I JKL MNOPQR 7 3
64. 42 6 56 7 3 91 8 it 6 2 4 11 _ 15 13 ot a A A
65. 3 1 26 20 8 1 1
66. repellent and sunscreen preparations British Jounal of 1 DEET dermatology 152 1263 1267 2005 3 DEET DEET 3 E masry Eman M et al interaction of pyridostigmine DEET bromide and N N diethy m toluamide alone and in P P gp Santhanam A Miller MA Kasting GB Absorption and evaporation of N N diethyI m toluamide from human skin in vitro Toxicoiogy and Applide Pharmacology 204 81 90 2005 3 combination with P glycoprotein expressed in P gp Escherichia coli leaky mutant Journal of toxicology and DEET
67. 4 2 LY TY UA Bal A _ eo 3 CR C AAACXFL 53 RstH80 lt 6 Gmg ke PUDY5Tscm 3 ss 5 hy RRDNE BC 2 10 20 2 a oln lmlo 10 Tv lr i 15cw 4 10 15cm lt
68. 2 3 22 16 1 2 2 B 1 20kg N Q 2350cm 6 3 4g Week 1 1 571 4mg
69. 3 1 3 1 3 2 1g 1 0 06 0 07g 1 2 a 5 2 7 7 D 70 39 63 6 _ 8 9
70. 6 1 20 _ 217 81 4 1 99 1 90 8 62 5 2 4 6 6 6 1 2
71. Dunnett 1 5 Steel 1 5 DEET DEET F 3 1 5 Welch 1 5 2
72. 2 10cm 10 44 m RTS500 25C 22C 29 RH 10cm 24 30 3 5 16 20 8 2 3
73. 2004 10 11 2004 11 2005 3 3 1 4 109 12 sd CN 6 _ 2
74. lt 9 Wc 3 4 8 8
75. 1 2 3 C in 7 xX x7v LC TE TEA ki lt MS2P gt ER re 3 LU TC CC LLT DIV DDS F gt Lo ze yy lt gk
76. Zo Science 2008 Mar 14 319 5869 1471 DEET LL L Neuroscience Hiding from biting insects in plain DEET scent Lesiie M 104 DEET Enhanced skin absorption and fly toxicity of permethrin in emulsion formulation Bull Environ Contam Toxicol 2007 May 78 5 299 303 Epub 2007 Ju 10 DEET In search of a better mosquito repellent Environ Health Perspect 2008 Aug116 8 A337 10 David O Freedman et al Malaria Prevention in Short Term travelers The NEW ENGLAND JOURNAL of MEDCINE 359 6 603 612 2008 8 SCOTT P CARROLL Prolonged Efficacy of iR3535 Pepellents Against Mosquitoes and Blacklegged Ticks in Noth America J Med Entomo 45 4 706 714 2008 6 8 1587 1590 2008 Preventing mosquito borne infections Prescrire Int 2008 Dec 17 98 250 253 Dee
77. 7 Ge la 3 Uy 5 AN 9 2 3 90 8 62 5 2
78. Wilcoxon rank sum test 1 3 DEET DEET 60 1 8 P070261 mg kg 3 27 29 DEET 300 mgkg 10 9 29 DEET 10 6 29 DEET DEET 8 28 DEET 22 28 DEET 18
79. 1 17 6 3 2 17 8 15 40
80. 4 6 A E PS EE lt gt 5 MU X lt 9 15cm
81. inclined plane performance forepaw grip time beam walk scores beam walk time DEET CA1 lt CA1 CA3 DEET 50 200 500mg kg DEET 1000 2000 5000ppm DEET500mg kg 5000ppm DEET 50 200 500mg kg DEET 1000 2000 5000ppm
82. 0301 259X 35 5 page179 184 2005 09 Protecting against insect bites US Pharmacist USA 2006 Vol 31 pp72 74 77 EBM DEET EBM EBM 1345 1898 8 4 page514 519 2007 06 1 DEET 2030 6 DEET 20 permethrin ethanol DEET eb
83. EE maa 6 8 1mj 35mg 7F3 Il 16 29 lt gm EE ri EE 1 1 9 2 3 ET 1
84. 1 1 _ YR A Siz US LPG _ RS 100rml 3Oml 5 1 mo 67 2216 9 T 7 43
85. DEET DEET DEET DEET DEET Abou Donia MB Goidstein LB Dechovskaia A et ak IDEET 4 40 400mg kg Effects of daily dermal application of DEET and epermethrin alone and in combination on sensorimotor performance blood brain barrier and blood testis BBB barrier in rats DEET
86. 2 4 6 3 42 6 56 7 3 _ 91 8 1 ES 21 0 ERROR 2 3 1 35 7 9 0 20 40 60 80 100 3 3 4 3 97 74 4 9 5
87. 2 250m1 100m1 5 GC 16 110cm 5
