EGFR pharmDx「ダコ」
Contents
1. 4 5 1 2 32. EGFR 120883 003 1
3. K1492 K1494 K 8mLx1 11mLx2 8mLx1 11mLx2 EGFR 2 18C9 4mLx1 12mLx 1 IgG1 4mLx1 11mLx1 sh ck i fh hi 70 8mLx1 11mLx2 500 30 10mLx1 11mLx10 3 3 1mLx1 3mLx2 1Lx1 1Lx2 2 5 x1 5 x2 CAMA 1 EGFR
4. 4 15 25 2 5 6 20 25 C 4 6 EGFR 7
5. 2 5 3 5 5 5 2 30 30 5 2 30 5 2 5 2 1 5 5 3 4 pH8 0 1 1 1 50vol9 3 70vol 3 80vol9 3 95vol9 3 100vol 3 100vol 3
6. 3 3 DAB DAB 3 83 003 1 2 2 3 3
7. 1 2 1 mL 1 25 30uL 2 10 2 8 8 3 4 1 2 3 100L 5
8. 7 8 B HBs 9 10 Fc Fc
9. 2 3 C 4 5 6
10. 8 3 100xL 30 5 5 9 10 100xL 10 5 11 1 5 5 12 pH8 0 SSJP016 1030816 3 1
11. EGFR EGFR 2 2x2 5x0 5cm 5 50 24 48 3 70vol9
12. 2006 2007 201 92 8 98 0 EGFR EGFR 1 EGFR 2 0 1 0 2 EGFR HT 29 EGFR
13. 15 7 1 2 3 4 5 6
14. EGFR 50 90 40 80 40 80 36 100 35 70 33 74 25 77 14 91 EGFR 79 EGFR EGFR ATP
15. 1 15 16 3 3 9 17 1 1 Code No S3003
16. 60 EGFR 4 m 40 3 C 20 25 C 4 6 100vol 5 100vol 5 100vol 5 100vol9 3 100vol 3 95vol 3 80vol9 3 70vol 3 50vol 3 3 3 3
17. 0 EGFR 2 0 1 0 HT 29 1 EGFR 228 08ng mg protein 2 5 0 5 CAMA 1 1 EGFR 35 000 0 1 HBV HIV 2 3 4 5 6 3 3 DAB
18. 4 10 20 gt EGFR G Q HT 29 HT 29 CAMA 1 CAMA 1
19. 16 36 TEL 03 5232 9968 108 0023 16 36 TEL 03 5232 9970 FAX 03 5232 9969
20. 8 2 8 C 16 9 10 11 12 13 14
21. 2 5 0 5 3 EGFR CAMA 1 EGFR 0 1 EGFR HT 29 EGFR 2 5 0 5 0 2 EGFR CAMA 1 EGFR 0 0 EGFR HT 29 EGFR CAMA 1 3 HT 29 EGFR 2 5 0 5 CAMA 1 EGFR
22. 3 5 3 4 3 100xL 5 3 5 5 6 3 100wL 30 5 5 3 100L 7
23. 100vol 3 100vol 3 100vol 3 100vol 3 2 EGFR EGFR EGFR 1 2 EGFR 3 4 EGFR
24. S4103 1 JIS K8271 2 100 95 80 70 50 1 0 05mol L pH7 6 6 19 50mL 1mol L 37mL 1L pH7 6 0 2 25 C 2 3 Code No S2020 4 5 pH8 0 5 H amp E 1 EGFR 1 1 2
25. 7 8 1 121 C20 1vol 2 3 2 8 C 1 Code No
26. 0 HT 2 9 EGFR 2 EGFR 1 2 3 1208 EGFR EGFR EGFR 2 18C9 lt
27. EGFR pharmDx K1492 35 EGFR pharmDx K1494 50 1 Press MF Hung G Godolphin W Slamon DJ Sensitivity of HER 2 neu antibodies in archival tissue samples Potential source of error in immunohistochemical studies of oncogene expression Cancer Res 1994 54 2771 2 Fahimi HD Gray BA Herzog VK Cytochemical localization of catalase and peroxidase in sinusoidal cells of rat liver Lab invest 1976 34 192 201 3 LiCY et al Use of azide and hydrogen peroxide as an inhibitor for endogenous peroxidase in the immunoperoxidase method J Histochem Cytochem 1987 35 1457 1460 4 Elias JM Gown AM Nakamura RM Wilbur DC Herman GE Jaffe ES Battifora H Brigati DJ Special report quality control in immunohistochemistry Amer J Clin Pathol 1989 92 836 5 Omata M Liew CT Ashcavai M Peters RL Nonimmunologic binding of horseradish peroxidase to hepatitis B surface antigen A possible source of error in immunohistochemistry Amer J Clin Pathol 1980 73 626 6 Normanno N Maiello MR Luca AD Epidermal growth factor receptor tyrosine kinase inhibitors EGFR TKIs simple drugs with a complex mechanism of action J Cell Physiol 2002 194 13 19 7 Umekita Y Ohi Y Sagara Y et al Co expression of epidermal growth factor receptor and transforming growth factor alpha predicts worse prognosis in breast cancer patients Int J Cancer 2000 8
28. 9 484 487 8 Nicholson RI Gee JM Harper ME EGFR and cancer prognosis Eur J Cancer 2001 37 Suppl 4 S9 15 9 Grandis JR Melhem MF Gooding WE et al Levels of TGF alpha and EGFR protein in head and neck squamous cell carcinoma and patient survival J Natl Cancer Inst 1998 90 824 828 10 Nicholson RI Hutcheson IR Harper ME et al Modulation of epidermal growth factor receptor in endocrine resistant etrogenreceptor positive breast cancer Ann N Y Acad Sci 2002 963 104 115 11 Huang SM Harari PM Epidermal growth factor receptor inhibition in cancer therapy biology rationale and preliminary clinical results Invest New Drugs 1999 17 259 269 12 Baselga J The EGFR as a target for anticancer therapy focus on cetuximab Eur J Cancer 2001 37 Suppl 4 S16 22 13 Herbst RS Shin DM Monoclonal antibodies to target epidermal growth factor receptor positive tumors a new paradigm for cancer therapy Cancer 2002 94 1593 1611 14 Woodlburn JR The epidermal growth factor receptor and tis inhibition in cancer therapy Pharmacol Ther 1999 82 241 250 15 Raymond E faivre S Armand JP Epidermal growth factor receptor tyrosine kinase as a target for anticancer therapy Drugs 2000 60 Suppl1 15 23 16 Waksal HW Role of an anti epidermal growth factor receptor in treating cancer Cancer Metastasis Rev 1999 18 427 436 108 0023
29. SSJP016 1030816 3 87746 27 4 4 2 8 3 22000AMX02113000 EGFR pharmDx 1 EGFR 2 3
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