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1.
2. A9 3 1
3. E
4. 2
5. 491
6. 3
7. 6 yaya ME WR
8. c d e f g h 3
9. 2 4 2 OPPTS 835 2210 OPPTS 835 5270 OPPTS 835 2210 1
10. 3 A9 1 8 A9 1 9 A9 1 2 3 1 A9 2 3 4 4 1 4 1 2 11 3 A9 4 2 2 BADE A9 4 2 2 1 ORECD No 301 OECD 1992 OECD
11. A5 2 2 7 N 1 1 2 REBUN VA ADI
12. K A9 3 1 d E
13. A9 4 2 2 3 10 MTITTI I OECD 801O OECD OECD 801 10 OECD 301D 10
14. A9 4 2 2 2 OECD 100mg OECD 209 ISO 9509 ISO 11348
15. QSAR i en ea 1H 2 QSAR
16. EEES 1mg 1 AR ie ie EO ERE Agia ihe EO HERE ae 483
17. GHS 3 4 1C 459 ge Ih w w JPEE 1
18. 20
19. 2 A3 3 4 6 A8 3 4 7 1 4 4 1 amp 8
20. OECD 1995 Nyholm Ingerslev 1997 2 3 a b c d
21. A6 5 11 2 A6 3 2 20 2 441 A6 3 aie 60 120 30 45 45 75 75 105 20 30 20 30 20 30 45 75 lo a ajo e wl wv 30 ja 30 45 pi 120 180
22. A9 1 5
23. A 426 A5 2 2 5 A5 2 2 6 GHS
24. OECD 1995 Cte Dis 2 8
25. A9 8 5 6 TZEE A9 3 5 6 1
26. A9 1 7 A9 2 Wd
27. a 470
28. 34 j T i J J OECD Environment Health and safety Publications Series on Testing and Assessment No 27 Environment directorate Organization for economic Co operation and Development April 2001 467 A9 1 6 EHR
29. EDTA EDTA Ty 478 A9 3 3 5 QSAR OFJ
30. 3 8 ERMYHEEDO LIE 3 8 1 Syracuse Research Corporation Biodegradability Probability Program BIOWIN OECD 1993 peas 1996 Biodegradability Probability Program BIOWIN ee
31. 8 SDS SDS SDS a SDS SDS 0 SDS Eee ht ah c eae ae m
32. 9 3 3 1
33. A9 4 3 5 4 MITT D AR OECD 3010 OECD 301E 100mg l OECD 2 10mgl OECD 209 TSO 9509
34. ral E Ds ul IH HAL JRR b UR EUEN E
35. 621 3 8 3 EU 115 9 1 US EPA EC 3 8 4 EU TGD EC 1996 EC 1996 3 8 5 Biodegradation Probability Program VW OECD 1994 Biodegradation Probability Program
36. A9 7 5 BEP EUREMA BIT 3 PAEDAH A9 7 5 1 A9 7 5 1 1 TA E a BIBER E DEC BIT 3 ZAHM OBE OF z H COME 7 E a BCF Eee RET EDERS FOI
37. 624 3 1 2 WED 4 DE Monod 50 E OECD 1995 4 OECD 1995 3 1 3 10 gM
38. 8 I 8s ce pg 91 2
39. pH pH4 7 9 50 5 10 3 pH 4 7 9 OPPTS835 2130 OECD 111
40. A9 3 2 2 GHS OECD 1998 BUELL A FARE 1 PE CO 96 FE LCso ff OECD 208 F KALIEO BD PRH 1 PECO 48 FEY ECs ff OECD FX ROH 202 FAZE
41. 4 1 4 1 1 4 1 2 100mg li TETE BCF 500 BCF log Kow 24 A9 2 5 7 2 OFF TRE
42. 2 A6 5 8 3 440 A6 5 8 4 A6 5 9 HVGFFORAE
43. Schwarzenbach 1993 2 2 Schwarzenbach 1993 3 4 2 3 2 3 1 HaO OH A
44. SDS 4 A6 3 6 A6 3 1 SDS
45. A9 4 1 3 FF ORLA A9 II BEE A9 1 RARR 485 A gh 10 A9 7 A9 4 2 MEMES 2 OER A9 4 2 1 aR DEH
46. 1 2 8 2 3 4 1 E 5 2 2 3 2 3 4 1 OF 3 F 270 A2 4 ae ae EE
47. im A9 3 2 ARORH A9 3 2 1
48. 2 83 1 BE ae 7 334 A
49. A9 7 2 A9 7 2 1 KEZET Z DOREIR A9 7 2 1 1 A9 3 508 BI OIKERIET 2 BL ORES 2 DRA Me UT KAM E i RRE TC A9 7 2 1 2 amp A9 7 2 1 2 1
50. 308 A3 2 1 1 2 3 4 5 P101 P102 P103 A8 2 2 1 2 3 4 5 P201 2 1 3 5 1A 1B 2 3 6 1A 1B 2 3 7 1A 1B 2
51. Ni A9 3 5 10 AWE A9 3 5 10 1 WSBF WAF L E Cso LLso CH ANS WSF WAF A9 3 5 10 2
52. a 5 Le c 5 ul kzi gt A9 1 10 OECD
53. EDS 1mg7l 4 FE LE Cso gt 100mg 1 Pole E 8 amp A9 2 4 4 6 BCF BCF 500 BCF log K 4
54. AG6 5 6 2 A6 5 6 8 1 SDS
55. 3 5 97 STP OECD 303A Coupled Unit ISO 117383 EU C 10 eae 1996 3 6 SEMI DAPIE 3 6 1 ISO 11734 1995 E ASTM E 1196 92 OPPTS 835 3400 3 6 2 8 a b
56. G EYED Spiel 3 Vlabors RRt KORE OI EOE BAVHEETRIAT IRE HELENS LUE EB UE BORGER ERNE L TW BRS THREE 493 PZZ OFAI RRE SB CWRU RLGHIO Gi VC 0 5 Gui iv QSAR Biodegradation Probability Program lt 1 FF A E PEO IL
57. log Kowt x at A9 6 4 9 3 log Kow 6 6 5 log Kow 83 Bruijn 1989 QSAR log Kow log Kov log Kow
58. A9 7 ffi A9 2 A9 2 1 GH EU A os 2 3 4 Ai 2
59. a 4 3 aA 20 25C W 35C
60. WAFS E pH
61. A4 3 8 3 3 Hi PERE IMCL TS SNF PRIZ OU CIE EEE CBD 22 COPE E T OBA OS Bota FEE DIAC EE SHE WAH ENDARA BIT E BREED AMG EN OWE EERIE Ep A4 3 3 1 FBA A4 3 3 1 1 FGAEOL FHES GHS ERD KAIRIEFE IZ LIECT BAIT CAS 4 Eit TUPACH CL A4 3 3 1 2 FEO EWG 408 A4 3 3 1 3 fEFYAO CAS BF EZOMODKEF CAS
62. NM PS SN 2 EMI SE A5 1 5 GHS SDS
63. Ake A9 1 12 v A9 4 A9 1 18 A9 5 BCF QSAR
64. BER SDS 8 eA L OREH EDY E TNX CHS R NN A w A4 3 14 1 H RE 4 4 i A4 3 14 2 TEHKE HH GHS
65. 1 A4 3 8 2 BWLIFHK FHL E iD 72 S a SDS 1 ILO E a b
66. log Kow te 1 a a mitt TZ n HLL A9 6 4 KEREASHEAH O QSAR DEHA A9 6 4 1 a b c LT THAD d e E f Fe H n log Kow E BCF 4 tet 503 et a s E
67. QSAR QSAR CO KE FR n E E 3 2 To E
68. 2 Hope ly 1 10mgC l E oO TA
69. 2 GHS E a H v 416 E A FAB LOS
