幹細胞研究 - コスモ・バイオ
Contents
1. a AFP ES Oct 3 42. Cosmo Bio News No 49 1 embryonic stem cell ES ES
3. 5 1 2002 ES in utro 4 ES ES
4. vitro SCR 2
5. HGF FGF 1 FGF SCF LIF 1 1 18 19
6. NeuroCyte W ready to use euroCyte 140C TF FGF ECM 1007 M 0 296FBS 100m2 Neural stem cell Kit Rat Neural stem cell Kit Human Coming Soon he ON 1 2 3 37C 37C 20 3 59 CO0s 37C
7. ES ES ES ES ES ES ES
8. 1 ES ES 2 15 G0 MACS FACS ES ES EDTA
9. 1 135 0016 2 2 20 URL http www cosmobio co jp Tel 03 5632 9610 03 5632 9620 Fax 03 5632 9619 Nlel AA eC Jle de Cosmd3io News 49 ui i cece 1 X oo oo 4 ES EE NERRRRERIIISIISNS8NWT II IEEE8I S8 m 6 _ SSK SA EE SO 7 NeuroCyte 7 StemChip oe 8 I Nanoc PR amp
10. 2096 tosyl gly DrO IyS PpNA p oNA pNA 405nm Tryptase Activity of Basophilic Cell Lysates KU812 E RBL 8 0 5 0 4 803 EE
11. 2 1 H4 KG20 DNA CrD DNA Sanders DNA H3 53BP 1 tudor Huyen Walworth CrD
12. ProMax BioMag BioMag ProMax 30 5 ProMax rr ProMax 7 ProMax SDS PAGE
13. ES uPA SCID 4 2 1992
14. 2 Cosmo Bio News No 49 Cosmo Bio News No 49 3 TX WES LIF ES ES Thromb X TX WES LIF 129 ES ES TX WES TX WES Medium MG amp M16 8
15. 1 MATGAN ES MATPOA 7 2 6 a MI2
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17. E18 E18 NeuroCyte FGF vitro in vivo ECM vitro
18. a SHT EY 3 1 SRT 10 3 1 EY 109 24 Cosmo Bio News No 49 Cosmo Bio News No 49
19. 1 es MAT1A CpG MAT MAT1A CgpG MAT 14 NT
20. http www cosmobio co jp company tools cbtools top asp 005 D 5 1 0 78 3 22 24 5005 3 29 30 94 94 Zymed s Spotlight CISH simultaneous assessment of gene status and tissue morphology using light microscope Louise Yau Shah Vice President Zymed Laboratories Inc 8005 4 14 12 45 13 45 D
21. SDS PAGE L IPeX IPeX Kit IPeX IPeX refill Kit IFeX Schematic PTgkpcgl A IPeX x rt A WF 4 0 B C T 10x OE D IL EE E F i 1 IL 1 eh Gene Bio Application Ltd 6BA IP 2 2 DreD 9 600 IP 10 10 prep 41 800 IPR 100 1 kit 28 200 ProMax ee 30
22. 0 400cells 0 3 1000cells u2g 5 90 EDTA 1 HE FE ITEEATI 10X 10X
23. 1 HPLC 5096 1 Cibacron blue
24. Rho GTP Rho Rho Rho W Rho Rho Activation Assay Kit GTP Rho Rho 30 100X GTP yS 10mM 100X GDP 100mM Mg 5X Anti Rho A B C 55 GTP Rho
25. 8g004 g8005 ES SCRO0 1 ES ES SCRO02 ES 6 re ES SCR003 SCR004 ES Accumax amp Accutase SCR005 SCR006 http www cosmobio co jp product product CMN_20041214 asp ESGRO ESGRO ES LIF ES 0 22um
26. 3 1 ES MEF LIF leukemia inhiDitory factor ESGRO9 ES MEF LIF ES 1 ES
27. R amp D 8005 RSD GT 82004 R amp D 005 GT 2005 2 2005 SCB 5 000 16 000 siRNA 3 000 ChIP 2005 3 O 2005
28. Vishva Dixit Paul Greengard 003 1 Randall Moon Solomon Snyder Eric Vivier Nancy Walworth Solomon Snyder 1 Stanley Korsmeyer Bcl 6 2004 BH3death
29. 79000 Ey i 74507 1 5m8 132 45 000 12 17mm 74550 12mm X55mm 44 180 000 16mm X100mm 16 1213mm 74551 1 5 40 170 000 12mm X75mm 100 28mm 74552 1 5m6 32 160 000 28mm X115mm 12 74619 96 4 140 000 2 DNA 74629 1 5M 60 45 000 0 5m 72 HH 12mm 110 230 000 74858 13mm 110 230 000 74914 16mm 69 230 000 74963 15m2
30. Walensky BH3 Randall Moon Vishva Dixit EGFR Snyder EGFH Bcl 9
31. IgA SDS PAGE 5 KAPTIV AE 8 0 1MU pH7 0 1 m2 min IgA a 0 1 M gt 9096 ELISA Crude crude Peak 1 Peak2 KAPTIV AE lgA Technogen s c p a Parco Scientifico Te KAPTIV AE TG9000 2 9 67 000 TG9001 5 my 133 000 TG9002 10 mg 324 000 KAPTIV GY MSN Human lgG1 IgG2 IgG3 IgG4 IgG lgY mm 19G1 19G2 19G3 1 R DDI d 10g lgG m2 50mg lgY m6 lgG G00cm Sheep lgG1 IgG2 Highly cross linked Rat lgG2a IgG2b 2 2 Mouse lgG2a IgG2b IgG1 bls acrylamide azlactone CoOpolymer Pig lgG
32. Related Resources Eqditorial Guides E M Adler N R Gough L B Ray 2003 Signaling breakthroughs of the year So STKE 2004 eg1 2004 E M Adler N R Gough L B Ray 2002 Signaling breakthroughs of the year Sci STKE 2003 eg1 2003 Reviews Galli and V Haucke Cycling of synaptic vesicles How far How fast Sci STKE 2004 re19 2004 J C Reed K S Doctor A Godzik The domains of apoptosis A genomics perspective Scl STKE 2004 re9 2004 This Week in ST Toward tailored cancer therapy Sci STKE 2004 tw210 2004 Stayinl alive Sci STKE 2004 tw304 2004 Sending a cell death sentence Sci STKE 2004 tw319 2004 Organizing synapses Scl STKE 2004 tw441 2004 The missing link Sci STKE 2004 twe9 2004 Connections Maps J Schlessinger Epidermal growth factor receptor pathway Scl STKE Connections Map as seen January 2005 http stke sciencemag org cgi cm stkecm CMP_14987 F Vely E Vivier Natural killer cell receptor signaling pathway Sci STKE Connections Map as seen January 2005 http stke sciencemag org cgi cm stkecm CMP_13625 F Vely E Vivier Natural killer cell receptor signaling pathway in mammals Sci STKE Connections Map as seen January 2005 http stke sciencemag org cgi cm stkecm CMP_14358 References Tl T J Lynch D W Bell R So
