208258 GrandStand_UG_O:207382 GrandStand Uniflex UG
Contents
1. te oft 5 H a ee ATNO MORTA UV INDI ISN de t s F SMOWTE DNIMS ISA LON Oq 7 4 10045 4 lt rt axv MORTA UV INDY ISN ISA LON Od W SELON avds 2 5 2 TIVTNTHS 2 4 8 S8 SL ai NISSE WLS lt lt Bb 23 H t 3 i 4 i t i a B s 2 T 16 2 W ae z 2 a 8 5 vaas 0 36 O SE da OWS lt lt ss NWZSI dd WSW 9 9 WIS S dQ WSWSt dd OWS S S Sp dG ONS S User Manual 28 9555 2Y 20 Chapter 3 Photographic System Tour GrandStand system modular Front accessories A Data Acquisition Enclosure B Flow Meter requires A C Pressure Sensor requires A D Temperature Sensor requires A Conductivity Sensor requires UV Sensor requires G Permeate Pump H SIP Kit 4 Position HF Kit J Kvick Flow Cassette Kit replaces HF filters Fig 4 General arrangement of accessory options The GS550 is shown GS450 is similar except for 4 position option Permeate side tubing removed for simplicity User Manual 28 9335 29 AA 21 Data acquisition enclosure Facing the front of the GrandStand system side where motor and VFD are located mount the data acquisition enclosure to the horizontal frame using the threaded studs and2. Be sure that the permeate retentate lines are directed back to the CIP tank and secured Open the retentate valve 5 100 until all the air has escaped from the system then adjust to 20 open approximately 1 turn Push the FWD key on the AC Inverter Push the up arrow on the AC Inverter until the inlet pressure reaches approximately 8 psig 0 55 barg Adjust the pump speed retentate valve until Pi 10 psig 0 67 barg and Pou 6 psig 0 41 barg for microfiltration cartridges 15 psig 1 03 barg in and 11 psig 0 76 barg out for ultrafiltration cartridges NOTE The amount the retentate valve needs to be opened or how high the RPM needs to Pressure hold and integrity tests Before using the system check the filters cassette and holder or hollow fiber cartridges for proper installation Finally check the tightness of all sanitary clamps Users normally check their cross flow systems for leaks by pressurizing the system with water and observing any leakage from process connections Users also check the integrity of membrane filters before using them by pressurizing the system and measuring the diffusion of air through the filters If the diffusion rate meets acceptance criteria then the user is assured that the membrane filters do not contain pinholes and are securely mounted in the system GE Healthcare recommends that you complete air integrity tests on the system filters
3. 35 2 in series 28 0 71 1 3 0 7 6 1 5 3 8 1 5 3 8 X X X X X X 28 0 71 1 6 28 0 71 1 35SMO DP 29 4 74 7 3 6 9 1 1 5 3 8 1 5 3 8 0 5 X X X 29 4 74 7 6 29 4 74 7 2 in series 55 STM 29 6 75 2 3 6 9 1 1 5 3 8 1 5 3 8 0 5 0 5 29 6 75 2 6 29 6 75 2 45 2inseries 39 6 100 6 4 24 10 8 1 5 3 8 2 0 5 1 X X X X X X 39 6 100 6 39 6 100 6 35 STM 34 2 86 9 3 6 9 1 1 5 3 8 1 5 3 8 0 5 0 5 34 2 86 9 6 34 2 86 9 2 in series 45 MSM DP 41 6 105 7 4 5 11 4 1 5 3 8 2 0 5 1 0 5 X X X 41 6 105 7 41 6 105 7 2 in series 75 44 5 113 0 3 0 7 6 1 5 3 8 1 5 3 8 X X X X X X 44 5 113 0 6 44 5 113 0 85 51 5 130 8 4 25 10 8 1 5 3 8 2 0 5 1 X X X X X X 51 5 130 8 51 5 130 8 85 52 7 133 9 4 5 11 4 1 5 3 8 2 0 5 1 0 5 X X X 52 7 133 9 52 7 133 9 154m 54 8 139 2 6 63 16 8 1 5 3 8 2 0 5 1 X X X X X X 54 8 139 2 54 8 139 2 GrandStand 450 system housing and pipe spools dimensions continued Dimensions Not pipe spool Pipe spool Pipe spool Using both Center to center Angle housing required cm 6 5 13 5 in cm spools swing elbows cm 45 39 8 101 1 15 0 38 1 20 36 35 40 0 103 4 14 8 37 6 22 33 355 40 0 103 4 14 1 35 8 28 21 45 5 40 8 103 6 14 0 35 6 28 96 35 STM 43 1 109 5 11 7 29 7 43 01 65 42 3 107 4 12 5
4. Chapter 4 Using the Membrane System Introduction 29 Data aquisition operating system 29 Workflow 29 Chapter 5 System Preparation General 30 Checking pump oil 30 System installation 30 Stating the system 31 Cartridge installation 31 New cartridge rinsing procedures 1 Clean water flux determination 32 Pressure hold and integrity tests 32 Processing 33 User Manual 28 9335 29 AA 3 Chapter 6 System Cleaning and Storing Cleaning Short term storage Long term storage Storage conditions Chapter 7 Troubleshooting Troubleshooting guide Chapter 8 Maintenance Parts Inspection Maintenance General Cleaning before maintenance service Component maintenance Replacement of fuses Instrumentation calibration Voiding of warranty Disassembly and assembly Periodic maintenance Chapter 9 Service and Training Service Training Appendix 4 Membrane system label Membrane system warning labels Health and Safety Declaration Liability Form User Manual 28 9335 29 AA 34 34 34 34 55 36 36 36 36 36 36 36 37 37 37 37 38 38 39 39 39 Chapter 1 System Documentation and Safety About this user guide This user guide describes how to use GE Healthcare GrandStand membrane systems safely The systems described in this guide include GrandStand Modular systems models 450 and 550 Hereafter this user guide refers to these systems as the membrane system Audience This user guide addr
5. avoid equipment damage or bodily injury do not disconnect the system s hardware high pressure shut off system When the pressure exceeds the limit of the system the hordwore safety device will shut down the pumps and valves directly not via the control system Factory setting is 45 psig 3 06 barg Before restarting the system determine the cause of over pressurization This is usually a result of a flow restriction in the retentate line or an increase in the recirculation pump speed Make an appropriate adjustment in the system controls to avoid over pressurization Filter matrix spool combinations Use of a broad range of HF filters is enabled through a combination of swing elbows and piping spools See filter housing pipe spools table and HF filters piping spools drawing for elbow orientation and spool piece filter combination for the HF filter selected GrandStand 450 system specifications Base system GrandStand 450 Weight approximate Materials of Construction Frame Fluid path Fluid path surface finish Kvick Flow holder surface finish Front and back plate Feed retentate permeate ports CIP tank Pump Type Max Pump Flow rate O rings gaskets valve diaphragms System dead volume Power requirements 1576 Ibs 715 kg 304 stainless steel 316 L stainless steel lt 20 Ra in 0 5 Ra um lt 25 Ra yin 0 6 Ra um lt 20 Ra yin 0 5 Ra um 15 gal Polypropylene 56 7 L Rotary lo
6. when all components in the system have reached the normal working temperature range Special attention should be given to the parts that are marked as hot or cold with signs described in the appendix WARNING If you are exposed to excessively high noise levels bodily harm can result Check for warning signs in your work area and warning symbols on the membrane system indicating you need to wear hearing protection Wear hearing protection if required to avoid bodily harm WARNING If cabinet doors equipment covers and safety guards are not closed during operation equipment damage and bodily harm can result To prevent equipment damage and bodily harm properly close cabinet doors equipment covers and safety guards before starting the membrane system User Manual 28 9335 29 AA 7 2 System Description Introduction GE Healthcare manufactures standard GrandStand Modular systems Standard GrandStand systems include these Ordering information Code number Catalog number Description Base System 28 4005 31 GSMRLP550SYS 28 4005 32 GSMRLP450SYS 28 4004 48 GSMRLP550380V 28 4004 49 GSMRLP450380V 28 4004 53 GSMRLP550440V 28 4004 54 GSMRLP450440V GrandStand 550 Mod Sys 220VAC GrandStand 450 Mod Sys 220VAC GrandStand 550 Mod Sys 380VAC GrandStand 450 Mod Sys 380VAC GrandStand 550 Mod Sys 440VAC GrandStand 450 Mod Sys 440VAC Includes one set of documentation Additional sets of documents c