70. OECD 3 301A OECD 01D DOC ORCD ORCD 301E OECD 801 A9 4 3 5 6 _ OECD 301D MITI 1 OECD 301C ORCD 301F
71. A9 4 2 4 8 OECD 302 70 2 TEEKI 4 EBIT S OECD PEZET Z o DEVE ONEPRIZ OWT REA BUDRUCIAT E EU OFFAL RAT T OSB CAULKRAWADAEARIE LS bb SOF 2 amp BIEL ITE LTU CB FORA TX
72. ry TI A9 1 14 QSAR 3 QSAR QSAR QSAR 1 1
73. 2 3 3 1 BROZORE 8 1 1 g 1 2 100mg l 10zg l OECD 1995 Scow 1982 az
74. A9 3 5 6 2 L Cso
75. 2 3 4 j NOEC A9 7 5 3 BEORREN A9 7 5 3 1 LE Cs 100mg l A9 7 5 3 2 gt L E Cs0 A9 7 5 8 2 1 24 28 NE RE CS ONE DR
76. A4 3 1 4 PRA OFS A4 8 1 5 KABB F SDS my II ul j SDS 8 6 24 407 A4 3 2 2
77. bs MEIC NN A9 2 4 A A9 2 4 1 a b L E Cs0 c NOEC EC d
78. KEY RD BYGK AR EGE P411 P220 C l P420 P234 P280 35l 2 9 1 H250 P210 P302 P334 P422 BVA TERAIRIEO DOOL I REKHA DOR AM P222 P280
79. a 0 1 8 4 5 b 1 0 GER RUHR DE 5 BADHA E P CE EOIN SB LOVED 1A penis V F 2 ZAYOF ZRAFT COA DRE OR H 3 4 3 2 BLA ee gt j OSRD 5 ore omenmM sini EA Ratnhota TRAE 7 vn Pek 1A 0 1 ie 1 MERURRT 4 OD 5 BADHA BT TOZET ae 2 BABOF K BAF CER BA TREO is 3 4 3 2
80. E A9 3 A9 3 1
81. A5 2 2 9 4 CPSC E 100 1 427 10 11 12 ILO 1999 Current Sector Uses of Risk Communication IOMC ILO HC3 99 7 A Venema M Trommelen and S Akerboom 1997 Effectiveness of labelling of household chemicals Consumer Safety Institute Amsterdam Leen Petre 1994 Safety information on dangerous products consumer assessment COFACE Brussels Belgium European Commission 1999 DGIII Study on Comprehensibility of labels based on Directive 88 8797 EEC on Dangerous Preparations Magat W A W K Viscusi and J Huber 1988 Consumer processing of hazard warning information Journal of Risk and Uncertainty
82. A4 3 8 1 BHT XR 2 H oA SILO ul A4 3 8 1 1 4 L ap PEAR BER IMEO H FE E L TIE 1 E SDS HH SDS
83. A3 1 2 A3 1 2 1 a X H hazard Statement b 2 3 4 c 200 210 220 230 A3 1 1 Z ARAE A3 1 2 2 A3 1 2
84. A9 7 5 3 2 2 L E Cs a L E Cs 1mg l 1 b LE Cs Img 10mg l LAS 1 2 2 c TOOn 10mg 100mg1 3 Tr LE ELOEMETAVED RMD MG IZOTERMA LA 3 A9 7 5 3 3
85. F d 5C 25C e 28 709 16 A9 4 2 4 6
86. A4 8 1 1 GHS DEERE GHS SDS SDS SDS A4 3 1 2 fUDFFREFR A4 3 1 8 6s OMRAE E EA LOMB
87. 1 2 OECD OECD 1995 1 3 a b c ao ce oT Ww
88. A6 5 7 ZI 7AE 11 A6 2 8 6 2 8 at 10 5 5 ene 6 10 A6 5 8 Kz AG6 5 8 1 CHS
89. 2 f AN a DOC 70 3 14 zk H Sy ETTIBVE CSE 10 E 3 16 28 Po e E OR NE NN BAD LD REC ERE IT
90. 1 5 1 5 1 r CA 3 2 SDS GHS SDS SDS A4 2 2 ARHIFS amp GHS A4 2 2 1 SDS SDS
91. 473 1H g MM HTE HH FUL a o s EU USEPA 797470772 Hfi Peele ks bleu Hh c d ae
92. 1 2 3 4 5 P315 EAA 2 5 P320 E 3 1 1 2 EE OM FERID RGD BARGA P321 3 1 1 2 3 E A OMEN ORG BLELGE 3 1 3 KADEN MLE DBL EGGS 3 2 1A 1B 1C 3 2 BH 2 REA RAR FALE BITE 3 4 1 1A 1B WETS EMD LATA OED a caste HERR 3 8 1 BAOMEBLELGE P322 EBL 3 1 1 2 EBL 3 1 3 4 JEE OVEPAIOD E S REAMEES DON SHAA P330 3 1 1 2 3 4 8 2 1A 1B 1C P331
93. 558
94. gt i IOMC ZL 5 MRM AFA GHS OFA SH SAH ZORE IFCSASG3 98 32B 425 A5 2 A5 2 1 GHS AZ OU ATF a GHS 1 GHS b
95. A3 2 8 8 2 P280 A8 2 3 4 2 8 RR a i ED A3 2 3 5
96. OECD ae ead e QSAR QSAR O Ci T A9 2 6 2 Dat E
97. A9 4 3 5 2 a HEFE b c d e A9 4 3 5 3
98. A9 2 3 3 A9 3 3 2 2 A9 2 8 4 1 pE 471 Pagar a Bet f E
99. P372 P230 PLES LEAR TE RIEL GA ELRE PEUZ LO IRISA RIEDR HT AG A he P240 P250 Es ROEA AE E EPE ESTAI ET D ELAS P280 P373 339 2 2 KR 1 H220 a
100. ERED RIRE e RRC RES NATOA KREN mMOATHA c men aia A5 2 2 err A5 2 2 1 A5 2 2 2 GHS
101. Ft 4 FX G gt ES FE NOEC 2 482 LGE Cso YD L E Cz0 3
102. A9 3 2 4 OECD 1999 EPA 1996 ASTM 1999 ISO EU OECD No 11 H E 475 A9 3 2 5 HZH EAE A9 3 2 5 1 H ERRER bfi
103. P321 P270 KA OMBH ORG BELELGE P330 365 3 1 3 H301 P264 P301 P310 P405 P501 P270 P321 EA OMBA OLE G BEALE P330
104. E 60 70 CO a Ce ee Be NN VW d e BODs COD 7 28 re a 3 lt 16 28 70 BODs COD 0 5 E
105. OECD t OECD 2000 I EJEM E nas 479 K Boke L Cs 4 E
106. E Be f ARS 1 QSAR QSAR
107. OH W B B 4 pT m A9 7 5 4 3 RMORICKHTE IC PRET DRT R e RAMRICLoCRRS K SW Dr A9 7 5 4 4 OECD 2001
108. c 9 2 9a d 10 2 8 saat 9 o 11 ij e 11 2 10 1 2 8 9
109. A4 3 11 15 ZCOMOFR pu ua GHS A4 3 12 12 A4 3 12 1 A4 3 12 38 A4 3 12 7
110. SDS 3 A4 3 8 1 2 SDS 4 A4 3 8 1 3 pees jij SDS E SDS 3 H
111. 8 P271 ee P312 LB DARA Ae ER EI ELBE EAE EDA P405 391 3 9 1 H372 lt lt gt gt lt gt lt gt LDAPULI NS COREE ZT OMG EAT S lt lt gt gt Clk MORIE 5 ORDA E CLS EBREHNUC HEY SM TOSHE AECI E RRI S P260 P314 P501 BU ANBIN AIS Z KREUAT V EBA Liz
