Varian 705 DS 70-9041 Rev B
Contents
1. Step 1 Toggle the printer off line by pressing the printer toggle switch to the OnLine Off Line position When the printer is off line the Ready LED does not illuminate Step 2 Grasp the paper roll cover firmly by the grooves on the side and the front edge Pull outward to remove the cover Step 3 Press the printer toggle switch to Paper feed to advance the paper approximately one inch beyond the paper cutter Step 4 Using scissors cut the paper feeding to the printer and remove the paper roll Step 5 Pull the remaining paper through the printer mechanism Pull the paper from the front paper cutter side Pulling the paper out of the back of the printer will damage the print mechanism Step 6 Unroll several inches of paper on the new roll Step 7 If it is jagged cut a straight edge on the paper roll to facilitate the entry of the paper into the printer Step 8 Slide the paper through the slot connecting the paper compartment and the printer compartment You can slide it in approximately 1 4 inch before it stops Varian Inc Page 46 Varian 705 DS Dissolution Revision B 01 06 Maintenance and Troubleshooting Apparatus Operator s Manual P N 70 9041 Step 9 While holding the paper in place press the printer toggle switch to the Paper feed position and hold until approximately one inch of paper has emerged from the top of the printer Make sure the roll of paper feeds squarely If it does not the paper will ja2. Step 1 Toggle the printer off line by pressing the printer toggle switch to the OnLine Off Line position When the printer is off line the Ready LED does not illuminate Step 2 Four small grooves are embossed on the printer cover Gently push on these grooves to tilt the cover When the printer cover is tilted up you can lift it off completely Step 3 Push down on the right side of the ribbon cartridge marked PUSH and remove the old cartridge Step 4 Install the new cartridge If there is already paper in the printer hold the cartridge between your thumb and index finger slide it over the paper and into the printer compartment Ensure the paper is between the ribbon cartridge and the ink ribbon Ensure the ink cartridge is inserted firmly to prevent weak or irregular printing The cartridge must be properly seated and aligned for the best printing Step 5 Turn the cartridge knob marked by an arrow clockwise to stretch the ribbon taut Step 6 Replace the cover Varian Inc Revision B 01 06 Varian 705 DS Dissolution Page 45 P N 70 9041 Apparatus Operator s Manual Maintenance and Troubleshooting Step 7 Toggle the printer online by pressing the printer toggle switch to the OnLine Off Line position The Ready LED illuminates Step 8 Replace the paper if necessary If you get ribbon ink on the printer s plastic cover remove it immediately Once dried it is difficult to remove Replacing the Paper Roll
3. Step 2 Use the plus and minus arrows to increment or decrement the entry Step 3 If a remote device will be used to operate the apparatus ensure autolock is enabled Note A remote command can activate the keypad lock only if the _K gt autolock is enabled The touchscreen automatically unlocks at the test completion Once locked no user input other than acknowledging an alarm is accepted Step 4 Press OK Varian Inc Revision B 01 06 Varian 705 DS Dissolution Page 31 P N 70 9041 Apparatus Operator s Manual Setting Up Filling the Water Bath Step 1 Remove one vessel and set it aside Pour ultrapure water through the hole in the vessel plate Fill the water bath 3 4 full to allow for displacement by the vessels refer to the sticker on the water bath for the appropriate fill level You can also fill through the bottom drain valve if you have a pressurized ultrapure water hose Note If possible preheat the water to speed achievement of the desired water bath temperature Use ultrapure water whenever possible to minimize scale and mineral buildup Algaecides may be used to inhibit algae and bacteria growth Check the label to ensure the formulation is compatible with the plastic materials used to construct the water bath See Water Bath Care on page 41 Step 2 Turn on the heater circulator Step 3 Check all connections for leaks Bubbles may appear at the w
4. 36 0 1412 65 0 469 00 8 0 4937 37 0 1355 66 0 452 90 9 0 4703 67 0 437 40 10 0 4482 68 0 422 50 11 0 4273 69 0 408 20 12 0 4074 70 0 394 50 13 0 3886 71 0 381 20 14 0 3708 72 0 368 50 15 0 3539 73 0 356 20 16 0 3378 74 0 344 50 17 0 3226 75 0 333 10 18 0 3081 76 0 322 30 19 0 2944 48 0 875 80 77 0 311 80 20 0 2814 49 0 842 80 78 0 301 70 21 0 2690 50 0 811 30 79 0 292 00 22 0 2572 51 0 781 10 80 0 282 70 23 0 2460 52 0 752 20 Varian Inc Revision B 01 06 P N 70 9041 Varian 705 DS Dissolution Page 51 Apparatus Operator s Manual Maintenance and Troubleshooting Fuse Replacement A Warning The dissolution apparatus contains electrical circuits devices and components operating at dangerous voltages Contact with these circuits devices and components can cause death serious injury or painful electric shock Panels or covers that are retained by fasteners which require the use of a tool for removal may be opened only by Varian trained Varian qualified or Varian authorized service engineers The fuse holder is located in the lower section of the power entry module on the rear of the dissolution apparatus Step 1 Step 2 Step 3 Step 4 Step 5 Step 6 Before checking or attempting to replace a fuse turn the instrument off and remove the power cord from the dissolution apparatus There are two release slots one on the left and one on the right The fuse holder is released
5. B 01 06 Maintenance and Troubleshooting Apparatus Operator s Manual P N 70 9041 Step 5 The printer toggle switch is used to complete the configuration Pressing the left side of the printer toggle switch selects NEXT to advance to the next menu item Pressing the right side of the printer toggle switch selects OK to accept what is stated on this line of the menu item Each time the switch is pressed another part of the menu prints Allow the printer to finish printing before pressing the switch again See the table of commands below al Ta Note The printout is easier to read if the printer cover is removed SETUP MENU CONFIGURE NEXT OK Press NEXT to avoid configuration CUSTOM NEXT OK Press OK to enter custom mode CUSTOM MENU PRINT CUSTOM SETUP NEXT OK Press NEXT AUTO SEQ NO NEXT OK Press OK ZERO NEXT OK Press OK POUND SIGN NEXT OK Press OK _ UNDERSCORE NEXT OK Press OK ONLINE OFFLINE YES NEXT OK Press OK EXT CH SET NO NEXT OK Press OK PRINT READY YES NEXT OK Press NEXT PRINT READY NO NEXT OK Press OK READY Your printer is now configured correctly Varian Inc Revision B 01 06 Varian 705 DS Dissolution Page 49 P N 70 9041 Apparatus Operator s Manual Maintenance and Troubleshooting Water Bath Temperature Probe Accuracy Test The temperature probe can be tested using a high quality voltmeter capable of at least four
6. Warranty Service 56 Warranty Limitations 56 Exclusive Remedies 57 Index 59 Tell Us How We Are Doing 61 Varian Inc Table of Contents This page was intentionally left blank except for this message Varian Inc chapter1 Safety Practices and Hazards The Varian 705 DS Dissolution Apparatus has been carefully designed so that when used properly you have an accurate fast flexible and safe instrument If the equipment is used in a manner not specified by the manufacturer the protection provided by the equipment may be impaired Operation of a Varian 705 DS Dissolution Apparatus involves the use of aqueous liquids and various pharmaceutical dosage forms Unskilled improper or careless use of this instrument can create shock hazards fire hazards or other hazards which can cause death serious injury to personnel or severe damage to equipment and property Information on safety practices is provided with your instrument and operation manuals Before using your instrument or accessories you must thoroughly read these safety practices Observe all relevant safety practices at all times Varian Inc Page 8 Varian 705 DS Dissolution Revision B 01 06 Safety Practices and Hazards Apparatus Operator s Manual P N 70 9041 Electrical Hazards The dissolution apparatus contains electrical circuits devices and components operating at dangerous voltages Contact with these circuits devices and compon
