詳細はこちら - 群馬大学大学院医学系研究科附属薬剤耐性菌実験施設
Contents
1. Probability based Microbial Dissemination Alert P MDA gt alert 2 gt alert 12. PpyA MexAB OprM OprM AOprM OprM AOprM v4
3. 1 1 3 3 4 me 5 ES BO 1 2 3 4 5 6 MRSA MRSA
4. IMP A oA B VIM NDM 1 MBL KPC BB B VE 2 MacFarland No 18 20 FEA Bt 3 KPC 1 NDM 1 2 ATCC H L Invitrogen Health
5. R 4erooas hydrophilaD BAI iM PER HT Chris 5 del Castillo Ho Bin Jang Tae Sung Jung Aquatic Biotechnology Center of WCU Project Gyeongsang National University gt M Aeromonas hydrophila U hydrophila R pR148 pR148 165 906 bp DER DNA 147 pNDM 1_Dol1
6. AUSI OSH4 TIR3 40S7 4S7 C gapra E AUD H Abe Ba A
7. 8 ESBL OM 12 HITS Er 12 12 TA 2 3 EIS ARE 3 3 24 3 4 5 ER n 3 12 6 50 9 ESBL HAR ESBL O7zo aczer freundii 3 Citrobacter amalonaticus 1 Enterobacter aerogenes 1 Enterobacter agglomerans 1 Serratia marce
8. alert matrix
9. Acinetobacter baumannii Bm BR KU ml 17 15 17 20 40 10 17 20 18 10 2 24 10 26 8 00 12 20 12 3 8 00 8 30
10. Ei FFP BB A Alk AR RAR R 4erogoas hydrophila Chris 5 del Castillo Ho Bin Jang 3 aN Tae Sung Jung Aquatic Biotechnology Center of WCU Project Gyeongsang National University
11. E BREA 1 10 PTPC 52 5 MDRP OFRH H B lactamase PIPC B lactamase 1 10
12. 4cinetobacter baumannii MDRAB MDRAB 20 MDRAB1 70 MDRAB strain 1 strain 1 MDRAB strain 2 2 80
13. NBR IMP 1 IMP 1 Ki 0 23 uM 2 K 0 19 uM 3 1 2 uM IMP 1 3 1 4 IMP 1
14. rRNA emm methyltransferase Erm 235 rRNA domain V A2058 Telithromycin TEL Erm A2058 2058 23S rRNA domain A752 TEL 23S rRNA domain 6748 methyltransferase mA TEL TEL G748 Ni mA
15. 8 OprD ampC 018 Pseudomonas aeruginosa PAO1 pTnMod OGm DH5w pRK2013 PAO1 PAO1
16. 0 9 JANIS 2010 1 12 1 JANIS aeruginosa MIC S LR 126 542 25 180 101 862 582 64 319 S LR CLSI 2008 M100 S18
17. 8 SMB 1 1 8 MBL MBL ME1071 HA BUE AR KM BERER FE RI RER 8 30 9 45 HAEDO 2 FD AT MR 5
18. 3 2DCM 2 3 2008 8 2012 7 Ets MRSA 1 000 Antimicrobial Stewardship
19. C glabrata 4 S7 40S7 glabrata eae fu SBR ITU BARE ARDS ATF AVERY ARORA CREF 4US7
20. HA MRSA CA MRSA HA MRSA CA MRSA MRSA 1 G 2 1 3 Cn JANIS 2011 1 309 993 210 382 5 aureus
21. WE RE 3 ESBL 93 91 68 72 13 POR 8
22. Et FRA MRSA POT MRSA ZEN ES EL HAT 2 ON 7 OW set ARE STR Ana Are 11 30 12 15 ar Lv Me TB beads a
