REACH-IT Industry User Manual
Contents
1. Clients connecting to the server provide user name and password Document Version 1 6 Page 18 of 21 October 2013 Lg 2 Pere TOOLBOX QSAR Toolbox User Manual Toolbox 3 2 Client Server Configuration When in Domain configuration All domain users have granted DCOM access launch and activation rights The server object runs under an account granted with access launch and activate rights Clients access the server from Toolbox start up screen as current user 4 3 2 Common errors Error The RPC server unavailable Access denied Client is compiled with different server access library Interface not Document Version 1 6 October 2013 Possible Issues The computer really doesn t exist The Windows Firewall on the server is blocking the connection DCOM is not enabled Client firewall blocks connection The user does not have remote access to the computer through DCOM The client and server versions does not match The implementation Toolbox Solution Add Toolbox server application TBServerV3 exe to the firewall s exceptions list and open TCP IP port 135 1 Check if server and client firewalls allow connections 2 Check if server runs under account that has DCOM rights Update Toolbox server and Toolbox Client to the latest version Update Toolbox server and Page 19 of 21 Lg D Pere supported Unable to bind client ITBNotify callback2. 4 Installation of the Toolbox Client Standalone version of the toolbox can be also used a Toolbox client Please unzip the Toolbox installation package on your local disk and run the StartInstall exe 4 1 Configuration of the Toolbox Client computer 4 1 1 Client Firewall settings Add Toolbox 3 2 application Toolbox 3 2 exe to firewall s exceptions list Add TCP port 135 to firewall exceptions list 4 1 2 Client DCOM configuration 1 Start the DCOMCNFG utility Start Menu gt Control Panel gt Administrative tools gt Component Services or invoke DCOMCNFG from the Start Menu s Run menu item Document Version 1 6 Page 13 of 21 October 2013 QSAR TOOLBOX QSAR Toolbox User Manual Toolbox 3 2 Client Server Configuration 2 Right click on My Computer and select Properties from the popup menu omponent Service 3 lolx D Fie Action view Window Help 181x1 IE EIRE ET COM DCOM Config Distributed Running Applications Transacti Processes 3 Console Root Er Component Services 1 Event viewer Local 8 Services Local 3 Go to COM Security tab and from the Access Permission section use the Edit Default and Edit Limits buttons to change the permissions for security principal Everyone and ANONYMOUS LOGON 4 Check Local Access as well as Remote Access for Security Limits Acc
3. 2 5D preserve stereo information Local Connect Database in use D TBDBs TB3 2_ 14 10 2013 TR sets Abouts FDB Remote Connect Server E Assign Data by SMILES E Use Inventories in chemical input V Pass progress object to server Folder for user models C Users dab Documents QSAR Toolbox QSAR Toolbox 3 0 UserDir Calculations Data format Warning messages P cache a E Do not use parameter List separator Range separator E When define chemical group Memory cache size values calculator v When define chemical group with inventories 5 000 When gather data Count of digits 3 Max count of tautomers for parameter diz when execute query tool calculation and profiling When profiling with metabolism 100 60 Document Version 1 6 Page 16 of 21 October 2013 QSAR TOOLBOX QSAR Toolbox User Manual Toolbox 3 2 Client Server Configuration Connecting to the Toolbox Server After the client side DCOM is properly set up the Toolbox Client application only needs the IP address or name of the Toolbox server 4 2 1 Non Domain client When the Toolbox starts the user is asked to provide credentials for the Toolbox server Select As User and enter username and password of the account who have defined access to the Toolbox Server application on the remote machine for this presentation is the ToolboxSvr Remote Toolbox server 172 17 84 24
