neonatal manual for standard newborn care
Contents
1. 16 17 Do not touch the device while EEG monitoring is on Always unplug the USB power supply from the device prior connecting electrodes to the subject The device will not work when charging the battery Never use the device or install the electrodes on the head of the patient while connected to the power network The device must be used only with Ag AgCl electrodes recommended by the manufacturer The device is not protected against other high freguency devices To avoid risks place the CMR DRL as far as possible from the s and return electrode of the high frequency device The device is wireless and might be affected by other RF devices The device needs special EMC precautions It needs to be used according to user manual information regarding EMC The EMC emissions and immunity has been tested using the 10 wires or 12 wires 34 cm cables provided with the system The use of other cables or electrodes than the ones delivered with the product might produce higher EMC emissions and less EMC immunity The device cannot be beside used or piled under other eguipment If such usage is needed check the normal configuration The device can only be used in healthy skin without wounds Conditions of use Enobio must be used in normal temperature and pressure conditions T range 10 45 C humidity 20 9096 atmospheric pressure 700 1000 hPa Technical Specifications EEG functionality Number of Channels 8 or 20 Channels2. Associate Professor Department of Psychology United States International University Nairobi Kenya Michelle de Haan Expert Advisor Reader in Developmental Cognitive Neuroscience Institute of Child Health University College London London UK Aureli Soria Frisch Technical amp Signal Processing Expert Neuroelectrics STARLAB Barcelona Spain David Ibanez Technical amp Signal Processing Expert Neuroelectrics STARLAB Barcelona Spain Javier Acedo Technical amp Signal Processing Expert Neuroelectrics STARLAB Barcelona Spain Guillem Mitja Technical Expert Neuroelectrics STARLAB Barcelona Spain Morten Kringelbach Expert Advisor Director of Hedonia Trygfonden Research Group Department of Psychiatry Warneford Hospital University of Oxford Oxford UK Source Kihara M Hogan AM Newton CR Garrashi HH Neville BR de Haan M Auditory and visual novelty processing in normally developing Kenyan children Clinical Neurophysiology 2010 121 564 576 Further information Dr Michelle Fernandes E michelle fernandes obs gyn ox ac uk T 44 0 1865222936 2012 INTERGROWTH 21 Project The Nuffield Department of Obstetrics amp 5Gynaecology The John Radcliffe Hospital Oxford OX3 9DU United Kingdom www intergrowth 21st org uk Introduction An estimate of the prevalence for auditory processing disorders APD in childhood is 7 Hearing impairment s arising from pathology of th
3. Bandwidth O to 125 Hz Sampling rate 500 SPS Resolution 24 bits 0 05 microVolt Measurement Noise lt 1 uV RMS Input impedance 1000 Mohm minimum Allows for Stimulation simultaneously Other Technical Specifications Communication Bluetooth 2 1 Output EDF ASCII data files or tcp ip raw data streaming 3 axes accelerometer MicroSD card for off line storage 28 Operating time 8 hours for EEG only Dimensions 60 x 85 x 20 mm Weight 65 g Compatible with Windows 7 Windows Vista Windows XP MAC OS X Product Description See Figure 19 to 21 below for product description 1 USB connector for charging battery Must not be on when EEG recording is in progress EE a bc 2 Power ON switch O indicates OFF position and allows for charging of the battery I indicated ON position no charging possible Figure 19 NECBOX USB connector and power switch 4 12 EEG connector and reference signals 5 8 EEG connector and reference signals 3 MicroSD card socket Figure 20 NECBOX EEG connector reference signals and MicroSD card socket 29 8 Technical specifications label 6 LED indicates normal operation f T NE 7 Velcro to attach device to cap Figure 21 LED light label and velcro support 30 References Bamiou D E Musiek FE Luxon LM Aetiology and clinical presentations of auditory processing disorders a review Ar