23. 7 2008 Extended Spectrum beta Lactamase ESBL 4 pneumoniae imipenem IPM meropenem MEPM Klebsiella pneumoniae ISMRK Imipenem susceptible meropenem resistant pneumoniae T1ISMRK 47 2Kb pKPI6 8 MBL blarmp 6 ESBL IPM MEPM blamp pKPI 6 E coli ISMRE Imipenem susceptible meropenemr resistant E coli IPM ISMRK MBL 26 20 ISMRKCE 1 arMp
24. 4 MRSA Infection Control Network MRSA 2009 4 584 MRSA MIC SCCmec typing PCR Pulsed field gel electrophoresis PFGE Smal DNA MRSA SCCmec type Ik type II type IV V MRSA py7 1 0 tst 62 8 552 MRSA PFGE 299
25. B H 0 5 WU Alexa Fluor 488 goat anti rabbit igG gt HER BOSE ze CBR EEL ARO ALE ImageJ National Institutes of k HEAT E NT E OO RA 1 000 EHRT B NDM 1 B te Bee TER gt IMP VIM B y ES AL BL KA EDEN AN
26. gyz4 E parC 91 DNA gyr4 E parC sequence it i minimal inhibitory concentration MIC 91 7096 ciprofloxacin 4 BH SENS gyrA 5 91 Ser 91 Ile Asp 95 Gly parC Ser 88 Pro 3 ciprofloxacin levofloxacin gatifloxacin MIC ar O i RR CO Y O INTER ETA gyrA Ser 91 Phe Ser 91 Ile Asp 95 Gly parC Ser 88 Pro 4czzeoZzc7er baumanniiD
27. IL 6 TNF a BIPM ME1071 2 12h 12 7 1 5X107CFU ml BIPM 100mg kg 2 12 MBL MBL E In vitro ME1071 MBL EEE 1 ME1071 gt u 11075 MBL 117 Y 7 30h 40 QL 1B Tes BIPM 256ug ml BIPM MB1071 1 0 431ogioCFU ml P lt 0 05 P lt 0 05 AL BIPM
28. 0 84 595 VCM TEIC LZD 5 ABK MIC 16 hg m 2003 FAND 2 201 1 0 2010 3 394 0 76 POT ABK MIC PCR aac 6 aph 2 14 4 256 pg ml 2 595 MRSA ABK
29. 70 K K TB Beads Do TB Beads TB Beads Elution Buffer Elution Buffer PBS SAP NALC NaOH 2012 7 8
30. A er ABK 1 PRIX aac 6 aph 2 TB beads SAP NALC NaOH MEZ SAP NALC NaOH PBS
31. ne 10 00 11 30 3 ESBL ARK BAT Be ELL ARE AU AN EV IH JANIS CLSI aeruginosa co7
32. 4 0 1 mL NTC 63 nM CER 4 72 uM IMP 1 0 1 mL Tris 218 2 8 mL 3 0 mL EL 30 C 10 BE 0 1 mL 3 4 0 10 50 uM CER 0 50 100 200 uM NTC 1 2 3 4 uM CER 5 10 20 40 uM icy Lineweaver Burk 4 1 E 1 4 IMP 1 CER IMP 1 4 50 nM 12 10 i E 8 10 uM H SOE 7 11 0 uM Bat 0 BA 2 1 1 0 2 3 4 5 6 1INTC 10 2 5 1122
33. CCE Taq Man TRC YE LAMP Gene Xpert YE Cephied 4 5 TRC 17 22 12 MGIT 10 1 4 2 2 TRC 3 2 1 TB Beads LAMP TRC 2 100 6 CCE 553 3 9 2 TB Beads 664 6 2 11 1 0 903 83 3 MGIT 100 2 2 CCE TB Beads 10 2 422
34. VRE VanA VanB VanC VanD VanE VanG VanL VanM VanN 9 VRE 2011 10 1 VanN VRE 2011 2 5 90 45 85 102 322 VRE PCR PFGE PCR 322 129 VanC1 349 VanC2 17 5 371 VRE VCM MIC6 12 u g ml 5 faecium
35. matrix 12 alert gt alert matrix JANIS
