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1. Screen Displaying Variables from Box 1 A Array B Array C Array Po z Named Vars F G H k Vars 0 000 0 000 0 000 0 000 K L M N 0 000 0 000 0 000 0 000 Bekresh P Q R S 0 000 0 000 0 000 0 000 Issue u v W X cl 0 000 0 000 0 000 0 000 sos Zz 0 000 S Help Display Data from Box Additional Boxes to Update D from Box 1 ot a 0 000 A SelectAll Deselect All Figure 4 12 Named Variables Display Displaying Named Variables from Box 1 Fixed Ratio Value 10 000 Named Vars Session Length min Maximum Number of Infusions 10 000 vas Time out Following Infusion sec 60 000 Refresh Infusion Time sec 2 000 ee SoftCR Data Array Yes 1 No 0 1 000 Close Help Display Data from Box Additional Boxes to Update ey gi Select All Deselect Al PRODUCT NUMBER AND DESCRIPTION To change variables prior to issuing the Start command select Configure Change Variables or click the 4th tool bar item AX to reveal the window shown in Figure 4 11 If a blank table is first presented click the box number that is being used in the Display Data from Box area of the screen By clicking additional boxes in the Additional Boxes to Update section changes made to a single box are automatically loaded on all of the boxes selected The value of any simple variable or data element may be viewed from this screen Click an array on the table and each elem
2. mpc Remember if a new mpc file name is created and a macro is being used to load boxes the file name in the macro also must be changed 4 Translate and compile the new or changed file as described previously and run MED PC IV Use the Change Variables screen to view confirm the new values 11 DOC 027 Rev 1 4 Copyright 2012 MED Associates Inc CHAPTER 6 UNDERSTANDING THE DATA Selecting Annotated on the File options page during hardware installation produces a raw data file similar to the one shown below Data files are located in C MED PC IV Data unless an alternate path was defined during hardware installation They may be opened with note pad word pad or any word processor however be sure they are always saved unformatted in case a data extraction utility such as MPC2XL might ever be used The header information should be self explanatory Data File Formats are explained in detail in the MED PC IV User s Manual Sample Data File File Start Date 11 31 08 End Date 11 31 08 Subject 0 Experiment 0 Group 0 Box 1 Start Time 8 54 35 End Time 9 40 38 MSN Drug Self Infusion D 24 000 E 0 000 F 6000 000 G 200 000 H 0 000 I 78 000 J 0 000 K 0 000 i 0 000 M 0 000 N 0 000 O 0 000 P 0 000 Q 0 000 RA 0 000 S3 0 000 Ts 3964 000 U 0 000 V 0 000 W 0 000 Xe 0 000 Yi 0 000 Z 0 000 A 0 10 000 Dis 1 000 B 0 20 000 54 4 000 10 0 000 C 0 0 500 es 5965 100 1
3. reinforcement nnnn 6yz set event pen to level 1 up If the fixed ratio is 10 default value then an infusion takes place after every 10 presses on the active lever Response time values are represented in SoftCR Pro ticks To calculate when a response has occurred in real time multiply the number by 0 01 sec since SoftCR Pro s resolution is 10ms 0 01 sec For example value in C 1 is 742 ticks 742 multiplied by 0 01 sec yields 7 42 seconds This is when the first response occurred in real time after the program had started Cs 0 0 500 742 600 0500 194 600 0 500 Die 5965 100 460 100 15 100 2164 100 206 100 LOs 18 100 456 600 0 2500 6034 600 0 500 15 5 47 600 0 500 14 600 0 500 15 600 20 0 500 16 600 0 500 37 600 0 500 253 31 600 0 500 207 600 0 500 62 600 30 0 500 583 600 41 100 34 100 22 100 35 4 0 200 13 100 16 100 94 100 885 100 40 3717 600 0 500 429 600 0 500 3034 100 Array C With Labels Data is shown through row marker 15 only c 0 SoftCR is activated Active Lever is pressed 5965 100 Active Lever is pressed 10 Marker c 15 Inactive Lever is pressed Row Marker 152 47 600 18 100 c 1 Inactive lever is pressed 742 600 Active Lever is pressed 460 100 Inactive Lever is pressed c 16 Set Pen to Level 0 0 500 456 600 c 2 Set Pen to Level 0 Active Lever is pressed Set Pen to Level 0 17 Inactive Lever is pressed 14 600 1