88. 2 2 3 15 2 UL 30 1 1 2 3 4 1 2 10kg 5g 5mL 4 3 31 37 4
89. EPA 6 6 12 TT 25 7 1 6 2 3
90. DEET N N diethy phenylacetamide DEPA dimethy lphthalate DMP DEET DEPA DEET DMP DEPA DEET benzyi benzoate dibutyl phthalate DEET carvone 2 DEET IR3535R
91. 2 es 2 2 1 RTECS 1992 2 Poisindex 1992 3 Medica1 Toxico1ogy 1988 4 I10 1992 32 38 DEET 1 N N diethyl 3 methylbenzamide N N diethyI m toluamide DEET CHNO 191 26 Qi CAS No 134 62 3 CONCHhCHhjp 2 37 2 55 1 400 1 400 1 17
92. 2 D FU 190mg 910cm 6 002me 6 8 10 15cmM cm S10crn 3 UT FU A AI2 lt DII eT 5 6 NNwNN 7 40 507 gt 100 1 t
93. 5 5 2 12 10 3
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95. 5 8 NO 8 6 1 17 8 15 16 00 18 00 5 6 8 1 2 3 RT lt gt lt a ha No N
96. 2002 6 12 0 20 40 60 80 100 5 6 12 2 3 1 4 11 100 3 50 1 2 1
97. 12 DEET KBR3023 Pirimiphos methy Deltamethrin pyrethroid Deltamethrin pyrethroid propoxur DEET DEET A sinensis3 A_archangelica1 2 ligustilide DEET DEET BioUD BioUD 7 15 DEET
98. B Abde Rahman A Abou Donia S E Masry E Shetty A Abou Donia M Stress and combined exposure to low doses of pyridostigmine bromide DEET and permethrin produce neurochemical and neuropathological 21 alterations in cerebral cortex hippocampus and cerebellum J Toxicol Environ Health A 2004 Jan 23 B 67 2 163 92 IAntwi FB Shama LM Risk assessments for the insect repelients DEET and picaridin Regul Toxicol Pharmacol 2008 Jun 51 1 31 6 Epub 2008 Mar Deborah E Kel et ai NN Diethy m Toluamide DEET Suppresses Humoral 1mmunological Function in B6C3F1 Mice oxicological Scjences 108 Evidence for inhibition of cholinesterases in insect and mammalian nervous systems by the insect repelient deet BMC Biology 2009 7 47doi 10 1186 1741 7007 7 47 DEET picaridin DEET NOEL
99. m Day 1 11 LTK a Day 28 100000 Male 100000 Temale 60 mgkgday dermal 60 mgkg day dermal 300 mg kg day dermal 300 mgkgday dermal 10000 72mgbody day implant subcutaneousiY 10000 C 72mghbody day implant subcutaneously 1000 1000 3 8 8 100 A 10 8 10 10 Al 1 1 12 12 me h e bh ms 3 a 16000 1 2 msTK m Day 28 60 mg kg DEET Pr 111 1820 1 7 455 3050 185 2740 2 3 481 2970 m 60 300 mg kg 7 2 mg body day AUC 60 mg kg 3 DEET 4 4 P070261 2008 7 10 4 P070261 1 de El ee 2 0 3 2 3 22 5 3 23
100. 12 0 8 mg cm Sd 0 4 0 2 0 0 6 B DD F Il J MM N a 12 5 1 8 4 B 20kg 5 N Q 2350cm
101. 11 DEET Decrease in DEET repellency caused by nitric oxide in Rhodnius prolixus Arch insect Biochem Physiol 2008 Jan 67 1 1 8 Zainulabeuddin Syed et al Mosquitoes smell and avoid the insect repellent DEET DEET Proc Natl Acad Sci USA VolL105 No 36 Page 13598 13603 2008 09 09 12 2 1 1 7 8 lt 2 1 gt NO 1 1 NO 2 lt Ne RE 3 NO 3 4 NO 4 DEETL oo 3 9 NO 5 DEET 9 4 4 NO 6 DEET WE CE a 46 NO 7 DEET
102. 7 75 T 7 A Tk 5 x Te EDN DE OO 0PEN 1 fas 5 8 1
103. 80 5 Hew ett Packard 5890 series I FID CBP 1 25 050 0 32 mm 25 m 0 50 um 250 250 100 1 min 20 min 250 C 2 min 10 psi 1 min 2 1 lt gt 40cmX40cm 15 23 29 15 lt gt 15cmX20cm
104. 950mg kg 4 750mg kg 1 679mg kg 950mg kg 1 33 100 50mL 2 3 570mg kg 1 6 10mL kg 3 6mL kg 2 30 2 8 100 9 10 JNN 2
105. 3 5 1 a
106. 200mg kg DEET 2 59mg kg day DEET NOEL B6C3F1 DEET 0 7 7 15 5 31 62mg Kg 14 DEET DEET in vitro DEET DEET IR3535 DEET R3
