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1. R CaD 1 NT proBNP proBNP 1 35 1 12 5 55 pg mL n 67 40 59 77 pg mL n 84 121 pg mL n 188 60 88 131 pg mL n 75 165 pg mL n 127 2 125 pg mL2. c 2D NT proBNP proBNP 24 L Ca
3. 4 2 ER A 1 SE 2 4 2 15 000 pg mL BNP 108 proBNP 32 BNP BNP 32 76 NT proBNP 1 76 BNP 32 proBNP NT proBNP 1 76 BNP 32 proBNP NT proBNP 1 76 9 BNP 32
4. ul 1 2 b 3 1 1 5 IL L Cal 1 1 1 L Cal 1 1 1 1
5. Water bath 3 p 6 7 8 9 10 15 25C
6. E 1 2 3 4 E NT proBNP 50 200 pg mL Counts E N NT proBNP 1 000 4 000 pg mL 15 000 200 000 Counts 50 1 000 pg mL 2 000 8 000 pg mL 20 50 1 000 pg mL 2 000 8 000 3 10 5 35 000 pg mL N 1 000 14 000 pg mL CV 2
7. 2010 2010 NT proBNP 2010 1 4 4 M M M M M PC CC M 1 proBNP a
8. 3 1 2 3 1 1 2 proBNP 2 8C 15 25 C 2 1 proBNP 2 Exp 2
9. 35 mg dL 4 000 mg dL 1 2 1 500 IU mL 2 3 30 ng mL 1 3 5 mg 8 DE RR RUUUOUGDBNR RSE
10. 87 r 0 94 roBNP 3 4 3 1 2 y 7 64 x 34 09 y x BNP 32 C 2 BNP 32 BNP 32 proBNP NT proBNP 1 76 2 NT proBNP 1 76 NT proBNP 1 76 proBNP 2 56
11. 1 1 NT proBNP 2 Ru bpy NT proBNP 2 MP SA MP SA MP Ru bpy NT proBNP B F SA MP Ru bpy NT proBNP Ru bpy NT proBNP 2010 iin 1 MP G30 gL 37 9 2 mL 620 nm
12. BNP BNP proBNP N BNP 1 108 proBNP BNP BNP 32 77 108 proBNP BNP 1 P1 76 NT NT proB
13. BCLIA 1 1 NT proBNP 2 Ru bpy NT roBNP 2 MP SA MP M 5 3 2010 e 411 e 601 SA MP NoBNR pFoBNP yy Rubpy NT roBNP B F SA MP Ru bpy NT proBNP Ru bpy
14. BNP BNP B atriuretic Peptide 32 P ANP BNP Brain Atrial Natriuretic Peptide
15. r 0 999 y 1 05 x 53 92 y x NT proBNP 1 76 1 2 3 5 6 1 2 3 5
16. NT proBNP x 2 R2 1 2 2 II NT proBNP 2 Ru bpy NT proBNP 1 proBNP 2 2 8C 2 8C 12 8 1 2 2 15 25 N NT proBNP i 4 4 NT proBNP
17. 2 Exp NT proBNP proBNP 100 MP W 1X6 5 mL 1 R1 1x9 mL 2 R2 1x9 mL NT proBNP proBNP 5x100 M P M 1X6 5 mLX5 1 R1 1xX9 mLX5 2 R2 1xX9 mLX5 6x380 mL 6 X380 mL M 1x2L 2x2L 2010 e 411 1X2L 2X2L e 601 M K 1 Gary F Blackburn et al Electrochemiluminescence Detection 2 for Development of Immunoassays and DNA Probe Assays for Clinical Diagnostics Clin Chem 37 1991 p 1 534 p 1 539 Yoshihiko Seino et al Application of NT proBNP and BNP measurements in cardiac care a more discerning marker for the detection and evaluation of heart failure The European Journal of Heart Failure 6 2004 p 295 p 300
18. 1 000 ppm 0 1 HIV HBV HCV 121 20 1 000 ppm 0 1 1
19. 105 0014 2 6 1 0120 600 152 COBAS is trademark of Roche Roche 0 3639614 001 DG
20. gt CODaS 2008 4 4 a 87 744 2007 6 3 NO 21800AMY10115000 2 8 C 3 NT proBNP 20 12 1 N proBNP 2 1 1 4 g dL
21. 4 4 3 5 6 7 9 M A Barjas et al DIAGNOSIS SYMPTOMS 223 How can the ro B Natriuretic Peptide NT proBNP be optimised in heart failure screening A prospective observational of Heart Failure role of N terminal European Journal o 1 2004 p 51 The Impact of Cardiac Na Determination on the Diagnosis and Management of Heart Failure Clin Chem Lab Med 39 7 2001 p 571 p 588 BNP p 13 p 24 Sudoh T et al A new natriuretic peptide in porcine brain Nature 332 1988 p 78 p 81 comparative study Supplements Vol 3 Johannes Mair et al riuretic Peptide Sudoh T et al A new member of natriuretic peptide familiy identified in porcine braim Biochem Biophys Res Commun 168 1990 p 863 p 870 N proBNP NT proBNP BIO Clinica 19 6 2004 p 47 p 53 T 105 0014 2 6 1 0120 600 152
22. 5 in vitro 4 1 proBNP 6 MP M 3 SA MP 2010 e 411 1R1 e 601 NT proBNP
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