7. Clean water flux determination 32 Cleaning 34 Cleaning before maintenance 36 Component maintenance 36 Conductivity sensor 25 Contact addresses 2 Contact information 5 Customer support 5 D Data acquisition enclosure 22 Disassembly and assembly 37 Documentation 5 E Electrical system 8 Email address 5 Emergency stop 9 F Feed line pressure indicator 24 Filter matrix 9 Flow meter 23 Four position HF expansion kit 27 Fuse replacement 36 Fuses 8 H Hardware high pressure shut off 9 High pressure shut off 9 Health and safety declaration liability form 41 User Manual 28 9335 29 AA G GrandStand system specifications 9 GrandStand system 10 11 12 13 14 15 16 17 GrandStand system housing and pipe spools dimensions 18 19 GrandStand modular accessories 21 Inspection of system 36 Installation 30 Installing the system 30 K Kits SIP 27 Four position HF expansion 27 Kvick flow cassette 28 M Maintenance 36 37 cleaning before 36 components 36 disassembly 37 fuse replacement 36 instrumentation calibration 37 periodic 37 Material compliance 5 Membrane system labels 39 40 O Operating environment 29 Operation work flow 29 Operator qualifications 5 Parts 36 Periodic maintenance 32 Permeate pump 26 Photographic system tour 21 Power failure and back up 8 Power supply 8 Preparing the sytem for use 30 Pre
8. before use Note All GE Healthcare filter devices are tested for integrity before shipment It is prudent to test integrity before and after each process cycle be set will depend on cartridge and fiber configuration larger diameter fiber will require the valves to be more and a higher RPM 9 Record P Pou temperature and the permeate flow rate Permeate flow can be measured with a stopwatch and graduate cylinder 10 Push the STOP key on the AC Inverter 11 Drain the system using drain valve 32 User Manual 28 9335 29 AA Processing Since all feed streams behave differently it is difficult to specify exactly how to run the system This section will provide a starting point from which the path to successful processing can be developed Refer to page 7 of the GE Healthcare Operating Guide for operating considerations It is a good idea to test the system using water 10 000 NMWC ultrafiltered or better before processing valuable feed solution 1 Close all valves 2 Be sure that there is ample feed solution to process in the feed tank customer supplied 3 Open feed valve 100 to flood the pump suction side 4 Be sure that the permeate and retentate lines are directed to the appropriate destinations 5 Open the retentate valve s 100 until all the air has escaped from the system then adjust 20 open approxi mately 1 turn 6 Push the FWD key on the AC Inverter 7 Push the up arrow on the AC I
9. manner not specified by GE Healthcare you may impair the protection provided by the unit When using cross flow equipment the potential exists for personal injury unless you follow established safety procedures When using GE Healthcare products you should follow OSHA federal state and or local safety regulations for equipment installation and operation You should follow your company s safety regulations You should follow the specific safety instructions provided in this user guide and any original equipment manufacturer user guides provided with your system Only qualified personnel with training who understand the operating instructions should install operate maintain and inspect the membrane system 1 In the United States OSHA is the Occupational Safety and Health Administration User Manual 28 9335 29 AA 5 Risk assessment GE Healthcare designed and manufactured this system to provide a high level of personal safety The level of risk however is dependent on the application and environment in which the membrane system operates To ensure safe use you should perform a risk assessment The risk assessment should examine your specific application and use environment The assessment should result in user generated safety instructions over and above those provided by GE Healthcare for installation operation and maintenance Warning flags This user guide uses a warning symbol and blocks of text to provide
10. second New cartridge rinsing procedures The following Quick Flush is more than adequate for glycerin removal under most situations Refer to page 5 of the GE Healthcare Bio Sciences Operating Guide for general information about flushing glycerin from cartridges 1 Close all valves 2 Fill the clean in place CIP tank with 10 000 NMWC ultrafiltered water or better GrandStand 550 30 gallon 113 liters GrandStand 450 15 gallons 56 liters WN Open CIP feed valve 100 to flood the pump suction side 4 Be sure that the permeate and retentate lines are directed back to the CIP tank and secured Permeate side valves should be set in open position Open the retentate valve 5 100 until all the air has escaped from the system then adjust to 20 open approximately 1 turn Push the FWD key the Inverter N Push the up arrow on the AC Inverter until the inlet pressure reaches approximately 8 psig 0 55 barg 8 Adjust the pump speed and retentate valve together until inlet pressure is 10 psig 0 69 barg and outlet pressure Pou is 6 psig 0 41 barg for microfiltration cartridges For ultrafiltration cartridges use of 15 psig 1 03 barg and Pou Of 11 psig 0 76 barg After 5 minutes reduce pressure microfiltration cartridge Pa of 3 0 21 barg Pou of 2 0 14 barg Flow rates will depend on installed cartridges For example two size 45 cartridges with 1
11. the system The appendix includes an example of a typical decontamination report entitled Heath and Safety Declaration Liability Form Make sure that the cleaning procedure flushes all possible flow paths in the system After cleaning flush the entire system with water or suitable liquid to remove the CIP solution In some instances you can use the system instrumentation to monitor the removal of cleaning solution Component maintenance The OEM guides in the system documentation provide preventative maintenance recommendations for each major system component Use only spare parts recommended or supplied by GE Healthcare to maintain the proper performance of the membrane system Replacement of fuses gt Safety WARNING If you attempt to replace a system fuse without switching off the mqin power switch disconnecting the system from all electrical power supplies bodily injury can result To prevent bodily injury switching off the mqin power switch and disconnecting the system from all electrical power supplies before replacing system fuses gt Safety Table 2 Membrane system maintenance recommendations WARNING If you replace system fuses with fuses of Period Maintenance a different rating or style equipment damage or fire Before In Line filters Clean or replace filter cartridge hazards can result To prevent equipment damage or run potential fire hazards replace system fuses with the Sar
12. you need help in developing a pump curve contact GE Healthcare technical support team WARNING Placing objects or fingers into valves rotating pumps fans or other moving parts can damage the equipment and cause bodily harm Do not place objects or fingers into valves rotating pumps fans or other moving parts See the original equipment user guide if you must work on or adjust these components WARNING Moving a system without observing safety procedures can result in the system tipping over and causing bodily injury and death Before moving the system clean it shut it down and disconnect all process and utility lines If present on the system observe the warning labels concerning system moving and stability See the appendix for examples and descriptions of the warning labels used on the membrane system WARNING If you are exposed to infectious liquids originating from the system bodily harm can result To prevent illness or any other effect from infectious liquids always maintain a safe distance from the system during drainage or other activities that may involve splashing Also use appropriate personal protective equipment as described in your company s safety procedures WARNING Some membrane systems outfitted with the SIP accessory module can be steam sterilized If you touch piping and other system components during steaming burns can result Do not touch the system until you are sure that it can be done without risk