107. 4 2 DEET 2 10 560 30 96 0 50 222 2 LPG 20 100mL
108. DEET DEET po pi deTltamethr in pyrethroid DEET pyrethroid LD50 8 Thorsell W Repelling properties of some plant matenals on the tick Ixodes ricinus Phytomedicine 2006 6 132 4 Tsukamoto Toshihiko et al Comparison of larvicidal aduiticidal and acaricidal activity of two geometrical butylidenephthalide isomers Biologicai amp pharmaceutical bulfetin 2006 29 3 592 4 Williams C R Mosquito repellents in frog skin Biology Letters 2006 2 2 242 5 Xue Rui De et al Laboratory evaluation of 21 insect repellents as larvicides and as oviposition deterrents of Ae
109. 6 3
110. Absorption distribution metabolism and excretion of N N diethy M toluamide in the rat Drug Metabolsm 2 and Disposition 24 156 163 1996 PR i Qiu H et al Pharmacokinetics of insect repeilent NE DEET diethy m toluamide in beagle dogs following intravenous and topical routes of administration J Pharm Sci 1997 86 4 514 6 Choi J Hodgson E Rose RL Inhibition of trans OEET permethrin hydrolysis in human liver fractions by chiloropyrifos oxon and carbaryl Drug Metabolism and Drug Interactions 20 233 246 2004 k X Gu T Wang D m Collins et at In vitro evalition of concurrent use of vommericalky available insect
111. Miot HA Batistella RF Batista Kde A et al Comparative study of the topical effectiveness of the Andiroba oil Carapa guianensis and DEET 50 as repellent for Aedes sp Revista do Instituto de Medicina Tropical de Sao Paulo 46 253 256 2004 Andiroba oi1 DEET Andiroba oil DEET Negm AY lbrahim IR E Temsahy MM et al Effect of topical agents on cercariae of Schistosoma mansoni free DEET control release DEET control release DEET Joural of Egyptian Society of Parasitology 34 903 913 2004 Bernier UR Furman KD Kiine DL et ak Comparison of Catnip oil Nepetalactone contact and spatial repellency of catnip oil and N N diethyl 3 methylbenzamide deet against mosquitoes IDEET
112. JI7 a amp a N em 8 2 1 5 8 1 2 lt 0 02mg j 8 1 1 ml 2 cm gt wx 3 ES 6 O 3 1 129
113. 1 4 6 58 1 3uj 2
114. 6 2 Q amp A 3
115. NHL DEET 20764 DEET DEET 1993 1997 1995 2001 DEET Registry 296 DEET 36 157 19 41 42
116. 4 wD Sls NPBB gran IE es We 9 9 2 18 3 EE RE NT ED EE 9 500mg 72hr 3 1
117. DEET DEET DEET DEET DEET DEET DEET DEET DEET DEET NPTN DEET
118. m m m m m TK m 1 3 D27 29 5 10 D9 29 4 10 D6 29 0 0 0 1 2 0 5 1 m T Day 28 gs 1 Day 8 28 1 Day 22 28 Day 18 1 m 1 y 4 6 9 2 a CA1 3 a sm m
119. 571 mg 2 571 4 x mg 8 MN B D F 1 J MN qa y gt 13 23 7 1 27 47 15 27 Wy 1 6
120. DEET 7 0 5 DEET 47 Sreeneeranj Kasichayanula et al Percutaneous DEET oxybenzone characterization of the insect repellent DEET andthe in vivo DEET sunscreen oxybenzone from topical skin oxybenzone application Toxicol Appl Pharmacol 2007 Sep DEET 1 223 2 187 94 oxybenzone Abu Qare AW Abou Donia MB jn vitro metabolism and interactions of pyridostigmine bromide N N diethy m toluamide and permethrin in human plasma and liver microsomal enzymes 93 Xenobiotica 2008 Mar38 3 294 313 Pyridostigmine bromide PB DEET Permethrin PB Permethrin DEET
121. 10cm AS Pp ek Mu 4 10ce wz y sr 10cm 1 K40 2 3 gt 1 7 3
