Model 687 Mouse Ventilator User`s Manual
Contents
1. 80 60 50 40 30 20 Tidal Volume ml Ambient Temperature 0 8 0 6 0 4 70 100 200 300 400 600 800 1 2 6 8 10 15 20 30 40 500 400 300 200 150 100 80 60 Breaths per Minute 10 50 40 40 30 20 70 80 90 0 8 0 6 70 100 200 300 400 600 800 1 Grams Ventilation Parameters Mammals with lt 70g Body Mass Body Mass g Vt ml 15 0 1 20 0 12 30 0 18 40 0 24 50 0 30 60 0 36 70 0 42 Publication 5396 001 REV E Tidal Volume Rate BPM 159 148 133 123 117 111 107 10 15 20 Kilograms 0 4 30 40 s Harvard Apparatus Model 687 Mouse Ventilator Operating the Pump Conta Selection of Rate and Volume Refer to the Ventilator Graph above to select the appropriate tidal volume and respiration rate as a function of animal body weight Setting Volume The volume delivered is read by observing the excursion of the O ring on the piston which is closest to the valve block This piston O ring excursion is relative to the volume scale on the outside of the cylinder wall Volume change is accomplished while the Ventilator is running by turning volume knob i2. At its option Harvard Apparatus will repair or replace the unit if it is found to be defective as to workmanship or material This warranty does not extend to damage resulting from misuse neglect or abuse normal wear and tear or accident This warranty extends only to the original customer purchaser IN NO EVENT SHALL HARVARD APPARATUS BE LIABLE FOR INCIDENTAL OR CONSEQUENTIAL DAMAGES Some states do not allow exclusion or limitation of incidental or consequential damages so the above limitation or exclusion may not apply to you THERE ARE NO IMPLIED WARRANTIES OF MERCHANTABILITY OR FIT NESS FOR A PARTICULAR USE OR OF ANY OTHER NATURE Some states do not allow this limitation on an implied warranty so the above limitation may not apply to you If a defect arises within the two year warranty period promptly contact Harvard Apparatus 84 October Hill Road Building 7 Holliston Massachusetts 01746 1371 using our toll free number 1 800 272 2775 Goods will not be accepted for return unless an RMA returned materials authorization number has been issued by our customer service department The customer is responsible for shipping charges Please allow a reasonable period of time for com pletion of repairs replacement and return If the unit is replaced the replacement unit is cov ered only for the remainder of the original warranty period dating from the purchase of the original device This warranty gives you specific right
3. leaving the coupling on the piston shaft Remove the two screws located in the front of the slide valve Remove piston and cylinder Be careful to save the O ring that is recessed in the slide valve block between the screws The O ring provides the airtight seal between the plastic cylinder and the valve block To install the piston and cylinder Ls Pick out the new piston and cylinder Using pliers remove the piston and lubricate with the grease provided Insert the lubricated piston in the cylinder so that the rear of the piston is flush with the rear of the cylinder with the 1 8 diameter coupling stud protruding Install the pinch guard on the cylinder but do not install screws Fasten the cylinder to the valve block with the two screws making sure the O ring is in place Do not tighten these two screws completely but just enough to hold the cylinder in place The object of alignment is to have the stud at the end of the piston be exactly in line with its mating hole in the helical coupling This insures that the piston moves freely within the cylinder without undue friction The two screws at the front of the valve block control left to right alignment while the four screws at the rear of the slide valve control up and down alignment By adjustment of these 6 screws the proper alignment can be made Remember that the screws inter act with one another so the procedure may have to be repeated one or more times When proper
4. of the slide valve Publication 5396 001 REV E 5 Harvard Apparatus Model 687 Mouse Ventilator Changing Piston and Cylinder This Ventilator is furnished with a 1 cc piston and cylinder Note It is extremely important when removing piston and cylinders that they be aligned to be concentric and in line with the piston shaft The cylinder is fastened to the 4 port vertical slide valve by means of two screws located between the room air inlet port and the to animal port on the front of the slide valve The vertical slide valve is fastened to the black 1 4 aluminum sub base by four screws locat ed on the opposite side from the printed label By using these six screws two in front and four on the side alignment adjustments are made see below ALIGNMENT BRACKET VALVE MOUNTING SCREWS CYLINDER MOUNTING SCREWS Publication 5396 001 REV E 3 Harvard Apparatus Model 687 Mouse Ventilator Changing Piston and Cylinder To remove the cylinder and piston I Remove the two screws securing the pinch guard Position the guard to gain access to the helical coupling Set the Ventilator volume to maximum Run Ventilator at lowest speed and stop the Ventilator when the helical coupling is exposed CAUTION A pinch hazard exists when the guard is removed Service should only be performed by trained personnel Using a 0 050 Allen wrench provided disconnect the white piston from the coupling
