Summary of User`s Manual
Contents
1. Diagnose Comments window at this time 7T The operation ends clicking on Exit This will create a new subfolder for the New Patient and declare it the Active Patient for the session and complete the process of New Patient Declaration In case the Patient s Code is pointing to an already existing subfolder two messages will indicate this situation asking for user s confirmation by clicking on the Right Mouse button ak 4 Installation Copy the file BioMetroPhon_pkg exe in the folder of your preference for installation Double click on it and follow the sequence of windows which will be displayed by the Matlab RunTime Library expansion application 5 MSDOS Auxiliary Window In Windows XP and related versions an auxiliary MSDOS window will appear similar to the one in Figure 5 to collect and show the messages generated by the application especially if execution errors are found In such case collect a copy of this window with CTRL ALTGR PRTYSCR paste this figure with CTRL V in a word file and send it to info glottex com with a brief explanation of the circumstances accompanying the error 14 15 GiATaller Voz_Patologica trabajos ejecutables exe_glottex version 6 3 compiladas oriBioMetrEVA ie Error while evaluating figure KeyPressFcn Error using feval Undefined function figurei_KeyPressFcn for input arguments of type struct Error in gui mainfcn Cline 96 Error in glottex neu cap confi2. Record Length for Vowel a sessions twice the duration established in Record Length for Split Vowels sessions four times the duration established in Record Length for Sentence sessions ten times the duration established in Record Length for Reading sessions During the recording the resulting trace will be shown in the Signal Window as it is being produced second by second and the VU meter will show a scale with the maximum level recorded in each second interval in colors An automatic name will be selected for the record with the following convention 9 15 3 3 lt L yyyymmdd hhnnss session gt wav where L is a label with the same name than the Active Patient s Folder yyyy is a four character label with the current year mm is a two character label with the current month dd is a two character label with the current day hh is a two character label with the current hour nn is a two character label with the current minute ss is a two character label with the current second session is one of the following according with the Record Type selected vowela for Vowel a type splitvowels for Split Vowels sentence for Sentence reading for Reading After the recording a segment of the duration given by the window Analysis Frame ms in the BioMetr amp PhonCONFIG Interface activated by Change Patient on the central part of the recording will become automatically the Active Segment for analysis and lit in green The active segme
3. interface by clicking on Exit This will complete the Patient Selection Process 13 15 IMPORTANT OBSERVATION An associate PatientLog old xls file is also resident in the same Patient s Database Folder containing a back up copy The user is supposed to select only PatientLog xls and not the back up copy which is saved for security purposes only 3 4 Insertion of a New Patient If the user wants to define a New Patient the operation is as follows 1 Open a Patient s List as commented before 2 Activate the New Patient button 3 The Patients Information demanded in the upper left most editable windows is to be filled The user may choose to fill the Name Middle and Surname of the Patient or fill an arbitrary label on the Patient s Code window If the Name Middle and Surname info is supplied the Patient s Code will be filled automatically by the application with the initials of each field Otherwise the Patients Code provided by the user will prevail Optionally the user may provide the age Patient s Age window Selection of gender Male Female button is compulsory If desired the Sampling Frequency may be changed as well as the Record Length This last parameter will be used in configuring the duration of the Record Type sessions as commented before Selection of the Analysis Frame length in ms is also optional 6 An optional text to be included in the Patient s Fields at the time of New Patient Creation may be introduced in the
