ナノキャリア（4571）
Contents
1.2.
3. NC 6004 I II OEP II
4. MediCelle Debiopharm 2011 3 2005 3 Debiopharm S A NC 4016 2009 3
5. 2015 3 2015 3 12 389 400 1 1 284 499 989 600 494 989 600 Sh aredd Mesearch http
6. 20 100 2K 180nm 1800nm 4000nm 7300nm 8000nm a 20 100nm i TD rm
7. Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 2014 3 2014 5 13 2014 3 OEP 195 103
8. SR Inc SR Inc Shared Researcn SR Inc
9. siRNA 3 2013 5 13 Regulus Therapeutics Inc RNA
10. Sh ared Kesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 86 93 457 1 SR Research Report 2015 3 19 1 10 1 1 1 000 000 000 1 100 Pt DNA
11. sh ared hesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 2014 11 2014 11 11 2015 3 2015 3 560 330 1 428 1 955
12. 2013 6 19 siRNA 3 Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19
13. 10 ADCM ADCM siRNA Active NanoFect 1
14. NC 6300 2011 9 NC 6300 K912 NC 6300 K912 24 Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19
15. EPR Enhanced Permeation and Retention Effect Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 EPR LEnhanced FETrTWEahiltY and retentiprn geTfct 5OO OO 1 LEPTILH Et LL Per er 1 EL EET os mt 2 a a 1 NanoCap 2 Medicelle
16. 2014 6 3 SsiRNA NanoFect siRNA
17. Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19
18. NK105
19. 2009250393 2013 10 2013 10 21 2013 10 7 1 268 900 1 268 900 1 268 900 1 257 460 2013 10 11 2013 10 7 1 4063
20. DDS Sh ared Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 2011 Ride 46 6 2 393 4 3 794 37 196 1 6 268 15 2011
21. q PEG 2
22. NanoCap NK105 1 4272 NK105 2002 6 http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19
23. CEO 1996 6 1997 8 1 4403 2001 1 TLO 2002 6 1 4272
24. 2013 10 2013 10 2014 3 37 2014 3 130 2013 9 Sh aredd Mesearch http www sharedresearch jp C
25. NC 6004 NC 6004 2006 5 1 Orient Europharma CO Ltd OEP NC 6004
26. NanoBiotix X NanoBiotix
27. siRNA siRNA NanoFect 2013 6 siRNA siRNA 3 2013 6
28. Abraxis Bioscience Inc DDS In Vitro In Vivo 1976 Debiopharm Debiopharm 1994 Sanofi Aventis Sanofi 1999 2004 Sanofi
29. I 1 b IH MD NC 4016 1 MD Anderson NC 6300 I
30. 2012 3 2012 3 1 4502
31. NC 6004 NC 4016 ADCM siRNA NC 6004 OEP
32. b TI I OEP II IND NC 4016 MD 1 NC 6300 K 912 I Sh aredd Mesearch http www sharedresearch jpD Copyright C Shared Research Inc All Rights Reserved
33. NanoFect Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4571 SR Research Report 2015 3 19 2015 3 15 3 14 3 15 3 6 lcD 326 146 472 673 228 0 46 6 26 3 42 5 102 80 182 223 67 290 1976 996 26 0 187 2 68 5 45 5 61 4 724 689 1 413 222 4 470 196 299 206 501 622 1 123 1 127 5 6 436 659 1 095 285 8
34. 2014 4 2014 4 2 2014 3 2014 3 471 466 1 126 1 174 1 104 1 176 1 122 1 198 1 30 67 32 75 NC 6004 NC 6300 pH Orient Europharma Co Ltd
35. IND Investigational New Drug PFS Progression Free Survival Sh ared hesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4571 03 3548 0213 1996 6 14 HP httD www nanocarrieLCO D IR IR info nanocarrierCO D Sh ared KWeSGaT ch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved SR Research Report 2015 3 19 277 0882 5 4 19 047 169 6550