5. Model 687 Mouse Ventilator User s Manual 687 Mouse Ventilator MAI 55 0001 HARVARD APPARATUS Publication 5396 001 REV E WEEE RoHS Compliance Statement EU Directives WEEE and RoHS To Our Valued Customers We are committed to being a good corporate citizen As part of that commitment we strive to maintain an environmentally conscious manufacturing operation The European Union EU has enacted two Directives the first on product recycling Waste Electrical and Electronic Equipment WEEE and the second limiting the use of certain substances Restriction on the use of Hazardous Substances RoHS Over time these Directives will be implemented in the national laws of each EU Member State Once the final national regulations have been put into place recycling will be offered for our products which are within the scope of the WEEE Directive Products falling under the scope of the WEEE Directive available for sale after August 13 2005 will be identified with a wheelie bin symbol Two Categories of products covered by the WEEE Directive are currently exempt from the RoHS Directive Category 8 medical devices with the exception of implanted or infected products and Category 9 monitoring and control instruments Most of our products fall into either Category 8 or 9 and are currently exempt from the RoHS Directive We will continue to monitor the application of the RoHS Directive to its products and will comply wit
6. alignment is achieved the helical coupling should be connected If align ment is correct the coupling should slide onto the piston stud without bending of the piston rod Install the two screws to secure the pinch guard Publication 5396 001 REV E Repair Kit 13 Repair Instructions for the 687 Respirator F IN 687 VALVE BLOCK O RING 5013 051 1 e tl O RINGS 5013 016 1cc Harvard Apparatus Model 687 Mouse Ventilator Publication 5396 001 REV E Declaration of Conformity Application of Council Directive s 73 23 EEC 89 336 EEC Standard s to which Conformity is Declared Safety EN 61010 1 2 Edition 2001 Emissions Immunity EN 61326 1997 w A1 1998 EN 61000 4 2 1995 EN 61000 4 3 1996 EN 61000 4 4 1995 EN 61000 4 5 1995 EN 61000 4 6 1996 EN 61000 4 11 1994 EN 61000 3 2 2000 w A 14 EN 61000 3 3 1995 w 1997 Manufacturer s Name Harvard Apparatus Manufacturer s Address 84 October Hill Road Holliston Massachusetts 01746 U S A Type of Equipment Mouse Ventilator Model No 687 I the undersigned hereby declare that the equipment specified above conforms to the above Directive s and Standard s Place United States of America Date February 2006 C Signature Beth Bauman HARVARD w VP Engineer
7. d on the rear panel The display will now illuminate The number displayed is the current strokes per minute rate Fuse Replacement Key Information 1 Make sure power cord is disconnected from the main power supply before servicing the fuse 2 Use only Type 3AG 1 4 x 1 1 4 0 75 amp 250 volts Type T time delay fuses Harvard Apparatus part 5153 554 or equivalent Turn off power and remove power cord from power module Use a straight blade screwdriv er to pry open the access door Remove the fuse holder and then remove the fuses from this holder as shown in the figure below Replace fuses using only 0 75 amp 250 volts Type T fuses Then replace the fuse holder Ty Screw Driver Ty LoS A ae re PA Fe i Ly TE gt Fuse T Fuse GD do JN J L El Front View Side View Fuse Holder Detail Note A non operator replaceable fuse exists inside of the equipment This fuse is rated T 40mA 250V 5 x 20mm Publication 5396 001 REV E Harvard Apparatus Model 687 Mouse Ventilator Operating the Pump Connection to the Animal The vertical slide valve has four ports see figure below The top port furthest from the chassis in new orientation is the return channel from the animal which leaves the Pump at the port on the side It is at this top port that expired air can be collected or recyc
8. ed Make Proper Connections Make sure all connections are made properly and securely Orient Equipment Properly Do not position the equipment such that it is difficult to reach the disconnecting device Avoid Pinch Hazard A pinch hazard may exist between the piston shaft coupling and the cylinder Avoid placing fingers between these points while the ventilator is running Observe all Terminal Ratings Review the operating manual to learn the ratings on all connections Use Proper Fuse Use only specified fuses with product Avoid Exposed Circuitry Do not touch any electronic circuitry inside of the product Do Not Operate with Suspected Failures If damage is suspected on or to the product do not operate the product Contact qual ified service personnel to perform inspection Place Product in Proper Environment Review the operating manual for guidelines for proper operating environments Observe all Warning Labels on Product Read all labels on product to ensure proper usage CAUTION Protective Ground Refer to Manual Terminal CAUTION Pinch Hazard Publication 5396 001 REV E Harvard Apparatus Model 687 Mouse Ventilator Specifications 687 Mouse Ventilator Specifications Rate Phase Ratio Dimensions HxLxW Weight Power Stroke Rate Volume Environmental Operating Temperature Operating Humidity Installation Category Pollution Degree Port Part Number Size ID OD Catalog No Accessor