112. 1 10 100mgl 100mg l OH 7 mg l A10 2 3 2 pH 5 5 HH 6 8 5 8 5 pH pH Imm A10 2 3 3 pH 28
113. 468 a NO OMA WROTA IRE OMAK LOKA BEART ORE DHE L HE DDED L E Cs b E NOEC
114. SDS SDS 1 3 RIX 1 5 83 3 SDS A4 2 4 3 SDS 7 1 NESTE SDSEAATT ERECT RRATZEN EOJ K ECE EI ELL SDS TOURED PREAFE CEBEWIZLEW I 406 A4 2 4 4 A4 2 5 A4 2 5 1 SDS
115. TREE ROOREAIZST SAE EF ERE 2 6 2 B FR ae TF 6 1 2 3 4 5 He TEERADA I SME EF HRAJTE SIV TVYZRVY i rN fn S ft 6 2 WY 6 Dae gt Be A F 258 1A 1B 1C 2 3
116. Gi 3 2 3 1 5 3 3 1 SIROTA LEGQYIDF 2 BAF CERLV GE ORE OFA ZA 3 3 3 2 38 DLE ORM OH SNR OREN a e ae 3 1 b 1 1 1 3 3 8 3 4 REUHES 281 A2 19 ARIEXTS 3 EBLE RIVE EI 8 3 EE GEE ete WARORRT 2 Of BADHE a FRAG ZR AZINE e HAS IV CWS b
117. 1 2 3 4 5 P264 RHI ESISEL HEX RERA tE HERR 3 8 1 2 fie 3 9 1 i P270 3 1 1 2 3 4 ee 3 1 1 2 3 7 3 8 1 2 3 9 1 P271 3 1 1 2 3 4 3 3 8 3 3 8 P272 3 4 1 1A 1B P273 4 1 1 2 3 LEE LMELI IML 1 2 3 4
118. etnies 1998 GHS MM GHS RE Kin OPERA ETAL IA TY A PA DORRIT 0 THOTE Lly Ai SE Fits amp BIATIUE T V J BERBER L TREO Bon E EIAN UCB CLEMO C OKIDOXSRERET B ED AHA LS J A5 1 2 GHS
119. oma BAK BROMA REE MAL DED PAG IN aha i 6 ss ete ae Fr fp EE gt P EMRE 3 ILE EMI BLOT YR OBHEICNS OR ILE oe eee te ie awe BURATICRR TR OTT RERA SEO TRO HER EET 5
120. 1 2 432 A6 1 1
121. P264 P270 392 3 9 2 gee H373 felicpeS EEI gt gt Lk ARa OREOB EI lt gt CI LDAPULI NS COREE ZT OMELET S lt lt gt gt Clk MOED D OBE BAS CLAWS EBREHUC HE At TOSHA HERI E RRI B P260 P314 P501 BD CANEIA AIS ARRAS U ERMALZE 393
122. A9 4 2 4 5 a ee a gl b c 1 Iml 103 106 487
123. ae P281 386 3 7 1 H360 lt gt lt lt gt gt 2 H361 AEREREE ITI NOY BO REIORE lt gt lt lt gt gt lt NE LAUZE BONARELRERT Z lt lt gt gt CI MORO ORESH ETRU E DEKNE MEA APU TOSE AEREE MET Do P201 P308 P313 P405 P501 P202 P281
124. GHS SDS SDS ral a AG6 3 5
125. Pedersen 1995 A9 4 2 5 ZF 2 BAF CER EGE A9 4 3 SFRIZDI CORN 22 A9 4 8 1 KHERYA
126. SDS SDS A6 5 8 2
127. Skeaff 2000 VI 5 L E Cs0 E etn aa Ei 614 A9 7 1 YES L E Cs0 gt 100mg L _
128. A4 3 10 1 2 A4 8 10 2 FHIEH A4 3 10 3 SERA BL THEE
129. CATS AMIDE DED ILI 3 E A Mae ERD EIEHR 2 WACES ORE E ELAR EMAC RRI 3 A4 8 4 4 o A4 3 4 1 BETIA EDORA A4 3 4 1 1 ZNENDRREK OZ COWS AU
130. A6 3 2 3 11 A6 3 3 3 4 6 7 8 9 SDS SDS A6 8 4
131. a G G Gi Gy v vi b i ii iii iv v vi ES c i Gi d i G Gii iv 412 A4 3 8 8 Hi Reh LORE ERRA 253
132. A3 3 5 A3 3 5 1 GHS A3 2 2 1 335 2 1 B J H200 Sf R P201 P372 P401 P501 P202 P281 P373
133. E pH el 2 7OFE 1 Organi
134. 3 SDS SDS SDS no N pe JN Se Whee 2X 5 N ee eure tee TOS E E eae P Hh JEEE e a J A PNAS BO AiO ica orn CAs nen bea nee 7
135. E R PMA FIANLHGYOROS 2BAF CE BHAA CDP KEFVE TANEET B A4 3 12 7 MOA SEE A4 8 13 18 A4 8 13 1 AEA 1 A4 3 13 1 1 A4 3 13 1 2 A4 3 13 1 3 A4 3 13 1 4 A4 8 13 1 5 A4 3 14 14
136. TL gt fet BAE ly 3 2 3 3 2 4 TRE ars R N E LKR
137. BCF o gt v TA 1 IS BCF BCF BCF 59 OECD 305 1996 Pedersen A9 5 2 3 8 3
138. e 4 EE vV VC ORE A B C 3 2 1 2 BAYDF PLBAFE CER EA DRX OF EIZ R 8 2 3 2 3 2 3 2 1 3 DLE ORB SNR E a 5 b 1 3 2 3 8 4 as 1 DARURI Ob SiO 5 a 4 E5 eee 2 c
139. 10 Mm r k I
140. 1 c L E Cso d ao N IT YH ar a b
141. QSAR QSAR DS A9 6 4 13 BERS LL aot BREE log Kew HE
142. pH 5 6 Scow 1982 a Wh lt pH 5 8 pH 4 5 KEHOE 526 1 BCF 1 1 hee 9 BCF K s H
143. A4 8 5 1 IAKA A4 3 5 2 MFD DE CEF EDRBRHE W a b k A4 3 5 3 HELA ORWLAS EF BBE A4 3 5 3 1 KIAR k o TIRER A4 3 6 6 SE
144. A4 8 14 7 MARPOL73 78 ES II TBC Codez7 IMO MARPOL73 78 II TIBC Code A4 3 1 1 IBC Code17 18 IMO MEPC 2 Circular UN EF ARE IL PEERI EE ORPI IRE LET NAME V9 IMDG Code i KI AN EER A PEWS ADR 21k KAT AN IE TOIR OBAM I IAT 3 BINGE V5 RID EX KAT ZNZ BRUNE L OERO AXI BIT BN WEE VD ADN 1t KAT ARK MERKI E SIERO nX BIT AIMEE J MARPOL 73 78 12 1973 EOR BFR OBIE DZ O OLMREKN BIT 3 1978 DEEB EVI 10 IBC Code t SERIEZ hr CIF EZE O b OMMAO PER DR BITS HRANE 3 Ne 0 Aa Q a e 420 A4 3 15 15 8 SDS
145. c NOEC EC NOEC LCs NOEC NOEC NOEC
146. 274 A2 12 2 12 1 1kg 10 ee ee 1 1kg 20 1 ite pte ease 1
147. A4 3 12 2 AFAR A D A4 3 12 3 IMEJAA PRHA WAB E A4 3 12 4 ZERIE E PREE
148. KAZ b gt OCHS 2 10 SORE E ao EE A6 4 1 2
149. Ks So RETHA E 103 105 m1 2 DNM A 3 2 COMODEBAZORPTE 3 2 1 1000 3 2 2
150. SDS SDS 433 A6 1 4
151. p 623 24 2 5
