Skin Damage Visualizer TiVi60 User Manual
Contents
1. a N Trend Panel displays the actual relative area with erythema red or blanching blue as a bar graph Adapted 100 Max sets the end points of the y axes Skin Damage Visualizer TiVi60 3 2 Sida 252. Click the Zoom Outl button to get back to the original view 15 Click Reset ROI 1 to reset the region of interest marking 16 Click Clear All to clear the Skin Damage Visualizer TiVi60 window from images 4 2 Working with the Library 1 Click the Library button to get to the Library page The Skin Damage Visualizer TiVi60 window should now look like Skin Damage Visualizer TiVi60 3 2 Sida 10 TiVi60 Skin Damage Visualizer Expert Marusl Licence Abat Dero Amistent Mite Cate Threshod Use RON ga sora feterenc Threshold value ter 0 t 1 a 2 Click the Load Photos button to upload images from the library Navigate to the TiVi60demonstration folder and double click the erythema 0001 file All the remaining images named erythema will now be uploaded maximum eight images The Skin Damage Visualizer TiVi60 window should now look like Skin Damage Visualizer TiVi60 3 2 Sida 11 TiVi60 Skin Damage Visualizer bport Monue Licence Abat Demo Assistant liata wary erytters 000 jpg erythers 0602 p3 ary hera t005 pg erytterra W0H pg 19 Sep 2007 11 21 28 15 Sep 2007 1121 31 18 Sep 2007 11 24 16 18 5ep 2007 11 2 13 Thresheid jas 20i as nerta reteremoe Threshol vakse fron to t 3 Print 0 3 in the Threshold edit textbox and click Enter on the computer keyboard After a while the Skin Damage Visualizer TiVi60 window should look like Skin Damage Visualizer TiVi60 3 2 Sida 12 TiVi60 Skin Damage
3. 1 deletes the actual image file in First Image from the folder in which it is stored When the system is in the zoom in mode this button is labeled Save 1 and can be used for saving the zoomed in version of an image Reset ROI 2 deletes a region of interest in Second Image Clear 2 deletes Second Image from the Skin Damage Visualizer TiVi60 window Zoom In 2 displays the region of interest in Second Image if a ROI exists Delete 2 deletes the actual image file in Second Image from the folder in which it is stored When the system is in the zoom in mode this button is hbeled Save 2 and can be used for saving the zoomed in version of an image Display Panel contains radio buttons for displaying photos alone or photos with superimposed erythema blanching areas Load Panel contains buttons for capturing a New image assumes that a camera is connected uploading and displaying the First Image and the Second Image Associated text edit boxes display information about the corresponding file names Threshold includes controls for threshold settings Use ROI or ROI2 as normal reference this checkbox becomes active only if a ROI in either the First or Second Image exist Checking the box makes the system calculate the normal reference value Threshold Level this slider is used to set the actual threshold level If the Use ROT or ROI2 as normal reference checkbox is unchecked the threshold level is set in a
4. Visualizer bport Manusi Licence About Dero Assintent Maat Cras r ibriy erytrerre 20f2 pg aryhers t0li pg 18 Sep 2007 11 21 18 Sep 2007 11 73 13 ergitero 10165 pp 19 Sep 2007 11 25 38 Tireshas Use RDN as nonta reterence Tirestog voue from 0 to 1 4 This sequence of images demonstrates how the red areas corresponding to erythema successively increase in relative size Click the Trend button to display the percentage red area for each of the images in the sequence The Skin Damage Visualizer TiVi60 window should now look like Skin Damage Visualizer TiVi60 3 2 Sida 13 TiVi60 Skin Damage Visualizer Export Manua Licence Abat Demo Asestant ican i Threaton value Pere Oto 1 EE eee 100 Max Maan Page Loorary Leod Partes Tear a 5 The height of the different bars represents the relative skin area with skin irritation erythema in each of the images in the sequence The yaxes automatically adapts to the highest value To display the bars in a 100 full scale mode click the 100 Max button The Skin Damage Visualizer TiVi60 window should now look like Skin Damage Visualizer TiVi60 3 2 Sida 14 TiVi60 Skin Damage Visualizer bport Manuel Licence About Demo Amistent T T T T T 8 amp 8 8B BBB T T l 6 T a Threstow vatie from 0 to 1 6 Click the Clear All button to erase the images and bring the system back to
