請求項1 - Questel
Contents
1. 16 JP 5187642 B2 2013 4 24 C2. N m st HOO 9 L3 OO HOO TH 52 3 O O O O 15 JP 5187642 B2 2013 4 24 U 10000000000000000 10000000000000000 0000
3. 10000000 HHHHHHHHHHH C IHU 5 5 00000 10000000000 USB DG sp 0000 100000 5 5 C 0000 0 0 0 HIHHHHHHHHHH HHHHHHHHHHH 5 5 5 5 10 20 30 40 50 JP 5187642 B2 2013 4 24 21 100000000 100000000 1000 1000 1000000000000 100000000 1000000000 10 cfu OD IgA 0 18 0 015 M 0 16 0 013 0 20 0 014
4. 10 20 30 40 50 9 JP 5187642 B2 2013 4 24 10 20 30 40 50 10 JP 5187642 B2 2013 4 24 n tu EE Ri H 100000000 el 2 ee 20
5. HH HHHHHHHHHHHHHHHHHHHHHHHHHHHHH 10 1 4 10 cfu 1 2 7 25 01620012 040 0145 1 7 7 3 0140014 1 7 5 25 00540011 01240038 2 7 5 32 00620010 0140041 3 5 s 640010 0130028 5 25 00440012 omaoo 5 12 00240008 0100098 5 00240 0 02 0 006 0 14 0 032 EXA BALB c 1 lgA E 01550012 0420133 32 0 13 0 014 0 39 0 140 0 130 038 5 33
6. 10 20 30 40 50 13 JP 5187642 B2 2013 4 24 C C m 10 20 30 40 50 JP 5187642 B2 2013 4 24 14
7. 10 20 30 40 50 17 JP 5187642 B2 2013 4 24 5 5 5 5 10000000000 10000000000 HHHHHHHHHHH 5 5 00000 PHU 5 5 5 00000 HHHHHHHHHHH HHHHHHHHH 5 5 5 5 5 DOLO 00000000 00 10 20 30 40 50 18 JP 5187642 B2 2013 4 24
8. 6 JP 5187642 B2 2013 4 24 10 20 30 40 50 7 JP 5187642 B2 2013 4 24 10 20 30 40 50 8 JP 5187642 B2 2013 4 24
9. 40 11 JP 5187642 B2 2013 4 24 C n C H o C S C 3 C C xe 10 20 30 40 50 12 JP 5187642 B2 2013 4 24 C non C E C
10. 26 JP 5187642 B2 2013 4 24 0000000000 0000 3004 20060 1000 3vo4 72 72 72000 00 0 72 00000000000 000000 0 72 100 100 60000 00000 000000000000 10000000 J Gre Md 8 10 1341 6 LANET Vol 338 8774 p 1055 9 nd Vol 17 2 27 50000000 re d 39 00 39 395 9 00 972 47 00 47 48 CN NE EMBASE S STN J STH us J us J ST7580 Dr earl
11. JP 5187642 B2 2013 4 24 19 JP 24 FF B2 11 5187642 P5187642 45 25 4 24 2013 4 24 24 25 2 1 2013 2 1 51 Int Cl FI A61K 39 02 2006 01 A61K 39 02 ZNA A61K 39 112 2006 01 AGIK 39 112 A61K 39 106 2006 01 AGIK 39 106 A61K 35 7 2006 01 AGIK 35 74 A A61K 9 48 2006 01 A61K 9 48 18 426 E 21 2009 505269 P2009 505269 73 000191755 86 22 20 3 19 2008 3 19 86 PCT JP2008 055815 2 40 87 W02008 114889 73 504150450 87 20 9 25 2008 9 25 ZEBRA 22 10 25 2010 10 25 1 1 31
12. 2007 70626 P2007 70626 74 100163647 32 19 3 19 2007 3 19 ER 33 JP 72 1 1 72 1 1 54 5700000000 00000000000 100000000000000000000 00000000 O 1000000000000000000 HHHHHHH 10 100000000000000000000000000000000 20000 0 00000000000000000000 000 0000000000000000000000000000000000000000 0000000000 0000000000 0000000 000000000000 00000 000000000 0 0 0 1000 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH 20
