neonatal manual for standard newborn care
Contents
1. and child Experimental Protocol 1 Pre experiment tasks a b C d e Ensure battery of NECBOX is charged Install front ends and back ends into cap according to pre defined format in the table below fig 3 1 Fp2 Fz Cz Pz T4 T6 T3 T5 0 N MU 3 0 n2 Attach stick on electrodes to DRL amp CMS cables fig 4 Ensure headphones amp antenna are fixed on channel 1 Ensure the antenna transmitter is connected to the computer through the headphone jack Ensure computer volume is set on level 1 or 30 Ensure the computer is connected to the internet either via a broadband cable or Wifi 2 Experiment a Cap Place the cap on the child s head Attach the 2 reference electrodes to the child s mastoid by peeling off the back sticker Both electrodes should be on the same mastoid so both on right or both on the left mastoid and they should ideally be as close together as possible Please paste the electrodes on the mastoid and not on the angle of the jaw or the neck on the angel of the jaw or neck you get a lot of artefacts in the EEG data when the child moves Put the headphones on you will see a red light come on Double check that the transmitter is connected to the computer via the headphone jack of the computer you will see a green light on the transmitter base One and a half minute into the recording after you perform the steps below please recheck that the green light is still on on the tra2. other prosthesis The use of the device could result in these cases unsafe 7 Inthe case of malfunction immediately contact the manufacturer or the distributor 8 The device is not protected against excessive moisture or immersion in liquid In the case of the device becoming wet or damp do not use it and immediately contact the manufacturer 9 Do not touch the device while EEG monitoring is on Always unplug the USB power supply from the device prior connecting electrodes to the subject 10 The device will not work when charging the battery 11 Never use the device or install the electrodes on the head of the patient while connected to the power network 12 The device must be used only with Ag AgCl electrodes recommended by the manufacturer 13 The device is not protected against other high frequency devices To avoid risks place the CMR DRL as far as possible from the s and return electrode of the high frequency device 14 The device is wireless and might be affected by other RF devices The device needs special EMC precautions It needs to be used according to user manual information regarding EMC 28 15 The EMC emissions and immunity has been tested using the 10 wires or 12 wires 34 cm cables provided with the system The use of other cables or electrodes than the ones delivered with the product might produce higher EMC emissions and less EMC immunity 16 The device cannot be beside used or piled under other equipment If
3. such usage is needed check the normal configuration 17 The device can only be used in healthy skin without wounds Conditions of use Enobio must be used in normal temperature and pressure conditions T range 10 45 C humidity 20 90 atmospheric pressure 700 1000 hPa Technical Specifications EEG functionality Number of Channels 8 or 20 Channels Bandwidth O to 125 Hz Sampling rate 500 SPS Resolution 24 bits 0 05 microVolt Measurement Noise 1 uV RMS Input impedance 1000 Mohm minimum Allows for Stimulation simultaneously Other Technical Specifications Communication Bluetooth 2 1 Output EDF ASCII data files or tcp ip raw data streaming 3 axes accelerometer microSD card for off line storage Operating time 8 hours for EEG only Dimensions 60 x 85 x 20 mm Weight 65 g Compatible with Windows 7 Windows Vista Windows XP MAC OS X Product Description See Fig 21 23 below for product description 29 1 USB connector for charging battery Must not be on when EEG recording is in progress 2 Ec 2 Power ON switch O indicates OFF position and allows for charging of the battery indicated ON position no charging possible Fig 21 4 12 EEG connector and reference signals 5 8 EEG connector and reference signals M 3 MicroSD card socket 14 5 r 3 Fig 22 30 6 LED indicates norm
