TDM ジゴキシン - 積水メディカル株式会社
Contents
1. T 2 1 2 3 1 1 EDTA 22. to 2 1 2 3 4 5 3 1 0 1 1 121C 20 0
3. 1 0 5ng mL 0ng mL 0 03 2 5ng mL 05ng mL 0 15 2 85 115 3 15 1 3 4 7170S 0 2 5ng mL 5 1 N 40 r 0 991 0 98 001 2 N 40 r 0977 1 02x 003 6 1 1 HIV HBV HCV
4. 15 30 C 1 2 8C 6 20 3 9 4 5 12 3 2 1 20mg dL 20mg d 500mg dL 50mg dL 500U L 2 3
5. zg mL 1 000 10 10 100 10 10 100 5 17 g OH 10 100 100 zg mL 10 10 100 10 100 10 100 100 11 OH 10 0 15 50 4 1 ng mL 50 3 6 5 108 0 5 82 0 50 4 4 500 0 7 D 10 000 0
6. 6 DIG DIG 9 9 1
7. 1 Lee KS et al Pharmacol Rev 23 193 1971 2 Lewis RP Am J Cardiol 69 97G 1992 3 Matzuk M M et al Making Digoxin Therapeutic Drug Monitoring More Effective Ther Drug Monit 13 215 219 1991 4 Keys PW et al Practical Applications of Drug Monitoring New York Gross Townsend and Frank Inc vol3 1 21 1981 5 ogestrand T et al Am Heart 117 1076 1989 6 Smith TW et al J Clin Invest 49 2377 1970 7 Rainey PM Am J Clin Pathol 92 779 1990 8 Valdes R Clin 31 1525 1985 9 51 1 131 141 2004 10 0120 249 977 FAX 0120 247 477 13 5
8. 150 0 5 3 1 2 1 DIG DIG DIG 2 37C 37C 10zL 210zL 5 70gL 36 I 37C 4 24 TI T L 700nm
9. 1 0 9 2ng mL 1 2 2 6nmol L 2 5 2ng mL 98 2ng mL 2 3
10. 1 4 2 1 1 2 8C 2 2 TDM DIG 42mLx1 DIG 14mL x 1
11. 201018 002 13A2X00197220004 2012 2 2 2009 3 1 30386000 TDM 1 2 3 4 5
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