シンバイオ製薬（4582）
Contents
1.2. SAB Scientific Advisory Board SAB 10 400 3 10
3. 3 5 Weaknesses
4. 1 3 5 hared R search http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved a 4582
5. 1 2 1 2015 12 SR
6. http www sharedresearch jp Copyright C Shared Research Inc Al Rights Reserved 4582 Shared Research Report 2015 3 18 2010 23 919 60 18 240 76 3
7. 1 000 100 3
8. 2014 12 6 600 2015 12 2017 12 7 400 lt 9 100 SH ared R search http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved a 4582 Shared Research Report 2015 3 18
9. Sh ared 6 esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4582 Shared Research Report 2015 3718 9496 B 69 T NK 25 496 2 SR 2005 12 1 4503
10. 2005 12 Bendamustine Hydrochloride 2006 3 13AZ200010 2007 3 SyB L 0501 2008 8 SyBL 0501
11. hared R Search http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4582 Shared Research Report 2015 3 18 symbiosis
12. 2015 12 2016 12 2016 12 2016 12 2017 12 hared Search http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4582 Shared Research Report 2015 3 18 2016 12 2017 12 1 5
13. SR Inc SR Inc Email info sharedresearch jp http www sharedresearch jD Copyright C Shared Research Inc All Rights Reserved 3 31 12 03 5834 8787
14. MDS MDS http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved esearch lt Shared 4582 Shared Research Report 2015 3 18 MDS SyBL 0501 5 SyB L 0501 1971
15. 2012 2 Innomustine df Shared Gxcscarch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4582 Shared Research Report 2015 3 18 2014 11 2014 11 14 2 34 2 34 1 497
16. J GCA DIC TOKAI
17. 2011 3 2012 3 2015 hared Search http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4582 Shared Research Report 2015 3 18 2 BfArM Bundesinstitut fur Arzneimittel und Medizinprodukte 2015 12 81 2003 9 2008 8 IV R CHOP R B R B 274
18. NHL Non Hodgkin Iymphoma Diffuse Large Cell Type hared R search http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4582 Shared Research Report 2015 3 18 PFS Progression Free
19. 1 500 1 000 1 000 2 000 http www sharedresearch jp Copyright C Shared Research Inc Al Rights Reserved 4582 Shared Research Report 2015 3 18 SW Strengths Weaknesses SR Strengths Weaknesses Strengths 1
20. 2012 5 PMDA Pharmaceutical and Medical Devices Agency PMDA PMDA 6 700 hared R Search http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4582 Shared Research Report 2015 3 18 6 SyB L 1101 SyB C 1101 Onconova Therapeutics Inc MDS Myelodysplastic Syndromes
21. 2015 SR 2015 2 2020 12 900 2 600 SR 3 3 SW Strengths Weaknesses SH ared R Search http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved
22. OS Overall Survival hared R search http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4582 Shared Research Report 2015 3 18 Orphan Drug 10
23. MDS 7 800 MDS 3 200 1 4516 MDS 2014 3 9 692 38 1 2015 3 10 800 SR hared R Search http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved
24. SR Inc SR Inc Shared Researcn SR Inc SR Inc SR Inc SR Inc
25. B 2005 B 2 2007 2008 3 10 2010 10 2010 12
26. http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4582 Shared Research Report W 2015 3 18 2 725 49 4 1 945 73 9 SyB D 0701 HSP32 SyB 0702 2010 12 1 450 21 79 326 1 124 II