4. the neoprene cap and the auditory novelty program into its software to automate the presentation and recording of the same Methods Each child will be seated in his her mother s lap in a partially lit quiet room facing a computer monitor approximately 50 cm away The Enobio cap containing 8 electrodes will be placed over the child s head and a reference electrode will be clipped to the mastoid region of the Enobio cap The Enobio was customized for the purpose of this study to a fit the cranial dimensions of a two year old child and b integrate wireless headphones into the cap The Enobio cap will contain dry EEG placed at sites Fz Cz Pz T3 T4 T5 and T6 according to the international 10 20 system of electrode placement Fig 2 Eye movements and blinks will be monitored by the Fp2 electrooculogram electrode also integrated into the Enobio cap The child will be asked to watch a series of cartoon video clips on the computer screen The cartoons will have their audio clips removed and instead of the cartoon s audio the experimental auditory stimuli will be presented to the child via the wireless earphones The presentation of these stimuli and the recording digitization and processing of the EEG data will be carried out automatically with the Enobio software The Enobio s electrodes take 2 minutes to calibrate when placed on the child s head during which a baseline EEG is recorded for 2 minutes before the auditory no
5. these central hearing impairments in childhood are rarely implemented These auditory deficits have been collectively termed auditory processing disorders in order to incorporate in the term the interaction between peripheral and central pathways Disturbances in auditory processing are an important indicator of disturbances in sensory neurodevelopment in children and measurement of a child s ability to detect and assimilate novel auditory stimuli may be used to examine subtle differences in auditory processing In addition higher prevalence of auditory processing disorders are reported in preterm babies children with a family history of deafness intra uterine infections and epilepsy A number of tests to assess auditory function in children were considered These included the use of audiometry acoustic reflex thresholds otoacoustic emissions communication inventories and the measurement of evoked response potentials ERPs to auditory stimuli It was decided that for use in the follow up study of the INTERGROWTH 21st Project the test of auditory assessment should Be suitable for use on children at 24 months of age Assess the entire auditory pathway and not just elements of the same Yield information about an auditory threshold and amplitude and latency of responses Assess subtle changes in auditory processing between individuals Be easy to administer without specialist training Beinternationally valid Be ra
6. this folder Please paste ONLY the zip files and not the info files 24 Data of visit DOM YY YY 1408 2013 em loflow up study Fig 20 Close the software 11 14 18 Biuetootb D Banery E E Signal Monitoring 25 Maintenance Silver Silver Chloride Ag AgCl electrode instructions Precautions for handling electrodes Electrodes should not come into direct contact with metals as this may cause corrosion Avoid touching or contaminating the bare electrode surface as dirt can increase calibration times Use of corrosive chemicals will damage the electrodes Conditioning To minimize DC offset and drift place the electrodes in the working position 5 minutes before starting the measurement The electrodes need some time to achieve electrochemical equilibrium with the skin and electrolyte in the human body Cleaning Silver silver chloride Ag AgCl electrodes if wet will corrode This corrosion process will in the long run make the electrodes noisier It is important to clean and dry the electrodes immediately after use Wipe the electrodes clean with distilled water and dry the electrodes will a soft paper towel Never use solvents e g acetone acids or alkaline or soap water to clean the electrodes Sterilization When sterilization is required only gas or liquid agents should be employed Disinfectants containing mercury phenols bromine iodine zinc tin and organo metallic compounds should be avoi