4. eliciting co operation from children in sitting still and not becoming irritable during the recording Specialist training required for setting up the electrodes and recording EEG signals Difficulties in preparation of the child s scalp using gel Difficulties in the placement of electrodes In order to meet these challenges we propose a novel wireless portable method of recording EEG signals the methodology for which is described below The acquisition occurs over the first 2 years of life predominantly between 18 and 24 months Their analysis of electrophysiological brain activity in relationship to auditory processing allows To build a profile of auditory processing thresholds including amplitudes and latencies of responses according to age ll To assess group and individual variability lll To assess the nature and pace of neurocognitive development in children Testing procedure Apparatus EEG signals will be measured using a portable wireless EEG recording system called the Enobio Figure 1 The Enobio is an 8 channel EEG system with a bandwidth range of 0 to 125 Hz and a sampling range of 500 SPS EEG signals are measured using dry gel free electrodes and the signals are transmitted wirelessly to a processor All EEG data is stored on the Enobio software and a preliminary analysis is performed instantly In addition the Enobio allows for signals to be uploaded to a cloud providing real time access
5. of data The Enobio is being customized for use in the follow up of the INTERGROWTH 21 Project by incorporating wireless headphones in to the neoprene cap and the auditory novelty program into its software to automate the presentation and recording of the same Methods Each child will be seated either on a chair or on his her mother s lap in a partially lit guiet room facing a computer monitor approximately 50 cm away The Enobio cap containing 8 electrodes will be placed over the child s head and a reference electrode will be clipped to the mastoid region of the Enobio cap The Enobio was customized for the purpose of this study to a fit the cranial dimensions of a two year old child and b integrate wireless headphones into the cap The Enobio cap will contain dry EEG placed at sites Fz Cz Pz T3 T4 T5 and T6 according to the international 10 20 system of electrode placement Figure 2 Eye movements and blinks will be monitored by the Fp2 electrooculogram electrode also integrated into the Enobio cap The child will be asked to watch a series of cartoon video clips on the computer screen The cartoons will have their audio clips removed and instead of the cartoon s audio the experimental auditory stimuli will be presented to the child via the wireless earphones The presentation of these stimuli and the recording digitization and processing of the EEG data will be carried out automatically with the Enobio software If the ch
6. of the stimuli presentation is 11 minutes Experimental Protocol Assessment Kit The assessment kit consists of 1 The Enobio i e the Neuroelectrics Control Box NECBOX 10 wire cables with back ends electrode font ends battery charger NE headband NE cap USB connector 2 Alaptop containing the Enobio software 3 A computer laptop or desktop a television or a portable DVD player on which the silent cartoons can be viewed A colouring book and crayons in case the child doesn t want to watch the cartoons 4 A comfortable chair for the mother and child Set Up and Method of Assessment 1 Pre experiment tasks a Ensure battery of NECBOX is charged b Install front ends and back ends into cap according to pre defined format in the table below Figure 3 Back end number Position Fp2 Fz Cz Pz T4 T6 T3 T5 0 Y dll BWN c Attach stick on electrodes to DRL and CMS cables Figure 4 d Ensure headphones and antenna are fixed on channel 1 e Ensure the antenna transmitter is connected to the computer through the headphone jack f Ensure computer volume is set on level 1 or 30 g Ensure the computer is connected to the internet either via a broadband cable or Wifi 2 Experiment a Cap Place the cap on the child s head Attach the 2 reference electrodes to the child s mastoid by peeling off the back sticker Both electrodes should be on the same mastoid so both on right or both on the
7. 3 11 279 KB 20130710085327_ERP 04 33 10 B 201307 10085327 _ERP 04 3363 23 24 2011072 Type Compressed zipped Folder Date Modified 10 07 2013 04 34 Size 10 1 MB 20130709073908_ERP 04 33 JS KB WWENWW 20130717080228_ERP 04 33 12 292 KB Figure 17 e Create a folder called EEG extracted files dd mm yy add the date Paste the zipped files into this folder Please paste ONLY the zip files and not the info files NIC 1 2 mE ERP PROTOCOL FGLS Number 00 0000 Research code 1 28 Research code 2 28 Date of birth DD MM YYYY 18 06 2012 Date of visit DD MM YYYY 18 06 2014 mi The child was part of the preterm follow up study Baseline EEG recording time before experiment is presented in seconds 120 Electrical ground position remember to place CMS on the upper and the DRL on the lower stick electrode ul Left mastoid Start Experiment Right mastoid Annotations Clear Form Upload to ftp Portable wireless brain monitoring system 11 37 25 Bluetooth Battery 88 Signal Monitoring gt ON 00 00 00 00 00 00 C UsersiIntergrowth21 stDocuments NIC 2014 0618113635_ERP 00 0 START TCP Server 10 28 251 55 1234 Figure 18 Close the software 24 Maintenance Silver Silver Chloride Ag AgCl electrode instructions Precautions for handling electrodes Electrodes should not come into direct contact with metals as t
