Caribou OEMSyringe Pump Component User`s Manual
Contents
1. Immunity IEC 61326 1997 w A1 1998 amp A2 2001 IEC 61000 4 2 1995 IEC 61000 4 3 1996 IEC 61000 4 4 1995 IEC 61000 4 5 1995 IEC 61000 4 6 1996 IEC 61000 4 11 1994 IEC 61000 3 2 2001 w Am 14 IEC 61000 3 3 1995 Corr 1997 Manufacturer s Name Harvard Apparatus Inc Manufacturer s Address 84 October Hill Road Holliston Massachusetts 01746 U S A Type of Equipment Caribou OEM Syringe Pump Model No 98 2482 I the undersigned hereby declare that the equipment specified above conforms to the above Directive s and Standard s EMC and Safety compliance were evaluated by Intertek ETL Semko Reference test report file numbers 310496 and 3103711 Place United States of America Date June 28 2007 C j Signature HARVARD KE APPARATUS VP Engineering Operations Position2. avoid potential hazards and product damage use this product only as instructed in this manual If the equipment is used in a manner not specified by the manufacturer the protection provided by the equipment may be impaired To Prevent Hazard or Injury Use Appropriate Power Supply Use only an approved power supply Be sure to observe proper polarity of connections when hooking up DC supply voltage CAUTION FAILURE TO MAINTAIN POLARITY MAY RESULT IN DAMAGE TO THE UNIT AND WILL VOID THE WARRANTY Vdc positive PIN 5 of 9 Pin D Sub 1 Vdc return PIN 9 of 9 Pin D Sub P1 see input connections diagram Ground the Product This product is grounded through a ground stud located on the under side of the base plate To avoid electric shock the grounding conductor must be connected to earth ground Before making any connections to the input or output terminals of the prod uct ensure that the product is properly grounded Make Proper Connections Make sure all connections are made properly and securely Any signal wire connec tions to the unit must be no longer than 3 meters Orient Equipment Properly Do not position the equipment such that it is difficult to reach the disconnecting device Observe All Terminal Ratings Review the operating manual to learn the ratings on all connections Avoid Exposed Circuitry Do not touch any electronic circuitry inside of the product Do Not Operate with Suspected Failures If damage is suspect
3. includes a mechanism hardware and software and requires the addition of a power supply and user interface Typically the Caribou OEM Syringe Pump Component holds one syringe of any make from 0 5 ul to 60ml The diameter of the syringe is entered via your PC or other con troller and the internal microprocessor drives a precision stepper motor to produce accurate fluid flow This unit is designed to operate inside an appropriately rated fire electrical mechanical enclosure or cabinet Features Two Modes of Operation Constant Flow Rate and Volume Dispense The Caribou OEM Syringe Pump Component will operate continuously in RATE mode or accurately dispense a specific amount of fluid in VOLUME mode When starting the pump RATE mode will be the default mode To operate in Volume mode set a target volume and the pump will change modes to suit desired operation Infuse Limit Switch An infuse limit switch is located on the syringe block and an adjustable actuator is located on the pusher block When the actuator contacts the limit switch infusing is stopped Adjust the actuator appropriately such that the syringe plunger does not bottom out in the syringe Publication 5416 001 REV A Harvard Apparatus Caribou OEM Syringe Pump Component User s Manual Introduction Input Connections Packing List 1 Main Unit 2 Tube of lubricant 3 User s Manual Publication 5416 001 REV A Harvard Apparatus Caribou OEM Syringe Pump Com