33. 1998 real clone 1 1998 11 ES ES 1981 ES 2 1999
34. 1 500 90 70 70 10 9 DI 4
35. Umemori FGF2 Greengard Solomon Snyder CAMP erman Kolodkin Terman Kolodkin A AKAP Drosophila Nervy CcAMP A PKA
36. 1 X PE http www cosmobio co jp product product THX 20030919 asp 4 Cosmo Bio News No 49 Cosmo Bio News No 49 5 ES ES ES 19 ES SCID ES
37. http www cosmobio co jp product product BCH 20041025 asp 0 DNA RNA 50 10m2 x 1 DNA RNA MORE EXTRACT kwGMiig 2Om2 x 1 SDS 10m2 x 1 RNase 10M Xx 1 2 50 1 MORE EXTRACT DNA KYO Aeromonas hydrophilia GTC 140 Escherichia coli GTC 1061 Salmonella enterica GTC 133 Staphylococcus aureus GTC 1186 Listeria monocytogenes GTC 149 Bacillus cereus GIF
38. 4 2 37C 5 3 5 5 37C i i 1 3 8 I GFAP Tujl tubulin GFAP GFAP 5 MBP Orion Biosolutions Inc
39. 0 2 01 a KU812 RBL 0 Ca A23187 Non Treated A2318 A2318 97C 1 500nm 500nm Protamine 37C 98 x Ca A23187 tosyl gly pro lys pNA ppNA xX 1 0 10 0x108cells m2 1 0 Ca 10u6 1 0 500nM 10 1 0 100uM 37C 1 5 C0e
40. AAF 3096 1 Y situ ES 3 ES 1998 ES ES ES ES
41. a 700Xg 8C b 700Xg cold PBS 1 1 X 8C Chemicon International Inc MNM Mast Cell Degranulation Assay Kit IMMOO01 96assay 93 000
42. es ER ES BECI Nanog Human Mause Monkey RCAB0001P 200 0 2 7g 7 54 000 8 Cosmo Bio News No 49 New Products amp IODICS 9 amp Rho Rho G 20 30kDa MAP JNK p38 1 GTPase
43. 5 Diff Quik G0X 60X Chemicon International Inc MNI Eosinophil Isolation IMM002 25 assay 56 000 10 Cosmo Bio News No 49 Cosmo Bio News No 49 11 amp 3 KAPTIV AE GY M Pu 80
44. DINA RNA Protein DNA RNA Dr P Kit Dr P Kit 1 Dr P Kit 2 Dr P Kit 3 1 2 3 0 5 SDS DEPC 0 1mM EDTA TE RNase 10g 10096 amp 7096 1 Dr P DNA 2 Dr P HNA 3 Dr P SDS PAGE Be CB K2021010 75 000 CB K2021010 1 50 ml 32 000 CB K2021010 2 6 md 15 000 CB K2021010 3 14 ml 17 000 BioChain Institute Inc
45. 4 ES A 1 1 FT i FmPd E 1 uu Ff KepraCEl LL ES 1 bi 1 RM 5096 1096 ES Er TT ER nlL rT I ri a ee 1 IFPr 11 B Fi ES WT 10 DMSO Ft 4 ES MM a
46. RPMI AS B I DH9 5 lt XM 199 SSEA lt xDMEM SSEA 5 lt PBS a re ES jn vitro ES ES SSEA 1 4 A A ES MBL 5 B ES MBL 5 ESGRHO 10 LIF ESGRO 10 Chemicon International Inc MN ES 3D ESCell 3D Culture Kit SCR003 100 test 123 000 Saw 8 1 chemicon International Inc ee FE Es nS
47. 80C P20C 1 Thromb X N V MX 27 000 40 000 250 my 500 mk M2 M HEPES modified Krebs Hinger Quinn et al 1982 HEPES pH M1 6 M16 596 CO0s jn vitro modified Krebs Ringer Thromb X N V MX M2 M2 Mouse Embryo Medium M16 M16 Mouse Embryo Medium TX MEM 01 100 mg 9 400 TX MEM 02 100 mg 9 400 ES ES ES
48. CDNA RNA CDNA BioArray GeneBeam cDNA Cyanine 3 dUTP Cyanine 5 dUTP Human Cell log phase 1 5mm 7 5x 1 08 29
49. ES TX WES 8 ES 1 1 ES EET 2 pm TT 0 ES 45 mg 20C RCHETP001 3X15 mg 24 000 0 5x 1 06cells vial ES 25 mb 0 MEM 1 22 000 MAP ES TX WES gg 0 Thromb X N
50. 1 AFP Cyp 7a 1 ES ES
51. DNA C3 15 15 18 Cosmo Bio News No 49 Cosmo Bio News No 49 19 ACADM ILPIP S100A4 ILPIP TRIM5y TRIM5o SARS M SARS E active pro CasDase 3 Activin Receptor type ll ADCY3 ADCY7 Adenovirus Fiber monomer and trimer Adipolean Variant AGAP1 Ago2 AIRE AKIP a 1 Spectrin P
52. en p04 oDD5 CONTENTS March 2005 Cosmo_io X ES ES IE 1 4 m NeuroCyte StemChip KAPTIV AE GY M IPeX DNA RNA MORE EXTRACT DNA MOZAIC s 2005 3 1
53. PI 4 5 P PI 4 5 Ps Greengard Sanes 2 1 Nishimune
54. ESG1106 ESG1107 ESG2206 ESG2207 Csscm SNews DNA 5SK 3 IX BIO Wnt bis indolo BIO ATP 3 GSK 3 o ICP9 50nM MAP PKA PKC PKG CK IRTK ICO 10 M Cdk Cdk5 p25 Cdk 2 A Cdk1 B Cdk4 D 1 ICP9 893 300 380 10 000nM BIDU GSK 3 Wnt
55. 20 Cosmo Bio News No 49 Cosmo Bio News No 49 21 1 AAAS CIENCE 2004 Science AAAS American Association for the Advancement of Science STIKE STKE STKE 2005 Breakthroughs of the year 2004 AAAS 004 Elizabeth M Adler Nancy R Gough and L Bryan Ray3 Associate Editor of Science s STKE American Assooiation for the Advancement of Science 1200 New York Avenue N W Washington DC 20005 USA 2 Managing Editor of Science s STKE American Assooiation for the Advancement of Science 12500 New York Avenue N W Washington DC 20005 USA 3 Editor of Sci
56. ES ES ES ES 4 1999 Petersen
