Class II, Type A2 Biological Safety Cabinets
Contents
1. 955 mm 1260 mm 1565 mm 1870 mm 1540 mm 60 6 Exterior height for 110 130 V 60 Hz models of 1 2 mand 1 8m 4 and 6 is 1640 mm 64 6 37 6 49 6 61 6 73 6 1115 mm 1420 mm 1725 mm 2030 mm 43 9 759 9 67 9 7799 1 Exhaust ULPA filter Blower Downtlow ULPA filter angled UV light Retrofit Kit provision for 0 9 1 2 and 1 5 meter 3 4 amp 5 models UV light Retrofit Kit provision for 1 8 meter 6 models 4a 4b IV Bar Retrofit Kit provision Cabinet Size models of 1 2 m and1 8 m 4 and 6 is 715 mm 28 1 Internal height for 110 130V 60Hz 815 mni 2 1 0 9 meter 3 1 2 meter 4 1 5 meter 5 1 8 meter 6 Testing Opening Height 228 6 mm 9 228 6 mm 9 228 6 mm 9 203 2 mm 8 Working Access Height 274 mm 10 8 274 mm 10 8 274 mm 10 8 218 mm 8 6 Electrical outlet Retrofit Kit provision 10 0 9 meter 3 model one single outlet in workzone 1 2 1 5 and 1 8 meter 4 5 amp 6 models two single outlets in workzone N Flectrical Electronics panel Fluorescent lamp Plugged service fixture provisions 2 on each side Stainless steel single piece work tray 14 Safety glass sliding sash window Stainless steel armrest 15 Single piece stainless steel back wall Drain valve Retrofit Kit provision and side walls _ E2. W x D x H Shipping Volume Maximum Additional voltages may be available contact Esco for ordering information Cabinet only excludes optional stand 243 kg 536 lbs 283 kg 624 Ibs 317 kg 698 lbs 350 kg 772 Ibs 292 kg 644 Ibs 345 kg 761 Ibs 410 kg 904 Ibs 486 kg 1072 Ibs 1230 x 940 x 1900 mm 48 4 x 37 x 74 8 1530 x 940 x 1900 mm 602 x3s7 gt x 74 3 1910 x 940 x 1900 mm 75 2 X37 Xx 74 8 2150 x 940 x 1980 mm 84 6 x 37 x 77 9 2 20 m 78 cu ft 2 73 m 97 cu ft 3 41 m 121 cu ft 4 00 m 141 cu ft Comprehensive Performance Testing At Esco Every Labculture LA2 model manufactured by Esco is individually tested documented by serial number and validated with the following test methods Inflow downflow velocity PAO aerosol challenge for filter integrity Light noise and vibration Airflow pattern visualization Electrical safety to IEC61010 1 Additional KI Discus containment and microbiological testing is performed on statistical sampling basis ESO WORLD CLASS WORLDWIDE 10 Microbiological Testing Esco performs testing in accordance with more than 10 of the world s most recognized standards for local regional and international criteria Testing in our microbiology laboratory is conducted according to NSF ANSI 49 EN 12469 and JIS K3800 An NSF accredited biohazard cabinet field certifier is available
3. and North America American style microbial species in the work zone Available for all standard Esco cabinets Europe Worldwide style DIN 12898 e PVC armrest Microscope viewing device DIN 12919 DIN 3537 Chemically treated improves operator Mounting and viewing pouch comfort easy to clean 712 mm integrated into sash Factory installed 28 standard size specify when ordering Labculture Biological Safety Cabinet Class Il Type A2 Biological Safety Cabinets General Specifications International Models Europe Asia Pacific Africa Latin America 230 V 50 amp 60 Hz Nominal Size External Dimensions WxDxH Gross Internal Dimensions WxDxH Usable Work Area LA2 3A1 LA2 3A3 LA2 3J5 0 9 meters 3 1 2 meters 4 1 5 meters 5 1115x810 x 1540 mm 43 9 x 31 9 x 60 6 LA2 4A1 LA2 4A3 LA2 4J5 1420 x 815 x 1540 mm 55 9 x 32 1 x 60 6 LA2 5A1 LA2 5A3 LA2 5J5 1725 x 815 x 1540 mm 67 9 x 32 1 x 60 6 LA2 6A1 LA2 6A3 LA2 6J5 1 8 meters 6 2030 x 815 x 1540 mm 79 9 x 32 1 x 60 6 955 x 623 x 670 mm 37 6 x 24 5 x 26 4 1260 x 623 x 670 mm 49 6 x 24 5 x 26 4 1565 x 623 x 670 mm 61 6 x 24 5 x 260 4 1870 x 623 x 670 mm 73 6 X 24 5 x 26 4 0 45 m 4 8 sq ft 0 6 m 6 5 sq ft 0 75 m 8 1 sq ft 0 9 m 9 7 sq ft Tested Opening 228 6 mm 9
4. e The front grille has proportionally larger perforations on the extreme left and right side Combined with the side air gap between the work tray and the side wall the stronger side capture zones increase protection in this critical area where contaminants tend to bleed out in conventional cabinets e The convex inflow grille maintains operator protection by discouraging users from placing objects on it e Auto purge holes located at the front side walls eliminate eddy currents and dead air pockets in the critical area behind the sash window Per NSF ANSI 49 requirement these side perforations do not extend completely to the work surface to prevent accidental liquid spills in the work zone from entering the side air column e The ULPA downflow supply filter is tilted proportional to the cabinet front angle to direct more air forward to the front air grille e The inflow velocity downflow velocity air flow path and intake geometry are precision tuned and tested to create an optimum air curtain on the front aperture this curtain maintains personnel and product protection even in the unlikely event of a severe inflow or downflow imbalance that would compromise protection in a conventional cabinet Integrated Filtration System A combination of a supply ULPA filter and an exhaust ULPA filter give the Labculture cabinet a fully integrated performance envelope for product operator and environmental protection e ULPA