152. 366 3 1 B 4 H302 P264 P301 P312 P501 P330 P270 367 3 1 BL 5 H303 P312 368 3 1
153. 1 2 3 4 5 P3870 KOHE BEX 2 18 1 2 3 he 2 14 1 2 3 P371 2 18 1 2 14 1 P372 2 1 7 48 BRBLOCORAD ee BEKRELINOGE P373 2 1 1 1 1 2 1 3 1 4 1 5 P374 2 1 1 4 1 49 PERL UZORA ZEKORRA P375 2 8 AB 2 18 1 2 14 1 P376 2 4 1 P377 2 2 1 2 P378 2 6 H 1 2 3 4
154. HAVO BCF Sb log Kow 2 hey AL TWYS Bil K log BCF log Kow E BCE OECD 305 1996 a NN E n Kow on Q 2 EFAB QSAR Kov
155. 492 A9 4 3 6 borg RRT CICBITSE f 3 A9 4 4 HEXF A Fox a b LT E
156. 11 436 A6 3 6 H A6 3 7 AE FRACTAL TIL FHL 1 3
157. A10 5 1 10 A10 5 1 9 6g cm3 509 8 m A10 5 1 9 25mm 0 2 u m PES O8um 5
158. BROKE HDB stn fil 2 1 LEB HID Te OFFA eas em E FISHED I a gt 4 8nm BCF EE BCF 1H Black 1991 2
159. Be ee A4 3 10 4 HIIS NER ai 415 A4 3 10 5 2MkFEIEMA FEE a X A4 3 10 6 H EZDI ER H HIERE BEN Z E EITEAN SDS 5 A4 3 11 11 A4 8 11 1 a a b HE
160. 362 2 15 B C H242 D H242 BATE H242 F H242 P210 P411 P235 P501 BUKERE EO b O OL I ARAM DIR C P220 P410 P420
161. A6 5 4 439 A6 5 5 PERE AE FRET FEIL CORR AY AAD AUR BES ORV SEE CHOOC RRRA REIREI A6 5 6 BkBLOAFE A6 5 6 1
162. A9 4 3 3 28 HLF BEA A9 4 3 3 1 MITI 1992 28 28 BODsCOD 0 5 10 a 5
163. CN HH AME M NOs 1 MT F
164. 477 S O a mM EIEN HA 0 1mg7I 1 0mg 1 UK 0 1mg 1 1 0mg 1l 1 1 EFE E2 EDH La Y 1 Se a 8 b 1 2 RERE Y Od SIGE ICO CIE
165. t 25 mm 140 a 100mm 140 C 25mm 140 C CHEN HE 8m3 100mm 140 C 25mm 140C 100mm 1 120C TE 450 100mm 140 C CHENG bi BLO 25mm Z 140C 100mm 100C
166. A9 7 2 2 4 gt 100mg pH 3 1 mel 7 1 t 4 A9 7 2 8 KEZEMET Z E BRIE 2 OLB L E Cs0 pH pH
167. BH BHRE Se A6 2 A6 2 1 4 a 1 2 11 A6 2 SDS b 2 8 2 3 8
168. Bruijn 1989 1log Kow A9 6 4 11 20EME fF FEB OLDE QSAR LFER LTFER LFER UV QSAR
169. i cee gaa eR oe F APES 1 v A9 7 1 9 2 MO
170. A4 8 7 1 ZERRRORODPLBE A4 8 7 1 1 a b c 2 tF bund MOK AFO CHIT B WAKO EM Z EIEII B fe IKEIKE fi DIEE Z Jo SB ASMODHEOD BR NG EPFON amp LAURE 2 HEH APB SX CHS 3 ACM PBS TMM EDE 411 A4 3 7 1 2 a b c A4 8 7 2 MERHAT SDS 9
171. DFADKE QA ean ee eae a HAKOR CSTEE 1999 700 MR 1 PAYA alae th Bu DER 6 N A9 5 3 5 2 A9 5 3 5 3 La
172. j BE 9 JE EF E AS BA European Commission 1996 E PAT SEC a log AA OT E BCF Kow
173. A5 1 3 HAF A5 1 4
174. CE EEN GHS Call Fa 1 2 1 4 333 A3 3 3 A3 3 3 1 if H
175. log 1log K QSAR E QSAR 4 1 BCF E BCF Bed AZIA E 505 A9 6 4 10 2 log Kw 5 5
176. 361 2 15 KR a B H241 si gt R CEA P210 P411 P235 P501 KIERRE EO b O DL I LAK Di C P220 P410 P420 P234 P280
177. P411 C P420 350 2 8 K C H242 D H242 E ee H242 AAT F H242 P210 P370 P378 P403 P235 P501 BUA TEIRAIRIBO DO OL DARA POR
178. A9 1 4 a 1 2 Oo ae ee ee
179. A3 2 2 3 A3 2 1 A3 2 2 A3 2 3 A3 2 4 A3 2 5 A3 2 3 A3 2 3 1 5 1 2 3 Hel GHS 307 4 5 A8 2 3 2 2
180. A4 3 9 9 A4 3 9 1 A4 3 9 2 a b c d e f g Pe arene A4 8 9 8
181. 2 1 3 n Kow EU Kow J ya A gt E n as QSAR 2 2 RIZTLS Kow BAED Z ODRA E 2 2 1 K HPLC 2 OECD 107 1995 OECD 117 1983 EEC A 8 1992 EPA OTS 1982 EPA FIFRA 1982 ASTM 1993
182. pH A10 5 1 9 11 a 11 5cm 200rp m tk PVC 8mm K 350mm 40mm 15mm 2 b 1 0 3 01 100rp m kK
183. Ey pH 7 A10 5 4 8 8 5mg l 709 6 0mg A10 5 4 4 A10
184. A9 7 2 2 3 A ere a A BLM 1 4 bl Aas Santore Di Toro 1999 OECD 2000 A MINTEQ Brown CHESS Santore Driscoll 1995 pH DOC 3 1 BL
185. ym S P370 P378 KBY ADP EMKACEGE 352 2 10 1 H250 1 P210 P335 P334 P422 DOR P222 P280
186. HY FE 4 ECs ETC H GLP a ROE EK V JOM 2 E 1
187. THIRD CH 0 RR IHOR REIN CHS FOU LDARENKE 1 E BRID L GE Cso 1 CeO AK L E Cs0 L FE L E Cs0 APE TE i 8
188. 3 3 5 OECD 1 OECD 302B 1 SC ARENDS LORIE E Rie EE eR 4 519 1 EK E E MITI II 302C MITI I 301C 3 UT DARE IMA OECD Zahn Wellens OECD 3 4 KZ IzLl g RR 3 41 ISO DS14592
189. WDA A TE AIRED BEARD A9 4 9 4 7 a iN D att ul b
190. PO ee ee ee J A A H O RA FET 2 15 2 15 4 1 NNER EROPEILALU Jo A2 16 2 16 55C 1 6 25mm 277 A2 17 3 1 era 1 LD 5mg kg LDso lt 50mg kg
191. log Kow EYE A9 5 3 4 A v NTa AWA A9 5 3 5 ZRIENE TERI A9 5 3 5 1 JH Ho ae European Commission 1996 E E log Kow QSAR eee nes
192. 490 A9 4 3 2 PADME A9 4 3 2 1 ee eee A9 4 3 2 2 2 100mgl
193. LEBT log Kow A9 5 4 FET SEF 2LRBLOUF 2ORM A9 5 4 1 2 975 BCF BCF 500 500 BCF BCF
194. RAE RE COD F E IDS DAA A9 4 2 4 1 4 1 4 1 2 11 3 a b A9 4 2 4 2 4 1 4 1 2 11 3 c 1n2 0 043 16 A9 4 2 4 3 AE AY fie k gt n0 3 In1 28 0 043 day
195. d e WSF WAF 2 A9 3 5 8
196. ee 2 HH A TUT A9 3 A9 2 6 3 NN Z ie Ba o A9 3 6 2 3 3 an