4. 0 18 100 153 47 600 20 0 500 256 31 600 30 0 500 353 0 200 40 3717 600 C MED PC IV DATA 2008 11 31_ 16h37m Subject 0 30 742 460 456 500 16 500 583 T3 500 000 250 000 600 100 600 600 600 100 10 000 3 000 2 000 0 500 15 100 0 500 14 600 207 600 41 100 16 100 429 600 12 60 194 2164 6034 500 ITa 500 34 94 500 000 000 600 100 600 600 100 100 0 000 0 500 206 100 0 500 15 600 62 600 22 100 885 100 3034 100 DOC 027 Rev 1 4 Copyright 2012 MED Associates Inc OCIATES INC PRODUCT NUMBER AND DESCRIPTION Breakdown of Sample File Working Variables The following working variables are shown immediately following the header information D 24 000 Session Count Down Timer in minutes will be 0 at the end of the session unless B 7 10 E 0 000 Not Used F 6000 000 Time Out in MED Ticks tick 10ms 0 01 sec 6000 ticks 60 seconds G 200 000 Infusion Time in MED Ticks tick 10ms 0 01 sec H 0 000 Not Used Le 78 000 Subscript for the IRT Array C indicates number of elements in I array J 0 000 Not Used K 0 000 Not Used L 0 000 Not Used M 0 000 Not Used N 0 000 Not Used O 0 000 Not Used P 0 000 Not Used Q 0 000 Not Used R 0 000 Not Used Si 0 000 Not Used T 3964 000 Elapsed Time in 0 01 second Increments for SoftCR Pro Data U 0 000 No
5. 5 0 500 c 3 Inactive Lever is pressed 194 600 Active Lever is pressed 2164 100 Inactive Lever is pressed c 18 Set Pen to Level 0 0 500 DOC 027 Rev 1 4 Copyright 2012 MED Associates Inc 6034 600 c 4 Set Pen to Level 0 Active Lever is pressed 206 100 Set Pen to Level 0 0 500 c 19 Inactive Lever is pressed 15 600 CHAPTER 7 USING SOFTCR PRO The Drug Self Infusion procedure stores IRT data in array C that may be used by the SoftCR Pro Cumulative Recorder program to generate a graphical record on screen or to print a Cumulative Record after the data has been collected Each element in this Cumulative Record data array consists of two components The integer value or value to the left of the decimal point is the time component The decimal value or value to the right of the decimal point is a SoftCR Pro code component Refer to the SoftCR Pro User s Manual for further information Time Components Time components may be Relative or Absolute In a Relative file the time component of a given data element is equal to the elapsed time since the previous element In an Absolute file it is equal to the elapsed time since the beginning of the Record The elements used in Drug Self Infusion are all Relative with a resolution of 0 01 seconds 10 milliseconds Control Code Components The control code component indicates whether the element is a Response Step Reinforcemen
6. Click Next to finish loading the box or Previous to correct errors The Alter Session Parameters Screen shown in Figure 4 6 is the next screen to appear and is an important screen for the researcher The Alter Session Parameters screen allows the researcher to alter the parameters by which a procedure executes Any of the variables may be changed on this form Simply highlight the value to change and then enter the desired value The Send Start Command Screen appears next Figure 4 6 Alter Session Parameters Screen Fixed Ratio Senne Session Time Minutes Timeout Following Infusion Sconce Maximum Number of Infusions Infusion Time SoftCr Data Array Yes 1 Nao In this example only 1 box is described in the Hardware Configuration so Figure 4 7 will appear next If more than 1 box is in the Hardware Configuration then Figure 4 8 will appear In both cases the screens are where the researcher decides to either load more boxes send a start signal to boxes that are already loaded or enter the MED PC IV run time environment without 6 DOC 027 Rev 1 4 Copyright 2012 MED Associates Inc MED ASSOCIATES INC PRODUCT NUMBER AND DESCRIPTION sending a start signal by selecting I am finished with the wizard This option results in the screen shown in Figure 4 9 Figure 4 7 Send Start Command Screen for Single Box Configuration Figure 4 8 Send Start Command Screen for