8. INTERGROWTH 21 International Fetal and Newborn Growth Standards for the 21 Century The International Fetal and Newborn Growth Consortium CORTICAL AUDITORY ERP MANUAL June 2014 December 2013 aa UNIVERSITY OF OXFORD Please read this manual carefully and refer to it throughout the study if any clarification is needed This Operations Manual was produced by the INTERGROWTH 21 Infant Development Group based on the 1 Meeting of the Group Oxford March 2012 This document reflects the consensus reached by members of the group regarding the selection of tests to be included in the INTERGROWTH 21 Neurodevelopment Package to be implemented by all centers taking part in the INTERGROWTH 21 follow up study INTERGROWTH 21 is a large project involving health institutions from eight geographically diverse countries It is therefore essential that all participating institutions follow a standardized neurodevelopment protocol Table of Contents A DN DD DF DIO rii 4 SOU SE HR NON FR Y RI O EN A AG NG ia 5 IntrodUctiOn send Yd yy ded Fad ynde Yd ged des ddd da 6 TestingiprocedurT6 amp u ul WR Lu ydeu TYGWYN A EE 7 APparatUS ee Rd Yd dd A Y Yd ir ld ddf 7 Methods eu eu dn GYT td NYFODOL Y NR E A ATO Fw 7 Auditory Novelty P rdi Moesiei Sd DDd deka Aa a a e AA AR USB 9 Experimental Protocol acta ceria di A Y Cd A Md AO 10 ASSESSMENT rica do A A ta ead stan Rd A I DAU 10 Set Up and Method of ASSCSSMENL cc cccccc
9. Number 00 0000 Research code 1 28 Research code 2 28 Date of birth DD MM YYYY 18 06 2012 18 06 2014 ol The child was part of the preterm follow up study Baseline EEG recording time before experiment is presented in seconds 120 Electrical ground position remember to place CMS on the upper and the DRL on the lower stick electrode Annotations Clear Form Upload to ftp EEG SETUP Reference Channel None Time Domain 2 o 7 7 a a ie zs gt Voltage uV Visualization Filters O oo ooo TERR ml Date of visit DD MMIYYYY Figure 10 Click start experiment NIC 1 2 Temporal Window 5 Seconds Time Seconds 3 0Hz 9100110 Portable wireless brain monitoring system Bluetooth Battery Signal Monitoring ON 00 00 00 Record 00 00 00 Patient01 START TCP Server 10 28 251 55 1234 ss g 11 29 00 Bluetooth Battery 93 Signal Monitoring gt ON gt 00 00 34 Record 00 09 25 C JUsersiIntergrowth21 st Documents NIC 2014 0618112826_ERP 00 0 STOP TCP Server 10 28 251 55 1234 DELTA THETA ALPHA BETA GAMMA DEFAULT Figure 11 Go to EEG tab Make sure all eight channels blue circles are recording 18 3 Portable wireless ERP PROTOCOL eno 10 brain monitoring system FGLS Number Bluetooth a 00 0000 Research co
10. as elapsed is remaining for the experiment FGLS Number 00 0000 Research code 1 28 Research code 2 28 Date of birth DD MM YYYY 18 06 2012 Ll The child was part of the preterm follow up study NIC 1 2 ERP PROTOCOL Date of visit DD MM YYYY Post EEG notes 18 06 2014 Please include some post EEG notes Baseline EEG recording time before experiment is presented in seconds 120 Electrical ground position remember to place E Start Experiment eft mastoid Annotations Clear Form FGLS Number 00 0000 Research code 1 28 Research code 2 28 Date of birth DD MM YYYY 18 06 2012 E The child was part of the preterm follow up study S on the upper and the DRL on the lower stick electrode Right mastoid Upload to ftp Figure 14 a Text box for post EEG notes NIC 1 2 ERP PROTOCOL Date of visit DD MM 18 06 2014 Post EEG notes Please include some post EEG notes The child was crying and pulled off the cap at 00 20 Baseline EEG recording time before experiment is presented in seconds 120 Electrical ground position remember to plac Ll Left mastoid Start Experiment Annotations Clear Form CMS on the upper and the DRL on the lower stick electrode Right mastoid Upload to ftp BEE Portable wireless brain monitoring ystem 2700 010 Bluetooth Battery 91 Signal Monitoring ON 00 01 48 00 08 11 C UsersiIntergrow