197. ym S o P337 P313 381 3 3 ZL 2B H320 P264 2 P305 P351 P338 kK CRA o P337 P313 E 382
198. Dee A4 3 12 6 x 7 418 A4 3 12 5 EBREHE 4 Kow BCF A4 8 12 6 BPOBHLE BRO H 1 Koc Kow 295 Pill CXS iz E
199. FEIN WB TE l OECD 2 E 48 96 3 202 Part 2 US EPA OPPTS 850 1350 1 21
200. 7 pH 5 L ER a 2 3 1 10 100mgl A10 5 2 3 1mg l OU pH 5 5 6 pH 28 A10 5 1 9 6 pH 7 gt EL 1 HNO
201. d GHS GHS ii e 453 3 1 2 XXXXXXXXXXXXXXXXXXXX XXXXXXXX
202. A9 5 5 5 a BCF O BCF2500 ZOYAITLEDMRMO THEIL BS Gi BCF lt 500 2ZOMAIVLEMRMO THEIL b BCF log K Gi log Kw 24 ZOMAITLSEDRMO THEE BS Gi log Kw lt 4 COYAIMLEDIRMO THEIL c BCF E gt log Kow log Kow i ii A9 6 QSAR DRH A9 6 1 E A9 6 1 1 E FE E 1986 Meyer Lipnick 1989a 3A H A
203. HAS 9 E A9 5 2 3 9 4 BCF 1000 10 OT OECD 305 1996 BCF BCF 500 BCF BCF A9 5 2 4 2A LP L K DEE Kow A9 5 2 4 1 Kow K
204. BREW bat FT v 7 ERG 2004 sail GHS o E UCSC 1 CNS OR ANSI A8 3 2
205. 10x 1 2 3 OF 10 b Aner HH 3 3 3 3 2 3 3 4 280 A219 3 3 1 YEROURRT X DB BEDRA a b 21 3 De era NN d 2 11 5 pH e ash in vitro O G 1
206. P280 P303 P361 P353 RE ERIE P363 P304 P340 P310 P321 FR REP URAH FALE BIT BIVET B lf LOVEFEA P305 P351 P338 377
207. A4 3 A4 2 5 2 A4 2 4 2 SDS SDS A4 3 16 A4 2 6 ST A4 8 SDS SDS GHS A4 3 1 1B
208. GHS A5 2 2 8 A5 2 2 4 27 S
209. L E Cs0 EE L E Cso A9 7 5 1 Nosr ARN YES 24 e o a L R Cso ORULE G2 ORAH 7 NO YES YES L EDCso NE ee 1 NO YES 1 a L E Cso 5 A 0 2 28 NO A NOEC 2
210. Lipnick 1986 A9 6 4 10 AMBRE BCF A9 6 4 10 1 BCF 1 H J EER 1og Kow Overton log Kow Kowx6 DH E
211. a 80 A9 3 5 6
212. Ping a ean he ene edd a b A9 1 2
213. pi S KEBY XZ EIGKE BC BGE 360 2 15 a A H240 w ris P210 P411 P235 P501 BVA TEERAIRIEO DO OL J AAKI DR P220 P284 P280 ym S 5C P410 P420
214. 349 2 8 K Le B H241 R P210 P370 P378 P403 P235 P501 BVA TERAI REO DOOL F REAR P220 P284 P280 pi S KEYRI EIGKE EL BEGE P370 P380 P375
215. 369 3 1 B 3 H311 T SL AE P280 P302 P352 P405 P501 P312 P322 FENOUTIAD E 9 RUE DL BTL P361 P363 wits 370 3 1 B
216. GRSAMP RID ADR gt EJK af N BE Ach A 2 3 5 A n T lt Z Er Se Van oa A9 2 2 ABRABLUAAAE A9 2 3 R A9 2 3 1 HEERE ee Fat HIF IC Ko CRESS AM
217. HI W Fee i 462 A8 5 Patty F Ed 1994 Industrial Hygiene and Toxicology 4tn Ed pxxxx xx New York Wiley Interscience Smyth H F Carpenter C P Weil C S and Pozzani U S 1954 Range finding toxicity data Arch Ind Hyg Occup Med Fasey Headrick Silk and Sundquist 1987 Acute 9 day and 13 week vapour inhalation studies on Globalene Hazexyl Systemol Fundamental and Applied Toxicology Wyeth G
218. A9 5 2 8 RME BCF A9 5 2 3 1 BCF BCF A9 5 2 8 2 OECD OECD 305 1996 BCF A9 5 2 3 3 K K A9 5 2 3 4 Ai 7 r ar Ke IRRE RRT J Uhh GLP 2 A9 5 2 3 5
219. LE C L Cso 1 1 ia 2 pi 3 28 1 28 28 eH 2 4 ee hat 4 HH x 2 K FAH L E C
220. P372 P240 KRAAD if ENTER Cb GE P250 Es ROERE E E LAME EITA ET A LER P280 1 48 HEBLOCOMAD DO LEKI DBE P373 P374 145 FHRBLOCORDDP REKREO ity a 338 2 1 ZL 1 5 H205 P210 P370 P380 P401 P501 BKIK EOD DO ODE IRAK POR
221. 2 8 BAT AB pago P375 P371 2 13 1 pag 2 14 1 LEs P375 326 A3 2 4 1 2 3 4 5 P401 2 1 aul 1 1 1 2 1 3 1 4 1 5 P402 2 12 1 2 3 P403 2 2 1 2 2 4 1 2 5 2 6 H 1 2 3 4 2 8 A B
222. 3 E SDS SDS GHS SDS
223. log Kw pH 1 o AUTOLOGP og Kow gt 5 European Commission 1996 2 3 5 SPARC SPARC EPA S8SPARC BOR HIS b amp o gt E SPARC QSAR KOWWIN LOGP log Kow vV EPA CAS
224. EJE E E E A9 5 3 2 8 BCE Kov DZ RODNE BCF A9 5 8 8 BAREO WAP L ORAWA 0 S
225. pees B 435 A6 1 10 3 9 BORIS LEE GHS
226. Dill A9 6 4 4 EPA ly SIDS E IUR ERY Cie US EPA 1999 A9 6 4 6 oe SAR A9 6 4
227. x 1 oe Oe G JE GHS GHS 100 Gi Pete Gii E GHS OR JER iv KOR GHS v c 5 10 d
228. Nyholm Torang 1999 ASTM E 1279 89 95 OPPTS 835 3170 3 4 2 a b 1 100z g l 3 4 3 3 4 4
229. 1 H310 2 H310 P262 P302 P350 P405 P501 P264 P270 P280 P310 P322 Fa FER OVERDO E F RRA BLES P361 Ym S Bb TRTOBRSNERBEMC L P363
230. 5 A3 2 3 6 5 P241 Zk Ik WRPERA CI BCA EZRBEET SGA DAMHNA A3 2 3 7 GHS Pe Ee CCS P305 P351 P338
231. 1 YARBLURART 4 Ob BADRA 1 40 14 mmz2s 2 BAYOR 2BAFCELV GE 3 10 3 2 3 DLE ORFMABAASNAVGE RORA 2 a 2 10 40C 14mm2s az pe b 2 10 40C 14mm2 s 291 A2 28 a 4 1
232. A4 3 11 5 A4 3 11 1 A4 3 11 6 A4 1 2 3 A4 3 11 7 TIBIE OD D SREB ORR sft A4 3 11 8 QE EFIR E DEH FIIR HE ES SHER A EIRA ZORNE ILE O BIA DICM TS A RR BEE SE 7 ERE RRS A
233. Nar A4 3 14 3 HXFFOTRIEZ FX A4 8 14 4 HATEAN FER A4 3 14 5 RHA EHE IMDG code ADR RID ADN A4 3 14 6 ZAZOE ODHT
