[ケーススタディ報告書] eDIPS-単層カーボン
Contents
1. 17 NIOSH CIB 65 JEXESME C OO RSR D fi BRE Ae SE LC SER 2 CNT2. SO OECD NanoSafety http www nanosafetyjp twitter GNanosafety ISO SO TC229 LEME 2013 1 IL 1 OECD OECD
3. a ae eDIPS CNT 2015 3
4. b B 2 B 3 CNT ng m ugim
5. c b 25 D 2 A CNT OPC ote 5m EET 27 D D MAT
6. 3 3 A 3B CNT CNT 12 nm Th
7. 3 CNT 0 03 mg m 2 2 A a CNT CNT
8. D CNT OPC 0 3 10pm CPC 001 1 um
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10. NEDO 3 3 CNT CNT TASC NEDO f
11. 9 D CNT 4 4 toe A 80 Shy 60 ot CO CH amp 40 diii E Uo 40 ao i20 a wT FE RRRNH LM eg e 20 ng m CNT XE 900 0 15 NUR 60 75 9 CNT I9 2 4 CNT
12. CNT DNA CNT 2 nm A MR SER 3 IO A B B REO ARERR CNT 28
13. a CNT 10 50 ug m ug m
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18. DNA Tal DNA CNT DNA 13 CNT in vitro dieu L FUERF E TASB 156 313 625 ea i TA100 TA1535 S 3 12 5 25 50 100 m TAI357 AIGH S9 iara S9mix Ws eo 1 NOR WP2uvrA HIVE ESM 0 3 CMC a ete ps gag P0 eras so ceu 90 Somix 6hr SRBE OECD TG473 E RIVIERA 9 30 bac wage S9mixC 24hr Ske u S9mix 6hr FE 18 14 ARE RIS CNT in vivo VOR eG ANA Nga 109 AA e 2 5 10 20 mg kg OECD TG474
19. ISO TS 19337 TASC CNT ISO TS 12025 Clk XTASC Dustiness Vortex Shaker 3 TASC ISO TC229 OECD WPMN OECD 2012 12 18 SHI ENV JM MONO 2012 40 36 OV BA Bi A 1 12 TASC
20. 5 CNT mg L 9 ed Een 48 0 42 0 94 100 mg L ECs0 48hr ee Daphnia magna 2 1 4 5 10 HCO 40 mg L M OECD TG202 Eu EM 0 0030 EC 235 dil T 29 i gt 50 21d lt d uc I 0 0095 30mgL GO RC Daphnia magna 0 030 Tween80 NOEC ni x 0 095 0 30 mg L i c CNT Y TH LCso Oryzias latipes Oryzias latipes 0 10 10 mg L Jp H 10 mg L gt 10 mg L 96 14 E des E TE A Uu IX
21. CNT enhanced Direct Injection Pyrolytic Synthesis method eDIPS eDIPS QUE UE 2 nm CNT 100 o N 5 MR TNR Es CNT
22. SG CNT CNT 9 CNT CNT I 1 1 eDIPS CNT chemical vapor deposition CVD 2
23. 4 OECD TG209 GLP IH 8 CNT EP p dad i Ez mg L EME US DR ARATE PAC 3 100 PCoam gt 100 OECD TG209 AUREUS mg L 3 A B ADME lt gt Liou 2012 52 SiO2 37 75 TiO 19 1
24. P06041 CNT Y SG CNT 4 CNT t NOAEL 0 13 mg m NOAEL SG 1 8 5 IO ARR 15 0 03 mg m CNT 0 03 mg m 0 03 mg m
25. f gt Email tasc3 ml aist go jp AE OH D NEDO 7 Meine P10024 41 National Institute of Ta Advanced Industrial Science RE ASO Research Institute of Single Wall CNT and Technology Science for Safety and Sustainability AIST NEDO IP10024
26. 2013 3 2014 11 2015 3 1 2 A RARER a b c B Fee REI CPP Ck m BERK DE 3 TE Be ae We ee oe ee ee ee 1 2 1 1 2 3 4 2 1 A B AR 2 A a b c B
27. 33 Do 1 2 3 4 5 6 7 8 9 10 11 12 wm 13 wm 14 wm 15 2011 CNT 2011 8 17 NEDO P06041 lt http www aist riss jp assessment gt International Organization for Standardization 2012 Technical Report ISO TR13329 Nanomaterials Preparation of Material Safety Data Sheet MSDS First edition 2009 lt http www env go jp press press php serial 10899 gt Q012 VAD ELIE iE International Organization for Standardization 2014 Technical Specification ISO TS 12901 2 Nanotechnologies
28. CNT DEEM ELILI ELS E BRR BTE SU CNT 2 79 OCHLRAOMERH OnSite BALLER Me lt P 8 O 9 I1 Jp E ZH S Yv25 JA PRBEIC SEO amp bx CNT ECNT Ex a Be uv UO E XE IECUV DLS DLS G D G D
29. NOAELy NOAELg 0 065 x 0 029 24 x x 1x 8 x 60 x 4 25 x 1073 0 3 BWg 0 3 kg BWy 73 kg EL SAs SAjJ BWe BWy tr x dayr Qr DFr BWy 1 Xo oe KX ix ty x dayy Qu DFy BWR UF 7 6 x 60 x z 0 189 x 107 73 1 3 0 03 mg m CNT CNT p D CNT
30. TASC E TASC E SDS CNT TASC 2015 2 a Ze HA 3 2 hk 3 E
31. TASC To ATF PEKA eDIPS CNT 3 20 12 12 TASC eDIPS
32. I3 5 X b nili D WAAT R EO condensation particle counter CPC 0 01 1 um OPC OPC o