4. BioMet Phon Tool for the Evaluation of Voice Quality and Biometry User s Manual B Moto o 52 Version 2 3 December 2012 BioMetro Soft S L BioMet Phon Tool for the Evaluation of Voice Quality and Biometry BioMetro Soft S L C Ribera del Loira 42 Ed 2 28046 Madrid Spain Tel 34 91 503 0145 Fax 34 91 403 0099 URL www glottex com e mail info glottex com Copyright and reproduction of the materials in the present User s Manual by any means in any media are restricted by the Copyright holder This document can not be reproduced copied or transferred to other parties without the consent in writing by the Copyright owners 2 15 1 2 3 4 5 6 PE VETTE cise xh sig eh ate 4 What is Glottex Technology seeeesesesesseeseeeeneee eene nnne nnn 4 2 1 The engine behind Glottex amp Technology sseemmHMHM 4 2 2 Whatis the glottal so rce eee er n eee eene xb att eder Rte DE 5 2 3 What is the glottal source useful for eeeeessssssseeeenenee 6 EOM BUDPPIO ea dois ttp Hee pul tine vit a etae me eu E e eR LIT 8 3 1 Management of Patient s Database sss 8 3 2 Storing New Records in the Active Patient Folder sseesssssss 8 3 3 Previous or New Record Analysis from the Active Patient 10 3 4 Insertion of a New Pate
5. amet ters 1 2 3 4 5 6 7 8 Normo Male Model NMM 50 7 1 22k 20120604 101028 mat Normo Female Model NMF 50 7 1 22k 20120604 102019 mat Origin e mail Diagnose Comments SMTP Server Destin e mail EITHER SELECT Book from Patients Books OR Press Browse Patient s Books iTalleriVoz Patologicaltrabajoslejecutableslexe glottexicompiladaslBioMetroPhonPROF 23 32uistriblgrabacionesl Browse Patients Books New Patient Exit Figure 4 Graphical User Interface for the configuration of the tool and the selection of a given patient s folder and profile Use the Change Patient button to change the Active Patient or declare a New Patient The activation of this button opens a new Graphic User Interface as the one in Figure 4 The list of active Patients Books Excel files containing different patient lists which the user may have created before is given in the sliding window Patients Books To select a patient the user must proceed as follows 1 The user must click on one of the active Patients Books to open it for instance on PatientLog xls which is the book by defect This will open the list of available patients labels in the Patients List sliding window 2 Select from the Patients List by clicking on the corresponding label The path pointing to the new patient will be highlighted and transferred to the path editable window in the lower part of the figure 3 The user may now leave the patient selection
6. and shimmer the harmonics noise correlate the biomechanical parameters of the vocal folds dynamic mass viscoelasticity the temporal phonation cycle description the gap alterations and the tremor in voice among others 2 2 What is the glottal source The glottal source is a correlate of the pressure build up of the dynamic pressure in the supraglottal side of the vocal folds as depicted in the figure below a Input Voice T 0 2 a 0 02 0 02 0 04 0 06 0 08 0 1 0 12 0 14 0 16 0 18 b Derivative of the Forward Pressure Wave 0 04 T 0 02 0 L 0 02 0 04 0 06 l l l l l 0 02 0 04 0 06 0 08 0 1 0 12 0 14 0 16 0 18 c Glottal Source T 0 02 0 04 0 06 0 08 0 1 0 12 0 14 0 16 0 18 d Glottal Flow i l l 0 02 0 04 0 06 0 08 0 1 0 12 0 14 0 16 0 18 time sec In the uppermost template a segment of phonated speech voice is presented a The ringing observable in the trace is due to the vocal tract resonances In b the residual obtained when removing the vocal tract resonances is appreciated where the resulting signal is a train of excitation spikes The glottal source obtained from the integration of the glottal residual is depicted in c The Glottal source is characterized by sudden drops of pressure marked by asterisks corresponding to the closure of the vocal folds closing or contact phase followed by a recov
7. below 8 15 e Vowel a for maintained utterances of vowel a lasting several seconds e Split vowels for utterances of trains of vowels like ah eh ih oh uh in stacatto e Sentence for utterances of fixed short sentences as I owe you a letter or any similar e Reading for utterances of read text lasting some minutes as the Rainbow Passage Bcc ON x BioMet PhonPROF ETE TTR f BioMetro Soft l Version 2 5 7 3 July 2012 aD rena Re ri Browse Patient s Folder Change Patient 05 y psg i AN l j IN ia X M LN ETC T8 Ah 1 NON hows T 4 0 005404 E RU Bs sees esu om IMMEL S EST l Record Stop Play All Play Seg J Analyze 05 e i N Grade 0 3 Rough 0 3 Breathy 0 3 Asthenia 0 3 Strain 0 3 Instability 0 3 Annotations Select Browse Patient s Folder or Record 1 2 3 4 Trace No 7 Time s Vowel al x1 Spt vowels x2 Sentence x4 Reading x10 F0 145 52 Hz 35 J i 0 08 0 06 Time s Print amp Send Figure 1 Main Graphic User Interface of BioMetr amp Phon showing the buttons and active windows in analyzing a voice frame The activation of the Record button will open a Recording Session by Activating the recording window on the Signal Window immediately above the Record button with a time length given by once the duration established in
