Isocomp Service Manual.DOC
Contents
1. mreno Um co No approve pare ve any iud A m sow mi t Mas i i aw k 3 E 750Wv ripple 1 MA IA sox T 4 z n 88 470 arov E Tm z 150 merov TL sty i A Ls wants m 10 2307 J i s sb 258 nee 23 J As lt 1 450Wv rippi 25 MA DC 1 15 ji ions ripple 3 x n 225 gt Iw our my m sxer n ni E ow haass 4 3 Ey rer av ay aur 28 ae m 8 a a sm abou nm 1 tw ripple wg 220 MA DC b b m 85 adn LP ape LP UEM Mav er 5 1 ees osjo L ose z sav these uss u26 A 26 8 afe tat STATO 3 1s T m 2 b b S uw der SPE gt 4 m i ACE ur 4 B ESE mesos 3 H 3 vss k e picos s H m 83 5 4 n 1 oa le Ray our x Blur Bk paeau m me VA s ZAROTA ES n 5 ar oOo z soa r x vl we ju SEER wann h 11 ones gt je pace S H oz Ds UPPL PRINTER POWER SUPPLY gt gt 12. 22 Note on schematics In the Adobe Acrobat format of this manual the schematics are scalable If the schematics are printed on 8 by 11 paper they are unreadable To print the schematics so that they are readable select the print function in the Adobe Acrobat reader and print only the schematic pages to a printer capable of printing on 11 by 17 paper If a printer capable of printing on 11 by 17 paper is not available then by zooming in the Adobe Acrobat reader the schematics can be viewed quite nicely ISOCOMP I SERVICE MANUAL INTRODUCTION The ISOCOMP I Gamma Counter and Data Reduction System is the latest in a long line of compact yet powerful bench top laboratory instruments form MGM Instruments A 1 5 inch square Sodium Iodide Crystal turns the gamma radiation emitted from a sample containing or CO into an electrical pulse that is amplified and counted by the computer in the Main PCB Menu driven instructions prompt the user to insert the correct tube and press the proper keys from calibration to programming to operation Protocols may be programmed and stored in permanent non volatile memory Data reduction routines are selected by the user during programming see Operator s Manual for programming instructions and further information on the data reduction routines Types of test that can be performed include RIAs IRMAs Uptakes screening etc Simultaneous I and CO counting is also possible for applicat
3. ISOCOMP DRAWING NUMBER 998001A ueoadosr I uos OT LZ 0 SC U2 DATA PINS 00000 00001 00010 00100 00110 01000 01001 01010 01100 01110 0000 0001 0010 0100 0110 1000 1001 1010 1100 1110 DO D1 D2 D3 D4 18 17 16 ABCDE RESUME 4 PROGRAM N lt KO CO MAJO PR e zBexas a OOOOOJOOOM REVISION RECORD U2 PIN 6 MM74C923 LEAR KBD IRQ RESUME ra a COUNT a PROGRAM m a A D MGM INSTRUMENTS INC REVISION ISOCOMP KEYBOARD APPLICATION DRAWING NUMBER PART NUMBER TITLE T 42S dNODOSI 80 ZI TIA 80 00 Sc
4. m i i sa gt 2 z sem a t 2 gt Au ul MCHBBB vo e Le pAs GE E E 5 HB Ut MC1489 n K a E i s s PE PE rm REP Lag dec M aoe 008 mm Her cn FEE 2 aj pe EL s ER rei ip Wn 51 55 3T ES m Hs B mur 415 m 45 ORG i n3 rp M po HI 5 s 50 she mE m i i 7 js YS n Don t use OKI chips for 82c55 NOTE NSTALL JP3 FOR NORITAKI DISPLAY ONLY EN Ss lt 2 a 2 a e a ile lt lt m lt gt lt lt x i C57 COUNTS nas COUNTS INSTRUMENTS INC APPROVED DRAWN BY ZM REVS E T NAME TITLE MAIN BOARD APPLICATION DRAWING NUMBER ISQCOMP 0700 0003 00 LO TL nui Z uOS GOTOST 663 00 LI YOS
5. KEYBOARD REPLACEMENT Turn power off and remove the power cord from the wall outlet Remove the Top Cover Remove Front Panel Remove six screws securing the Keypad to the Front Panel Remove keypad Install replacement keypad Replace six screws to secure the new Keypad Replace Front Panel Replace Top Cover RR DISPLAY REPLACEMENT Turn power off to the instrument and remove the power cord from the wall receptacle Remove the Top Cover and Front Panel as described on page 2 3 Disconnect the two wires from the Display Remove the four screws securing the Display Remove the Display If there is a blue filter on the original display it may be necessary to