36. Candida glabrata 14 30 15 00 BEB AE qa gt fit 15 00 16 00 IPM 8 Enterobacteriacea ELBE RAN Sen
37. ICD ICD 0 D 2 41 24 10 25 AR 13 00 18 10 12 55 13 00 HH 12 3 13 00 14 15 B Be ml
38. EU clone 2 baumannii PFGE 37 ATCC 2 39 EU clone Bartual Pasteur Multilocus sequence typing MLST 4 baumannii blaoxa sistike EU clone II baumannii 39 Bartual 21 Pasteur 21 EU clone II CC92 DiaoxA 82 blaoxa 83 gt 18 blaoxa si tke blaoxas ai nt106 108
39. cutoff IMP B KPC ES gt Y Cif au ImageJ Such Acinetobacter baumannii 1 E Acinetobacter baumannii LAT 2 4 European clone II EU clone II de La 2000 2011 1 2 Lh ie y a A
40. een 2007 488 2 DRPM MEPM MEPM DRPM HE MEPM DRPM 2 ra jas E 17 55 2010 9 73 MEPM AUD 2010 FE 1gX8 MEPM DRPM Total AUD 470 2009 468 MEPM 2004 83 2010
41. 24 10 25 268 BEE 41 24 10 25 18 00 24 10 26 4 12 20 509 2207 190 1 TEL 0576 25 2048 FAX 0576 25 2390 http www bosenkan co jp index htm TEL 027 220 7992 FAX 027 220 7996 24 41 1 HE OHH
42. MRSA POT Phage Open reading frame Typing CA HA MRSA POT HA MRSA CA MRSA Na Na USA300 CA POT1 106 CA POT1 93 64 CA MRSA amp HA MRSA 2 co culture 37H24 48 CFU Na 40mM 60mM 80mM 100mM Na 20mM 50mM 100mM 200mM Na CA MRSA USA300 POT1 106 HA MRSA POT1 93 64 24
43. 4 baumannii 4 39 gt Tee i Clonal complex 92 FD Sequence Type 2 ST2 TS blaoxa si like AIR TEIL blaoxa sc EU clone II EU clone II EU clone baumannii EU clone II H SA BE DEB LTR TWA MR 10 4 gt NZ HH E MexB MexY
44. IS RND 1 MexY MexB AcrB FE 2 membrane vacuum cleaner TH 3 Er EN ZA E AcrB f MDRP RND MDRP
45. pYM101 pDS132 5000 HO ZEAE SAFE SER ITV 1 2 at 10000 MIC 4 1 4 copS opz apC MIC 2 MIC ORF PAO1 MIC MIC
46. 2 Bi tu 90 5 PCR 2 ORF 1 01 SS ILA RE O UC A PFGE POT POT2 genomic islet 10 IMP VIM 17 ORF 17 2 10 plex 9 plex genomic islet 10 POT
47. ABC HH im 2011 9 2 2 AcrB MexB References MexY 125 MexY 1 Murakami et al Nature 419 587 593 2002 2 Murakami et al Nature 448 173 179 2006 3 Nakashima et al Nature 480 565 569 2011 4 Nakashima et al Nature under review 2012 PP PP MexY
48. IncA C pR148 Tn27 1IV blaoxajos aadAl sull 1 tetA tetR Tn7Z27 catA2 sull IncU pRA3 pAr 32 aadAl Acinetobacter baumannii AYE 100 pR148 IncA C
49. 3 3 MDRP 3 CAZ PIPC CAZ
50. SBDD CHEST 2002 1 El 2006 CAA 2 a 3 3
51. 18 3 MDRP 6 JVC Polydimethylsiloxane PDMS TORAY 100 C 30min RIE 10NR Samco 6 1 7 SAL 5 ciprofloxacim amikacin AMK imipenem IPM ceftazidime CAZ piperacillin PIPC 37