5. and assumes a value of 100 of the circulation reference value The Skin Damage Visualizer TiVi60 window should look like Skin Damage Visualizer TiVi60 3 2 Sida 17 TiVi60 Skin Damage Visualizer Esport Manual Licence About Derno Assistant Lats Cite First Image Dew 13 0 2007 03 0924 4 13 Oct 2007 OF 15 66 Reset RON Cher 1 Reset ROR Cer 2 F Use RON as normal reterence abovetebw tarmei reference wh shasd 00 1t whtehaed 0002 4 Drag the slider to the right or insert the value 150 in the Edit text box and click Enter on the computer keyboard The Skin Damage Visualizer TiVi60 window should now look like Skin Damage Visualizer TiVi60 3 2 Sida 18 TiVi60 Skin Damage Visualizer Expot Manual Licence About Demo Assistant Haat Donte First Image Dete 12 Oct 2007 49 09 24 Dai 12 Oct 2007 05 15 56 Reset RON Cear 1 Threshatd Ji Uss ROW as nomai reference Threaneid of roteronce rawe whtehand 0901 whiehand 0002 5 All values colored red now represent areas with a concentration of red blood cells erythema more than 150 of those within the reference area 6 Print 75 in the edit text box and click Enter on the computer key board Areas with values below 75 of those in the reference area are now represented by blue color blanching The Skin Damage Visualizer TiVi60 window should now look like Skin Damage Visualizer TiVi60 3 2 Sida 19 TiVi60 Skin Damage Visualizer Gort M
6. more pronounced but hardly visible erythema The difference is however difficult to determine and in particular to quantify by the naked eye 4 To visualize and determine the relative extension of the areas plagued with erythema drag the Threshold slider to the left and or right and note how the extent of the red areas change All areas in the images of the hands with a concentration of red blood cells above the actual threshold level are now colored red Eventually set the Threshold by printing 0 3 in the Threshold edit textbox and click Enter on the computer key board The Skin Damage Visualizer window should now look like Skin Damage Visualizer TiVi60 3 2 Sida 6 TiVi60 Skin Damage Visualizer Esport Manual licence About Demo Assistant 19 Sep 2007 11 2132 1 Sep 2067 113430 Use ROM se namai relerenca Threshot vate femeto 1 arnynarg 0t06 5 The increased extension of the erythema area from the First to the Second Image is now visualized In the Results panel the percentage area of the image of the respective hand colored red is displayed as well as the difference in percentage between the First and the Second Image 6 Click Full View to display only the First Image Skin Damage Visualizer TiVi60 3 2 Sida 7 TiVi60 Skin Damage Visualizer Epot Manual Licence About Demo Assistant Mauls Bais 7 Click the Second Image button the display the Second Image in Full View 8 Click the Main Page to ge
7. the Main page 4 3 Using a Reference Area In many applications the user would like to refer the degree of erythema or blanching to a reference area comprising normal skin circulation By using the features in this section the threshold is set in terms of percentage of reference area to display erythema as values above the threshold value or to display blanching as values below the threshold value 1 Begin with uploading the whitehand 0001 image as the First Image and the whitehand 0002 image as the Second Image The Skin Damage Visualizer TiVi60 window should now look like Skin Damage Visualizer TiVi60 3 2 Sida 15 TiVi60 Skin Damage Visualizer 1 Menust Licence About Demo Assatent iat aie Dee 13 Oct 2007 60 15 56 Threshold value from 0 to 1 whterasd 0001 whestard 0002 2 Mark a region of interest ROD in the First Image that can be considered to represent normal skin microcirculation The Skin Damage Visualizer TiVi60 window could now look like Skin Damage Visualizer TiVi60 3 2 Sida 16 TiVi60 Skin Damage Visualizer f t Manual Likerce Abat Demo Assistant limat Page First Image Dore 1304 2007 0903 24 Reset RON Chart Zeomnt Use ROM sa sorma reference Teresnetd veise fem to t wrdshard 0101 whtehens 0002 3 Check the Use ROI as normal reference to use the selected region as normal skin circulation region The above below normal reference slider now turns red
