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重症心不全に対する植込型補助人工心臓治療
Contents
1. MJR EBB H BRAK Ea Jt Hid Jt E mAs CE A E E E E S JE HS 3 JB JB mE
2. DIAL II Ia IIb DIAL LAW A
3. HOWL ES om Wut SEHE D
4. OBIT fe WE c 8 TE Bis JOE E EEIZBIS SOA 2013 BTD BIT BTR DT DT lt 3 5 2 LVAD LVAD
5. 3 3 3 3 1 NA 4E 1
6. pui TE Bie OBM E ACET SOT 2013 3 3 6 LVAD
7. LVAD F de air LVAD LVAD LVAD LVAD TEE
8. JE 5 8 I 68 Edir 7 gt JRA 1 4 3 lt 5 AA 3 1 2 TE BE DET E EISE SOL 2073 2011 2012 a
9. TAP VAD 3 1 4 VAD VAD VAD VAD LVAD 197 254 Heyde angiodysplasia 2 von Willebrand vWF jk 4p 250 shear stress vWF
10. inflow cuff 3 5 3 5 1 LVAD LVAD BTT BTR LVAD DT LT BTD LVAD BTT BTR BTD DT LVAD
11. B i 100 4 5 6 f FESS 8 5 3 1 90
12. 9 590 Ca e 2 4 2 __ TEE LVAD de air TEE 151 152 a PFO LVAD
13. ZH E 99 FFP CODES IDE TX Wal EXSY K BA 2 5 4 VAD
14. gi Fontan LVAD 2005 LVAD 779 OB Clark 89 Glenn LVAD Fontan Glenn LVAD
15. CRP C X AVE 217 VAD VAD
16. Profile 1 SOWA LVAD v VAD LVAD PCPS Profile 1 VAD LVAD VAD 2 3 LVAD
17. RVAD 2520 2 5 15 J MACS VAD 6 144 LVAD BE 39220 n 20
18. WER aI OPE E ARBRIT SAT 2013 2011 2012 AE b RVAD 199
19. 5 20uglkg min 0 05 0 5 uglkg min PDE III NO 20 40 ppm 2 15 U hr 8 d LVAD 9 FFP
20. S90 VAD VAD 65 3 80 2 99 VAD
21. IABP VAD 24 2012 4 LVAD JOTN K604 2 19 LVAD LVAD 1 D 2005 Novacor K604 2 2 LVAD
22. T EVAHEART DuraHeart ILS intermittent low speed Jarvik 2000 HAH LVAD
23. 2011 3 79 2012 10 Richardson P McKenna W Bristow M et al Report of the 1995 World Health Organization International Society and Federation of Cardiology Task Force on the Definition and Classification of cardiomyopathies Circulation 1996 93 841 842 Silver MM Silver MD Cardiomyopathies In Silver MD editor Cardiovascular Pathology 2nd ed Churchill Livingstone 1991 743 809 Miura K Nakagawa H Morikawa Y et al Epidemiology of idiopathic cardiomyopathy in Japan results from a nationwide survey Heart 2002 87 126 130 Miura K Matsumori A Nasermoaddeli A et al Prognosis and prognostic factors in patients with idiopathic dilated cardiomyopathy in Japan Circ J 2008 72 343 348 Abraham WT Fisher WG Smith AL et al Cardiac resynchronization in chronic heart failure N Engl J Med 2002 346 1845 1853 Moss AJ Hall WJ Cannom DS et al Cardiac resynchronization therapy for the prevention of heart failure events N Engl J Med 2009 361 1329 1338 Cleland JG Daubert JC Erdmann E et al Longer term effects of cardiac resynchronization therapy on mortality in heart failure the CArdiac REsynchronization Heart Failure CARE HF trial exte
24. 109 LVAD g LVAD
25. WES 11922279 WER ae IG OREM E ARBRIT SAL 2013 2011 2012 116 3 2 21 _ LVAD
26. LVAD LVAD LVAD WER ae IG OREM E ARBRIT SAT 2013 gt 2011 2012
27. 10 35 55 30 50 102 2 1 10 VAD VAD QOL UE
28. HAH LVAD X CTR CT TEE 259 VAD VAD VAD ACE ARB Ca
29. EVAHEART 1500rpm APTT 1 5 2 0 PT INR 2 5 3 5 WERE OBZ EVERITT 2013 2 3 2 DuraHeart DuraHeart LVAD Wit S M L 3
30. 3 3 7 a QOL 3P X 2 b 79 30 40
31. VAD bridge to decision VAD C LVAD llb B 1 CRT LVAD BIT 72A VAIL B 2 Na ME SWE BRE lla B 3 CRT
32. VAD LL TEER ASE c VAD 2 5 7 _ WER ae OREM E ARBRIT SAL 2013 2011 2012 VAD