234. QSAR QSAR f Fe A9 6 AIZ E SD wel ED QSAR Ik HY 3 E A9 3 4 HMDA A9 3 4 1 A9 3 4 2 A9 3 4 3 Lld BH TE JE Hes EFE lt E
235. 290 A2 27 3 10 pala 1 a b 40 C CHE 20 5 mm2s 2 BARBOR 2BAFCERLV GE 3 10 3 2 3 OR EORR HENRO RORA 1 a 1 10 40C F 20 5mm27s 1 10 40C 20 5mm2s
236. 3 4 1 1A 1B ager po 2 12 1 2 3 P232 sk 2 11 1 2 P410 316 K A3 2 3 1 2 3 4 5 P301 3 1 1 2 3 4 3 2 1A 1B 1C E 3 10 1 2 P302 2 9 1 8 1 1 2 3 4 BRE 3 2 2 3 4 1 1A 1B P303 RE ERIS 2 6 1 2 3 3 2 1A 1B 1C P304
237. Ce BEL INNS pH pH e CEH 10 eC REE pH pH A9 7 2 1 2 8 509 E
238. ERYQOR 2 BAF CELV GE OREO TEM 3 8 3 3 OLE OFM OG ARGU GES DED AE GEA WILK 2 a 1 10 3 8 3 4 3 8 2 3 BFR b O 1 3 8 3 4 3 8 2 4 ii 10 3 8 3 4 3 8 2 3 a b pe ye GOERE
239. 3 8 1 hOB L P BY 2 MIOF 2BAECE I BA OED 3 8 3 3 3 DRE ORD SAU BE 1 a eects e Re aie 1 RN a 1 0 3 8 3 4 3 8 2 1 b 10 3 8 3 4 3 8 2 2 WARLOMRT 2Y ODS HAD 3 8 20 7 3 8 1 2
240. A4 8 6 3 F CUD E MEROE E OHRA A4 3 6 3 1 a 2 2 5 A4 3 6 3 2 a b c d e f A4 3 6 3 3 ci A4 3 7 7
241. K EAR WS ya Hl 0 H E LCs pare 0 01mg l A Grom aie 1 0mg 1 E 2 ee pie X
242. A9 4 3 4 REPRE A9 4 3 5 ZV L 7RHRCOPET SIGE A9 4 3 5 1 1
243. pH 469 i O 3 A9 1 11 1 HRT A9 3
244. jo aE P210 P306 P360 P501 P220 P221 P280 pi S P283 P371 P380 P375 P370 P378 KEBY XZ EIGKE RC BGE
245. ASTM E 1196 92 ASTM E 1279 89 95 Standard test method for biodegradation by a shake flask die away method ASTM E 1625 94 Standard test method for determining biodegradability of organic chemicals in semi continuous activated sludge SCAS EC C 4 A to F Determination of ready degradability Directive 67 548 EEC Annex V 1992 EC C 5 Degradation biochemical oxygen demand Directive 67 548 EEC Annex V 1992 EC C 7 Degradation abiotic degradation hydrolysis as a function of pH Directive 67 548 EEC Annex V 1992 EC C 9 Biodegradation Zahn Wellens test Directive 67 548 EEC Annex V 1988 EC C 10 Biodegradation Activated sludge simulation tests Directive 67 548 EEC Annex V 1998 EC C 11 Biodegradation Activated sludge respiration inhibition test Directive 67 548 EEC Annex V 1988 EC C 12 Biodegradation Modified SCAS test Directive 67 548 EEC Annex V 1998 ISO 9408 1991 Water quality Evaluation in an aqueous medium of the ultimate biodegradability of organic compounds Method by determining the oxygen demand in a closed respirometer ISO 9439 1990 Water quality Evaluation in an aqueous medium of the ultimate biodegradability of organic compounds Method by analysis of released carbon dioxide ISO 9509 1996 Water quality Method for assessing the inhibition of nutrification of activated
246. BERIOFS 2 BAF CELV GES 3 5 3 2 B H ORE DOIRADA SNE GE 2 1 0 2 u fam A as RISD b ORDA ETAO L 286 A2 23 3 6 RA 1 BARL ORRAT Y Ob BIE 3 6 2 a b 1A ERYQOr Z2RBAF CELVG 1B E cite 3 6 3 2 A AEN gt n ai 3 OR EORR SNAV GE S Pe eee
247. e f BCF g log Kow A9 1 10 472 A9 2 4 2 n Er TEP 1mg l 9 2 4 3
248. Lemna 221 US EPA 850 4400 KA E ECso Lemna gibba Lemna minor 1 A9 3 3 KEBHOBS QSAR FIED ED Aah HH EEM Rand 1996 A9 3 3 1 A9 3 3 1 1 LN LE LE HO TJ FE AVE FTA 1 EE 50 4 A9 3 3 1 2 ba FF 3 FA A9 3 3 2 BMEEIE A9 3 3 2 1
249. 387 3 7 B ZL CEM PEE DAZ L H362 P201 P308 P313 P260 PEJA TULA ZNB VP DK h ORTF KAT EDD LNMAV GE P263 P264 2 P270 RE ECIIREOMSERS OBS 388 3 8 B 1 H370 lt lt gt gt lt gt lt gt 8 LDOUULT SCORELESS Olia LE ANT S lt lt gt gt CIE MO
250. 0 OO le 1 4 10 5 2 d 1 4 10 5 2 a 1 4 10 5 2 b 1 4 10 5 2 c 1 4 10 5 2 e EAIEJLO ROBE BEESTE o TITI RERRHZ GHS 449 Bl 4 2 200 1 4 10 5 2 d BFR 2 a 1 4 10 5 2 b 1 4 10 5 2 c 1 4 10 5 2 e a GHS ZNIE EGR AOMEIKET SME EFAA ICED B IIKRO MUB L ORRIRA PURINA CEPT 3 EBCE S 450 5 1 2 1 4 10 5 2 a 1 4 10 5 2 1 4 10 5 2 c
251. 2 TE Et lage L H401 3 PEE TAZE L H402 P273 P501 BEL MELIIAE 396 4 1 1 H410 2 TE lak a L H411 P273 P391 P501 LEE ZMELIIL 397 4 1
252. 3 1 1 2 3 P310 3 10 1 2 eg 3 1 4 Ps12 oa 3 2 1A 1B 1C P330 P331 a 2 9 1 P334 Lt CHE 2 amp o 323 1 2 3 4 5 Pn 3 1 1 2 P350 P302 8 1 3 4 P352 3 2 3 2 3 4 1 1A 1B se 2 6 1 2 3 p361
253. 2 BCE J Ay eM A9 7 1 RR JAD L Lu 510 Cai HIE SAV NR oes UT BCF BCF ER BCF pon BO YA CRU GE c
254. Seer S Er a b c d PPE A4 3 8 3 3 PPE
255. 2 16 1 P407 2 11 12 P410 2 3 1 2 2 5 2 11 1 2 2 15 A B C D E F 328 1 2 3 4 5 P411 0C 2 8 A B C D E F 2 15 A B C D E F P412 50 C 2 3 1 2 P413 k