27. IL 2014 10 2012 6 MDS 1 2014 2 MDS RI BSC Best Supportive Care
28. 1 825 30 4 1 118 36 9 SyB D 0701 HSP32 SyB 0702 2009 12 1 191 26 9 1 191 TT 2009 3 2009 10 1 399 6 5 817 5 9 1
29. HLA hared R Search http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4582 Shared Research Report 2015 3 18 TT MDS 2015 2 FDA 2013 12 ASH American Society of Hematology I MDS
30. 2014 12 199 10 8 2005 12 5 2010 10 2010 12 3 2014 12 4 320 57 589 4 700
31. http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4582 03 5472 1125 2005 3 25 HP http www symbiopharma com index html IR IR a hared R Search http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved Shared Research Report 2015 3 18 105 0001 2 2 30 JASDAO 2011 10 20 12 IR httD www symbiopharma com ir index html IR Sh ad esearch W 4582 Shared Research Report 2015 3 18
32. IgG G Immunoglobulin G IgG SPA FDA MR Medical RepresentatIVe
33. 1 056 1 6 1 303 1 681 189 16 8 215 1 110 1 601 1 116 1 605 http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4582 Shared Research Report W 2015 3 18 2014 1 2 2014 2
34. 2012 389 2021 602 http www sharedresearch jp Copyright C Shared Research Inc Al Rights Reserved 4582 Shared Research Report 2015 3 18 7 691 105 0 1 614 138 0 1 195 112 4 1 994 166 9 389 111 5 602 154 8 2015 2 1 4519 2011 229 2012 247 2013 262 2014 262 4 700 2014 12
35. 4 4 Pejw h Pelr 1 12 2013 12 6 720 200 29 772 357 2 504 15 767 SR 2013 3 921 257 23 052 157 1 244 13 263 hared Search http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4582 Shared Research Report 2015 3 18 12 2005 3
36. 1998 ICH E5 http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4582 Shared Research Report 2015 3 18
37. POC SAB George Morstyn CMO FDA Robert Lewis iPS
38. 2015 12 MDS I MDS 2015 2 1 I 1 18 1 2 3 4 1 O 18 9
39. MR MR 120 130 30 40 MR SR M R hared R search http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4582 Shared Research Report 2015 3 18 2020 12 SR 2020 12
40. 2015 2 B IDEC Pharmaceuticals Corp Biogen Idec Inc Genentech inc 1997 11 IgG B CD20 SR 2001 9 2014 262
41. KOL Key Opinion Leader CRO Contract Research Organization
42. 2016 12 2017 12 2014 2 MDS I 2015 1 2015 12 MDS MDS
43. 2014 12 3 amp hared R Search http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4582 Shared Research Report W 2015 3 18 13 12 14 12 14 12 2Q E16 2Q cie 489 322 513 209 174 802 373 607 98 2 1 990 15 8 32 096 10 5 52 3 64 5 149 1 27 39 191 0 29 9 151 33 89 45 32 215 106 173 17 6 75 79 59 59 58 5 78 69 543 6 19 8 286 196 30 996 10 4 17 3 21 5 18 6 26 8 28 5 28 5 492 500 475 532 448 445 427 510 19 2 5 9 18 79 6 5 9 0 10 8 10 1 4 3 100 6 155 29 92 6 255 39 257 99 55 6 114 59 84 0 341 466 386 488 416 231 320 337 1 311 352 460 376 414 454 259 228 170 1 308 s 353 461 377 414 455 261 228 172 Bl
44. ec HH 2010 10 2010 12 2010 12 2014 12 SR 4 cd ml 4 2008 8 _
45. http www sharedresearch jD Copyright C Shared Research Inc All Rights Reserved 4582 Shared Research Report 2015 3 18 09 12 10 12 11 12 12 12 13 12 14 12 6 Pc 211 754 2 074 1 659 1 677 1 266 2 4 116 117 411 1 332 314 FCF 1 2 215 870 2 194 2 069 3 010 952 2 963 663 4 611 4 057 544 A 4 7 8 9 8 13 B 3 14 12 3 109
46. B CD20 B B 2008 1 2008 8 RI 1 4901 MDS MDS 11 000 60 2008 9 000 2008 2 781 2014 MD