33. E VAD 2 VAD GRAVE X BF X PDE M NO RVAD
34. 6 8 20 FICHE BIDS L 194248 pump endocarditis LVAD 2 2 9 30 3 1 3 1 22 LVAD 59 d
35. COD BEE aa mz A ER E TIVE CSL WB MSD WB ORA WE ARLE ADE zo 2 se FIVE CSL
36. CT FFP LVAD 0
37. 1 3 1 8METs 3 30 io 32 c
38. St LE WER ae OREM E ARBRIT SOT FAL 2013 2011 2012 HeartMate II BTT 281 8 THE 4 139 c d SHREE MS MS e MR MR VAD MR HeartMate II BTT
39. V LVAD LVAD LVAD J MACS brdge to transplantation possible bridge to transplantation possible bridge to transplantation destination therapy ADHF bridge to recovery ADHF OBEREZ7 l KERET rescuetherapy 1 1 2 bridge to transplantation BTT LVAD
40. Vo PCPS LVAD PCPS e fet LC LVAD VAD
41. VAD 19 9 Hee Pe CT VAD 192 194 2 5 3 VAD
42. 2 29 265 255 256 II AR
43. 1 1 2 3 4 3 TE Bt os AO REBE E SELBE AUNT 2013 2011 2012 65
44. ST TEE Trendelenburg 199 2 4 3 a
45. VAD 10 BERL 8 EE TE peripartum cardiomyopathy VAD BTR BTR 39 VAD LVAD 1 2 VAD 124 VAD
46. PDE IABP 65 65 stage D NYHA 75 AN OBHE QOL QOL COPD 30 2
47. CRT 449 4850 c VAD BE 3 10 7A 17 3 A EXKI 4 1 5 4j E 86 9 Fabry p
48. 2010 http wwwj circ or jp guideline pdf7 JCS2010_matsuzaki_hpdf 2012 10 Tang AS Wells GA Talajic M et al Cardiac resynchronization therapy for mild to moderate heart failure N Engl J Med 2010 363 2385 2395 Yoshioka D Sakaguchi T Saito S et al Initial experience of conversion of Toyobo paracorporeal left ventricular assist device to DuraHeart left ventricular assist device Circ J 2012 76 372 376 Worku B Pak SW van Patten D et al The CentriMag ventricular assist device in acute heart failure refractory to medical management J Heart Lung Transplant 2012 31 611 617 Samuels LE Thomas MP Holmes EC et al Insufficiency of the native aortic valve and left ventricular assist system inflow valve after support with an implantable left ventricular assist system signs symptoms and concerns J Thorac Cardiovasc Surg 2001 122 380 381 Hatano M Kinugawa K Shiga T et al Less frequent opening of the aortic valve and a continuous flow pump are risk factors for postoperative onset of aortic insufficiency in patients with a left ventricular assist device Circ J 2011 75 1147 1155 Goda A Takayama H Pak SW et al Aortic valve procedures at the time of ventricular assist device placement Ann Thorac Surg 2011 91 750 754 Feldman CM Silver MA Sobieski MA et al Man
49. Na 109 2 1 4 AST ALT LVAD 2 LVAD LVAD 2 0 5 0 mg dL LVAD LVAD 2 1 5 Na
50. III VAD VAD PREA AMPLAZER266267 78 3 1 6 _ VAD ICD VAD
51. 19 O Bka Swan Ganz 10048 VAD 2 4 4 RVAD
52. 185 180 IABP 7 281 HeartMate II 30 26 9 3 Va A 188 g HK HAMIL LTH 9 VAD
53. 53 59 E Th Th LT gt IH TE Bi ODER E ACET SOA 2013 d 39 VAD 5 8 EF VAD e
