PDFファイル - 医薬品医療機器総合機構
Contents
1. HISCL 20007 1 R2 2 Oo G Il 1 AW512102E 2 Ri 50uL 10L 42 C 2 2 R2 30L 42 C 12. 30 Lot No R1 R3 1 2 3 uw Ww 3 AW512102E
3. J Ww Wisteria floribunda lectin WFA Kurokawa Piller a B N 0 M2BP Macrophage associated lectin Mac 2 585 7 N 8 12 1 WFA M2BP ng mL
4. 2
5. p ALP M2BP oO cE a O 7 et WFA Ci 0 1 Ca 2 20 C a 3 4 1 2 000xg 10 2 3 500 mg dL Fi18 5 mg dL C 20 2 mg dL 560 RF 550 IU mL
6. 1 Ds Lot No R1 R3 Lot No R1 R3 2 8 C R2 30 4 2 8 C
7. 1 HISCL 2000 ji 2 R1 gt R5 3 R1 R3 lt 4 R4 R5 R5 pH 5 200nL
8. 2 2 3 HISCL M2BPGi NC HISCL M2BPGi NC 1 1 00 1 00 3 00 3 00 2 M2BP 1 2
9. M2BP gt 1 AN FOF1 4 a FOF1 150 3 M2BPGi 54 14 2 C O 1 00 1 2 3 C O 1 00 4 0 822 264 321 95 0 776 0 863 0 735 1507204 95 0 669 0 794 0 974 114 117 95 0 927 0 995
10. MA2BP 5 M2BP WFA M2BP WFA MA2BP WFA
11. 1 HISCL M2BPGi NC HISCL M2BPGi PC 5 9 XAc SDnc Xpc SDpc Xnc 2SDnc lt Xpc 2SDpc 2 M2BPGi o 2 M2BPGi o 30 3 M2BPGi o 10 2 M2BPGi o 10 CV 15 4 0 10 20 00 9 HISCL 10 M2BPGi M2BP M2BPGi M2BP M2BP MM M2BP M2BPGi
12. 2 Ahmad 2 C O I C O 50 ll 30 1 FOF1 N 117 N 81 NE N 9 0 3 1 ECON Wilcoxon Rank Sum Test P lt 0 001 vs FOF1 P lt 0 001 vs F2 P lt 0 001 vs F3 P lt 0 001 vs F4 p 0 026 FOF1vs F2 P lt 0 001 FOF1vs F3 P lt 0 001 FOF1 Vs F4 p 0 009 F2 vs F3 P lt 0 001 F2 vs F4 P lt 0 001 F3 vs F4 Analysis of Variance ANOVA P lt 0 001 FOF1 F4 C O C O
13. Disodium 2 chloro 5 4 methoxyspirot1 2 dioxetane 3 2 5 chloro tricyclo 3 3 1 137 decan 4 yl 1 phenyl phosphate Mac 2 Binding Protein M2BP 2 E R1 M2BP R2 WFA 3 R3 ALP M2BP M2BP 4 R4 R5 Es CDP Star ALP M2BP WFA M2BP M2BP HISCL M2BPGi PC M2BP
14. M2BPGi 1 3 2 55D M2BPGi 54 45 HA FIB 4 9 2 F4 1 F4 F3 2 25 40 M2BPGi 6 1 8 2 AW512102E 5 F3 F3 6 2 C O 3 00 7 1 C O I 1 00 3 00 s 0 857 275 321 959 0 814 0 893 es 0 806
15. 100 700pL 4 4 R3 100nL 42 C 2 5 100 700pL 4 6 R4 50uL R5 100nL 42 C 5 300 650nm 3 2 2 3 HISCL M2BPGi PC HISCL M2BPGi NC 4 HISCL M2BPGi PC 4
16. 25 31 95 0 625 0 925 s 0 862 250 290 95 0 817 0 900 8 F3 F4 7 F3 40 F4 31 F4 0 676 48 71 0 806 25 31 0 575 23 40 M2BPGi 2 40 31 HA FIB 4 9 M2BPGi 2 6 5 M2BPGi l 1 HA
17. 3 2011 8 Abe Metal Association between Wisteria floribunda agglutinin positive Mac 2 binding protein and the fbrosis stage of non alcoholic fatty liver disease Gastroenterol 2014 9 Yamasaki K et al Elevated serum levels of Wisteria floribunda agglutinin positive human Mac 2 binding protein predict the development of hepatocellular carcinoma in hepatitis C patients Hepatology 60 5 1563 70 2014 10 Tamaki N et al Wisteria floribunda agglutinin positive human Mac 2 binding protein as a predictor of hepatocellular carcinoma development in chronic hepatitis C patients Hepatol Res 2015 Co 651 2241 1 3 2 TEL 0120 413 034 LOT W 5 1 5 1 651 0073 TEL 078 265 0500 4 AW512102E lt 2015 4 2 2013 12 1 SYSMex 22500AMX01930000 Mac 2 M2
18. 4 0 05 37 C 72 2 1 0 1s 1 121 C 1 5 2 0 1s 1 2 1 HISCL 2 30 C 2 8 C 2 12 HISCL M2BPGi R1 5mLx HISCL M2BPGi HISCL M2BPGi R2 3mLx HISCL M2BPGi R3 10mLx HISCL M2BPGi NC 1mLx HISCL M2BPGi
19. BP HISCL M2BPGi 1 2 3 4 1 HISCL M2BPGi HISCL M2BPGi R1 R1 2 HISCL M2BPGi R2 R2 WFA 3 HISCL M2BPGi R3 R3 ALP M2BP 2 HISCL HISCL R4 R4 2 HISCL R5 R5 CDP Star 3 HISCL 4 HISCL M2BPGi 1 HISCL M2BPGi NC 2 HISCL M2BPGi PC M2BP Mac 2 Binding Protein WFA Wisteria floribunda lectin ALP CDP Star
20. C O I 0 60 M2BPGi C O 1 2 70 3 30 C O M2BP 1 R1 R3 R4 R5 pH9 6 2 HBV HCV HIV 3
21. SGBNI2BBGHBG 5 HISCL 2 ek Cos Se HISCL R5 70mLx HISCL 2 HISCL 10Lx 11 R1 R3 12 Ms 1 Kurokawa T et al Purification and characterization of a lectin from Wistaria floribunda seeds Biol Chem 251 18 5686 93 1976 2 Piller V et al Comparison of the carbohydrate binding specificities of seven N acetyl D galactosamine recognizing lectins Eur J Biochem 191 2 461 6 1990 3 Ozaki Y et al Expression andimmunogenicity of a tumor associated antigen 90K Mac 2 binding protein in lung carcinoma Cancer 95 9 1954 62 2002 4 Sun W et al N glycans of human protein Cinhibitor tissue specific expression and function PLoS One 6 12 e29011 2011 5 Comelli EM et al A focused microarray approach to functional glycomics transcriptionalregulation of the glycome Glycobiology 16 2 117 31 2006 6 Kuno A et al A serum sweet doughnut protein facilitates fibrosis evaluation and therapy assessment in patients with viral hepatitis Sci Rep 3 1065 73 2013 7 Ahmad W et al Abrif review on molecular genetic and imaging techniques for HCV fibrosis evaluation Virology ournal 8 5
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