122. 2350cm 2 cm2 25 31 6 ET EE 217 N 1 Z ED 3 N 26 1 0 N 20 8 S FU Nn oo lt 1 1 255 13 7 28 9 13 28 9 1 5 Fo EOEI 197 N 3 lt 3 ES ME 8 ls RE Ew 1 2 JG Llz ls an 0 10 1 5 9 3 7 24 43 ET 62 69 177 21 0 35 7 18 9 elsle N 328
123. Catnip oil DEET Journal of medical entomology 42 306 311 2005 Journal of medical entomology 42 643 646 2005 picaridin KBR3023 DEET rd it Rickettsia africae 4 DEET DEET 19 5 Chauhan KR Klun JA Debboun M et al Feeding deterrent effects of catnip oil components compared DEET SS220 with two synthetic amides against Aedes aegypti DEET SS220 James R Roberts William B Wei Michael W Shannon DEET Alternatives Considered to be Effective M
124. oviposition deterrent Journal of Vector Ecology 30 45 48 2005 Klun JA Kramer M Debboun M A new in vitro bioassay system for discovery of novel human use mosquito repellents Journal of the American Mosquito Controi Association 21 64 70 2005 w a Park BS Choi WS Kim JH et ah Monoterpenes from thyme Thymus vulgaris as potentiai mosquito repellents Journai of the American Mosquito Control Association 21 80 83 2005 Frances SP et al Field evaluation of commercial Picaridin DEET repellent formulations against mosquitoes Diptera DEET Cuiicidae in Northern Territory Australia J Am Mosq Control Assoc 2005 21 4 480 2 38 Frances Stephen P Laboratory and field evaluation of commercial repelient formuiations against mosquitoes Diptera Culicidae in Queensland Australia Australian Journal of Entomology 2005 44 431 6 Lee Hoi Seon Food protective effect of acaricidal components isofated from anise seeds against the stored food mite Tyrophagus putrescentiae Schrank J Food Prot 2005 68 6 1208 10 Odalo JO Odalo JO Omolo MO et at Repellency of essentiai o
125. 0 5 gt 3 I 2 2 Qk lt 05 6 4
126. DEEH DEET 30 4 6 ethy1 butyl acety aminopropionate IR3535 DEET Se Ra iR3535 DEET IR3535 DEET V DEET
127. Jourval of Toxicology and Environmental Health 62 BBB BTB 523 541 2001 DEET 14 Abdel Rahman A Shetty AK Abou Donia MB Subchronic dermal application of N N diethyl m toluamide DEET and permethrin to adujt rats alone or in combination causes diffuse neuronal cell death and cytoskeleta abnormalities in the cerebral cortex and the hippocampus and Purkinje neuron loss in the cerebellum Expertimental Neurology 172 153 171 2001 DEET 40mg kg 60 IAbou Donia MB Goldstein LB Jones KH et al DEET 40mg kg 45 Locomotor and sensorimotor performance deficit in rats following exposure to pyridostigmine bromide DEET and permethrin alone and in combination
128. 6 3 3 800 DEET 1 400 1 1 1 400 3 800 12 1 2 7 39 Op ol a a 1 1
129. a DEET m m Cr CD SD 7 m 5 DEET 7 2 mg body day 7 DEET 1 gt m m m m m TK 2 a 1 0 1 2 0 1 0 1 0 1 0 2 a CE RN EE ET 9 m DEET 1 CA1 DEET 0 1 a DEET m m
130. in vitro DEET DEET DEET DEET 87 Gu Xiaochen Transdermal absorption of repellent DEET and sunscreen oxybenzone Acta Pharmacologica Sinica 27 Suppl1 202 2006 Iscan Y Hekimoglu S Sargon MF Hincal AA DEET loaded solid lipid particles for skin delivery in vitro release and skin permeation characteristics in different vehicles 1 J Microencapsul 2006 May 23 3 315 27 Bhatt VD Absorption and evaporation of volatile and potentially hazardous chemicals from human skin J Cosmet Sci 2006 Mar Apr57 2 189 90 Tao Wang In vitro percutaneous permeation of the DEET repellent DEET and the sunscreen oxybenzone across human skin J Pharm Pharm Sci 2007 10 1 17 25 in vitro