8. Vi60 3 2 Sida 23 TiVi60 Skin Damage Visualizer Main Page brings the system back to display the Skin Damage Visualizer TiVi60 Main Page window Second Image First Image this button is used to alternatively display the First or the Second Image in the Full View window 5 3 The Library Page Export Monual Licence About Demo Assitont erythems 000 1 pg erytherme 0002 pp erythere 000 pp erytherss 000 p3 19 Sep 2007 11 21 28 19 Sep 2007 11 21 51 19 Sep 2007 11 24 18 19 Sep 2007 1125 13 erytheme 1007 pp 13 Sep 2007 11 45 58 Thresnces Use RON a2 normed reference Threshoti vate fem Dto 1 Trends used for displaying the Trend Page Load Photos used for loading a sequence of images In the Pick a File window select only the first image in the sequence the remaining images up to eight images will be loaded automatically Library Panel displays the uploaded images with superimposed erythema information red or blanching information blue as set by the threshold slider Below each image the actual file name and capturing date amp time are displayed Skin Damage Visualizer TiVi60 3 2 Sida 24 TiVi60 Skin Damage Visualizer 5 4 The Trend Page Export Manuel Licence About Demo Asistant 205 18 5 14 2 42 11 8 z5 1 2 3 5 6 kroge Number Glint Craigs Tread Percentage ct Total Aroa E a in Threshow Use ROI as sorrel reference Thrashoti vate frem 0 to 1
9. a 4 TiVi60 Skin Damage Visualizer 4 HOW TO USE THE SKIN DAMAGE VISUALIZER TiVi60 4 1 Capturing new photos New photos are captured and stored through the TiVi701Camera window Please refer to the TiVi701Camera Manual for further details of the photo capturing process 4 2 Analyzing the images The following section uses the test images named erythema 0001 to erythema 0007 representing a slight skin irritation on the back of the hand These images are stored in the 7iVi6O0demonstration folder 1 Start the Skin Damage Visualizer from nside the TiVi700 Analyzer Click the First button The Pick a File window will now open Navigate to the TiVi60demonstration folder and double click the image file named erythema 0001 The Skin Damage Visualizer window should now look like Osx 15 Sep 2007 11 21 28 Reset RON Gear Skin Damage Visualizer TiVi60 3 2 Sida5 TiVi60 Skin Damage Visualizer 2 Click the Second button and load the file named erythema 0006 stored in the TiVi60demonstration folder The Skin Damage Visualizer window should now look like spot Manual Licence About Demo Assistant Glint Paice Dote 19 Sep 2007 11 21 28 Date W8 Sep 2007 11 34 00 Reset RON Dear i se RON as normi reference Threshold of reference value erytnema 0001 erythers 0006 3 The First Image represents a situation with minor degree of erythema at the back of the hand The Second Image represents the same hand now with
10. and blanching by use of superimposed color schemes Zoom in features to display details of images Marking of anormal skin reference area as a basis for visualization of erythema and blanching Uploading of up to eight images to display consecutive changes in skin microvasculature Integrated trend analysis Export of data to Excel spreadsheet Online manual We are convinced that the Skin Damage Visualizer will be a helpful tool in the assessment and follow up of microvascular disturbances of the hands in a variety of conditions related to occupation medicine Thank you for choosing the WheelsBridge Skin Damage Visualizer TiVi60 WheelsBridge AB Skin Damage Visualizer TiVi60 3 2 Sida 1 TiVi60 Skin Damage Visualizer Information in this document is subject to change without notice and does not represent a commitment on the part of WheelsBridge AB No part of this manual may be reproduced or transmitted in any form or by any means electronically or mechanically including photocopying and recording for any purpose without the express written permission of WheelsBridge AB Any use of application of WheelsBridge products must be performed by properly trained and qualified personnel WheelsBridge AB takes no responsibility for action taken on the basis of information derived from the use of the product described in this manual or from consequential damages in connection with furnishing performance or use of this manua
11. anusi Licence About Demo Assistant Plosti igs Fratimago 13 Oct 2087 05 15 58 F Use RON ss narmal reterence Threstod of refereace valse whtshand 0007 witenans 1002 7 All values colored blue now represent areas with a concentration of red blood cells blanching less than 75 of those within the reference area Skin Damage Visualizer TiVi60 3 2 Sida 20 TiVi60 Skin Damage Visualizer 5 DETAILED DESCRIPTION 5 1 The Main Page Export Manual Licence About Demo Assistant Mint Cine First Image Date 10 Jan 2007 145321 Reset RON Gear 1 Zoom Out Delete 1 Load Use AOH a5 normal reference Threshsid vaise frome to 1 Full View displays the Full View Page Library displays the Library Page Clear All deletes all images from the Main window and resets the system Close closes the Skin Damage Visualizer TiVi60 window Export Menu Allows for export of data to an Excel spread sheet Print Menu for print out of actual window Manual Menu displays on line Skin Damage Visualizer TiVi60 manual Skin Damage Visualizer TiVi60 3 2 Sida 21 TiVi60 Skin Damage Visualizer About displays information about the Skin Damage Visualizer TiVi60 software Reset ROI 1 deletes a region of interest in First Image Clear 1 deletes First Image from the Skin Damage Visualizer TiVi60 window Zoom In 1 displays the region of interest in First Image if a ROI exists Delete