36. 2008 525801 2013 5 30 NC 4016 IND NC 4016 1 5 29 FDA Food and Drug Administration 1 sh ared hesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 MD Phase I Unit II 1 2013 5 20 1 4403
37. 2014 5 NC 6004 2019 3 800 1 100 8 sSh ared 1 ch lp http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 1 nm 10 1 DDS Drug Delivery System
38. siRNA 3 NanoFect NanoFect A 201080038549 X 2015 3 9 2015 2 24 2015 3 2015 3 673 560 1 127 1 428 285 1 029 322 1 070
39. 1 2013 5 NC 6300 K912 IND 2013 9 20 2014 2015 3 2024 2025 3 NC 6300 K912 NC 6300 K912 DDS DDS 3 039 2009 1 593 2000 1 780 2018 669 2010 EvaluatePharma 1 100
40. JP J P Morgan Securities plc 2013 11 22 2013 11 25 Sharedd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 2013 9 30 364 352 33 600 397 952 6 300 404 252
41. Novosom AG pH CD240 Calando Pharma Inc IT 101 Calando Cyclocert TM Calando PEG Calando siRNA Access Pharmaceuticals Inc NC 4016
42. 1983 DNA 1 1
43. 5 Sh ared Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19
44. NK105 1 4272 2012 7 III NC 6004 Orient Europharma Co Ltd II 2013 2012 10 1 2013
45. Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 NC 6004 NC 4016 NC 6004 II 2012 3 2 4 1
46. 2012 11 Orient Europharma Co Ltd NC 6004 12 000 12 000 24 000 2013 3
47. 2012 3 2012 5 10 2012 3 346 310 7 334 2011 3 520 366 2011 3 550 398 2011 3 555 NK105 1 4272 2012 III NC 6004
48. 2013 6 2012 7 2013 10 2013 9 2013 10 8 651 11 418 9 069
49. DDS 3 039 2009 1 593 2000 1 780 2018 EvaluatePharma 1 100 Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 NC 6004 NC 6004 QOL Quality of Life
50. 3 2014 5 NC 6004 NC 4016 2 Sh ared GYcsea ch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 3 3 1 2
51. NC 6004 OEP 2014 2 2014 11 NC 6004 300 Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19
52. ADCM 2015 3 1 599 2014 6 2014 3 2014 3 18 Antibody Drug Conjugated Micelles
53. ML AL C 10 20nm Active NanoFect Active NanoFect NanoFect ADCM siRNA Active NanoFect Active NanoFect gt Active NanoFect gt
54. J P Morgan Securities plc 2013 10 28 2013 10 30 8 400 P E 1 7 700 700 J P Morgan Securities plc 6 300 840
55. NanoFect 3 A NanoFect NanoFect 2014 5 2014 5 19 Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19
56. 14 6 Phase 2 ND 2 Orient a N Europharma I ND OEP CT TT ET wmgs ces ETT leer ETT TT CC 6300 FfK 912 ee oe ss 6 1 30 Anti body Drug Conjugate Micelles ADCM 2014 2 2014 2 12 2014 3 31
57. II I I III TV 0 FDA FDA 2006 0
58. 80 2017 2018 3 2020 2021 3 NC 6004 2 272 2007 1 720 2008 905 2003 EvaluatePharma 1 100 NC 6004 19 800 Sh aredd Mesearch http www sharedresearch jpD Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 NC 4016 NC 4016
59. NC 6004 Orient Europharma Co Ltd http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 1 1 b IT MD
60. ADC Antibody Drug Conjugate DDS ADCM ADC ADCM ADCM 2015 1 29 pH
61. Alnylam Pharmaceuticals Inc Isis Pharmaceuticals Inc C RNA RNA siRNA 1 RNA 20 25 1 RNA 2 siRNA mRNA RNA 500 RNA 3 1 RNA
62. RNA RNA 2013 5 9 NC 6300 K 912 pH NC 6300 K 912 Sh aredd Mesearch http www sharedresearch jpD Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 2013 5 7 NC 6300 K 912
63. SR Inc SR Inc SR Inc SR Inc SR Inc
64. iPS COO Chief Operating Officer 2008 6 2007 12 2008 5 MG 1980 DDS