54. 235 236 237 238 239 240 24 par 242 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 Kartha V Gomez W Wu B et al Laparoscopic cholecystectomy in a patient with an implantable left ventricular assist device Br J Anaesth 2008 100 652 655 De Silva A Smith T Stroud M Attitudes to NICE guidance on refeeding syndrome BMJ 2008 337 a680 Mehanna HM Moledina J Travis J Refeeding syndrome what it is and how to prevent and treat it BMJ 2008 336 1495 1498 2012 325 335 Teuteberg J Lockard K Chapter 14 Predischarge and outpatient management In Kormos RL Miller LW editors Mechanical circulatory support a companion to Braunwald s heart disease Elsevier Saunders 2012 183 193 Moazami N Smedira NG McCarthy PM et al Safety and efficacy of intraarterial thrombolysis for perioperative stroke after cardiac operation Ann Thorac Surg 2001 72 1933 1937 discussion 1937 1939 Masotti L Di Napoli M Godoy DA et al The practical management of intracerebral hemorrhage associated with oral anticoagulant therapy Int J Stroke 2011
55. LS Profile 3 INTERMACS Profile 4 VAD Profile 4 6 Status 2 LVAD INTERMACS modifierA 1 2 ICD VAD 85 82 1 2 b 2013 65 io LVAD 65 LVAD 2 3 166 167 5 BMI
56. 2 3 1 EVAHEART EVAHEART LVAD D 118 800 rpm 1500 rpm
57. 2011 2012 LVEE30 LVEDD 65 mm RY TIE Fic LVEF PCWP 3 LVAD LVAD HeartMatell destination therapy trial 1108 LVAD 1 8 3 LVAD t LVAD reverse remodeling LVAD 3 LVAD LVAD AR 3 AR reverse remodeling 3 ORRO inflow cuff
58. VAD VAD 1 2 2 _ a 488 Sc 79 b LVAD 2006 NHLBI 5 3 LVAD PediPump7 infant Jarvik PediaFlow VAD LVAD 7 LVAD 79
59. WER ae OBI E EBIB AT 2013 VAD VAD E 3 2 3 VAD LVAD 90
60. BTT LVAD E34 LGA LT 2005 2006 2010 LVAD m TE Bi JOE E ACTER 2013 Il Sin EU NE NG MN ERE DRE ES 158 1 RR RR NR Aad qi iQ V Rcs 1 58 2 163 p IB 00o 174 et ERU esa bbe bua aioe SR RR UHR 181 rm 183 NS E A a A A A E 184 2010 11 16 2
61. S 14mm 119 VAD BTB VAD ROO VAD CE 14 mm 87 24 72 APTT 0 70 PT INR H2 5 3 0 3
62. 5 m EBD SE ACT 3 2013
63. 69 TE Bi JOE E ACTER FFI 2013 RVAD LVAD 2 8 6 3 127 133 171 172 RVAD Profile1 1 Profile2 93 Profile 3 7 RVAD 3 RVAD 79 7 Jarvik LVAD Jarvik RVAD HeartWare LVAD HeartWare RVAD DuraHeart LVAD Jarvik RVAD VAD 2 5 l ICU E
64. EBM FEA LVAD EVAHEART DuraHeart HeartMate II Jarvik 2000 4 36 LVAD LVAD LVAD Bot
65. 9 b 4 E A PERLE ZS CREE ULE Fabry ii ADNAN 4m AO 10 14 0 A 3 6 99 5 6 3 75 7 3 VAD
66. 8000 12000 rpm 64 8 intermittent low speed 13129 29 APTT f 40 45 L PT INR 2 0 3 0 2 2 3 5 HeartWare Ventricular Assist Device HVAD 128 29 R
67. 9 9198 99 100 100 LVAD LVAD 2
68. REPR E 2 4 l VAD 2 4 1 a A TE Bip JOE E ACTER FIY 2073 39 2 8 BIS bispectral index 4 4 b
69. 289 32 7 8 3P 3P H
70. J MACS 1 Tr kinking 15648118 A 2 5 2 ME LVAD
71. 150 MS LVAD 7 5 mm 9 TEE 9 LVAD TEE LVAD I LVAD 2
72. 186 204 210 1 2 21 RVAD 215 217 2 5 14 J MACS 14 GOT AST GPT ALT 2 3 LVAD 25 219 amp lt
73. 2 3 4 Jarvik 2000 Jarvik 2000 2 5 cm 90 g 1 2 m 2 3 24 20 mm
74. iia v TE Bie JOE E ACET SOT FIY 2013 OEY BTT 1 1 3 bridge to candidacy BTC LVAD LVAD 22 L
75. 20 VAD VAD FILE STIEN p 052 LVAD 233 239 2 5 19
76. C AR AR LVAD LVAD AR 9 AR LVAD 91 9 ZRF TR MR TR 9 TR MR LVAD
77. 3 D WER ae IG OREM E ARBRIT SAL FAL 2013 2011 2012 refeeding 236 238 VAD re 3
78. VAD IMACS Japanese registry for Mechanically Assisted Circulatory Support J MACS zi TE Bi ORE E ARIAT SOA BAT 2013 LVAD 2 2 3 2010 1 1
79. 242 PT INR 239 TE Bis JOE E ACET 3T 2013 312 a 9 EK PIA 724 VAC CECH B
80. 191 192 VAD LVAD VAD if 7 CNH ATC 9 2 5 18 VAD 22227 28229 LVAD