4. 8 Server Identity O s current user As User Username Password 4 2 2 Domain Client On the Toolbox remote wizard leave the selection As current user and then click OK the current user will be used to log to the server Document Version 1 6 Page 17 of 21 October 2013 QSAR TOOLBOX QSAR Toolbox User Manual Toolbox 3 2 Client Server Configuration 4 3 Troubleshooting DCOM 4 3 1 Configuration check list Common for domain and non domain configurations DCOM is enabled on both client and the server The Toolbox Server is configured to run in Interactive mode it is possible to define it as user but the user interface will not be accessible The Firewall does not block connections on both client and server On the client the firewall is configured to allow the Toolbox application inbound and outbound connections and TCP IP port 135 is open for outbound connections On the server the firewall is configured to allow ToolboxServer application inbound and outbound connections and TCP IP port 135 is open for outbound connections When in Non Domain configuration There is a defined user account for instance ToolboxSvr on server and client with same name and password The Toolbox account ToolboxSvr is logged into the server Toolbox account has privileges in the DCOM configure section to access launch and activate ToolboxSvr object on both client and the server
5. Help atest I CS NES alent Ema Se cores Root Er Component Services Se a er l te ry COM DCOMConfig Distributed Running Services Local Applications Transacti Processes 3 Go to the DCOM config item on the left hand side tree view right click on the ToolboxServerV32 and select Properties omp a lox GB Sie Action yew window Help a1 cadam eo IO ee B DCOM Config 287 object s amp E My Computer Gi COM Applications 1 3 DCOM Config m Distributed Transaction RDSHost RegSpy Class RegSrve Remote RemoteProx Ronee ee Removable Storage Re Class eS Storage Res sine ScPlugn SecureLogin SecureStora SecureStora SENS Logon SENS Logon SENS Netwerk Events e SENS Onion PS SW Seti SharedAccess SkypeDislog SkypelEPlugin Skypel Plu Events Subscriber Controller 12 SkypeNames2 SkypePNR SmartcardM SMMPECom SonicHTTP SonicLicer SsoProxy recorder stlssvr SyncMan ta_product TdmlconOv TdmNames ThirdPartyE ThirdPartyE ThirdPartyE SyncStatus e ThirdPartyE TimelinePre TintSvr res Tc EF ToolsPlugin ToxTreeToo TPMPlugin Class EKKE a eS ee E Running Processes Gj Event viewer Local By Services Local 4 On the Security tab select Customize and click on the Edit butto
6. The OECD QSAR Toolbox for Grouping Chemicals into Categories User manual Toolbox 3 2 Client Server Configuration QSAR TOOLBOX QSAR Toolbox User Manual Toolbox 3 2 Client Server Configuration Document history Version 1 0 30 10 2010 First version Version 1 1 31 01 2011 Domain controller setup Version 1 2 16 02 2010 Minor update on server side configuration Version 1 3 03 06 2011 Trouble shooting section Version 1 4 05 03 2012 Updated for Toolbox 2 3 Version 1 5 05 10 2012 Updated for Toolbox 3 0 Version 1 6 17 10 2013 Updated for Toolbox 3 2 Issue date October 2013 Language English If you have questions or comments that relate to this document please send them to ehscont oecd org or visit the QSAR Toolbox discussion forum at https community oecd org community toolbox forum Document Version 1 6 Page 2 of 21 October 2013 AR TOOLBOX QSAR Toolbox User Manual Toolbox 3 2 Client Server Configuration Table of Contents 1 Introduction sssssssesenenennnnnenennenenennnnennennnnenenenennnnnennnnenenennnnnnnnnnne 4 2 Prer quisites sseneronsosesnncemnnnetassa en decenasaaecaansrasenens eee nenenenenen unes css ceseues 4 2 1 1 Hardware requirements msnsssnsnsssennnenenenenenenenanananennennnnenenenenenenennnnnnnns 4 2 1 2 Software requirements ss nnnnsnenenenenennananeneenennenenenenenenennnnnnenenenenenenennnnns 4 3 Installation of the Toolbox Server ns