65. ET 4 CC 3 pH pH 17 TR 5 a 6 14 PCT SR Shared esearch lp http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 2014 3
66. 2014 3 2 2013 11 11 2014 3 2 2014 3 2 Orient Europharma Co Ltd OEP 326 228 0 501 267 71 436 267 437 268 Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19
67. Orient Europharma Co Ltd 1 II 2011 7 II Sh ared hesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 NC 4016 1 II NC 6300 2011 9
68. PI b I MD NC 4016 I 2013 12 MD Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 NC 6300 2013 5 1 9
69. Antibody Drug Conjugated Micelles ADCM Fa Sh ared hesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 68 93 457 1 SR Research Report 2015 3 19_ 2014 3 10
70. Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 DDS DDS GMP Good Manufacturing Practice 1International Conference on Harmonization ICH
71. 2013 6 2013 6 25 NC 6004 NC 6004 Orient Europharma Co Ltd OEP NC 6004 I I OEP 6 24 TFDA Taiwan Food and Drug Administration Sh aredd Mesearch http www sharedresearch jpD Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 2013 6 24 NC 6004
72. DIC TOKAI
73. NC 4016 I Sh ared hesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 MD The University of Texas MD Anderson Cancer Center NC 6300 2013 5 1 IND PMDA 1 4523
74. 2013 2 2013 2 18 NC 6004 2013 2 13 NC 6004 2013 2 7 NC 6004 Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 2013 1 2013 1 16 NC 4016 http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 1996 6 CEO
75. DDS 2015 3 1 2015 3 1 57 150 100 2 409 8 9 E 7974 234 7 8 382 277 84
76. 2012 3 1 700 2 025
77. 2014 3 9 069 2007 3 2014 3 http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19
78. 3 NC 6004 NC 6004 NC 6004 Orient Europharma Co Ltd OEP Phase OEP OP Nano NC 6004 2016 2014 6 23 1 4523 IE7974
79. pH DDS ADCM Antibody Drug conjugated Micelle 3 amp sSh ared lesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 14 3 15 3 15 3 4 Plc Te pe cle Te pe cle 4Q 150 176 119 28 57 254 47 53 3 673 1430 2 96 4 16 7 83 9 62 0 44 7 60 1 42 5 98 125 53 14 27 177 9 209 9 14 9 51 19 72 4 41 2 82 9 65 2 71 4 448 48 9 47 4 69 6 19 2 375 349 336 352 409 303 423 151 8 172 2 114 6 81 9 8 9 13 3 25 8 250 29 198 7 283 59 1266 7 717 59 119 19 894 1 277 224 283 339 382 126 414 1 127 6 190 246 197 462 461 312 190 285
80. siRNA siRNA 2010 9 2009 5 25 TLO
81. 461 190 462 191 NC 6004 Orient Europharma Co Ltd 1 2012 10
82. DACHPt 1 1 2
83. 21 563 2014 3 402 652 5 08 http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 07 3 08 3 09 3 10 3 11 3 12 3 13 3 14 3 4 Pc CF A 663 588 45 452 578 293 635 1 098 CF B 62 19 4 8 5 1 721 121 059 FCF A B 25 607 461 460 582 2 015 5 8 158 CF 1 143 643 75 97 1 449 1 924 2 327 9 581 A 8 15 16 16 16 18 7 B 11 14 2 4 19 20 27 C 6 78 1 29 48 30 41 54 FCF A B C 727 571 440 452 590 429 538 1 189 SR
84. 2013 1 siRNA siRNA 2011 9 NC 6300 2012 3 1 4523
85. 1mg kg siRNA 3 NanoFect 2013 5 2013 5 31 200980118842 4
86. NC 6004 NC 4016 siRNA ADCM 205 1 800 1 127 2014 3 1 123 285 1 094 322 1 113 http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19
87. NC 4016 I MD NC 6300 1 NK105 1 4272 ADCM Antibody Drug Conjugated Micelle