131. AChE mAChR Toxicological Sciences 60 305 314 2001 DEET MAP2 Abde Rahman A Dechkovskaia AM Goldstein LB et DEET 40mg kg 30 al Neurological deficits induced by malathion DEET and permethrin alone or in combination in adult rats Jourval of Toxicology and Environmental Health 67 331 356 2004
132. 806 816 2005 Pahwa Punam et al 6 Hodgkin lymphoma multiple myeloma soft tissue sarcomas insect repellents and phenoxyherbicides Joumal of occupational and environmental medicine 2006 48 3 264 74 Bell JW et al Human Exposures to N N diethy m toluamide insect repellents reported to the American Association of Poison Control Centers 1993 1997 International Journal of Toxicoiogy 2002 21 341 52 Adverse Events Associated with the Use of Insect Repellents Containing NN diethy m toluamide DEET REGULATORY TOXICOLOGY AND PHARMACOLOGY 2009 Sep 11 Epub Morton R et al Hypersensitivity pneumonitis in a child associated with EXTOXNET DEET 1997 10 http pmep cce cornell edu orpfiles extonet carary dicrotophos deetexthtml Koren Gideon et al DEET based insect repellents safety implications for children and pregnant and actating women CMAJ 2003 169 3 209 12 Flake ZA Hinojosa JR Brown M et al Clinical inquines Is DEET safe for children The Journal of family practice 54 468 469 2005 NPTN National Pesticide Telecommunications Network 2006 3 31 Tracy M Katz et ai fnsect repellents Historical perspectives and new developments Journal of the American Academy of Dermatology 58 5 865 871 2008 5 2 3
133. lt DEET oxybenzone HPLC DEET DEET Cmax C14 DEET 6 DEET 5 6 15 8 4 Schoenig GP Hartnagel RE Jr Osimitz TG et al EET
134. 4 4 2 18 3 2 2 1 472 40m 10 315 60mi Yi 1ml 35mg 5 5 4 50ml Lo lz a 3 F 3 PS Ce 290ml NZ
135. 6 dn 3 2 4 3 2 4 1 3 2 4 2 i 3 2 43 4 24 4 kk 4 HR ON gt TO 5 1 5 2 2 1 PO070261 DEET 4 4 2 2 P070261 2 3 DEET 28 29 28 DEET 2 4 2 4 1 mg kg mg mL mL kg H 2 0 0 1 DEET 60 60 1 DEET 300 300 1 10 201 205 1 301 305 211 215 311 315 221 225 321 325 231 235 331 335 241 245 341 345 206 210 306 310 216 220 316 320 226 230 326 330 236 240 336 340 246 250 346 35
136. P gp environmental health Part A 2006 69 10 919 33 DEET Roy M J Initial evaluation of N N diethy m toluamide and permethrin absorption in human volunteers under stress conditions Military Medicine 2006 171 2 122 7 DEET Permethrin DEET Permethrin Brand RM Jendrzejewski JL Henery EM Charron AR A single oral dose of ethanol can alter transdermal absorption of topically applied chemicals in rats Toxicol Sci 2006 Aug 92 2 349 55 Epub 2006 May 5 ethanol paraquat dimethylformamide DEET alcohol DEET oxybenzone DEET oxybenzone DEE