47. AMGen Applied Molecular Genetics 1993 5 2008 2 10090 CCC 2005 1 4568 JASDAQ 4557 1 4282 SBI 1 8473 1 10 2005 12 2008 9
48. 50 2008 12 15 2010 10 2010 12 2014 7 SH ared R Search http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved a 4582 Shared Research Report W 2015 3 18 TT TT TT
49. 21 1 3 5 15 85 0 893 9 9 370 33 5 hared R Search http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4582 Shared Research Report 2015 3 18 523 20 3
50. Astellas Deutschland GmbH 2007 4 4 2008 8 InnoPharmax Inc Cephalon Inc
51. I SyB L 0501 IT 2010 10 2010 12 100mg hared R Search http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4582 Shared Research Report 2015 3718 9 696 8 096 V2 5 796 Oak 5 196 2 6 1 2 1
52. 2012 9 50 565 2014 7 MDS MDS MDS MDS 2012
53. SR 10 1 10 1 2013 R amp D 2006 2008 67 1 469 IL 19 7796 909 6 BIOtechNOW 2004 2011 1 6 79 12 1 2 459 649
54. 1 MDS MDS hared R search http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4582 Shared Research Report 2015 3 18 2 2016 12 2017 12 http www sharedresearch jp Copyright C Shared Research Inc Al Rights Reserved J W 4582 Shared Research Report 2015 3 18 2014 12 2015 12 2017 12 3 14 12 15 12 16 12 17 12 EL
55. 500 MR 40 1 500 SR 2020 12 900 2 600 Shared Gxcscarch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4582 Shared Research Report 2015 3 18 2005 3
56. 5 POC 1 SAB
57. 2016 12 hared R esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved a 4582 Shared Research Report 2015 3 18 2016 12 2017 12 700 SR 300 350 B R CHOP
58. R CHOP 4 65 I 2012 3 IL
59. 975 980 1 955 1 870 626 802 247 280 25 39 6 28 5 893 937 91 6 95 6 370 404 646 657 2 452 5 713 397 2 481 5 715 401 2 485 SR 1 870 4 3 2 452 2 481 2 485 1 870 3 6 1 767 20 4 103 78 2 2014 12 1
60. 114 1 601 1 729 1 605 1 733 hared R Search http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4582 Shared Research Repot 2015 3 18 09 12 10 12 11 12 12 12 13 12 14 12 1 191 1 450 1 883 1 955 1 532 1 955 26 996 21 7 29 8 3 9 21 6 27 6 238 1 224 1 362 1 214 1 428 1 191 1 212 658 593 318 527 100 0 83 6 35 0 30 3 20 8 26 9 1 399 1 825 2 725 2 293 1 999 1 830 117 59 125 89 144 8 117 3 130 4 93 696 208 613 2 067 1700 1 681 1 303 8 20 13 56 7 114 215 26 38 85 37 35 22 214 638 2 095 1 729 1 601 1 110 2 0 5 0 3 4 4 4 4 4 4 218 6
61. 2014 12 10 2014 6 3 6 hared R search http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4582 Shared Research Report 2015 3 18 Eisai Korea Inc 2013 12 1 532
62. SR 5 500 6 000 2012 6 2016 12 2016 12 2017 12 2013 5 TT
63. SAB SAB 1 5 2010 12 3 3
64. 2015 2 2015 12 2016 12 2016 12 2016 12 2017 12 4 70 80 B 20 30 T NK
65. 75 http www sharedresearch jp Copyright C Shared Research Inc Al Rights Reserved 4582 Shared Research Report 2015 3 18 _
66. 10 400 3 10 17 10 1 1 5 3 5 2015 2 I 2011 7 1 Onconova Therapeutics Inc
67. cd 2014 12 156 2015 12 2015 12 273 2014 12 2014 12 1 823 1 624 199 2015 12 1 987 1 611 376 9 0 http www sharedresearch jp Copyright C Shared Research Inc Al Rights Reserved 4582 Shared Research Report 2015 3 18 1 886
68. SR 2014 12 2014 12 1 955 27 6 1 940 35 5 1 468 12 9 472 3 6 1 273 15 85 0 1 830 8 4 774 26 5
69. 5 6 SAB POC 5 POC POC 2 1 2 5 1