11. cal devices UNE EN 60601 1 1993 A1 1996 A2 1996 A3 1997 A2 ERR 1999 UNE EN 60601 1 2 2008 UNE EN 60601 1 26 2004 Manufacturer Neuroelectrics Barcelona SL C Teodor Roviralta 45 08022 Barcelona Spain Telephone 34 93 254 03 70 Brand Enobio Models Enobio 8 Channels Enobio 20 Channels Use environment The Enobio system has been designed for the use in a clinical environment hospital or research centre Safety Warnings 1 The results of the measurements must be analysed by a doctor or specialist 2 No self medication should be done based on these results 3 The device must never be opened or damaged 4 The battery can only be replaced by authorized personnel 5 Before using please check that the device is undamaged and the packaging has not been affected by the transport or storage 6 Before using the device please inform the prescribing clinician or operator of the presence of any pacemakers intracranial electrodes implanted defibrillators cranial pathologies e g holes plaques or any other prosthesis The use of the device could result in these cases unsafe 7 Inthe case of malfunction immediately contact the manufacturer or the distributor 8 The device is not protected against excessive moisture or immersion in liquid In the case of the device becoming wet or damp do not use it and immediately contact the manufacturer 27 9 10 11 12 13 14 15
12. cesssssssssecececessessaeeeeececessesesaesesecesesseaeaeeeeeesseeseaeaeeeeeens 10 Maintenance nenn oridi aE oaa dA E aA a E e O i a o iA LOT OG adwy do 25 Safety and Regulatory InformatioN cccccconoooononnnnnnnnononononnnnnnnnononanononnnnnnnnnnnnnnonnnnnnnnnnnnnnnnns 27 Use environment Iys nidad dede 27 Safety Warnings siscveticke ts tt A A efyn YG e 27 Conditions ofUse AAA A AA NG Y adie 28 Technical SpecificationSs aaa 28 Product Description ne i Bn gd AN GY Y NY WN 29 Rd ee ee ee e e e e YN 31 Credits This manual was prepared by members of the INTERGROWTH 21 Infant Development Group and reflects the general consensus reached during the Infant Development Group Meeting Oxford 23 March 2012 regarding the selection of tests to be included in the INTERGROWTH 21 Neurodevelopment Package The following people made important contributions to this final version for which we thank them Michelle Fernandes Group Coordinator Nuffield Department of Obstetrics and Gynaecology the John Radcliffe Hospital University of Oxford Oxford UK Alan Stein Senior Advisor Section of Child and Adolescent Psychiatry Department of Psychiatry Warneford Hospital University of Oxford Oxford UK Charles Newton Senior Advisor Department of Psychiatry Warneford Hospital University of Oxford Oxford UK and Senior Clinical Research Fellow KEMRI Wellcome Trust Research Programme Kilifi Kenya Michael Kihara Expert Advisor
13. chives of Disease in Childhood 2001 85 5 361 5 Kihara M Hogan AM Newton CR Garrashi HH Neville BR de Haan M Auditory and visual novelty processing in normally developing Kenyan children Clinical Neurophysiology 2010 121 4 564 76 Neuroelectrics Enobio Available at http www neuroelectrics com enobio Accessibility verified June 18 2014 Attias J Urbach D Gold S Shemesh Z Auditory event related potentials in chronic tinnitus patients with noise induced hearing loss Hearing Research 1993 71 1 2 106 13 Haenschel C Baldeweg T Croft RJ Whittington M Gruzelier J Gamma and beta frequency oscillations in response to novel auditory stimuli A comparison of human electroencephalogram EEG data with in vitro models Proceedings of the National Academy of Sciences 2000 97 13 7645 50 31
14. de 1 28 87 Research code 2 28 Signal Monitoring Date of birth DD MM YYYY Date of visit DD MM YYYY 18 06 2012 18 06 2014 11 32 57 Battery ON Record Baseline EEG recording time before experiment is presented 00 00 13 in seconds 00 09 46 C Users lntergrowth21 Electrical ground position st Documents NIC 2014 iber to place CMS on the upi d the DRL on the lower stick electrode remember to place CMS on the upper and the DRL on the lower stick electrode 0618113244 ERP 00 0 v 120 TOP Stop Experiment Recording EEG baseline AI TCP Server Annotations 10 28 251 55 1234 Figure 12 Click STOP experiment to terminate experiment prematurely u Portable wireless ERP PROTOCOL QT 10 110 brain monitorin yin 11 32 57 FGLS Number Bluetooth a 00 0000 Research code 1 28 87 Research code 2 28 Signal Monitoring Gap Battery Date of birth DD MM YYYY Date of visit DD MM YYYY Elapsed and remaining time 18 06 2012 18 06 2014 ON Record Baseline EEG recording time before experiment is presented 00 00 13 in seconds 120 00 09 46 Electrical ground position C Users Intergrowth21 remember to place CMS on the upper and the DRL on the lower stick electrode AR WA TOP Stop Experiment Recording EEG baseline SIO TCP Server Annotations 10 28 251 55 1234 Figure 13 Checking how much time h