7. Multiple Box Configuration DOC 027 Rev 1 4 Copyright 2012 MED Associates Inc MED ASSOCIATES INC PRODUCT NUMBER AND DESCRIPTION Figure 4 9 MED PC IV Runtime Screen i MED PC IV la x Fie Configure View Macros Help Sole alalt S Elm i 2 Box Subject_ Experim Group _ Load Program a ee Ee hopi heh fia 7 Fi Time Out 60 00 Infusion Time 2 00 1 le amp Wizard for Loading Boxes Open Session 7 6 19 2008 2 09 26 PM Zi If all settings are correct a Start command may be issued in one of two ways One is to select Configure Signals and the other is to click the 5th tool bar item that resembles a keyboard to reveal the window shown in Figure 4 10 To make additional changes to the variable values proceed to the next section Figure 4 10 Send Start Signals to Boxes Send Signals to Boxes 2 x Command to Issue Issue START Command Issue Issue K Pulse Synchronize Occurence Close Hel Simulate Response tal Hep Boxes M i Select All Deselect All Click a single box multiple boxes or Select All followed by the Issue button to start the procedure Click Close to remove the window from the screen There is no reason to select Synchronize Occurrence DOC 027 Rev 1 4 Copyright 2012 MED Associates Inc MED ASSOCIATES INC Viewing Changing Variable Values Figure 4 11 Change Variables
8. ae MEO associates inc instrumentation and software for research DRUG SELF INFUSION APPLICATION MED STATE NOTATION PROCEDURE SOF 700RA 10 USER S MANUAL DOC 027 Rev 1 4 Copyright 2012 All Rights Reserved Med Associates Inc P O Box 319 St Albans Vermont 05478 Phone 802 527 2343 Fax 802 527 5095 www med associates com PRODUCT NUMBER NAME PRODUCT NUMBER NAME Table of Contents Chapter 1 TMEFOAU CUO ssi ince csckcdccssascasaatecenssgtansesesesasssnseanscbustenasdestansena cothtiesnsncsnades 1 Chapter 2 Protocol Overview cc ccesscssssecssssecssseeessseeessseessseeeessseesssseeesseeeesaees 2 Chapter 3 Translate and Compile ee ccsssecssseeesseeessecessscceessseeesseceesseeeesaees 3 Chapter 4 Running the Protocol cee ccsseecesseecssseeessseeessceeesseceessseeesseeeeaees 4 Viewing Changing Variable Values cccccsssssssscsseseessseseeseeesseseeseeecsesessesecsessesesecsesaseeseesasas 9 MAGCHOS occsats snceetsousoysspevatecnadetball ise nautieseiaedeeaidials DA alee DAN alee 10 Chapter 5 Modifying the Medstate notation ccesecssseessceessecessseeeeee 11 Chapter 6 Understanding the Data 0 ee ccssecssreessseeesseceesseceesseceesseeeenes 12 Sample D ta Fae tects a ccna set ahead ae RP te tl elk de ees ten asl dd OOo eee 12 Breakdown of Sample File cc cecseshet ata sennaa tater paeatad alah aettee hada lath ci teased Gl tit cal lah ae a
9. d during this process refer to the on screen help menu the MED PC IV Programmer s Manual the MED PC IV User s Manual or contact MED Associates Inc for assistance Figure 3 1 Trans IV Control Panel for Translating and Compiling MedState Notation Code iy Specify Files to Translate drug self infusion mpc Build No Trans Exclude J OK X Cancel DOC 027 Rev 1 4 Copyright 2012 MED Associates Inc MED ASSOCIATES INC PRODUCT NUMBER AND DESCRIPTION CHAPTER 4 RUNNING THE PROTOCOL First time users may choose to use the Load Wizard while more experienced users may prefer to go directly to the run time screen to load the Drug Self Infusion application Clicking the MED PC IV icon from the Start Programs list or desktop brings up the MED PC Experiment Loading Wizard s Welcome screen shown in Figure 4 1 If it is not necessary to run Load Wizard then deselect the box labeled Run this expert automatically when starting MED PC Close this screen by clicking the Close button Closing this screen immediately reveals the MED PC Run Screen shown in Figure 4 9 Click Next to proceed with the wizard The display shown in Figure 4 2 will appear Figure 4 1 Load Wizard Main Screen Select the boxes to load and click Next Figure 4 2 Box Selection This is where the procedure to be run is selected The screen displays a list of all the currently compiled procedures Select the procedure to be ru
10. e file Drug Self Infusion mpc or any mpc file supplied for SOF 700RA 10 before launching MED PC for the first time Before proceeding with this manual print a copy of the mpc file Drug Self Infusion mpc In the protocol lines beginning with a backslash indicates comments that help identify key elements of the code and explain the function of each program step DOC 027 Rev 1 4 Copyright 2012 MED Associates Inc CHAPTER 2 PROTOCOL OVERVIEW The standard experimental chamber for this procedure includes a drug infusion catheter lever press device house light and stimulus light During the procedure the stimulus light is illuminated to signal the availability of reinforcement and drug infusion is administered following the completion of a user defined fixed ratio FR schedule Drug infusion is followed by a timeout period during which the stimulus light is off and no reinforcement is available The house light remains on throughout the entire procedure The default FR schedule is set to deliver reinforcement after 10 responses The timeout period following drug infusion is set to 60 seconds This value is defined in seconds if a timeout of 10 minutes is desired then the timeout should be set to 600 Set this value to zero if no timeout is desired Responses are recorded during the timeout period but these responses will not count toward the FR schedule The default session time is 30 minutes and the default maximum number o