8. cles closest to the middle of the Active Segment is published in detail in the Glottal Source and Mucosal Wave Correlates window in the upper right part of the User Interface Estimations of the Recovery Time tR1 and tR2 the Opening Time tO1 and tO2 and the glottal source Maximum Instant tM are given in the template as well as estimations of the following Glottal Gap Alterations ContGap for the Contact Gap Alteration i e the maximum residual opening defect found during the Closed Phase 11 15 AdduGap for the Adduction Gap Alteration i e the maximum residual counter closing or retract of the vocal folds during the Closing Phase PermGap for the Permanent Gap Alteration i e the maximum residual opening found during the complete phonation cycle due to defective closure in the arytenoidal extreme of the vocal folds An estimation of the Reliability of the algorithmic extraction process and the Average Pitch are published in the editable windows immediately below the Recording Type panel research group p Glottal Sauro ang Flow l GIAPSW nbi UPM AdduGap 0 022 05r PermGap 0 000 GIAPSI UPM Facultad de Inform tica Campus de Montegancedo s n Boadilla del Monte 28660 Madrid Tel 913 367 384 URL http info glottex com e mail info glottex com Application BioMet amp PhonPROF Version 2 3 0 Date 30 1 2013 Time 9 52 FT l it Patient s Name ald Ea EN et ei elles e
9. e eas Upeqes Patient s Code reference tor 0 15 Gender Ll hp 4 Age y kt 0 12 i 1 Phonation Condition 1 2 3 4 5 6 Trace No 7 Time s x10 R2 0 32 1 Recording ABC 20130123 190807 vowela wav Annotations Glottal Source Clipping Glottal Source Quality Analysis 35r 1 Absolute Pitch 174 700 227 890 145 519 2 Abs Norm Jitter 0 004 0 008 0 027 3r 3 Abs Norm Ar Shimmer 0 009 0 036 0 031 4 Abs Norm Min Sharp 0 997 1 003 1 034 25L 5 Noise Harm Ratio NHR 0 512 0 689 0 531 6 Muc AvAc Energy MAE 0 049 0 151 0 212 2 7 MWC Cepstral 1 1151 171 3004 791 2215 915 8 MWC Cepstral 2 674 373 1059 473 2060 303 15 1 0 5 0 01 0 02 0 03 0 04 0 05 0 06 0 07 0 08 Time s Figure 3 Summary of the analysis In the left hand side from top to bottom the description of the tool the patient s data and the statistics of the analysis for the parameters selected are to be found In the right hand side from top to bottom the graphical results for a glottal cycle and the set of glottal cycles analyzed are to be found Values for five Voice Quality Parameters jitter shimmer body mass body stiffness and body mass unbalance are published in the table immediately below These parameters are found to be largely correlated with certain types of dysphonias The deviation values of a distribution of normal speakers normophonic are given in black the actual estimati
10. e seen as the dynamic pressure build up in the pharyngeal side of the vocal folds supraglottal The Glottal Flow may be seen as the flow of air through the vocal folds at a given time instant during the phonation cycle The foundations of the technology are to be found in the Fant Model for Voice production given in the figure below 1 Glottal Excitation Model F z voiced 3 Vocal Tract Transfer Function Pharynx Mouth 2 Frictional Nose Fa z Excitation Model F z unvoiced The speech production system in Fant s source filter model is composed of an Excitation Model 1 for voiced speech 2 for unvoiced speech generating the excitation signal e n with power spectral density given in 5 a filter emulating the Vocal Tract 3 imposing resonances and anti resonances as in 6 to the excitation to generate the speech before radiation sa n and the lip radiation model 4 explaining the evolution suffered from the sound wave from the 4 15 radiation outlet to the microphone to produce the recorded signal s n with power spectral density given by 7 The Glottex Engine produces inverse models for 4 and 3 to reconstruct Sa n and e n from the recorded signal s n In the case of voiced speech the resulting estimated excitation will be n as an approximation to the original glottal source Based on this signal different correlates may be produced as for example the Glottal Flow the distortion parameters jitter