88. LFB Biotechnologies LFB rhFVIIa recombinant human factor VIIla VII NC 4026 2011 3 LFB 2011 7 20 2011 3 2012 3 2011 3 1 391 sSh ared lesearch lp http www sharedresearch jp Copyright C Shared Research Inc All
89. 2012 4 shared hesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 siRNA 2014 3 40 44 1 10 PE1 7 81 6 61 4 89 4 31 2 88 2 73 Cyntec Co Ltd OEP 1 55 1 41 1 38 0 77 SR 2014 3
90. Sh ared lesearch lp http Www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved ET 457 1 SR Research Report 2015 3 19 O 3 000nm 300nm 100nm
91. NC 6004 NC 4016 ADCM siRNA 211 224 16
92. 1 MTD NC 6004 NC 4016 Debiopharm 2011 3 Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 Debiopharm 2011 5 12 17
93. DNA RNA DNA RNA 1g
94. Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 ADCM Antibody Drug Conjugated Micelle E7974 ADCM 10 E7974
95. 2014 3 2006 3 2013 3 2012 3 2014 3 2007 3 2008 3 3 IPO 2011 3 2012 3 2013 3
96. 3 NanoCoat http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4571 SR Research Report 2015 3 19 20 100nm NanoCap NK105 siRNA ee Medicell NC 6004 2 NC 4016 NC 6300 AA ow N Re NanoCoat I Active Targeting
97. i 11 TLO TLO 7 10 I ini EE a a a
98. 2012 7 ADCM Antibody Drug Conjugated Micelle siRNA ADCM 2014 6 E7974 E7974 ADCM
99. 2013 6 NC 6004 I II TFDA Taiwan Food and Drug Administration 1 II Hydration Hydration NC 6004 NC 6004 7
100. NK105 1 4272 ADCM Antibody Drug Conjugated Micelle siRNA Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 NanoFect
101. NK105 1 4272 2012 7 III NC 6004 5 OEP 2013 6 OEP I 2013 6 PI b I NC 4016 2013 5
102. AUC NK105 I 2010 8 I 2012 7 III II III NK105 380 2 2015 2016 3 NDA New Drug Application NK105
103. Debiopharm 1 2011 3 Debiopharm 2012 3 Debiopharm NC 4016 48 28 8mg m 1 I 2013 12 MD 20 2014 2015 3
104. OP Nano Sh ared hesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 OP Nano GMP Good Manufacturing Practice OP Nano OP Nano gt NT 1 000 2016 12 8 900m lt Huwei Yunlin OP Nano 2015 3 NC 6004 2013 6
105. NC 4010 2006 7 TLO 2007 2 TLO pH 2007 10 Debiopharm S A NC 4016 2007 11 NK105 II 2008 3 2008 4 TLO 2008 9 Orient Europharma Co Ltd NC 6004 Sharedd Mesearch http www sharedresearch
106. 1 b TT MD Sh ared hesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 NC 4016 I 2013 12 MD Anderson NC 6300 I 2013 9 NK105 1 4272
107. OEP 2012 11 OEP OEP NC 6004 OEP OEP OEP 800 OEP OEP OEP
108. 2012 7 2013 9 25 Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 2013 9 24 NC 6004
109. 100nm 100nm
110. 1 Rituxan MabThera Roche 5445 2 Avastin Roche 4763 3 Herceptin Roche 4728 12 Tarceva Roche 1126 13 Taxotere Sanofi 1023 14 Sutent Pfizer 950 15 Zoladex AstraZeneca 943 2013 2000 16 Sanofi 2008 20 2010 2003 DDS 1990 DDS
111. 100 233 130 472 26 3 0 688 926 1 123 2013 3 527 225 211 1 095 432 1 114 484 NK105 1 4272
112. 2014 3 31 http www sharedresearch D Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 i i 21 a 12 a NK105 a a 10 oo 8 TLO 23
113. SR tnc 3 31 12 03 5834 8787 http www sharedresearch jp Email info sharedresearch jp Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved
114. 2014 3 DNA Sh ared CsCdar ch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 997 99 457 1 SR Research Report 2015 3 19 DNA pH pH7 pH pH7 pH7 pH7 35 pH RNA DNA