11. ent in that array can be viewed To change a value simply highlight and replace the value in the lower right hand box or use the up down arrows to increment by 1 For the change to take effect click Issue Click Named Variables to produce the display shown in Figure 4 12 Edit these variables to best suit the experiment DOC 027 Rev 1 4 Copyright 2012 MED Associates Inc Macros To create a macro commands will be entered manually and then the keyboard functions will be recorded Once the commands are recorded as a macro a number of macros can be created with the macro editor The following example illustrates how to load Box 1 and change Session Time to 60 minutes Begin by opening MED PC IV and then go directly to the run time screen Close the Load Wizard if present Before loading or opening the procedure click Macro on the main menu and select Turn On Macro Recorder or click the 8th tool bar item cassette tape icon A note on the bottom of the display indicates that the recorder is running Proceed to load Drug Self Infusion mpc To do this click Files on the main menu and select Open Session or click the 2nd tool bar item open book icon Change the variables using any of the methods described above When all settings have been made turn the recorder off again by using the main menu or tool bar Save the macro with a distinctive easily recognizable name The example in Figure 4 13 is named Drug Self I
12. er Array B Raw Data Fixed Ratio Value SoftCR Data Array Yes 1 No 0 30 000 A 1 Session Length min 30 000 10 000 A 2 60 000 A 3 2 000 A 4 Max Number Time Out Following Infusion Time of Infusions 10 000 Infusion sec sec Array B is used for counters for data variables and may change as the session runs All elements will be incremented according to animal s responses B Oi 20 000 5 4 000 10 0 000 Array B With Labels B 0 Right Lever Responses at FR Row Marker LL Responses at Marker Timeout Marker Not used 10 0 000 4 000 250 000 B 1 RL Responses at infusion Time in Fixed Ratio in seconds 250 000 3 000 2 000 B 2 RL Responses at Time out Number of Infusions 14 20 000 0 000 B 3 Left Lever Responses at FR Responses minute at Fixed Ratio 0 000 0 000 B 4 LL Responses at Infusion DOC 027 Rev 1 4 Copyright 2012 MED Associates Inc MED ASSOCIATES INC PRODUCT NUMBER AND DESCRIPTION Array C SoftCR Pro Data Array C contains summary information for SoftCR Pro The value of every variable conforms to the Data Element Format described in the SoftCR Pro User s Manual nnnn 5Syz indicates that the event pen is set to level O down or at baseline In this program event pen is set to level 0 every time a response on inactive left lever occurs Nnnn lyz response nnnn 2yz
13. f infusions is set to 10 The session will end when one of these two conditions is met Infusion time is automatically set to 2 seconds Remember that this value is defined in seconds when modifying it By default the lever presses and rewards are recorded in the C array for later viewing in Med Associates Soft Cumulative Recorder SoftCR Pro Correct lever presses are recorded as steps rewards as pips and incorrect lever presses as event pens DOC 027 Rev 1 4 Copyright 2012 MED Associates Inc OCIATES INC PRODUCT NUMBER AND DESCRIPTION CHAPTER 3 TRANSLATE AND COMPILE Programs written in MedState Notation need to be translated into PASCAL before they can be run in the Drug Self Infusion Application The MED PC IV Programmer s Manual explains how to accomplish this translation in more detail Make sure that a copy of the file Drug Self Infusion mpc or whatever file is being translated is present in the directory C MED PC IV MPC Double click the Trans IV icon on the Start Programs list or desktop and select Translation Translate and Compile to produce the screen shown in Figure 3 1 Highlight the files to translate then click Make Once the desired files are selected click OK to start the translator It should automatically parse the MedState Notation and then open to a DOS screen to compile the Pascal code Depending on the speed of the computer each of these steps may not be visible If any problems are encountere
