TDM バルプロ酸
Contents
1.2. 37C 2uL 150zL 270 37C 50zL 53 1 37C 107 T I 600nm TDM 1 2 50 100 g mL 3 9 100g mL 9
3. 1 O0ug mL 1 0 15 0 30 2 0g mL 125 ug mL 1 75 95 2 80 120 3 10 1 3 4 7170S 12 150 ug mL 5 1 N 66 r 0998 y 1 08x 029 2 N 101 r 0994 104x 277 6 1 2 1 HIV HBV HCV
4. 1 2 1 2 3
5. 2 VPA VPA 2 1 3 4 5 3 1 2 3 4 4 0 1 1
6. 6 VPA VPA 2
7. 3 450U _ 2 g mL 2 2 1000 05 2 500 10 6 1000 0 5 10 11 1000 0 6 1000 05 2000 0 3 2000 0 400 1 1000 02 1000 0 6 3 1 TDM 2 1 VPA VPA VPA
8. 1 6 0120 249 977 FAX 0120 247 477 assmm 13 5
9. 2 90
10. 1 1 EDTA 15 30 C 7 2 8C 4 20 3 7 to 4 2 1 20mg dL 20mg dL 500mg dL 50mg dL 2500 5 2
11. 121 20 0 1 VPA VPA 1 2 8C 2 20
12. TDM VPA 30mLx1 VPA 10mLx1 x 1 Wilder B J Rangel R J Review of valproate monother sy apy in the treatment of generalized tonic clonic seizures Am Med 84 Suppl 1A 7 13 1988 Chadwick D W Valproate monotherapy in the manage ment of generalized and partial seizures Ppilepsia 28 Supplement 2 S12 S17 1987 Schobben F van der Kleijn E Gabreels F J M Pharmacokinetics of di N propylacetate in epileptic patients Europ J Clin Pharmacol 8 97 105 1975 4 Cloyd C Leppik I E Valproic acid therapeutic use and serum concentration monitoring in Individualizing Drug Therapy Practical Applications of Drug Monitoring Vol 2 Taylor W Finn A L eds New York Gross Townsend Frank Inc pp 87 108 1981 Klotz U Schweizer C Valproic acid in childhood epilep sy Anticonvulsive eficacy in relation to its plasma lev els Int J Clin Pharmacol Ther Toxicol 18 461 465 1980 Tumbull D M Rawlins M D Weishtman D Chadwick D W Plasma concentrations of sodium valproate Their clinical value Ann Neurol 14 38 42 1983 7 51 1 131 141 2004 8
13. 200165 005 13A2X00197218107 2014 3 5 2012 2 4 30404000 TDM 1 2 3 4 5
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