115. 24 270 727 Sh ared hesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 2014 3 3 2014 2 12 2014 3 3 2014 3 3 Orient Europharma Co Ltd 444 121 1 785 361 633 355 633 356
116. 9 069 http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 2008 2008 9 4 116 75 Cyntec Co Ltd 2010 6 4 819 100 2011 10 11 000 290 2012 11 12 000 690 2013 10 33 600 8 651 2013 11 1 625 418 J P Morgan Securities plc 2014 3 2 285 2 19 278
117. 2024 2025 3 NC 4016 I SR Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 NC 4016 2 272 2007 EvaluatePharma 1 100 NC 6300 K 912 DNA
118. Orient Europharma Co Ltd OEP OEP OP Nano 1 NT 29 500 000 NC 6004 OEP 2012 11 OP Nano OEP NC 6004 NC 6004
119. 1 2014 5 ADCM Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 Active Targeting 3 WW E7974 2014 6 1 4523 IE7974 E7974 1 E7974 ADCM
120. 10 E7974 2014 6 2 2 1 E 7974
121. DDS DDS QOL http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 DDS C 60 DDS amp
122. I MD NC 6300 2013 5 I 9 ADCM Antibody Drug Conjugated Micelle siRNA 2014 3 1 2013 8 9 2014 3 1
123. 2013 5 NC 6300 K 912 1 2013 5 NC 4016 1 2013 6 NC 6004 Ib I 2013 6 Orient Europharma Co Ltd NC 6004 2013 10 amp 2014 12 2014 12 12 2015 1 1 2013 10
124. IND NC 6004 6 21 FDA Food and Drug Administration MD II 2 2013 6 20 1 4063
125. Medius Associates 2001 0 5 1 5 109 II 8 gt 1596 III 10C 20 2209 sSh ared lesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 SW Strengths Weaknesses 30 2014 5
126. ADCM Antibody Drug Conjugated Micelle siRNA 2012 7 2013 10 2013 9 2014 3 416 466
127. 2015 2012 7 INDA gt 2018 hf 0 2019 Ip mp lL lIPIb I 2020 2014 5 PI a 2020 2012 10 _ P 1 2024 2 PI 2024 NK105 NC 6004 NC 4016 NC 6300 4 siRNA ADCM NK105
128. 5 460 JP P Morgan Securities plc P 840 P Morgan Securities plc P 5 460 6 300
129. 11 216 8 916 2013 11 2018 10 2 300 2013 11 2018 10 NC 6004 NC 4016 siRNA ADCM Antibody Drug Conjugated Micelle 2013 9 2013 9 30
130. 2014 7 2014 7 16 pH pH pH 2013 9 1 NC 6300 K 912 pH DDS ADCM
131. Sh ared hesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 PEG
132. Dach DNA DNA CHOP
133. NK105 1 4272 2012 7 III 2 2014 3 3 2014 1 31 NK105 2015 NC 6004 Orient Europharma Co Ltd AA ER DR RE TO 2014 1 Eu 1 2012 10
134. 2015 3 389 0 979 500 495 DDS siRNA 2013 5 Regulus Therapeutics Inc microRNA RNA RNA RNA RNA 20
135. Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 RNA RNA 2010 10 1 W 2012 7
136. OEP 2013 9 OP Nano OP Nano 29 5 2016 12 Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 2012 8 31 TFDA Taiwan Food and Drug Administration IDB Industrial Development Bureau Ministry of Economic Affairs NC 6004
137. Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 pH pH NC 6300 K 912 NC 6300 K 912 pH
138. 1 029 1 929 1 070 1 970 OEP NC 6004 NC 6004 NC 4016 ADCM Antibody Drug Conjugated Micelle siRNA
139. 3 2017 2018 3 2018 2019 3 OEP II IND I 2012 10 1 20 2014 2015 3 2020 2021 3 1 2014 5 1 b T MD
140. Debiopharm 27 26 29 289 27 26 2008 3 Debiopharm 148 56 NK105 101 38 2009 3 Debiopharm 229 65 Orient Europharma 119 33 6 2010 3 2010 3 26 2010 3 2010 3 Debiopharm 55 479 14 11 28 2 http www sharedresearch jp Copyright C Shared Research Inc All Rights Rese