5. filters per IEST RP CC001 3 are tested to a typical efficiency of gt 99 999 for 0 1 to 0 3 micron particles these provide better filtration capability than conventional HEPA filters that have a typical efficiency of gt 99 99 for 0 3 micron particles Mini pleat Separatorless Filter left vs Conventional Aluminium Separator Filter right Esco cabinets use Swedish Camfil Farr mini pleat filters without aluminum separators to increase filter efficiency minimize the chance of leakage and to prolong filter life Filters include a lightweight aluminum frame for structural stability and elimination of swelling common to conventional wood frames Esco ULPA Filter Efficiency Typical Penetration e Modern separator less mini pleat filter construction maximizes the filter surface area to extend filter life and eliminate possible filter media damage by thin and sharp aluminum separators used in conventional HEPA filter construction e The filter frame and media is constructed in accordance with EN1822 requirements for fire retardant properties e The supply ULPA filter provides ISO Class 3 per ISO14644 1 clean air to the work surface in a gentle vertical laminar flow for product protection e The exhaust ULPA filter traps biohazard particles acquired from the work surface before air is exhausted to the room offering personnel and environmental protection e The exhaust filter media is protected from me
6. sash cable and cable clip have rated strength of more than 6 times the weight of the sash window of the largest Labculture Class Il cabinet 1 8 meter 6 ft model e The safety glass maintains containment if the sash is accidentally broken during cabinet operation Blower Efficiency The Labculture blower system is designed for high performance operation maximum energy efficiency and minimal maintenance e The external rotor motor design allows for optimum cooling of the motor during extended operations and extends the motor bearing life Cabinet Filtration System Side capture zones Dynamic air barrier inflow and forward directed downflow air converge Ambient air is pulled through the perforations located towards the work zone front to prevent contamination of the work surface and work product The inflow does not mix with the clean air within the cabinet work zone Inflow air travels through a return path toward the common air plenum blower plenum at the top of the cabinet Approximately 37 of the air in the common plenum is exhausted through the ULPA filter to the room The remaining 63 of the air is passed through the downflow ULPA filter and into the work area as a vertical laminar flow air stream bathing the work surface in clean air The uniform non turbulent air stream protects against cross contamination O aie tNrougr out tn W OIS a 4 e The blower motor can maintain airflow for a 150 i
7. serial number shall be provided with the cabinet and maintained in the manufacturers records Test data verifying all performance criteria shall be available upon request to include a inflow velocity through direct inflow measurement method b downflow velocity and uniformity c filter leak scan with aerosol challenge for both filters d light noise vibration e and electrical safety Filtration System 6 The cabinet shall have one supply downflow filter and one exhaust filter Both filters shall be ULPA type per IEST RP CC001 3 and meet EN1822 H14 requirements 7 The filters shall be within an aluminum frame with mini pleat design without aluminum separators no wood or fiberboard shall be used in the filter assembly 8 Typical filter efficiency shall be 99 9997 at MPPS and 99 999 for 0 1 to 0 3 microns 9 An integral filter guard shall be affixed to prevent damage to the filter media 10 The filters shall be a individually scan tested by the manufacturer b individually scan tested after assembly and b easily accessible for scan testing in situ by means of a dedicated upstream sampling port accessible from within the cabinet 11 The supply filter shall be angled and oriented to the 10 cabinet front angle to maximize downflow uniformity over the work surface 12 A removable perforated metal diffuser shall be installed below the supply filter to optimize airflow uniformity and to protect
8. the agar plates shall not exceed 10 CFU per test Product Protection Test The test objective is to determine cabinet protection to the product samples inside the cabinet workzone from environmental contaminants e A nebulizer containing 55 mL of 5 to 8 x 10 spores mL B atrophaeus is placed at 10 cm 4 inches in front of sash window e Target agar plates are placed throughout the entire work surface e Acceptance The number of Bacillus atrophaeus CFU recovered from the agar plates shall not exceed 5 CFU per test Cross Contamination Test The test objective is to evaluate cabinet protection from cross contamination of samples placed simultaneously inside the workzone e A nebulizer containing 55 mL of spores 5 to 8 x 10 mL is placed against one of the workzone sidewalls e Target agar plates are placed 36 cm 14 away from the same side wall e Acceptance The number of Bacillus atrophaeus CFU recovered on agar plates shall not exceed 2 CFU per test Esco cabinets are designed to operate within a performance envelope to maintain protection for personnel product and the environment Airflow parameters used to frame the performance envelope include both inflow velocity and downflow velocity The graph illustrates the boundaries of the performance envelope based on a 1 2 meter 4 ft cabinet as well as the nominal performance point at which tests are conducted The range between high and low In