13. 0 mm ID fibers at 500 lpm flow will be approximately Pa of 10 psig 0 69 barg and Pou of 6 psig 0 41 barg NOTE The amount the retentate valve needs to be opened or how high the RPM needs to be set will depend on cartridge and fiber configuration larger diameter fiber will require the valves to be more and a higher RPM 9 Continue rinsing for at least 10 minutes 10 Push the STOP key on the AC Inverter 11 Close all the valves and allow the cartridge to soak for at least 30 minutes 12 Drain the system using the drain valve 13 Repeat steps 2 11 14 Drain the system using drain valve keeping retentate valve s open to allow air into the system User Manual 28 9335 29 AA 31 Clean water flux determination In order to evaluate cleaning processes a baseline clean water flux measurement should be established Once established comparing water flux before and after process runs will provide an idea of the effectiveness of the cleaning procedure Refer to Page 6 of the GE Healthcare Operating Guide for sample water flux calculations Microfiltration membranes are so highly permeable that water flux testing requires low pressure operation and very sensitive pressure monitoring Consult GE Healthcare Technical Support for recommendations 1 Close all valves Fill the clean in place CIP tank with 10 000 NMWC ultrafiltered water or better WN Open CIP feed valve 100 to flood the pump suction side
14. 1 Connect main pump power supply according to section Electrical System Main Power Supply on page 8 N Install any modular accessories according to the instructions supplied with each kit WN Install your membrane cassette or hollow fiber cartridge according to the instructions supplied with the cassette or cartridge holder 4 Turn the main switch to the ON position refer to P amp ID and electrical drawings Power up computer if connected to data aquisition enclosure after membrane system is on Cartridge installation 1 Place the cartridge on the outlet piping of the bottom manifold making sure that a tri clamp gasket is seated properly N Place a tri clamp gasket on the top retentate port of the cartridge WN Maintaining a firm grip on the cartridge lower the top manifold until the tri clamp gasket is seated properly Still keeping a firm grip on the cartridge clamp the inlet and outlet of the cartridge with the supplied tri clamps Install the permeate hoses keeping in mind that the permeate ports are not intended to support heavy valves flowmeters or piping as the resulting stress could damage the cartridge housing Gaskets tri clamps and adapters to flexible tubing are supplied with the system permeate hoses are customer supplied WARNING Before connecting power compare this system s specs with your power supply main voltage power phase and cycles per
15. 1 1 29 4 74 7 6 29 6 75 2 39 6 100 6 6 34 2 86 9 41 6 105 7 6 44 5 113 0 51 5 130 8 52 7 133 9 i 54 8 139 2 GrandStand 550 system housing and pipe spools dimensions continued Dimensions Not pipe spool Pipe spool Pipe spool Using both Center to center Angle housing required in cm 6 5 13 5 cm spools in cm swing elbows cm 45 39 8 101 1 15 0 38 1 20 36 35 40 0 103 4 14 8 37 6 22 33 35 5 40 0 103 4 14 1 35 8 28 21 45 5 40 8 103 6 14 0 35 6 28 96 35 5 43 1 109 5 11 7 29 7 43 01 65 z 42 3 107 4 12 5 31 8 38 62 65 5 43 3 110 0 11 5 29 1 44 05 152 45 5 115 6 9 3 23 6 54 46 55 46 0 116 8 8 8 22 4 56 63 555 46 8 118 9 u 8 0 20 3 60 00 35 2 in series 40 5 102 9 14 3 36 3 28 65 35 5 41 9 106 4 12 9 32 8 36 27 2 in series 55 STM 42 1 106 9 12 7 32 3 37 46 45 2 series 46 1 117 1 8 7 22 1 57 06 35 STM 46 7 118 6 8 1 20 6 59 59 2 in series 45 MSM DP 41 6 105 7 13 2 33 5 34 41 2 in series 75 44 5 128 3 4 3 10 9 74 41 85 51 5 130 8 3 3 8 4 78 10 85 MSM DP 52 7 133 9 2 1 5 3 Don t use swing elbows 154m 54 8 139 2 0 Don t use swing elbows User Manual 28 9335 29 AA 19 lt
16. 10 8 4 5 11 4 6 63 16 8 3 0 7 6 3 6 9 1 3 0 7 6 3 6 9 1 3 6 9 1 4 24 10 8 3 6 9 1 4 5 11 4 3 0 7 6 4 25 10 8 4 5 11 4 6 63 16 8 Permeate ports in cm 1 5 3 8 15 3 8 1 5 3 8 1 5 3 8 15 3 8 1 5 3 8 15 3 8 1 5 3 8 1 5 3 8 1 5 3 8 1 5 3 8 1 5 3 8 1 5 3 8 1 5 3 8 1 5 3 8 15 3 8 1 5 3 8 1 5 3 8 1 5 3 8 1 5 3 8 Feed Retentate Drain ports in cm 2 0 5 1 1 5 3 8 1 5 3 8 2 0 5 1 1 5 3 8 2 0 5 1 2 0 5 1 2 0 5 1 1 5 3 8 1 5 3 8 1 5 3 8 1 5 3 8 1 5 3 8 2 0 5 1 1 5 3 8 2 0 5 1 1 5 3 8 2 0 5 1 2 0 5 1 2 0 5 1 port SIP X X X X X X 0 5 0 5 0 5 X X X 0 5 X X X X X X 0 5 X X X 0 5 0 5 0 5 0 5 X X X X X X 0 5 X X X Vent Cartridge port SIP size in cm X X X 19 8 50 3 X X X 14 0 35 6 X X X 14 7 37 3 X X X 20 8 52 8 0 5 17 1 43 4 X X X 28 8 73 2 X X X 29 8 75 7 X X X 32 0 81 3 X X X 26 5 67 3 X X X 27 3 69 3 X X X 28 0 71 1 X X X 29 4 74 7 0 5 29 6 75 2 X X X 39 6 100 6 0 5 34 2 86 9 X X X 41 6 105 7 X X X 44 5 113 0 X X X 51 5 130 8 X X X 52 7 133 9 X X X 54 8 139 2 2 2 1 1 2 Total length reducers with reducers 19 8 50 3 14 0 35 6 14 7 37 3 20 8 52 8 6 17 1 43 4 28 8 73 2 29 8 75 7 32 0 81 3 6 26 5 67 3 6 27 3 69 3 6 6 28 0 7
17. 31 8 38 62 65 5 43 3 110 0 11 5 29 1 44 05 152M 45 5 115 6 9 3 23 6 54 46 55 46 0 116 8 8 8 22 4 56 63 555 46 8 118 9 8 0 20 3 60 00 35 2 in series 40 5 102 9 14 3 36 3 28 65 355 41 9 106 4 gt 12 9 32 8 36 27 2 in series 55 STM 42 1 106 9 12 7 32 3 37 46 45 2 in series 46 1 117 1 8 7 22 1 57 06 35 STM 46 7 118 6 8 1 20 6 59 59 2 in series 45 MSM DP 41 6 105 7 u 13 2 33 5 34 41 2 in series 75 44 5 128 3 4 3 10 9 74 41 85 51 5 130 8 3 3 8 4 78 10 85 5 52 7 133 9 u 2 1 5 3 Don t use swing elbows 154m 54 8 139 2 0 Don t use swing elbows 18 User Manual 28 9335 29 AA GrandStand 550 system housing and pipe spools dimensions Dimensions housing 45 35 35 SMO DP 45 SMO DP 35 STM 65 65 MSM DP 152M 55 55 SMO DP 35 2 in series 35 SMO DP 2 in series 55 STM 45 2 in series 35 STM 2 in series 45 MSM DP 2 in series 75 85 85 MSM DP 154m Length cm 19 8 50 3 14 0 35 6 14 7 37 3 20 8 52 8 17 1 43 4 28 8 73 2 29 8 75 7 32 0 81 3 26 5 67 3 27 3 69 3 28 0 71 1 29 4 74 7 29 6 75 2 39 6 100 6 34 2 86 9 41 6 105 7 44 5 113 0 51 5 130 8 52 7 133 9 54 8 139 2 Diameter in cm 4 24 10 8 3 0 7 6 3 6 9 1 4 5 11 4 3 6 9 1 4 25
18. GE Healthcare GrandStand System Instructional Manual GrandStand Modular Membrane Systems Important user information Users must read this entire manual to fully understand the safe use of GrandStand modular membrane systems Terms and conditions of sale Unless otherwise agreed to in writing all goods and services are sold subject to the terms and conditions of sale of the company within the GE Healthcare group that supplies them You can request a copy of these terms and conditions from GE Healthcare Should you have any comments on this product please notify GE Healthcare Bj rkgatan 30 751 84 Uppsala Sweden 2 User Manual 28 9335 29 AA Table of contents Chapter 1 System Documentation and Safety About this user guide 5 Audience 5 Where to find more information 5 System documentation 5 Material compliance 5 Safety compliance and design standards 5 Safety 5 Warning flags 6 Warning symbols 6 Safety warnings 6 Chapter 2 System Description Introduction 8 Electrical system 8 Chemical compatibility 9 Hardware high pressure shut off 9 Weights and dimensions 9 Chapter 3 Photographic System Tour GrandStand system modular accessories 21 Data acquisition enclosure 22 Cable connection key 22 Flow meter 23 Temperature sensor 23 Pressure indicators 24 Feed line pressure indicator 24 Conductivity sensor 25 UV sensor 26 Permeate pump 26 SIP kit 27 Four position HF expansion kit 27 Kvick flow cassette kits 28