141. CJ Abraxis BioScience Nasdaq ABII DDS 2005 AstraZeneca 2009 3 1 500 2008 3 3 600 NK105 SR DDS AstraZeneca Teva EGFR Roche Genentech
142. 2011 9 290 2011 3 2011 5 12 2011 3 NK105 1 4272 II III 2011 2 21 III 2015 I 2010 2011 II NC 6004 Orient Europharma Co Ltd I II
143. DNA 2 RNA 1 RNA mRNA RNA DNA RNA RNA RNAi RNAi siRNA RNA RNAi PTGS SIRNA RNA RNA RNA RNA RNA
144. 1967 Bristol Myers Squibb Sh aredd Mesearch http www sharedresearch jpD Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 1 II III IV T
145. IND 1 NC 6300 K 912 1 5 7 PDMA 2013 4 2013 4 4 NC 4016 2013 3 21 NC 4016 2013 3 2013 3 21 NC 4016 2013 3 1
146. Orient Europharma Co Ltd OEP NC 6004 OEP 2014 1 IND Phase 2013 12 17 Sh aredd Mesearch http www sharedresearch jpD Copyright C Shared Research Inc All Rights Reserved
147. Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 2015 3 2015 3 330 2014 3 471 1 955 1 126 1 929 1 104 1 970 1 122 1 53 85 30 67 2014 3 2014 3 NC 6004 Phase I Phase Ib II NC 4016 Phase I
148. 150 2013 Wa Sh ared hesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 48 93 457 1 SR Research Report 2015 3 19 3 1 10 277 179 190 179 191 180 NK105 24 7 NC 6004 Orient Europharma Co Ltd OEP
149. NC 6004 NC 4016 siRNA ADCM 2013 3 238 2014 3 926 2015 3 1 271 Shared Gxcscarch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 2013 10 9 069 2013 11 2018 10
150. NC 6004 Orient Europharma Co Ltd OEP OEP 2 2014 3 2013 9 17 OEP OP Nano NC 6004
151. a Sh ared GYcsea ch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 2002 11 NC 4010 2004 5 NK105 1 2004 5 TLO 2005 3 Debiopharm S A NC 4016 2006 5 NC 6004 I 2006 6
152. 1 100 http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 402 632 40 263 200 1 100 2014 1 2014 1 14 NC 6004 NC 6004 NC 6004 1 09705599 0 2013 12 2013 12 26 NC 6004
153. 122 5 401 1 191 246 197 479 462 310 188 322 121 9 397 8 SR 2015 3 3 359 444 922 785 40 633 37 635 2 346 3 2014 10 12 594 3 2014 4 12 940
154. siRNA NanoFect ADCM NanoFect DDS sm 2015 1 2015 3 2 311
155. 1 110 1 118 2015 2 24 DDS siRNA siRNA active NanoFect siRNA
156. NK105 1 1 2004 5 2006 4 Drug Delivery System 24 1 2009 NK105 AUC 15 NK105 150mg sq m 210mg sq m 4 1 II 2007 11 II NK105
157. Eloxatin Sh ared hesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 68 93 457 1 SR Research Report 2015 3 19 2007 2013 2016 ohnson Matthey NCI Bristol Myers Squibb 2 DNA DNA
158. 457 1 SR Research Report 2015 3 19 SR NC 6004 NC 4016 NC 6004 NC 4016 II NC 6004 IND EE Phase llb Ill Phase IIb Phasei Phase IIb Phase Ilb Phase Ill IND ED 2008 3 2014 3
159. 2013 10 7 33 600 5 600 28 000 Sharedd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 2013 10 21 2013 10 23 0 90 1 00 P
160. 30 gt 75 siRNA http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 2015 2 1 4519 siRNA active NanoFect siRNA
161. siRNA 1999 Science RNA mRNA 1 RNA mRNA RNA mRNA RNA RNA RNAi RNA 20 RNA tRNA RNA rRNA RNA EE 300 20 10 300 Sh ared hesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 64 93 457 1 SR Research Report 2015 3 19
162. 2012 7 NC 6004 Orient Europharma Co Ltd OEP 1 2012 10 1 b IT Sh ared hesearch http www sharedresearch jp Copyright C Share