57. RIPA 2 1 80 1 60 3 3 non SDecific non SDecific 100 phospho p38 100 phospho p38 0 01 non phosphorylated p38 3 non phosphorylated ERK Assay Designs Inc AS T 900 101 96 well 111 000 900 102 96 well 111 000 TiterZyme Immunoassay http www cosmobio co jp product product ASD 20050120 asp p me
58. 96 100 pk 400 pk Closed HXWXD Open 51 X 82 XX 60 cm 46 kg 1 a anti Chromogranin A 3 Zymed Laboratories Inc Z2YMI MOZAIC Automated Immunostainer Closed System 76 1030 1 MOZAIC Automated Immunostainer Open System 76 1031 1 MOZAIC Histostain LAB SA DAB Detection Kit 76 9643 110 mg MOZAIC Histostain LAB SA AEC Detection Kit 76 9943 110 mg MOZAIC SuperPicTure DAB Detection Kit 76 9683 110 mg MOZAIC SuperPicTure AEC Detection Kit 76 9983 110 mg
59. ES FS 2003 1 16587 2003368162 2003 37758 ES ES ave eC de 1 ES
60. Akt STAT 5 KS DNA Sordella Dixit Nancy Walworth DNA
61. ES LIF MEF GSK 3 Inhibitor IX BIO 2 Z 3 E 6 Bromoindirubin 3 oxime GSK 3 Inhibitor IX in Solution BIO 2 Z 3 6 Bromoindirubin 3 oxime e CALBIOCHEM ES ES BIO Polychronopoulos P et al 2004 J Med Chem 47 935 sato N et al 2004 Nat Med 10 55 Meijer L et gal 2003 Chem Biol 10 1255 2004 Vol 22 No 7 BIO EMD Bioscience Inc Former Calbiochem BO 361552 500 g 13 800 361550 1 mg 20 700 NeuroCyte RIGOn ready tO use
62. 50 80um Horse lgG Goat lgG1 IgG2 Chicken lgY Ir KAPTIV GY lgY SDS PAGE 5m2g KAPTIV GY 2m2 50mM Bis TrisS pH6 5 m2 min IgEY 0 1M A Ccrude B KAPTIV GY IlgY EE C KAPTIV GY KAPTIV GY KAPTIV M 85 lgM 10mg lgM m2 750cm 496 Highly cross linked Agarose 45 165 um KAPTIV M Technogen s c p a Parco Scientifico ICM TG10000 67 000 TG10001 133 000 a KAPTIV M IgM SDS PAGE 1 m2 KAPTIV M 2m2
63. 83 4 1 StemChip StemChip WV rNSC Nestin Vimentin Prominin CD133 Sonic hedgehog Wnt 3A Neurocan tenascin C Nurr 1 Pax 6 Sox 2 Musashi 1 NG2 CSPG 4 Neuro D3 Neurogenin 1 3 CNTF BDNF GDNF 16 Ptubulin I MAP2 Neuron specific enolase NCAM CD24 HSA SynapSin Synaptophysin CAMK lla Tyrosine hydroxylase Glutamate transporter Glutamate receptor Choline rec nicotinic A2 EphB2 GABA A receptor Serotonin 5HT 3 receptor Choline acetyltransferase GFAP GAD65 S100 3 Olig1 Plp DM20 Myelin basic protein Presenilin 1 Pp APP Bcl 2 Huntington s disease protein 3 GAPDH PB actin Lamin A Hat1 Hat5 YBBR Orion Biosolutions Inc BS Neural Stem Cell Focused Microarray 01028 1 kit 109 000 Neural Stem Cell Focused Microarray Human Coming Soon 01029 1 kit 2 N
64. ES LIF ES ES Oct3 4 Nanog ES Wnt 8 catenin Wnt3a ES GSK 3 indirubin BIO 6 bromoindirubin 3 oxim ES ES 2003 ES ES ES
65. LAT ITAM LAB Vivier 22 Cosmo Bio News No 49 Cosmo Bio News No 49 23 S005 STKE STKE
66. 10 BD 1 BD BD D BD BD TC 005 2004
67. PersDeCtiVe8 Reviews This Week in Signal Transduction Summary 6 10 Original Protocol Editorial Guides STKE Connections Maps BMNNUD Signaling database Highlights and Related Resources i MyRun 1 EE EE S0
68. 6 350 1 300 a Cell Culture Drug Discovery 82005 UBI i 2005 G CDNA Tag siRNA
69. 182 p38 MAP P38 p38 Enzyme Immunometric Assay EIA phospho p38 MAP Kinase ELISA Total p38 MAP Kinase ELISA CG 5S ww erERRTT TMB HRP RIPA p38 900 101 p38 900 102 156 5 000 pg mk 78 5 000 pg 2 100 pk 100 pk 40 in duplicate 39 in duplicate 52 1 pg mk 15 6 pg mk 6 8 13 8 Intra 2 6 7 6 Intra 6 9 12 19 Inter 2 3 6 396 Inter RIPA
70. PT 101 89 lt 6 000 TP DNA 1 600m8 78100 DNA 0 5m 1 5m2 X60 138 78100 55C 78110 85C 74600 78120
71. 69 230 000 74964 28mm 26 230 000 74945 600 9 8 140 000 1709 8 45 000 AMI DNA 1725rpom W35XD47XH28cm 100V 15A 42kg 78100 1 set 1 090 000 650 000 16 Cosmo Bio News No 49 Cosmo Bio News No 49 17 amp TS MOZAIC 2 3B6 3 1 1 8 Mozaic Open Closed
72. A SDS PAGE 1 2 3 ProMax 3 B 1 ProMax 3 Anti HRP Polysciences Inc PS ProMax ProMax Albumin Removal Kit 12 Cosmo Bio News No 49 Cosmo Bio News No 49 13 DNA RNA Dr i Institute In DNAZRNA DNA RNA Dr P
73. ITAM DAP10 GEF Cella ITAM GEF Vav Vav3 DAP10 Vav 1 KARAP DAP125 DAP10 ERK 1 ERK ITAM Vivier TAM NK Vivier BB LAB NTAL Zhu 5
74. 2 100g 80g 165nm 127nm Electoromotion Mixer PTA 100V 3 000 13 000rpm DONCIDITR ON lo PT 101 3M 1 5m2 400 9 1 59 lo 0 5 0 3 PCTFE AD 3528 2 3 600
75. IHC Closed Open TL Ee FE re Fr nnh orke ne Finzbi Emgrr Kaik 1 1 5 Tragg Egrere Eke J WWcnr Eramml beepgh Hiki rmmt rr oa TT kg HH FlssnrTaski bar nm mf Facrh EYNMED LABORATORIES INC vancin g Science amp Medicine Through Immunochemistry Mozaic SuperPicTure Histostain LAB SA labeled biotin streptavidin 2 HC CISH Chromogenic In Situ Hybridization IHC 96 12 X8 48 3