15. ditory processing between individuals Be easy to administer without specialist training Be internationally valid Be rapid to administer lt 15 minutes Of the tests of auditory processing considered the measurement of ERPs to auditory stimuli was found to meet the criteria mentioned above Measurement of ERPs to an auditory novelty paradigm was found to have a high degree of sensitivity in detecting subtle differences in auditory processing in children Audiometry was not found to be suitable for children less than 4 years of age The measurement of acoustic reflex thresholds and otoacoustic emissions assessed solely middle ear function and not the entire auditory pathway In addition these tests required a probe to be placed in the child s ear for up to 3 minutes This was found to pose considerable difficulties in compliance in the field The measurement of ERPs to auditory stimuli was selected to measure auditory processing in 2 year olds in the follow up study of the INTERGROWTH 21 Project This was selected because ERPs response to deviance and or novelty reflects the child s ability to detect and assimilate novel events and this has been found to be fundamental to cognitive development Technical issues related to the measurement of electroencephalography EEG in the field included Difficulties in obtaining consent from parents because of the presentation of the EEG and the child with electrodes Difficulties in
16. e brain may have detrimental conseguences on a child s life if untreated however diagnostic and management strategies for these central hearing impairments in childhood are rarely implemented These auditory deficits have been collectively termed auditory processing disorders in order to incorporate in the term the interaction between peripheral and central pathways Disturbances in auditory processing are an important indicator of disturbances in sensory neurodevelopment in children and measurement of a child s ability to detect and assimilate novel auditory stimuli may be used to examine subtle differences in auditory processing In addition higher prevalence of auditory processing disorders are reported in preterm babies children with a family history of deafness intra uterine infections and epilepsy A number of tests to assess auditory function in children were considered These included the use of audiometry acoustic reflex thresholds otoacoustic emissions communication inventories and the measurement of evoked response potentials ERPs to auditory stimuli It was decided that for use in the follow up study of the INTERGROWTH 21st Project the test of auditory assessment should Be suitable for use on children at 24 months of age Assess the entire auditory pathway and not just elements of the same Yield information about an auditory threshold amplitude and latency of responses Assess subtle changes in au
17. e metals as iron or aluminium Also substances that could affect the electrochemical characteristics should be avoided Bare electrodes should be stored in a clean dry and dark container plastic or glass Malfunction If an electrode is not operating as specified and a noisy signal is experienced please follow the directions below concerning noisy electrodes Noisy electrodes A continuously noisy electrode generally means that it has reached its end of life The life of the electrode can be extended a little by using a grain 600 or higher waterproof abrasive 25 paper to polish the electrode tip Use very soft circular movements preferably no more than 2 3 times on the same area removing an even very thin layer across the entire surface Life expectancy Ag AgCl sintered electrodes have a limited life span This is caused by several processes such as corrosion the dissolving of the chloride in the pellets and the wearing of the pellet during the cleaning process Eventually the colour of the pellets will change from grey brown silver chloride to silver due to the loss of the chloride The AgCl slowly dissolves in gel and water during the cleaning Eventually this leaves only silver behind The resulting pure silver electrode has much higher drift and noise characteristics than the original Ag AgCl electrode At this point replacement is recommended Neoprene Cap and NECBOX cleaning and disinfecting instructions After each use t
18. er towel dipped in distilled water ii Drying immediately with a soft paper towel 2 Wipe cap and cover clean using disinfectant wipe 3 The electrodes are very delicate they corrode in contact with metal air water light and solvents They are also very expensive Ensure that they are stored in their own envelope and placed in the black box Charging eguipment 1 Charge the NECBOX via the MicroUSB connector located at the rear part of the NECBOX when the battery falls below 5096 You can check the battery strength on the software 2 Charge the headphones via the transmitter once in 4 assessments Supplies Please inform Michelle Fernandes if the stock of disposable electrodes is running low Please give her 6 weeks to pace the order and courier them to you Test Duration Details Set up 1 3 minutes Test duration 10 minutes Termination lt 1 minute Total duration 12 14 minutes Enobio EEG placemen ts Disposable electrodes attached to DRL and CMS Figure 4 Stick on electrodes to DRL and CMS cables On off switch Figure 5 NECBOX on yellow light comes on when you put it on 15 a Mozila Firefox elm oe lmHRaew ns Ra wa Figure 6 Launching NIC software on desktop Trying to connect with device NE ENOBIOS 00 07 80 58 9C 28 Pa to al 0 e 3 18 06 2014 Figure 7 NIC software opening after double clicking icon 16 NIC 1 2 FGLS Number Research code 1 Re