33. CNT CNT CNT HEPA CNT f
34. 0331013 21 3 31 NIOSH General Safe Practices for Working with Engineered Nanomaterials in Research Laboratories 2012 5 RED 5C OE OUO RODET AEA COMETS S RB FAC Current Strategies for Engineering Controls in Nanomaterial Production and Downstream Handling Processes 2013 11 A Ux WE A CNT
35. 27 V Ho OF CH ne 2 E TASC gt RI are a CNT OA BEB EOE A E H NA gt As Ei 5 w my PRESET TEAR 8 NEDO 0 03 mg m 1 ae Ent
36. CNT 6 26 BOT P CNT 4 1 ARC CNT 3 7 c CNT
37. CNT CNT 1 SEM CHE CXS MEMET TEM A TEM Fe 1 SEM TEM X
38. NEDO X 1 10 mg L 1 mg L X 2 CNT 100 mg L Tween80 2 CI 3 BEB BERR TEREI ER ES ih x PRICEY C RCH OP URES C 5 b c HEUS CO rn ESIE D nTRETE
39. x5 9 CNT A c p BALF 6 0 2 mg VUR 5 88 12 0 4 mg OH 1 3 3 6 0 2 mg 1 1 3 04 mg GE 3 0 67 mg kg HS eS i 1 DR I 0 2 mg PL 2p
40. R lE SERE TEM ERRE BSA X 3 CNT CNT CNT CNT CNT E DK 31 P CNT
41. DT ISO TC229 E METI D s 0 w DNA deoxyguanosine dG 8 DNA FE OPC PBS REL ROS S9 SA SDS SEM SG SMPS SOD TASC TEM TG TGA TWA UV WG3 WPMN tail DNA Optical Particle Counter Phosphate Buffered Saline Recommended Exposure limitLimit Reactive Oxygen Species Supernatant of liver homogenates after centrifuged at 9000 X g Surface Area of lung Safety Data Sheet Scanning Electron Microscope
42. CB 3 CB 4 CB 4 2014 10 ARCO 7 O 1 C7 4 CNT MWNT 7 1
43. B CNT SD 0 2 3 0 2 mg kg 00H amp Cid 1 Jj CNT Sigma Aldrich MERRICK 21 c 80 E eB CNT OECD TG473 E 1 0 mg kg 5 yo FAV Te in vitro YE OECD TG474 J C Bin MWCNT 7 2 ICR ct SG 76 f 1 B bk CNT 0 04
44. 2 EE CAS 308068 56 6 3 CNT 1 eDIPS HUB CNT P CNT PS KS SI zj 1 83 1 2 nm TEM n 50 BET 877 7 m g N GID 116 21 95 ICP MS Fe 43 7 mg g Rb 0 056 mg g Zn 0 022 mg g Ga 0 012 mg g ICP MS
45. NG ay AA Aen Os M PERF ICH UL COSCO EBLUFARERE J CNT 38420 L BIC OV C e3ERERIC e fT BME ORE CADDO OW Ze RH FE CNT CNT CNT SDS
46. CNT eDIPS CNT 1 2 nm OPC CNT CNT CNT CNT CPC 10 nm cm
47. 90 734 1 E HLL 365 CNT SD 0 2 mg kg 0 2 DCA 1 Tween80 FA 2 CNT Wistar 0 08 0 40 mg kg 4 1 6 5H 1
48. CB Control Band HB EB 2 AER IU E CIB Current Intelligence Bulletin CMC Carboxymethylcellulose CNF Carbon Nanofiber CNT Carbon Nanotube CPC Condensation Particle Counter CVD Chemical Vapor Deposition DCA Deoxycholic acid DLS Dynamic Light Scattering DNEL Derived No Effect Level DOC Dissolved Organic Carbon PATER SAE ECso 50 Effect Concentration 50 8C ER HE eDIPS Enhanced Direct Injection Pyrolytic Synthesis method EB Exposure Band ARRA LN GREER SIVOT ES EDLE DD EHS Environment Health and safety ELPI Electrical Low Pressure Impactor ENRHES Engineered Nanoparticles Review of Health and EU NanoSafety Cluster Seven Framework Environmental Safety Programme Projects FID Flame ionization detector FMPS Fast Mobility Particle Sizer G D intensity ratio of G band to D band
49. 0 67 1 33 mg kg 6 1 0 4 mg ces Jp fim E BALF H CNT Wistar RHET v pZ 30 DNUS S is 180 g ij TUS m cx JA 363 0 2 0 4 mg 0 67 1 33 mg kg
50. 1 CNT 4 4 SG CNT 2
51. 1A CNT 3 E85 30 CNT CNT 23 NF SIV RE Be C FA E CNT E P E 2013 10 1 5 CNT CNT d 22 CNTIX HH CREE CNT i
52. 2 CNT sue ot pee LTR xm a p Pau ee BOD Doc az bci iia 96 mgC 2 lt gt BS VETE AMETE E DUE ii 28 i p idi 100 0 0 6 lt GLP gt OECD TG301F 28 100 0 30 GLP gt e OECD TG302C zi 100 30 0 c CNT Cyprinus carpio 30 pg L RWIE 60 BCF OECD TG305 GLP S 23 CNT We ntl CES BCF m B mg L lt GLP gt By 0 005 ini OECD TG305 Cyprinus carpio 0 050
53. fits Matsumoto 5 2012 CNT SD RIEF y MORRE 50 mg kg 1 4 LD gt 50 mg kg CNT SD 0 125 1 25 12 5 mg kg H 28 NOAEL 12 5 mg kg Xx 10 CNT Fy Miis MOE CCDD 14 akg ERER L UREZ L OECD TG423 e LD gt 50 mg kg p l Po Te ERIE BR KEZDE DRE 0 0 125 RREH 28