256. Nae AE b E j E 1H h a A9 7 1 5 A9 7 1 6 A9 7 4 EDERE A9 7 4 1 A9 7 4 2
257. BLO BEE pH MEA Bee LA h 414 i Q k 1 m n o n p J PRE Ti BE q SDS SDS A4 3 10 10 A4 3 10 1 ACUTE A4 3 10 1 1
258. SDS SDS ee Ae Do A4 2 3 SDS OFF x0 NOY Ss YB
259. WW 553 A10 5 2 LAR HUY A10 5 2 1 d a b c d ec g A10 5 2 2 OZ pH HORE A10 2 3 2
260. i A8 1 2 4 1 4 10 5 3 8 2 LE A3 1 1 GHS 1 2 3 4 H200 BREAKS 2 1 H201 2 1
261. A4 2 4 8 A4 8 2 1 AOR RILEROORE A4 3 2 1 1 A4 3 2 1 2 GHS OF 2 3 4 1 A4 3 2 2 ERBAeS GHS F NILAR A4 3 2 2 1 A4 3 2 2 2 A4 3 2 8 MRE LUCABANRU COMODERA Blt
262. Hoek EHI fick AE HEHE 5 2 8 oo ees Eg NE Ns 7x KERT BAAR 504 E SAR S
263. 2 6 1 2 3 4 z z SS o p235 BS Ce 2 8 A B C D E F P410 2 5 2 aa gt p403 e P410 509C 1 2 a P412 2 3 P411 9C 2 15 AB C D E E gt x p235 330 A3 2 5 1 2 3 4 5 P501 SHA 2 1 1 1 1 2 1 3 1 4 1 5 2 6 H 1 2 3 4 2 8 A B C D E F
264. b c A9 3 5 7
265. 1 1A 1B H317 e P261 P302 P352 P501 AZJA P333 P313 P272 P280 a S BEJTA ET A P321 Fa REPRE E CALPE DIET Si av P363 384 3 5
266. P210 P370 P378 P403 P235 P501 BVA TERAIRIEO SO ODL I REAR DOR P220 P234 P280 ym S KEBY XZ EIGKE BC BGE P370 P380 P375 P411 C P420
267. a G 0 1 3 4 5 Gi 1 0 b Gi 0 1 3 4 5 Gi 0 2 1 ie Ke SHUR T 2 DOD B LEG YORE 1A kl _ 2 AYO BAF CELLU GA OREORE 3 4 3 2 Bebe nip AOS BEIT 3 DROIT IAL ED oo 1A AS tI REWE amp ay a 0 1 b 0 1 1 ARO MRT Z ODDA DHA ee 1B d Ae 2 BAWOF FIFE CER BA VRE
268. gt RTE COT BARE BIC AIVS OBO CLR J AEC ko VA 10 L E Cs COE ko Rnt LTES ET
269. 1 H330 2 H330 P260 P304 P340 P403 P233 P501 Hm RA BL EERE IEA XO BIE EPEFE tE CH SBE P310 P271 P405 P320 P284 BBB KE OMBHAORGRLELGR 373
270. E OAEL 25 1 ADD BHESANSACHAD RE ZIE au ante oa St faces A5 2 2 8 B lt
271. a b c 3 3 3 70 20 20 OECD 3 3 4
272. 1 ay a A9 2 4 3 1mg 1 oe 4 EME Ze AO H aan A9 2 6 F Z ORE A9 2 6 1 2 FE E ENE Fo ZIMA
273. DS YR fF I fle L E C50 Di 1 2 28 H 28 NOEC NOEC 3 4 NO 515 516 1 Do N 2 2 1 9 I
274. E 4 E 2 L E Cs0 2 pH HF X BUI XY LCR 10 OECD 1998
275. I HEREDO R TCH o Ag E ERL ee Ae a CELY TH R WEOE M E hh 2 3 2 P Wofford 1981 3 f fee A gt log Kov
276. b SDS c SDS ME SDS I XBEBLELOGE Ch RBOI SR SEERKAUZ GOS ERTED 1 CYRUS ABER KET OB VUEE SNK FLORETS SQLS SEL h Y A NBEBLE VD 2 Kh yDRVABRIL CEMA TRYEUILAT ER h Vv PHKNVARIIEW 13 Ry FAR ARANI IFZ OSPR ELOIEDRE LIAR L OGRE OV COFMOD WPA S AED FREZITYT S EO y FUE ARZWEV 421 422 5 424 A5 1 FF 5 A5 1 1 Bee ORR a ae
277. bd RA ahah ee Shins OAS FE FL Hansch E f E Lipnick 1989b 501 A9 6 2 ABHEOMNHFMLE TERE LORE A9 6 2 1 ade TEM E AR TT og Kow amp log C D QSAR Hipnick 1995 A9 6 2 2 4 E JE FY RB etm kere 3 E
278. 480 A9 3 5 4 L E Cso 1mg7l 1 1 1mg7l 1mg l A9 8 5 5
279. QSAR HYDROWIN 1 67 Syracuse Research Corporation QSAR EU 115 Niemel 2000 A9 4 2 4 14 2 QSAR BIOWIN 38 67 Syracuse Research Corporation 0 5 OECD 1994 Pedersen 1995
280. 1 3 1 1 1 2 1 8 247 1 2 ETER O RX IZ my Uae EFH ANZBDOEL VUE amp ERE ET VLBA CIE 1 2 ETER DRX IZ BIT BE ET ATR RTRT 248 1 Re ul Q
281. 1 1 1 2 1 3 1 4 1 5 ITAI ET 5 flaki HARV m 312 gt 1 2 3 4 5 P251 2 3 1 2 P260 3 1 1 2 2 i TERMS MERN 38 r MEEME He REP BT R 9 gt 3 9 1 2 3 2 1A 1B 1C oe EFRALZY SE VE ay HAS SE vR LOHR 2 Gee _emmicmA and BIEL DY 0522
282. HPLC 1log K 0 6 HPLC Log Kow USEPA 1985 Kow QSAR Kow A9 5 2 4 3 QSAR log Kew Kor Kow QSAR 4 PC CLOGP LOGKOW KOWWIN AUTOLOGP SPARC CLOGP LOGKOW AUTOLOGP S
283. 14 10 28 10 10 28
284. 3 2 5 2 tee H315 P264 P302 P352 P280 4 P321 FR READE FALE BUT OTE T 6 if J LUT HAH P332 P313 P362 378 3 2 2 3 H316 P332 P313
285. 3 7 P202 KRH 2 1 Ds 3 5 1A 1B 2 3 6 1A 1B 2 3 7 2 1A 1B 2 309 1 2 3 4 5 P210 2 1 _ 1 1 1 2 1 3 1 4 1 5 REAA E Lore BT i 2 2 1 2 2 3 1 2 2 6 1 2 3 2 7 1 2 2 8 A B C D E F 4 2 9 1 5 2 10 1 2 15 A B C D E F 2 6
286. A4 2 3 1 SDS 16 1 5 3 2 1 A4 2 3 2 SDS UE eA ees ERA EEO BERN eae LOTH E ET SDS A4 2 4 SDS A4 2 4 1 SDS 4 A4 2 4 2 4 3 1 SDS
287. T E A AOR E ER De ELD AE k REL 534 9 V 1 a EC guidelines Comission Regulation EC No 440 2008 of 30 May 2008 laying down test meshods pursuant to Regulation EC No 1907 2006 of the European Parliament and of the Council on the Registration Evaluation Authorisation and Restriction of Chemicals REACH b ISO guidelines ISO http www iso ch c OECD guidelines for the testing of
288. yo in vitro oa mmm mos zm 0 3 15 mg 5 i S9 0 08 0 4 A mg ml 89 ICHO SCE CHO 461 A8 4 8 ATER Y SF A8 4 9 J EHE