9. x37 x 77 9 Shipping Volume Maximum 2 20 m 78 cu ft 2 73 m 97 cu ft 3 41 m 121 cu ft 4 00 m 141 cu ft Additional voltages may be available contact Esco for ordering information Cabinet only excludes optional stand Accessories and Options Cont Cabinet Accessories e Ergonomic lab chair e Cradle stand electrical hydraulic e Germicidal UV lamp Laboratory grade construction infinitely adjustable with casters Controlled by automatic UV lamp meets Class 100 cleanliness alcohol Elevates to seating or standing timer through Sentinel micro resistant PVC materials work surface height processor control panel Adjustable 395 490 mm 15 6 19 3 When lowered permits movement 7 Emission of 253 7 NANOMELels for e Ergonomic foot rest through standard doorway most efficient decontamination Angled helps maintain proper Note Increases exterior dimensions Lamp is positioned away from posture operator line of sight for safety and Adjustable height proper exposure to interior surfaces Anti skid coating chemical Note UV lamp intensity reduces over resistant finish time and its effectiveness is subject to e Electrical outlet Europe Worldwide factors such as relative humidity in the e IV bar with hooks Stainless steel construction Electrical Outlets and Utility Fixtures e Electrical outlet ground fault North America e Petcock air gas vacuum cabinet ambient air temperature
10. 228 6 mm 9 228 6 mm 9 203 2 mm 8 Working Opening 274 mm 10 8 274 mm 10 8 274 mm 10 8 248 mm 9 8 Average Airflow Inflow 0 53 m s 105 fom Velocity Downflow 0 35 m s 70 fpm 0 35 m s 70 fpm 0 35 m s 70 fpm 0 33 m s 65 fpm Inflow 419 m h 246 cfm 552 m h 325 cfm 685 m h 403 cfm 724 m h 426 cfm Downflow 63 702 m3 h 413 cfm 924 m h 544 cfm 1147 m3 h 675 cfm 1289 m h 758 cfm Exhaust 37 419 m h 246 cfm 552 m h 325 cfm 685 m h 403 cfm 724 m h 426 cfm Airflow Volume Required Exhaust one 707 m3 h 416 cfm 901 m3 h 530 cfm 1114 m3 h 656 cfm 1256 m3 h 739 cfm Thimble Exhaust Collar ULPA Filter Typical Efficiency gt 99 999 at particle size between 0 1 to 0 3 microns NSF ANSI 49 lt 66 dBA lt 63 5 dBA lt 66 dBA lt 67 dBA Sound Emission EN 12469 lt 63 dBA lt 60 5 dBA lt 63 dBA lt 64 dBA gt 1230 Lux gt 1400 Lux gt 1070 Lux gt 1225 Lux Fluorescent Lamp Intensity Cabinet Construction 220 240V AC gt 114 foot candles gt 130 foot candles gt 100 foot candles gt 114 foot candles Electrogalvanized steel with Isocide oven baked epoxy polyester powder coating 1 2 mm 0 05 18 gauge 50Hz 10 LA2 3A1 LA2 4A1 LA2 5A1 LA2 6A1 Electrical ual a LA2 3A3 LA2 4A3 LA2 5A3 LA2 6A3 60Hz 19 ee LA2 3J5 LA2 4J5 LA2 5J5 LA2 6J5 50 60Hz 10 Net Weight Shipping Weight Shipping Dimensions Maximum
11. Cabinets Warranty The Labculture cabinet is warranted for 3 years excluding consumable parts and accessories e Each cabinet is shipped with a compre hensive user s manual complete with a report documenting all test procedures e Additional IQ OQ documentation is available upon request e Contact your local Sales Representative for specific warranty details or docu mentation requests Accessories and Options Esco offers a variety of options and accessories to meet local applications Contact Esco or your local Sales Represen tative for ordering information Support Stands e Fixed height available 711 mm 28 or 864 mm 34 38 1 mm 1 5 With leveling feet With casters e Adjustable height hydraulic range 711 mm to 864 mm 28 to 34 With leveling feet With casters e Telescoping height stand for leveling feet nominal range 660 mm or 960 mm 26 or 37 8 e Telescoping height stand for casters nominal range 660 mm or 880 mm 26 or 34 6 Adjustable in 25 4 mm 1 increments All exterior painted surfaces are powder coated with Esco Isocide an antimicrobial inhibitor to minimize contamination Isocide is integrated into the coating substrate and cannot wash out or diminish by repeated cleaning Performance results are available upon request Contact Esco or your Esco Sales Representative for details Model LA2 Biological Safety Cabinet Technical Specifications
12. Labculture ISF 49 UL 61010 JIS K3800 SFDA YY 0569 EN 12469 SA Labculture Class Il Type A2 Biosafety Cabinet Model LA2 4A_ Class Il Type A2 Biological Safety Cabinets The Safety Solution for Life Science Laboratories ECEO WORLD CLASS WORLDWIDE i J P O Dp 0 A Main Features Unique Esco Dynamic Chamber plenum Negative pressure plenum surrounds contaminated positive pressure plenum no fabric bags are used Dual long life ULPA filters for supply and exhaust per IEST RP CC001 3 with 99 999 efficiency for particle size between 0 1 to 0 3 microns Angled supply filter matches cabinet profile to achieve best downflow uniformity j Esco Sentinel microprocessor e _ _ Frameless shatterproof sash is easier to clean Ergonomically angled front improves reach and comfort Actual work access height is 45 mm 1 8 higher than tested sash opening 2 i l oo pelien z z Cc lt a aaa aa aa aa Removable one piece work surface simplifies cleaning A Raised airflow grille maintains safety by preventing blockage pm Optional UV lamp is located behind control panel away from line of sight Does not apply to 1 8 m 6 models ee Esco ISS amp lt iGE antimicrobial coating on all painted surfaces minimizes contamination Enhanced side capture zones optimize containment Work area on Esco 0 9 meter 3 cabinet is equivale