4. they apply Do Not Dispose Product with Municipal Waste Special Collection Disposal Required 5 Harvard Apparatus Caribou OEM Syringe Pump Component User s Manual Table of Contents SUBJECT PAGE NO General Information Serial NUMBERS dissec E eee ede eets 2 Calibra 0 ee 2 AEAEE TI i E E E E E E ela E 2 Repa naaran ir e MEDA aE eect ee 2 General Safety Summary ssnsssssnunnennnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn 3 4 Theory of Operation successer een arr 5 Introduction Input Connections u u sssueseeer ener eneret ener kreere nen 6 PACKING Listo aioe E ld terion diene DN RR BERN 6 Installation Location Requirements for the Syringe Pump 0 005 7 Loading the Syringe c cceeeceeeeeeeeeeeeeeeeeeeeeaeeeeeaeeeseeeetias 7 Operation Getting Started ooo ccccecceceeeneeeeeeeeeeeeeeeeeeaeeeseaeeeseeeeeeeeess 8 Hyper Terminal Caribou OEM Syringe Pump Component 006 9 10 Appendix A SPOCCHICATIONS icara eaa kenaii eea paaie 11 RS 232 Power Connector Pin Out s es 12 I O Specifications cececeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeesseeeeeees 12 Appendix B Syringe Inside Diameter seeren 13 Appendix C Flow Rates 2 ccccceceeesseeneeeeeeeeeeeeeeeeenseneens 14 Appendix D Serial Communication Commands Queries and Responses ccceeeeeeeeeees 15 Serial Commands and Their Meanings seeeeeees 15 QulerieS a a eine Mein eins ieee 16 Q
5. Caribou OEM Syringe Pump Component User s Manual MAL 98 2482 HARVARD APPARATUS Publication 5416 001 REV A WEEE RoHS Compliance Statement EU Directives WEEE and RoHS To Our Valued Customers We are committed to being a good corporate citizen As part of that commitment we strive to maintain an environmentally conscious manufacturing operation The European Union EU has enacted two Directives the first on product recycling Waste Electrical and Electronic Equipment WEEE and the second limiting the use of certain substances Restriction on the use of Hazardous Substances RoHS Over time these Directives will be implemented in the national laws of each EU Member State Once the final national regulations have been put into place recycling will be offered for our products which are within the scope of the WEEE Directive Products falling under the scope of the WEEE Directive available for sale after August 13 2005 will be identified with a wheelie bin symbol Two Categories of products covered by the WEEE Directive are currently exempt from the RoHS Directive Category 8 medical devices with the exception of implanted or infected products and Category 9 monitoring and control instruments Most of our products fall into either Category 8 or 9 and are currently exempt from the RoHS Directive We will continue to monitor the application of the RoHS Directive to its products and will comply with any changes as
6. an be between 0 and 1999 Leading zeros and trailing decimal point are optional Any number of digits to the right of the decimal point may be transmitted The number will be rounded Publication 5416 001 REV A 3 Harvard Apparatus Caribou OEM Syringe Pump Component User s Manual Appendix D Serial Communication Queries DIA Returns diameter value units in mm RAT Returns rate value set in current range units VOL Returns current accumulated infused volume units in ml or ul depending on range VER Returns model and version number of firmware TAR Returns target volume units in ml or ul depending on range value format nnnn nnn The returned value is an 8 character string with leading zeros converted to SP characters ACSII 32 decimal The fifth character is a decimal point ASCII 46 decimal Queries with String Response RNG Returns range message character string either ML H ML M UL H UL M LIM Returns limit switch status True False True limit switch actuated EMG Returns emergency stop input status True False True Emergency Stop Error Responses CR LF CR LF prompt Unrecognized command CR LF OOR CRLF prompt Fntered value is out of range Publication 5416 001 REV A Declaration of Conformity In accordance with ISO IEC Guide 22 and EN 45014 Application of Council Directive 73 23 EEC 89 336 EEC Standard s to which conformity is declared Safety EN 61010 1 2 Edition 2001 IEC 61010 2 081 Emissions