76. BSM 4 Tuj 8 tubulin II GFAP 01024 1 kit 161 000 01025 1 kit 6 Cosmo Bio News No 49 Cosmo Bio News No 49 7 F Sb5X X 7 5mm 42 4 3
77. HR CE SC EE CE 19 ee 20 STKE 2004 22 3 8cm SS 2 5 i a
78. Pietro De Camillili 4 5 PI 4 5 Ps PI 4 5 Ps Greengard PI 4 5 Pae Di Paolo
79. Rhotekin RBD agarose i Fa 414 GTP yS 1 3T3 bg a Rho GTP Rho RhoA Upstate Inc UB 127 000 G Ras Rac ccd42 Rap 1 Ral Ei 20 aka4 4mle724 A A AerelaleelleMee 4aelelllex74elgele 9 ei 6 46 9 2 61s121sW 19 p38 ES EIA TiterZyme lmmunoassay MAP ERK JNK p38 p38 MAP MKK3 180
80. A cAMP 9 Snyder cAMP CAMP Eric Vivier 3 1 Terman Kolodkin Vivier Koga
81. 19 5 HGF NOD SCID AAF 309 55
82. 4A6 A Upstate Inc UB _ HE Anti Myc Tag Mouse IgG1 4A6 WB IB IP 60 000 Anti Myc Tag Mouse IgG1 4A6 IB IC IP 276 000 Anti Myc Tag biotin conjugate Mouse lgG1 4A6 IB IC 58 000 Anti Myc Tag HRP conjugate Mouse lgG1 4A6 IB IC 58 000 http www cosmobio co jp product product UBI 20050201 asp 0 p uid 7 1 1 5 0 5 M 23M rpm 9 000 9 000 CCW CCW 3 2 4
83. Tassiulas KARAP 1 kD DNAX DAP18 ITAM KARAP DAP15 Tall Fc g FcRg ITAM ga STAT 1 09 Vivier Vivier NK
84. Rho Upstate Inc UBI 10 p38 EIA Assay Designs Inc ASD Chemicon International Inc CMN 11 Chemicon International Inc CMN KAPTIV AE GY M Technogen s c p a Parco Scientifico TCG 12 IPeX Gene Bio Application Ltd GBA 13 ProMax Polysciences Inc PGI DNARNA Dr BCH 4 DNA HNA MORE EXTRACT KYO cDNA GeneBeam Enzo Life Sciences Inc ENZ 15 Human Cell Prosci Inc PSC 15 WW Spring Bioscience SBS 16 Myc tag 4A6 Upstate Inc UBI ISO 17 DNA AHL MOZAIC Zymed Laboratories Inc ZYM 18
85. 34 000 73 000 Fibrinogen Receptor FNTA Ctr FNTB N term GABAA Receptor assoclated protein like 2 GABARAPL2 GC B 1 3 GCS1 N term GFAP 1 GFRa 2 GDNFRb GFRa 3 GDNFRg GGPS1 C term Ghrelin motilin related peptide mouse C terminus GJA3 N term GJA5 N term GJAT7 N term GLEPP1 Ctr Glycogen Synthase Ser640 Phospho Specific Goa GPCR GPR15 GPI8 N term GPIP137 C term GPLD1 N term GPLD2 N term GPRC1F C term GPRC1G C term GRK7 C term HAPIP C term hDSS1 N term Heat Shock 90kD protein 1 alpha HSPCA Heat shock transcripton factor 2 binding protein HSF2BP HIP2 Ctr Hippocalcin Ctr Histone H2A T126 Phospho specific HSF1 Sumoylation site HSF2 Sumoylation site 5HT1D Receptor 5HT3 Receptor IGSF4 IKBa Sumoylation site ILT2 ILT4 Influenza A N2 N3 specific Insulin like Growth Factor Binding Protein 6 ITCH N term KLF6 LAF4 C term Laminin B2 y 1 LEPR N term LOC130337 C term LRP15 C term LyPTP N term MAGEA8 N term MAGEA9 Ctr MAGEA10 C term MAGEA11 N term MAGEA12 N term MAGED1 Ctr MAGEE1 N term MAGEF1 N term MAGEH1 N term MAGEL1 N term MAP4K2 Center MDMA MEF2A MEG1 Ctr MEG2 C term metabotropic Glutamate Receptor 6 7 METAP1 N term MIB Ctr MJD C term MLC 2V MLP N term MSF C term Mu Opioid Receptor Myb Sumoylation site NCE2 C term NDK8 C term Nematode SUMO N term Neural stem cell derived neuronal survival protein SDNSF Neuropeptide YY PYY Peptide tyrosine tyrosine ADI ABG AB
86. 50 g 100 Lg 100 pk 100 Lg 0 1 mg 0 1 mg 0 1 mg 100 Lg 50 g 100 Lg 50 g 50 g 0 1 mg 100 Lg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 7 mg 10 BLOT 0 1 mg 7 mg 100 Lg 0 1 mg 0 1 mg 0 1 mg 50 g 100 Lug 0 1 mg 0 1 mg 0 1 mg 50 g 100 Lg 0 1 mg 200 pk 100 Lg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 500 Lg 100 pk 50 pk 0 1 mg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 500 Lg 100 Lg 100 Lug 200 Lg 500 Lg 100 Lg 100 Lug 0 1 mg 0 1 mg 0 1 mg 100 Lg 100 Lg 50 g 50 g 100 Lg 0 1 mg 500 Lg 100 Lg 0 1 mg 0 1 mg 50 pk 0 1 mg 71 000 71 000 44 000 44 000 87 000 34 000 34 000 34 000 73 000 78 000 26 000 71 000 71 000 34 000 73 000 34 000 34 000 34 000 34 000 34 000 34 000 34 000 71 000 72 000 57 000 71 000 105 000 34 000 34 000 34 000 78 000 135 000 34 000 34 000 34 000 88 000 71 000 34 000 47 000 55 000 57 000 34 000 34 000 34 000 60 000 58 000 28 000 34 000 34 000 34 000 34 000 34 000 34 000 34 000 34 000 34 000 34 000 44 000 73 000 135 000 53 000 60 000 154 000 135 000 34 000 34 000 34 000 62 000 62 000 71 000 71 000 87 000 57 000 79 000 73 000 34 000 34 000 71 000 34 000