70. 2016 12 2017 12 2020 12 2008 12 2008 12 2015 12 2 452 2 481 2 485 2015 12 2017 12 2 300 3 500 hared R search http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4582 Shared Research Report 2015 3 18 SR
71. 2020 MDS 1 2015 1 2015 12 HMA IHMA 2015 12
72. SR MG VOYAGE GROUP SBS KLab
73. a HMA HMA 1 MDS 1 2014 8
74. 2020 12 8 500 10 000 900 2 600 2015 12 2017 12 3 2 300 3 500 2014 12 6 600 S R
75. 30 MDS 10 20 3 5 10 MDS S R MDS MDS IPSS In
76. 646 807 713 812 79 715 814 2 I 2014 2 I 2013 5
77. nn Tn 2009 3 SyB L 0501 2009 5 SyB L 0501 2010 9 Symbenda _ b bd h
78. 400 3 1 1 1 4523 http www sharedresearch jp Copyright C Shared Research Inc Al Rights Reserved 4582 Shared Research Report 2015 3 18 eeimntiTie hdvigory Bomrdi SAB SAB 3
79. SR CHOP R CHOP R B NCCN National Comprehensive Cancer Network ESMO Europe s leading medical oncology society R B
80. MDS MDS 2014 2 MDS BSC Best Supportive Care 299 199 100 BSC OS 8 2 BSC 5 8 P 0 27 299 184 629
81. 2014 12 2016 12 2 3 2 2014 12 1 25 20 100 100 1 666 666 500 000 000 300 Oak 34 2014 12 1 30 304 10 363 968 1 342 3 030 400 1 010 395 9
82. 2005 3 2014 12 69 6 41 http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4582 Shared Research Report 2015 3 18 10 17 4 10 17 2 3 3 5 3 7
83. MDS DNA 3 6 MDS MDS 2014 3 9 692 38 1 2015 3 10 800 http www sharedresearch jp Copyright C Shared Research Inc Al Rights Reserved 4582 Shared Research Report 2015 3 18 2014 12 3 2014 12 3 1 348 1 9
84. 2020 12 10 000 12 000 5 000 6 000 2016 12 2017 12 4 700 SR 4 500 5 000 7 100 700 2015 2 SR 6 000 6 500
85. 1 500 1 000 2008 8 SR 5 2 2015 2
86. 21 69 4 230 7 4 1 432 26 8 100 1 053 26 8 946 10 6 1 999 12 9 1 681 1 700 35
87. 11 500 4 600 1 200 SR 80 90 25 5 000 6 000 4 000 5 500 2 700 3 900 SR 2020 12 8 500 10 000 3 900 5 100 2020 12 900 2 600 1 000 1 500 SR
88. MDS 1 2014 2 MDS BSC Best Supportive Care 1 MDS MDS 1
89. 0S 8 5 BSC 4 7 P 0 022 60 3 7 39 FDA Food and Drug Administration FDA EMA European Medicines Agency EMA 2015 12 2012 6 MDS 1 2015 1 FDA EMA hared R Search http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4582 Shared Research Report 2015 3 18
90. 2012 http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4582 Shared Research Report 2015 3 18 2012 iPS
91. 1 2012 9 Baxter International Inc 50 565 SH ared R search http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4582 Shared Research Report 2015 3 18 3 2010 10 2015 2
92. 27 27 48 57 37 49 RER 2 1 10 8 6 62 3 3 2 4 2 1 13 11 8 66 42 50 78 82 53 164 4 261 4 263 7 256 5 502 7 687 7 454 1 309 330 306 182 124 278 196 207 143 23 52 59 73 44 39 205 178 646 599 251 488 2 2 5 4 3 2 2 2 5 4 3 2 207 180 651 602 254 490 4 060 4 083 6 606 4 873 7 336 6 764 3 378 3 711 6 025 6 025 8 059 8 331 3 348 3 681 5 995 5 995 8 029 8 301 2 666 3 309 5 413 7 146 8 752 9 868 27 97 200 4 054 4 083 6 606 4 900 7 433 6 964 5 61 17 125 33 3 902 2 314 4 559 4 540 6 163 5 692 SR Z MY
93. 2015 2 MD 3 MDS 2015 12 I MDS I 2016 12 2017 MDS MDS IPSS 1 O 5
94. 2020 12 SR 2020 12 5 000 6 000 SR 2020 12 15 000 18 000 hared R Search http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4582 Shared Research Report 2015 3 18 20 000 15 000 300 350 10 000 5 000 15 12 16 12 17 12 18 12 19 12 20 12 SR 2020 12 3 900 5 100 4 75