7. and basket shafts cannulas and temperature probes are particularly susceptible to surface corrosion if not cleaned Varian Inc Page 38 Varian 705 DS Dissolution Revision B 01 06 Maintenance and Troubleshooting Apparatus Operator s Manual P N 70 9041 thoroughly after use If any stainless steel parts show signs of surface discoloration lightly wipe the surface with a soft cloth or nonabrasive pad to remove it e Carefully wipe the paddles or basket shafts after each use e Carefully wash the dissolution baskets after each use e Carefully wash the dissolution vessels after each use Caution Use care when washing the TruCenter vessels as heat over 65 C can damage the plastic of the magnetic ring flanges Weekly Maintenance See Paddle Basket Shaft Care on page 39 Basket Care on page 40 and Water Bath Care on page 41 as applicable for additional information on proper maintenance of your equipment e Inspect the water bath and heater circulator tubing for algae or other materials If algae is present change the bath water and add an algaecide If you use a water bath algaecide or clear bath product ensure it is compatible with PETG and acrylic Monthly Maintenance See Paddle Basket Shaft Care on page 39 Basket Care on page 40 and Water Bath Care on page 41 as applicable for additional information on proper maintenance of your equipment e Drain the water from the
8. by inserting a small screwdriver into one of the slots However two screwdrivers one in each slot may work best A slight application of pressure toward the center of the compartment releases the fuse holder Pull the fuse holder out of the power entry module The fuse is located in the removable holder The fuse for the 230 V apparatus is a 2 amp metric 5 mm x 20 mm fuse and for the 115 V apparatus is a 3 amp metric 5 mm x 20 mm fuse Place the new fuse into the holder and insert the fuse holder into the power entry module The holder is keyed and can be inserted only one way Push the fuse holder into the power entry module until both sides snap Replace the power cord Varian Inc Page 52 Varian 705 DS Dissolution Revision B 01 06 Maintenance and Troubleshooting Apparatus Operator s Manual P N 70 9041 Troubleshooting The Dissolution Systems Service Department can assist you if you experience problems or have questions concerning your dissolution apparatus Many problems can be traced to simple sources and are easily solved Following is a troubleshooting guide which may help you The Dissolution Systems Service Department can be reached at 800 229 1108 inside the US or 919 677 1108 outside the US Optionally you can send a fax to 919 677 1138 You can also e mail the Dissolution Systems Service Department at dissolution service varianinc com Problem Possible
9. digit resolution and a water bath of known temperature Both the multi meter and the bath temperature probe or calibrated thermometer must be traceable to a known reference standard such as NIST Step 1 Place the probe into a known temperature water bath and allow several minutes for the probe to equilibrate Step 2 The resistance is measured by attaching the leads of the multi meter to the top and shank of the 1 4 inch phone plug Step 3 Refer to the following table to find the resistance value of the probe at the known bath temperature Temperatures between the values listed may be interpolated Step 4 Probes are interchangeable and manufactured with a tolerance of 0 2 C Probes found to be outside the tolerance of 0 2 C should be replaced Varian Inc Page 50 Varian 705 DS Dissolution Revision B 01 06 Maintenance and Troubleshooting Apparatus Operator s Manual P N 70 9041 Temp Resistance Temp Resistance Temp Resistance C Ohms C Ohms C Ohms 5 0 9530 24 0 2354 53 0 724 50 4 0 9046 25 0 2252 54 0 697 90 3 0 8586 26 0 2156 55 0 672 50 2 0 8151 27 0 2064 56 0 648 10 1 0 7741 28 0 1977 57 0 624 80 0 0 7355 29 0 1894 58 0 602 40 1 0 6989 30 0 1815 59 0 580 90 2 0 6644 31 0 1739 60 0 560 30 3 0 6319 32 0 1667 61 0 540 50 4 0 6011 33 0 1599 62 0 521 50 5 0 5719 34 0 1533 63 0 503 30 6 0 5444 35 0 1471 64 0 485 80 7 0 5183
10. the 705 DS and turn it back on Note if the VK 8000 is interrupted before the end of a test the stop command may never be sent The spindles do not turn Spin disable is active Enable spin enable The drive unit is raised Lower the drive unit to the proper operating position The vessel temperatures do not display The probe is reading the water bath temperature instead of the vessel temperature Press the temperature display to display the vessel temperature Varian Inc Page 54 Varian 705 DS Dissolution Revision B 01 06 Maintenance and Troubleshooting Apparatus Operator s Manual P N 70 9041 This page was intentionally left blank except for this message Varian Inc Chapter 6 Service and Warranty The warranty is provided by Varian Inc or one of its authorized representatives Service and Warranty Information Varian dissolution products carry a one year warranty on parts and labor The Dissolution Systems Service Department or one of its representatives will at its option either repair or replace any mechanical and electrical components in your instrument which prove to be defective During the first year of warranty coverage there is no charge for the labor to repair your unit The Dissolution Systems Service Department or one of its representatives will determine the best site to repair the unit either onsite or returned to Varian Inc Any onsite
11. the front and rear center of the unit as well as the left and right sides The bottoms of the legs have adjustable rubber feet These may be screwed in or out to raise or lower each leg Adjust the feet so the bubble inside the level is within the circle at all four points Varian Inc Revision B 01 06 Varian 705 DS Dissolution Page 19 P N 70 9041 Apparatus Operator s Manual Setting Up Electrical Connections Warning Ensure the apparatus is configured for the voltage available in your laboratory Check the serial number tag on the rear panel of the instrument to confirm the voltage requirement The electrical connection at the back of the apparatus is the primary disconnect for the instrument Step 1 Verify the Varian 705 DS Dissolution Apparatus is off Step 2 Connect the power cord between the receptacle on the drive unit rear panel and an outlet of the appropriate voltage Step 3 Connect the power cord between the receptacle on the heater circulator and an outlet of the appropriate voltage Connecting the Heater Circulator Caution Connect the heater circulator to the water bath and ensure the drain valve is in the closed position Fill the water bath before turning on the heater circulator to avoid damaging the heating elements Step 1 Place the heater circulator under the rear of the vessel plate with the power switch to the right of the unit and the power outlet to the re
12. touchscreen press Cal The Screen Settings screen displays Follow the onscreen instructions Note see If the screen calibration is inaccurate or off balance so that the U gt touchscreen does not respond turn off the apparatus and tap the POST screen prior to the completion of the test The Screen Settings screen displays Follow the onscreen instructions Setting the Clock Step 1 Press Clock The following screen displays 08 15 20 A cancel 12 23 2004 dS Ac Format _ Step 2 Press Format to change the date format to one of the following options MM DD YYYY DD MM YYYY and YYYY MM DD Note ee eee If a date format has previously been selected that format I gt displays in place of the format button Press the indicated format to change the format The options scroll each time the screen in pressed Step 3 Use the left and right arrows to move the cursor between the hours component the minutes component the seconds component as well as the month component the day component and the year component Step 4 Use the plus and minus arrows to increment or decrement the entries and press OK Varian Inc Page 30 Varian 705 DS Dissolution Revision B 01 06 Setting Up Apparatus Operator s Manual P N 70 9041 Setting the Communication Port Identification Number Step 1 Press Com Port One of the following screen displays Cancel Cancel autolock enabled autolock disabled