87. Nature 432 406 411 20024 G Di Paolo H S Moskowitz K Gipson M R Wenk S Voronov M 0bayashi R Flavell R M Fitzsimonds T A Ryan P De Camilli Impaired PtdIns 4 5 P Synthesis in nerve terminals produces defects in Synaptic vesicle trafficking Nature43 415 422 2004 8 H Nishimune J R Sanes 8 S Carlson A synaptic laminin calcium channel interaction OrganiZes aotive zones In motor nerve terminals Nature 432 580 58 20024 9 H Umemori M W Linhoff D M Ornitz J R Sanes FGF22 and its close relativeS are presynaptic organizing molecules in the mammalian brain Cell1 18 557 70 20024 10 J R Terman A L Kolodkin Nervy Iinks protein kinase A to plexin mediated semaphorin repulsion Science303 1504 18507 20024 11 T Koga M Inui K Inoue S Kim A Suematsu E Kobayashi T Iwata H Ohnishi Matozaki T Kodama T Taniguchi H Takayanagi T Takai Costimulatory SIgnals mediated by the ITAM motif cooperate with RANKL for bone homeostasis Nature458 58 693 20024 Tassiulas X Hu H Ho Y Kashyap P Paik Y Hu C A Lowell L B Ivashkiv Amplification of IFN induced STAT 1 activation and inflammatory function by Syk nd ITAM containing adaptors Nat Immunol 5 1181 1188 2004 13 M Cella K Fujikawa 1 Tassi S Kim K Latinis S Nishi W Yokoyama M Colonna W Swat Differential reauirements for Vav proteins in DAP10 and ITAM mediated
88. 401 A10 100 401 A09 AP8409A AP6258A AP7668A XG 6119 MAB3890 MAB3892 AP8147A AP8146B AP8145A AP8154C AP8136B AP8137A AP8135B AP1354A AB9162 KR097 AP8400A AP2102C AP7730B XG 6122 AP8161A AP2504A AP7097A AB3142 XG 6117 AB16369 AB16387 AB16474 AP2539B AP8151A 07 639 AB16152 AP6231A AP6232A AP2103B AP6304A AP6305A AP6304B AP6260A AP6259A AP2421B AP2173A AP2174B AP6237A AP6238A AP6233A AP6235A AP6236A AP2503A AP2416B BAF2087 AB5515 AB14265 AB14259 AB14260 50 g 0 1 mg 0 1 mg 100 Lg 0 1 mg 0 1 mg 0 1 mg 50 g 0 1 mg 100 g 0 1 mg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 50 pk 50 g 100 Lg 100 g 100 g 100 Lg 100 pk 100 pk 0 1 mg 0 1 mg 0 1 mg 500 Lg 100 pk 100 pk 0 1 mg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 100 g 25 g 0 1 mg 0 1 mg 0 1 mg 500 Lg 0 1 mg 0 1 mg 0 1 mg 500 pk 500 Lg 100 Lg 100 Lg 100 pk 0 1 mg 0 1 mg 200 pk 50 g 0 1 mg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 50 g 200 pk 50 g 50 g 50 g 78 000 34 000 34 000 73 000 34 000 34 000 34 000 88 000 34 000 62 000 34 000 34 000 34 000 34 000 34 000 34 000 71 000 30 000 44 000 44 000 44 000 44 000 44 000 44 000 34 000 34 000 34 000 79 000 116 000 116 000 34 000 34 000 34 000 34 000 34 000 3
89. 6120 AP1633A AP8150B A300 253A MAB8471 38 8800 AB16363 XG 6121 MAB1443 AP2535B AP2536B AP2536A AP2537A AP2417B AP2418A AF2257 100 Lg 100 Lg 7 md 100 Lg 100 Lg 100 Lg 100 Lg 100 Lg 100 Lg 500 pk 100 Lg 100 Lg 500 pk 100 Lg 100 Lg 200 pk 100 Lg 100 Lk 100 pk 100 Lg 200 Lg 200 Lg 500 Lg 0 1 mg 100 Lg 250 Lg 0 1 mg 500 Lg 200 pk 50 pk 50 g 25 g 50 g 50 g 50 g 25 pk 50 pk 0 1 mg 500 Lg 100 Lg 100 pk 100 pk 100 pk 500 Lg 50 g 100 Lk 100 Lg 200 pk 0 1 mg 500 Lg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 100 pk 100 pk 50 g 0 1 mg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 500 Lg 0 1 mg 0 1 mg 0 1 mg 100 g 100 g 100 Lg 500 Lg 100 g 0 1 mg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 100 g 71 000 55 000 41 000 55 000 55 000 55 000 55 000 55 000 71 000 71 000 71 000 71 000 71 000 88 000 47 000 71 000 47 000 47 000 71 000 60 000 58 000 60 000 60 000 57 000 87 000 56 600 57 000 79 000 71 000 71 000 88 000 71 000 71 000 71 000 71 000 71 000 71 000 64 000 79 000 52 000 44 000 71 000 71 000 71 000 71 000 71 000 67 000 71 000 34 000 60 000 34 000 34 000 34 000 34 000 34 000 71 000 44 000 78 000 34 000 34 000 34 000 34 000 34 000 79 000 34 000 34 000 57 000 26 000 64 000 71 000 79 000 50 000 34 000 34 000 34 000 34 000 34 000
90. Ilyengar et al 1983 Me M 16 vitro Whitten s Whitten 1971 4C TX WES 25 TX WES 50 THhirnrmh LF Ready to Use Ja e ES ES ES Balb c FVB ES ES ES
91. PBS 1 m2 min IgM 0 1M pH9 0 gt 859 B C KAPTIV M IgM Technogen s c p a Parco Scientifico M 6 EE TG8000 2 mg 67 000 TG8001 5 mg 133 000 2 p IPeX i 1 9 g 10 700u2 His GST
92. tudor Huyen CrD K 0 Crb2 53BP 1 H4 K20 HG3 K79 DNA DNA 1 1 Paul Greengard 1
93. 0 1M pH2 0 2M pH 0 1M pH9 0 KAPTIV AE IgA IgE 10mg lg m2 750cm 496 Highly cross linked Agarose 45 165 um 0 PBS CAE M CGY TritonX 100 a KAPTIV AE
94. 03 10 i MyRun 20 309 0FF i MyRun N i MyRun N I MyRun NC Ii MyRHun P Oligo GEArry Oligo GEArray 1 17 3 91 Oligo GEArray m GA009 1kit 0 000 Oligo GEArray 1 BD falcon 1 1 3 31 4 15