19. GE SOLUTION FLUSHING ON RETENTATE LINE 4 OPTION FLOWMETER ON RETENTATE LINE 5 OPTION PRESSURE INDICATING TRANSMITER ON RETENTANTE LINE THE STANDARD UNIT INCLUDE PRESSURE INDICATOR 6 OPTION PRESSURE INDICATING TRANSMITER ON PERMEATE LINE THE STANDARD UNIT INCLUDE PRESSURE INDICATOR 7 OPTION PERISTALTIC PUMP ON PERMEATE LINE 8 OPTION UV ON PERMEATE LINE 9 OPTION CONDUCTIVITY ON PERMEATE LINE 10 OPTION TEMPERATURE INDICATING TRANSMITER ON FEED LINE 11 OPTION PRESSURE INDICATING TRANSMITER ON FEED LINE THE STANDARD UNIT INCLUDE PRESSURE INDICATOR 12 FOR GRANDSTAND 550 WITH 4 POSITIONS THE PUMP INCLUDE DOUBLE HEAD WITH MAX FLOW RATE 66 6 liter min 13 OPTION FOR SIP ADD STEAM TRAP TO DRAIN VALVE User Manual 28 9335 29 AA 15 GrandStand 450 System TK 4501 27 450 001 55 1 NOTE 11 4501 FL 4502 PU 4503 TANK SCREEN GASKET RECIRCULATION PUMP CAS GALLONS 60 LPM 45 PSD 16 User Manual 28 9335 29 AA NOTES 1 SEE P amp ID DTL 001 CARTRIDGE DETAILS 2 OPTION VALVE 172 FOR STORAGE SOLUTION FLUSHING 4 3 OPTION FLOWMETER ON RETENTATE LINE SERS URINE BE REE sess S OPTION PRESSURE INDICATING TRANSMITER ON PERMEATE LINE THE STANDARD UNIT INCLUDE PRESSURE INDICATOR 6 OPTION PERISTALTIC PUMP ON PERMEATE LINE 7 OPTION UV ON PERMEATE LINE NOTE 8 NOTE 7 8 OPTION CONDUCTIVITY ON PERMEATE LINE TEMPERATURE INDICATING TRANSMITER
20. ON FEED 10 OPTION PRESSURE INDICATING TRANSMITER FEED LINE THE STANDARD UNIT INCLUDE PRESSURE INDICATOR 11 OPTION FOR SIP ADD STEAM TRAP DRAIN VALVE PU 4504 PERISTALTIC PUMP N MARLOW Model SN RE ax flow rate 18 liter min User Manual 28 9335 29 AA 17 GrandStand 450 system housing and pipe spools dimensions Dimensions Length Diameter Permeate Feed Retentate Drain Vent Cartridge 2 2 1 1 2 Total length housing cm cm ports cm ports in cm port SIP port 51 size reducers with reducers 45 19 8 50 3 4 24 10 8 1 5 3 8 2 0 5 1 X X X X X X 19 8 50 3 19 8 50 3 35 14 0 55 6 3 0 7 6 1 5 3 8 1 5 3 8 X X X X X X 14 0 35 6 6 14 0 35 6 35SMO DP 14 7 37 3 3 6 9 1 1 5 3 8 1 5 3 8 0 5 X X X 14 7 37 3 6 14 7 37 3 45 SMO DP 20 8 52 8 4 5 11 4 1 5 3 8 2 0 5 1 0 5 X X X 20 8 52 8 20 8 52 8 35 STM 17 1 43 4 3 6 9 1 1 5 3 8 1 5 3 8 0 5 0 5 17 1 43 4 6 17 1 43 4 65 28 8 73 2 4 25 10 8 1 5 3 8 2 0 5 1 X X X X X X 28 8 73 2 28 8 73 2 65 MSM DP 29 8 75 7 4 5 11 4 1 5 3 8 2 0 5 1 0 5 X X X 29 8 75 7 29 8 75 7 152M 32 0 81 3 6 63 16 8 15 3 8 2 0 5 1 X X X X X X 32 0 81 3 gt 32 0 81 3 55 26 5 67 3 3 0 7 6 1 5 3 8 1 5 3 8 X X X X X X 26 5 67 3 6 26 5 67 3 55 SMO DP 27 3 69 3 3 6 9 1 1 5 3 8 1 5 3 8 0 5 X X X 27 3 69 3 6 27 3 69 3
21. a same type and rating of fuse Test alarm Use instruction in control system buzzer If a fuse repeatedly blows shutdown the membrane Weekly Tubing and Inspect the system for leaks system main switch and contact your local connectors GE Healthcare representative Monthly Tubing Leakage test of the piping connectors system and inspection of tubing l I sensors qnd sensors for internol coqting Instrumentation calibration s For reliable performance calibrate the system instrumentation Pumps Check oil level Inspect for coating according to monufacturer s recommendation and the recommendations Table 2 rust etc Refer to the pump instruction manual the system documentation for specific Calibration compares the instrument to a known reference maintenance requirements If instrument adjustments necessary GE Healthcare Uv manitor Replies Wie tw recommends that you contact the instrument manufacturer or as intensity or lamp failure is or GE Healthcare for help necessary indicated Refer to the UV monitor instruction manual in the system documentation Voiding of warranty Any warranty provided with the membrane system become void if instruments are adjusted by anyone other than GE Healthcare service personnel the instrument manufacturer s All components Replace gaskets O rings and service personnel or personnel authorized by GE Healthcare diaphragms Pumps Replace wear components Re
22. an be supplied at an additional cost These systems include membrane cassette and hollow fiber cartridge versions The membrane systems enable users to separate concentrate and or diafilter biological solutions with precision These systems come configured for membrane cassettes or hollow fiber cartridges By using conversion kits and rearranging components GE Healthcare representatives can convert some standard membrane systems from a cassette system to a hollow fiber system or vice versa System types The data aquisition accessories do not automatically monitor and regulate the membrane process control equipment The operator must manually operate the pumps and valves and monitor the process conditions The data aquisition accessories do collect process data for later analysis and display when exported to a computer with Microsoft Excel Electrical system Main power supply The system label on the membrane system provides the power requirements and consumption information The power consumption on the system label states the maximum amperage consumption during full load of the equipment The system documentation also provides additional power requirement information for proper operation of the system When replacing a damaged power cable use a replacement cable of the same type and dimensions 8 User Manual 28 9335 29 AA gt Safety WARNING If the power supply you use is not grounded to earth equipment damage and bo
23. be 120 L min 30 psig 2 07 bar EPDM 9 5 L 2 5 gol GSMRLP450 SYS 220 VAC 3 Phase 50 60 Hz GSMRLP450 380V 380 VAC 3 Phase 50 60 Hz GSMRLP450 440V 440 VAC 3 Phase 50 60 Hz GrandStand 550 system specifications Base system GrandStand 550 Weight approximate Materials of Construction Frame Fluid path Fluid path surface finish Kvick Flow holder surface finish Front and back plate Feed retentate permeate ports CIP tank Pump Type Max Pump Flow rate O rings gaskets valve diaphragms System dead volume Power requirements 1876 Ibs 851 kg 304 stainless steel 316 L stainless steel lt 20 Ra pin 0 5 Ra um lt 25 Ra yin 0 6 Ra um lt 20 Ra yin 0 5 Ra um 30 gal Polypropylene 113 5 L Rotary lobe 400 L min 30 psig 2 07 bar EPDM 18 9 L 5 gal GSMRLP550 SYS 220 VAC 3 Phase 50 60 Hz GSMRLP550 380V 380 VAC 3 Phase 50 60 Hz GSMRLP550 440V 440 VAC 3 Phase 50 60 Hz Approximate base system without tank or filter cartridge Note To determine minimum working volume add volume of filter holder tank working volume to system dead volume User Manual 28 9335 29 AA 9 GrandStand 550 System ee 5 IN I 6 10 3 16 2088 mm User Manual 28 9335 29 ay HS lt gt ZIN KS Z CY 11 User Manual 28 9335 29 GrandStand 450 System 1905
24. dily injury can result To avoid equipment damage and bodily injury always connect the system to a grounded protected earth power supply Review local electrical code details to ensure that the type of power cable and other features are compliant Fuses The membrane system main power supply is equipped with a circuit breaker inside the cabinet The system documentation and the original equipment user guides supply information on internal power supply and instrument fuses Power failure and back up If the control system loses electrical power the membrane system pumps stop But the system may remain pressurized The data collected during the run is saved up to the last autosave which by default occurs every five minutes You should use an uninterrupted power supply UPS for the computer system used to log data to avoid the loss of data during a power failure gt Safety WARNING During a power failure or if the emergency stop button is pressed the system may remain pressurized Opening a line or vessel at this point could result in the release of potential hazardous process cleaning fluid cause bodily harm When recovering from q power failure or emergency shutdown ensure all lines and vessels are depressurized before opening them up Emergency stop The membrane systems are equipped with one red emergency stop button Pushing the red emergency stop button cuts power to all electrically powered equip