13. warranty services are provided only at the initial installation point Installation and onsite warranty services are available only in Dissolution Systems service travel areas Varian Inc Page 56 Varian 705 DS Dissolution Revision B 01 06 Service and Warranty Apparatus Operator s Manual P N 70 9041 Exclusions and Limitations Excluded from this warranty are expendable or consumable items such as but not limited to paddles baskets vessels and acrylic water baths Also excluded are defects from improper or inadequate maintenance by the customer user induced chemical action or contamination unauthorized modification or misuse and improper site preparation and maintenance Operation of software is not warranted to be uninterrupted or error free Obtaining Warranty Service To obtain warranty service in the United States contact the Dissolution Systems Service Department at 800 229 1108 to obtain authorization to return units for repair At the option of the customer onsite warranty service is available but travel charges may be incurred The customer should prepay all shipping charges for products returned to the Dissolution Systems Service Department unless otherwise authorized and Varian Inc will pay all charges for return to the customer Warranty Limitations Varian Inc makes no other warranty either express or implied with respect to this product Specifically disclaimed are any implied warranties of merchan
14. Cause Suggested Solution The unit does not There is a blown fuse in the Replace if necessary See respond when main rear panel AC line cord Fuse Replacement on power is ON receptacle page 51 The unit is not plugged into a Plug the unit into an power outlet appropriate power outlet The electrical outlet does not Check the outlet for electrical have power current The spindles are not The drive belt is loose Tighten the drive belt synchronized The printer does not The printer is offline Ensure the printer is online and print enabled The printer frequency is set to Set the correct printer 0 frequency The printer is out of paper Ensure paper is installed in the printer The water bath will not The heater circulator is not Ensure the heater circulator is heat powered on powered on The temperature probe is notin Place the temperature probe in the water bath the water bath The water bath temperature is Set the correct water bath set incorrectly temperature Varian Inc Revision B 01 06 Varian 705 DS Dissolution Page 53 P N 70 9041 Apparatus Operator s Manual Maintenance and Troubleshooting Problem Possible Cause Suggested Solution The keypad does not respond to user input The apparatus is in autolock mode The padlock displays locked on the screen The 705 DS screen is locked until the VK 8000 sends the command to stop the paddles If the screen does not unlock at that point turn off
15. M 37 4 C vessel o00 00 00 0912 2004 12 42 34 a 00 00 09 12 2004 12 42 34 eal oo ara A Note u_ If the POST fails an alarm sounds and FAIL displays next to the appropriate test Press OK to acknowledge the fault condition silence the alarm and continue to the main screen Preliminary Functions Prior to using the Varian 705 DS Dissolution Apparatus it may be necessary to set the clock or communication port identification number adjust the brightness or contrast of the LED screen or calibrate the touchscreen These functions are available from the second system menu screen Varian Inc Page 28 Varian 705 DS Dissolution Revision B 01 06 Setting Up Apparatus Operator s Manual P N 70 9041 From the status screen press Menu The system menu screen displays Bath m oun Press More The following screen displays Once complete press Esc twice from any of the secondary screens listed below to return to the status screen Setting the Screen Contrast and Brightness Step 1 Press Screen The following screen displays Step 2 Use the plus and minus arrows on the left side to adjust the screen contrast Step 3 Use the plus and minus arrows on the right side to adjust the screen brightness Varian Inc Page 29 Revision B 01 06 Varian 705 DS Dissolution Setting Up P N 70 9041 Apparatus Operator s Manual Calibrating the Touchscreen To recalibrate the
16. ap AK VARIAN Varian 705 DS Dissolution Apparatus Operator s Manual P N 70 9041 January 2006 Revision B Limitation of Liability The information in this document is subject to change without notice Varian Inc makes no warranty of any kind with regard to this material including but not limited to the implied warranties or merchantability and fitness for a particular purpose Varian Inc shall not be liable for errors contained herein or for incidental consequential damages in connection with the furnishing performance or use of this material All rights are reserved Reproduction adaptation or translation without prior written permission is prohibited except as allowed under copyright laws First Edition January 2006 Varian 705 DS Dissolution Apparatus Operator s Manual Part Number 70 9041 Revision B Printed in the United States of America The following terms are trademarks of Varian Inc TM Practical Solutions e Benchsaver BIO DIS III QA and QAII e Enhancer Cell e TruCenter Full Flow Filters VanKel e Peak Vessel VKE All other trademarks are the property of their respective owners Varian Inc 13000 Weston Parkway Cary North Carolina 27513 2250 800 229 1108 919 677 1108 Fax 919 677 1138 www varianinc com ap CN VARIAN Copyright c 2005 2006 by Varian Inc Table of Contents Chapter 1 Safety Practices and Hazards 7 Electrical Hazard
17. ar The two front feet of the heater circulator should be placed into the two large holes in the apparatus s bottom center brace To reduce possible influence of vibration ensure the heater circulator is not touching the apparatus Varian Inc Page 20 Varian 705 DS Dissolution Revision B 01 06 Setting Up Apparatus Operator s Manual P N 70 9041 Step 2 Locate the two pieces of plastic tubing and the four tubing clamps included in the heater circulator kit Step 3 Place one end of the plastic tubing over the barbed 90 degree angle adapter located to the right of the water bath This is the water bath inlet Step 4 Slide one of the tubing clamps over the free end of the tubing and slide it over the barbed angle adapter Secure the tubing clamp Caution Do not over tighten the tubing clamps Damage to the plastic tubing could result Step 5 Slide another clamp over the free end of the tubing and attach the free end to the supply inlet located on the right side of the heater circulator Secure the tubing clamp Step 6 Place one end of the other piece of plastic tubing over the barbed 90 degree angle adapter located to the left of the water bath This is the water bath outlet Step 7 Slide one of the stainless steel clamps over the free end of the tubing and over the barbed angle adapter Secure the tubing clamp Step 8 Slide the last clamp over the free end of the tubing and attach the free end to
18. ater bath inlet as the air in the system is purged After a few minutes flow into the water bath should be smooth and steady Note A Though the heater circulator is designed to be self priming it In might be necessary to help the priming process in a dry unit To help clear the air hold the unit below the level of the water bath for a minute or two with the left end up Varian Inc Page 32 Varian 705 DS Dissolution Revision B 01 06 Setting Up Apparatus Operator s Manual P N 70 9041 This page was intentionally left blank except for this message Varian Inc chapter4 Operating and Programming Warning This is a rotating apparatus Keep hair and loose clothing away from the spindles System Status The system status displays on the main screen Pen Caer ee 000 00 00 09 12 2004 12 42 34 ta 000 00 00 09 12 2004 12 42 34 ia Varian Inc Page 34 Varian 705 DS Dissolution Revision B 01 06 Operating and Programming Apparatus Operator s Manual P N 70 9041 Following is a description of the main screen options Options Function Menu Use this option to set the system parameters Press Menu The system menu screen displays See System Menu on page 35 Bath Vessel The Bath Vessel button toggles between the options Use this option to toggle between displaying the water bath temperature and the vessel temperature When the butto