transfer it to the new display A piece of tape can be used to hold the filter in place while the display is being secured Install the new display If the original Display was manufactured by Futaba recognizable by a 40 conductor ribbon cable connection to the main board J 3 on the main board should be open If the Display was manufactured by Noritake discreet wire harness connection to the main PCB J 3 on the main pcb must be shorted Page 17 of 24 ISOCOMP I SERVICE MANUAL PRINTER REPLACEMENT Turn the Instrument off and remove the power cord from the wall receptacle Remove the Top Cover as described above Remove the Printer Harness from the printer by gently pulling the connector away from the printer Remove the
6. 2 R pacs PH 5V DC E 35 XFORMER rig RIG pa pi 1 m C w iu A Cas a Qhan Sy E ver om J 4 ces 8 1 x P us i XI e Eee diee 4 ma E Bum 258 9 T 2 MGM INSTRUMENTS INC i caa vaso l DATE 9 6 96 APPROVED DRAWN BY ZM BSE SE s 2 SCALE REVISION E 453 oooer PART NAME TITLE Fe id T MAIN BOARD APPLICATION DRAWING NUMBER OCONEE 0700 0003 00 OT LZ Zo 8 0tuf 600v 01uf 600v O1ut 600v 0l aga 03 R13 820K 741V Oluf 1 4kv P2 12 REVISION RECORD LTR ECN NO DATE J2 1 1 Z 47 iD gt sroa R CONCX J2 3 gt d m d 88 E r E E 01 74v D 6 1V 3 s 8 A gt 2 z 8 i t B lt D i l 05 Q 2 0 5 s MGM INSTRUM EN TS INC DATE SIZE JUNE 1995 APPROVED B DRAWN BY ZM REVISION PART NUMBER TITLE APPLICATION PR EAMPLIF ER
7. ENTER ACCEPTS DISPLAYED DATA START BEGINS A NEW PROTOCOL PROG EDITS PROTOCOL PARAMETERS LIST PRINTS A LIST OF PROTOCOL PARAMETERS CAL INITIATES A CALIBRATION ROUTINE Page 4 of 24 ISOCOMP I SERVICE MANUAL CALIBRATION The Isocomp I gamma counter has the ability to self calibrate utilizing a calibration source of either or the long life mock I D which is recommended To Calibrate the instrument Press the CAL button on the front panel keypad The following is displayed The instrument serial number will be displayed If the serial number is correct press ENTER If it is not correct enter the proper serial number and press ENTER The following is displayed Press 1 to initiate a calibrate sequence The following is displayed The instrument prompts the user to insert a source Insert the calibration source and press ENTER The instrument will take approximately 1 minute to complete its calibration At the conclusion of a successful calibration a calibration number will be printed and the following will be displayed Press 1 to perform a background check The Isocomp will take 10 1 minute counts and store the average of the backgrounds for I and CO in memory for use if desired during an assay utilizing the background subtract parameter Page 5 of 24 ISOCOMP I SERVICE MANUAL Consult operator s manual for more information After the background count is complete the following will be displayed Press 0 to skip
8. I SERVICE MANUAL It is now possible to lift the Front Panel off of the base and gain access to the Main PCB and other components inside the instrument It is necessary to disconnect the cables from the keypad and display in order to completely remove the panel COMPONENT REPLACEMENT Replacement of internal components involves opening the instrument and exposing a possible shock hazard Please exercise extreme caution when working on the inside of the instrument Voltages inside can exceed 600VDC CAUTION INTERNAL VOLTAGES CAN EXCEED 600VDC REMOVE POWER BEFORE REMOVING COVERS SERVICE BY QUALIFIED PERSONNEL ONLY FUSE REPLACEMENT To replace the fuse s on the ISOCOMP it is first necessary to remove the power cord from the power entry module located at the left rear of the instrument Turn the power to the instrument off with the power switch located near the power cord 2 Remove the power cord from the wall receptacle 3 Remove the power cord from the power entry module 4 Using a small flat blade screwdriver or something equivalent remove the fuse block from the power entry module Page 16 of 24 ISOCOMP I SERVICE MANUAL 5 Remove the bad fuse s and replace with a 1 4 amp Slo Blo fuse 6 Install the fuse block into the power entry module NOTE Observe the voltage setting on the outside of the fuse block The proper voltage setting should be facing the bottom side of the Power Entry Module as shown