81. 7 b D El volume of distribution 99 SET 2 O 4 9 BIS HA 195 c PDE II
82. B C 1 WER aI OREM E ARBRIT SAT FAL 2013 2011 2012 1 acute decompensated heart failure actvities of daily livings aortic insufficiency alanine aminotransferase activated partial thromboplastin time aortic regurgitation angiotensin Il receptor blocker aortic stenosis American Society for Artificial Internal Organs arteriosclerosis obliterans aspartate aminotransferase bispectral index body mass index brain natriuretic peptide bridge to bridge bridge to candidacy bridge to decision bridge to recovery bridge to transplantation biventricular assist device Centers for Disease Control and Prevention cardiac index chronic obstructive pulmonary disease C reactive protein cardiac resynchronization ther
83. 2014 4 33 89 2014 2 3 LVAD J MACS INTERMACS 2 3 1 INTERMACS LVAD BRL National Institute o
84. J MACS 3 J MACS 12 2010 6 11 114 J MACS 24 VAD VAD VAD VAD 749 VAD
85. 219 ASTM F1841 97 ISO 10993 4 ISO 14971 VAD 1998 ASAIO STS 5 2009 NationalClinicalTrial Initiative Reliability Subcommittee 19 VAD 7 80 confidence level 60 reliability
86. lla B T LVAD l Jv C 8 LVAD I C LVAD Ilb C 9 LVAD l C 10 BMI 30 40kg m2 VAD LVAD Ib B 11 LVAD 7 2A C 12 VAD VAD LL C
87. NYHA TIII EMPHASIS HF NYHA 7 TII 9 HA LVAD 2010 89 WERE OBM E VERICIT AT 2013 LAER amp HAA HESSE 72 C do CRT D CRT D QRS 120 msec 35 NYHA HI RAFT NYHA II QRS 150 msec CRT D LVAD
88. WER arm OREM E ARBRIT SAT FAL 2013 2011 2012 2 1 3 LVAD 2 0 mg dL HAH LVAD eGFR hANP V Na 09 NIP UY VEE CHA h
89. 4 1 2009 2011 EVAHEART DuraHeart 7 2 LVAD 2014 44 33 2011 AM LVAD LVAD LVAD 2014 1 300 in 2 WAW LVAD LVAD
90. d 2 e 9 m 3 4 3 4 1 LVAD LVAD A
91. 2 5 10 ASO TE Bi O BU E ACET SOA 2013 E HT M 2 5 11 VAD
92. LVAD Jarvik7 SyncardiaTAH LVAD BTT 2000 TE Bi JOE E AETR 2013 a Jarvik 2000 b HeartMate II X000000 c EVAHEART d DuraHeart e HVAD 2 Inlet Area Flow rate up to 2 5 Umin Actual Size A 9F 12F pump motor Outlet rea a Impella b TandemHeart Ed 3 WER aI OREM E ARBRIT SAT FAT 2013 2011 2012 a Jarvik 7 b AbioCor 4
93. VAD e Wd RAE 3 6 D LVAD backward PH pulmonary hypertention f YE E 7g 5 6 Wood T LVAD
94. PCPS tS U 3 AUS L VAD Profile 2 BTC BTC likely LVAD Profile 3 n HE LVAD Profile 4 k INTERMACS Profile 4 Profile 3 A Profile 4 Profile 4 WER aI OPE E ARBRIT SOT 2013 2011 2012
95. VAD S B n A VAD 225279 27 Borg 11
96. 25 BMI 8 cardiac cachexia c B reverse remodeling BNP JE ACE II ZRA ARB HA
97. Bae 259 LVAD 259720 3 1 5 AR II AR LVAD LVAD AR 261 263 AR 1 LVAD LVAD
98. 218 PAD VAD PAD VAD 219 VAD 09 VAD io
99. 5 Exertion intolerant 6 Exertion limited 7 Advanced NYHA III AHA ACC Stage A Stage B Stage c Stage DJ NYHA Ml IV INTERMACS J MACS 7654321 2 1 MEO E ABNF BAA FTT 2073 House bound Walking wounded 4 2010 11 16 3 amp 1 2 3 ZI BSA NYHA IIl IV IV D ACE BASSE ARB 6
100. PUN 3 Ho 2 CDC 4 fa Gram Gram Gram 245 240 b 1 3
101. 59 Doppler PFO 2 154155 PFO VSP b LVAD TEE b LVAD CORDS OMEN TV 152 ER Cy LVAD 1 1 2m sec 727 199 c de air
102. VAD deconditioning VAD LVAD M 280 22 _ VAD LVAD