54. AGE DI eDIPS CNT X TM ie Ie ere ane dS CNT CNT Biss CNT SG CNT TASC Ka
55. CNT eDIPS H TASC eDIPS H 3 N di bm F ELE EAR KS CNT H CNT FARR CNT R f
56. CNT 100 nm Scanning Mobility Particle Sizer SMPS Fast Mobility Particle Sizer FMPS Electrical Low Pressure Impactor ELPI 0 5 10 um Aerodynamic Particle Sizer APS B
57. Crl CD SD Tween80 2p 3 Fm ite 2 PBS 2p 1 gt 1 BALE ERRI BALF HO 1 ERRE 4 v ie OO ee ae y A gs D cu wistar ABB 6 3H 17J mg m gt ERIE m 3 0 1 Triton ook AY MUVTAVIE ARRE CE AREE 8 OH dG ERREF 16 b 1 CNT
58. 2009 3 2012 9 C 3 0 001 0 1 mg m C 3 2014 1 SO
59. Eo f DY OECD TG203 GLP 0 OECD TG204 GLP E eh AS LCso gt 10 mg L NOEC 10 mg L 6 CNT ET iih mg eae me isle e Bu OECD TG203 Oryzias latipes Jf mg z LC ta 85 SEE E 3D 50 14d E F xis T 040 032 100mgL iub e rl eee TC204 Oryzias latipes 1 0 3 2 10 Tween 80 NOEC 144 mg L B CNT 28 OECD TG216 GLP
60. CNT 10 mg L 2 REC 44 10 mg L 72 25 10 mg L 21 AHRR CNT CNT 1 D is Ser 3 E ik Ra x A WAAR TE RERS UL AGES T a il a
61. CNT MITI D OECD TG 301C GLP BOD DOC 0 0 6mgC OECD TG301F GLP 100 mg L 30 mg L 28 DOC 0 BOD MITID OECD TG302C GLP YERL PORER 30 mg L 100 mg L 28 BOD DOC 0 CNT 1
62. NEDO P06041 CNT SG CNT 4 Avi NOAEL 0 13 mg m Tot 3 2 3 NOAEL amp 0 065 mg m SG CNT 1 8 5 13 0 03 mg m
63. TS 12901 2 B 10 SE rll lax lig FEZ LCVD HBC Gf 0 01 0 1 mg m EB 4 EB 1 2 EB2 3 EB 4 R
64. 30 LDs gt 200 mg kg NOAEL 12 5 mg ks 0 03 mg m PEL AR REEI CNT CNT ORRERI S DAER UEA mie DLE OTD 5 APT BE HO RO E C o EARR REK MARREK C35 2 5523
65. eDIPS eDIPS CNT TASC 2015 3 3 CNT TASC NEDO eDIPS eDIPS CNT TASC 3 CNT TASC INEDO gt E mail tasc3 ml aist go jp 2015 3
66. E 8 i p A GmgL ECs 72hr 3s AE NH SE 27 oh vies gt 10 RRE ER a RR 0 1 0 32 100mgL 2 LE mmis Sume lt GLP gt Pseudokirchneriella 7 1 0 3 2 10 HCO 40 NOEC OECD TG201 subcapitata Ad i 3 0 32 mg 2 b CNT Daphnia magna 48 OECD TG202 GLP 10 mg L 25 ECs gt 10 mg L Daphnia magna 21 OECD TG211 GLP Jp FA 0 003 0 30 mg L Ei zB SCA ECs gt 0 30 mg L NOEC 0 30 mg L
67. Lm AVE Lf 1007 Lm Lf HO 1 CNT CNT CNT eu FE WS NIOSH 29
68. G band D band HE GID GLP Good Laboratory Practice HB Hazard Band 38 HCO 40 HEPA HO 1 HQ IARC ICAM ICP MS ICRP TL 1B in vitro in vivo ISO ISO TC229 ISO TS 12025 JIS JWG2 LCs LDso LDH Lf Lm LOAEL MITI MWCNT NEDO NIOSH NOAEL NOEC OECD OEL 8 OH dG PEG 40 Hydrogenated Castor Oil High Efficiency Particulate Air filter Heme Oxiganase 1 Hazard Quotient International Agency for Research on Cancer Intercellular adhesion molecule Inductively Coupled Plasma Mass Spectrometry International Commission on Radiological Protection Interleukin 1 beta International Organization for Standardization ISO Technical Committees 229 Nanotechnologies ISO TS 12025 standard issued for Nanomaterials Quantification of nano object release from powders by generation of aerosols Japanese Industrial Standards JWG2 of ISO TC229 and IEC TC113 Measurement and Characterization Japan convenor 50 Lethal Concentration 50 Lethal Dose Lactase Dehydrogenase Penetration efficiency of filter Leak rate of the face piece Lowest Observed Adverse Effect Level Ministry of International Trade and Industry Multi Wall Carbon Nano Tube New Energy and Industrial Technolo
69. Qr X DFs ts X dayr SAR 1 NOAELy NOAELg X X X H R ty x dayy Qu x DFy UE SAn NOAELr mg m OEL NOAEL 3 mg m tg ty FJyvybBEOe b1 A440 RE B dayr dayg Fy BRUE bOWWAN A A HA Qr Qu 1 m7 Qa lt Bide 0 3kg ZRA L 0 189 X 10 Q ICPR 0 025 1 25L X20 DEF DF CNT DFR DFY SAR SA m UF 3 19 BW SASAm BWr BWg