7. anty period promptly contact Harvard Apparatus 84 October Hill Road Holliston Massachusetts_01746 1388 using our toll free number 1 800 272 2775 Outside the U S call 508 893 8999 Goods will not be accepted for return unless an RMA returned materials authorization number has been issued by our customer service department The customer is responsible for shipping charges Please allow a reasonable period of time for com pletion of repairs replacement and return If the unit is replaced the replacement unit is covered only for the remainder of the original warranty period dating from the purchase of the original device This warranty gives you specific rights and you may also have other rights which vary from state to state Repair Facilities and Parts Harvard Apparatus stocks replacement and repair parts When ordering please describe parts as completely as possible preferably using our part numbers If prac tical enclose a sample or drawing We offer a complete reconditioning service CAUTION This pump is not registered with the FDAand CAUTION is not for clinical use on human or veterinary FOR RESEARCH USE ONLY patients It is intended for research use only NOT FOR CLINICAL USE ON PATIENTS Publication 5416 001 REV A s Harvard Apparatus Caribou OEM Syringe Pump Component User s Manual General Safety Summary Please read the following safety precautions to ensure proper use of your modular syringe pump To
8. ed on or to the product do not operate the product Contact qual ified service personnel to perform inspection Avoid Pinch Hazards Pinch hazards may exist between the pusher block and the end block and at the belt pulley Avoid placing fingers between these points while the pump is running Procedures which could result in injury shall only be carried out by opera tors who have been warned of the potential hazards and have received ade quate training in carrying out the procedures in the safest possible manner Publication 5416 001 REV A Harvard Apparatus Caribou OEM Syringe Pump Component User s Manual General Safety Summary cont d Place Product in Proper Environment Enviromental Conditions Indoor use only Temperature 5 C to 40 C 40 F to 104 F Humidity 20 to 80 RH Well Ventilated Room Altitude up to 2000 m DC Voltage Fluctuation not to Exceed 5 of Nominal Transient Overvoltage Category II Pump is Rated Pollution Degree I Observe all Warning Labels on Product Read all labels on product to ensure proper usage CAUTION Refer to Manual Caution Pinch Hazard Caution Pinch Hazard Publication 5416 001 REV A s Harvard Apparatus Caribou OEM Syringe Pump Component User s Manual Theory of Operation The new Caribou OEM Syringe Pump Component is designed as a highly precise sin gle syringe infusion pump module capable of moderate to high back pressures The module
9. f when the syringe is empty or is otherwise overloaded Although this presents no hazard to the user or the pump it is prudent to check the syringe from time to time Maintenance Keep the Caribou OEM Syringe Pump Component clean and dry Avoid liquid spills that may find their way into the electronics A small tube of grease is provided for periodic lubrication of the lead screw It is important to keep the leadscrew clean and lubricated To clean the exterior surfaces above the baseplate use a lint free cloth to remove loose dust For more efficient cleaning use a soft cloth dampened with water or an aqueous solution of 75 isopropyl alcohol If the pump does not work properly contact Harvard Apparatus for appropriate instructions Protecting Small Fragile Syringes The Caribou OEM Syringe