13. a 5 28 0030012 01220032 5 19 5187642 2 2013 4 24 2 IgA 0 13 0 013 0 41 0 142 0 05 0 011 0 130 038 0 06 0 010 0 12 0 052 0 06 0 010 0 110 028 0 02 0 008 0 10 0 022 0 02 0 006 0 15 0 033 10 cfu OD OD 0130012 038 0142 0120013 027 0153 4 0130014 9 NE 0 06 2 0 010 0 11 20 028 003 0006 0 142 0 031 0 060 011 0 11 0 038 0 05 0 010 0 12 0 051 4 4 10 1 0 03 0 008 0 13 0 036 0 02 0 012 0 110 038 10 20 30 40 50 20 JP 5187642 B2 2013 4 24
14. 2 JP 5187642 B2 2013 4 24 1000000 10000000000 100000 10000000000 100000 0 10000000000 10000000000 10000000000 0 0 1000000 10000000000 100000
15. 0 04 0 011 lgA OD RRIT 7 3 7 10 11 12 20 3131819 2 26 8 9 Hi TION c gt eojojojo 2 35 5 eoror oj o Hi HY Hy lt L cN ajajaja u e 100 1000000000000 1000 100000 30 100 10000000000 10000 100000 100 HHHHHHHHHH HHHHHHHHHHHHHHHH 0000000000000000000000000000000000000 0000000000000000000000000000000000000 22 SEQUENCE LISTING 110 Morishita Jintan Co Ltd Kobe University lt 120 gt Oral Vaccine 130 2 08 03023 4150 2007 70626 4151 2007 03 19 4160 12 4170 P
16. 00 1000 100 50 5 JP 5187642 B2 2013 4 24 20 40
17. 10000000000 100000 10000000000 100000 10000000000 10 20 30 40 50 3 JP 5187642 B2 2013 4 24 HHHHHHHHHHHHHHHHHHH 10 HHHHHHHHHHHHHHHHHHH HHHHHHHHHHHHHHHHHHH 20 30 40 50 JP 5187642 B2 2013 4 24 4 10 20 30 40 100 1
18. Gly A Leu Leu Lys Lys a Val Thr Glu tga ccttctgcto gtagogatta cttcgagcat tactgacgac aaagaccccg accgagatgg tcggggtctt tttgttgtgg tgctgtgacg tettetocaa cogtattatt coggactagt tcagcg 4210 10 lt 211 gt 93 212 gt PRT 213 Bifidobacterium longum 400 10 Met Ala Tyr Asn Lys Ser Asp Leu Val Ser Lys Ile Ala Lys Ser 1 5 10 15 Asn Leu Thr Lys Ala Ala Glu Ala Ala Val Asn Ala Phe Gin Asp 20 25 30 Val Phe Val Glu Ala Met Lys Ser Gly Glu Gly Leu Lys Leu Thr Gly 35 40 45 Leu Phe Ser Ala Glu Arg Val Lys Arg Pro Ala Arg Thr Gly Arg Asn 50 55 60 Pro Arg Thr Gly Glu Gln Ile Asp Pro Ala Ser Tyr Gly Val Arg 65 70 75 80 lle Ser Ala Gly Ser Leu Leu Lys Lys Ala Val Thr Glu 85 90 lt 210 gt 11 lt 211 gt 34 lt 212 gt DNA lt 213 gt Artificial lt 220 gt lt 223 gt Bifidobacterium bifidum forward primer 400 11 cggcaagctt tatgggggat acaggattgg cgat 210 12 6211 33 212 DNA 4213 Artificial lt 220 gt lt 223 gt Bifidobacterium bifidum reverse primer lt 400 gt 12 Ecgcccatgg aaatcgggtg gcgtcctoga JP 5187642 B2 2013 4 24 375 423 471 524 584 600 34 33 10 20 30 40 pTB6 100 2 pTB6 PBLES100 9100 bp PstI PBLES FliC 10300 bp pBR322 hupP 25 JP 5187642 B2 2013 4 24