137. against Ambyomma americanum Medical and Veterinary Entomology 22 144 151 2008 C Pennetier et al Mixture for controlling insecticide resistant malaria VectorS Emerg Infact Dis 2008 Nov 14 11 1707 14 CODEN PVAEAK 1SSN 1756 3305 Multi function oxidases are responsible for the synergistic interactions occurring between repellents and insecticides in mosquitoes Parasites amp Vectors 2009 2 No pp given David E Wedge et al Bioactivity Guided Fractionation and GC MS Fingerprinting of Angelica sinensis and Angelica archangelica Root Components for Antifungal and Mosquito Deterrent Activity J Agric Food Chem Vol 57 No 2 Page 464 470 2009 01 28 B E Witting Bissinger et al Novel Arthropod Repellent BioUD Is an Efficacious Alternative to Deet J Med Entomol Vol 45 No 5 Page 891 898 2009 09 Grieco John P et al A novel high throughput screening system to evaluate the behavioral response of adult mosquitoes to chemicals Journal of the American Mosquito Control Association 2005 21 4 404 11 Kasichayanula S House JD Wang T Gu X Simultaneous analysis of insect repellent DEET sunscreen oxybenzone and five relevant metabolites by reversed phase HPLC with UV detection application to an in vivo study in a piglet model J Chromatogrraphy 2005 822 271 7 Moody RP et al Dermal absorption of the insect repellent DEET N N diethy m toluamide in rats and monkeys effect of anatomical site and mul
138. components against Tyrophagus putrescentiae a stored food mite Journal of Stored Products Research 2006 42 1 8 14 Naucke Torsten J et al Laboratory testing of the insect repellents 1R3535 and DEET against Phlebotomus mascittii and P duboscqi Diptera Psychodidae International journal of medical microbiology 2006 296 Suppl 1 230 2 Ritchie Scott A et al Field evaluation of New Mountain Sandalwood Mosquito Sticks and New Mountain Sandalwood Botanical Repellent against mosquitoes in North Queensiand Australia Journal of the American Mosquito Contro Association 2006 22 1 158 60 Sfara Valeria et al Toxicity of pyrethroids and repellency of diethyltoluamide in two deltamethrin resistant coloniss of Triatoma infestans Klug 1834 Hemiptera Reduviidae Memorias do Instituto Oswaldo Cruz 2006 101 1 89 94 Tak Jun Hyung Acaricidal activities of paeonol and benzoic acid from Paeonia suffruticosa root bark and monoterpenoids against Tyrophagus putrescentiae Acari Acaridae Pest management science 2006 62 6 551 7 DEET KBR023 DEET KBR023 Tputrescentiae benzy
139. 0 a 70 vol b 28 c 29 2 4 2 8 E mg body day mg mL uL day 0 0 60 DEET 7 2 120 60 d 3 6 5 251 255 5 351 355 5 256 260 5 356 360 P070261 2 4 3 met mm mkg 0oo 3 261 263 DEET 60 60 1 Eo 3 271 273 DEET 300 300 1 3 ES 2 4 4 Sa CmgtbodyGdy mg mL pLday DEET 72 120 3 381 383 1 7 PO070261 3 Crl CD SD DEET 28 29 60 300 mgkg day 28 7 2 mg body day DEET 70 vo
140. 0 4 14 5 10pm 7 re 9 10gm 16 31 20 41 13 9 1 11 7 1 140 20 0 2 0 6 14 5 04 a 5 20 18 2 1 8 5 2 3
141. 22 10 1 1 10ml 3 40 50ml FID GC 2 FID 6C 3 100ml 10 10 FID GC
142. 535 DEET203 Cilek JE Petersen JL Hallmon CE Comparative efficacy of iR3535 and deet as repellents against adut Aedes aegypti and Cuiex quinquefasciatus Journai of the American Mosquito Control Association 20 299 304 2004 permethrin BFU 5096DEET DEET 2 3 BFU 6 5 8 DEET Deparis X Frere B Lamizana M et at Efficacy of permethrin treated uniforms in combination with DEET topical repellent for protection of French military troops in Cote d Ivoire Journal of medical entomology 41 914 921 2004 27 ND Kim SL Chang KS Yang YC et al Repellency of aerosol and cream products containing fennel oil to mosquitoes under jaboratory and field conditions Pest Management Science 60 1125 1130 2004