11. ery to dynamic pressure O forming a plateau to expand in a positive raise of pressure during the open phase to drop again during the closing phase The glottal flow d appears as a triangle like burst of flow air during the open phase followed by an almost flat drop during the 5 15 closed or contact phase the Glottal Flow signal shows fluctuations due to uncompensated integration effects Seen in detail the glottal source describes a pattern which is known as the Liljenctrants Fant cycle represented below Glottal Source and Mucosal Wave Correlates for regvoz 508 wav 1 T T T T T T ContGap 0 142 AdduGap 0 056 o 5r PermGap 0 004 Ko B amp E 0 UU E ooo l 79 lt t02 5 316 003 0 56 t1 9 52e 004 0 10 I tR2 2 36e 003 0 25 I 0 5 ent 9 52e 004 0 10 i 1 2 3 4 5 6 7 8 9 Trace No 10 Time sec x 10 Glottal Source Clipping T T T T T T T T 4 E o 3r oO a 2 4 0 l i l l I l l 0 02 0 04 0 06 0 08 0 1 0 12 0 14 0 16 0 18 Time sec The lower template shows a series of phonation cycles one of them being depicted in detail in the upper template blue The pattern shown is known as the Liljencrants Fant cycle The description in the picture starts during the closing instant 0 where the pressure has experienced a drastic drop below 0 Due to the elastic nature of the gas column in the vocal tract a recovery is experienced reaching almost a stable
12. g Cline 425 Error in PChObject euentdataP5glottex neu cap configC figurei KeyPressFcn hObject euventda IUE WESCE LEES EG LO UR TD gt gt Error while evaluating figure KeyPressFcn Figure 5 Console of the application showing an error not captured internally 6 Intellectual Property Glottex Glottex Engine and Glottex Technology are registered names Glottex Technology is the subject of protection under Patent No P201131069 Spain and PTC ES2012 000137 Europe The Intellectual Property Rights holder is Universidad Polit cnica de Madrid Madrid Spain www upm es 15 15
13. his is a very promising line currently under research and development which is already implemented and normalized against a population of normophonic speakers of both genders Currently three cyclicality expressing parameters are derived with tremor detection capabilities 7 15 useful in monitoring Parkinson s Disease progress for instance These parameters are indirectly estimated from the viscoelastic estimates which are known to be directly related to neuromuscular activity of the branches of the laryngeal nerve acting on the transversal and oblique arytenoid and cricothyroid muscles responsible for the vocal fold adduction and abduction cricothyroid transverse and oblique arytenoid and posterior cricoarytenoid Therefore from assymetric and viscoelastic studies the neurological condition of the patient affecting vocal fold tension may be inferred and monitored Singing Voice The use of viscoelastic estimates in monitoring vocal fold performance allows the Speech Therapist or the Singing Trainer or Educator to track the education rehabilitation and care of the professional singer These functions may be directly obtained from the tool BioMet Sing Linguistics The detection of voiced and unvoiced segments in running speech separating the glottal function prosody and modality controlled from the vocal tract influence articulation controlled is very efficient in producing acoustic phonetic labeling as well as prosodic and rhythmic inf
14. ions of the parameters which may show a pathological semantics These evaluations may be used clinically in comparisons of pre post surgery or treatment conditions monitoring success or progress Speech Therapy amp Rehabilitation The same distortions may also be used in evaluating the rehabilitation progress or success in speech therapy Besides estimates of the biomechanical parameters related with dynamic vocal fold mass and viscoelasticity may be used by the Speech Therapist to track gesture modality of phonation pitch elevation air use etc to educate or restore the phonation function in an objective manner These parameters may be stored in EXCELO files for the documentation of validation and contrast of the phonation function Voice Forensics Many of the phonation abnormal conditions are true biometrical marks of the speaker appearing in different realizations in a speech segment which may be used as forensic evidence marks The parameters estimated by the Glottex Engine may be used for automatic evaluation tests among Questioned Evidence against the Suspect s Evidence in a line up Reference Model used as contrast These contrasts are implemented by Gaussian Mixture Models embedded in the tool BioMet Fore allowing Forensic Voice Evaluation Contrasts in a professional manner The application generates different graphical material helping in the documentation of real cases before the Court Neural Pathology Detection amp Monitoring T