95. 11 Myc ta 4AG 3 9E10 4A6 9E10 Hii nl MEQKLISEEDL AEEQKLISEEDLLRKRREQLKHKLEQLRNS Myc 41 0 420 Myc IE Fa TarT me lilieilll 408 437 EE A 1 5 a a a Lm 1 4A6 9E10 4A6 9E10 a NIH3T3 10 SDS PAGE ri mm Tg Lg a msiR 1 emm LAT pLPC 1 Hi pLPCmycLRKRGST A SUB MycLRKRGST A PP2A A pLPCmycNGST A SUB MycNGST PP2A A Myc NN mm Pretlrrgpweiurm si mycLRKRGST tagged A subunit MEQKLISEEDLLRKHRGST Met 1 Mc rd whirrt mycNGST tagged A subunit MEQKLISEEDLNGST Met 9E 10
96. 3 p48 DDB2 p127 DDB1 PCPTP1 N term PDAP1 C term PDGFRL C term PDXK 1 Peroxisome Proliferator Activating Receptor o IPPARc Peroxisome Proliferator Activating Receptor B PPAR B PFKFB1 N term PFKFB2 C term PFKFB3 N term PFKFB4 Ctr PFKL C term PFKM N term PFKP C term PHO1 N term Phosphodiesterase 6 6 Phospholipid Scrambrase MIf1 Phospho specific PJA Ctr PKC D2 C term PKNOX1 1 PLAU N term PML Sumoylation site PNCK C term Polio Virus Receptor PPIA3L 3 PPP1B PPP1G1 PPP6C PPT2 C term PRKR N term Prmt7 Prostaglandin E Receptor EP3 5F5 PSEN1 C term PSEN2 N term PSMD4 C term PSN1 C term PSN2 C term PSN1 2 PVR C term PVRL1 C term PXF C term RAD23A N term RAD23B C term RAI1 C term RAI2 C term RAI14 C term RAI16 C term RAI17 C term Ran GTPase Sumoylation site RCE1 N term RcRH5 RFP2 RGS5 RGS13 RGS17 RGSZ2 RSD ABG ABG RSD ABG ABG ABG PSC ABG CMN ABG ABG ABG ABG ABG ABG ACM BVL RKL RKL RKL RKL RKL RKL ABG ABG ABG PSC CMN CMN ABG ABG ABG ABG ABG ABG ABG ABG CMN ABG ABG ABG PSC ABG ABG ABG ACM PSC ACM ACM ACM ABG ABG UBI ACM ABG ABG ABG ABG ABG ABG ABG ABG ABG ABG ABG ABG ABG ABG ABG ABG ABG ABG RSD ACM ACM ACM ACM BAF1235 AP6303A AP1321A AF2249 AP8153B AP2519A AP2520A XP 5247 AP8157B AB5697 AP6222A AP6225A AP6227A AP6228A AP6229A AP6230A AB16584 RD181045050 600 101 285 600 101 284 600 101 286 600 101 283 100
97. 4 000 34 000 34 000 87 000 49 000 34 000 34 000 34 000 79 000 34 000 34 000 34 000 71 000 79 000 71 000 71 000 71 000 34 000 34 000 58 000 71 000 34 000 34 000 34 000 34 000 34 000 34 000 34 000 34 000 34 000 34 000 34 000 34 000 34 000 34 000 34 000 34 000 34 000 34 000 78 000 71 000 71 000 71 000 71 000 RGS18 RGS20 RING1B ROC2 RTP801 hypoxia inducible factor 1 responsive gene SAP1 C term SCDGFB Center SCRATCH1 C term Semaphorin 6C Semaphorin 6D Septata Intestinalis Serotonin N acetyltransferase phospho S206 Serotonin N acetyltransferase phospho T29 SHFM3 C term Siglec 3 SIGLEC3 N term SIGLEC8 C term SiglecL1 N term SIRT3 C term SIRT5 C term SIRT6 C term SIRT7 C term skeletal muscle Actin Smad3 DSpS423 425 SMAR1 BANP smooth muscle Actin SPON1 SPTLC1 C term SPTLC2 N term SQSTM1 C term SR A1 Sra 1 ST5 C term ST7 C term ST13 N term STNF Receptor Il Stromal Antigen 2 SULT4A1b Center SUV420H2 TIRP TOUF FLJ20241 TPIPa C term TPIPb C term TPTEa N term TREM 2b Histone H3 Lys9 Ser10 amp Lys27 Ser28 tmethyHphospho TRPV4 UBCE7IP1 C term UBCE7IP3 N term UBCE7IP4 C term UBCE7IP5 Ctr UbcH7 BP C term Ubiquilin1 N term Ubiguillin3 C term UBQLN3 N term UCHL5 C term UCK N term ULP1 UNC5H1 Uncoating ATPase VAMP Associated Protein A VAPA Vasorin VGAT VGLUT 1 VILIP1 C term VILIP2 C term VILIP3 Ctr VIN 2PB 22 GD2
98. 6 Human Cell Array Human Cell Array II Ready to use 0ligo dT Primer 55u8 5X Reaction Buffer 250A 10X DTT T T1048 Cyanine 3 dUTP Deoxynucleotide Mix 55u8 Cyanine 5 dUTP Deoxynucleotide Mix 55u8 ENZ RT RNase Inhibitor 110 RNase Cocktail 1 10 Nuclease free Water 1 mg Control RNA 8L6 Enzo Life Sciences Inc ENZI 1 kit 50 241 000 25 nmol 52 000 25 nmol 52 000 WEroel Human Cell Array I 17 601 293 kidney transformed with adenovirus 5 DNA A 431 epidermis epidermoid carcinoma A549 lung carcinoma Hela SS cervix adenocarcinoma Hep G2 liver hepatocellular carcinoma NCF breast pleural effusion adenocarcinoma Human Cell Array HI 17 602 WHL 60 promyeloblast acute promyelocytic leukemia Jurkat T lymphocyte acute T cell leukemia K 562 Done marrow chronic myelogenous leukemia NOLT 4 Iymphoblast acute lymphoblastic leukemia Haji B lymphocyte Burkitt s lymphoma HP monocyte acute m