52. 1 HO 2 alert matrix 2 P MDA Medlasg SHIPL Standardized Hospital Infection Primary Lookout 614 413 259 3 VRE 2 1 47 P MDA P MDA gt alert matrix 2 alert 0 500 0 100 500 1
53. MexT mexEF oprN K Poole MexEF OprN mexT mexS z 7xC QS PAO1 2 nfxC QS nfxC MexS QS QS MexAB OprM MexS MexE
54. B lactamase O B MBL 4 AN E KPC E
55. VanN 2 VanN VRE VanN VRE Candida glabrata PERIS Candida glabrata
56. sam 1 GyrA Ser83Leu ParC Ser80Leu MLST Bartual ST135 stram 1 strain 2 clonal complex 92 ST 92 ST 189 Institut Pasteur STI strain 1 2 ST2 Bartual CC92 XU Institut Pasteur ST European clone Institut Pasteur ST1 European clone I MDRAB MDRAB CTX M fosfomycin fos4 ps PERE
57. TEL 7A rRNA 1 gt Am ME VRE MIC vanB Enterococcus faecium gt VRE 3 Enterococcus faecium
58. PvdS PAM01 PAM02 PAM01 PAM02 AOprM PAM02 AZT CP 0 5 pg ml 4 pg ml AOprM PAMO1
59. PRGBS2 PSGBS1 9 nn 4 CTB PSGBS PRGBS PBP2X 2B 1A MLST 7 adhP pheS atr gInA sdhA glcK tht Ete Smal DNA CCL MIC PSGBS 1 2 ug m1 CTBTPSGBS PRGBS 8 16 ug m1 CZX MIC PSGBS 0 064 0 19 ug ml PRGBS gt 32 ug ml CTB PSGBS 0 75 1 5 ug ml CTB PSGBS PCG ABPC CTB PSGBS6e PBP 2X T394A PBP 2B TS67I PBP 2X G429S 3 PBP 1A T145A 3 PRGBS2 PBP 2 2 400 V405A 0557 PBP 2B TS67I PBP 2B CTB PSGBS PFGE CTB PSGBS
60. 3 B Fosfomycin FOM 40 FOM FOM os43 76sC2 6s43
61. 3 E OBIE 07 7 EN amp LILA Y
62. CLSI Clinical and Laboratory Standards Institute 2008 actam BP 2010 M100 820 CEZ CTX CTRX CAZ BP 8g gmL 1z gmL 2012 M100 S822 aeruginosa PIPC BP 64 16g g mL IPM MEPM BP 42 52 u g mL BP aeruginosa Wik JANTS 2009 2011 6 8 BP BP SE coli aeruginosa E coli OCEZ CTX CTRX CAZ BP BP 1 lt 8 aeruginosa BP BP PIPC 87 76 IPM 78 60 MEPM 79 64 11 15 3
63. Serratia marcescens B MBL SMB 1 X E coli BL21 DE3 pLysS pET30a X Photon Factory SMB 1 1 6 A SMB 1 MBL B3MBL SMB 1 B3MBL AIM 1 L1 BJP 1 722 N 2 1 2 SMB 1 N
64. lt MAX MIN 14 7 JANIS AMK 2 3 1 18 4
65. 49 ST CC POT1 ST CC 1 1 26 ST 33 POT POT1 POT2 23 POT1 12 POT1 2 3 HE 108 genomic islet genomic islet POT gt alert matrix BH I 1 2 3 4
66. MIC 5 mexS mexT OBER HAMAS ORI KU nfxC ex7 MexBEF OprN Quorum sensing QS MexAB OprM B lactam
67. A 1 15 B Y 157 SMB 1 AIM 1 B8MBL 157 MIC MIC 157 SMB 1 Er MBL MBL SMB 1 7372B8 3773 7