14. n and then click Next DOC 027 Rev 1 4 Copyright 2012 MED Associates Inc MED ASSOCIATES INC PRODUCT NUMBER AND DESCRIPTION Figure 4 3 Select a Procedure to Load The Box Procedure Selected Screen will display next as shown in Figure 4 4 The purpose of this screen is to allow annotations to be added to the data file that is produced by MED PC IV These annotations will help identify the Subject Experiment and Experiment Group upon which data was collected Comments can be added here as well and the data file can be given a customized file name to help identify it from other data files Enter the information desired and click Next Figure 4 4 Box Procedure Selected Subject tect Experimen t Self_Infusion_1 Group Grupi Comments Drug Self Infusior Optional Custom Filename Sl_Experiment_Subjecti_Groupt g The next screen to appear is the Review Choices screen as seen in Figure 4 5 This is a method of confirming that the information entered is correct If it is not correct select Previous and edit the information If it is correct select Next to continue DOC 027 Rev 1 4 Copyright 2012 MED Associates Inc MED ASSOCIATES INC PRODUCT NUMBER AND DESCRIPTION Figure 4 5 Review Choices Screen Review the data below Box 1 Procedure DRUG SELF INFUSION Subject Subject_1 Experiment Self_Infusion_1 Group Group_1 Comment Drug Self Infusion Filename Sl_Experiment_Subjectl_Group1
15. n 13 Chapter 7 Using SOftCR Pro uuu eee ecseccssecesseeesseeeessseesssseeessseeessseesseeeeseeeeees 16 Time COMPONEN e denlandhcs inde Na E et eee N 16 Control Code Components asneira a a et N 16 Data Element Formater te ean ast en e a E A E EA E E E olay 16 EXIM PIG of So OR iO aaa ea E Ea a a a aa ea ra e TA aA Aana 17 Appendix A Contact Information ccccecsssecsscceessececssecessaceessaeeesseeeesaeeeees 18 CHAPTER 1 INTRODUCTION The latest version of MED PC IV and off the shelf programs such as the Drug Self Infusion Application make it easier than ever to run experiment protocols without developing a separate MedState Notation program This manual explains the process of running the standard protocol and provides examples of editing and modifying the code The manual also includes detailed explanations of all the elements in the raw data Refer to the MED PC IV User s Manual for the installation of the MED Associates interface drivers the MED PC IV Software and the Delphi Compiler and for instructions on Hardware Configuration Hardware Configuration is a software utility that comes with MED PC and is used to assign the inputs and outputs in the interface cabinet Data file structure file saving format and other related options are also determined by this utility Refer to the MED PC IV Programmer s Manual for detailed instructions on translating and compiling an application Trans IV must be run on th
16. nfusion6Omin mac since it changes the session time to 60 minutes Figure 4 13 Drug Self Infusion6Omin mac LOAD BOX 1 SUBJ 0 EXPT 0 GROUP 0 PROGRAM DRUG SELF INFUSION SET Session Length min VALUE 60 MAINBOX 1 BOXES 1 Once this macro is built use the macro editor to make changes to timeout periods or the maximum number of infusions Review the Help file on screen or the MED PC IV Programmer s Manual for more information on macros and the features offered A Start command or message box followed by the Start command can be added to the macro 10 DOC 027 Rev 1 4 Copyright 2012 MED Associates Inc CHAPTER 5 MODIFYING THE MEDSTATE NOTATION Permanent changes may also be made to the MedState Notation code To make the same change to the stimulus duration as shown above in the Macros section complete the following steps 1 Open Trans IV and select File Open from the main menu to place Drug Self Infusion mpc into the text editor 2 Scroll down to approximately line 90 note the line counter in the lower right hand corner of the editor to reveal the code shown in Figure 5 1 Figure 5 1 Drug Self Infusion mpc Lines 87 90 Set default values for Fixed Ratio Session Length Maximum Number of Infusions Time Out and Infusion Time 0 001 SET A 0 30 A 2 10 A 3 3 Change A 1 30 to A 1 60 and save the changes with the same or a new file name such as Drug Self Infusion _60min