7. Toolbox Server Please unzip the Toolbox Server installation package on your local disk and run the StartInstall exe 3 1 Configuration of the Toolbox Server computer The Toolbox server is a Distributed Component Object Module DCOM automation server In this respect all common rules for the DCOM applications are also valid for the Toolbox server 3 1 1 Server Firewall settings Add Toolbox Server application TBServerV30 exe to the exceptions list Add TCP port 135 to firewall exceptions list 3 1 2 Server DCOM configuration authentication policy Define a single user on the server machine that all client applications then use to authenticate themselves to the server machine s operating system For the purpose of this document this user will be called ToolboxSvr 1 Start DCOMCNFG utility Run a 5 Type the name of a program folder document or Internet resource and Windows will open it for you Open Bi elilexixe e This task will be created with administrative privileges a Cancel Browse Note For the 64bit versions of the Windows please use Start gt Run gt mmc comexp msc 32 to run DCOM configure utility in 32bit mode Document Version 1 6 Page 5 of 21 October 2013 QSAR TOOLBOX QSAR Toolbox User Manual Toolbox 3 2 Client Server Configuration 2 Select properties from the popup menu for My Computer Eile Action View Window
8. Version 1 6 Page 11 of 21 October 2013 QSAR TOOLBOX QSAR Toolbox User Manual Toolbox 3 2 Client Server Configuration 9 Under Default Access Permissions click Edit Default Make sure Distributed COM Users and provide all have Local and Remote Access permissions Default Security Group or user names 2 SELF SYSTEM 2 Acount for Toolbox ToolboxSvr intranet oasis4mc org 82 Administrators INTRANET Administrators Distributed COM Users INTRANET Distributed COM Users Pemnissions for Distributed COM Users Local Access Remote Access Leam about access control and permissions 4 10 Under Default Access Permissions click Edit Limits Make sure Distributed COM Users and provide all have Local and Remote Access permissions 11 Under Default Launch Permissions click Edit Default Make sure Distributed COM User and the user whose authentication credentials will be used to access the COM application all have Local and Remote Launch permissions as well as Local and Remote Activation permissions 12 Under Default Launch Permissions click Edit Limits Make sure Distributed COM Users and the user whose authentication credentials will be used to access the COM Document Version 1 6 Page 12 of 21 October 2013 QSAR TOOLBOX QSAR Toolbox User Manual Toolbox 3 2 Client Server Configuration application all have Local and Remote Launch permissions as well as Local and Remote Activation permissions
9. ess Permission Security Limits Group or user names ER ANONYMOUS LOGON Everyone Add Bemove Permissions for Everyone Allow Deny Local Access Remote Access 5 Check Local Access as well as Remote Access for Default Security Document Version 1 6 Page 14 of 21 October 2013 QSAR TOOLBOX QSAR Toolbox User Manual Toolbox 3 2 Client Server Configuration Access Permission Default Security Group or user names Everyone ER SELF ER SYSTEM Add Remove Permissions for Everyone Allow Deny Local Access Remote Access 4 2 Configuration of the client application The Toolbox standalone application can also act as a Toolbox client application Configuring this requires the Toolbox to have Remote connect set instead of the default Local connection in the Toolbox options When Remote connect is selected for the Database the user needs to specify the name or address of machine where the Toolbox Server is installed After this change Toolbox needs to be restarted When Toolbox is started as client application the database importing features are disabled These functions are delegated to the Toolbox server only Document Version 1 6 October 2013 Page 15 of 21 QSAR TOOLBOX QSAR Toolbox User Manual Toolbox 3 2 Client Server Configuration Structural space mode 2 ignore stereo information
10. interface to the server The server process could not be started because the configured identity is incorrect Check the User name and Password Document Version 1 6 October 2013 TOOLBOX QSAR Toolbox User Manual Toolbox 3 2 Client Server Configuration Server interface of the server differs from the client implementation or the client Client does not allow callbacks from the server The server runs under user account with no defined granted DCOM rights on the client There is no logged user on the server or the logged user does not have granted DCOM rights on the Toolbox Server Toolbox Client to the latest version Grant access launch and activate permissions to the server s user account on the client Option 1 Change the settings of the Toolbox server object from DCOMCNFG to work as user from the identity Option 2 Grant DCOM access launch and activate to the current user logged the system Page 20 of 21 OECD 2 rue Andr Pascal 75775 Paris Cedex 16 France Tel 33 1 45 24 82 00 Fax 33 1 45 24 85 00 ehscont oecd org