163. 3 NanoCoat 3 NanoCap 2 MediCelle
164. I Sh ared lesearch http www sharedresearch jpD Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 SiRNA siRNA small interfering RNA RNA mRNA RNA RNA siRNA siRNA AMD siRNA
165. SBS KLab J GCA
166. NanoFect 3 Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 A 3 120 140nm B 30 50nm siRNA ATP ATP Adenosine Triphosphate 3
167. SR Research Report 2015 3 19 4571 sr_inquiriesQ sharedresearch jp 457 1 SR Research Report 2015 3 19 oo 4 A 4 8 eo 17 eo 1 oo 22 Mut 30 RE 36 1 39 7077777 43 2 2 44 55
168. 11 2013 11 22 NC 6004 NC 6004 2010 517837 2013 11 18 NC 6004 NC 6004 098118350 Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 2013 11 14
169. 3 2 431 2015 3 2 346 2014 8 2014 8 20 NC 6004 NC 6004 NC 6004 NC 6004 NC 6004
170. 457 1 SR Research Report 2015 3 19 2013 12 5 2013 529476 NanoFect 1 B B 30 50nm siRNA ATP 2013
171. DACH Prolindac 2010 II HPMA Supratek Pharma Inc DDS SP1049C 2005 II Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19
172. DNA NC 6300 K912 pH pH NC 6300 K912 Improved anti tumor activity of stabilized anthracycline polymeric micelle formulation NC 630 M Harada I Bobe H Saito N Shibata R Tanaka T Hayashi Y Kato Cancer Science 102 1 192 199 2011
173. sSh ared 1 ch lp http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved w 457 1 SR Research Report 2015 3 19 ADCM Antibody Drug Conjugated Micelle siRNA ADCM ADCM Antibody Drug Conjugated Micelle
174. NC 6004 9 2 SM 8 ID TLO 24 6 NC 4016 Ya RT 3 lI 8 ee 11 TLO 8
175. 326 508 501 149 Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 436 152 437 2 346 NC 6004 Orient Europharma Co Ltd
176. 56 0 062 58 2 ES FPW 59 2 59 SN 62 i 82 eee 83 CE 83 83 83 oe 83 or 92 Sh ared CCT ch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4571 SR Research Report 2015 3 19 673 42 59 10 3 11 3 12 3 13 3 14 3 118 84 346 374 472 66 796 28 49 310 796 7 9 26 396 47 33 221 101 290 55 996 29 296 566 49 54 496 187 296 39 896 39 496 63 9 27 0 61 4 493 520 334 527 1 123 E 492 550 366 432 1 095 5 s 8 495 555 398 484 1 114 1 12 858 22 089 23 494 32 531 40 265 EPS 38 7 36 0 17 4 18 9 30 4 DPS 0 0 0 0 0 0 0 0 0 0 BPS 78 7 83 6 77 8 135 3 336 9 1 006 1 872 2 981 5 155 7 247 6 6 1 5 27 22 60 99 181 203 1 066 1 981 3 112 5 473 7 589 1 135 2 038 3 663 5 60
177. Antibody Drug conjugated Micelles pH Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 2009 7007877 2014 7 14 NC 6004 NC 6004 2009208481 2014 6 2014 6 26 NC 6004
178. www sharedresearch jpD Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 DDS siRNA 2015 2 13 2015 3 3 2015 3 3 2015 2 2 Antibody Drug conjugated Micelle Antibody Drug conjugated Micelle ADCM ADCM ADCM ADCM
179. 2013 3 2013 5 13 2013 3 Orient Europharma Co Ltd 373 7 9 526 2012 3 333 432 366 484 398 Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 Orient Europharma Co Ltd 242 NC 6004 1 1 035 237
180. NanoFect ADCM Active NanoFect 110 Sh aredd Mesearch http www sharedresearch jpD Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 2015 3 1 84 2015
181. 2008 3 5 3 IR httDp www nanocarrieLCcO D Ir index html IR 03 3548 0217 4571 SR Research Report SR MG VOYAGE GROUP