7. 80 0 0 uum re ai CEG notes Fig 16 a Text box for post EEG notes enobio Please include some post EEG noun Fig 16 b Entering text into the text box the ok button appears 20 Date of vee OOSREYTTY BLW Post LEG notes Please inctade some post EEG notes m b ne ep mady erpecksent a presented Fig 17 Click ok once you enter text into text box ste of vak DIAM AAA TET Fig 18 Output file generation notification 21 ry 3 gelidis Words 1318 GS Engish A sa Ente Faas Li ends Comat A Protoclfrcamjing C Dpto Fig 19 a Launch dropbox by doubleclicking dropbox icon B Help 4 irch Folders BB Folder Sync mcfernandez My Documents Dropbox v G Familia Fernandes 6 amp 8 FHR FM data FM outputs pei FoetoH as INTERGROWTH Y Y Interbio placement Fangfang Li Neurodevelopment FHR full data EEG DATA NAGPUR Intergrowth apps Intergrowth 1 NeuroAPP all sites NEW Neurodevelopment UK Photos Public Raw Data MR Systematic literature Sleep software 3 review_Xiao EORUEREREEE Eee Fig 19 b Access dropbox folder EEG DATA NAGPR by doubleclicking Bau m0 Oran i 22 EEG DATA NAGPUR 1 dropbox DROPBOX File 1 KB 9 Make a new folder 1 Publish this Folder to the Web EEG software E Share this Folder Fig 19 c Access folder called EEG da
8. INTERGROWTH 21 International Fetal and Newborn Growth Standards for the 21 Century The International Fetal and Newborn Growth Consortium CORTICAL AUDITORY ERP MANUAL December 2013 Cas UNIVERSITY OF Cam ry Hag 3 OXFORD Please read this manual carefully and refer to it throughout the study if any clarification is needed This Operations Manual was produced by the INTERGROWTH 21 Infant Development Group based on the 1 Meeting of the Group Oxford March 2012 This document reflects the consensus reached by members of the group regarding the selection of tests to be included in the INTERGROWTH 21 Neurodevelopment Package to be implemented by all centers taking part in the INTERGROWTH 21 follow up study INTERGROWTH 21 is a large project involving health institutions from eight geographically diverse countries It is therefore essential that all participating institutions follow a standardized neurodevelopment protocol Table of Contents CROCS O EA ea e WT E 4 SOUCO dt AR A AAA A A AA AA A a 5 SA TC 6 Testing procedure n eee Se eea aM 7 ApparatUS ear E 7 Methods ae easan eR A pv ai esd 7 Auditory Novelty Paradig cccccsccccccscsssessssecececssessesseaeeeeecesseesaeaeeeeecesseseeaeseeeessessesaaaeeeeeesseesees 9 ASES A A VI dete E 9 Experimental Protocol 5 teet ete bete ee a A ae aiii 10 Maintenance undc nir E RII EA ieee 26 Safety and Regulatory INfOrMatiOn ccccccccccec
9. al operation Fig 23 Technical specifications label Wd 7 Velcro to attach device to cap 31 References Bamiou D E Musiek FE Luxon LM Aetiology and clinical presentations of auditory processing disorders a review Archives of Disease in Childhood 2001 85 5 361 5 Kihara M Hogan AM Newton CR Garrashi HH Neville BR de Haan M Auditory and visual novelty processing in normally developing Kenyan children Clinical Neurophysiology 2010 121 4 564 76 SL NB cited Available from Attias J Urbach D Gold S Shemesh Z Auditory event related potentials in chronic tinnitus patients with noise induced hearing loss Hearing Research 1993 71 1 2 106 13 Haenschel C Baldeweg T Croft RJ Whittington M Gruzelier J Gamma and beta frequency oscillations in response to novel auditory stimuli A comparison of human electroencephalogram EEG data with in vitro models Proceedings of the National Academy of Sciences 2000 97 13 7645 50 32
10. d vary V Leh massid Ba Right manteng an Faperment Fig 11 Entering the data of the child in the ERP tab This tells you h much of the battery is left ue 17 ERP PROTOCOL COPI TOL ul EL o0 uu wm wonm V Tha cl was part al a preterm follow ap mahy Analisa LEG recording time beloro experiment ls presented in vecon s Y Fertil Epia ete le pinos DI ce a appar aa Us OL a See barar ati elo len matsid Right mantoid Fig 12 Click start experiment enobio bran mo wcviess vint li uu M s sd T UA ila Ir VE m NU Lud FATA OH d Lea te N A il li AH Nia d i i Aid MN DR AN dune Wisi aM MM Fig 13 Go to EEG tab Make sure all eight channels blue circles are recording 18 enoblo GLS Humber 0000 Research code 1 Research code 2 A Date of birth OD UMATYYY Date of visit DIVA PAY Y Domi 1920 Tha child was part of tha preterm follow up tad Basalina LEG recording time beloro experiment la presented lin veconde UU Flearicel ground position Tarte ILI oe H 0 ORL ot fee paras etch ein AC B Right mastoid ERP PROTOCOL ME Elapsed and remaining time DA won Tha chid wes part od the preterm follew up vay Analisa LG recording ime belore experiment la pretended in seconds nd posan pe Vit Os OQ Sat Dwr we tod LI TCP Server Fig 15 Checking how much time has elapsed is remaining for the experiment 19 e