9. ISOCOMP 1 GAMMA COUNTER AND DATA REDUCTION SYSTEM SERVICE MANUAL MGM INSTRUMENTS 925 SHERMAN AVENUE HAMDEN CT 06514 U S A 203 248 4008 800 551 1415 http www mgminstruments com e mail stevemgm Q pcnet com INTRODUC HON 3 PPE CUA ALLO INS de dace 3 MOM BENE nn 4 ALI SMELL 5 SAMPLEE PRINTOUT eee ee eroe RR A eR pr Re 9 TEST PROTOCOL PRINTOUT sette n RES RD RR eH 13 TROUBLESHOOTING eto e PA A eb wine 14 CIELO gps 15 COVER REMOVAL s ette I UN NA MM ME Me aM DN UNE 15 COMPONENT REPIEACEBNIBNT AREAS 16 FUSE REPLACEMEN T i de AE A A haa shes RM UE 16 KEYBOARD REPLACEMENT sisisi e d Hd ui i Ed nb 17 DISPLAY REPLACEMENT wie iicet eset ei t EH RE HR REUNIR SENE EUER GERENS SERT S 17 PRINTER REPLACEMENT ete e t e PER GENA AA RR 18 MAIN PCB 18 REMOVAL REPLACEMENT OF PRINTER POWER SUPPLY 19 DETECTOR 20 SCHEMATICS
10. d Press ENTER The following is displayed Press 2 5 ENTER The following is displayed Press 5 ENTER The following is displayed Press 10 ENTER The following is displayed Page 11 of 24 ISOCOMP I SERVICE MANUAL Press 15 ENTER The following is displayed Press 30 ENTER The Main Menu is displayed Press the START key and select PROTOCOL 1 ENTER The following is displayed Select 2 Enter and enter the following values as prompted PROMPT TOTAL REP 1 NSB REP 1 BO STD 1 REP 1 STD 2 REP 1 STD 3 REP 1 STD 4 REP 1 STD 5 ENTER 80619 6464 58009 50660 43799 34669 28032 18873 The printout for this protocol can be found on the following page Page 12 of 24 ISOCOMP I SERVICE MANUAL TEST PROTOCOL PRINTOUT 58009 58009 STANDARD 1 4 50660 AVG 50660 STANDARD 2 5 43199 AVG 43799 STANDARD 3 6 34669 AVG 34669 STANDARD 4 7 28032 AVG 28032 STANDARD 5 8 18873 AVG v9 8 1 6 15 4 ig 2 1 Page 13 of 24 ISOCOMP I SERVICE MANUAL TROUBLESHOOTING The following chart is intended to assist technical personnel in the troubleshooting and repair of the ISOCOMP I Gamma Counter and Data Reduction System CAUTION Hazardous voltages exist inside the instrument Turn the power off and remove the power cord from the wall outlet prior to servicing Covers are to be removed by qualified per
11. ector Make sure that the Preamp is pushed all the way onto the pins of the detector Install the screws from the bottom of the instrument to anchor the PREAMP bracket Tighten the clips Replace the Preamp Screen Connect the High Voltage Cable and the Preamp Power Signal Cables Replace the Top Cover assembly Check the operation of the replacement Preamp by running a calibration routine DETECTOR REPLACEMENT Turn the ISOCOMP off and remove the power cord from the wall socket Remove the Top cover assembly as described on page 2 3 Remove the Preamp shield Remove Preamp Mounting Bracket Remove well liner Page 20 of 24 ISOCOMP I SERVICE MANUAL Gently pull the detector out of the Lead Block The Lead tube will come out along with the Detector Place the Lead Tube on the replacement detector NOTE The original detector will have a black foam packing on the outside of the large diameter end Make sure that the replacement has some sort of packing on it to reduce the chance of the Detector being damaged during transport Insert the head of the detector into the lead block Insert the well liner into the top of the lead block This will serve to line up the detector with the PREAMP Install the PREAMP onto the pins of the detector Install the screws into the PREAMP mounting bracket from the underside of the Isocomp base Check all connections from the PREAMP to the Main Board Place all the covers back onto the Isocom