68. a 378 217 2011 161 2 IMP type B AAC 6 Iae AAC 6 Ib 4 MIC B 2009 2010 217 IMP 174 80 2 AAC 6 Iae 145 66 8 AAC 6 Ib 21 9 7 2011 161 1MP 101 62 8 VIM 1 6 80 49 6 AAC 6 Ib 35 21 7 2010 2011 IMP 6 AAC 6 Ib AAC 6 Ib 66 PFGE 60
69. 1 5 BIPM ME1071 ff ME1071 MBL P lt 0 05 1 8ug ml f f BIPM Hi 30h 4 40 0 22 HAE PERE Y mee FICE RIES Y E y ES 115 MBL 4 5 27 0 34 6 25 HER DREH 0 3518 9 4 317 4 BIPM D T gt MIC 10 3 ME1071 BIPM 0 VAP REO ISA BS 5 ART 1A
70. BP aeruginosa PIPC 11 15 BP BP HE P aeruginosa y SER w tt 5
71. E B2 2 5 Al 5 E 2 E D 6 6 A D an FQ itt Susceptible III IV I Ia Ib Ic 10 FQ FQ CEP 1a 01 8057648 D 01 ST648 D kspM ompT PAI ORF BMA BIC D PFGE 5 FQ CEP FQ 6 FQ ST648 D O1 ST648 FQ E
72. 7 PFGE ESBL 74 64 54 36 50 3 6 20 8 HTC DU blaman s 6 11 5 CNS blayy 22 6 PFGE 2 8096 Ment Elo 22 FIB 120kbp
73. OR C 1 91 MEHR pa7C Acinetobacter baumannii AZ Ba
74. JR 20 JR 2 12 30 12 45 gt Ne 10 23 12 00 1F 14 00 17 000 1 000 6 000 10 000 FJ HERR 12 3 CT 1 12 USB PC windows7 PowerPoint2010 Macintosh PC COI
75. 2009 8 ES ES 1 TDM 2 MRSA patient day MRSA H 94 2 522 554 5 2 3 E RQ0 0001 3 11 6 19 UE _ 2 3 0 001 ae a MRSA
76. CTX M fosfomycin fos4 AL 16 00 16 30 a HA 1 A ix lel O DIESE TT AER ARA E LEA Y 2 PROSE WoT A pt er UO BUG Aa ee aes FR 16 45 17 15 B lactamase
77. BE 9 gt alert matrix AE HE 12 15 12 20 AZORES A270 gt RRS Al er gt Ah Re Be oe RAP
78. 16 1 114 933 MRSA aureus 54 6 MRSA MRSA JANIS aureus 394 2003 S aureus 201 595 MIC MRSA VCM TEIC LZD ABK ABK MIC Phage open reading frame typing ABK aac 6 aphQ2
79. 3 faecium 2007 2011 4 A 25 VRE VRE 1 at Cla VRE 1 AB VRE FEAR ES 4 VRE VRE VRE H MIC 4ug ml
80. 4 PCR based ORF typing Fon ORF POT1 POT 415 multilocus sequence typing MLST PFGE 7 BERUFE POT 107 410 8 20 646 8 24 PFGE 410 8 79 646 8 94 024 82 D ST 59 singleton ST MLST clonal complex CC y ST 141 POT MLST 94 POT eBURST 6 clonal complex CC
81. MDRAB blaoxa blaapc 16S tRNA PCR DNA GyrA IV ParC MLST Bartual Institut Pasteur B 4 gentamicin amikacin arbekacin strain 2 2 3 ISA bal blaoxaoz ISAbal 5 IRL DiaoxA23 strain 1 MDRAB 34 bp strain 2 7 bp 27 bp aoxa cs sam 1 12 154 1 strain 2 oxA ISAbal blaoxas OXA 82 OXA 66 1
82. oprM PAM01 0 5 mM AZTD CP MIO OprM OprM AOprM AZT 0 25 ng7m CP 2 pg mD MIC AZT 4 ug ml CP 32 pg ml PAM01 AZT BLU CP MIC IE 0 25 pg ml 4 pg ml 2 ug ml 16 pg ml v4 oprM OprM OprM OpM