13. actory tested on sampling basic using the KI Discus method for operator safety Purchase Specifications LA2 Series Class Il Type A2 Biological Safety Cabinet General Performance and Certifications 1 The biological safety cabinet shall comply with one or more of the following international standards and the manufacturer shall provide a certified copy of containment and performance tests equivalent to or greater than specified in the following independent international standards for biological safety electrical and other functional characteristics Class Il Type A2 per NSF ANSI 49 USA Class Il per EN 12469 JIS K3800 SFDA YY 0569 SANS12469 2 The cabinet shall protect a the operator and laboratory environment from particulates generated within the work zone b the product and process within the work zone from airborne contamination from ambient air c and the product and process within the work zone from cross contamination 3 Before shipment each cabinet shall be individually tested by the KI Discus test European Standard EN12469 2000 to validate operator personnel protection The retention efficiency for the front aperture shall be not less than 99 999 Microbiological testing for cabinet performance shall be performed on a statistical sampling basis 4 Each cabinet shall be listed by Underwriters Laboratories UL CUL or CE for electrical safety 5 Original documentation specific to each cabinet
14. ahrain escoglobal com SB creodchatcom 2007 Esco Micro Pte Ltd Specifications Subject to Change OW8480F 06 08 Esco Micro Pte Ltd PT Esco Bintan Indonesia Cert No 651333 Cert No 651333 1
15. arm can be activated or deactivated depending on user preference and nature of the work Consult your Esco Operating Manual or contact your Sales Representative for information on user preference programming capabilities built into the Sentinel microprocessor platform Cabinet Construction Robust construction and enhanced safety features qualify the cabinet for the most demanding laboratory applications The cabinet is fully assembled and ready to install The interior work area is formed from a single piece of stainless steel with large radius corners to simplity cleaning The cabinet work zone has no welded joints to collect contaminants or rust All stainless steel work surfaces are accessible for cleaning Tray components lift and remove to provide easy access and encourage surface decontamination A recessed central area and stainless steel drain pan channels spills and prevent liquids from entering the lower walls to eliminate concealed or hard to clean spaces e There are no screws in on the front or sides to trap contaminants or complicate cleaning e Optional service fittings are offset for easier access Fy e External plumbing is concealed behind trim panels to maintain aesthetics e External surfaces are coated with Esco lsocide antimicrobial coating to protect against surface contamination and inhibit bacterial growth Isocide eliminates 99 9 of surface bacteria and operate when shippe
16. cacy is dependent on such variables e HPV has a better penetration capacity resulting in a full decontamination of the cabinet The formaldehyde method is known to result in incomplete decontamination e HPV is more effective and rapid against biological organisms compared to formaldehyde e HPV requires approximately 4 7 hours for set up decontamination and tear down compared to a total of 12 15 hours needed to complete a formaldehyde decontamination process e HPV decontamination effectiveness is independent of temperature and humidity Formaldehyde requires temperature above 20 C and relative humidity above 65 e For information on the BIOQUELL HPV methodology contact Esco or your Sales Representative KI Discus Containment Test According to EN 12469 Potassium lodide Esco is currently one of the few companies in the world equipped to perform the KI Discus test for our customers The KI Discus test is defined in the European Standard for microbiological safety cabinets EN 12469 as a test method for validating the operator personnel protection capabilities of the cabinet e The KI Discus test shows excellent correlation with the microbiological test method for operator protection and is useful for validating the actual containment performance of the cabinet on site e The Kl Discus takes only 45 minutes as opposed to 2 days for microbiological testing e Thus each Esco Labculture LA2 models are f
17. chanical damage by an integrated metal screen guard which is absent from conventional HEPA filters e The top cabinet surface is slanted to discourage users from placing objects which could block the exhaust filter and reduce inflow velocity Front Sash Assembly e Integrated sash proximity contacts sense proper sash position serve as an interlock for the UV lamp and activate an alarm if the sash is improperly positioned e The magnetic switch eliminates the chance of wear and tear typical of a mechanical switch e The back of the sash can be easily cleaned by removing the sash track cover and swinging up the sash glass e Thesash is counterbalanced for smooth lightweight operation Esco cabinets use ULPA filters per IEST RP CC001 3 instead of conventional HEPA filters commonly found in biological safety cabinets While HEPA filters offer 99 99 typical efficiency at 0 3 micron level ULPA filters 0 0002 5 se 0 0 05 0 10 0 15 0 20 0 25 0 30 Particle Size um Typical Penetration provide 99 999 typical efficiency for particle sizes of 0 1 to 0 3 0 40 0 50 micron level ESEO WORLD CLASS WORLDWIDE ULPA filtered air L Unfiltered potentially contaminated air L Room air Inflow air e The counterbalance locking mechanism is inherently safe it locks the counter balance in place if either of the 2 cables is detached The