12. four Philips head screws from the base of the Printer PCB Check the DIP switch setting on the original printer make sure that the replacement printer is set the same way SEE BELOW ON 1234567 It may be necessary to retain the paper tear bar from the original printer Compare the new printer with the original printer The paper tear bar is a stainless steel strap that runs across the top of the printer mechanism and snaps into the frame To remove it simply lift it off of the frame and transfer it to the new printer Note It may be necessary to pry the frame gently to be able to snap the bar into the frame Next pull the bail bar forward and insert the bar into the slot in the cover The four mounting holes in the Printer PCB should line up with the standoffs Install the four mounting screws NOTE The ground lug from the Printer PCB must be installed on one of the mounting screws Connect the printer to the printer harness NOTE The printer PCB has contacts on only one side check to insure that the contacts line up with the wires of the printer harness MAIN PCB REMOVAL REPLACEMENT Turn the Isocomp off and remove the power cord from the wall receptacle Remove the Top Cover and Front Panel as described on Page 2 3 Disconnect all harnesses from the Main PCB connectors Remove 7 Screws from the MAIN PCB and 5 from the heatsink The MAIN PCB can now be removed If you are replacing the Main PCB compare the replace
13. gram to use proper isotope Page 14 of 24 ISOCOMP I SERVICE MANUAL TEST POINTS Test points are located in the middle of the main board just forward of the heat sink There are 6 test points for the voltages which run the instrument They are as follows TEST POINT FUNCTION TP 1 GROUND TP 2 45VDC TP 3 12VDC TP 4 12VDC TP 5 8VDC DAC REF TP 6 HIGH VOLTAGE When checking the high voltage use caution Voltage is typically at or above 600VDC It is recommended that the voltmeter be set to the proper range and connected to prior to applying power to the instrument If the voltmeter is connected with power applied arcing may occur which will cause the ISOCOMP to lock up and require the operator to turn the power off to clear this condition COVER REMOVAL Tools required 1 point Philips screwdriver Turn the instrument off and remove the power cord from the wall receptacle Using the screwdriver remove the four screws located two on either side of the instrument ISOCOMP I SIDE VIEW REMOVE THESE SCREWS Lift the rear portion of the cover and slide the cover toward the rear of the instrument Note The printer harness will not permit total removal of the cover There is however enough slack in the harness to permit access to the inside with out complete removal Locate the four flat head screws two on either side which secure the front panel to the base Remove the four screws Page 15 of 24 ISOCOMP
14. has failed See below I SOCOMP QA PROCEDURE SERIAL 105000 DETECTOR CALI BRATI CALI BRATI ON FAILED BACKGROUND COUNT This would indicate a possible problem with the instrument Another possibility is that the calibration was performed without a source in the well It is recommended that the rest of the calibration routine be aborted and a new calibration routine initiated Page 8 of 24 ISOCOMP I SERVICE MANUAL SAMPLE PRINTOUT The following protocol can be programmed to provide a sample printout to check the operation of the microprocessor and printer in the ISOCOMP I Press the PROG key and asign a number to the sample protocol For this example we use Protocol 1 From the Main Menu press 1 ENTER The following menu appears Press 5 ENTER The following Menu appears Press 1 Enter The following Menu appears Press 1 ENTER The following Menu appears Press 1 Enter The following Menu appears Page 9 of 24 ISOCOMP I SERVICE MANUAL Press 1 ENTER The following Menu appears Press 1 ENTER the following Menu appears Press 1 ENTER The following Menu is displayed Press 1 ENTER The following Menu is displayed Press ENTER The following Menu is displayed Press 3 ENTER The following is displayed Page 10 of 24 ISOCOMP I SERVICE MANUAL Press 3 ENTER The following is displayed Press 11 ENTER The following is displaye