12. bsolute units on as scale from 0 to 1 In this case the slider is displayed in green color If the Use ROTI or ROI2 as normal reference checkbox is checked and the slider is dragged to the right above the 100 reference level the slider is displayed in red color and the photos are displayed with their superimposed erythema areas values above threshold in red color Skin Damage Visualizer TiVi60 3 2 Sida 22 TiVi60 Skin Damage Visualizer If the Use ROI1 or ROI2 as normal reference checkbox is checked and the slider is dragged to the left below the 100 reference level the slider is displayed in blue color and the photos are displayed with their superimposed blanching areas values below threshold in blue color The threshold value can also be set directly by printing the actual value in the text edit box and clicking Enter on the computer key board The threshold level can be set from 0 to 1 in absolute scale green slider or alternatively from 0 to 500 relative to normal reference area red or blue slider depending on if values above threshold erythema or values below threshold blanching are to be displayed Results Panel displays the relative area of erythema or blanching in the First and Second Image if these exist If both exist the Difference of these two quantities is also displayed 5 2 The Full View Page Export Menusi Licence About Demo Asistent Ll als rigs Skin Damage Visualizer Ti
13. l Licensee s limited rights are governed by the license agreement between WheelsBridge AB and MathWorks Licensee may not modify or remove any license agreement file MarthWorks or third party that is included with the MCR Libraries MCR Library License Licensee of this Application accepts the terms of the MCR Library License The Skin Damage Visualizer is patented and or patents are pending in several countries WheelsBridge is a registered trade mark Skin Damage Visualizer TiVi60 3 2 Sida 2 TiVi60 Skin Damage Visualizer 1 INTRODUCTION The Skin Damage Visualizer TiVi60 is a polarization spectroscopy camera software package intended for visualization and assessment of the extension of skin areas plagued with erythema vasodilatation or blanching vasoconstriction in the microcirculation The system is particularly designed for investigation of inflammatory processes in the hands in association with contact dermatitis and for investigation of vasospasm caused by e g vibrating tools The system automatically delivers quantitative data of these parameters thereby making possible observer independent assessment of the progress of a disease process over time or comparison of test results obtained at different work sites Typically images of a hand recorded at different points in time are displayed and compared with respect to the relative extension of the areas affected by erythema and or blanching Alternatively a compa
14. ndence in red blood cell absorption By first separating the colour matrixes and then applying an algorithm in which the value of each picture element in the green colour matrix is subtracted from the corresponding value in the red colour matrix an output matrix representing the local Linearly polarized white light is partly reflected by the upper layer of the skin and partly diffusely scattered in the deeper dermal layers where the microvascular network is located Most of the directly reflected light preserves its state of linear polarization while the light diffusely scattered in the tissue successively becomes randomly polarized The backscattered linearly polarized light directed towards the detector is effectively blocked by a filter with a polarization direction perpendicular to that of the linearly polarized light A portion of the randomly polarized light passes through this filter and reaches the detector This arrangement gives the impression that the camera can see through the top layer of the skin and probe the microcirculation in the deeper dermal layers polarizartion photo red plane alaorithm Skin Damage Visualizer Image red blood cell concentration is generated By applying a threshold based on e g a region of interest including healthy skin the extension and location of areas with values above or below this threshold can be displayed superimposed on the photo Skin Damage Visualizer TiVi60 3 2 Sid