95. C 5 56 78 142 159 F CF NI A B C 217 655 2 165 1 650 1 739 1 053 4 121 3 916 6 311 4 240 5 294 5 092 SR 2012 12 2013 12 hared Search http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4582 Shared Research Report 2015 3 18
96. I 2008 12 1 630 2007 12 1 630 2008 8 1 497 868 hared R Search http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4582 W SR 09 12 Shared Research Report
97. 1 1 596 BNYM SA NV for BNYM Client Account MPCS Japan 1 396 1 2 0 8 SR 2014 12 1971 MIT MIT T4 1975 1977 1980 1993
98. 2000 2010 80 2012 2010 2014 21 100 2015 2019 23 000 2020 2024 24 500 1975 1980 1985 1990 1995 2000 2005 2010 30 000 25 000 20 000 15 000 10 000 5 000 1975 1980 1985 1990 1995 2000 2005 2010 4 013 4 741 6 635 9 297 11195 13 307 16 991 23 919 10 3 6 4 1 S55 8 8 9 10 5 13 3 18 7 SR 2012 7 691 2021 10 614
99. SAB 10 17 a 1 5 3 5 oo 3 2017 12 2 160 3 754 2 557 3 524 2016 12 2016 12 2017 12
100. MDS 125 MDS Myelodysplastic Syndromes MDS
101. MDS 1 2014 6 3 Eisai Korea Inc 2014 12 2 2014 12 2 975 20 3 2 070 2 0 960 35 19
102. 1 333 9 0 0 4 2 3 15 85 0 1 320 10 0 545 33 2 775 19 1 967 1 193 941 1 188 944 1
103. 2014 1 2 774 2 999 1 829 2015 12 2015 12 2014 10 2015 2 2015 12 2016 12 MDS MDS MDS 3 I
104. 4 320 7 100 6 700 700 19 200 4 320 OAI 2014 12 7 100 TT 2 T SR http www sharedresearch jp Copyright C Shared Research Inc Al Rights Reserved 4582 Shared Research Report 2015 3 18
105. 1 955 1 870 2919 2 148 3 754 2 160 1 303 2 452 2 390 3 005 2 525 3 492 1 110 2 481 2 419 3 034 2 554 3 521 1 115 2 485 2 422 3 038 2 557 3 524 15 12 16 12 17 12 18 12 19 12 20 12 Ce DE MDS MDS MDS SR SR
106. 60 1 2 14 7 8 36 14 39 32 20 1 2013 3 MDS MDS 1
107. J 4582 8 W 10 12 11 12 1 450 21 7 1 212 1 7 83 6 613 1 883 29 8 658 45 7 35 0 2 067 12 12 1 955 3 9 593 9 9 30 3 1 700 13 12 1 532 21 6 318 46 4 20 8 1 681 1 601 1 605 Shared Research Report 2015 3 18 14 12 15 12 1 955 1 870 27 6 4 3 527 65 6 26 9 1 303 2 452 1 110 2 481 1 116 2 485 EPS EPS DPS BPS g 112 19 131 19 131 30 634 30 634 59 3 143 6 90 6 69 3 36 3 68 6 365 4 345 3 254 7 239 5 208 8 4 016 6 511 4 840 264 6 591 4 213 7 178 5 421 7 634 7 290 22 17 14 9 49 27 48 57 37 49 1 13 11 8 66 4 2
108. 2014 6 hared R Search http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4582 Shared Research Report 2015 3 18 3 Eisai Korea Inc 1 2 2 http www sharedresearch jp Copyright C Shared Research Inc Al Rights Reserved 4582 Shared Research Report 2015 3 18 2015 12 15 12 14 12 15 12
109. 15 20 POC hared R Search http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved a 4582 Shared Research Report 2015 3 18 POC OWE
110. 2011 7 SyB L 1101 SyB C 1101 PF PF PFF PF PF FFP PP _2011 10 Symbenda FFP m FFP PPP FPP FPP PPP FFP mm FPP PFPP FFP Fm PF FmF PPP PPP PP PP hm FPP PPP FFP
111. 4 500 5 000 http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4582 Shared Research Report 2015 3 18 2015 2 B gt 7 100 700 aa2016 12 2017 12 I 5oE 4 700 6 700 4 2010 10 1 2010 12