Pump Component will hold microliter size syringes down to 0 5ul size These small syringes have fine wire plungers that may be damaged if allowed to bottom out The Caribou OEM Syringe Pump Component is equipped with an adjustable limit switch actuator on the pusher block Adjust the limit switch actuator position to prevent damage to small syringes Publication 5416 001 REV A S Harvard Apparatus Caribou OEM Syringe Pump Component User s Manual HYPER TERMINAL Terminal Emulation Software Remote Control via the RS 232 Interface Using HYPERTERMINAL Normally included with most Windows operating systems Caribou OEM Syringe Pump Comp
10. onent 1 Connect the Power RS 232 cable between the Caribou OEM Syringe Pump Component RS 232 IN port and a PC s serial port 2 On the PC running a Microsoft Windows Operating System select START PROGRAMS ACCESSORIES HYPERTERMINAL HYPERTERMINAL to start the Hyperterminal application If Hyperterminal is not available install it from the Microsoft Windows Operating System Install disks or CD ROM 3 Set up the appropriate COMPORT for the following Configure ASCII Setup Baud Rate 9600 Echo typed characters locally Data Bits 8 Line delay 0 Parity None Character delay 0 Stop Bits 2 Wrap lines Flow Cntrl None Emulation Auto Detect Publication 5416 001 REV A Harvard Apparatus Caribou OEM Syringe Pump Component User s Manual HYPER TERMINAL terminal Emulation Software You may want to save the setup information under a descriptive filename 4 At the PC launch hyperterminal with the above setup specifications if it is not already running Type VER at the PC keyboard and verify that the pump module s version is displayed at the PC terminal 5 Type RUN to start the pump type STP to stop the pump After starting the pump gt should be displayed indicating pump is infusing After stopping the pump should be displayed Publication 5416 001 REV A 7 Harvard Apparatus Caribou OEM Syringe Pump Component User s Manual Appendix A Specifications Accuracy Reproducibili
11. pl 1 pl 2 pl 5 pl 10 pl 25 pl 50 pl 100 pl 250 pl 500 pl 1 ml 2 5 ml 3 ml 5 ml 10 ml 20 ml 30 ml 50 ml Diameter pl hr mm 0 103 0 150 0 210 0 330 0 460 0 730 1 030 1 460 2 300 3 260 4 610 7 280 8 660 10 300 14 570 20 050 23 100 26 700 Min 0 001 0 002 0 003 0 006 0 010 0 025 0 049 0 099 0 245 0 491 0 981 2 446 3 461 4 895 9 795 18 548 24 621 32 893 17 715 37 571 73 639 181 845 353 337 889 855 1771 527 1999 999 1999 999 1999 999 1999 999 1999 999 1999 999 1999 999 1999 999 1999 999 1999 999 1999 999 0 001 0 001 0 001 0 001 0 001 0 001 0 001 0 002 0 005 0 009 0 017 0 041 0 058 0 082 0 164 0 310 0 411 0 549 0 295 0 626 1 227 3 030 5 888 14 830 29 525 59 323 147 223 295 772 591 458 1474 976 1999 999 1999 999 1999 999 1999 999 1999 999 1999 999 0 001 0 001 0 001 0 001 0 001 0 001 0 001 0 001 0 001 0 001 0 001 0 003 0 004 0 005 0 010 0 019 0 025 0 033 0 017 0 037 0 073 0 181 0 353 0 889 1 771 3 559 8 833 17 746 35 487 88 498 125 230 177 152 354 480 671 277 891 040 1190 408 ml min 0 000 0 000 0 001 0 001 0 001 0 001 0 001 0 001 0 001 0 001 0 001 0 001 0 001 0 001 0 001 0 001 0 001 0 001 0 000 0 000 0 001 0 003 0 005 0 014 0 029 0 059 0 147 0 295 0 591 1 474 2 087 2 952 5 908 11 187 14 850 19 840 Publica
12. ponent User s Manual Installation Location Requirements for the Syringe Pump A sturdy level clean and dry surface Minimum of one inch 2 5cm clearance around the pump Appropriate environmental conditions Mount into an appropriately rated enclosure or cabinet Loading the Syringe 1 2 3 4 5 6 7 Adjust pusher block bracket 3 and Syringe retainer knobs 5 to capture plunger and body of syringe Release the syringe pusher 2 by pressing the bronze button 1 on the side of the pusher While holding the bronze button in slide the pusher to the left Raise the spring loaded syringe retainer 4 and