18. d filtration and blower systems e The drain pan is flush with the side within 24 hours of exposure Robust Cabinet Construction and Enhanced Safety Features Service fixtures are offset for easier reach Standard cabinets include two fixture provisions on each sidewall one provision on each sidewall for 0 9 meter 3 ft cabinet Electrical outlets are mounted below service fixtures to minimize obstructions Helpful for certifiers the hinged maintenance assembly opens to a fixed position on integrated gas spring struts providing front service access All key components with the exception of the blower motor assembly are mounted outside the air stream and away from contaminated air to permit service without decontamination These include fluorescent lamps UV lamp electrical harnesses electronic boards and microprocessor control Panels enclosing potentially hazardous areas or components such as microbiological contamination or electrical shock are color coded red to warn service technician The telescoping Dynamic Chamber plenum minimizes physical lifting and accelerates filter change when required Work area containment is maintained even when removable components are lifted out for cleaning The one piece stainless steel work tray edges are radiused and easy to clean without crevices or joints The lower drain trough is a single piece fabrication with wide open angles and a channel to direct spills to the drain The closed si
19. dewall contains no perforations air return slots or other hidden areas where contaminants can accumulate WORLD CLASS WORLDWIDE Biosafety Cabinets Air Quality Filtration Electrical Safety NSF ANSI 49 USA EN 12469 Europe JIS K 3800 Japan SFDA YY 0569 China ISO 14644 1 Class 3 Worldwide JIS B9920 Class 3 Japan JIS BS5295 Class 3 Japan US Fed Std 209E Class 1 USA EN 1822 H14 Europe lIEST RP CC001 3 USA IEST RP CC007 USA IEST RP CC034 1 USA UL C 61010A 1 USA CSA22 2 No 1010 192 Canada EN 61010 1 Europe IEC61010 1 Worldwide Standards Compliance Please refer to the specifications table on page 8 for the model listing Dynamic Chamber Plenum Design I Negative pressure J Positive pressure The Esco triple wall design creates a Dynamic Chamber plenum which surrounds contaminated areas with negative pressure preventing the possibility of contamination from leaks in filter seal gasket or cabinet structure The third wall conceals utilities Comfortable Ergonomic Design The LA2 cabinet is engineered for comfort utility value and safety e The 10 angled viewing window and narrow profile front grille improves reach into the work area e The instant start 5000k fluorescent lamp operates on an electronic ballast to reduce heat improve comfort and conserve energy e The lamp delivers uniform lighting to the work surface for greater comfort reduced glare and improv
20. ed productivity see Technical Specifications ISOCID e The front armrest is raised above the workzone to improve comfort and to ensure that the operator s arms do not block the forward airflow perforations e The optional adjustable support stand provides work surface height control e The frameless sash eliminates operator s line of sight blockage e A generous sash opening allows for easier access into the work zone provides ample room for transferring of small equipment e The sliding window can be fully opened to insert and remove larger instrumentation and equipment Electrical Safety and Certification All components meet or exceed applicable safety requirements e Each cabinet is individually tested for electrical safety at factory e Documentation specific to each cabinet serial number is maintained on file e UL Listed for USA and Canada e Certified to all major world standards for biological safety cabinets including the NSF ANSI 49 and EN 12469 refer to Standards Compliance table on this page for the full list e Contact Esco or your Sales Representative for site preparation information see Electrical Specifications 3G lt civE Antimicrobial Powder Coating Bacterial Population 10 folds 8 hours 0 4 hours 12 hours 16 hours 20 hours 24 hours Contact Time in Hours Labculture Biological Safety Cabinet Class Il Type A2 Biological Safety
21. ence will prepare the cabinet for normal operation and advise when safe conditions are established An administrator controlled PIN Personal Identification Number can be set to restrict access to main menu Touchpad data entry buttons permit control settings and access to diagnostics default settings and hierarchical menus Programmable automatic UV light timer simplifies operation enhances contamination control extends UV lamp life and saves energy A graphical interface indicates cabinet performance Digital read out with alpha numeric display indicates all input status and alarm functions Color coded indicator lamps display green for primary function fan operation blue for secondary function fluorescent lights and electrical outlet and orange for caution UV lamp ON All functions can be user activated through touch pad programming access see Operations Manual Read all safety related instructions beatore use Test cortify this cabinet at least annually ESCO Designed io Mant IEC 61011 ArGe i RProecion Standard 30O 9001 T Qu lily Certified nul ct nng Enwronneni Sentinel Microprocessor Control System Programmable When programmed ON e the start up sequence confirms status with Air Safe and local time display e the Personal Identification Number PIN access restricts unauthorized adjustments e an airflow alarm warns of deviations from normal velocities e The airflow al