19. he Neoprene Cap and NECBOX should be cleaned and disinfected The surfaces of the neoprene cap and NECBOX may be wiped clean using a disinfectant wipe and left to air dry Battery operating safety instructions Charging the battery The battery can only be charged when the power ON switch is at the OFF position To charge the battery the following specifications have to be met 5VDC 4 25 7 V 1 A current output Power input 5W Battery charger complies according to standard IEC EN 60601 1 It has to be connected to the microUSB connector located at the rear part of the NECBOX Fig 11 Charging with a higher voltage than specified may cause damage to the cell The usual time to charge a battery from the cut off voltage to the maximum capacity is around 2 hours The expected life cycle is gt 500 cycles with gt 70 of initial capacity The battery state of charge is measured by the software while the device is powered ON It should be noted that the battery will be over discharged if the device is not used for a long time In order to prevent over discharging the battery should be charged periodically Over discharging may cause loss of cell performance or damage battery function 26 Safety and Regulatory Information Enobio is a class lla device according to the classification in the Council Directive 93 42 CEE for medical devices It conforms to the following Standards and Directives Directive 93 42 CEE for medi
20. his may cause corrosion Avoid touching or contaminating the bare electrode surface as dirt can increase calibration times Use of corrosive chemicals will damage the electrodes Conditioning To minimize DC offset and drift place the electrodes in the working position 5 minutes before starting the measurement The electrodes need some time to achieve electrochemical eguilibrium with the skin and electrolyte in the human body Cleaning Silver silver chloride Ag AgCl electrodes if wet will corrode This corrosion process will in the long run make the electrodes noisier It is important to clean and dry the electrodes immediately after use Wipe the electrodes clean with distilled water and dry the electrodes will a soft paper towel Never use solvents e g acetone acids or alkaline or soap water to clean the electrodes Sterilization When sterilization is reguired only gas or liguid agents should be employed Disinfectants containing mercury phenols bromine iodine zinc tin and organo metallic compounds should be avoided The electrodes and cable insulation will not withstand steam sterilization Darkening Silver chloride is light sensitive Exposure to light will darken the electrode surface This will not impair the electrode performance since the largest interstitial Ag AgCl matrix is not reached by light Storage Electrodes should be handled with care They must not be stored in contact with metals especially such activ
21. ild prefers not to watch the video a colouring book and crayons will be provided Care will be taken to ensure noise levels are kept to a minimum in the room and the child mother will be encouraged to not speak loudly Electrical sources of sounds like ceiling fans will be switched off The Enobio s electrodes take 2 minutes to calibrate when placed on the child s head during which a baseline EEG is recorded for 2 minutes before the auditory novelty paradigm is presented The EEG data will be recorded at a sampling rate of 500 Hz with a system band pass between O and 100 Hz Figure 1 The Enobio wireless EEG monitoring system Lt posterior view Rt lateral view Figure 2 Schematic representation of electrode placement on the Enobio for the assessment of auditory processing Auditory Novelty Paradigm The auditory paradigm is composed of 3 types of sounds presented through the wireless headphones attached to the Enobio 1096 of these sounds are infreguent tones 2kHz 200 ms long 5 ms rise and fall time and 70 dB SPL 1096 are novel noises such as a dog bark bell ring drum roll etc while the remaining 8096 are freguent sinusoidal tones 1 5 kHz 200 ms long 5 ms rise and fall time 70 dB SPL Two blocks of 700 stimuli each were presented 560 freguent 70 infreguent and 70 novels There were 14 different novel stimuli and these were repeated no more than 5 times each during the course of the experiment The total duration