9. h any changes as they apply Do Not Dispose Product with Municipal Waste Special Collection Disposal Required 5 Harvard Apparatus Model 687 Mouse Ventilator Table of Contents SUBJECT PAGE NO General Information Warranty amp Repairs 2 General Safety Summary ccceseeseeeeeeeeeeeeeees 3 Specifications srt 4 Description amp Features cccccccssssessseesssseesseeessseeens 5 Voltage Selection sesiiscceciiecicieicssctiecensssssennanensessccued 6 Fuse Replacement c sssssssecssssenseeesesensseeeseeeeeas 6 Pump Operation Connecting to Animal ooococccnccnccccccccccnnnaanccnnnnnns 7 Selecting Rate amp Volume cceeeeeeeeeeeees 9 Setting Volume amp Rate ooconnnnnncccnncccconccccncnnnnas 9 Using Gas MIU S sete 9 Creating a PEEP csi 9 Cleaning amp Maintenance ccscceeeeeeeeeessenneeees 10 Changing Piston amp Cylinder cccccmmmmmnnnos 11 12 Publication 5396 001 REV E Harvard Apparatus Model 687 Mouse Ventilator General Information Serial Numbers All inquires concerning our product should refer to the serial number of the unit Serial numbers are located on the rear of the chassis Calibrations All electrical apparatus is calibrated at rated voltage and frequency While the flow will stay calibrated the peak will vary Warranty Harvard Apparatus warranties this instrument for a period of one year from date of purchase
10. ies 55 5281 73 3076 Publication 5396 001 REV E Adjustable from 30 to 150 strokes min while the ventilator is running 1 1 fixed 25 x 32 5 x 20 cm 10 x 13 x 8 in 9 5 kg 21lbs 100 120 VAC 200 230 VAC 0 7A 0 35A max 50 60 Hz Continuously variable from 30 to 150 strokes min while the ventilator is running with LIGHT EMITTING DIODE LED DISPLAY Adjustable from 0 05 to 1 ml stroke while the ventilator is running 0 C to 40 C 32 F to 104 F 20 to 80 RH non condensing ll 1 5121 074 1 98 mm 0 078 in 3 17 mm 0 125 in 55 0001 Overhaul Kit for Mouse Ventilator contains O rings valve springs lubricants etc to overhaul Ventilator Connection Kit for Anesthesia Pressurized Gas Connection s Harvard Apparatus Model 687 Mouse Ventilator Description amp Features The MODEL 687 is a positive volume ventilator intended to meet the respiratory require ments of small rodents weighing up to 150 g 0 55 lb A new orientation allows for minimal system dead space and thus more precise tidal volume delivery to the animal This ventilator is furnished with a 1 cc piston cylinder assembly of 0 05 to 1 0 ml breath The mechanical design features a linkage that enables the piston to touch the end of the cylinder at each stroke regardless of the volume This assures that all the air gas mixture taken into the ventilator is expelled at each stroke A positive mechanical slide valve is actuated by a ca
11. ing Operations APPARATUS Position
12. led The middle port is the room air gas channel to the animal e The bottom port closest to the chassis in new orientation is the room air or gas mixture intake Note It is important that the tubes to and from the animal be as short as possible The new orientation allows the animal to be as close as possible to the Ventilator for minimal dead space in the system The actual connection to the animal can be either e Tracheal cannula with y adapter e Intubation cannula with y adapter A selection of trachael cannula and endotracheal tubes are listed in the Harvard Apparartus Catalog and on our website www harvardapparatus com It is important that the volume of tubing shared by inspired and expired air dead space be kept to a minimum by having the Y or T connector as close to the animal as possible f Y Connector E close to animal From Animal ANIMAL Ee gt _ gt ieee P gt Expired Air Tracheal EXHAUST Cannula or Endotracheal TO ANIMAL Tube To Animal E OUT Air Gas Input SIN E Cylinder amp Piston ROOM AIR GV CHASSIS Publication 5396 001 REV E 3 Harvard Apparatus Model 687 Mouse Ventilator Operating the Pump Conta Ventilator Graph Tidal Volume vs Weight amp Rate for Laboratory Mammals in Resting State Apparatus dead space must be added 500 400 300 200 150 100