22. flow and high and low downflow together with the fluid dynamics achieved through sophisticated cabinet design proportionally size capture slots and uniform laminar airflow combine to deliver a complete containment and safety solution expected of a professional biological safety cabinet For details on the Esco performance envelope contact Esco or your Esco Sales Representative 0 50 m s Biological Safety Cabinet Class Il Type A2 Biological Safety Cabinets HPV Test Compliant Safer Hydrogen Peroxide Decontamination Compatibility Esco biological safety cabinets are Hydrogen Peroxide Vapor HPV compliant and decontaminatable cabinets approved by BIOQUELL for this patented process HPV is asafer and more efficient alternative to conventional decontamination using formaldehyde CH20 e HPV is non carcinogenic and odorless while formaldehyde is carcinogenic toxic and has pungent smell e lf there is a gap on the cabinet sealing escaping HPV to the lab will decompose to become oxygen and water Escaping formaldehyde however is harmful to people in the lab Therefore HPV decontamination can be performed while people still working inside the lab while formaldehyde decontamination must be performed with no one present in the lab The HPV method improves safety productivity and reduces the time to seal the cabinet e HPV biological efficacy is independent of environmental variables whereas formaldehyde effi
23. from damage Blower System 13 The cabinet shall have a direct drive permanently lubricated centrifugal blower motor dynamically balanced in two planes compliant to ISO2710 for low noise low vibration and long filter life 14 The blower motor shall have an external rotor design and include an automatic thermal cut out to disable the motor in case of overheating 15 The blower motor shall have an automatic speed control to compensate for filter loading 16 The blower motor system shall be enclosed within a dynamic chamber shaped steel plenum and integrated with the removable supply filter assembly to simplify filter changing 17 The integral damper shall be externally adjustable Cabinet Design Construction Cleaning 18 The cabinet shall be of triple wall design whereby all positive pressure plenums capable of handling contaminated air shall be surrounded by negative pressure No positive pressure areas shall be accessible external to the cabinet The third wall shall conceal utilities 19 The cabinet shall maintain containment performance even when removable work area components are removed for cleaning 20 The work tray shall be one piece removable Stainless steel with radius corners without crevices or joints 21 The cabinet shall have a stainless steel one piece fabricated drain trough with open angles to channel spills to a common drain 22 The closed sidewall shall be sealed without perforations re
24. in house full time to supervise all testing work Harmless Bacillus atrophaeus formerly Bacillus Subtilis bacteria is used to challenge the cabinet then incubated for 48 hours and the Colony Forming Units CFU are counted to determine the testing results Increased microbiological challenge tests with objects inside the cabinet work zone Bunsen burner external airflow disturbance and Human As Mannequin test adapted from Fume Hood development were performed to simulate real world conditions Personnel Protection Test The test objective is to evaluate the safety of the cabinet for the personnel operating on potentially hazardous samples in the cabinet workzone e A nebulizer containing 55 mL of 5 to 8 x 108 spores mL B atrophaeus spores is placed inside the workzone 10 cm 4 inches behind the front opening sash e Target slit air samplers and impingers are placed outside the workzone to capture The Performance Envelope Concept 0 65 m s High Inflow 0 60 High Downflow 0 61 0 43 High Inflow Low Downflow 0 58 0 27 0 55 Wominal 0 53 0 35 0 50 Inflow Velocity 0 45 0 35 Low Inflow Low Downflow 0 325 0 25 0 20 0 25 0 30 Downflow Velocity Labculture Low Inflow High Downflow 0 32 0 45 0 35 0 40 0 45 possibly escaping B atrophaeus spores then the sample Is incubated e Acceptance The number of Bacillus atrophaeus CFU recovered from
25. itions such as improper airflow or sash position 42 Airflow shall be monitored by a temperature compensating thermistor based true air velocity sensor mounted in the cabinet 43 The airflow display and alarm system shall be individually calibrated before shipment 44 The main control panel shall exhibit continuous display of air velocity and a 24 hour clock display Certification Service and Decontamination 45 The cabinet shall be approved for both hydrogen peroxide vapor HPV and formaldehyde decontamination protocol 46 All panels leading to potentially contaminated and or hazardous areas shall be color coded red 47 All components with the exception of blower motor and ULPA filters shall be located outside of contaminated air spaces to facilitate servicing without the need to decontaminate the cabinet 48 All exterior surfaces shall be painted with a permanent antimicrobial inhibitor coating to minimize contamination ESO WORLD CLASS WORLDWIDE 11 Esco Containment Clean Air and Laboratory Equipment Products Biological Safety Cabinets Class Il IH Fume Hoods Conventional High Performance Ductless Carbon Filtered Laminar Flow Cabinets Horizontal Vertical PCR Animal Containment Workstations Hospital Pharmacy Isolators Cytotoxic Safety Cabinets Specialty Workstations n Vitro Fertilization Powder Weighing PCR Thermal Cyclers Conventional Real Time Cleanroom Fan Filter Units Modu