103. Lower Shumway biatrial 303 bicaval E DAE bicaval 9 7 LVAD L bicaval bicaval 1 2 Joao FARIREBWS LK KGHR WA OMICS BRI ZEWEOSL KEIREWEL 3 FOMOWREAI CE DDS warm blood cardioplegia 3 4 2 LVAD LVAD reverse remo
104. LVAD 6 TE Beas ORM E BRIT SAL BAF 2013 2011 2012 6 HAL LVAD O 1 50 LVAD destination therapy DT B TE Bi JOE E ACET SOA 2013 BIT VAD B LVAD B
105. HeartMateVE REMATCH HeartMatell DT DT LVAD 25 DT BTC LVAD DT DT 29 bridge to bridge BTB LVAD VAD VAD VAD
106. 3 ACC AHA BY I TIII LVAD 2001 HeartMate VE REMATCH study Randomized Evaluation of Mechanical Assistance for the Treatment of Congestive Heart Failure 2009 HeartMate II DT DT 2 8 LVAD 23 96 LVAD 58 2002
107. d IABP PCPS ECMO VAD LVAD IABP VAD IABP IABP LVAD VAD VAD 97 bridge to decision BTD LVAD 9 PCPS
108. VAD 1 2 3 1 7 HAH LVAD LVAD VAD 326 20 X 18427
109. BVAD LVAD TR 19295 2 9 TR TAP 83 O LVAD HEOR 2 5 CVP gt 15 18mmHg LVAD 2 L min m Wink RVAD 59 2 P VAD Thoratec fl VAD VAD 2
110. LVAD AC DC 3 3 3 9 VAD RD 3 3 4 T PT INR XS PT INR
111. CT CT 1 alc 2 PT INR XS PT INR 3 3 3 5 LVAD LVAD
112. LVAD BB 3 LVAD 2011 2012 1 2013 AM LVAD LAL 199
113. VAD BIT DT DT nm 80 60 6 L 80 80 6 RB 2 m5 900 D VAD EW VAD VAD
114. 99 81mg 243mg 100 mg 300mg Du WER Gem OREM E ARBRIT EA FI 2013 2011 2012 RS VAD 1 1 6 12 2 3 6 CPX CDTI QOL SF 36 EuroQol MMSE TMT B
115. PT INR 2 0 2 5 2 3 3 HeartMate II 20 BIA TIA YES SIE Pere bt sk LZ 8 ix LAD I
116. 3 1 l 3 1 1 PT INR XS PTLINR PT INR 2 9 1 8 D CT D PT INR PCC K FFP
117. BVS 5000 ABIOMED AB5000 ABIOMED EXCOR Berlin Heart CentriMag Thoratec SynCardia Systems TAH SynCardia Systems AbioCor TAH ABIOMED Novacor LVAD WorldHeart HeartMate IP LVAD Thoratec Jarvik 2000 Jarvik Heart tt HeartMate II Thoratec tt EVAHEART DuraHeart HeartWare HVAD HeartWare TandemHeart CardiacAssist tt Impella ABIOMED PediPump Cleveland Clinic infant Jarvik Jarvik Heart tt PediaFlow VAD WorldHeart TE Beas JO REBEL CRIT SAA BAF 2013 gt 2011 2012 a VAD d AB 5000 e EXCOR 1 CentriMag LVAD VAD A VAD EXCOR Berlin 1 3 n DERAPE TSZ m L Heart 1e 1 2 x ig
118. QOL LVAD bridge to bridge 1 1 6 bridge to decision BTD VAD bridge to decision VAD temporary device TandemHeart Impella CentriMag 1 1 7 bridge to recovery BTR VAD reverse remodeling 3D BTR
119. 1919 100 VAD VAD EH Vm E p MRR OREM E ARBRIT SAT FI 2013 2011 2012 ll 7 am ile Li 1 1 VAD LVAD LVAD BTT
120. 79 Fontan GE 1 2 3 LVAD a BEE LVAD NYHA IV LVAD CRT AHA ACC Stage D INTERMACS Profile NYHA IV AHA ACC Stage D 3350 J MACS Profile 3 154 Profile 1 PCPS LVAD PCPS
121. 1 LVAD DT l B 4 CRT DT Ila C 5 VAD VAD VAD lla C VAD l C 6 LVAD
122. 99 f HE 50 7 Hi 41 2 59 10 VAD HEX ACE CRT HF B g
123. BTT BTR BTD DT LVAD 319 LVAD LVAD LVAD
124. 2 1 2 1 1 LVAD IABP VAD 79 VAD IABP 212 __ LVAD LVAD L
125. 2 2 1 LVAD 7 2 mm LVAD