19. d centering the vessels 21 installing receptor shafts 22 installing the printer cartridge ribbon 44 introduction 13 l leaking fittings repairing 42 limitations 56 m maintenance 37 monthly maintenance 38 o obtaining warranty service 56 p paddle care 39 paddle height setting 23 periodic maintenance 37 printer configuration 47 self test 47 toggling online 46 Varian Inc Index r reader comment form 61 receptor shafts installing 22 removing paddles or baskets shafts 24 repairing leaking fittings 42 s safety practices 7 self test printer 47 service 55 setting basket height 23 setting paddle height 23 setting the clock 29 setting up the dissolution apparatus 17 t troubleshooting 52 u unpacking your equipment 17 usp physical parameters 16 usp Suitability test 16 v vessels installing and centering 21 w warranty 55 warranty limitations 56 water bath care 41 water bath temperature probe accuracy test 49 water bath filling 31 weekly maintenance 38 Varian Inc Tell Us How We Are Doing We listen to our customers We work hard to make our technical documentation user friendly and to make the information in our manuals easy to retrieve and use We d like you to tell us the kinds of additional information you d find helpful in our documentation Your feedback will be carefully considered when we prepare future editions of this manual This manual should contain
20. d the value RPM Press RPM to set the RPM Use the plus and minus buttons to increment or decrement the entry Press OK to save the RPM Press Cancel to discard the value Test Duration Press Test Duration to set the length of time for which the test runs before automatically stopping Use the right and left arrows to move the cursor among the components Use the plus and minus to increment or decrement the entry Press OK to save the test duration Press Cancel to discard the value Varian Inc Page 36 Varian 705 DS Dissolution Revision B 01 06 Operating and Programming Apparatus Operator s Manual P N 70 9041 Options Function Printer Press Printer to enable or disable the printer and control the automated print frequency The Printer Settings screen displays Press Print Frequency to enter the desired intervals at which the system status prints Use the left and right arrows to move the cursor between the hours component and the minutes component Use the plus and minus buttons to increment or decrement the entry Press OK to save the print frequency Press Cancel to discard the value If the printer is disabled Enable displays Press Enable to enable the printer and Disable displays More Press More to access additional system settings The secondary system menu screen displays See System Menu 2 below System Menu 2 Following is a description of the secondary system
21. e use of a tool for removal may be opened only by Varian trained Varian qualified or Varian authorized service engineers Step 1 Raise the drive unit to approximately full height Step 2 Turn off power to the instrument and remove the power cord Step 3 The top cover is attached with seven screws on the top and six screws on the bottom of the drive unit Step 4 Remove the Phillips head screws Step 5 Lift the top cover and secure it to the underside of the top plate with clamps Step 6 Inspect the drive belt for unusual wear fraying and tension Step 7 a the clamps securing the top cover to the underside of the top plate Step 8 Replace the top cover Step 9 Replace the Phillips head screws Step 10 Reconnect the power cord and turn on the instrument Varian Inc Page 44 Varian 705 DS Dissolution Revision B 01 06 Maintenance and Troubleshooting Apparatus Operator s Manual P N 70 9041 Report Center Impact Printer The following is helpful information for using your impact printer Installing the Cartridge Ribbon If the printer is used infrequently the print impression sometimes becomes weak because the ribbon dries out If the printed material is difficult to read and you suspect this is the cause of the problem advance to a new section of the ribbon by pressing the printer toggle switch to the Paper feed position If the printing is still faint replace the cartridge To install the cartridge
22. e but are not limited to the following e Hot water lt 150 F Vinegar 5 Glacial Acetic Acid Ethyl alcohol maximum 10 Isopropyl alcohol maximum 25 Varian Inc Page 42 Varian 705 DS Dissolution Revision B 01 06 Maintenance and Troubleshooting Apparatus Operator s Manual P N 70 9041 Repairing Leaking Fittings Complete these steps if any of your water bath fittings are leaking Step 1 Step 2 Step 3 Step 4 Step 5 Step 6 Step 7 Step 8 Step 9 Step 10 Turn off the heater circulator and drain the water bath completely Remove the leaky bulkhead fitting Remove the elbow fitting from the bulkhead fitting Inspect the bulkhead fitting gaskets for damage and replace them as necessary Remove the old Teflon tape from all male fittings Inspect the threads for damage and replace the fitting as necessary Apply new Teflon tape to the male fitting threads Reinstall and tighten the bulkhead fitting on the water bath Reinstall and tighten the elbow fitting to the bulkhead fitting Fill the water bath and turn on the heater circulator Inspect the fitting for leaks If the fitting still leaks contact the Dissolution Systems Service Department Varian Inc Revision B 01 06 Varian 705 DS Dissolution Page 43 P N 70 9041 Apparatus Operator s Manual Maintenance and Troubleshooting Visual Checks Caution Panels or covers that are retained by fasteners which require th
23. e for North America Indicates that this product must not be disposed of as unsorted municipal waste see WEEE Directive on page 11 General CE Compliant Products The Varian 705 DS Dissolution Apparatus has been designed to comply with the requirements of the Electro magnetic Compatibility EMC Directive and the Low Voltage Directive LVD of the EU Varian Inc has confirmed that each product complies with the relevant directives by testing a prototype against the prescribed European Norm EN standards Varian Inc Revision B 01 06 Varian 705 DS Dissolution Page 11 P N 70 9041 Apparatus Operator s Manual Safety Practices and Hazards Proof that a product complies with the directives is indicated by e the CE marking appearing on the rear of the product e the documentation package that accompanies the product containing a copy of the declaration of conformity This declaration is the legal declaration by Varian Inc that the product complies with the directives and also shows the EN standards to which the product was tested to demonstrate compliance The declaration of conformity is signed by the representative of the manufacturing plant cTUVus U S and Canadian Product Approvals The Varian 705 DS Dissolution Apparatus has been designed to comply with North American safety requirements This product has been tested and certified for the North American market by TUV Rheinland of North America Inc The TUVu
24. el in this position indicating the vessel is centered Step 5 Lift the gauge and rotate it 90 degrees Step 6 Repeat steps 3 5 fitting the gauge in the remaining two slots on the EaseAlign centering ring Varian Inc Page 26 Varian 705 DS Dissolution Revision B 01 06 Setting Up Apparatus Operator s Manual P N 70 9041 Printer Setup The printer can be placed in any convenient location near the Varian 705 DS Dissolution Apparatus Follow these steps to connect the printer Step 1 Connect one end of the parallel printer cable to the printer and the other end into the position marked PRINTER on the rear of the Varian 705 DS Dissolution Apparatus Step 2 Plug the power supply into a properly grounded power outlet and the cord into the power connection in the rear of the printer FIGURE 4 Printer Varian Inc Page 27 Revision B 01 06 Varian 705 DS Dissolution Setting Up P N 70 9041 Apparatus Operator s Manual Powering Up the Varian 705 DS Dissolution Apparatus Turn on the dissolution apparatus A Power up Self Test POST routine executes The pass fail result for each test displays in order to verify correct functioning of the instrument The system serial number and the firmware version display at the bottom of the main screen After successful completion of the POST the following screen displays Ser 9 1254 5679 W1 0 After three seconds the main screen displays ca 250 RP