11. irtual Virtual Virtual Vista Factory fo Factory f Factory f Factory f Factory f Elevated Volume VssEvent WatAdmin Watson WesPlugin wercplsup Shadow C Service subscrib dil z 5 The interactive user server is started in the session of the current user logged onto the system pros Application is started with user interface cons If there is more than one logged user the server is not able to start The logged user may not have the security rights to activate or access the server The launching user not recommended to use This user server is started in separate session of the specified user Document Version 1 6 Page 7 of 21 October 2013 QSAR TOOLBOX QSAR Toolbox User Manual Toolbox 3 2 Client Server Configuration pros Application always starts cons The user interface is not accessible 3 1 3 Server running domain controller DCOM configuration Domain User who will use the server should be added to the Distributed COM Users group The domain is tested on windows 2008R2 Server From Administrative tools open Active Directory Users and Computers On the right tab select Users In the left tab select user and click on right mouse button On appeared context menu select Add to a group menu item B Active Directory Users and Computers File Action View Help e 9 2m4 0 XE abu mlS a iT aR z Active Directory Users and Comp
12. n for the Launch and Activation Permissions section Add ToolboxSvr to the list and check Allow for Remote Launch and Remote Activation permissions for the user Document Version 1 6 Page 6 of 21 October 2013 QSAR TOOLBOX QSAR Toolbox User Manual Toolbox 3 2 Client Server Configuration 5 On the security tab section select Customize and click on the Edit button for Access Permission section Add ToolboxSvr to the list and check Allow for Remote Activation permission for the user 6 From the Identity tab select The interactive user These are the recommended settings The different Identity settings are explained bellow a Component Services File Action View Window Help s x 28 XO B Console Root 3 3 3 3 3 a Actions a amp Component Services DCOM Co a 5 Computers ThirdPartyE ThirdPartyE Thumbnail timedate cpl fll soe TrayDeskt 4 amp My Computer Cache Out rV32 E COM Applications E DCOM Config 3 3 1 Running Processes Trusted TSTheme TSWbPny UlAutomat UICOM UNS Re i my Distributed Transaction Coo Install exe Class f Event Viewer Local Este Ut updaterAct upnpcont UPnPConta UPnPConta upnphost User exe Notification User Profile Virtual Disk Virtual Disk Virtual Virtual Virtual Service DC Service Service L Factory f Factory f Factory f s l Virtual Virtual V
13. nated administrators 5 Stanislav Temelkov User 5 test acount User Document Version 1 6 Page 8 of 21 October 2013 QSAR TOOLBOX QSAR Toolbox User Manual Toolbox 3 2 Client Server Configuration 4 Enter Distributed COM Users in the edit box and then click on OK button Select Groups 21x Select this object type From this location Enter the object names to select examples Distributed COM Users Check Names sos cms 5 Repeat steps 3 and 4 for all users which have to access the Toolbox server 6 Start DCOMCNFG utility Start gt RUN gt DCOMCNFG Note For the 64 bit versions of the Windows please use Start gt Run gt mmc comexp msc 32 to run DCOM configure utility in 32 bit mode Document Version 1 6 Page 9 of 21 October 2013 QSAR TOOLBOX QSAR Toolbox User Manual Toolbox 3 2 Client Server Configuration 7 Expand Component Services expand Computers and right click My Computer Select Properties File Action View Window Help e9 2m XO ds Hmi J Console Root E Component Services L Computers 18 MMM Refresh all components a com m pcor View gt Runn New Window from Here E cris f Event Viewer Lo Export List E i Services Local Document Version 1 6 Page 10 of 21 October 2013 QSAR TOOLBOX QSAR Toolbox User Manual Toolbox 3 2 Client Server Configuration 8 Click Default COM Security My Computer Properties Document