126. 2012 41 81 85 288 McCahon D Fitzmaurice DA Murray ET et al SMART self management of anticoagulation a randomised trial ISRCTN 19313375 BMC Fam Pract 2003 4 11 289 Jackson SL Peterson GM Vial JH et al Improving the outcomes of anticoagulation an evaluation of home follow up of warfarin initiation J Intern Med 2004 256 137 144 290 Yang DT Robetorye RS Rodgers GM Home prothrombin time monitoring a literature analysis Am J Hematol 2004 77 177 186 291 Gardiner C Williams K Mackie IJ et al Patient self testing is a reliable and acceptable alternative to laboratory INR monitoring Br J Haematol 2005 128 242 247 292 Matchar DB Jacobson AK Edson RG et al The impact of patient self testing of prothrombin time for managing anticoagulation rationale and design of VA Cooperative Study 48 1 the Home INR Study THINRS J Thromb Thrombolysis 2005 19 163 172 293 Sobieraj Teague M Daniel D Farrelly B et al Accuracy and clinical usefulness of the CoaguChek S and XS Point of Care devices when starting warfarin in a hospital outreach setting Thromb Res 2009 123 909 913 294 Bhat D Upponi A Rakecha A et al Evaluating safety effectiveness and user satisfaction of home international normalized ratio monitoring service experience from a tertiary pediatric cardiology unit in the United Kingdom Pediatr Cardiol 2010 31 18 21 295 Dolor RJ Ruybalid RL Uyeda L et al An evaluati
127. TE Bi JOE E ACETA 2013 Interagency Registry for Mechanically Assisted Circulatory Support Japanese registry for Mechanically Assisted Circulatory Support The Japan Organ Transplant Network left anterior descending lactate dehydrogenase left ventricular assist device left ventricular assist system left ventricular end diastolic diameter left ventricular ejection fraction mitral insufficiency mitral regurgitation mitral stenosis National Heart Lung and Blood Institute nitric oxide New York Heart Association peripheral arterial disease prothrombin complex concentrate percutaneous cardiopulmonary support pulmonary capillary wedge pressure phosphodiesterase patent foramen ovale Pharmaceutical and Medical Devices Agency pulmonary regurgitation prothrombin time _ international normalized ratio quality of life right ventricular assist device Society of Thoracic Surgeons total artificial heart tricuspid annuloplasty transesophageal echocardiography tricuspid insufficiency tricuspid regurgitation ventricular assist device ventricular septal perforation 2 P pig
128. 281 MHS MR MR VAD BTR MR f VAD g TR LVAD JE TR TR DT h PR VAD PR
129. AbioCor TAH 2 LVAD 2A LVAD INTERMACS Profile 1 7 3 INTERMACS J MACS Profiles INTERMACS JJ_MACS 1 3 R3 INTERMACS Profile J MACS 1 VAD 2 3 LVAD 4 LVAD LVAD 2010 2010 11 16 G 4D ro LVAD
130. EH pu OF Ge pie LVAD BQ 2 LVAD Novacor LVAD HeartMate XVE LVAD 1200 16002 TandemHeart amp Impella LVAD 1 DuraHeart EVAHEART HeartMateIl 1 4 TEN x Jarvik 2000 HeartWare Ventricular Assist Device HVAD TAH TAH 4 1980
131. ICD CRT D 25 8 EEG EH VAD W SAAS b VAD
132. VAD 2 WITS VAD AbT bA VAD VAD 9 39 25
133. 5 PT INR i 2 0 3 0 2 5 3 0 133 134 LVAD VAD DS DuraHeart 9 EVAHEART FEE oD 9 LVAD VAD VAD HAH LVAD VAD LVAD VAD LVAD 2 3 7
134. CT D 2 5 12 VAD VAD MPR AIC Ko LDH fL LVAD VAD
135. HA 2 5 13 J MACS 2 3 5 mg dL 48 2 mg dL 90
136. HeartMate VE 2003 HeartMate XVE 2010 HeartMateII DT INTERMACS Registry J MACS Registry DT EBM HAR LVAD observationalstudy retrospective study historical control