11. ded The electrodes and cable insulation will not withstand steam sterilization Darkening Silver chloride is light sensitive Exposure to light will darken the electrode surface This will not impair the electrode performance since the largest interstitial Ag AgCl matrix is not reached by light Storage Electrodes should be handled with care They must not be stored in contact with metals especially such active metals as iron or aluminium Also substances that could affect the electrochemical characteristics should be avoided Bare electrodes should be stored in a clean dry and dark container plastic or glass Malfunction If an electrode is not operating as specified and a noisy signal is experienced please follow the directions below concerning noisy electrodes Noisy electrodes A continuously noisy electrode generally means that it has reached its end of life The life of the electrode can be extended a little by using a grain 600 or higher waterproof abrasive paper to polish the electrode tip Use very soft circular movements preferably no more than 2 3 times on the same area removing an even very thin layer across the entire surface Life expectancy Ag AgCl sintered electrodes have a limited life span This is caused by several processes such as corrosion the dissolving of the chloride in the pellets and the wearing of the pellet during the cleaning process Eventually the colour of the pellets will change from grey brown silve
12. ild s hair rather than the child s skin it is important that these electrodes are in the right position on the child s mastoid and are in contact completely with the skin If you need to terminate the experiment prematurely click STOP EXPERIMENT Fig 14 If you do not terminate the experiment it will run for 10 minutes you can see how much time has elapsed and how much time is remaining on the software Fig 15 Once the experiment is over because 10 minutes are up or because you clicked STOP EXPERIMENT you will be presented with a text box Fig 16 a and b and asked to add POST EEG NOTES You will have to type something in this text box otherwise the software will not allow you to proceed with the upload Please include all comments such as the child was eating during the assessment the child was crying the mother was talking loudly and the room was noisy If the assessment was uneventful please write NONE or UNEVENTFUL in the box Once you type something in click OK Fig 17 Once you click OK in the text box an output file will be automatically generated and a pop up box will appear to tell you about this Fig 18 The zipped files will be saved in a specific folder location within the NIC program Copy the files from this folder Go to the dropbox folder called EEG Data Nagpur Inside this open the folder called EEG data gt Zipped files Create a folder called EEG ex
13. ime In order to prevent over discharging the battery should be charged periodically Over discharging may cause loss of cell performance or damage battery function 27 Safety and Regulatory Information Enobio is a class lla device according to the classification in the Council Directive 93 42 CEE for medical devices It conforms to the following Standards and Directives Directive 93 42 CEE for medical devices UNE EN 60601 1 1993 A1 1996 A2 1996 A3 1997 A2 ERR 1999 UNE EN 60601 1 2 2008 UNE EN 60601 1 26 2004 Manufacturer Neuroelectrics Barcelona SL C Teodor Roviralta 45 08022 Barcelona Spain Telephone 34 93 254 03 70 Brand Enobio Models Enobio 8 Channels Enobio 20 Channels Use environment The Enobio system has been designed for the use in a clinical environment hospital or research centre Safety Warnings 1 The results of the measurements must be analysed by a doctor or specialist 2 No self medication should be done based on these results 3 The device must never be opened or damaged 4 The battery can only be replaced by authorized personnel 5 Before using please check that the device is undamaged and the packaging has not been affected by the transport or storage 6 Before using the device please inform the prescribing clinician or operator of the presence of any pacemakers intracranial electrodes implanted defibrillators cranial pathologies e g holes plaques or any