83. CTX M FOM CTX M Escherichia Do CTX M coli FOM FOM fos4 2010 1 8 CTX M coli 145 FOM MIC FOM i CLSI M7 A8 fos43 fosC2 Wachino Wachino J et al 2010 J Antimicrob Chemother EK L primer set PCR ESBL TD Shibata N et al 2006 Antimicrob Agents Chemother Inc type Carattoli A et al 2005 J Microbiol Methods
84. MRSA he MRSA ee ER y GD 7 E O RYE OED MRSA 0 ee 36 JANIS CLSI aeruginosa coli OYE ab
85. CTX M coli 145 FOM E MIC 128ug mls 9 6 2 3 6 7 192 4 8 8 16 Lee SY et al 2012 J Antimicrob Chemother 3 s43 6sC2 Inc type Inc N type 1 IncF type 2 IncI1 type 2 blacrim CTX M FOM 1 2 MERO FEV
86. yog7 Bik 8ug ml Enterococcus VRE VRE VRE 3 f 25 8 17 VRE 13 E BYERS ore Cad 18 EU OD 2 VanN VRE 1 AR WER Ei H of
87. PRGBS CTB PSGBSe PRGBS MLST ST1 EUCAST PCG B CTB CCL GBS CTB PSGBS PCG GBS PBP B MIC PBP B 2 rRNA
88. 2 CHR ESTES Dd AN RI php ORB O he eA oe LCD ST 57459 PROBS SE Lb RE E EE STIPSGBS 4 57 PROBS Heo ah LL TASA PEGAS 12 9708 rote 57 87458 PRGBS 7 serotypeV 1 PSGBS 07 serotypeV Abi gt AE A SET PROBS gt PSOBS ST EHRE bE TS Ait AE PEGAS ST tee B 2 2 CTB B GBS B PRGBS PSGBS CTB GBS CTB PSGBS 2011 5 2012 1 nn CTB PSGBS6 Tb
89. 4 MRSA MRSA MRSA POT MRSA o MRSA Methicillin resistant Staphylococcus aureus CA HA
90. LAMP TB Beads 1 4 1 2 4 5 Graed P2 P1 P3 P1 BK 2 1 1 MGIT MGIT TB M avium TB TB Taq CCE 31 3 44 3 37 1 Man Beads 37 8 41 8 47 0 ae CCE 536 465 1022 Beads 817 512 1731 ME CCE 8 42 11 42 12 48 Beads Xpert CCE 13 7 18 4 25 5 Beads 18 6 21 2 23 7 BRA Taq Man Ct TRC sec LAMP min Gene Xpert Ct 2 TRC Beads 16 0 16 CCE 0 6 6 16 6 22 E 3 1 n 12 3 2 n 10 Beads Beads tm ok 5 5 2 0 7 10 0 0 10 CCE CCE 0 4 0 4 0 0 0 0 0 1 1 0 0 0 0 5 6 1 12 E 10 0 0 10 OPA ESA Y AED AE 0029
91. 5 50 HOW 30 60 0 IMP 7 B NCGM1588 aminoglycoside acetyltransferase AAC 6 laj aac 6 Iaj 2 IT aac 6 7a7 integron DNA AAC 6 Iaj AAC 6 Ia aa 70 6 MIC AAC 6 Tae IPM 8 Enterobacteriacea 2 9 HEAT AUR KEE RRR OUR
92. 50 0 CEP 2545 51172 0 98 E 10 EE FQ CEP fit CEP IA HR E PERE 92 FQ CEP BE LIER E S FQ PFGE MLST D FQ 59 1 D H r 0 58 B2 8 9 D 5 3 B1 3 9 A 3 3 A 5 8 B1 5 3 Al 4 D 2 mp v 4 1 IV 1 1 IT CEP mt FQ CEP
93. 94 MEPM AUD E 0 859 p lt 0 005 MEPM DRPM 0 074 p 0 849 H MEPM DRPM ls DRPM ES gt LIED OB HER 5 OAR IMP type B aminoglycoside acetyltransferase AAC 6 Iae 2009 2011
94. CFU Na 24 CA MRSA CFU HA MRSA 100mM CFU Na 200mM 48 CA MRSA CFU HA MRSA CFU Na 48 CA MRSA USA300 80mM CFU 0100mM 4 POT1 106 60mM CFU 80mM CFU HA MRSA 40mM CFU 60mM CFU HA MRSA CA MRSA CA MRSA Na 2 CA MRSA HA MRSA