25. e system are recognized as safe for use in food and drug handling equipment as described for Good Manufacturing Practice by the U S Food and Drug Administration You should review the system documentation to ensure the system is suitable for your needs and specific application Safety compliance and design standards GE Healthcare designed the system for electrical installation in accordance with the prevailing standards in the country of destination CE marked membrane systems standard and custom systems comply with EU directives and standards described in the system documentation The compliance with the directive is valid under the condition that you install operate and maintain the membrane system according to the system documentation and this user guide To maintain compliance use only spare parts approved or supplied by your local GE Healthcare representative Safety Anyone who works with the membrane system should read understand and follow the instructions in this user guide before using the system If any operator does not understand an instruction they should stop working with the membrane system and contact GE Healthcare for guidance You should save these instructions and make them available to all users of the membrane system GE Healthcare designed the membrane system for pilot and production scale filtration of biological solutions under the conditions stated in this user guide If you use the membrane system
26. ers and either leave them in the system for short term storage or removed them for long term storage To learn how to clean membrane filters consult either the Hollow Fiber Operating Handbook 18 1165 30 AB or the Kvick Lab and Kvick Flow Cassettes User Manual 18 1171 69 AG These documents can be requested from GE Technical Services Cleaning the exterior of the membrane system After each run clean the exterior of the system to remove contaminates Wipe the exterior of the system down with clean water to remove any buildup of process and cleaning solutions Dry the exterior components with a lint free cloth Cleaning individual components Some of the components such as conductivity probes have special cleaning requirements Refer to the original manufacturer s user guides located in the system documentation to learn about cleaning these components Short term storage For short term storage less than ten days perform the cleaning procedures summarized above Cleaning section on page 34 then follow these steps 1 Fill the system with 0 1M NaOH and circulate for 10 to 15 minutes The NaOH will prevent any bacterial growth inside the system 2 End the cycle and shut down the computer system 3 Switch the system s main power switch to OFF 4 Release back pressure valves 34 User Manual 28 9335 29 AA WARNING Do not drain system Do not allow membranes to become dried out during storage Long term storage To s
27. esses the needs of scientists process engineers and technicians who operate pilot scale and production scale cross flow systems The level of information in this guide assumes the user possesses basic laboratory and technical skills The user should have the knowledge and documentation to operate safely any user supplied equipment connected to the membrane system If you need assistance with the instructions in this guide contact GE Healthcare for more information Where to find more information In the USA you can contact our customer and technical support teams by calling 1 800 526 3593 Outside of the USA you can contact your local GE Healthcare representative using the telephone numbers listed at the back of this user guide You can also receive customer and technical support by emailing us at these addresses Technical Support ts usa ge com System documentation In addition to this user guide you receive binders containing specific documentation for the membrane system such as general specification equipment list P amp ID spare parts list inspection and test plan inspection reports functional test report installation test report calibration and performance certificates panel layout electrical schematics 1 0 list and material specifications Material compliance The system documentation describes the design and materials of construction of the membrane system The wetted materials of construction in the membran
28. fer to the pump instructions manual in the system documentation Disassembly and assembly The operator must read and understand the instructions for system components before removing and installing them Contact your local GE Healthcare representative for additional information or help if needed gt Safety WARNING Disassembling the membrane system without shutting it down depressurizing it and disconnecting all utilities can result in bodily injury from the accidental start up of the pump or unexpected release of pressure To prevent bodily injury shut down the system depressurize it and disconnect the utilities before disassembling the system After assembly you must test the piping system for leaks at the maximum system pressure for continued protection against injury risks due to water jets or burst pipes refer to leakage test in the system documentation Periodic maintenance The maintenance recommendations differ depending on frequency of use Hence use the recommendation as a guideline and develop your own maintenance schedule based on use and experience Table 2 User Manual 28 9335 29 AA 37 Chapter 9 Service and Training Service Your local GE Healthcare representative can provide you with information about system servicing Training GE Healthcare recommends that new operators attend membrane system training at GE Healthcare This training provides the information necessary for inexperienced o
29. h cable ties Temperature sensor The temperature sensor is mounted vertically on the feed line where indicated on the installation guide Locate the piping end cap remove the tri clover clamps and gasket Replace the end cap with the temperature sensor Reassemble the tri clover clamps and gaskets and tighten sufficiently to seal the process piping Connect data transmission cable Position the cable along the system frame from the sensor to the data acquisition enclosure and secure with cable ties User Manual 28 9335 29 AA 23 Pressure indicators The pressure indicators are mounted on the feed retentate and permeate lines as purchased where indicated on the installation guide For the feed line the pressure indicator replaces the pressure gauge Remove the tri clover clamp gasket and pressure gauge Replace the pressure gauge with the pressure indicator and reassemble with the clamp and gasket Feed line pressure indicator For the retentate line the pressure indicator is placed at the end of the retentate piping to facilitate local readout viewing Remove the tri clover clamp end cap and gasket Replace the end cap with the pressure indicator and reassemble with the clamp and gasket The end cap may be is used to replace the pressure gauge on the retentate line above the filter positions The permeate pressure indicator is assembled within the permeate line when the system includes a permeate pump kit or may be asse
30. iences Health amp Safety Declaration Form ensure the mutual protection and safety of Gt Healthcare s service personnel and our customers all equipment and work areas must be clean and free of any contaminants before a Service Engineer starts a repair To avoid delays in the servicing of your equipment please complete this Declaration Form and present it to the Service Engineer upon arrival RA and or Service Tickel Request 1 Please note that equipment will be accepted for servicing or return until this form is properly completed 2 Failure to complete the form completely accurately and truthfully can endanger GE Healthcare personnel 3 Equipment and or work areas not sufficiently cleaned and safe for engineer arrival or prior to return of equipment to GE Healthcare may lead to delays in servicing the equipment and could be subject to additional charges Equipment type Product No Please specify if the equipment has been in contact with any of the following Yes No Serial No O Radioactivity specify es infectious or hazardous biological substances please specify 1 hereby confirm that the equipment specified above has been cleaned to remove any hazardous substances or sanitation solution with exception of the named liquids see lower right on this form also Yes No agree to give GE Healthcare sole control of the system equipment O Other tazardous Chemical