15. nt eei erre ie se Ee ees Gir duc Mee 14 HAS Rel O aee 14 MSDOS Auxiliary WIDOOW ig erre Pe ci hae ieee ie ae ees 14 Intellectual Property erre rente nette cennavsedseecsueasacernseecceraens 15 Index 3 15 1 Introduction BioMetro Soft S L is a company created as a start up from Universidad Polit cnica de Madrid Spain founded in June 2011 It initiated its activites after getting the first prize in the VII Contest for the Creation of Companies with Technological Basis in December 2010 act aUPM The field of action of BioMetro Soft S L is the implantation and commercialization of software applications using the human voice for medical biometrical and linguistic applications 2 What is Glottex Technology Glottex Technology is a signal processing engine designed to extract the glottal source from voiced speech It is entirely based on the reconstruction of the inverse vocal tract transfer function to remove its influence from voiced speech The result is a correlate to the dynamic pressure build up in the supraglottal side of the vocal folds which bears behavioral marks on the specific phonation of a particular speaker 2 4 The engine behind Glottex Technology The underlying technology or Glottex Engine is a specific set of computer programs designed to estimate the vocal tract transfer function removing it from voice The results are two signals known as the glottal source and the Glottal Flow The glottal source may b
16. nt may be reproduced with the Play Seg button The limits of the Active Segment will be published in the editable windows immediately below the Analyze button It is possible to change the Active Segment by clicking on the Signal Window area A new 200 ms frame will be highlighted The recording may be stopped at any time with the Stop button The recorded trace may be listened with the Play All button The reproduction may be stopped at any time with the Stop button Previous or New Record Analysis from the Active Patient The Active Patient is the one referenced by the Active Patient s Folder Path in the upper leftmost text window Once this path is open the user may proceed selecting a former record from the Active Patient by means of the Browse Patient s Folder button and double clicking in the desired file name or to analyze a new recording just acquired by clicking on the Analysis button The Active Segment will be used in the analysis The analysis will take some few seconds after which period the following results will be observed A Spectral Contents Window as the one in the next figure will be published 10 15 Relative amplitude dB Relative amplitude dB Voice PSD and Vocal Tract Transfer Function 40F T T T T T T T I I a FFT Pw Spec of Voice 20L b Transfer Func of the VT l A f H l lti d udo oH Jl i WAP ES AM T p 13 146 96 Mu a
17. on for the specific speaker being analyzed given in blue A set of semaphores is lit immediately to the right of the table with the following semantics e green the estimate is within distribution limits e red the estimate is above the distribution upper limit 12 15 e blue the estimate is under the distribution lower limit A Summary of the above information and figures including the patient s available data is published in an independent figure as in Figure 3 This figure shows the specific Active Patient s information in the upper left most part the values of the Voice Quality Parameters and their distributions in the lower middle and a copy of the figures published in the User Interface in its right most part The published figures in pdf format and an Excel file with the complete Voice Quality Parameters 61 different including dispersion cepstral biomechanical and cyclical are stored in a folder named results within the Active Patient s Folder if the Save Results button under Analyze is activated Doc MEEOT t A c1 3 p EE Bioffiet amp fPhonCOffIG GBioffletro Soft L Version 2 5 7 5 July 2012 Patients Books PatientLog old xis gt PatientLog xis Patient s Name Patient s MidN Patient s SurN Patient s Age Patient s Code reference Sampling Freq Hz 44100 Record Length s 10 Patients List Analysis Frame ms 100 Visible Par
18. ormation which can be used for advanced linguistic studies This information is provided by a sophysticated tool as PangurBan ACAD 3 BioMet amp Phon It is a powerful application specifically conceived for the Analysis of Voice Quality by Voice Care Practitioners and Speech Therapists It is based on a General User Interface version 2 3 running Glottex Engine version 7 3 as the one shown in Figure 1 The application incorporates the following features 3 4 Management of Patient s Database Patients Records are organized by Patient s Folders using a Patients Name Convention Other folders and records may be also processed assuming they are stored as wav audio files The main functions available under the Patient s Database Management Interface are Browse Patient s Control button which allows opening a specific Patient s Folder Change Patient button which allows declaring a New Patient a New Folder or simply changing the current Active Patient As this procedure opens in a new User Interface it is described later 3 2 Storing New Records in the Active Patient Folder The Active Patient is the one referenced by the Active Patient Folder Path in the upper leftmost text window Once this path is open the user may proceed acquiring a new record to be included in the Active Patient s Folder by means of the Record button Prior to activating this button the user is expected to select one of the four Record Type buttons immediately