70. 2B MWNT 7 2 CNT CNT 3 2 1 A gt OH B a BE b AME 100 mg L E51 30 mg L RHE HEJ 28
71. in vitro vwo CNT 2 CNT SG CNT 4 CNT CNT
72. C 3 A o0 00 1 1 OQ O tn tn tA RHR AQ A Ill J He C a VIRI AGA Moa roe so ear EE EE VISUS 618 ALERT 6 8 9 VAT COH UN 00 6610 14 PP tah ev bie IIR SUR RE ah CE TERR QR ee CREE S Ti 15 EC Tu CLE 98 9 0 RUE 979 929 9 i T 15 b PEPER OBHE enhn nh EE 17 c ee 17 d BREME IIIA 17 e _ 18 f IIIA 18 g eM MIHI 19 A ee 19 3 TE Be OE ree ee ee ee ee ee ee et ee ea er ee ee er EE ee ar er eae oe 23 a ea 23 A CE 23 B ee 24 x STA see IEE OEL
73. lt gt CNT ORO lt gt M CNT B CNT HUS CNT GD OS HUS CNT GD HUS CNT GD NEDO
74. CNT SG CNT 7 SG CNT SO 12103 1 AI test Dust TSI Dusttrak I1 8530 880 nm microAeth Model AES1 SG CNT 5 57 ok 100 7O 80 y 1 5x x w 60 IK R NN ee s 40 T y
75. BMCL NOAEL PED AAR EE EM TWA 2 BMDS2 1 2 E NIOSH 5040 0 001 REL 0 001 mg m 0 16 NIOSH 15 CNT mg m NEDO CNT 0 03 1 8 A 15 10 NIOSH 9 CNT CNF 0 001 Recommended Exposure Limit REL TWA ENRHES
76. 1000 mg kg dry soil Medicago sativa 5 g kg dry soil 0 EC gt 1000 mg kg dry soil 2135 An N IH z p lm ps 1 Q Z 4 9 SS _ EA A sic Aetna tae pis ye At ae Liao di i TEQUE Vo S fpi SOLE TAR EA a 1900 US TU soil GENI OECD TG216 C CNT DRAB TH FZK IURE 2 PREM UL 100 mg L ECs gt 100 mg L
77. Peasy bus A 1 25 12 5 mg kg Cr CDSD oom epee OECD TG407 Nc s p Au BEL BAT cae anomug ET SAY mm NOAEL 12 5 mg kg H c CNT 1 ug CNT NZW OECD TG405 172 CNT NZW TG404 9 545 1 72 0 5 g Hae HE E OECD 11 CNT
78. 44 nm CNT SG CNT 0 03 mg m lt 2 CNT Baytubes gt CNT Baytubes Baytubes IP Baytubes 13 NOAELg 0 1 mg m CHDK 1 Factor AF Baytubes OELy 1 5 E ORBE EAEXE A 0 05 mg m 20 Adjustment 6 OELy NOAELg x AF retained dose AF deposited dose 1 OELy 01x 5
79. CNT 0 0007 0 03 Derived No Effect Level DNEL 55 Bayer CNT 0 05 Occupational Exposure Limit OEL lt Baytubes gt TWA Nanocyl CNT 0 0025 lt NC7000 gt 1 1 299 2 3 amp SE SE 1 A CNT CNT optical particle counter LAF OPC ZIA 0 3 10 um
80. HJ CNT EF X PO6041 yE JN ve Zi 3m Ml se 24 Ff Be GFE DS AL E ES Du Bae AY BB lt E CNT 4 NOAEL 0 13 mg m 10 0 03 mg m3 3 HQ Ri En AER E 0 03 mg m 2 i EY 0 A REG a i E gt F
81. M VE e 3 6 ui Wistar 1 33 mg kg _ PT n 0 4 mg DE K AE BE 0 1 Triton 1 BARAK 0 2 0 4 mg L 5 3 JX DIX SE R T E RC AERE L 0 2 0 4 mg VCz 5f 8 OH dG 3 0 2 mg 0 4 mg 3 0 67 mg kg np io 0 2 mg VE 30 7 7 Sy Hp 90 90 0 4 mg WEHE 9 Wistar 36 3 65 1 33 mg kg 754 uH 7s4 04mg 0 2 0 4 mg VG L8 i 0 1 Triton Sppl Mmp12 754 i 0 4 mg 3 BALF IL 1B 1 1 0 2 mg kg 3 Sy HB 0 2 DCA 1
82. EHS WPMN 2013 3 13 CNT CNT CNT CNT 39 principal material Bis DH 2 CNT OECD 32 CNT x elc CNT 2015
83. Fe CNT 2 RENIE E D E PRIA rcu WY OPOFIEMHSD CO gt CH CNT FERE RKR RRR NIOSH CNT NIOSH 5040 24 CO cH Ex
84. FID CNT CNT 3 CNT 1 CNT C OEL CNT CNT OEL 0 03 mg m 30 ugm 2 4 4 um 50 OBL
85. a 227 A CNT 5 10 94 137 SOD ICAM 14 i p fen ijg CNT Wistar REF yv F 0 2 0 4 mg CNT
86. CNT H in vitro CNT SHE E BSA 1 H CNT in vitro 9 CNT in vitro 8 SG CNT v
87. 3 A WPMN TASC SG CNT MDCK 2014 6 WPMN 2015 2 WPMN 2 ISO ISO ISO TC229 WG3 ISO TC229 JWG2 2012 11 1
88. NEDO D BASE NIOSH WS lt 1 NEDO NEDO S ES MWCNTN MWCNTON CNT gt CNT CNT MWCNT N 4 NOAEL 0 37 mg m CHD DOM ATO NOAEL 1 8 5 13 0 08 mg m CNT MWCNT N
89. Quantification of nano object release from powders by generation of aerosols First edition 439 5 ADME Absorption Distribution Metabolism amp Excretion APS Aerodynamic Particle Sizer BALF Bronchoalveolar Lavage Fluid BCF Bioconcentration Factor BET Brunauer Emmett Teller BMCL Benchmark dose lower confidence limit BMD NOAEL BMD Benchmark dose BOD Biochemical Oxygen Demand BSA Bovine serum albumin BW Body Weight CAS No Chemical Abstracts Service Number