137. 9 VAD 130mEq L Na 2 Na central pontine myelinolysis MEP CRER HA 1 Na 12mEq L Na 130mEq L pe MR OBM E ACETA FIY 2013 DSI PUY VRR CHS b IWIN 3 75 mg VAD C amp R RIC Na 108 21 6
138. TA LVAD 99 VAD p 3E HAD 63 WED 5 34 9 26 Becker 2005 29 Becker 15 4 Duchenne 3 3 Emery Dreifuss 1 1 83
139. 113 114 115 116 117 TE B PED LT E GRIEF EA 4 2013 119 120 12 122 124 125 126 127 128 129 130 13 132 133 134 135 136 137 138 139 140 Cool Seal system 2006 35 168 169 Sakaguchi T Matsumiya G Yoshioka D et al DuraHeartTM magnetically levitated left ventricular assist device Osaka University experience Circ J 2013 77 1736 1741 LVAD 2011 239 223 229 Westaby S Frazier OH Pigott DW et al Implant technique for the Jarvik 2000 Heart Ann Thorac Surg 2002 73 1337 1340 Frazier OH Myers TJ Gregoric ID et al Initial clinical experience with the Jarvik 2000 implantable axial flow left ventricular assist system Circulation 2002 105 2855 2860 3 Haj Yahia S Birks EJ Rogers P et al Midterm experience with the Jarvik 2000 axial flow left ventricular assist device J Thorac Cardiovasc Surg 2007 134 199 203 Frazier OH Implantation of the Jarvik 2000 left ventricular assist device without the use of cardiopulmonary bypass Ann Thorac Surg 2003 75 1028 1030 Tuzun E Gregoric ID Conger JL et al The effect of intermittent low speed mode upon aortic valve opening in calves supported wit
140. inflow cuff 18130 1310 2 HVAD 10 mm outflow graft HIE TA 93 28 HVAD 1800 rpm HVAD 2400 3200 rpm m CI 2L min m 20 APTT 40 60 sce
141. Profile 4 Profile 1 BTT 2 2 2 _ VAD VAD VAD BTD Profile 1 BTC Profile 2 49 2 2 Deos 221 VAD sous VAD INTERMACS 3545 25999 INTERMACS VAD 7 Profile 1 5 232 NYHAIV BE 6 7 23 HI REIS INTERMACS Profile 3 Profile 2
142. a KURA AS VAD b Al AT VAD E VAD VAD AI VAD AI VAD VAD 2 3 6 bridge to bridge VAD
143. 12 ARE TB REDDERE ARI PIT 504 FIT 203 147 2011 2012 T 1 48 1 e 148 2 e n 148 3 149 l rc 1 51 1 151 2 LVAD 154 1997 2 90 VAD BTT 2010 BTT 2004 Novacor LVAD 2
144. SBA EAE ABM AEIR Ge Sif A DON SAA STE ACT TAH GE VAD 2 2 1 1 paracorporeal VAD extracorporeal VAD VAD 1 2
145. VAD Profile 1 Profile 1 LVAD Profile 2 BTC VAD ICD Profile4 VAD DT LVAD INTERMACS Profile 2 Profile 3
146. 2 229 2 5 16 WT I T 9 2 5 17 T vo
147. 54 312 321 Kumar A Optimizing antimicrobial therapy in sepsis and septic shock Crit Care Clin 2009 25 733 751 viii Simon D Fischer S Grossman A et al Left ventricular assist device related infection treatment and outcome Clin Infect Dis 2005 40 1108 1115 Saito S Matsumiya G Sakaguchi T et al Fifteen year experience with Toyobo paracorporeal left ventricular assist system J Artif Organs 2009 12 27 34 Kawata M Nishimura T Hoshino Y et al Negative pressure wound therapy for left ventricular assist device related mediastinitis two case reports J Artif Organs 2011 14 159 162 3 Kinoshita O Nishimura T Kawata M et al Vacuum assisted closure with Safetac technology for mediastinitis in patients with a ventricular assist device J Artif Organs 2010 13 126 128 Kimura M Nishimura T Kinoshita O et al Successful Treatment of Pump Pocket Infection after Left Ventricular Assist Device Implantation by Negative Pressure