TDM カルバマゼピン - 積水メディカル株式会社
Contents
1. 1 1 2 3 4 2 1 EDTA2. CBZ CBZ 5H b f 5 70 10 11 10 11
3. 15 30 C 7 2 8C 3 20 20mg dL 20mg dL 500mg dL 50mg dL 2500 5 450U 2
4. 2 CBZ CBZ 2 1 2 3 4 5 3 1
5. 2 1 1 07g mL 1 0 090 0 230 2 0g mL 27g mL 1 50 85 2 80 120 3 10 1 3 4 7170S 0 4 20 ug mL 5 1 N 66 r 0 992 y 0 93x 0 25 2 N 76 r 0 991 y 0 97x 0 29 6 1 1 HIV HBV HCV
6. 01 1 121C 20 01 CBZ CBZ to Cw 5 4 LMS 2
7. 1 CBZ CBZ CBZ 2 37C 37C 2L 220L 270 60zL 70 I 37C 247 TI TI 600nm TDM 1 4 12g mL2 9 6 12xg mL
8. 3 g mL 100 6 1000 005 2 10 11 25 316 2000 015 2000 007 250 02 1000 0 1000 006 1000 0 2000 001 nt L000 Or 200 15 3000 003 5000 002 50 242 200 02 1000 002 400 0 1000 001 500 0 1500 002 2000 0 02 7000 0 01 3 1 TDM 2
9. 10 11 15 48 8 gt 60 5 8 10 11 9 1 2 1 2 3
10. 14 2 8C TDM CBZ 44mLx 1 CBZ 12mLx1 1 Morselli P C Carbamazepine absorption distribution and excretion in complex partial seizures and their treat ment Advances in Neurology Vol II edited by Penry J K Daly D D New York Raven Press pp 279 393 1975 Larkin J G Herrick A L McGuire G M Percy Robb LL W Brodie M Antepileptic Drug Monitoring at the Epilepsy Clinic A Prospective Evaluation Epilepsia 32 89 95 1991 Altafullah I Talwar D Loewenson R Olson K Lockman L A Factors Influencmg Serum Levels of Carbamazepine 2 3 and Carbamazepine 10 11 epoxide in children PEpilepsy Res 4 72 80 1989 Mackichan J J Kutt H Carbamazepine Therapeutic use and serum concentration monitoring In Taylor WJ Finn A L eds Individualizing Drug Therapy Practical Applications of Drug Monitoring Gross Townsend Frank Inc New York 2 1 25 1981 Baselt RC Carbamazepine im Disposition of Toxic 1 Drugs and Chemicals in Man C
11. 200110 005 13A2X00197218102 2012 2 5 2008 5 4 30395000 TDM i 2
12. hemical Toxicology Institute Forster City California 5th Edition 126 129 2000 6 Warner A Privitera M and Bates D Standards of labo ratory Dractice antiepileptic drug monitoring Clin Chem 44 5 1085 1095 1998 7 51 1 131 141 2004 8 0120 249 977 FAX 0120 247 477 ass 13 5
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