swing it out of the way Lay the loaded syringe in the V shaped holder 6 Swing the retainer so it holds the syringe in place Move the pusher so it makes contact with the syringe plunger Publication 5416 001 REV A 3 Harvard Apparatus Caribou OEM Syringe Pump Component User s Manual Operation Getting Started Plug one end of the Power RS232 cable into P1 connection on board Connect the other end of the cable into your power supply and PC not included Refer to page 6 of this manual to reference the board connections Working with the Pump The safest way to use the Caribou OEM Syringe Pump Component is in the volume dispense mode The pump will automatically stop when target volume is dispensed Check Syringe Often The Caribou OEM Syringe Pump Component will shut itself of
13. rd is powered on and 5VDC supply is operating RUN LED When illuminated indicates that pump is running When extinguished indicates pump is stopped Publication 5416 001 REV A Harvard Apparatus Caribou OEM Syringe Pump Component User s Manual Appendix B Syringe Inside Diameter Stainless Steel Terumo SGE Scientific Glass Size Diameter Size Diameter Engineering 8 cc 9 525mm 3cc 8 95 mm Size Diameter 20 19 130 5 13 00 25 ul 0 73 mm 50 28 600 10 15 80 50 1 03 20 20 15 100 1 46 Becton Dickinson Plastic 30 23 10 250 2 30 Plasti pak 60 29 10 500 3 26 Size Diameter Sb ee 1 0 ml 4 61 mm erwoo onoject 25 7 28 4 78 mm 3 g Plastic 5 10 30 8 66 12 06 Size Diameter 10 14 57 14 50 4 65 mm 19 13 8 94 Hamilton Microliter 21 70 12 70 Series Gastight 26 70 15 90 Size Diameter 20 40 0 5ul 0 103 mm Air Tite 23 80 cae All Plastic 26 60 0 206 Size Diameter PERETI 0 3257 0 er ONS NC 2 5cc 9 60 mm i een 0 460 s ious Terekia Glass 0 729 20 20 05 0 25 cc 3 45 mm 1 46 30 22 50 0 5 3 45 2 3 50 29 00 4 50 3 26 8 92 4 61 mm Unimetrics 8 99 7 28 Series 4000 amp 5000 11 70 10 3 14 70 14 57 19 58 23 0 0 pl 0 460 mm 22 70 32 6 25 0 729 29 00 50 1 031 100 1 460 250 2 300 500 3 260 000 4 610 Size Diameter Publication 5416 001 REV A Harvard Apparatus Caribou OEM Syringe Pump Component User s Manual Appendix C Flow Rates Nominal Nominal Syringe Size 0 5
14. tion 5416 001 REV A 7 Harvard Apparatus Caribou OEM Syringe Pump Component User s Manual Appendix D Serial Communication Commands Queries and Responses After each transmission to the pump terminating with a CR character ASCII 13 the pump enters remote mode and responds with the character sequence CR LF prompt The prompt characters indicate the status of the pump as follows prompt meaning ASCII code Stopped ASCII 58 decimal gt Running forward ASCII 62 decimal lt Running reverse ASCII 60 decimal Stalled ASCII 42 decimal L Limit switch actuated ASCII 42 decimal ASCII 76 decimal D Disabled by emergency stop ASCII 42 decimal ASCII 68 decimal T Target volume reached ASCII 42 decimal ASCII 84 decimal Serial Commands and Their Meanings Commands RUN Start infuse forward direction STP Stop motor CLV Clears volume accumulator to zero CLT Clears target volume to zero dispense disabled REV Reverses pumping direction Commands with Numbers MMD number Set syringe diameter units are mm Rate is set to zero after MMD command ULM number Set flow rate and range units are microliters per minute MLM number Set flow rate and range units are milliliters per minute ULH number Set flow rate and range units are microliters per hour MLH number Set flow rate and range units are milliliters per hour MLT number Set target infusion volume units are ml or pl depending on range Numbers c
