JP 2009-512844 A 2009.3.26 (57)【要約】 アグリカンおよび／または
Contents
1. 2009 512844 2009 3 26 112. 341 342 40 342 341 50 2009 512844 2009 3 26 6 10 20
3. 50 2009 512844 2009 3 26 3 1000 I D D 10 000 20
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7. 13 2009 512844 2009 3 26 00000 Caterson B Flannery C R Hughes C E Little B Mechanisms involved in Cartilage Proteoglycan Catabolism Matrix Biology 2000 Volume 19 333 344 Fosang A J Hardingham T E Isolation of the N terminal giobular protein domains from cartilage proteoglycans Biochemical Journal 1989 Vol 261 801 809 Fosang A J Hardingham T E 1 6 Epitope in Cartilage Proteoglycan G2 Domain is masked by Keratan Sulphate Biochemical Journal 1991 Volume 273 369 373 Fosang A J Last K Gardiner P Jackson D C Brown L Development of a cleavage site specific Monoclonal Antibody for detecting metalloproteinase derived Aggrecan Fragments in Human Synovial Fluid Biochemical Journal 1995 Volume 310 337 343 Fosang A J Last K Maciewicz R Aggrecan is degraded by matrix metalloprcteinases in human arthritis Evidence that matrix metalloproteinase and aggrecanase activities can be independent J Clin Invest 1996 98 Nr 10 2292 9 Fosang A J Last K Stanton H Weeks D B Campbell I K Hardingham T E Hembry R M Generation and novel distribution of matrix metalloproteinase derived aggrecan fragments in porcine cartilage explants The Journal of Biological Chemistry 2000 Volume 275 Nr 42 33027 33037 Garnero P Rousseau J C Delmas P Molecular Basis and Clini
8. 30 40 50 2009 512844 2009 3 26 9 n IUD 10 20 30
9. 30 40 50 2009 512844 2009 3 26 8 10 20
10. IlHHHHHH IlHHHHHHHHH 1000 eH BB BESE M EB EL 10000 100000 O O O HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH 100 00 D IU HHHHHHHHHHH 1g told TR SUF OTF RA 1 24 DA 1 AX QE 0 T T T 0 01 0 1 1 10 100 1000 10000 ng ml 2 G2 5 1 OSM INF a V FFGVG G2 OSM amp TNF a4GM6001 OSM TNF a 400 30 25 e 300 20 1 at 58 SO 5 3 od 36 5 D 100 9 0 2 4 6 8 10 12 14 46 18 20 5 ong JP 2009 512844 A 2009 3 26 3 3 R2 ne of o 1 0 T T 1 0 2 4 6 8 10 ng mg 3 24 521 Of 0 T 1 0 1000 2000 3000 ng mg 4 n OSM4 TNF a GM6001 0 05 20004 g 35 10004 04 0 5 10 15 20 Ax He 150 2
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12. 40 50 2009 512844 2009 3 26 10 10 20 30 40 L 50
13. 30 40 50 2009 512844 2009 3 26 7 10 20
14. 2009 512844 2009 3 26 19 JP DAR FA A 11 2009 512844 P2009 512844A 43 21 3 26 2009 3 26 51 Int Cl GO1N 33 53 2006 01 33 53 D 4BO65 16 18 2008 01 16 18 4HO45 C12N 5 10 2006 01 5 00 B GO1N 33 543 2006 01 33 543 5110 33 43 515D 019 ED 21 2008 536049 P2008 536049 71 508122286 86 22 18 10 17 2006 10 17 85 20 6 23 2008 6 23 86 PCT EP2006 067520 2730 87 W02007 045661 207 87 19 4 2 2007 4 26 74 100099623 31 0521392 1 4 32 17 10 20 2005 10 20 74 100096769 33 BH Et AR 31 0608947 8 74 100107319 32 18 5 5 2006 5 5 33
15. GE 74 100114591 74 100118407 54 5 0000 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH 2009 512844 2009 3 26 2 10 n 20 30 40
16. 18 January 2007 05 02 2007 Name and mailing address of the ISA Authorized officer European Patent Office 5818 Palentlaan 2 NL 2280 HV Riewijk Pe Ra N LOS NON Van Bohemen Charles Form PCTASA 210 second shest April 2005 18 2009 512844 2009 3 26 INTERNATIONAL SEARCH HEPORT Information on patent family members Patent document cited in search report International appilcation No PCT EP2006 067520 Publlcation Patent family Publication data member s date WO 9718194 A 22 05 1997 213232 T 15 02 2002 AU 707707 B2 15 07 1999 AU 7562496 A 05 06 1997 BR 9611479 A 13 07 1999 2237590 Al 22 05 1997 CN 1202156 A 16 12 1998 CZ 9801453 A3 12 08 1998 DK 861236 T3 21 05 2002 EP 0861236 A1 02 09 1998 5 2170884 T3 16 08 2002 HU 9903405 2 28 04 2000 JP 2000509145 T 11 01 2000 PL 326702 1 26 10 1998 PT 861236 T 31 07 2002 RU 2164914 C2 10 04 2001 TR 9800849 T2 21 07 1998 US 6207672 B1 27 03 2001 Form POT ISA 210 patent family annex 2005 19 2009 512844 2009 3 26 1000000000 80000 LS NA SD SL SZ TZ UG ZM ZW EA AM AZ BY KG KZ M RJ TJ TM EP AT BE BG CH CY CZ CK ES FI FR GR HJ I E IS I T LT LU LV Mc NL PL SE 51 55 TR OX BF B MG QN Q GYM SN TD TG AE AG AM AT AU AZ BA BB BG BR BWBY CA CH
