別紙3（PDF：910KB）
Contents
1. 17 7 CYP2D6 CYP2D6 I 10 12. P450 2D6 P450 2D6 CYP2D6 P450 2D6 3 poor metabolizer intermediate metabolizer extensive metabolizer 3 boor metabolizer
3. ID 10 ID oh 3 xTAG CYP2D6 CYP2D6 ID kit v3 RUO CYP2D6
4. 15 6 CYP2D6 6 1 xTAG CYP2D6 kit v3 RUO CYP2D6 2 xTAG CYP2D6 kit v3 RUO CYP2D6
5. ID 10 da ID
6. 6 CYP2D6 9 330 000 1 150
7. ami 541 061 35 038 15 607 591 706 xTAG CYP2D6 v3 RUO CYP2D6 EDTA Na 2mL 4 xTAG CYP2D6
8. 1 1 18 2
9. 14 se 5 CYP2D6 7 2 2 1 Extensive metabolizer 68 2 Intermediate metabolizer EE 33 a 0
10. 2 1 CYP2D6 QOL 1 xTAG CYP2D6 kit v3 RUO CYP2D6 2 xTAG CYP2D6 kit v3 RUO CYP2D6
11. 12 3 CYP2D6 5 E 10 2 13 4 CYP2D6 7 1 xTAG CYP2D6 kit v3 RUO CYP2D6 CYP2D6 99 CYP2D6 100mg
12. C oO m gt A poor metabolizer 3 he A 1 1 ez CYP2D6 A A C
13. y 1 2 4 CYP2D6 27 7 17 8 3
14. pharmacogenomics 1 541 061 A 1 2 CYP2D6 I 1
15. 100mg CYP2D6 Intermediate metabolizer IM Extensive metabolizer EM 20 2 CYP2D6 xTAG CYP2D6 kit v3 RUO 2 1 Extensive metabolizer EM 1 Intermediate metabolizer IM EM IM
16. 1 I RO 2 1 2 1 200 10 1 Ek 24
17. CYP2D6 xTAG CYP2D6 kit v3 RUO kit Luminex 100 7200 kit xTAG PCR PCR ASPE ASPE 5 xTAG ASPE 5 xTAG Luminex 1007200
18. poor metabolizer intermediate metabolizer intermediate metabolizer CYP2DS 2015 3 P450 2D6 CYP2D6 CYP2D6 ultra rapid metabolizer URM extensive metabolizer EM inte
19. A C A pm 5 og a Ce C RN B A ae BB C A B C
20. SAP EXO SAP EXO PCR ASPE Allele Specific Primer Extension ASPRE Streptavidin R Phycoerythrin SA PE Luminex 1007200 4 xTAG CYP2D6 kit v3 RUO CYP2D6 Intermediate metabolizer IM Extensive metabolizer EM 1 100mg 1 2 Ultra Rapid Metabolizer URM Poor Metabolizer PM 5 CYP2D6
21. xTAG CYP2D6 kit v3 RUO DNA PCR DNA 2 dNTP Shrim Pa 24 ng 1800 ng PCR PCR PCR B PCR SAP p Alkaline Phosphatase SAP EX0 ul EDTA DNA F PCR A PCRB 2 PCR SAP EXO PCR ASPE Allele Specific Primer Extension ASPE Streptavidin R Phycoerythrin SA PE Luminex 100 200 4 xTAG C
22. 100mg CYP2D6 Intermediate metabolizer IM Extensive metabolizer EM 20 2 CYP2D6 xTAG CYP2D6 kit v3 RUO 2 1 Extensive metabolizer EM 1 Intermediate metabolizer IM EM IM
23. 1 1 5 II 2 1 2 24
24. a V3 RUO ASPE wm EM IM 1 2 100mg PM 1 1 100mg URM Vy a Luminex Analyzer LUMINEX TDAS CYP2D6 2 ID 2015 9 2016 8 2017 8 100mg i i mm a mm mm mm i mm om i em mm mm mm om mm mm mm om mm mm om Em OE CYP2De 100mg xTAG CYP2D6 2015 9 2017 8 ii je
25. A 1 1 ez CYP2D6 A A C A C A og Ce C RN A B
26. A CYP2D6 EN IM
27. ID 3 xTAG CYP2D6 kit v3 RUO CYP2D6 CYP2D6 xTAG CYP2D6 kit v3 RUO EDTA DNA DNA 24 ng 1800 ng 7 PCR DNA PCR A PCR B 2 PCR 2 PCR PCR PCR B dNTP PCR SAP Shrimp Alkaline Phosphatase
28. a i a a i i i i ji i a a a a a a a a a a a a a a 10 1 CYP2D6 1 2 3 11 2 CYP2D6 3 330 000 1 150
29. YP2D6 kit v3 RUO CYP2D6 6 E f 16 Intermediate metabolizer IM Extensive metabolizer EM 1 100ng 1 2 Ultra Rapid Metabolizer URM Poor Metabolizer PM 5 CYP2D6 6 CYP2D6
30. rmediate metabolizer IM Poor metabolizer PM 4 CYP2D6 CYP2D6 3 xTAG CYP2D6 kit v3 RUO xTAG CYP2D6 xTAG CYP2D6 20 2 5 CYP2D6
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