31. ks are the property of their respective owners 2007 General Electric Company All rights reserved All goods and services are sold subject to the terms and conditions of sale of the company within GE Healthcare which supplies them A copy of these terms and conditions is available on request Contact your local GE Healthcare representative for the most current information Contact your local GE Healthcare representative for the most current information GE Healthcare Bio Sciences AB Bj rkgatan 30 751 84 Uppsala Sweden GE Healthcare Bio Sciences Corp 800 Centennial Avenue P O Box 1327 Piscataway NJ 08855 1327 USA GE Healthcare Europe GmbH Munzinger Strasse 5 D 79111 Freiburg Germany GE Healthcare Bio Sciences KK Sanken Bldg 3 25 1 Hyakunincho Shinjuku ku Tokyo 169 0073 Japan 28 9335 29 AA 12 2007
32. ly mounted or wrong size sized gaskets Sanitary clamp loose Tighten sanitary clamp Feed pressure is too high Membrane filter is fouled Clean the membrane filter Obstruction in feed line or retentate line Inspect lines for obstruction Feed inlet in the membrane filter plugged Switch feed and retentate lines to reverse flow and rinse with deionized water or WFI Pump speed setting too high Either open retentate valve to allow more flow or reduce pump speed System leaks during integrity testing Improperly seated or damaged gasket at Locate leaking area by feeling air leak sanitary fitting with hand or by applying soapy water and looking for bubbles Remove inspect and reinstall sanitary fitting gaskets Faulty valve Check integrity of valves and replace as needed User Manual 28 9335 29 AA 35 Chapter 8 Maintenance gt Safety WARNING Inspecting and maintaining the membrane system without shutting it down depressurizing it and disconnecting all utilities can result in bodily injury from the accidental start up of the pump or unexpected release of pressure To prevent bodily injury shut down the system depressurize it and disconnect the utilities before inspecting and maintaining the system Parts The system documentation lists replacement parts and spare parts Inspection Periodically based on use and applications perform the following inspections and maintenance e Inspect process piping and co
33. mbled in a customer supplied permeate line if properly supported When reassembling tri clover clamps and gaskets tighten sufficiently to seal the process piping Connect data transmission cables as indicated in the connection key above Position the cable along the system frame from the sensor to the data acquisition enclosure and secure with cable ties 24 User Manual 28 9335 29 AA Conductivity sensor The conductivity sensor is mounted on the permeate line supplied as part of the kit where indicated on the installation guide The readout is mounted on the frame in position E adjacent to the data acquisition enclosure using frame mounted studs and nuts Connect the power and data transmission cables as indicated in the cable connection diagram above Position the cables along the system frame from the sensor to the data acquisition enclosure and secure with cable ties User Manual 28 9335 29 AA 25 UV sensor The UV sensor is mounted on the permeate line supplied as part of the kit where indicated on the installation guide Connect the data transmission cables as indicated in the cable connection diagram above Position the cables along the system frame from the sensor to the data acquisition enclosure and secure with cable ties 26 User Manual 28 9335 29 AA Permeate pump The permeate pump is mounted on the frame where indicated on the installation guide position G below the CIP tank Secure the kit plate with
34. ment and stops the system You can also use the main switch to quickly stop the system If there is no risk of personal injury use the normal shut down procedure to shut the system down Chemical compatibility All wetted parts have specific chemical resistances See the system documentation for additional information You must ensure the suitability of the process chemicals you use You must consider the compatibility of the wetted parts and your process chemicals so that no negative interaction takes place and so that your process chemicals do not damage the system components compromising the safety of the system Contact your local GE Healthcare representative if you are not sure of the compatibility of your chemicals gt Safety WARNING If you use chemicals that are not compatible with the wetted parts of your system equipment and product damage can result Equipment failure leading to leaks and bodily injury can result To avoid equipment damage and bodily injury do not use incompatible chemicals in the membrane system All wetted parts have specific chemical resistances See the system documentation for additional information Hardware high pressure shut off system gt Safety WARNING If you disconnect the system s hardware driven high pressure shut off safety system overpressurization can lead to equipment damage or the unexpected release of pressure process and cleqning fluids leading to bodily injury
35. mm 5 F YN a a Ee Lu CC i x __ oO Al 6 6 1 2 1993 mm 12 User Manual 28 9335 29 Mf MLA mS ks s SE s OF 7 Ny i lt 6 awe 2 N 7 s A ZS 7 GrandStand 550 System 5501 30 GALLON 3 550 001 5571 NOTE 10 3 P 550 002 SST1 j lj l a j lj I FL 5502 j j l L _I L 1 w 5 5503 1 mM i aD 1 1 I 13 FEED 1 7 1 2 3 550 003 5571 V 106__ 4 se 2 P 550 004 SST1 5501 FL 5502 PU 5505 CIP TANK SCREEN GASKET RECIRCULATION PUMP PP CONE BOTTOM 30 MESH UNIBLOC PD 550 WATSON 30 GALLONS 60 LPM 45 PSID 230 460VAC 3PH 7 5 HP 14 User Manual 28 9335 29 AA J 1 T 4 L j _V 104_ j 11 2 pa p PU 9504 PERISTALTIC PUMP 5 1 P 550 007 SST1 NOTE 9 NOTE 8 PU 5504 NOTE 7 NOTE 12 17 6 RLOW Model eye or_ 720SN RE REX Flow Rate 8 8 l min NOTE 12 NOTES 1 SEE P amp ID DTL 001 CARTRIDGE DETAILS 2 OPTION ADD 2 POSITIONS ON GRANDSTAND 550 3 OPTION VALVE 1 29 FOR STORA
36. nnections for damage or leaks e Inspect electrical connections for proper fit e Inspect the sanitary connection gaskets for damage or wear and replace the gaskets as needed e Inspect system components following the recommendations in the original manufacturers user guides Maintenance Lubricate and calibrate system components in accordance with the recommendations in the original manufacturers user guides located in the system documentation GE Healthcare recommends that you purchase preventative maintenance services from GE Healthcare Proper maintenance ensures that the system performs in accordance with GE Healthcare specifications General For maintenance on specific instruments read and follow the instructions in the OEM manuals in the system documentation 36 User Manual 28 9335 29 AA Membrane systems are designed to require a minimum of service and maintenance This chapter describes procedures for sanitizing and cleaning in place for routine component maintenance gt Safety WARNING Only trained personnel or personnel with equivalent knowledge of similar equipment should complete system maintenance or service Cleaning before maintenance service Clean the system of infectious or aggressive fluids before service or maintenance Document the cleanliness by completing a decontamination report You must supply a decontamination report before a GE Healthcare service technician can work on