25. ents can cause death serious injury or painful electric shock Panels or covers that are retained by fasteners which require the use of a tool for removal may be opened only by Varian trained Varian qualified or Varian authorized service engineers Consult the manuals or product labels supplied with the dissolution apparatus to determine which parts are operator accessible Application of the wrong supply voltage connection of the instrument to an incorrectly wired supply outlet or lack of proper electrical grounding can create a fire hazard or a potentially serious shock hazard and could seriously damage the instrument and any attached ancillary equipment Always use a three wire outlet with ground connection which is adequately rated for the load The installation must comply with local state and federal safety regulations Do not connect the instrument to the main power supply until you have made sure that the operating voltage is correctly set for the main power supply in the specific outlet in your laboratory to which the equipment will be connected Other Other specific warnings and cautions appear in the manuals where appropriate and detail the specific hazard describe how to avoid it and specify the possible consequences of not heeding the warning or caution Warning A Warning message appears in the manual when failure to observe instructions or precautions could result in death or injury Symbols depicting the natu
26. eshooting Printer Self Test You can test the print head and ribbon only after inserting paper Do not attempt to print without paper Follow these steps to perform a printer self test Step 1 Turn off the dissolution apparatus Step 2 Press and hold the printer toggle switch in the Paper feed position Step 3 Turn on the dissolution apparatus Step 4 Hold the printer toggle switch until printing begins The printer prints a list of the current configuration settings and performs a continuous print test Step 5 Press the printer toggle switch to the OnLine Off Line position to stop the printing operation Step 6 The printer is ready to resume normal operation Printer Configuration Note The printer configuration is set by the factory This procedure Ie should be performed only if the printer displays erroneous characters Contact the Dissolution Systems Service Department for assistance if necessary Step 1 Turn off the dissolution apparatus Step 2 Press and hold the printer toggle switch in the OnLine Off Line position while turning on the instrument Step 3 Hold the printer toggle switch in the OnLine Off Line position for six seconds after the instrument is turned on then release the switch Step 4 The printer should print SETUP MENU and CONFIGURE NEXT OK If this message does not print repeat steps 1 through 3 Varian Inc Page 48 Varian 705 DS Dissolution Revision
27. h care Our QC laboratory has checked the shafts for straightness to ensure that they will operate without significant wobble If you must clean or handle them while they are still mounted on the instrument use minimal pressure on the shaft to prevent them from bending While in the chucks just a little bit of pressure exerted on the shaft especially near the blade or basket can easily bend the shaft and cause significant wobble 5 Use care when removing vessels from the apparatus while the paddles or basket shafts are installed so that you do not bump them 6 When attaching or removing baskets do not bend the clips excessively 7 Please store paddles and basket shafts properly between uses Do not simply place these items in a drawer They will be subject to nicks chips and scratches as they Varian Inc Page 40 Varian 705 DS Dissolution Revision B 01 06 Maintenance and Troubleshooting Apparatus Operator s Manual P N 70 9041 bump against each other Place them back into the original styrofoam shipping container or other appropriate container between uses This will prevent them from coming into contact with each other or anything else in the storage area Basket Care 1 When using with corrosive materials such as hydrochloric acid or media containing salts be sure to rinse them thoroughly with deionized water immediately after each use and dry thoroughly with a soft towel or cloth Please do not clean baskets
28. ies and heater circulator Step 1 Open the carton and check the contents for damage which may have occurred during shipping Shipping damage rarely occurs but if it does contact both the carrier who delivered the instruments and the Dissolution Systems Service Department Though claims for damage should be filed with the carrier we can help you file a claim Step 2 Carefully remove the apparatus water bath accessory kit and heater circulator from their shipping carton Warning Because of its heavy weight two people should lift the apparatus Do not lift the apparatus by the drive unit Lift by holding the legs or vessel plate Varian Inc Page 18 Varian 705 DS Dissolution Revision B 01 06 Setting Up Apparatus Operator s Manual P N 70 9041 Step 3 Remove cushioning material and tape If any item is missing contact the Dissolution Systems Service Department or your local representative for replacements Step 4 Place the apparatus and heater circulator on a clean dry and level section of the bench A Warning The electrical connection at the back of the apparatus is the primary disconnect for the instrument The apparatus should be positioned to allow accessibility to the power cords for easy disconnection Leveling Step 1 Step 2 Step 3 Your Dissolution Apparatus Place the level provided in the accessory kit on the vessel table Check the level of the instrument in
29. l not to bend or distort the basket Step 10 Repeat steps 2 9 for each of the remaining positions Step 11 Lower the drive unit until it stops The baskets are set to their USP specified height of 25 2 mm above the bottom of the vessel Removing Paddles or Baskets Shafts To remove the paddles or basket shafts complete the following steps Step 1 Step 2 Loosen the 1 8 inch Allen screw on the shaft collar and remove the collar Repeat this procedure with all positions Raise the drive unit to the upmost position and gently remove the basket shafts taking care not to drop them into the vessels Varian Inc Revision B 01 06 Varian 705 DS Dissolution Page 25 P N 70 9041 Apparatus Operator s Manual Setting Up Centering Verification To verify the centering of the EaseAlign vessels complete the following steps Step 1 Locate the blue EaseAlign Centering Verification Gauge FIGURE 3 EaseAlign Centering Verification Gauge Step 2 Lower the drive unit until the top of the paddle blade or basket is approximately 2 inches 5 cm below the rim of the vessel Step 3 Place the gauge against the shaft with the shaft resting in the radial cutout Step 4 Slide the gauge down the shaft until the tapered ends pass through the slots in the EaseAlign centering ring See Figure 2 EaseAlign centering ring on page 22 The tapered sides of the gauge rest against the inside rim of the vessel The gauge is lev
30. m and possibly damage the printer mechanism Step 10 Release the printer toggle switch Step 11 Turn the paper roll to take up any slack in the paper feeding to the printer Step 12 Place the paper roll into the paper compartment Step 13 Replace the paper roll cover If the cover is difficult to remove or replace the left and right edges can be trimmed or shaved with a utility knife allowing the cover to slide easier Step 14 Toggle the printer online by pressing the printer toggle switch to the OnLine Off Line position The Ready LED illuminates Toggling Your Printer Online Complete these steps to toggle your printer online Step 1 Step 2 Toggle the printer online by pressing the printer toggle switch to the OnLine Off Line position When the printer is off line the Ready LED does not illuminate Release the switch and it returns to the center position The Ready LED illuminates and a READY message prints if the PRINT READY command has not been turned off See Printer Configuration on page 47 for instructions on turning on and off the PRINT READY command When you first turn on the instrument it prints a READY message to assure you that the built in microprocessor is operating properly When you turn off the printer wait at least three seconds before turning it on again Varian Inc Revision B 01 06 Varian 705 DS Dissolution Page 47 P N 70 9041 Apparatus Operator s Manual Maintenance and Troubl