22. lder EEG DATA NAGPR by double clicking 22 2 EEG DATA NAGPUR 4 C Documents and SettingsimcfernandeziMy Documents Dropbox EEG DATA NAGPUR dropbox DROPBOX File 1 KB 9 Make a new Folder 3 Publish this Folder to the Web EEG software E Share this Folder Figure 17 c Access folder called EEG data m EEG DATA ADN Make a new folder Publish this folder to the Web Fager EEG EXTRACTED FILES 5 144ug13 Files EZ Share this Folder Figure 17 d Access folder called zipped files by double clicking 23 G Zipped files File Edit View Favorites Tools Help S El peck M z Y O Search Folders EEE l Folder Sync Address C Documents and Settings mcfernandez My Documents Dropbox EEG DATA NAGPURAEEG DATAZipped files File and Folder Tasks 2 a B Make a new Folder A Publish this Folder to the web EZ Share this Folder 7 KB EEFEE Other Places 11 851 KB Details 9 311 KB 9 937 KB a 2 KB 12 264 KB EEG EXTRACTED FILE 5 144uq13 20130713080536_ERP 04 33 20130713114012_ERP 04 33 20130724110520_ERP 04 33 20130710131608_ERP 04 33 20130709082954_ERP 04 33 20130720121953_ERP 04 33 20130710092831_ERP 04 33 20130713100258_ERP 04 33 7 KB 20130724111953_ERP 04 33 8 761 KB 20130710115311_ERP 04 3
23. left mastoid and they should ideally be as close together as possible Please paste the electrodes on the mastoid and not on the angle of the jaw or the neck Put the headphones on you will see a red light come on Double check that the transmitter is connected to the computer via the headphone jack of the computer you will see a green light on the transmitter base One and a half minute into the recording after you perform the steps below please recheck that the green light is still on on the transmitter base If it goes off please disconnect the transmitter cable from the headphone jack and reconnect it the green light will come on You must check this at 1 5 minutes into the recording before the sounds are presented as if the green light is not on the sounds will not be presented to the child b Software vi vii viii Put the NECBOX on Figure 5 Go to the desktop of the computer and launch the NIC software by double clicking on the icon Figure 6 Note Do not open the NIC software before putting the NECBOX on as the Bluetooth of the software will search for the NECBOX and if it does not find it the software will hang you will then have to shut down and restart the computer The NIC software will open Figure 7 Go to the ERP protocol tab Figure 8 Enter all the data of the child Figure 9 Please mention where you have placed the electrodes i e on the right or left mastoid Click Start Experimen
24. nd the room was noisy If the assessment was uneventful please write NONE or UNEVENTFUL in the box Once you type something in click OK Figure 15 Once you click OK in the text box an output file will be automatically generated and a pop up box will appear to tell you about this Figure 16 The zipped files will be saved in a specific folder location within the NIC program Copy the files from this folder Go to the dropbox folder called EEG Data Nagpur Inside this open the folder called EEG data gt Zipped files Create a folder called EEG extracted files dd mm yy add the date Paste the zipped files into this folder Please paste ONLY the zip files and not the info files Figure 17 a to e Close the software Figure 18 Put the NECBOX off 3 Post experiment tasks Dano Take off the reference electrodes from the child s skin with care Turn the NECBOX off and remove it from the cap Take the cap off the child s head Turn the headphones off on the cap Red light must go off Disconnect the cables carefully Disentangle any tangled cables and stored the cables carefully in the black box f Remove the front and back ends of the electrodes and store them in the black box g Place the cap in the black box Other points to note Cleaning of electrodes and cap 1 Clean and dry the electrodes immediately after assessment by i Wiping with a clean pap