14. lle de Haan Expert Advisor Reader in Developmental Cognitive Neuroscience Institute of Child Health University College London London UK Aureli Soria Frisch Technical amp Signal Processing Expert Neuroelectrics STARLAB Barcelona Spain David Ibanez Technical amp Signal Processing Expert Neuroelectrics STARLAB Barcelona Spain Javier Acedo Technical amp Signal Processing Expert Neuroelectrics STARLAB Barcelona Spain Guillem Mitja Technical Expert Neuroelectrics STARLAB Barcelona Spain Morten Kringelbach Expert Advisor Director of Hedonia Trygfonden Research Group Department of Psychiatry Warneford Hospital University of Oxford Oxford UK Source Auditory and visual novelty processing in normally developing Kenyan children Kihara M Hogan AM Newton CR Garrashi HH Neville BR de Haan M Clinical Neurophysiology 121 2010 564 576 Further information Dr Michelle Fernandes E michelle fernandes obs gyn ox ac uk T 44 0 1865222936 2012 INTERGROWTH 21 Project The Nuffield Department of Obstetrics amp 5Gynaecology The John Radcliffe Hospital Oxford OX3 9DU United Kingdom www intergrowth 21st org uk Introduction An estimate of the prevalence for auditory processing disorders APD in childhood is 7 Hearing impairment s arising from pathology of the brain may have detrimental consequences on a child s life if untreated however diagnostic and management strategies for
15. nsmitter base If it goes off please disconnect the transmitter cable from the headphone jack and reconnect it the green light will come on You must check this at 1 5 minutes into the recording before the sounds are presented as if the green light is not on the sounds will not be presented to the child b Software vi vii viii Xi xii xiii xiv XV xvi xvii xviii Put the NECBOX on Fig 5 Go to the desktop of the computer and launch the NIC software by double clicking on the icon Fig 6 Note Do not open the NIC software before putting the NECBOX on as the Bluetooth of the software will search for the NECBOX and if it does not find it the software will hang you will then have to shut down and restart the computer The NIC software will open Fig 7 Go to the settings tab Fig 8 In the settings tab select the NECBOX you are using Fig 9 Go to the ERP protocol tab Fig 10 Enter all the data of the child Fig 11 Please mention where you have placed the electrodes i e on the right or left mastoid Click start experiment Fig 12 Go to the EEG tab Fig 13 Make sure all 8 channels are recording If one or two channels are not recording press them so that they make contact with the child s scalp Then recheck whether all 8 channels are recording If the signals do not look correct please check the reference electrodes to make sure they have not fallen off or are stuck to the ch
16. pid to administer 15 minutes Of the tests of auditory processing considered the measurement of ERPs to auditory stimuli was found to meet the criteria mentioned above Measurement of ERPs to an auditory novelty paradigm was found to have a high degree of sensitivity in detecting subtle differences in auditory processing in children Audiometry was not found to be suitable for children less than 4 years of age The measurement of acoustic reflex thresholds and otoacoustic emissions assessed solely middle ear function and not the entire auditory pathway In addition these tests required a probe to be placed in the child s ear for up to 3 minutes This was found to pose considerable difficulties in compliance in the field The measurement of ERPs to auditory stimuli was selected to measure auditory processing in 2 year olds in the follow up study of the INTERGROWTH 21st Project This was selected because ERPs response to deviance and or novelty reflects the child s ability to detect and assimilate novel events and this has been found to be fundamental to cognitive development Technical issues related to the measurement of electroencephalography EEG in the field included Difficulties in obtaining consent from parents because of the presentation of the EEG and the child with electrodes Difficulties in eliciting co operation from children in sitting still and not becoming irritable during the recording Specialist training required for
17. pplies Please inform Michelle Fernandes if the stock of disposable electrodes is running low Please give her 6 weeks to pace the order and courier them to you Test Duration Details Set up 1 3 minutes Test duration 10 minutes Termination 1 minute Total duration 12 14 minutes Fig 3 Electrode placements Disposable electrodes attached to DRL and CMS Fig 4 Stick on electrodes to DRL and CMS cables On off switch Fig 5 NECBOX on yellow light comes on when you put it on Fig 6 Launching NIC software on desktop Fig 7 NIC software opening after double clicking icon 15 enobio Fig 8 Click on settings tab NE enobjo c P mn ul s Bluercoth a mmm IT ER This yellow bar tells Ka DAMN 1637000 you the Bluetooth is connected Signai Monkoring E A 2 Clapsed Tima Romaininy E Time B Fite r Select your device then click select Fig 9 Selecting the NECBOX you are using 16 Date of visit 0O UBUYYYY 10790 n Lag tmo betara experiment ls presented fe oper ind De ORI on Da ibm OI wind fight mastoid Fig 10 Go to ERP protocol tab CRP PROTOCOL umber 1000 Research code Date of birth OD IUATYYY Date of visit DDVMANYYYY nimi Tuto V tha chiM wes pari oj tho preterm folles vp saih salus CEG recording time beloro experiment ls preueried in petonds Y Hlectrkcal ground potitus IT 1 Of ce fs spa v 04 OAL an Pa ern vi