95. DVASAL RPA WIEBE AI 4 Abe Cid one 8 2003 AUD 2003 2010 4 2004 480 ES O MEPM KH Total AUD MEPM Total AUD 0 MEPM E EE l 2011 9 E AUD 2003 4 2011 13 12 2011 AUD
96. B HA MIC ra Enterococcus faecium 2 VanN VRE EA
97. pneumoniae 5 IMP MBL arwp s4 80kbp LIMP 34 IMP 1 1 87 Glu Gly 1PM blamp s p7arup 1 blamap e blarmP 34 91 gyrA parC O AENA O RARO MRE REL TRAS gyr4 E parC
98. PFGE D Ala peptide ligase PCR PCR ligase Inverse PCR VanN 1 1 1 S1 Nuclease PFGE ligase on VanN EY VRE E faecium D Ala D Ser ligase VOM VRE E faecium VanN VanN
99. MBL BERBELIZAIERHBENX 2 2 12 1 1 2 2 2 2 ME1071 MBL MBL ddY SPF 5mm VAP lt lt VAP 277 B MBL 6 3Fr 2 MBL MER1071 8 BIPM 100mg kg 1071 100mg kg 1
100. OP AS a BAT Daher WRENN ur Haru ORT Gt aE ATS ES GOR SSS RE ose DAR PROS TAL ST MANE sequence typing MLST MEO PoE CSE PROS Meet 50 SORA oa mn E STE grep MELT ed Se A Be PEGATINA E 6 0 af RES PROBSES Ps AAA ST group lt Line TE ine ll MODS Eh eae Tee he 5 PRGBS 5 PRR rien emerpaitlo GES PEGAS ST TOMS SR RSA oI CALA ott HE gt ST OSE PROBS LET Ss ET PROBS oe EMS Ariel 2001 es HA TRA ERA A PECES CAG ie 0 E MLST Week Ae AA EH he str ln ele okt allele SEMEL allele profile DMA it ST RELA ME a Kate a z POST it FOLIEN ST 10 153 12 57 23 44 11 1 2 lt 11 3 2 9 65 SH RSSE ST ah LE STII A Awe TR 92 ST Yee PROBS L aT Bese 6 DE PAGES Ti Stila EM at ST os RL PROBS STI groul 5 probilo SH TOA TRA GRE Laer salt ES BT SAS EL Ga Be STI Fiir PAGES Tite TRE SLA STAM PSONS THAR bot PROBE yh ASTM STADE ST
101. 00 uM 2 100 uM 1 im 1 50 uM 0 0 nM 2 0 2 4 6 8 10 1 ACER 10 MT Fig 1 Plots of 1 v E against 1 S for hydrolysis of NTC A and CER B by IMP 1 in the presence of 4 mercaptobutyric acid Kk 44 uM 37 uM 3 4 2 3 Y IMP 1 8 8 1 RES N 1 IN 2 Vak 3 Bi
102. 7 EN HB P aeruginosa ER
103. F OprN MexS 2 mexS MexEF OprN MIC PAO1 mexS MexS MexEF OprN MexT MexEF OprN MexS MexEF OprN 2 1 FQ 3 1 F
104. Q CEP CEP FQ ZE a FQ CEP 2 E pal E FQ a OD 37 1 E heey eT D417 AV TY 14 Susceptible 35 0O Susceptible group B1 34 3 B2 40 0 40 0 FQ CEP FQ FQ CEP FQ CEP
105. scens 1 Klebsiella pneumoniae 1 Escherichia coli 1 ESBL CTX M 1 group ESBL 3 14 8 vs 8 7 23 5 vs 6 1 CTX M 1 group ESBL FRAME MZ 4 FE 1 4 gt XE 4 Pos XZ
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