15. ions such as a B12 Folate assay Instrument calibration is performed automatically by the internal microprocessor and results are printed by the on board thermal graphics printer A calibration standard is required to perform instrument calibration and is available through MGM Instruments The ISOCOMP I is operated either via the 20 key multi function keypad on the front panel or remotely by a computer or terminal utilizing the RS 232 Serial Interface Results are reported via the 20 character vacuum florescent display on the front panel the 20 column graphics printer or through the RS232 interface Specifications Detector 1 5 x 1 5 Nal thallium doped crystal 125 I Efficiency gt 75 Isotope Windows 1351 20 to 75 Kev 100 to 200 Kev Crossover of 57CO 2396 at 0 038 n Ci of 57CO into 1251 window Background 125 Less than 100 CPM Less than 200 CPM Vial Size Up to 16 mm diameter Page 3 of 24 Power Reguirements Operating Temperature Dimensions Weight Front Panel Controls ISOCOMP I SERVICE MANUAL 120 TO 240 VAC Selectable 50 or 60 Hz 410 to 40 degrees 50 to 105 degrees F Height 4 Width 15 Depth 11 24 Pounds The ISOCOMP is controlled by function keys located to the right of the numeric keys on the Front Panel Keypad Function Keys COUNT INITIATES A COUNT SEQUENCE STAT INTERRUPTS A CURRENT PROTOCOL TO RUN A STAT ASSAY RESUME RESUMES INTERRUPTED PROTOCOL
16. ly PCB REMOVAL REPLACEMENT OF PREAMP Turn the power off to the instrument and remove the power cord from the wall socket Remove the Top Cover as described on page 2 3 Disconnect the Preamp Power and Signal Harness and the Preamp High Voltage Harness from the Main PCB Remove the two screws holding the Preamp Screen to the Mounting Bracket From the bottom of the instrument remove the two 8 Philips head screws that secure the Preamp Bracket Page 19 of 24 ISOCOMP I SERVICE MANUAL Gently wiggle the Preamp back and forth while pulling away from the lead block to remove it from the pins of the detector Once the Preamp is free of the detector it can be lifted straight up and removed If necessary remove the Preamp from the mounting brackets by loosening the two clips on the mounting bracket using a 5 16 wrench preferably open end NOTE The nuts do not have to be completely removed if they are sufficiently loosened the Preamp can be rotated and removed from the bracket PREAMP BRACKET PREAMP MOUNTING CLIP HEXNUT PREAMP Install the replacement PREAMP onto the mounting bracket 1 necessary positioned such that the wires of the PREAMP face the Top Cover The clips on the mounting bracket should be placed over the tabs of the Preamp Socket Do not tighten the Clips at this time Install the replacement Preamp onto the pins of the detector Line up the notch in the PREAMP socket with the key on the det
17. ment PCB to the original PCB to make sure that all of the IC s are present Install the Replacement PCB Replace the 7 screws into the clearance holes in the Main PCB Replace the 5 screws into the heatsink Page 18 of 24 ISOCOMP I SERVICE MANUAL Connect all harnesses to the Main PCB as listed below 1 1 RS 232 1 2 Printer J 3 Keyboard Ribbon J 4 Preamp Signal Power J 6 Preamp High Voltage J 7 ACIn J 8 Display Data J 9 Display Power 5 and Ground Reassemble the Front Panel and Top Cover without screwing the covers down Plug the instrument in and apply power to it to make sure that the replacement PCB is functioning properly When it has been determined that the PCB is functional remove the top cover and