31. menu screen options Options Function Esc Press Esc to return to the system menu screen Serial The serial number is factory set This option is available for use as applicable in servicing the apparatus Clock Use this option to set the system date and time See Setting the Clock on page 29 Screen Use this option to change the screen contrast the screen brightness and the touchscreen calibration See Setting the Screen Contrast and Brightness on page 28 Com Port Use this option to enter the communication port identification number for the dissolution apparatus See Setting the Communication Port Identification Number on page 30 Varian Inc chapters Maintenance and Troubleshooting Periodic Maintenance Warning The dissolution apparatus contains electrical circuits devices and components operating at dangerous voltages Contact with these circuits devices and components can cause death serious injury or painful electric shock Periodic maintenance needs may vary depending on frequency of instrument usage Daily Maintenance See Paddle Basket Shaft Care on page 39 Basket Care on page 40 and Water Bath Care on page 41 as applicable for additional information on proper maintenance of your equipment e All parts exposed to the dissolution media should be cleaned after each use Parts made from stainless steel such as paddle
32. n displays BATH the vessel temperature displays on the screen When the button displays VESSEL the water bath temperature displays on the screen Press the temperature display on the main screen to set the water bath temperature or print the vessel temperatures as applicable To set the water bath temperature press the water bath temperature display Press the desired button 32 37 or 37 4 to set the water bath temperature to the indicated value Or use the up and down arrows to change the water bath temperature by 0 1 C at atime Press OK to save the temperature Press Cancel to discard the value To print the vessel temperatures place the temperature probe in vessel 1 allow the temperature to stabilize and press the vessel field The current temperature for vessel 1 prints Move the temperature probe to vessel 2 allow the temperature to stabilize and press the vessel field again The current temperature for vessel 2 prints Continue moving the temperature probe allowing the temperature to stabilize and pressing the vessel field until the current temperatures for all the vessels print Note the vessel temperature is read individually with the optional vessel probe This information is can be recorded using the optional printer The reading is used to determine whether all the vessels are at the correct temperature prior to the start of a test RPM Press the speed display on the main screen to set the RPM Press the desi
33. on Do not use cleaning compounds containing ammonia or abrasive cleaners on your water bath The water bath supplied with the Varian 705 DS Dissolution Apparatus should be maintenance free except for an occasional cleaning If you use a water bath algaecide or clear bath product ensure it is compatible with PETG and acrylic The flow paths in the heater circulator are primarily stainless steel and should tolerate most clear bath formulations Check with the product manufacturer to be sure the product is safe for your water bath 1 All of our water baths are fabricated entirely of commercial grade acrylic When using them with corrosive materials such as hydrochloric acid or media containing salts be sure to rinse them thoroughly with deionized water immediately after each use and dry thoroughly with a soft towel or cloth 2 Do not clean with abrasive cleansers or cloths Use deionized water whenever possible If you must use a cleanser or solvent be sure that it is as mild as possible non abrasive and fully compatible with PETG and acrylic before use If in doubt call the service department for advice before proceeding 3 Do not use ammonia window cleaning sprays kitchen scouring compounds or solvents such as acetone gasoline benzene alcohol carbon tetrachloride or lacquer thinner These can scratch the material s surface and or weaken it causing small surface cracks called crazing 4 Our recommendations includ
34. or shafts with abrasive cleansers or cloths especially if they re gold or Teflon coated Mesh openings on baskets could enlarge which could have an effect on results Use deionized water whenever possible If you must use a cleanser or solvent be sure that it is as mild as possible non abrasive and fully compatible with fluorocarbons and stainless steel before use If in doubt contact the service department for advice before proceeding We recommend that you do not use a laboratory dishwasher Clean baskets only by hand The high temperatures to which your baskets would be subject in a dishwasher may damage the fluorocarbon coating Use caution when handling baskets It is important that they retain their cylindrical shape so take care not to kink or bend the mesh Check frequently to ensure that the mesh is completely open and that there are no rips or tears Please store baskets properly between uses Do not simply place these baskets in a drawer They will be subject to nicks chips and scratches as they bump against each other and they may get bent out of shape Place them back into the original shipping container or other appropriate container between uses This will prevent them from coming into contact with each other or anything else in the storage area Varian Inc Revision B 01 06 Varian 705 DS Dissolution Page 41 P N 70 9041 Apparatus Operator s Manual Maintenance and Troubleshooting Water Bath Care Cauti
35. re of the specific hazard are also placed alongside warnings Varian Inc Revision B 01 06 Varian 705 DS Dissolution Page 9 P N 70 9041 Apparatus Operator s Manual Safety Practices and Hazards These symbols are also used on warning labels attached to the instrument When you see one of these symbols you must refer to the relevant operation or service manual for the correct procedure referred to by that warning label The meaning of the symbols that appear alongside warnings in this manual are as follows Electrical shock Caution Refer to accompanying documents Read all warnings and cautions carefully and observe them at all times Caution A Caution message appears in the manual when failure to observe instructions could result in damage to equipment Varian supplied and or other associated equipment A Note appears in the manual to give advice or information Varian Inc Page 10 Varian 705 DS Dissolution Revision B 01 06 Safety Practices and Hazards Apparatus Operator s Manual P N 70 9041 Information Symbols Switches main power on Switches main power off Indicates single phase alternating current Indicates the product complies with the requirements of one or more European Union EU directives _ Indicates specific equipment meets consensus based standards B of safety to provide assurance required by OSHA that these A J products are safe for use in the workplac
36. red button 50 75 100 or 250 to set the speed to the indicated value Or use the up and down arrows to change the speed by 1 RPM at a time Press OK to save the RPM Press Cancel to discard the value Run Stop The Run Stop button toggles between the options Press Run to begin a test If the test duration has been programmed the test automatically stops when the elapsed time equals the test duration Alternately press Stop to stop the test TEST PAUSED PRESS STOP TO END THE TEST PRESS RESUME TO CONTINUE THE TEST displays Press Resume to continue the test the test continues Press Stop The main screen displays Varian Inc Revision B 01 06 P N 70 9041 Varian 705 DS Dissolution Page 35 Apparatus Operator s Manual Operating and Programming Options Function Elapsed test time System date and time The elapsed time and system date and time display at the bottom of the main screen When an internal error occurs the error information displays in this area Press the display bar to acknowledge the error and silence the alarm System Menu Bath 7 Following is a description of the system menu screen options Options Function Esc Press Esc to return to the main screen Bath Temp Press Bath Temp to set the water bath temperature Use the plus and minus buttons to increment or decrement the entry Press OK to save the water bath temperature Press Cancel to discar