37. nstallation and operation of SIP hollow fiber cartridges Four position HF expansion kit The four position HF expansion kit is mounted to the feed and retentate lines to the left of the 2 filter positions already installed as indicated in the installation guide diagram Each filter position includes inlet and outlet valves and piping spool pieces Assemble each position to the feed and retentate lines using tri clover clamps and gaskets using this photo as a guide Each position has at the retentate side a set of two 180 elbows and one 90 elbow The elbow assemblies are configured as indicated in the housing and pipe spool matrix on page 19 of this manual When assembling tri clover clamps and gaskets tighten sufficiently to seal the process piping User Manual 28 9335 29 AA 27 Kvick flow cassette kits The Kvick Flow cassette kits are installed in position K as indicated on the installation guide diagram In order to install the Kvick Flow kits the hollow fiber cartridge position spool pieces are removed The frame structural components of the kit are installed using the studs and nuts provided on the frame GrandStand 450 is limited to one set of 2 Kvick Flow holders and therefore can accommodate one 1 kit Grandstand 550 allows for 2 4 or 6 holders therefore accommodate one 1 two 2 or three 3 kits Be sure to secure the kits to the base and to the horizontal frame component at the appropriate heights for the number
38. nuts pro vided on the system Ref item A location in the system schematic The enclosure is plugged directly into a wall outlet The enclosure provides 24VDC power to the data acquisition modules See data acquisition connectology diagram for power and data collection positions for each of the modules Cable connection key Yellow cables are power cables Ais for enclosure power cord B is for permeate pump power cord C is for conductivity meter power D is for UV sensor power E is for retentate flow meter power Purple cables are data transmission cables J1 is for feed temperature sensor J2 is a spare J3 is for feed pressure indicator J4 is for retentate flow meter readout J5 is for retentate pressure indicator J6 is for permeate pressure indicator J7 is for UV sensor J8 is for conductivity sensor 22 User Manual 28 9335 29 AA Flow meter The retentate flow meter is mounted on the retentate line where indicated on the installation guide Locate the piping spool piece remove the tri clover clamps and gaskets and spool piece Replace the spool piece with the flow meter positioning the flow meter readout below the retentate line and facing the back of the system Reassemble the tri clover clamps and gaskets and tighten sufficiently to seal the process piping Connect power and data transmission cables Position the cables along the system frame from the flow meter to the data acquisition enclosure and secure wit
39. nverter until the inlet pressure reaches approximately 8 psig 0 55 barg 8 Adjust feed flow and transmembrane pressure to suit your process requirements If performing a microfiltration process TMP will be governed by permeate flow control options NOTE The amount the retentate valve needs to be opened or how high the RPM needs to be set will depend on cartridge and fiber configuration larger diameter fiber will require the valves to be more and a higher RPM 9 Record Phn Pou temperature and the permeate flow rate as a function of time Permeate flow can be measured with a stopwatch and graduate cylinder 10 Push the STOP key on the AC Inverter 11 Drain the system using drain valve 12 With microfiltration cartridges it is common to restrict the permeate flow to a pre set level Permeate flow control can be regulated by a valve or peristaltic pump This practice promotes increased throughputs and improved processing User Manual 28 9335 29 AA 33 Chapter 6 System Cleaning and Storing Cleaning To ensure that the membrane filtration system performs properly and to extend its service life clean and store the system as described below Cleaning the membrane filters Membrane filters require cleaning using specific cleaning solutions and procedures The membrane cassettes and hollow fiber cartridges are normally cleaned while installed on the system Recirculate cleaning solutions through the membrane filt
40. of kits installed The Kvick flow manual holder is mounted to the horizontal plate for each kit Kvick Flow holder ports are connected to the system feed and retentate lines using the manifold provided as part of the kit These are connected to the system such that the manifold is positioned between the Kvick Flow holders which face each other see graphics below UP AF oe Fig 5 450 Installation Diagram 28 User Manual 28 9335 29 AA Fig 6 550 Installation Diagram 4 Using the Membrane System Introduction Systems with data acquisition accessories installed use soft ware installed on a nonintegrated computer the software only provides data collection and data display functions Data acquisition operating environment Enclosure transfers data to computers under Microsoft Windows NT 4 00 Windows 2000 or Windows using the English keyboard settings Connect cable to RS232 port according to instructions in documentation package Work flow For data logging systems you control the run manually After completing the run you can transfer the data to a Microsoft Excel spreadsheet User Manual 28 9335 29 AA 29 Chapter 5 System Preparation General This chapter describes the initial start up and testing procedures for membrane systems The procedures below assume you have installed the system in accordance with the installation instructions in this guide and that the
41. perators to safely operate the membrane system To arrange training contact your local GE Healthcare representative 38 User Manual 28 9335 29 AA Appendix The appendix includes the membrane system label system warning labels and an example of a decontamination report Membrane system label This is a typical system label that provides users with electrical supply requirements and operating parameters This label indicates the maximum operating pressure of the system s process lines and process equipment Exceeding this pressure can cause bodily harm and equipment failure CATALOG No GSMRLP550380V SYSTEM SERIAL No 550 4 YEAR OF MANUFACTURE 2008 SUPPLY VOLTAGE SYSTEM 380 V FREQUENCY 50 60 Hz MAX CURRENT REQUIREMENT SYSTEM 30 MOTOR SIZE 5 50 kW gt PROCESS PRESSURE 45 PSIG GE Healthcare CABINET PROTECTION CLASS NEMA 4X IP68 User Manual 28 9335 29 AA 39 Membrane system warning labels This label indicates the emergency stop switch im Emergency stop This label indicates hazardous moving parts Keep hands away during operation WARNING Keep hands away from moving machine parts This label indicates hazardous surface temperature during operation WARNING Hot surface 40 User Manual 28 9335 29 AA Health and Safety Declaration Liability Form This document indicates the decontamination procedure you should follow before servicing the system GE Healthcare Life Sc
42. personnel performing these tasks have the appropriate knowledge of the system and the application GE Healthcare engineers test all membrane systems before shipping The system documentation contains the results of the system tests Checking pump oil Read the pump user guide to ensure you understand its operation and maintenance before using the system Ensure that the pump transmission is filled with lubricant 30 User Manual 28 9335 29 AA System installation The GrandStand System as shipped requires minor on site assembly and minimal effort to initiate operation It is the customer s responsibility to follow all National and Local codes pertaining to both plumbing and electrical connections 1 Unpackage the system carefully Some components such as the pressure gauges are easily damaged if handled roughly 2 Install the pressure gauges with a gasket and tri clamp to the inlet and outlet manifolds 3 Install any modular accessory kits that were purchased 4 Install the customer supplied retentate and permeate piping 5 Connect the AC inverter into local electrical power main supply following all electrical codes and referring to AC inverter manual Failure to properly connect the inverter can severely damage the inverter and or motor A qualified electrician should perform this work and make sure the pump is rotating properly Starting the system Ensure these items are complete before starting the system