26. lar Rooms Air Showers Pass Thrus Since 1978 Esco has emerged as a leader in the development of controlled environment laboratory and cleanroom equipment solutions Products sold in more than 100 countries include biological safety cabinets fume hoods ductless fume hoods laminar flow clean benches animal containment workstations cytotoxic cabinets hospital pharmacy isolators and PCR cabinets and instrumentation With the most extensive product line in the industry Esco has passed more tests in more languages for more certifications throughout more countries than any biosafety cabinet manufacturer in the world Esco remains dedicated to delivering innovative solutions for the clinical life science research and industrial laboratory community www escoglobal com NSF ANSI 49 Biological Safety Cabinets e Animal Containment Workstations e Fume Hoods Clean Benches ESCO WORLD CLASS WORLDWIDE Esco Technologies Inc e 2940 Turnpike Drive Units 15 16 e Hatboro PA 19040 USA Toll Free USA and Canada 888 375 ESCO e Tel 215 441 9661 Fax 215 441 9660 us escoglobal com usa escoglobal com Esco Micro Pte Ltd e 21 Changi South Street 1 Singapore 486 777 Tel 65 6542 0833 Fax 65 6542 6920 mail escoglobal com www escoglobal com Esco Global Offices Singapore Philadelphia USA Leiden The Netherlands Salisbury UK Kuala Lumpur Malaysia Beijing Shanghai amp Guangzhou China Mumbai India Manama B
27. m h 403 cfm 724 m h 426 cfm Downflow 63 702 m3 h 413 cfm 924 m h 544 cfm 1147 m h 675 cfm 1289 m3 h 758 cfm Exhaust 37 419 m h 246 cfm 552 m h 325 cfm 685 m h 403 cfm 724 m h 426 cfm Airflow Volume Required Exhaust Wit Optional 707 m h 416 cfm 901 m h 530 cfm 1114 m h 656 cfm 1256 m h 739 cfm Thimble Exhaust Collar ULPA Filter Typical Efficiency gt 99 999 for particle size between 0 1 to 0 3 microns per IEST RP CC001 3 NSF ANSI 49 lt 66 dBA lt 64 5 dBA lt 66 dBA lt 67 dBA Sound Emission EN 12469 lt 63 dBA lt 61 5 dBA lt 63 dBA lt 64 dBA E E E gt 1230 Lux gt 1400 Lux gt 1070 Lux gt 1225 Lux p y gt 114 foot candles gt 130 foot candles gt 100 foot candles gt 114 foot candles NSF ANSI 49 Certified Pending Yes Yes Yes Electrogalvanized steel with Isocide oven baked epoxy polyester powder coating 1 2 mm 0 05 18 gauge 1 5 mm 0 06 16 gauge 1 2 mm 0 05 18 gauge 1 5mm 0 06 16 gauge Cabinet Construction Electrical 110 130V AC 60Hz 1 Net Weight 243 kg 536 Ibs 336 kg 741 Ibs 317 kg 698 Ibs 434 kg 957 lbs Shipping Weight 292 kg 644 lbs 400 kg 880 Ibs 410 kg 904 Ibs 523 kg 1153 Ibs Shipping Dimensions 1230 x 940 x 1900 mm 1530 x 940 x 1900 mm 1910 x 940 x 1900 mm 2150 x 940 x 1980 mm Maximum W x D x H 48 4 x 37 x 74 8 60 2 x37 x 74 8 TOA XIV XAB 84 6
28. ncrease in pressure loss over clean filters without manual speed control adjustment or 210 increase in pressure drop across the filter with manual speed control adjustment Applies to 1 2 meter 4 ft model contact Esco for information on other models e The permanently lubricated direct drive external rotor motor blower reduces operating costs e Built in RFI and electrical noise filters eliminate interference with adjacent instrumentation e An integral blower hour meter tracks operating life for predictive maintenance planning e To prevent fan damage a paper catch grille traps papers or towels that may drop down on the drain pan preventing them from being pulled into the column by fan suction Esco Centrifugal Fan with External Rotor Motor left vs Conventional Fan with Standard Motor right Labculture sco cabinets use German made ebm papst permanently lubricated centrifugal motor blowers with external rotor designs ntegrated blades narrow the profile and eliminate need for a motor shaft Motors are selected for energy efficiency compact design and flat profile The completely integrated assembly optimizes motor cooling All rotating parts are unitized and balanced for smooth quiet vibration free operation Biological Safety Cabinet Class Il Type A2 Biological Safety Cabinets Near the work surface the downflow air stream splits with a portion moving toward the front air g
29. nt to work area offered on larger 1 2 meter 4 conventional cabinet Each cabinet is Kl Discus tested for performance integrity Available in 0 9 1 2 1 5 and 1 8 meter models 3 4 5 and 6 NSF G ni FD EN H k Gy Shown with optional telescoping stand uy S A NSF 49 UL 61010 JIS K3800 SFDA YY 0569 EN 12469 SANS 12469 Esco Labculture has passed more performance tests in more languages for more certifications throughout more countries than any other biological safety cabinet in the world Labculture Biological Safety Cabinet Class Il Type A2 Biological Safety Cabinets rece Labculcure Operator Product and Environmental Protection The Esco Labculture Class Il Type A2 Biological Safety Cabinet provides operator product and environmental protection against Biosafety Levels 1 2 and 3 This cabinet can be used for handling Biosafety Level 4 provided that the operator wears positive pressure suit Containment and Protection The airflow ratio of 63 recirculation to 37 exhaust increases operator protection beyond the 70 30 ratio of conventional biological safety cabinets e The inflow and downflow balance is precisely established by an external exhaust damper and is adjustable without decontaminating the cabinet e Inflow of room air enters the front air grille to establish operator protection room air does not enter the work zone preventing product contamination