143. ET HI 2 10 2 5 DEET DEET DEET DEET _ i DEET ethano o w 2 methacryloyloxyethy1 phosphorylcholine buty methacrylate copolymer
144. des albopictus Diptera Culicidae Journal of the American Mosquito Control Association 2006 22 1 126 30 Kiun JA Khrimian A Rowton E Kramer M Debboun M Biting deterrent activity of a deet analog two DEPA analogs and SS220 applied topically to human lyolunteers compared with deet against three species of blood feeding fies J Med Entomol 2006 Nov 43 6 1248 51 Licciardi S Herve JP Darriet F Hougard JM Corbel V Med Vet Entomol 2006 Sep 20 3 288 93 Links Lethal and behavioural effects of three synthetic repellents DEET 1R3535 and KBR 3023 on Aedes aegypti mosquitoes in laboratory assays Chang KS Tak JH Kim Si Lee WJ Ahn YJ Repellency of Cinnamomum cassia bark compounds and cream containing cassia oil to Aedes aegypti Diptera Culicidae under laboratory and indoor conditions Pest Manag Sci 2006 Nov 62 11 1032 8 Gujral IB Zielinski Gutierrez EC LeBailly A Nasci R Behavioral risks for West Nile virus disease northern Colorado 2003 Emerg Infect Dis 2007 Mar13 3 419 25 Canyon DV Speare R A comparison of botanical and synthetic substances commonly used to prevent head lice Pediculus humanus var capitis infestation lnt J Dermatol 2007 Apr46 4 422 6 Wuiff C Haeberlein S Haas W Cream formulations protecting against cercarial dermatitis by Trichobilharzia Parasitol Res 2007 Jun 101 1 91 7 Epub 2007 Jan 25 Moore SJ Davies CR Hill N Cameron MM Are mosquitoes diverted f
145. ils of some plants from the Kenyan coast against Anopheles gambiae Acta Trop 2005 95 210 8 Pennetier C Corbei V Hougard JM Combination of a non pyrethroid insecticide and a repellent a new approach for controlling knockdown resistant mosquitoes Am J Trop Med Hyg 2005 Jun 72 6 739 44 Trongtokit Yuwadee et al Efficacy of repellent products against caged and free flying Anopheles stephensi mosquitoes The Southeast Asian journal of tropical medicine and public health 2005 36 6 1423 31 Tuetun B Choochote W Kanjanapothi D Repellent properties of celery Apium graveolens L compared with commercial repellents against mosquitoes under laboratory and field conditions Trop Med nt Health 11 1190 8 2005 Klun Jerome A et al Repellent and deterrent effects of SS220 Picaridin and Deet suppress human blood feeding by Aedes aegypti Anopheles stephensi and Phlebotomus papatasi Journal of medical entomology 2006 43 1 34 9 Kalyanasundaram Muthuswami et al N N diethyl phenylacetamide DEPA A safe and effective repellent for personal protection against hematophagous arthropods Journal of medical entomology 2006 43 3 518 25 Kim Soon li et al Toxicity of spray and fumigant products containing cassia oil to Dermatophagoides farinae and Dermatophagoides pteronyssinus Acart Pyroglyphidae Pest management science 2006 62 8 768 74 Lee Chi Hoon et_al Acaricidal activity of fennel seed oils and their main
146. l benzoate dibutyi phthalate DEET Anopheles gambiae Ao DEET pyrethroid pyrethroid DEET pyrethroid propoxur hydroxyethyl isobutyl piperidine carboxyiate Rh A graveolens DEET A graveolens 25 DEET25 RS SS220 DEET Picaridin