112. 4582 Shared Research Report 8 W 2015 3 18 08 12 09 12 10 12 11 12 12 12 13 12 14 12 1 630 1 191 1 450 1 883 1 955 1 532 1 955 326 1 632 1 955 1 432 1 940 644 3 390 3 940 4 230 4 320 50 6 48 2 49 6 33 9 44 9 1 630 1 191 1 124 250 100 15 1600 1 085 1 446 1 872 1 930 1 486 1 908 30 106 4 10 26 46 47 238 1 224 1 362 1 214 1 428 73 1 75 0 69 7 84 8 73 6 37 0 36 1 34 6 28 7 33 1 238 1 434 1 322 1 175 1 550 1 630 1 191 1 212 658 593 318 527 1 497 1 399 1 825 2 725 2 293 1 999 1 830 252 323 343 365 413 441 479 868 817 1 118 1 945 1 438 1 053 774 377 259 364 415 442 505 577 133 208 613 2 067 1 700 1 681 1 303 SR 2008 12
113. 6 I 2015 2 MDS MDS II MDS MDS I 2013 3 MDS 1 2016 12 MDS MDS 3 200 2019 12 AN I bo 7 800 3 200 a2019 2020 12 TT 1 I I I SR hared esearch http www
114. R CHOP 275 45 PFS R B 69 5 R CHOP 31 2 p 0 0001 p 5 R B 2015 12 2011 11 I 2015 12 2016 12 7 100 1 5
115. Shared Research Report 2015 3 18 4582 sr_inquiries sharedresearch jp 4582 Shared Research Report 2015 3 18 oo 3 4 5 5 6 16 16 so 18 23 11 34 SW Strengths Weaknesses 36 38 5 42
116. 20 B 2011 5 31 2014 6 16 2009 12 30 2011 10 18 SyB L 1101 I SyB C 1101 MDS 1 SR 2015 2
117. Shared Research Inc All Rights Reserved 4582 Shared Research Report 2015 3 18 BSC Best Supportive Care HMA HMA MDS
118. Shared Research Report 2015 3 18 4 http www sharedresearch jp Copyright C Shared Research Inc Al Rights Reserved 4582 W Shared Research Report 2015 3 18 SyB L 0501 2010 10 27 IL 2010 1
119. sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4582 Shared Research Report 2015 3 18 MDS MDS IPSS 2 HLA Human Leukocyte Antigen MDS MDS 2015 2
120. 191 3 I 2014 2 I 2013 5 MDS I 2014 2 MDS hared R search http www sharedresearch jp Copyright C
121. 2015 3 18 10 12 11 12 12 12 13 12 14 12 1 933 2 338 1 927 1 785 1 883 1 955 1 532 1 955 2 696 16 496 20 596 9 596 E 2351 1 625 1 889 1 654 2 067 1 700 1 681 303 2 398 1 652 1 922 1 650 2 095 2 1 601 1 110 2 407 1 656 1 926 1 654 2 105 Z 3 1 605 1 116 2011 10 2011 12 http www sharedresearch jD Copyright C Shared Research Inc All Rights Reserved 4582 Shared Research Report 2015 3 18 09 12 10 12 11 12 12 12 13 12 14 12 3 902 2 314 4 559 4 540 6 163 5 692 219 1 701 1 953 300 1 100 899 6 162 148 273 207 165 125 97 191 297 268 245 426 4 218 4 213 7 178 5 421 7 634 7 290 7 7 7 8 8 22 18 31 32 34 34 47 12 16 22 28 33 20 13 22 17 14 9 49
122. 42 2 105 1 733 1 605 1 116 s s SR 2012 12 1 955 3 9 19 8 3 940 16 2 2 293 15 8 1 438 26 1 2011 12 2011 12 1 883 29 8 1 632 401 3 3 390 2010 12 64 250
123. 46 49 7 50 OM ii 52 1 52 CECT Aa 54 56 EE 56 cio 56 62 http www sharedresearch jp Copyright C Shared Research Inc Al Rights Reserved W 4582 Shared Research Report 2015 3 18 POC Proof of Concept POC 3
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125. 68 10 363 968 1 000 032 000 330 Oak hared R Search http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved J 4582 Shared Research Report 2015 3 18 2014 11 13 2014 12 2014 12 1 990 1 785 1 311 1 654 1 308 1 650 1 311 1 654 2014 12 205 1 990 2014 11 6
126. S 11 000 hared R Search http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4582 Shared Research Report 2015 3 18 MDS 1 MDS I SR 2015 2 MDS MDS 1 4516 2006 2011 1
127. Survival a POC Proof of Concept 309 2 000 10 0 3 B
128. ternational Prognostic Scoring System 1IPSS 1 2 4 MDS 1 MDS 2 2011 7 HH 800 SR hared R search http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved a 4582 Shared Research Report 2015 3 18
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