15. pert Menut Lome About Demo Assistant Met Laie First Image Skin Damage Visualizer TiVi60 User Manual User Manual 3 2 Version 3 2 October 2013 PIONEERS IN TISSUE VIABILITY IMAGING TiVi60 Skin Damage Visualizer Dear Valued Customer Welcome to the WheelsBridge Skin Damage Visualizer TiVi60 system designed for automatic analysis of the extent of areas plagued with erythema vasodilatation and blanching vasoconstriction frequently accompanying contact dermatitis and vasospasm caused by use of vibrating tools The Skin Damage Visualizer was designed especially for observer independent automatic analysis of the microcirculation of the hands and is due to its portability well suited for measurements at the work site The Skin Damage Visualizer utilizes a highly sensitive digital camera equipped with polarization filters making it possible to see through the top layer of the skin and probe the microcirculation of the dermal structures The versatile system software based on the MATLAB high performance language for technical computing allows for rapid and easy capturing and analysis of tissue viability images Among the many useful features of the Skin Damage Visualizer software the following are particularly helpful in the evaluation of microvascular disturbances in the hands due to occupational hazards Automatic capturing of a sequence of photos Easy identification of skin areas plagued with erythema
16. rison of the skin microvascular status in the left and right hand can be made An integrated library function allows for comparison of up to eight images simultaneously Based on the information of these images the trend of the erythema blanching process is determined The intended use of the Skin Damage Visualizer TiVi60 is to investigate the extent of skin damage in occupational health research applications It is not yet approved for the diagnosis and treatment of disease 2 THE SKIN DAMAGE VISUALIZER TiVi60 The Skin Damage Visualizer comprises a camera mounted to a flexible table mounted stand during image capturing a portable computer and a software package for image processing and data presentation All interaction with the Skin Damage Visualizer is made through the computer keyboard The system is truly portable and can easily be moved from one workplace to another thereby facilitating investigations at the work site Skin Damage Visualizer TiVi60 3 2 Sida 3 TiVi60 Skin Damage Visualizer 3 OPERATING PRINCIPLES flash detector filter polarized light The green component of the light reaching the detector is attenuated due to a high absorption in red blood cells while the red component is virtually unaltered because of its low absorption in the red blood cells Surrounding tissue absorbs green and red light to approximately the same amount The Skin Damage Visualizer takes advantage of this wavelength depe
17. t back to the Skin Damage Visualizer main page 9 Click the Photo radio button in the Display panel to view the images only 10 Mark a region of interest ROD in the First Image by use of the mouse point to the upper left corner of where the ROI should start hold the left mouse button down and drag the pointer to the lower right corner of the ROI and release the left mouse button Click the Erythema radio button The Skin Damage Visualizer TiVi60 window should now look like Skin Damage Visualizer TiVi60 3 2 Sida 8 TiVi60 Skin Damage Visualizer Date 19 Sep 2007 11 21 22 Oaa 19 Sep 2007 11 14 30 Reset RON Clear 1 Reset ROQ Gear Zomi Z Tiresho Use ROI as sorrel refererce Threshot value tom 0 to 1 a eryinares 001 eryitersa 8006 11 Click the Zoom In 1 button The Skin Damage Visualizer TiVi60 window should now look like Skin Damage Visualizer TiVi60 3 2 Sida 9 TiVi60 Skin Damage Visualizer teport Memali tiewe About Demo Acastant Mans Cage First Image Threshold value term 0 9 1 eryttere f00 tage First Second Difference 65 s Ciesr All Orcas arytterra L006 12 Click the Save1 button to store the zoomed in image In the Save As window select a folder and give the zoomed image a name Click Save to store the image 13 Click Full View to display the zoomed in image in full view Click the Main Page button to get back to the Skin Damage Visualizer TiVi60 main page 14
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