43. priate personal protection devices and clothing when operating and cleaning the system 6 User Manual 28 9335 29 AA WARNING Membrane systems accept membrane cassettes or hollow fiber cartridges depending on the model Using cassettes or cartridges without opening the packing properly can expose you to potentially hazardous solutions Read the safety instructions provided with your membrane cassette or hollow fiber cartridge and follow the instructions when opening the package WARNING Using tap water to flush or rinse your membrane system can plug the pores of the membrane with the relatively large particulates rust dirt minerals bacteria etc found in tap water To prevent plugging the pores of the membrane always use 0 2 Im filtered or water for injection WFI when rinsing or flushing the membrane system or when making up cleaning solutions or adding dilution water to process fluids In this user guide the term clean water means 0 2 im filtered water WFI WARNING Data Logging accessories do not offer automatic process control Hence many users normally establish pump curves for the system configuration they plan to use By establishing a pump curve they can quickly and accurately set the pump speed to achieve the recommended flow rate during processing To determine the flow rate without a pump curve you would have to disconnect the retentate line and measure the flow rate using a graduated cylinder and stopwatch If
44. s please specify specified abovel Equipment must be decontaminated prior to service return Please provide a Name in phone number where GE Healthcare can contact you for additional information Gida concerning the system equipment Position in Institution Liquid and or gas in equipment 15 Date Year month date n WERT Berd OWoter O thonol ONone empty Argon Helium Nitrogen Liquid Nitrogen Other please specify Liability Form servicing only 1 hereby confirm that have taken full responsibility and control over the Changes Improvements on system or equipment system equipment O See PM document Engineer onasini O See Service report Name in None IE SENEO EEEE A IEOR The owner of the system equipment confirms by signing in the service report Nate that has accepted tn take the fill responsihility and control Year month date a a IO RECEIVE A REIURN AU HORIZAIION NUMBER OR SERVICE NUMBER CALL LOCAL TECHNICAL SUPPORT or CUSTOMER SERVICE NUMBER 70 5009 65 AH Valid from 2007 12 04 GE imagination at work User Manual 28 9335 29 AA 41 Index A Appendix 39 40 41 42 43 Audience for user guide 5 C Cable connection key 22 Calibration of instruments 37 Cartridge installation 31 Caution flags 8 Chemical compatibility 9
45. safety warnings gt Safety WARNING safety warning flag describes conditions or actions that can cause bodily harm and describes how to avoid the risk You must follow the warning statement for safe operation of the membrane system Warning symbols The membrane hardware uses warning symbols to warn operators of potentially harmful conditions or actions The appendix includes examples and descriptions of the equipment warning symbols used on the membrane system Safety warnings WARNING The maximum operating pressure of the system s process equipment and process lines is 4 1 barg 60 psig If this pressure is exceeded during integrity testing equipment failure and bodily injury can result To ensure proper operation and to prevent equipment failure and bodily injury do not exceed an air inlet pressure 6 barg 90 psig to the process lines during integrity testing For the membrane system the maximum operating pressure is 4 1 barg 60 psig Wear the appropriate personal protection devices when testing the system If a cross flow system leaks it can release potentially hazardous process fluids or cleaning fluids causing bodily harm To prevent leaks and the release of potentially hazardous fluids limit feed pressure to 4 1 barg 60 psig for membrane systems Isolate and depressurize the system before disassembling it Periodically inspect the system s gaskets seals and connections for wear and damage Wear the appro
46. ssure hold and integrity tests 32 Pressure indicators 24 Processing 33 Pump oil 30 R Risk assessment 6 Rinsing procedures 31 S Safety 5 6 7 risk assessment 6 Safety compliance and design standard 5 Safety warnings 6 7 Service 38 SIP kit 27 Software modules 23 Starting the system 21 Storage 34 long term 34 short term 34 Storage conditions 34 System cleaning 34 36 description 8 documentation 5 inspection 29 installation 30 31 maintenance 36 37 networks 23 processing 33 rinsing 31 service 38 startup 31 storage 34 training 38 troubleshooting 35 types 8 work flow 29 T Technical documentation 6 Technical support 5 Temperature sensor 23 Terms and conditions of sale 2 Training 38 Troubleshooting 35 Troubleshooting chart 35 U Unpacking the system 30 User guide introduction 5 User manuals 5 Using the system 29 UV sensor 26 V Voiding of warranty 37 W Safety warnings 6 Warning flags 6 Warning symbols 6 Warranty 37 User Manual 28 9335 29 AA 43 For contact information for your local office please visit www gelifesciences com contact GE Healthcare Bio Sciences AB Bj rkgatan 30 751 84 Uppsala Sweden www gelifesciences com imagination at work GE imagination at work and GE monogram are trademarks of General Electric Company GrandStand is a trademark of GE Healthcare companies All third party trademar
47. the studs and nuts found on the frame The pump selected rests on the plate and connects to the data acquisition enclosure as indicated in the connection diagram Position the cable along the system frame from the pump to the data acquisition enclosure and secure with cable ties The permeate pump is typically used to restrain the flow from microfiltration cartridges to a preset level When cartridges are arranged in parallel the top permeate lines can be manifolded to a single tube passing through the pumphead When cartridges are arranged in series the flows must be segregated using multiple heads on the permeate pump Consult GE Healthcare Technical Support for specific recommendations SIP kit The SIP kit is installed in position H of the installation guide diagram Loosen and remove the tri clover clamp gasket and drain valve from the end of the feed line Position the steam trap between the drain valve and the feed line low point Install the steam trap and drain valve using the tri clover clamps and gaskets When reassembling tri clover clamps and gaskets tighten sufficiently to seal the process piping Note Second set of valves and steam traps are required for the permeate side of the stainless steel housing s and SIP cartridge intended for your process Stainless steel housing and permeate side connections must be purchased separately Refer to the Steam Sterilization Handbook 18 1174 71 AA for more details on proper i
48. tore the system more than 10 days perform the cleaning procedures summarized in the Cleaning section on page 34 then follow these steps Fill the system with 0 5M NaOH and circulate for 10 to 15 minutes N End the cycle and completely drain the system WGN Disconnect all process lines from the system and blank off the connection points using sanitary end caps gasket and clamp Remove flex tubing on permeate side 4 Remove the membrane cassettes or hollow fiber cartridges and store them according to their instructions Shut down the computer system nO Switch the system s main power switch to the OFF position N Disconnect all utility lines from the system System is now ready for storage After long term storage system may require several cleaning cycles before use Perform a calibration of all monitors and perform a leakage test before putting the system into production Storage conditions Storage requirements include these Temperature 10 to 50 C Relative humidity 0 to 100 non condensing Chapter 7 Troubleshooting Troubleshooting guide If the membrane system does not work properly consult the troubleshooting guide Table 1 Table 1 Membrane system troubleshooting guide Symptom Possible Cause Solution Process solution leaks from sanitary Sanitary connection gasket missing worn Replace worn damaged or improperly connections damaged improper
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