18. r chloride to silver due to the loss of the chloride The AgCl slowly dissolves in gel and water during the 26 cleaning Eventually this leaves only silver behind The resulting pure silver electrode has much higher drift and noise characteristics than the original Ag AgCl electrode At this point replacement is recommended Neoprene Cap and NECBOX cleaning and disinfecting instructions After each use the Neoprene Cap and NECBOX should be cleaned and disinfected The surfaces of the neoprene cap and NECBOX may be wiped clean using a disinfectant wipe and left to air dry Battery operating safety instructions Charging the battery The battery can only be charged when the power ON switch is at the OFF position To charge the battery the following specifications have to be met 5VDC 4 25 7 V 1A current output Power input 5W Battery charger complies according to standard IEC EN 60601 1 It has to be connected to the microUSB connector located at the rear part of the NECBOX Fig 11 Charging with a higher voltage than specified may cause damage to the cell The usual time to charge a battery from the cut off voltage to the maximum capacity is around 2 hours The expected life cycle is gt 500 cycles with gt 70 96 of initial capacity The battery state of charge is measured by the software while the device is powered ON It should be noted that the battery will be over discharged if the device is not used for a long t
19. setting up the electrodes and recording EEG signals Difficulties in preparation of the child s scalp using gel Difficulties in the placement of electrodes In order to meet these challenges we propose a novel wireless portable method of recording EEG signals the methodology for which is described below The acquisition occurs over the first 2 years of life predominantly between 18 and 24 months Their analysis of electrophysiological brain activity in relationship to auditory processing allows To build a profile of auditory processing thresholds including amplitudes and latencies of responses according to age ll To assess group and individual variability lll To assess the nature and pace of neurocognitive development in children Testing procedure Apparatus EEG signals will be measured using a portable wireless EEG recording system called the Enobio Fig 1 The Enobio is an 8 channel EEG system with a bandwidth range of 0 to 125 Hz and a sampling range of 500 SPS EEG signals are measured using dry gel free electrodes and the signals are transmitted wirelessly to a processor All EEG data is stored on the Enobio software and a preliminary analysis is performed instantly In addition the Enobio allows for signals to be uploaded to a cloud providing real time access of data The Enobio is being customized for use in the follow up of the INTERGROWTH 21st Project by incorporating wireless headphones in to
20. sssessssecececessesecssaeeeeeceseeseaeseeeescesseseaaeaeeeeseessessaaeaeeeesens 28 Use environmerit neret ertet ot n e eB n RE REO 28 eric ER 28 Conditions OF use ences cess ertet c traiectus de et etie ede testa ae ind 29 Technical Specification Ssn o tenet t etis edite els ete eae eta eda o edu 29 Product Description see vt tete ee tret esie e veste o eeu 29 References decani nena iu ae Ine 32 Credits This manual was prepared by members of the INTERGROWTH 21st Infant Development Group and reflects the general consensus reached during the Infant Development Group Meeting Oxford 23 March 2012 regarding the selection of tests to be included in the INTERGROWTH 21 Neurodevelopment Package The following people made important contributions to this final version for which we thank them Michelle Fernandes Group Coordinator Nuffield Department of Obstetrics and Gynaecology the John Radcliffe Hospital University of Oxford Oxford UK Alan Stein Senior Advisor Section of Child and Adolescent Psychiatry Department of Psychiatry Warneford Hospital University of Oxford Oxford UK Charles Newton Senior Advisor Department of Psychiatry Warneford Hospital University of Oxford Oxford UK and Senior Clinical Research Fellow KEMRI Wellcome Trust Research Programme Kilifi Kenya Michael Kihara Expert Advisor Associate Professor Department of Psychology United States International University Nairobi Kenya Miche