19. s etc The second dysphonic condition has to see with deficient or incomplete closure resulting in air escape during the closed phase This would result in an inefficient air use fatigue excessive turbulence and irregular L F pattern with loss of closure sharpness in the negative salience of the glottal source peaks irregular or too slow recovery phase unstable resting phase or distorted abduction and adduction sub phases Defective closure has to see with uni lateral lesions of the kind commented or with bi lateral lesions making closure difficult as nodules Another source of incomplete closure has to see with a lack of tension in the crico arytenoidal muscle cartilage structure leaving a permanent gap or escape affecting the arytenoidal side of the vocal folds This results in a permanent gap condition producing airy voice and a loss of efficient air use All these conditions may be checked by the graphical presentation of the glottal source produced by Glottex Engine as well as from the numerical distortion parameters as jitter shimmer harmonic noise ratio biomechanical unbalance cycle time and gap alterations which are produced by the application Their use in Phoniatry have to see with the comparison of the parameters against the normal distributions and limits of these obtained from normophonic speakers of both genders The tool BioMet Phon renders these estimations and contrasts and plots them in semaphores which alert on deviat
20. t its 48 15 92 14 48 A A T 2 x o ig if l Qs 9475776 5 2 851 duisi ifi o4 40 60 ls 80 l l l l J l L l l l 1000 2000 3000 4000 5000 6000 7000 8000 9000 10000 11000 freq Hz Glottal Source PSD T T T T T T I I I I a FFT Pw Spec of Glottal Source 40H b Pw Spec of Glottal Source ProfileH NN i TH M il 0 Y IN MM uil MM T nu 4 yt IAAT Ah at 20 40r 1 l l l l l l l l i 1000 2000 3000 4000 5000 6000 7000 8000 9000 10000 11000 freq Hz Figure 2 Spectral Contents Window Upper template in blue the Fourier Spectral Density of the voice signal in red the LPC Transfer Function of the Vocal Tract Lower template in blue the Fourier Spectral Density of the Glottal source in red the average LPC profile of the same signal background This window shows the Fourier Analysis of the Active Segment in blue and the LPC spectral envelope of the vocal tract in red marking the positions in Hz and the relative heights of the voice formants in dB The average behavior of the glottal source will be marked in green It is very important to notice that the estimations of the vocal tract spectral behavior is free of the glottal source influence which makes it a very precise estimation compensated in spectral tilt and free of the Glottal Formant A frame with the glottal source cycles contained in the Active Segment is published in the Glottal Source Clipping window in the lower right part of the User Interface One of this cy
21. value near 0 at tR1 This is known as the recovery phase From there on till tO2 opening instant the dynamic pressure stays close to 0 resting sub phase as the vocal tract is closed by the vocal folds except for slight escapes of flow represented by the green line During the open phase from tO2 till the end of the cycle a burst of flow in green is expelled The pressure raises during the first part of the burst injection till tM abduction sub phase At this point the vocal folds initiate an approximation adduction sub phase to close the vocal tract again which shows a steady and sharp decay in pressure till the end of the cycle tC This is the L F cycle closing closed phase 0 tM composed of recovery phase 0 tR1 and steady closure phase tR1 tO2 and open phase composed of abduction sub phase tO2 tM and adduction sub phase tM tC to be followed by a new closing 2 3 What is the glottal source useful for Laryngology The glottal source expresses two different phonation conditions which have strong correlates with dysphonia or pathology these are cyclic asymmetry and defective closure The first condition shows remarkable 6 15 dissimilar neighbor phonation cycles i e each vibration pattern is more similar each two cycles than to their neighbor patterns Asymmetry may be due to anatomical differences to unilateral partial paralysis to unilateral neuromuscular path lesions or to unilateral organic lesions polyps cyst
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