13. m on the motor to synchronize inspiration and expiration with the motion of the piston Any NON EXPLOSIVE gas air mixture can be used with the ventilator A three way slide valve is attached to the mechanism plate at the end of the cylinder and actuated by a cam on the motor Connection kit 73 3076 is sug gested for this connection THIS VENTILATOR IS NOT TO BE USED IN AN EXPLOSIVE ATMOSPHERE OR WITH ANY EXPLOSIVE GASES SUCH AS ETHER OR CYCLOPROPANE ETC THESE VENTILATORS ARE NOT EXPLOSION PROOF Publication 5396 001 REV E 2 Harvard Apparatus Model 687 Mouse Ventilator Voltage Selection Fuse Replacement Voltage Selection 1 The 687 Ventilator is equipped with a 115 230V selector feature which is incorporat ed into the power entry module located on the side of the unit see figure below The Ventilator is shipped from the factory with the voltage selector set at 115V To change voltage from 115V to 230V follow these steps a Turn off main power and disconnect power cord b Using a small flathead screwdriver pry open the fuse access door on the power entry module see figure below c Remove fuse holder by using the small flathead screwdriver d Rotate the red fuse holder 180 deg and install back into power entry module e Close small access door firmly until fully closed In power entry module window see detail below 230V should be seen f Re install power cord 2 Turn on main power switch locate
14. n the desired direction Setting Rate Adjust the Rate control until the desired rate appears on the LED display Avoid running the Ventilator at rates exceeding 150 breaths min for periods in excess of 2 hours CAUTION Do not over inflate the animal A good rule of thumb is to observe the depth of respiration in the normal calm unanesthetized animal and adjust the volume to approximate this respiration depth when the animal is attached to the Ventilator Use of Gas Mixture It is possible to introduce non explosive air gas mixtures into the lower room air port However the source of gas mixture is usually from a tank delivering gas is at a constant rate while the Ventilator takes in air gas intermittently Some sort of buffer expansion chamber must be provided between the tank and the Ventilator Harvard Apparatus offers a connection kit 73 3076 to depressurize the gas prior to entering the Ventilator This Ventilator is not designed to take air gas inputs under pressure Creating a Positive End Expiratory Pressure PEEP To create a PEEP pressure when using the ventilator simply connect a length of tubing to the Exhaust port and submerge the other end in a column of water There are two locations in which the clip and cylinder can be installed depending on the chosen orientation The depth of the end of the tubing in cm below the water surface will give the PEEP pressure in cmH20 Publication 5396 001 REV E Harva
15. rd Apparatus Model 687 Mouse Ventilator Cleaning amp Maintenance Cleaning To clean the exterior surfaces use a lint free cloth to remove loose dust Use care to avoid scratching the clear display window For more efficient cleaning use a soft cloth dampened with water or an aqueous solution of 75 isopropyl alcohol Maintenance No special maintenance is required other than periodic lubrication of the piston O rings and the slide valve with the special non toxic grease provided To get to the slide valve for lubrication 1 Remove the four screws holding the valve to the 1 4 aluminum black back plate 2 Remove the screws in front that hold the cylinder and valve together 3 Lift entire valve assembly up and out of Ventilator 4 Pull stainless steel valve rod free of valve block 5 Lubricate sparingly Model 687 Rodent Ventilator Replacement Parts Valve Block Assembly 0687 027 Helical 2 Screws Cylinder Coupling 440 X 1 1 8 LG Lec 0687 012 sy 5108 026 5101 165 qq 2 O Ring 1cc 5013 016 I ESPE L ofe y gt J eje P o i Piston Shaft Piston 0687 015 _O Ring Guard Pinch Ice 0687 013 5013 051 0687 019 Lubrication This Model 687 Ventilator is shipped with the appropriate grease to lubricate the piston and O rings in the cylinders and for metal to metal applications such as the inside
16. s and you may also have other rights which vary from state to state Repair Facilities and Parts Harvard Apparatus stocks replacement and repair parts When ordering please describe parts as completely as possible preferably using our part numbers If practical enclose a sample or drawing We offer a complete reconditioning service CAUTION This ventilator is not registered with the FDA and is not for clinical use on human or veteri nary patients It is intended for research use only CAUTION FOR RESEARCH USE ONLY NOT FOR CLINICAL USE ON PATIENTS Publication 5396 001 REV E s Harvard Apparatus Model 687 Mouse Ventilator General Safety Summary Please read the following safety precautions to ensure proper use of your ventilator To avoid potential hazards and product damage use this product only as instructed in this manual If the equipment is used in a manner not specified by the manufacturer the protection provided by the equipment may be impaired To Prevent Hazard or Injury Use Proper Line Cord Use only the specified line cord for this product and make sure line cord is certified for country of use Ground the Product This product is grounded through the grounding conductor of the power cord To avoid electric shock the grounding conductor must be connected to earth ground Before making any connections to the input or output terminals of the product ensure that the product is properly ground
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