21. ta B EEG DATA D Make a new Folder 3 Publish this folder to the Web Size 59 MB Folders EEG EXTRACTED FILES 5 14Aug13 Files EJ Share this folder Fig 19 d Access folder called zipped files by double clicking 23 G Zipped files File Edit View Favorites Tools Help Q JO search gt Folders Fl Address S Folder Sync O C Documents and Settings mcfernandez My Documents Dropbox EEG DATA NAGPUR EEG DATA Zipped files File and Folder Tasks E 20130713080536 ERP 04 33 9 237 KB Make a new folder 2 this folder to the 20130713114012 ERP 04 33 6 327 KB EZ Share this folder 20130724110520 ERP 04 33 Other Places Y 11 851 KB Details Y 20130710131608 ERP 04 33 9 311 KB d 20130709082954 ERP 04 33 9 937 KB 20130720121953 ERP 04 33 9 892 KB 20130710092831 ERP 04 33 12 264 KB EEG EXTRACTED FILES AA 20130713100258 ERP 04 33 7 818 KB 20130724111953 ERP 04 33 8 761 KB 20130710115311 ERP 04 33 11 279 KB 20130710085327 ERP 04 33 0 B 20130710085327_ERP 04 3363 23 24 2011072 Type Compressed zipped Folder Date Modified 10 07 2013 04 34 Size 10 1 MB 201307200655 10 608 KB 20130709073908_ERP 04 33 9 805 KB 20130717080228_ERP 04 33 12 292 KB Fig 19 e Create a folder called EEG extracted files dd mm yy add the date Paste the zipped files into
22. tracted files dd mm yy add the date Paste the zipped files into this folder Please paste ONLY the zip files and not the info files Fig 19 Close the software Fig 20 xix Put the NECBOX off 3 Post experiment tasks a Take off the reference electrodes from the child s skin with care Turn the NECBOX off and remove it from the cap Take the cap off the child s head Turn the headphones off on the cap Red light must go off Disconnect the cables carefully Disentangle any tangled cables and stored the papp cables carefully in the black box Remove the front and back ends of the electrodes and store them in the black box Th g Place the cap in the black box Other points to note Cleaning of electrodes and cap 1 Clean and dry the electrodes immediately after assessment by i Wiping with a clean paper towel dipped in distilled water ii Drying immediately with a soft paper towel 2 Wipe cap amp cover clean using disinfectant wipe 3 The electrodes are very delicate they corrode in contact with metal air water light and solvents They are also very expensive Ensure that they are stored in their own envelope and placed in the black box Charging equipment 1 Charge the NECBOX via the microUSB connector located at the rear part of the NECBOX when the battery falls below 5096 You can check the battery strength on the software 2 Charge the headphones via the transmitter once in 4 assessments Su
23. velty paradigm is presented The EEG data will be recorded at a sampling rate of 500 Hz with a system band pass between 0 and 100 Hz Fig 1 The Enobio wireless EEG monitoring system Lt posterior view Rt lateral view Fig 2 schematic representation of electrode placement on the Enobio for the assessment of auditory processing Auditory Novelty Paradigm The auditory paradigm is composed of 3 types of sounds presented through the wireless headphones attached to the Enobio 10 of these sounds are infrequent tones 2kHz 200 ms long 5 ms rise and fall time and 70 dB SPL 10 are novel noises such as a dog bark bell ring drum roll etc while the remaining 80 are frequent sinusoidal tones 1 5 kHz 200 ms long 5 ms rise and fall time 70 dB SPL Two blocks of 700 stimuli each were presented 560 frequent 70 infrequent and 70 novels There were 14 different novel stimuli and these were repeated no more than 5 times each during the course of the experiment The total duration of the stimuli presentation is 11 minutes Assessment Kit The assessment kit consists of 1 The Enobio i e the neuroelectrics control box NECBOX 10 wire cables with back ends electrode font ends battery charger NE headband NE cap USB connector 2 Alaptop containing the Enobio software 3 Acomputer laptop or desktop a television or a portable DVD player on which the silent cartoons can be viewed 4 Acomfortable chair for the mother
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