182. 2013 6 1 2013 6 PI b II 3 3 NC 4016 2013 5 I MD NC 6300 2013 5
183. 437 676 1 114 322 SR 2015 3 OEP 673 42 5 OEP NC 6004 DDS siRNA 2015 3
184. Rights Reserved 4571 SR Research Report 2015 3 19 07 3 08 3 09 3 10 3 11 3 12 3 13 3 103 263 354 118 84 346 374 472 4 19 154 0 34 6 66 796 28 496 310 796 7 996 26 3 92 68 247 71 51 125 273 182 12 194 106 47 33 221 101 290 11 39 74 096 30 196 39 896 39 496 63 996 27 096 61 4 729 647 638 540 553 555 628 1 413 704 8 246 2 180 4 458 0 655 9 160 2 167 9 299 296 717 453 532 493 520 334 527 1123 gt 6 3 7 9 4 1 2 106 244 13 46 1 4 31 35 12 215 727 492 524 492 550 366 432 1095 5 i 5 0 0 2 0 0 0 0 0 5 0 0 0 0 550 31 0 50 4 16 2 728 492 522 492 553 396 482 1 111 2 2 2 2 2 2 2 2 729 494 524 495 555 398 484 1114 6 6 SR 2007 3
185. Roche HER2 neu Genentech Roche Sh ared hes
186. jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 2008 12 NC 6004 I II 2008 12 Debiopharm S A NC 4016 2009 5 TLO 2009 11 2009 12 TLO 2010 8 NK105 1 2010 10 LFB Biotechnologies rhFVIIa VII 2011 3 Debi
187. 6 14 341 11 2 5 50 40 0 0 1 700 1 040 540 121 189 1 804 1 205 744 1 012 1 848 1 829 4 353 13 563 1 006 1 872 1 281 4 115 6 707 17 65 95 136 190 452 578 293 635 1 098 8 5 1 721 121 059 97 1 449 1 924 2 327 9 581 ROA 3 196 35 09 14 0 10 5 11 29 ROE 40 19 38 896 21 79 15 796 12 49 89 4 90 7 50 7 78 5 94 8 SR Shared esearch lt http www sharedresearch D Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 2015 3 19
188. 755 1 369 1 006 1 872 1 281 4 115 6 707 SR 2014 3 51 47 js NN 2011 3 2007 3 2011 3 2012 3 1 700 Pike 2014 3 540 2008 3 IPO 2014 3
189. 978 FDA DNA Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 Bristol Myers Squibb EL
190. d Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 MD NC 4016 I 2013 12 MD NC 6300 I 2013 9 ADCM Antibody Drug Conjugated Micelle siRNA NanoFect
191. earch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 2013 3 1 4403 63 579 30 79 43 303 20 9 37 436 18 0 23 250 11 2 13 379 6 4 TLO JST JST
192. opharm S A LICENSE AND SUPPLY AGREEMENT Termination Agreement 2011 7 LFB 2011 7 NC 6004 II 2011 8 2011 9 NC 6300 2012 3 2012 3 1 4523 2012 7 Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 2012 10 NC 6004 I 3 2012 10 Orient Europharma Co Ltd NC 6004
193. opyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 3 19 CMO CRO 1 2 3 3 1
194. rved 4571 PlcD 07 3 1 718 08 3 1 755 09 3 1 369 10 3 1 006 11 3 1 872 12 3 13 3 5 155 SR Research Report 2015 3 19 7 247 4 0 43 6 6 1 5 27 43 11 2 60 99 181 203 142 79 26 31 43 31 132 112 1 906 1 955 1 450 1 066 1 981 3 112 5 473 7 589 24 32 29 24 19 38 19 39 50 45 38 35 97 2 0 2 i 2 12 11 11 510 114 6 710 85 89 80 70 57 550 133 6 752 1 992 2 044 1 529 1 135 2 038 3 663 5 606 14 341 7 4 9 11 2 5 50 40 g 226 133 63 110 188 99 99 163 233 136 71 121 189 104 149 203 1 700 1 040 540 104 16 1 1 804 1 056 541 233 136 71 121 189 1 804 1 205 744 1 759 1 908 1 458 1 012 1 848 1 829 4 353 13 563 0 0 3 1 30 48 34 1 759 1 908 1 458 1 014 1 849 1 859 4 401 13 597 1 992 2 044 1 529 1 135 2 038 3 663 5 606 14 341 40 118 46 7 65 95 136 190 1 700 1 040 540 1 718 1
Download Pdf Manuals
Related Search