17. s is a Fixed Ratio of 10 schedule the subject was reinforced after 10 responses on the Right Lever A reward is recorded as a Pip or a hash mark on the red line The colored traces at the bottom of the screen are called Event Pens and can be used in a variety of ways for a number of purposes The Event Pens can go up and down creating quick spikes like the ones seen here or long plateaus that represent certain periods of time during an experiment Here the Event Pen 0 records a Spike for every incorrect response that is made 17 DOC 027 Rev 1 4 Copyright 2012 MED Associates Inc MED ASSOCIATES INC PRODUCT NUMBER AND DESCRIPTION Figure 7 1 Example of a Drug Self Infusion Schedule Shown in SoftCR Pro SoftCR Pro 2008 11 12 2 File Preferences Plot view Wind Help D w amp R P Start 112me 8 5435 Mi Experiment 0 Start Date 11 12 08 File C MED PC Iv Data 2008 11 12 Subject 0 Start Time 8 54 35 Source Code drug self infusion Group 0 End Date 11 12 08 Comments 1 End Time 9 04 36 v 0 00 00 30 0 00 01 00 0 00 01 30 0 00 02 00 el Appendix A Contact Information Please contact MED Associates Inc for information regarding any of our products Visit our website at www med associates com for contact information For technical questions email support med associates com 18 DOC 027 Rev 1 4 Copyright 2012 MED Associates Inc
18. t Pip Pen Reset Event Pen Up or Event Pen Down element Up to 10 Event Pens 0 9 and 10 Trace Pens 0 9 may be specified in MED PC In addition Resets may be made with the Pen Up no vertical tracing or Down Additional coded information may be possible in the future Data Element Format Each data element must conform to the following format nnnnn xyz Where nnnnn Time Component xyz Control Code Component x Datum Type y Datum Index z Don t Care Digit NOTE If there are more than three numbers past the decimal point then the array will be considered invalid and will be ignored by SoftCR Pro 16 DOC 027 Rev 1 4 Copyright 2012 MED Associates Inc Allowed datum types and indices are y Index 0 9 for Multi Trace Files NULL for Single Trace Files y Index 0 9 for Multi Trace Files NULL for Single Trace Files nnnnn 4yz nnnnn 5yz nnnnn 6yz nnnnn 7yz nnnnn 8yz nnnnn 9yz Unused Set Event Pen To Level 0 Down or at baseline where y Event Pen Number 0 9 Set Event Pen To Level 1 Up where y Event Pen Number 0 9 Unused Unused Unused Data in the array being plotted that does not conform to the above rules will be ignored Example of SoftCR Pro Figure 7 1 is an example of what Drug Self Infusion will look like in SoftCR after an experiment is run The red line records a Step for every correct response that is made Since thi
19. t Used Va 0 000 Not Used W 0 000 Not Used X 0 000 Not Used Y 0 000 Not Used Z 0 000 Not Used Arrays The arrays are presented in rows of 5 elements each The first row begins with element 0 and ends with element 4 the second row begins with element 5 and ends with element 9 etc Each row begins with an element marker followed by a colon 0 5 10 15 20 25 30 etc Size of Array C was set to 10000 with the DIM command which means that Array C was defined for 10001 data points Under MED PC Version IV this array may be enlarged up to 1 million elements however 10 000 should be more than adequate for this application An end of array seal 987 987 will limit the saved file to only those elements used during the running of the procedure Each array has been defined in the comments section at the beginning of the mpc file That information was used to add the following labels to each array The lines were expanded to make room for the labels See MPC2XL for producing labeled data files with all or just some of the information below 13 DOC 027 Rev 1 4 Copyright 2012 MED Associates Inc MED ASSOCIATES INC Array A Definitions of Control Variables PRODUCT NUMBER AND DESCRIPTION Array A contains the values of each of the control variables The default values for each of these variables are shown below 0 10 000 5 1 000 Array A With Labels A 0 Row Marker 10 000 Row Mark
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