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1. DNA 13 DNA 30C 9 4C 90 30C 14 30C 9 4C 30 30C 8 2 2 30 14 Amplification error Tndistinct differentia1 curvel2. DNA gt 1 DNA i densy Check CYP2C19 2 3 i densy Check DNA 10 30 3 EDTA
3. gt 1 DNA 2 DNA 3 4 gt EDTA
4. 10 1 10 1 22 1 l Shinya K et al Nucleic Acids Research 29 34 2001 2 S M De Morais et al Mol Pharmacol 46 594 1994 3 Takahisa Furuta et al Drug Metab Pharmacokinet 20 153 2005 1480 TEL 0120 103 400 8 30 18 00 8 30 12 00 1480 df 57 CP76131 004
5. 14 DNA DNA DNA lt gt 1 RI R2 R3 R4 R5 R6 AR1 B R2 wm WWWUUUUW N C R3 ONA A B C CE P 6 B Q F R4 H aE i G R5 I H R6 2 3 i lt R2 CYP2C19 2 a CYP2C19 2 CYP2C19 2 CYP2C19 3 CYP2C19 3 CYP2C19 3 R3 DNA DNA CYP2C19 I CYP2C19 3 CYP2C19
6. IS 5320 DNA CYP2C19 2 3 1 DNA DNA 2 PCR CYP2C19 2 3 DNA 2 DNA DNA DNA CYP2C19 2 3 PDNA 3 Tm QP DNA CYP2C19 2 3 00 0 Ui fm
7. lt gt 10 30 lt gt gt 1 10 30 2 i densy Check I CYP2C19 2 3 i densy Check I CYP2C19 2 3 10 30 i densy Check I CYP2C19 2 3 i densy Check II CYP2C19 2 3 3 4
8. CYP2C19 2 3 CYP2C19 2 A CYP2C19 3 A QP Quenching Probe 2 i densy Check CYP2C19 2 3 IS 5320
9. DNA gt 1 2 3 10 30C ss 1 r 12 ee DNA DNA 4 5 6
10. 22400AMX01410000 P450 CYP 2012 10 1 CYP2C19 2 3 ON CM RMN i densy Check CYP2C19 2 3 RE NO
11. IS 5320 1 2 70 L 3 4 1 4 pL DNA 2 3 4 1 1 densy Check I CYP2C19 2 3 i densy CheckII CYP2C19 2 3 2 i densy Check I CYP2C19 2 3 1
12. 2 3 4 lt gt co 1 2 8 2 3 RN
13. 3 G A 8 3 3 GC A 3 A A 9 3 3 A A 2 2 G G DNA 3 2 G G 4 3 G G DNA 5 3 G G 6 2 G A DNA 7 2 A A DNA 8 3 G A DNA 9 3 A A DNA 2 1 CYP2C19 2 100 109 109 2 CYP2C19 3 CYP2C19 3 3008 A 0 seee200PMko Pe 109 100 109 109 3 0 00067 amo1 L DNA 4 DNA gt 2 RI
14. 2 G A 6 2 G A 2 A A 7 2 A A lt CYP2C19 3 gt 3 G G 4 3 G G 3 G A 8 3 G A 3 A A 9 3 A A lt CYP2C19 2 gt 2 G G 2 3 2 G G 2 G A 6 3 2 G A 2 A A 7 3 2 A A lt CYP2C19 3 gt 3 G G 4 3 3 G G
15. gt 1 2 3 121C 20 0 1 5 PP PP PP 1 2 lt 8C 2 9
16. 6 Tm CYP2C19 CYP2C19 2 CYP2C19 3 CYP2C19 9 1 CYP2C19 2 gt 2 G G 2 2 G G 2 G G 3 2 G G lt CYP2C19 3 gt 3 G 6 34 3 G G 3 G G 5 3 G G lt CYP2C19 2 gt 2 G G 2 2 G G
17. 4 DNA DNA QIAamp DNA Mini Kit 1 10 ng L A260 A280 1 7 1 9 DNA 5 3 000 10 000 L ON 7 8 9 10716 10
18. nm Tm Tm 50C CYP2C19 3 GC 6 Tm 50 59C CYP2C19 3 G A Tm 59C CYP2C19 3 A A 2 AA A 6 G 1 Undefined Type 2 CYP2C19 2 Exon 5 681 G gt A CYP2C19 3 Exon 4 636 G gt A 3 4 i densy Check CYP2C19 2 3 Check meas errorl 5 CYP2C19 1 1 1 2 1 3 Extensive Metabolizer 2 3 2 2 3 3 Poor Metabolizer
19. 2 70 kL i densy Check I CYP2C19 2 3 3 4 i densy Check IL CYP2C19 2 3 1 3 4 1 1 Tm 420 485 nm 520 555 nm Tm Tm 51C CYP2C19 2 GC G Tm 51C 59C CYP2C19 2 G A Tm 59C CYP2C19 2 A A 520 555 nm 585 700
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