90. PC MED enr eM M ED sass oe 25 D 26 2 26 A MIRA IHR IIRIHI RIRRMRHmM IIR 26 B liQ 27 TASC EE 28 1 28 2 28 1 ee 28 2 28 3 30 1 31 2 e MH 31 4 meme 32 1 OECD cece cece MMMMMMMMMMMMMM Seeee 32 2 ISO f MMMMMMMMMMMReeeeM MMMMeee 33 LHR meth III MM 34 38 1
91. P10024 ff eDIPS eDIPS CNT TASC 3 2015 3 CNT TASC NEDO PLT A 2011 8 H i My R P06041 1 8 AORC 15 10 D d
92. 26 6 7 cNT 100 cn 30cm Yn 6 D Ide Hse 2500 rpm 7 BERR CK AGAT LS Ae B SG CNT CNT CNT CNT
93. 5 1 24 48 72hr 1 mL S IQ M ONE ma 1 FOR fu e OECD TG405 x ed IR 0 5 Olive oil MSG eB HE E 0 5g 1 24 48 72hr OECD TG404 m Olive oil d ii CNT Hartley 24 72 0 4 g OECD TG406 Ge it a m 247 CNT ETILE Yy ERR L Buehler EI EA KIS REE 12 CNT EAE LE gee AE 24 2hr DG CALE orep Taide
94. a CNT gt Parks 20 2 A a Pseudokirchneriella subcapitata 72 RRR 1 10 mg L BEC 13 Ampelisca abdita CNT SG65 SouthWest Nano Technologies 7 Americamysis bahia CNT CNT OECD TG201 GLP 3 9 44 50 ECs gt 10 mg L NOEC 0 32 mg L Tes 4 CNT
95. 100 DNA 40 eDIPS ceDIPS CNT TASC 2014 3 31 2 2014 11 28 3 2015 3 27 CNT TASC T 305 8565 1 1 1 s T 305 8569 16 1 eDIPS CNT ROMA CWAY ADE f
96. Occupational risk management applied to engineered nanomaterials Part 2 Use of the control banding approach Shvedova AA Yanamala N Kisin ER Tkach AV Murray AR Hubbs A Chirila MM Keohavong P Sycheva LP Kagan VE Castranova V 2014 Long term effects of carbon containing engineered nanomaterials and asbestos in the lung one year postexposure comparisons Am J Physiol Lung Cell Mol Physiol 306 2 L170 182 International Agency for Research on Cancer Volume 111 2014 Fluoro edenite silicon carbide fibres and whiskers and single walled and multi walled carbon nanotubes IARC Working Group Lyon 30 Sep 7 Oct 2014 IARC Monogr Eval Carcinog Risk Chem Hum in press Yann G Dana L Kathryn ZG B atrice L S Fatiha El G V ronique B Lamia B T Neela G Chiara S Heidi M Kurt S 2014 Carcinogenicity of fluoro edenite silicon carbide fibres and whiskers and carbon nanotubes The Lancet Oncology 15 13 1427 1428 Donaldson K Murphy FA Duffin R Poland CA 2010 Asbestos carbon nanotubes and the pleural mesothelium a review of the hypothesis regarding the role of long fibre retention in the parietal pleura inflammation and mesothelioma Part Fibre Toxicol 7 5 Murphy FA Poland CA Duffin R Al Jamal KT Ali Boucetta H Nunes A Byrne E Prina Mello A Volkov Y Li S Mather SJ Bianco A Prato M Macnee W Wallace WA Kostarelos K Donaldson K 2011 Length dependent retention of carbon nanotubes in the pleural space of
97. Kotake M Shigeta M Uejima M Saito K Hashimoto N Kishimoto A 2013 Potential release of carbon nanotubes from their composites during grinding J Phys Conf Ser 429 012049 Saito T Ohshima S Okazaki T Ohmori S Yumura M Iijima M 2008 Selective diameter control of single walled carbon nanotubes in the gas phase synthesis J Nanosci Nanotech 8 11 6153 6157 Nagai H Okazaki Y Chew SH Misawa N Yamashita Y Akatsuka S Ishihara T Yamashita K Yoshikawa Y Yasui H Jiang L Ohara H Takahashi T Ichihara G Kostarelos K Miyata Y Shinohara H Toyokuniet S 2011 Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis Proc Natl Acad Sci USA 108 E1330 1338 Sakamoto Y Nakae D Fukumori N Tayama K Maekawa A Imai K Hirose A Nishimura T Ohashi N Ogata A 2009 Induction of mesothelioma by a single intrascrotal administration of multi wall carbon nanotube in intact male Fischer 344 rats J Toxicol Sci 34 65 76 Takagi A Hirose A Futakuchi M Tsuda H Kanno J 2012 Dose dependent mesothelioma induction by intraperitoneal administration of multi wall carbon nanotubes in p53 heterozygous mice Cancer Sci 103 1440 1444 Sargent LM Porter DW Staska LM Hubbs AF Lowry DT Battelli L Siegrist KJ Kashon ML Mercer RR Bauer AK Chen BT Salisbury JL Frazer D McKinney W Andrew M Tsuruoka S Endo M Fluharty KL Castranova V Reynolds SH 2014 Promotion of lu