99. G CMN FGI ABG UBI PSC PSC ABG CMN ABG ABG ABG ABG CMN UBI ACM ABG ABG ABG ABG ABG ABG ABG ABG ABG CMN CMN ABG ABG ACM ABG ABG ACM ACM RSD ABG RSD RSD CMN CMN ABG ZYM ABG ACM ABG ABG ABG ABG ABG ABG ABG ABG ABG ABG ABG ABG ABG ABG ABG ARB UBI ABG ABG ACM ABG ABG ABG SPS ABG ABG ACM ABG ABG ABG ABG CMN CMN Anti 323 AP2420A AP2414A AB9130 SGCP 201AP AP2315A 07 650 1135 1137 AP2419B AB9134 AP1543A AP1545A AP1547A AP8403A AB3379 07 634 AB16445 AP2462A AP2463B AP2405A AP2461A AP1642A AP1640A AP7731B AP6120A AP6264A AB9146 AB9140 AP2114C AP1564C ABS3598 AP2501A AP2502A AB13895 AB13897 AF1459 AP2506C BAF2017 BAF2078 MAB8258F AB9148 AP2171A 37 8400 AP6149A AB3297 AP6151A AP1071B AP6152A AP8406A AP6169A AP6170A AP6160A AP6161A AP6162A AP6176A AP6178A AP6179A AP6180A AP6181A AP7065B ABMDM 0402 07 616 AP8407A AP8408B AB15308 AP2319A AP2172C AP2181B 310 011 AP2522A AP6215A AB10572 AP2500A AP1070B AP8159B AP1288A AB9174 AB9170 0 5 mg 0 1 mg 0 1 mg 100 Lg 100 Lg 0 1 mg 100 pk 100 Lg 100 Lg 0 1 mg 100 Lg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 100 Lg 50 g 50 g 0 1 mg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 100 Lg 100 Lg 0 1 mg 0 1 mg 100 pk 0 1 mg 0 1 mg 100 Lg 100 Lg 100 Lg 0 1 mg 50 g 50 g 100 Lg 100 L
100. NK cell cytotoxicity J Exp Med 200 817 8893 2004 14 P Volna P Lebduska L Draberova S Simova P Heneberg M Boubelik V Bugajev B Malissen B S Wilson V Horejsi M Malissen P Draber Negative regulation of mast cell signaling and function by the adaptor LAB NTAL J Exp Med 200 1001 1018 20024 15 M Zhu Y Liu S Koonpaew 0 Granillo W Zhang Positive nd negative regulation Of Fc HImediated signaling by the gdaptor protein LAB NTAL J Exp Med 200 981 1000 2004 My Citation E M Adler N R Gough L B Ray 2004 Signaling breakthroughs of the year Sci STKE 2005 eg1 2005 Year American Association for the Advancement of Science All rights reserved AAASs BET Web STKE Signal Transduction Knowledge Environment Science Web stke STKE STKE STKE http stke sciencemag Org http www cosmobio co jp STKE index html sTKE Protocols
101. P2A methyltransferase PPMT1 p125Nap1 DLG1 Angiopoetin like2 Aprataxin Arrestin 3 ARR3 X arrestin retinal Asialoglycoprotein Receptor AURORA A KINASE BACH1 3 Bcl rambo Bcl xL phospho S62 BD 2 B 1 Defensin B 2 Defensin p 3 Defensin B 4 Defensin B 7 Defensin p 8 Defensin BETA TUBULIN CLASS I C21orf78 6 Calcium Channel gamma 4 CAND2 Cannabinoid Receptor Cannabinoid Receptor Il cardiac Troponin Cdc25C2 CIDE C Claudin 8 CLLD7 COL1A1 C term Corin Ectodomain CPT1A C term CPT1B N term CPT2 C term CROC1A N term CSNK2A1 Ctr CSPS Cul4A CXCL4 DGKB N term DGKG C term DGKI N term DGKQ C term DKKL2 Ctr DNMT3L 1 Dsiglec N term elF2AK3 C term EMSY Encephalitozoon Hellem ENH Estrogen Related Receptor a ETS2 3 FABP4 FACL3 Ctr FACL4 Ctr FACL5 N term FACL6 N term FDFT1 Ctr FDPS N term FGF R5 AB13677 3199 E4441 3201 3239 3249 3527 3531 AB13585 AB3183 AB14778 AB14782 AB3233 XP 5102 AB5299 AB5072 AB13573 AB3883 AB11751 05 849 07 515 CONTROL 12 301 07 644 MAB2084 A300 148A AB9112 183120 MCA2249 XG 6116 AB13862 AB13596 XP 5107BT AB14425 AB14426 AB14422 AB14419 AB14366 AB14365 MCA2047F XG 6118 AB5795 100 401 A12 AB3558 AB3560 AB16412 AB14240 AB16760 40 0700 AB5516 AP6107A MAB2209 AP2524B AP2540A AP2531B AP2164A AP8144C AB16870 100 401 A04 BAF795 AP8127A AP8124B AP8123A AP8122B AP1526A XG
102. SBS A Anti Estrogen Receptor ER SP1 HU MS Rat Hamster IHC p WB M3014 1 ml 95 000 Anti Progesterone Receptor PR SP2 HU IHC p WB M3024 1 mg 95 000 Anti c erbB2 SP3 HU IHC p M3034 1 mg 95 000 Anti Cyclin D1 SP4 HU MS Rat IHC p WB M3044 1 mg 95 000 Anti P53 SP5 HU IHC p WB M3054 1 mg 82 000 Anti Ki 67 SP6 HU Rat IHC p WB M3064 1 mg 82 000 Anti CD3 SP7 HU Baboon Monkey Equine Canine Feline IHC p WB M3074 1 mg 101 000 Anti Alk p80 SP8 HU IHC p M3084 1 mg 101 000 Anti EGFR SP9 HU IHC p WB M3094 1 mg 95 000 Anti Synaptophysin SP11 HU IHC p WB M3114 1 mg 65 000 Anti Chromogranin A SP12 HU IHC D M3124 1 mg 82 000 Anti Calretinin SP13 HU MS Rat IHC D M3134 1 mg 82 000 Anti Placental alkaline phosphatase PLAP SP15 HU MS Rat IHC D M3154 1 ml 82 000 Anti CD8 SP16 HU IHC D M3164 1 mg 95 000 Anti Calcitonin SP17 HU MS Rat Monkey Canine Equine Sheep Porcine IHC D M3174 1 mg 95 000 Anti CD79a SP18 HU Monkey Equine Bovine Porcine Rabbit Guinea Pig Chicken IHC D M3184 1 mg 95 000 Anti CD5 SP19 HU IHC D M3194 1 mg 95 000 Anti Vimentin SP20 HU IHC p M3204 1 mg 79 000 Anti COX2 SP21 HU MS Rat IHC p WB M3214 1 mg 95 000 Anti CD23 SP23 HU IHC D M3234 1 mg 95 000 0e Heady to use 4 1 M3014 M30
103. U 12028 Clostridium botulinum A GAI 92003 Clostridium botulinum E GAI 92012 Candida albicans GTC 1754 Lysis Beads Lysis 260 280 hsm 260 280 1 74 96 8 1 48 51 2 1 89 1 85 117 4 1 46 64 4 1 82 1 84 104 3 1 38 76 5 1 36 1 8 94 3 1 32 48 4 1 95 1 8 97 2 1 45 33 8 2 88 1 76 76 1 1 45 32 6 2 33 1 84 68 4 1 45 20 5 3 34 1 77 91 5 1 5 24 7 3 70 1 78 51 4 1 6 28 3 1 82 SG DNA RNA MORE EXTRACT 89503 CE 27 500 p _ cDNA GeneBeam SEnzo cDNA Ready to use cDNA RNA mRNA A dT 3 dUTP 5 dUTP ENZ RT