147. o No No No No 1 4 2 DEET DEET DEET DEET 17 28 17 6 3 6 3 1
148. osquito Repellents American Academy of Pediatrics News June 2005 http www aap org family wnv jun05 htm Jensenius M Pretorius AM Clarke F et al Repellent efficacy of four commercial DEET lotions against Amblyomma hebraeum Acari jxodidae the principal vector of Rickettsia africae in southern Africa Transactions of the Royal Society of Tropical Medicine and Hygiene 99 708 731 2005 in vitro DEET Bayrepel SS220 n vitro DEET DEET Xue RD Ai A Barnard DR Effects of forced egg DEET retention in Aedes albopictus on adult survival and reproduction following application of DEET as an
149. rom repelient using individuals to non users Results of a field study in Bolivia Trop Med int Health 2007 Apr12 4 532 9 Xue RD Ali A Barnard DR Effects of in vivo exposure to DEET on blood feeding behavior and fecundity in Anopheles quadrnmaculatus Diptera Culicidae Exp Parasitol 2007 Ju 116 3 201 4 Epub 2007 Jan 10 Barnard DR Xue RD Rotstein MA Becnel JJ Microsporidiosis Microsporidia Culicosporidae alters blood feeding responses and DEET repeliency in Aedes aegypti Diptera Culicidae J Med Entomol 2007 Nov 44 6 1040 6 DEET 2 DEET
150. t bug repeppent toxic worry BBC NEWS Health Wednesday 5 August 2009 http news bbc co uk 2 hi health 8182052 stm Blanset Diann L Zhang Junfeng Robson Mark G Probabilistic Estimates of Lifetime Daily Doses from Comsumption of Drinking Water containing Trace Levels of N N diethy meta toluamide DEET Tnclosan or Acetaminophen and the Associated Risk to Human Committee on Toxicity of chemicals in Food Conseumer Products and the Enviroment STATEMENT ON THE REVIE OF TOXICOLOGY LITERATUER ON ON THE USE OF TO TOPICAL 1NSECT REPELLENT DIETHYL m TOLUAMIDE DEET DEET COT 02 5 november 2002 Addition to No 4 2paragraph 31 April 2003 http www advisorybodies doh gov uk pdfs deetstate Menon KS Brown AE Exposure of children to Deet and other topically applied insect repellents American Journal of ndustrial Medicine 47 91 97 2005 Seo J Lee YG Kim SD et al Biodegradation of the insecticide N N diethy m toluamide by fungi identification and toxicity of metabolites Archives of Environmental Contamination and Toxicology 48 323 328 2005 Cosmet amp Toiletries magazine 120 59 60 62 64 66 2005 Jortner BS The return of the dark neuron A histological artifact complicating contemporary neurotoxicologic evaluation Neurotoxicology 2006 27 4 628 34 Moser VC Animal models of chronic pesticide neurotoxicity Hum Exp Toxicol 2007 Apr 26 4 321 31 Review
151. tiple exposure J Toxicol Environ Health 1989 26 2 137 47 Taylor WG et al Pharmacokinetic assessrment of the dermal absorption of NN diethy m toluamide DEET in cattle Drug Metab Dispos 1994 228 1 106 12 Selim S Hartnagel RE Jr Osimitz TG Gabriel KL et al Absorptin Metabolism and Excretion of N N Diethy m toluamide Following Dermal Application to Human Volunteers FUNDAMENTAL AND APPLIED TOXICOLOGY 25 95 100 1995 DEET 2 DEET Zo DEET DEET tue a o DEET 3 12
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