25. s 120 Electrical ground position remember to plac LU eft mastoid Right mastoid S on the upper and the DRL on the lower stick electrode Start Experiment Annotations Clear Form Upload to ftp 218 0 0 8 Figure 16 Output file generation notification Portable wireless brain monitoring system Bluetooth gt 00 00 31 00 09 28 C Users Intergrowth21 stDocuments NIC 2014 0618113532_ERP 00 0 START TCP Server 10 28 251 55 1234 Portable wireless brain monitoring Bit 11 36 47 Bluetooth _ Battery 89 Signal Monitoring gt ON 00 00 00 00 00 00 CUsers ntergrowth21 stDocuments NIC 2014 0618113635_ERP 00 0 START TCP Server 10 28 251 55 1234 21 a HO 18 CIOSG the sartware Page 140115 Words 1318 gS Eng o Bes Asl Gil Fs Wl Feds Cty i rato for caring LJ Dpto Figure 17 a Launch dropbox by double clicking dropbox icon mr o U 0040198 00 O Help A rch a Folders i Folder Sync mcfernandez My Documents Dropbox had G 8 Familia Fernandes o82 FHR FM data pei FM outputs ei FoetoH A d INTERGROWTH sei Interbio placement Fangfang Li ei Neurodevelopment ei FHR full data ei EEG DATA NAGPUR cei Intergrowth 1 ei Intergrowth apps pI ICR sei NeuroAPP all sites NEW cei Neurodevelopment UK amp Photos po Public ei Raw Data MR e Sleep software ei Systematic literature review_Xiao Figure 17 b Access dropbox fo
26. search code 2 Date of birth DD MM YYYY Date of visit DD MM YYYY 18 06 2014 E The child was part of the preterm follow up study Baseline EEG recording time before experiment is presented in seconds 120 Electrical ground position remember to place CMS on the upper and the DRL on the lower stick electrode __ Left mastoid __ Right mastoid Annotations Clear Form Upload to ftp 3 Portable wireless enobjo Saas sinis 11 25 10 Bluetooth This yellow bar tells you Gn 7 Bluetooth is connected 90 This tells you how much A eTrrh gt of the battery is left ON Record co 00 00 00 00 00 00 Patient01 START TCP Server 10 28 251 55 1234 Figure 8 Go to ERP protocol tab NIC 1 2 FGLS Number 00 0000 Research code 1 28 Research code 2 28 Date of birth DD MM YYYY 18 06 2012 Date of visit DD MM YYYY 18 06 2014 ol The child was part of the preterm follow up study Baseline EEG recording time before experiment is presented in seconds 120 Electrical ground position remember to place CMS on the upper and the DRL on the lower ol Left mastoid Start Experiment Right mastoid Annotations Clear Form Upload to ftp BEE 11 27 29 Bluetooth Battery Signal Monitoring ON 00 00 00 00 00 00 Patient01 START TCP Server 10 28 251 55 1234 Figure 9 Entering the data of the child in the ERP tab 17 NIC 1 2 ERP PROTOCOL FGLS
27. t Figure 10 Go to the EEG tab Figure 11 Make sure all 8 channels are recording If one or two channels are not recording press them so that they make contact with the child s scalp Then recheck whether all 8 channels are recording If the signals do not look correct please check the reference electrodes to make sure they have not fallen off or are stuck to the child s hair rather than the child s skin it is important that these electrodes are in the right Xi xii xiii xiv XV xvi xvii position on the child s mastoid and are in contact completely with the skin If you need to terminate the experiment prematurely click STOP EXPERIMENT under the mastoid data entry tab Do not stop recording on the grey right hand column as this column is not related to the ERP experiment Figure 11 If you do not terminate the experiment it will run for 10 minutes you can see how much time has elapsed and how much time is remaining on the software Figure 13 Once the experiment is over because 10 minutes are up or because you clicked STOP EXPERIMENT you will be presented with a text box Figure 14 a and b and asked to add POST EEG NOTES You will have to type something in this text box otherwise the software will not allow you to proceed with the upload Please include all comments such as the child was eating during the assessment the child was crying the mother was talking loudly a
28. th21 stDocuments NIC 2014 0618112826_ERP 00 0 START TCP Server 10 28 251 55 1234 O Portable wireless brain monitoring system 2100 11 36 03 Bluetooth Battery 88 Signal Monitoring ON gt 00 00 31 Record 00 09 28 C UsersiIintergrowth21 stDocuments NIC 2014 0618113532_ERP 00 0 START TCP Server 10 28 251 55 1234 Figure 14 b Entering text into the text box the ok button appears 20 NIC 1 2 ERP PROTOCOL FGLS Number 00 0000 Research code 1 28 Research code 2 28 Date of birth DD MM YYYY Date of visit DD MM YYYY Post EEG notes 18 06 2012 18 06 2014 Please include some post EEG notes El The child was part of the preterm follow up study The child was crying and pulled off the cap at 00 20 Baseline EEG recording time before experiment is presented in seconds m Electrical ground position remember to place CMS on the upper and the DRL on the lower stick electrode El Left mastoid Right mastoid Start Experiment Annotations Clear Form Upload to ftp 9100110 Figure 15 Click ok once you enter text into text box NIC 1 2 ERP PROTOCOL FGLS Number 00 0000 Research code 1 28 Research code 2 28 Date of birth DD MM YYYY Date of visit DD MM YYYY 18 06 2012 18 06 2014 Output file generation Ll The child was part of the preterm follow up study Baseline EEG recording time before experiment is presented in second
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