17. ng mi 5 0 RAD 7 16 2009 512844 2009 3 26 AF 28 ng ml RA 17 2009 512844 2009 3 26 INTERNATIONAL SEARCH REPORT International application No PCT EP2006 067520 CLASSIFICATION OF SUBJECT MATTER INV GO1N33 68 C07K16 44 C12N5 12 According lo International Patent Classification IPC or fo both national classification and IPC B FIELDS SEARCHED Minimum documentation searched classification system followed by classification symbols GOIN CO7K 12 Documentation searched other than minimum documentation to the extent that such documents are included In tha fiekis searched Electronic data base consulted during tha intemational search of dala base and where practical search terms used EPO Internal WPI Data BIOSIS EMBASE PAJ CHEM ABS Data C DOCUMENTS CONSIDERED TO BE RELEVANT Citation of document with indication where appropriata of the relevant passages Relevant to claim No MO 97 18194 A HOECHST 6 22 May 1997 1997 05 22 page 49 lines 1 5 VILIM V ET AL Proteogiycans isolated from dissociative extracts of differently aged human articular cartilage characterization of naturally occurring hyaluronan binding fragments of aggrecan THE BIOCHEMICAL JOURNAL 15 DEC 1994 vol 304 Pt 3 15 December 1994 1994 12 15 pages 887 894 XP002415590 London
18. CN QQ CR QJ CZ LE DK EM LZ EG EG ES FI G1 GM GI FN FR HJ IDIL IN 1S JP KE KG KM KN KP KR KZ L A LC LK LR LS LT LU LV LY M MG MY NZ NA NG NQ NZ OM PG PH PL PT RS RU SC SD SE SG SK SL SM SV SY TJ TM TN TR TT UA UG LE LZ W ZA ZM ZW 74 100125380 74 100130960 74 100125036 74 100142996 72 HHHHHHHHHHHHHHHHHHHHHHHHHHHH OOO 2000 HHHHHHH HHHHHHHHHHHHHHHHHHHHH HHHH 1000 00 48065 AA90X 25 44045 AA1 AMO AA30 DN6
19. UK ISSN 0264 6021 page 166 column 2 paragraph 4 Further documents are listed in the continuatlon of Box C Seo patent famlly Special categories of documents T later document published after the international filing date iory dale and not in conflict with the application but document defining the general state of the art which is not prior considered Yo be of parilcular relevance d understand the principle or theory underlying the eariler document bul published on or afterthe International X document of particular relevance the claimed invention filing date k cannol be considered novel or cannot be considered to document whlch ino double on priority e Involve an inventive step when the document ls taken alone EE estabiish the pu n dale of another document of particular relevance the claimed invention challon or other special reason es specified Cano ba considered to involve an inventive siep when the document referring to an oral disclosure use exhibillon or document ls combined with one or more other such docu other means ments such combination being obvious ta a person skilled document published prior to the laternatlonal fling date but in the art iater than the priority date claimed 8 document member of the same patent Dale of the actual completion of the International search Date of mailing of the Iniemalional search
20. cal use of Biochemical Markers of Bone Cartilage and 10 20 30 40 14 2009 512844 2009 3 26 0000 Synovium in Joint Diseases Arthritis and Rheumatism 2000 Volume 43 No 5 953 968 Hardingham T E and Fosang A J The Structure of Aggrecan and its Turnover in Cartilage The Journal of Rheumatology 1995 Volume 22 1 supplement 43 86 89 Kongtawelert P and Ghosh P A new Sandwich ELISA Method for the Determination of Keratan Sulphate Peptides in Biological Fluids employing a Monoclonal Antibody and labelled avidin biotin Technique Clinica Chimica Acta 1990 Volume 195 17 26 M ller J Larsen S Ingemann Hansen T Poulsen J H ELISA for the Core Protein of the Cartilage large aggregating Proteoglycan aggrecan Comparison with the Concentrations of Immunogenic Keratan Sulphate in synovial fluid Serum and Urine Clinica Chimica Acta 1994 Volume 225 43 55 Ratcliffe A Shurety W Caterson B The quantitation of a native chondroitin sulfate epitope in synovial fluid lavages and articular cartilage from canine experimental osteoarthritis and disuse atrophy Arthritis and Rheumatism 1993 Volume 36 No 4 543 51 H E EE
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