98. NOAEL 0 05 mg m OEL NOAEL 4 5 0 0025 mg m 2 2 25 4 NIOSH gt i CNT NIOSH BMD LZ GE OC it A ARES HLS Pauluhn Ma Hock l BMD 10 95 0 00019 0 0019 mg m los NIOSH mg m 8
99. OELy E AF retained dose AF deposited dose AF kinetics AF AM volume Qr Qu DFs DFr AMvolp AMvolu AF retained dose AF ti x inetics AFAM volume z mi AF kinetics Qr DFR AMyoum AMyoin 0 14 m day kg 0 118 T 10 0 29 m day kg 0 057 5 x 101 8 7 x 1019 1x ME is 2 ae S 0 05 mg m mg m CNT HAD Co SEED toa EB H tzr 60 1 10 1 m7day kg Qr IX Mauderly D 0 8L kg 25D
100. Review of Health and Environmental Safety ENRHES Project Final Report 2010 http ihcp jrc ec europa eu whats new enhres final report TASC 2013 NEDO P10024 lt http www aist riss jp assessment gt Hashimoto N Ogura I Kotake M Kishimoto A Honda K 2013 Evaluating the capabilities of portable black carbon monitors and photometers for measuring airborne carbon nanotubes J Nanopart Res 15 2033 Ogura I Kotake M Hashimoto N Gotoh K Kishimoto A 2013 Release characteristics of single wall carbon nanotubes during manufacturing and handling J Phys Conf Ser 429 012057 2011 2011 8 12 NEDO P06041 http www aist riss jp assessmen 7 gt NIOSH 2012 General Safe Practices for Working with Engineered Nanomaterials in Research Laboratories DHHS NIOSH Publication No 2012 147 May 2012 NIOSH 2013 Current Strategies for Engineering Controls in Nanomaterial Production and Downstream Handling Processes DHHS NIOSH Publication No 2014 102 Nov
101. 0 32x HS r 0 75 20 0 20 40 60 80 100 ug m3 M5 SG CNT 3 A C c OPC B C a b CNT CNT
102. Tt 24 0 3 CMC EE m VELA rad 3 hr 0 2 1 0 mg kg dad z Hja 1 Tween80 saylan PBS keg E Mr nS Crl CD SD Tail DNA fifi L hf 1 1 0 04 0 2mgkg 3 hr 1 Tween80 Tall DNA li PBS RUK g YA CNT 24 lt gt Shvedova 2014 CNT Unidym 40 ug 5 mg m CNT 3 4 pg 1 9 NS A Big CNT
103. 0 8 X 10 Xx 60X 10 X 6hr FREE 20 29 mday kg Q 1 10 m 70kg UT 10 70 0 14 m day kg CNT Anjilvel amp Asgharian DF 0 057 DEi 0 118 Oberdorster Krombach 5 gt AMvols 8 7X10 AMvoli 5X10 um7kg body weight 320g 70kg lt 3 BASF Nanocyl NC7000 gt BASF 235 Nanocyl NC7000 Nanocy1 NC7000 LOAELr 0 1 mg m 2 CNT Nanocyl NC7000 9 1 90 H HWA aR ie S 20
104. 2013 TASC 2013 NEDO P10024 lt http www aist riss jp assessment gt Horie M Stowe M Tabei M Kato H Nakamura A Endoh S Morimoto Y Fujita K 2013 Dispersant affects the cellular influences of single wall carbon nanotube the role of CNT as carrier of dispersants Toxicol Mech Methods 23 5 315 322 Fujita K Fukuda M Endoh S Kato H Maru J Nakamura A Uchino K Shinohara N Obara S Nagano R Horie M Kinugasa S Hashimoto H Kishimoto A 2013 Physical properties of single wall carbon nanotubes in cell culture and their dispersal due to alveolar epithelial cell response Toxicol Mech Methods 23 8 598 609 ERES Q013 5 817777 72u VDE International Organization for Standardization 2012 Technical Specification ISO TS 12025 Nanomaterials
105. Super Growth Scanning Mobility Particle Sizer Superoxide dismutase Technology Research Association for Single Wall Carbon Nanotubes Transmission Electron Microscope Test Guideline Thermo Gravimetry Analyzer Time weighted average Ultra Violet WG3 of ISO TC229 Health Safety and Environment USA convenor Working Party on Manufactured Nanomaterials yo 9000Xg MSDS Material Safety Data Sheet CNT pus lus 3E 2s NX x q N ISO TC229 OECD DNA DNA DNA DNA