104. V MX 8 ere a Fo ES C57BI 6NTacfBr ES Cells TX MES 02 2 vial 498 000 ES Balb c ES Cells TX MES 03 2 vial 698 000 FVB N ES Cells TX MES 04 2 vial 698 000 ES ES ES Swiss Webster Neo Neo Hprt MEF i
105. VIN IS 56 GD3 VIP Receptor 1 AS58 VIP Receptor 2 AS69 Voltage 9ated potassium channel KV3 2 isoform b KCNC2 WAPL WDR9 3 Wnt 8a YWHAB N term YWHAZ C term ZAP70 phospho Y315 Y319 ZMPSTE24 C term ACM ACM RKL RKL CMN ABG ABG ABG RSD RSD CMN ACM ACM ABG RSD ABG ABG ABG ABG ABG ABG ABG ACM BSO BET ACM PSC ABG ABG ABG RSD SPS ABG ABG ABG PSC ACM ABG ACM PSC BET ABG ABG ABG RSD UBI ALO ABG ABG ABG ABG ABG ABG ABG ABG ABG ABG RKL RSD SPS CMN RSD SPS SPS ABG ABG ABG CMN CMN ACM ACM CMN BET PSC RSD ABG ABG ACM ABG Anti AB14261 AB14263 600 101 292 100 401 A14 AB9128 AP8429A AP6263A AP2052A AF2219 BAF2095 MAB8473 AB3440 AB3439 AP6262A AF2220 AP1622A AP1626B AP1632A AP6242A AP6244A AP6245A AP6246A AB15265 44 246G A300 279A AB15267 XW 7587 AP2534B AP2533A AP2183B BAF1797 309 011 AP6249A AP6251A AP6247A XP 5277BT AB16591 AP2601A AB4197 3206 A300 285A AP6810A AP6810B AP6811A MAB17291 07 527 ACC 034 AP2106B AP2107A AP2108B AP2109C AP2100B AP2176A AP2177B AP2178A AP2128B AP8129A 200 401 492 AF1405 149 011 AB5741 MAB2140 131 011C3 135 011 AP1561A AP1562A AP1563C MAB4309 MAB4308 AB16155 AB16156 AB9150 A300 268A XG 6115 AF2248 AP8155A AP8152B AB12869 AP2415B 50 g
106. anog RapmCELL OCT3 4 POU5F1 STATG Nanog ES EG STAT3 Vol 61 No 15 10 2003 2 Mitsui K et al Cell 113 631 642 2003 Nanog PBS 1 Nanog IL a i nii 1 RCAB0003P 200 pk 0 2 mg mk 54 000 Nanog Nanog DAPI PBS pH7 4 OP EtU
107. ence s STKE and Senior Editor of Science American Association for the Advancement of Science T1200 New York Avenue N W Washington DC 20005 USA Sciences STKE 1 Moon STKE Aimee Kohn Moon STKE 004
108. g 0 1 mg 100 Lg 0 1 mg 500 Lk 0 1 mg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 0 1 mg 1mg 200 pk 0 1 mg 0 1 mg 7 mg 0 1 mg 0 1 mg 0 1 mg 100 Lg 0 1 mg 0 1 mg 50 g 0 1 mg 0 1 mg 0 1 mg 0 1 mg 100 Lg 100 Lg 90 000 34 000 34 000 87 000 79 000 34 000 58 000 55 000 55 000 34 000 87 000 34 000 34 000 34 000 34 000 87 000 58 000 71 000 34 000 34 000 34 000 34 000 34 000 34 000 34 000 34 000 34 000 87 000 87 000 34 000 34 000 71 000 34 000 34 000 71 000 71 000 73 000 34 000 78 000 78 000 42 000 87 000 34 000 64 000 34 000 71 000 34 000 34 000 34 000 34 000 34 000 34 000 34 000 34 000 34 000 34 000 34 000 34 000 34 000 34 000 34 000 27 000 54 000 34 000 34 000 71 000 34 000 34 000 34 000 135 000 34 000 34 000 71 000 34 000 34 000 34 000 34 000 87 000 87 000 Neutrimin NICA N term NIP3 BH3 Domain NKp44 NME4 C term NMT1 N term NMT2 N term NP 1 NPK C term NR2E3 NRG1 Ctr NRG4 OAS2 C term OAS3 C term OASIS C term OASL C term Orexin Prepro OSF 2 p28 ING5 p29 ING4 p32 ING2 p47 ING
109. onocytic leukemia Prosci Inc PS6 17 601 5 slide 22 000 17 602 5 slide 22 000 Human Cell 14 Cosmo Bio News No 49 Cosmo Bio News No 49 15 amp 9 ry tT t i la i Anti Anti a Ki 67 1 EGFR HaMAD i LT m M3062 A M3094 ELISA Spring Bioscience
110. rdella S Gurubhagavatula R A Okinoto B W Brannigan P L Harris S M Haserlat J G Supko F G Haluska D N Louis D C Christiani J Settleman D A Haber Activating mutations in the epidermal growth factor receptor underlying responsiveness of nonsmall cell lung cancer to gefitinib N Engl J Med 350 2129 21839 2004 J G Paez P A Janne J C Lee S Tracy H Greulich Ss Gabriel P Herman F J Kaye N Lindeman T J Boggon K Naoki H Sasaki Y Fujil M J Eck W R sellers B E Johnson M Meyerson EGFR mutations in lung cancer Correlation with clinical response to gefitinib therapy Science304 1497 1500 2004 3 R Sordella D W Bell D A Haber J Settleman Gefitinib sensitizing EGFR mutations in lung cancer activate anti apoptotic pathways Science 305 1168 1167 2004 4 L D Walensky A L Kung 1 Escher T J Malia S Barbuto R D Wright G Wagner G L Verdine S J Korsmeyer Activation of apoptosis in vivo by a hydrocarbon stapled BH3 helix Science305 1466 1470 2004 5 S L Sanders M Portoso J Mata J Bahler R C Allshire T Kouzarides Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage Cell119 603 615 2004 6 Y Huyen 0 Zgheib R A DiTullio Jr V G Gorgoulis P Zaccharatos T J Peety E A Sheston H S Mellert E S Stavridi Methylated Iysine 79 of histone H3 targets 53GBP to DNA double strand breaks
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