19. atentln version 3 1 210 1 lt 211 gt 30 4212 DNA lt 213 gt Artificial lt 220 gt lt 223 gt Salmonella typhimurium forward primer lt 400 gt 1 catgccatgg atggcacagt cattaataca lt 210 gt 2 lt 211 gt 30 lt 212 gt DNA lt 213 gt Artificial lt 220 gt lt 223 gt Salmonella typhimurium reverse primer lt 400 gt 2 cgcggatcct taacgcagta aagagaggac 210 3 lt 211 gt 31 212 DNA lt 213 gt Artificial lt 220 gt lt 223 gt Vibrio cholerae forward primer lt 400 gt 3 catgccatgg atggcaatta atgtaaacac g lt 210 gt 4 lt 211 gt 31 lt 212 gt DNA lt 213 gt Artificial lt 220 gt lt 223 gt Vibrio cholerae reverse primer lt 400 gt 4 cgoggatcct ttatcccaat aagctcagag c lt 210 gt 5 lt 211 gt 30 lt 212 gt DNA X213 Artificial lt 220 gt lt 223 gt Shigella dysenteriae forward primer lt 400 gt 5 catgecatgg atggcacaag tcattaatac JP 5187642 B2 2013 4 24 30 30 31 31 30 10 20 30 40 23 lt 210 gt 6 lt 211 gt 30 212 DNA lt 213 gt Artificial lt 220 gt lt 223 gt Shigella dysenteriae reverse primer lt 400 gt 6 cgcggatcct ttaacoctgo tgcagagaca lt 210 gt 7 11 30 lt 212 gt DNA 4213 Artificial lt 220 gt 223 hup forward primer lt 400 gt 7 cgccaagctt tgggcgcgEc ggccatgaag 210 8 lt 211 gt 30 4212 DNA lt 213 gt Artificial lt 220 gt lt 223 gt hup reverse pr
20. imer lt 400 gt 8 cgogccatgg aaagcatcct tcttgggtca 210 9 211 600 212 DNA 213 Bifidobacterium longum lt 220 gt lt 221 gt promoter 222 1 192 lt 223 gt lt 220 gt lt 221 gt CDS lt 222 gt 193 474 lt 223 gt lt 220 gt lt 221 gt terminator lt 222 gt 475 600 lt 223 gt lt 400 gt 9 tggecgcggc ggccatgaag tggcttgaca agcataatct tgtctgattc gtctattttc atacoccctt cggggaaata gatgtgaaaa cccttataaa acgogggttt tcgcagaaac atgcgctagt atcattgatg acaacatgga ctaagcaaaa gtgcttgtcc octgacccaa gaaggatgct tt tac aac aag tct ctc tcg aag atc goc Ser Leu Val d Lys Ala cag aag toc aac acc aag cag gcc gag get got ett aac gcc Lys Ser Asn Leu Thr 2 Ala Gln Ala Glu nla la Val Asn Ala ttc cag gat gtg ttc gto gag gct atg aag ggc gaa ggo ctg aag lu Gly Leu Phe Asp Val Phe Val Glu Ala Met Lys Ser Gly Glu G 30 35 40 JP 5187642 B2 2013 4 24 30 30 30 60 120 180 231 279 327 10 20 30 40 24 ctc acc ggc tto toc got gag cgo gto aag CgC cog got cgo acc Leu Thr Gly Leu Ser Ala Glu Arg Lys Arg Pro Ala ae Thr ggc cgc aac cgc act gag cag att att ccg got toc tac Gly Arg Asn ro Arg Thr Gly Glu gin lle Asp lle Pro AD Ser Tyr ggc gtt cgt atc tcc got toc ctg aag aag gcc acc gag Gly Val anf lle Ser Ala
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