106. anotubes following inhalation and intratracheal instillation Nanotoxicology 6 6 587 599 48 Pauluhn J 2010 Subchronic 13 week inhalation exposure of rats to multiwalled carbon nanotubes toxic effects are determined by density of agglomerate structures not fibrillar structures Toxicol Sci 113 1 226 242 49 Mauderly J L 1986 Respiration of F344 rats in nose only inhalation exposure tubes J Appl Toxicol 6 1 25 30 50 Anjilvel S Asgharian B 1995 A multiple path model of particle deposition in the rat lung Fundam Appl Toxicol 28 1 41 50 51 Oberd rster G 1995 Lung particle overload Implications for occupational exposures to particles Regul Toxicol Pharmacol 27 1 123 135 52 Krombach F M nzing S Allmeling A M Gerlach JT Behr J D rger M 1997 Cell size of alveolar macrophages an interspecies comparison Environ Health Perspect 105 Suppl 5 1261 1263 53 Ma Hock L Treumann S Strauss V Brill S Luizi F Mertler M Wiench K Gamer AO van Ravenzwaay B Landsiedel R 2009 Inhalation toxicity of multiwall carbon nanotubes in rats exposed for 3 months Toxicol Sci 112 2 468 481 36 54 55 56 57 58 59 60 61 62 63 64 65 66 66 lt https staff aist go jp kishimoto atsuo NIOSH CIB65_text_JPN_ pdf gt Engineered Nanoparticles
107. e M Oyabu T Myojo T Hashiba M Mizuguchi Y Kambara T Lee BW Kuroda E Shimada M Wang WN Mizuno K Yamamoto K Fujita K Nakanishi J 2012 Pulmonary toxicity of well dispersed single wall carbon nanotubes after inhalation Nanotoxicology 6 7 766 775 42 Bide RW Armour SJ Yee E 2000 Allometric respiration body mass data for animals to be used for estimates of inhalation toxicity to young adult humans J Appl Toxicol 20 273 290 43 ICRP 1994 Human respiratory tract model for radiological protection In Smith H ed Annals of the ICRP Tarrytown New York Internation Commission on Radiological Protection ICRP Publication No 66 44 Pauluhn J 2010 Multi walled carbon nanotubes Baytubes approach for derivation of occupational exposure limit Regul Toxicol Pharmacol 57 1 78 89 45 Luizi F 2009 Responsible Care and Nanomaterials Case Study Nanocyl European Responsible Care Conference Prague 21 23 Oct 2009 lt http www cefic org Documents ResponsibleCare 04_Nanocyl pdf gt 46 NIOSH 2013 NIOSH Current Intelligence Bulletin 65 Occupational Exposure to Carbon Nanotubes and Nanofibers April 2013 47 Morimoto Y Hirohashi M Ogami A Oyabu T Myojo T Todoroki M Yamamoto M Hashiba M Mizuguchi Y Lee BW Kuroda E Shimada M Wang WN Yamamoto K Fujita K Endoh S Uchida K Kobayashi N Mizuno K Inada M Tao H Nakazato T Nakanishi J Tanaka 1 2012 Pulmonary toxicity of well dispersed multi wall carbon n
108. gy Development Organization National Institute of Occupational Safety and Health No Observed Adverse Effect Level No Observed Effect Concentration Organisation for Economic Co operation and Development Occupational Exposure Limit 8 hydroxy 2 deoxyguanosine 39 40 1 1B ISO 229 ISO TS 12025 4