15. tive Low P1 3 External Enable Input Active Low P1 4 Running Output Low RUN High STOP P1 5 24 Volts DC Positive P1 6 RS232 Ground P1 7 RS232 RXD P1 8 RS232 TXD P1 9 24 Volts DC Return The pump is set to the following default parameters on power up and after an external enable command Default Settings Syringe Diameter 2 300 mm Rate 3 000 ul min Range ul min Baud Rate 9600 1 0 Specifications Inputs RUN STOP This is an active low TTL level input pulled up to 5V through a 10K ohm resistor It is ESD protected through a TVS device and filtered with a 0 1uF capacitor to ground Each pulse to a logic low toggles the pump between the RUN and STOP states EXT_ENABL This is an active low TTL level input pulled up to 5V through a 10K ohm resistor It is ESD protected through a TVS device and filtered with a 0 1uF capacitor to ground A transition from logic high to logic low causes the processor to reset to its default state and enables the motor drive A transition from logic low to logic high disables the motor drive through hardware independent of firmware Outputs RUN_IND This is an active low output driven by two 74HCT14 inverters in parallel An on board resistor may be placed in series with this output to provide current limiting The default resistor value is zero ohms A logic low indicates RUN A logic high indicates STOP Indicators Power on LED When illuminated indicates that boa
16. ty Flow Performance Number of Syringes Syringe Sizes Flow Rate Min Max Linear Force Drive Motor Control Drive Ratio Lead Screw Pitch Encoder Step Rate Min Max Pusher Travel Rate Min Max Display Keypad Interface Connectors Power Dimensions Mounting Dims Ground Stud Weight Environmental Operating Temp Humidity Storage Temp Humidity Pollution Degree Compliance Publication 5416 001 REV A 0 35 0 1 lt 6 CV One 0 5 uL min 50 60 mL B D Plastic max 0 001 uL hr with 0 5 uL syringe 0 103 mm dia 10 643 mL min with 50 60 mL syringe 26 7 mm dia 50 Ibs peak 0 9 Stepper Constant Current Drive 0 5A per phase Full 1 2 1 4 1 8 stepping 3 2 1 40 threads per inch Optical 32 line for stall detection 3 8 sec step 840 psec step 0 002 mm min 17 8 mm min None None RS 232 RS 232 Power 9 pin D sub 24VDC 5 12 W max 9 00 in x 5 00 in x 4 15 in L x W x H 22 9 cm x 12 7 cm x 10 5 cm 8 50 in x 4 3125 in Mounting holes for 6 6 screws 21 6 cm x 11 0 cm M5 3 7 Ibs 1 68 kg 5 to 40 C natural convection cooling 20 to 80 RH non condensing 30 to 45 C 10 to 90 RH non condensing Class I Lead Free ROHS Compliant 7 Harvard Apparatus Caribou OEM Syringe Pump Component User s Manual Appendix A cont d RS 232 Power Connector Pin Out P1 1 Ground P1 2 RUN STOP Input Ac
17. ueries with String Response 16 Error Responses ccccesseccceeesseeeeeeeeseeeeeeeeeseeeeeeeenseneaees 16 Publication 5416 001 REV A Harvard Apparatus Caribou OEM Syringe Pump Component User s Manual General Information Serial Number All inquires concerning our product should refer to the serial number of the unit Serial numbers are located on the underside of the mounting plate Calibration All syringe pumps are designed and manufactured to meet their performance spec ifications at all rated voltages and frequencies Warranty Harvard Apparatus warranties this instrument for a period of two years from date of purchase At its option Harvard Apparatus will repair or replace the unit if it is found to be defective as to workmanship or material This warranty does not extend to damage resulting from misuse neglect or abuse normal wear and tear or accident This warranty extends only to the original customer purchaser IN NO EVENT SHALL HARVARD APPARATUS BE LIABLE FOR INCI DENTAL OR CONSEQUENTIAL DAMAGES Some states do not allow exclu sion or limitation of incidental or consequential damages so the above limitation or exclusion may not apply to you THERE ARE NO IMPLIED WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR USE OR OF ANY OTHER NATURE Some states do not allow this limitation on an implied warranty so the above limitation may not apply to you If a defect arises within the two year warr
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