14. nsnsssssmmemenenenennenenennnenenenennnnnnne 5 3 1 1 Server Firewall settings ms mnnenccnsnnanenennenenenenenenenennnnnnanenenenenennnnnnne 5 3 1 2 Server DCOM configuration smmmmmemememenennanenemnenenenenenenenennnnnnanenenenenenennnnns 5 3 1 3 Server running domain controller DCOM configuration mmmnememememenennss 8 4 Installation of the Toolbox Client nsnsnenensnssnennnnnenenenennenennnnnenennnne 13 4 1 Configuration of the Toolbox Client computer ssmsemmmemmenennnnennuns 13 4 1 1 Client Firewall settings ns nsnencssasananeneennenenenenenennnnnnnenenenenenennnnnnne 13 4 1 2 Client DCOM configuration mnsnsnenencasanananenenenenenenenenennnnnnanenenenenennnnnnne 13 4 2 Configuration of the client application cccsccseeeeeseeneeseeseeeeeseeeeneessenees 15 4 3 Connecting to the Toolbox Server mssnnsnemsanenenenennenenneneenennnnennuns 17 4 3 1 Non Domain client snsnsnssnsnennsnmnemennnnenenennnnnnnnnnennnnnnnnnnnenennnnnnnnnnnnnnnnnnnnne 17 4 3 2 Domain Client nn nnnnssssnsneemnnnenennenennnnnnnnennnnnnnnnnnnnnnnnnnnn en nn nee nnnnnnnnnnnnnnnnnnnne 17 4 4 Troubleshooting DCOM smmsmemamemnanennnnenennennnnenennenennenennenennenennennnn 18 4 4 1 Configuration check list ns nsnsnssssssssssnenneenenenenenenennnmnnenanenenenenennnnne 18 4 4 2 Common errors nn nnnnsnenenanenanennanananannnenenennnnnn anne nn nn nn en en en eme ennnnnnanannnenenennnnnnne 19 Document Ve
15. rsion 1 6 Page 3 of 21 October 2013 QSAR TOOLBOX QSAR Toolbox User Manual Toolbox 3 2 Client Server Configuration 1 Introduction The Toolbox Server is distributed as a Windows MSI package It contains the files comprising the Toolbox Server and a Database to be used by the client Toolbox installations The installation procedure performs only basic COM registration and does not perform any setting up of security permissions policies needed for the working of the server The administrator of the server has the responsibility for configuring the security permissions used for the server s communication 2 Prerequisites 2 1 Hardware requirements The computer hosting Toolbox server must have at least RAM 2 GB recommended 4 GB Hard disk space 12 GB recommended 20 GB CPU Dual core processor 2Ghz or greater 32 or 64 bit architecture recommended quad core CPU Network adapter 100 Mbps recommended 1Gbps 2 2 Software requirements Firebird 2 1 32 bit and 64bit installation Toolbox uses native client library fbclient dll provided within the firebird installation as the Toolbox server as a 32 bit application is able to load only 32 bit client library to access the firebird server To be able to use 64 bit server you should provide 32bit version of fbclient dll Document Version 1 6 Page 4 of 21 October 2013 QSAR TOOLBOX QSAR Toolbox User Manual Toolbox 3 2 Client Server Configuration 3 Installation of the
16. uters Zulu intr yp Descriptio E Saved Queries 3 Acount for Toolbox User this account is intended t E Gj intranet oasis4mc org Administrator User Built in account for admini Builtin 82 Allowed RODC Password Replication Group Security Group Members in this group can E Computers a cert Publishers Security Group Members of this group are ai Denn Controllers amp Denied RODC Password Replication Group Security Group Members in this group can reseed amp DnsAdmins Security Group DNS Administrators Group ee amp DnsUpdateProxy Security Group DNS cients who are permi amp Domain Admins Security Group Designated administrators amp Domain Computers Security Group All workstations and serve amp Domain Controllers Security Group All domain controllers in th amp Domain Guests Security Group All domain guests amp Domain Users Security Group All domain users amp Enterprise Admins Security Group Designated administrators fa Enterprise Read only Domain Controllers Security Group Members of this group are amp Group Policy Creator Owners Security Group Members in this group can LA Guest User Built in account for guest amp RAS and IAS Servers Security Group Servers in this group can amp Read only Domain Controllers Security Group Members of this group are amp Schema Admins Security Group Desig
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