109. imoto Y Ogami A Iwahashi H 2014 Intratracheal instillation of single wall carbon nanotubes in the rat lung induces time dependent changes in gene expression Nanotoxicology 9 1 12 Pietroiusti A Massimiani M Fenoglio I Colonna M Valentini F Palleschi G Camaioni A Magrini A Siracusa G Bergamaschi A Sgambato A Campagnolo L 2011 Low doses of pristine and oxidized single wall carbon nanotubes affect mammalian embryonic development ACS Nano 5 6 4624 4633 35 37 Fujitani T Ohyama K Hirase A Nishimura T Nakae D Ogata A 2012 Teratogenicity of multi wall carbon nanotube MWCNT in ICR mice J Toxicol Sci 37 1 81 89 38 Roman D Yasmeen A Mireuta M Stiharu I Al Moustafa AE 2013 Significant toxic role for single walled carbon nanotubes during normal embryogenesis Nanomedicine NBM 9 945 950 39 Ema M Imamura T Suzuki H Kobayashi N Naya M Nakanishi J 2013 Genotoxicity evaluation for single walled carbon nanotubes in a battery of in vitro and in vivo assays J Appl Toxicol 33 933 939 40 Naya M Kobayashi N Endoh S Maru J Honda K Ema M Tanaka J Fukumuro M Hasegawa K Nakajima M Hayashi M Nakanishi J 2012 In vivo genotoxicity study of single wall carbon nanotubes using comet assay following intratracheal instillation in rats Regul Toxicol Pharmacol 64 1 124 129 41 Morimoto Y Hirohashi M Kobayashi N Ogami A Hori
110. mice initiates sustained inflammation and progressive fibrosis on the parietal pleura Am J Pathol 178 6 2587 2600 Nagai H Okazaki Y Chew SH Misawa N Yamashita Y Akatsuka S Ishihara T Yamashita K Yoshikawa Y Yasui H Jiang L Ohara H Takahashi T Ichihara G Kostarelos K Miyata Y Shinohara H Toyokuni S 2011 Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis Proc Natl Acad Sci U S A 108 49 E1330 1338 Nagai H Toyokuni S 2012 Differences and similarities between carbon nanotubes and asbestos fibers during mesothelial carcinogenesis Shedding light on fiber entry mechanism Cancer Sci 103 8 1378 1390 Finnish Institute of Occupational Health 2013 Evaluation of the health effects of carbon nanotubes lt http www tsr fi c document_library get_file folderld 13109 amp name DLFE 9367 pdf gt Matsumoto M Serizawa H Sunaga M Kato H Takahashi M Hirata Koizumi M Ono A Kamata E Hirose A 2012 No toxicological effects on acute and repeated oral gavage doses of single wall or multi wall carbon nanotube in rats J Toxicol Sci 37 3 463 474 Ema M Matsuda A Kobayashi N Naya M Nakanishi J 2011 Evaluation of dermal and eye irritation and 4 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 skin sensitization due to carbon nanotubes Regul Toxicol Pharmacol 61 3 276 281 Ogura I
111. n E 28 5 1 JV LTSR HQ gt 1 C inar pou CNT Y fiti peek amp BJS CNT mg m Ed cp PAAR Be ihe BE OEL amp ea DAY FL 28 E zm H HO 1 HQEI OAA Xu
112. n 2 Cu 0 010 mg g Ni 0 009 mg g Pb 0 006 mg g 4 2009 3 2009 7 2009 3 H 2009 3
113. ng adenocarcinoma following inhalation exposure to multi walled carbon nanotubes Part Fibre Toxicol 11 3 TASC 2011 15618 2011 15606 TASC 2011 15619 TASC 2011 45620 Parks AN Portis LM Schierz PA Washburn KM Perron MM Burgess RM Ho KT Chandler GT Ferguson PL 2013 Bioaccumulation and toxicity of single walled carbon nanotubes to benthic organisms at the base of the marine food chain Environ Toxicol Chem 32 6 1270 7 2011 95401 2011 95402 TASC 2011 A100699 2011 95403 TASC 2011 A100698 TASC 2011 A100700 2011 95400 Liou SH Tsou TC Wang SL Li LA Chiang HC Li WF Lin PP Lai CH Lee HL Lin MH Hsu JH Chen CR Shih TS Liao HY Chung UT 2012 Epidemiological study of health hazards among workers handling engineered nanomaterials J Nanopart Res 14 8 878 892 Fujita K Fukuda M Fukui H Horie M Endoh S Uchida K Shichiri M Mor
114. t SicHasdey ee SOR OE ee Buehler 1 2 TER g 0 2 g L i 4 o e CNT gt Pietroiusti 2011 CNT Cheap Tubes Imc p SWCNT o SWCNT uo SWCNT CD1 100 ns Fujitani 2012 CNT 2 mg kg 4 mg kg Roman 2013 tk X KY ARIZ 25 ug ZEON 3 A i Eat n fiet OECD TG471 ij OA v FESZ SN HEIN 12
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