Wound Therapy and Omental Transposition Ann Thorac Cardiovasc Surg 2013 Mar 26 Epub ahead of print Morito H Nishimura T Ando M et al Successful treatment of cerebral hemorrhage using computed tomography angiography in a patient with left ventricular assist device J Artif Organs 2012 15 90 93 Morito H Nishimura T Ando M et al Endovascular treatment of cerebral hemorrhage in a patient with a left ventricular assist device report of a case Surg Today 2013 May 16 Epub ahead of pri
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149. LVAD TEE 7 Valsalva TEE LVAD 83 162 AD AT LVAD
150. considerations ASAIO J 2009 55 598 601 Gregoric ID Bruckner BA Jacob L et al Clinical experience with sternotomy versus subcostal approach for exchange of the HeartMate XVE to the HeartMate II ventricular assist device Ann Thorac Surg 2008 85 1646 1649 2012 http www j circ or jp guideline pdf JCS2012 nohara h pdf 2012 10 Morrone TM Buck LA Catanese KA et al Early progressive mobilization of patients with left ventricular assist devices is safe and optimizes recovery before heart transplantation J Heart Lung Transplant 1996 15 423 429 2011 http www circ or jp guideline pdf7 JCS2011 izumi h pdf 2012 10 Kurihara C Nishimura T Imanaka K et al Spontaneous increase in EVAHEART pump flow at a constant pump speed during exercise examination Ann Thorac Cardiovasc Surg 2012 18 514 518 Kugler C Malehsa D Tegtbur U et al Health related quality of life and exercise tolerance in recipients of heart transplants and left ventricular assist devices a prospective comparative study J Heart Lung Transplant 2011 30 204 210 Wilson SR Givertz MM Stewart GC
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160. 0 LVAD BTT 2002 FDA destination therapy DT 2011 LVAD BTT 2013 DT LVAD LVAD DT 10 LVAD i LVAD 2012
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163. 13 ADL VAD VAD 4 amp 4 289 LVAD 8 QOL T9
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167. DR AEL LVAD CT LVAD LVAD LVAD Wee LVAD LVAD
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171. VAD LVAD LVAD BTC BTC 40 INTERMACS BTC 3 likely moderately likely unlikely LVAD 79 114 __ destination therapy DT LVAD 229 LVAD DT
172. VAD LVAD RVAD LVAD RVAD BVAD VAD Elia VAD AB5000 1d BTT VAD 30 2011 DuraHeart EVAHEART VAD BTT VAD VAD
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174. apy cardiac resynchronization therapy defibrillator cardiothoracic ratio central venous pressure destination therapy evidence based medicine extracorporeal membrane oxygenation ejection fraction estimated glomerular filtration rate fresh frozen plasma human atrial natriuretic peptide intra aortic balloon pumping implantable cardioverter defibrillator intermittent low speed Jm I ASMP AE SIMA EE PITA ES D OU E C Ae s SF I zm
175. deling v LVAD bridgetorecovery reverse remodeling 30 3 reverse remodeling 2 X 4 LVAD 1 13 3319 LVAD 3 LVAD LVAD HBR IMR B ACB i Harefield recovery protocol 39 LVAD Berlin 3 LVAD LVEF ARIMR 45 LVEDD 55 mm OB WER aI OREM E ARBRIT SAT FAL 2013
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