secure the Front Panel with the four flat head screws Replace the Top Cover and secure it using the four Philips head screws REMOVAL REPLACEMENT OF PRINTER POWER SUPPLY Turn the instrument off and remove the power cord from the wall receptacle Remove the Top Cover as described on page 2 3 Disconnect the AC Harness and the printer harness from the two connectors on the Printer Power Supply PCB Remove the four screws securing the Printer Power Supply PCB Remove the Printer Power Supply PCB Install the replacement Printer Power Supply Position it such that the two harness connectors are facing the Main PCB Connect the Ac Harness and the Printer Harness to their respective headers on the Printer Power Supp
18. p Restore power to the Isocomp Run a calibration of the instrument to assure proper operation of the replacement detector If the instrument is operating satisfactorily remove power once again and secure the Front Panel and Top cover Page 21 of 24 ta Xi m mE buy mE v HA4905 bi b Li ix LU eer asy 1 zom n V s ure i u 2 5 Ha 2 26 25 v ena f 25 i A 4 jn 12 atm beg HI s o jw amp i i i c x dr UF i 3 ses e
19. sonnel only Symptom No response at power up Power up OK No response from the keypad High background counts Low Efficiency No response from printer Printer feeds blank paper Invalid Protocol displayed Zero counts Possible Cause Power cord not plugged in Blown fuse Incorrect line voltage setting Missing 45V Keypad ribbon cable loose Bad ribbon cable Bad keypad Contaminated well liner Contaminated well Contaminated workbench Reagents stored too close Bad detector Incorrect source activity entered during calibration Bad detector Loose printer harness Bad printer power supply Bad printer Paper installed incorrectly Bail bar pulled back Bad printhead Incorrect protocol number entered Memory erased Incorrect count time High background value Incorrect isotope selected Action Check both ends of power cord Replace fuses Check line voltage setting Check TP2 on Main PCB Check both ends of ribbon cable Replace ribbon cable Replace keypad Remove and decontaminate well liner Decontaminate well Clean work bench Move reagents or instrument Replace detector Enter the Simulated activity written on the tube Replace detector Check connections Replace printer power supply Replace printer Turn paper over treated on one side Push bail bar toward rear of Isocomp Replace printer Restart protocol Re enter protocol restart Reprogram Disable background subtract Repro
20. the efficiency test Press 1 to perform the efficiency test If 1 is pressed the following is displayed Enter the activity of the calibration source If the source was purchased from MGM there will be two numbers printed on the label on the tube Enter the SIMULATED activity as is printed on the label Simulated Contains ENTER THIS NUMBER The following will be displayed The instrument will perform 10 1 minute counts of the calibration source After the last tube has been counted the printer will report the average counts efficiency chi2 and report that efficiency is complete The display will return to the main menu and the instrument is ready to be operated Page 6 of 24 ISOCOMP I SERVICE MANUAL NOTE It is recommended that calibration be performed weekly and the printouts saved to be able to track the performance of the instrument SOCOMP QA PROCEDURE SERIAL 105000 DETECTOR CALI BRATI CAL NUMBER 107 BACKGROUND COUNT 1125 C057 49 13 39 65 41 62 51 63 51 78 43 65 48 69 41 15 26 BACKGROUND COMPLETE SAMPLE PRINTOUT EFFICIENCY TEST 199 OF CALIBRATION 62313 62748 62242 62985 62589 62441 62782 62847 62731 EFFICIENCY 80 7 CH 2 z 10 1 EFFICIENCY COMPLETE QA TEST COMPLETE Page 7 of 24 ISOCOMP I SERVICE MANUAL Should calibration fail the printout will alert the user that the calibration
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