30. r comfort reduce glare and maximize reach into the work area 32 The front grille shall be raised to prevent airflow blockage and improve comfort 33 Penetrations for petcocks and service fittings Shall be provided penetrations shall be offset to improve user access 34 The cabinet shall accommodate an optional mounting stand for fixed height or adjustable height configurations Control and Alarm System 35 All cabinet functions shall be managed by a programmable microprocessor control system capable of software updates via Internet downloads 36 The microprocessor controller shall be mounted on the main control panel facing down toward the user 37 The controller shall include soft touch keypad controls and backlit LCD displays to permit operation of the blower motor light UV lamp electrical outlet s and menu 38 The controller shall be user programmable in situ to enable or disable functions such as PIN personal identification number access restriction cabinet start up protocol airflow alarm and other microprocessor controlled operations outlined in the user manual 39 When programmed ON the start up protocol Shall perform an automatic pre purge and post purge cycle to ensure proper cabinet operation 40 The controller shall include a blower motor hours meter to display aggregate motor running time to assist in predictive maintenance 41 Audible and visual alarms shall be provided for unsafe cond
31. rille and the remainder moving to the rear air grille A small portion of the ULPA filtered downflow enters the intake perforations at the side capture zones at a higher velocity small blue arrows A combination of inflow and downflow air streams forms an air barrier that prevents contaminated room air from entering the work zone and prevents work surface emissions from escaping the work zone Air returns to the common air plenum where the 37 exhaust and 63 recirculation process is continued Sentinel Microprocessor Control Alarm Monitoring System The Esco Sentinel microprocessor based control system supervises operation of all cabinet functions e The control panel is located on the center of the cabinet and angled down for easy access by the operator e Continuous monitoring of cabinet airflow is displayed on a bright easy to read LCD panel e An integrated temperature compen sated true airflow velocity sensor provides an accurate airflow reading despite room temperature fluctuation e All electronic parts are contained inside a plug and play module that permits easy exchange if required e Microprocessor software updates are available from Esco for download via the Internet Sentinel functions are factory set to default to ON or OFF depending on worldwide destination and local preferences Default settings can be user activated through the touchpad data entry access e Automatic start up sequ
32. sco Sentinel microprocessor contro 16 Removable side panel for plumbing system access Optional Exhaust Collar Positions for Thimble Ducting for LA2 Models 129 mm 5 17 Side View All Sizes 333 mm 1321 269 mm 10 6 Top View LA2 4A_ Top View LA2 5A_ 691 mm 27 2 Top View LA2 6A_ ESEO WORLD CLASS WORLDWIDE General Specifications North America Models LA2 3A2 LA2 4A2 LA2 5A2 LA2 6A2 USA Canada Mexico 115 V 60 Hz Nominal Size 0 9 meters 3 1 2 meters 4 1 5 meters 5 1 8 meters 6 ee 4 External Dimensions 1115 x810 x 1540 mm 1420 x 815 x 1640 mm 1725 x 815 x 1540 mm 2030 x 815 x 1640 mm WxDxH 43 9 x 31 9 x 60 6 55 9 x 32 1 x 64 6 67 9 x 32 1 x 60 6 79 9 x 32 1 x 64 6 Gross Internal Dimensions 955 x 623 x 670 mm 1260 x 623 x 715 mm 1565 x 623 x 670 mm 1870 x 623 x 715mm WxDxH 37 6 x 24 5 x 26 4 dO Gs 24 54 x 72ers SLO xX 24 57 XADE TIO XAD XLII Usable Work Area 0 45 m 4 8 sq ft 0 6 m 6 5 sq ft 0 75 m 8 1 sq ft 0 9 m 9 7 sq ft Tested Opening 228 6 mm 9 228 6 mm 9 228 6 mm 9 203 2 mm 8 Working Opening 274 mm 10 8 274 mm 10 8 274 mm 10 8 248 mm 9 8 Average Airflow BALON 0 53 m s 105 fpm Velocity Downflow 0 35 m s 70 fpm 0 35 m s 70 fpm 0 35 m s 70 fpm 0 33 m s 65 fom Inflow 419 m h 246 cfm 552 m h 325 cfm 685
33. turn air slots or concealed areas which can contain contaminants 23 The cabinet shall be free of sharp edges non functional protrusions bolts screws or hardware and all metal edges shall be deburred 24 The cabinet exterior top shall be slanted to discourage placement of foreign objects and to maintain proper exhaust airflow Ergonomics and Convenience 25 The front sash shall be frameless to maximize visibility and accessible for cleaning front and back Sash glass shall be safety glass 26 The sash counterbalance shall be suspended on two high strength cables and the sash shall lock into position in the event one cable becomes detached 27 Magnetic not mechanical proximity sensors shall work in conjunction with the control system to indicate proper sash position for containment 28 Fluorescent lamps shall be mounted behind the control panel module out of the work zone Electronic ballasts shall be used to eliminate flicker extend lamp life and reduce heat output 29 The UV lamp if installed shall be mounted behind the control panel and away from the user s line of site for protection Note Does not apply to 1 8 meter 6 ft model 30 The UV lamp shall operate via an automatic timer with automatic shut off managed by the microprocessor controller and shall be interlocked with the blower motor and fluorescent lights for safety 31 The cabinet shall be designed with a 10 angled front to optimize use
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