37. s 8 Other 8 General 10 WEEE Directive 11 Chapter 2 Introduction 13 Conventions Used in this Manual 15 USP Suitability Test 16 USP Physical Parameters 16 Varian Inc Table of Contents Chapter 3 Chapter 4 Chapter 5 Setting Up 17 Unpacking Your Equipment 17 Leveling Your Dissolution Apparatus 18 Electrical Connections 19 Connecting the Heater Circulator 19 Installing and Centering the Vessels 21 Installing Receptor Shafts 22 Setting Paddle Height 23 Setting Basket Height 23 Removing Paddles or Baskets Shafts 24 Centering Verification 25 Printer Setup 26 Powering Up the Varian 705 DS Dissolution Apparatus 27 Preliminary Functions 27 Setting the Screen Contrast and Brightness 28 Setting the Clock 29 Setting the Communication Port Identification Number 30 Filling the Water Bath 31 Operating and Programming 33 System Status 33 System Menu 35 System Menu 2 36 Maintenance and Troubleshooting 37 Periodic Maintenance 37 Daily Maintenance 37 Paddle Basket Shaft Care 39 Basket Care 40 Water Bath Care 41 Visual Checks 43 Varian Inc Table of Contents Chapter 6 Report Center Impact Printer 44 Installing the Cartridge Ribbon 44 Replacing the Paper Roll 45 Toggling Your Printer Online 46 Printer Self Test 47 Printer Configuration 47 Water Bath Temperature Probe Accuracy Test 49 Fuse Replacement 51 Troubleshooting 52 Service and Warranty 55 Exclusions and Limitations 56 Obtaining
38. s all USP EP JP and FIP guidelines and is shipped with a calibration certificate for the physical parameters specific to each instrument The Varian 705 DS Dissolution Apparatus has a chemical resistant design that includes type 316 stainless steel support legs and acid resistant base plate Warning The dissolution apparatus contains electrical circuits devices and components operating at dangerous voltages Contact with these circuits devices and components can cause death serious injury or painful electric shock Varian Inc Revision B 01 06 Varian 705 DS Dissolution Page 15 P N 70 9041 Apparatus Operator s Manual Introduction FIGURE 1 Varian 705 DS Dissolution Apparatus Caution Panels or covers that are retained by fasteners which require the use of a tool for removal may be opened only by Varian trained Varian qualified or Varian authorized service engineers Conventions Used in this Manual e Screen options you are asked to press are in bold For example press Esc e Sequences you are asked to press appear like this Menu gt RPM Note Remember to return the warranty card supplied with this manual Completing and returning the card ensures your right to protection under the terms and conditions of your warranty It also enables us to better assist you in the event of any problems Additionally it guarantees you will be informed of any issues that arise concerning
39. s ample room for easy manual sampling Automated analysis can be accomplished via resident sampling cannulas mounted in the evaporation covers The alignment features on the Varian 705 DS Dissolution Apparatus include locking collars which are easy to slide on and secure into place These collars hold the shaft securely while in operation yet allow the shaft to be raised and lowered to precisely the correct height for easy staggered starts using either paddles or baskets Additionally the precision engineered self aligning EaseAlign centering rings eliminate time consuming manual adjustments by automatically centering vessels based on the interior wall The included independent heater circulator is designed for use with the Varian 705 DS Dissolution Apparatus Isolated from the apparatus the chance of vibrational influences from the heater circulator are eliminated Due to its compact size the heater circulator can be housed beneath the base plate conserving valuable bench space A PETG polymer water bath allows for uniform temperature control of all vessels The water bath is clear and seamless offering an unobstructed view of the vessels The water bath is a single piece unit with a built in drain hose for easy cleaning An optional stand alone dot matrix printer can be used for documentation purposes providing hard copies of your test parameters including elapsed time RPM and temperature The Varian 705 DS Dissolution Apparatus meet
40. s mark signifies that this product has been tested to U S standards and certified for the U S market The cTUV mark signifies that this product has been tested to Canadian standards and certified for the Canadian market When the two marks are coupled the cTUVus mark signifies that this product has been tested to standards and certified for both markets WEEE Directive All Varian products that are subject to the WEEE directive shipped after August 13 2005 are compliant with the WEEE marking requirements Such products are marked with the crossed out wheelie bin WEEE symbol shown on page 10 in accordance with European Standard EN 50419 This symbol on the product or on its packaging indicates that this product must not be disposed of as unsorted municipal waste The separate collection and recycling of your waste equipment at the time of disposal will help to conserve natural resources and ensure that it is recycled in a manner that protects human health and the environment For more information on collection reuse and recycling systems please contact your local regional waste administration your local distributor or Varian Inc Varian Inc Page 12 Varian 705 DS Dissolution Revision B 01 06 Safety Practices and Hazards Apparatus Operator s Manual P N 70 9041 This page was intentionally left blank except for this message Varian Inc chapter2 Introduction The Varian 705 DS Dissolution Apparatus is de
41. signed for dissolution testing of a variety of pharmaceutical compounds including tablets capsules transdermal patches and membranes It can be configured as USP Apparatus 1 2 5 or 6 The unit has eight vessel locations and ships standard as a six spindle apparatus As an eight spindle apparatus it can accommodate six samples a standard and a blank Optionally the seventh and eighth vessel positions can be used for at temperature media replacement The Varian 705 DS Dissolution Apparatus delivers many features designed to simplify operation including microprocessor control easy to read displays and innovations to guarantee system alignment The units microprocessor control allows touchscreen entry of operating parameters including temperature RPM and elapsed time The LCD provides real time monitoring of RPM water bath or vessel temperature measurement and the elapsed time since test initiation The manual lift mechanism is easy to use due to the smooth functioning of the dissolution apparatus The instrument glides into place and a single turn locks or unlocks the drive unit A pressurized piston equilibrates the weight of the drive unit for easy positioning Varian Inc Page 14 Varian 705 DS Dissolution Revision B 01 06 Introduction Apparatus Operator s Manual P N 70 9041 The working height with the drive unit lowered is approximately 9 inches 23 cm between the vessel plate and the drive unit which allow
42. tability and fitness for a particular use In no event will Varian Inc be liable for any indirect incidental or consequential damages arising from the use of this product This warranty gives you specific legal rights which may vary from state to state or province to province so you may have other rights and some of these exclusions may not apply to you Varian Inc Page 57 Revision B 01 06 Varian 705 DS Dissolution Service and Warranty P N 70 9041 Apparatus Operator s Manual Exclusive Remedies The remedies provided herein are the customer s sole and exclusive remedies In no event shall Varian Inc or its representatives be liable for any direct indirect special incidental or consequential damages whether based on contract tort or any other legal theory Some states or provinces do not allow the exclusion or limitation of incidental or consequential damages so the above limitation or exclusion may not apply to you Varian Inc Page 58 Varian 705 DS Dissolution Revision B 01 06 Service and Warranty Apparatus Operator s Manual P N 70 9041 This page was intentionally left blank except for this message Varian Inc Index b basket care 40 basket height setting 23 basket shaft care 39 c cartridge ribbon 44 clock setting 29 conventions 15 e electrical connections 19 exclusions 56 exclusive remedies 57 f fuse replacement 51 h hazards 7 i installing an
