A web-HUMAN Renal Physiology Experiment Response to
Contents
1. we now do this for all six of our selected variables in order to better understand our experimental design The 6 are AP EXNA PRA ECFV EXH20 and RENPP 3 Setting up the experimental intervention Inducing renal artery stenosis e Variables are changed in the Experimental Controls Change Variable section see below To induce a renal artery stenosis that drops renal perfusion pressure by 40 mmHg across its resistance mouse CLAMP in the Change Variable box and type in 40 in the Enter New Value box Do not enter units only the number Experiment Controls Change Variable Enter New Value Info on Variable CLAMP 40 Added mmHg 4 Executing the experiment e In the Run Experiment section of the navigator see below enter as shown 1 to run for 6d 2 at 12h intervals between data readouts and 3 then click the lt Go gt button Note that while HUMAN expects minutes as the default you can enter days and hours by appending d or h to your number Run Experiment for 6d minutes at 12h minute intervals Go Start Over 5 Your results appear as a graph and in the window under it as a table of numbers Note the enormous increase in plasma rennin activity PRA on the graph 6 We remove plasma rennin activity from our graph Since plasma rennin activity dominates the graphic result and thereby suppresses our visual resolution of the behavior of the other variables we remove it as follows e click the lt back arrow g2. HAPS 08 Workshop The web HUMAN Physiology Teaching Model http placid skidmore edu human A web HUMAN Renal Physiology Experiment Response to Renal Artery Stenosis Impaired renal perfusion initiates a complex humoral hemodynamic response that results in systemic hypertension 1 This impaired perfusion can be induced in HUMAN via the parameter CLAMP which represents the pressure drop across the stenosis in renal arteries Basic Procedure Always turn off your pop up blocker before working in web HUMAN 1 Selecting variables of interest to read out the behavior of e In the View Output section place each of the variables indicated in the first row below in your Tables AP EXNA PRA ECFV EXH20 RENPP View Output AP z EXNA X PRA ECFV EXH20 v RENPP as graph v graph graph graph graph graph e To graph each of these variables select the as graph option see above 2 Understanding the meaning of the variables selected using Help info on option e In the Help section under the Help info on Choose option see below mouse the variable of interest e g AP Help Help info on _ Choose a Haw Dao A2INE e A Variable Help window appears see below that explains the variable its units and other relevant information i 08 O Ohttp placid skid p i AP Mean Arterial Pressure i i This is a viewable variable 7 Units 100 0 mmHg a The central arterial blood pressure
3. t of your browser once to return to the screen on which you set this experiment up e uncheck the as graph option under PRA selecting as text instead see below PRA M e now simply re click lt Go gt again to rerun this time with PRA not graphing 7 We will discuss the graphic and tabular results Re table numbers note Scientific notation in FORTRAN and HUMAN scientific 1 0 10 1 0 1 in HUMAN 1 0 E 01 0 1 1 The above experiment draws heavily on Exp 6 Student s Manual HUMAN 80 Dr James E Randall 1981 available in the web HUMAN User s Manual Section VI Sample Models As always we thank Drs Randall amp Coleman for their generosity in making the HUMAN model amp associated materials available for non commercial educational uses
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