43. te The EaseAlign centering rings have two large holes to accommodate the plastic pegs adjacent to each vessel location on the vessel plate Press one EaseAlign centering ring firmly into each vessel with the alignment fingers inside the vessel See Figure 2 EaseAlign centering ring on page 22 Varian Inc Page 22 Varian 705 DS Dissolution Revision B 01 06 Setting Up Apparatus Operator s Manual P N 70 9041 Step 3 When pushed down securely the vessels are automatically aligned and require no further adjustment FIGURE 2 EaseAlign centering ring holes for plastic pegs Installing Receptor Shafts To install the receptor shafts complete the following steps Step 1 Raise the drive unit to its maximum height Step 2 Insert a shaft into each spindle until at least half of the shaft is above the top of the spindle Step 3 Place a shaft locking ring on the top of each shaft and slide it down until it rests on the shaft collar Step 4 Tighten the set screws using the 7 64 inch T handle Allen wrench provided Leave the drive unit in the fully raised position Varian Inc Revision B 01 06 Varian 705 DS Dissolution Page 23 P N 70 9041 Apparatus Operator s Manual Setting Up Setting Paddle Height Step 1 Attach a paddle shaft to each receptor shaft Step 2 Place a 25 mm height sphere in each of the vessels Step 3 Lower the drive unit until it stops Step 4 Loosen each set screw and caref
44. the following additional information The most useful thing about this book is This manual would be more helpful if My general impressions of this book are May we contact you regarding your comments YES NO If yes please write your name address and telephone number here Please return this form via mail to Technical Writing Dissolution Systems Varian Inc 13000 Weston Parkway Cary North Carolina 27513 2250 USA Optionally you can return this form via fax at 1 919 677 1138 Always feel free to telephone us to discuss your comments at 1 800 229 1108 Varian 705 DS Dissolution Apparatus Operator s Manual P N 70 9041 Revision B
45. the return inlet located on the left side of the heater circulator Secure the tubing clamp Do not over tighten as damage may occur Recheck all connections Note U gt You can cut the tubing to any length required if the precut pieces are too long Step 9 Connect the six pin cable to the rear of the heater circulator and the other end into the position marked BATH HEATER on the dissolution apparatus rear panel Varian Inc Revision B 01 06 Varian 705 DS Dissolution Page 21 P N 70 9041 Apparatus Operator s Manual Setting Up Step 10 Locate the water bath temperature probe Install the temperature probe into the vessel plate using the grommet provided Plug the probe s cable in the position marked BATH TEMP on the dissolution apparatus rear panel Step 11 Plug the vessel temperature probe cable into the position marked VESSEL PROBES Step 12 Fill the water bath with water to approximately 3 4 full and check for leaks Recheck the level of the instrument Installing and Centering the Vessels The apparatus is supplied with self centering EaseAlign centering rings EaseAlign centering rings keep the vessel centered at all times without the use of tools and prevent vessels from floating even when they are empty Step 1 Step 2 The EaseAlign centering rings are normally shipped in place on the vessel plate Remove the rings from the vessel plate Place each of the vessels on the vessel pla
46. ully lower each paddle assembly until the bottom of the paddle blade rests against the height sphere Step 5 Tighten each set screw securely Step 6 Rotate each shaft locking ring so the drive positioning teeth on both the shaft locking ring and the shaft collar rest against one another locking the shaft in place Step 7 Raise the drive unit to its home position Step 8 Remove the height spheres from the vessels Step 9 Lower the drive unit until it stops The paddles are set to their USP specified height of 25 2 mm above the bottom of the vessel Setting Basket Height Step 1 Attach a basket shaft to each receptor shaft Step 2 Clip the basket height gauge onto the first shaft Step 3 Lower the drive unit until it stops Varian Inc Page 24 Varian 705 DS Dissolution Revision B 01 06 Setting Up Apparatus Operator s Manual P N 70 9041 Step 4 Loosen the set screw and carefully lower the basket shaft assembly until the bottom of the gauge rests against the bottom of the vessel Be careful not to use excessive pressure or the bottom of the vessel may crack Step 5 Tighten the set screw securely Step 6 Rotate the shaft locking ring so the drive positioning teeth on both the shaft locking ring and the shaft collar rest against one another locking the shaft in place Step 7 Raise the drive unit to its home position Step 8 Remove the height gauge from the basket shaft Step 9 Attach a basket being carefu
47. water bath and clean the bath thoroughly Refill the water bath and add an algaecide e Clean and lubricate the upper and lower portion of the support legs with the recommended synthetic lubricant Varian Inc Revision B 01 06 Varian 705 DS Dissolution Page 39 P N 70 9041 Apparatus Operator s Manual Maintenance and Troubleshooting e It is recommended that the water bath temperature probe jack is checked for surface corrosion and wiped clean with a soft cloth or nonabrasive pad every one to three months Note Depending on the frequency of use it may be necessary to complete this maintenance procedure more often Paddle Basket Shaft Care 1 When using with corrosive materials such as hydrochloric acid or media containing salts be sure to rinse them thoroughly with deionized water immediately after each use and dry thoroughly with a soft towel or cloth 2 Do not clean with abrasive cleansers or cloths Use deionized water whenever possible If you must use a cleanser or solvent be sure that it is as mild as possible non abrasive and fully compatible with fluorocarbons and stainless steel before use If in doubt call the service department for advice before proceeding 3 We recommend that you do not use a laboratory dishwasher Clean paddles and basket shafts only by hand The high temperatures to which your items would be subject in a dishwasher may damage the fluorocarbon coating 4 Be sure to handle wit
48. your equipment such as upgrades retrofits or regulatory changes Varian Inc Page 16 Varian 705 DS Dissolution Revision B 01 06 Introduction Apparatus Operator s Manual P N 70 9041 USP Suitability Test Before initial use of any dissolution instrument and periodically thereafter the USP requires that you run an Apparatus Suitability Test with both disintegrating and non disintegrating USP Dissolution Calibrators These calibrator tablets are available from the USP at the following address USP NF Reference Standards 12601 Twinbrook Parkway Rockville MD 20852 301 881 0666 Complete instructions come with the calibrator tablets Calibration tests can be very sensitive to factors such as paddle or vessel misalignment vessel shape vibration of the system age of the calibrator tablets and reference standards and many other factors USP Physical Parameters In addition to the Apparatus Suitability Test several physical parameters must be monitored such as shaft wobble centering speed and shaft verticality A Certificate of Compliance is included with all dissolution apparatus Contact the Dissolution Systems Service Department for more information on USP Physical Parameters Varian Inc Chapter 3 Setting Up Unpacking Your Equipment The Varian 705 DS Dissolution Apparatus is shipped in one box The box contains the dissolution apparatus including the glassware PETG water bath accessor
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