289. 442 E A6 5 12 8 A6 5 13 ZEF A6 5 14 RE ete
290. A9 2 4 5 Aaah ep SAD EE aaa Ly log Kov logKy 24 1 L log K BCF HAF BCF 2500
291. APU AT Ald KAA E 1 a A9 2 3 2 2 2
292. gt ES 3 2 3 OECD 3 2 4 BODs 5 3 2 5 gt 709 3 8 AEMEDREE 3 3 1 of K gt 60 BA 1 EUC 5 4 OPCD 3806 oS FR SO PO 1 lt ee ORBCD
293. 1og Kow pH log Kow 0 5 European Commission 1996 part II Niemela 1993 European Commission 1996 3 PC 2 3 2 CLOGP Daylight Chemical Information Systems 1995 T AE AL log K log Kow 0 9 log Kow n 501 log Kw OECD 1993
294. BT QSAR E SPARC log Kw A9 6 4 9 2 log K pKa
295. COLD RM QSAR E EZES 1 E F PS g X log 1990 1b ORE FE TEH K A9 6 8 QSAR EFN ORUE A9 6 3 1 HE amp ZS One 1 QSAR E 1 ASIC eA FA E
296. TERO XI BIT SIDE PURI L O HERE 2 8 2 8 4 1 ETE RA OMELET SHE PRISLO HEZ TT 2 8 2 8 4 1 TEERADA IC BIT SHG PRIL ee DEBRA BIER INE MERE LP NNEREF OFF 2 8 2 8 4 1 EVIL ZL VY ft 213 gt A2 9 2 9 o 52 2 5 A2 10 2 10 mes pm s 5
297. n 800 r2 0 96 sd 0 387 SPARC log K EPA Rekker amp De Kort n 1054 r2 0 99 1979 n 20 r2 0 917 sd 0 53 me 0 40 Niemi 1992 MCI n 2039 r2 0 77 n 2039 r2 0 49 Klopman 1994 98 n 1663 r2 0 928 sd 0 3817 Suzuki amp Kudo 424 n 1686 me 0 35 1990 n 221 me 0 49 Ghose 1988 110 n 830 r2 0 93 sd 0 47 ATOMLOGP n 125 r2 0 87 sd 0 52 Bodor amp Huang n 302 r2 0 96 sd 0 31 me 0 24 1992 n 128 sd 0 38 Broto 5 1984 110 n 1868 me
298. DRZ AITIDH g x A Si amp AV BCE sca CD E BCF F Seat ea eee HV OECD 305 E 6 BCF ee BCF Ufa Fi BCF
299. c d e f SDS 7 BHI RR BLORE HEE SSR 413 A4 8 8 3 HAARBK PPE 2LOMA RBAE A4 3 8 3 1 PPE SDS 5 A4 3 8 3 2
300. a 2 3 8 10 b 2 4 10 c 2 5 6 7 10 d 2 11 e 9 2 10 H TV 3 4 5 7 8 A oa 2 10 438 4 K A6 2 ARAY 2 6 amp 10
301. 2 7 x 1 H228 2 H228 a P210 P370 P378 ENAKTEIERKIIO DO OL I REAR DOR P240 EU BURL ENE AL BT BE P241 EPUABERET E HIED b BHE P280 pi 9 KRY AP EWKEABBE 348 2 8 r2 A H240
302. LEH 3 1 2 8 A 1 E E T eet ae ae A BROOM ae HK SI Fe gt
303. 4 H312 e P280 P302 P352 P501 P312 P322 Fa FEN OLEPAD LI RRA DR BARGA P363 ioe 371 3 1 BL 5 H313 P312 372 3 1 B
304. 6 RC A4 3 3 1 4 ZCHAADHBMANTRY BEPOMFBAODE A4 3 3 2 BAD A4 8 3 2 1 GHS eee A4 3 3 2 2 a b YE FA A4 3 3 2 8 A4 3 3 1 ED
305. Al A9 1 3 a MNS DS Oe OR ORE See oe chronic aquatic toxicity A9 2
306. BCF BCF SS 1 A9 5 2 3 8 1 BCF A9 5 2 3 8 1 BCF ZS N BCF MSN N BC j i EE SA aE ERO o gt A9 5 2 8 8 2
307. 1 QSAR A9 6 A9 1 15 v A9 1 16 AS
308. HE RARA EYE E E FE DT ya I Z Y RIDAR 0 ORE TIRET ED Rh E log K 4 BCF lt 500 E E 1 254 a a L E Cso 1mg 1
309. OECD 1995 3 2 BEDE 3 2 1 OECD OECD 301A F EU C 4 OPPTS 885 8110 ISO 9408 9439 10707 3 2 2 a 2 100mg 1 b c 10 108 mL d 518 e 10 301C f g 25C 70 DOC
310. ig L E Cs0 H a NN o gt A9 3 5 8 AB TICHET SZ OMOZK a 2 Cx Case lee b w c AMES NOEC log Kow log Kw
311. DI a F e bK gt Sa 4 4 E A9 7 5 4 2 1mm 3 ME 613 E
312. GLP ISO ASTM GLP GLP EE 484 pe A9 3 6 2 2 Pedersen 5 1995 TEZE HIFR A9 8 6 2 3
313. pH OH WK E E pH 2 OECD FAL 111 pH OPPTS 835 2110 OPPTS 835 2130 PH 2 OECD 111 2 3 RT pH
314. 4 1 WC x BCF DOGE E HEZ Eo CS Comotto 1979 Wakabayashi 5 1987 Goodrich 1991 Toshima 5 1992 ADERE LZ VE JBFENA ITA ICHEM AMS ASEAN BCF f TAK DS SE H 496
315. 497 LOGKOW BHO BEE SIVCWS A9 5 1 A9 5 1 K QSAR log Kow CLOGP log Kw lt 0 C H N O P 8 log Kow gt 92 1og Kow LOGKOW 4 lt log K C H N 0 Si P Se Li Na K KOWWIN lt g gt Hg 1og Kow Pl AUTOLOGP log Kow gt 5 C H N 0 P 8 1og Kw AUTOLOGP
316. pH 10 mg l Bt IER IETS pH 28 a F pH L E Cso An AA A9 7 3 RREICBIS SBCA SM A9 7 3 1 A9 7 3 2 CE f a FI E E
317. 3 4 1 1A 1B H334 P261 P304 P341 P501 P285 P342 P311 383 3 4
318. K Y AD EIGKALBEE BAD 3 46 2 6 ZL 4 H227 P210 P370 P378 P403 P235 P501 P280 Ym S KEY RF EKIS AA BE 347
319. SEP WENY GHS By c d aia f g A E e h HIE SRR FEN W5 i G SDS Sai A4 3 11 2 A4 3 11 3 SDS A4 8 11 4 1
320. RRR IRBE OMERE RRREO
321. 24 3 10 100mg 28 555 15 7 20 Img l A10 5 4 BREF A10 5 4 1 20 23C 1 5C A10 5 4 2 A10 2 3 2 A10 5 1 6 pH pH pH 40 2 100mgl
322. 4 2 Ad 1 PADHA a teat 2 BADRA 0 1 296 3 298 3 1 ffi A8 1 1 FRX A3 1 1 1 A3 1 1 2 GHS A3 1 1 8
323. 3 E 4 QSAR 1 E os ite a Oe E 96 LC50 n ah lt WHIT La k TER
324. CiS 10 A9 7 1 5 4 1 Eo yj 4 E ox log Kow Ae X N04
325. OECD 107 1995 2 25C 4 gt a De Bruijn 5 1989 ESL EEE T E nm log Kow 4 5 Ko Control Act Test Guidelines USEPA 1985 529 2 3 log Kow REDE MOOD QSAR DH 49 6 QSAR PHI BB D E 2 3 1 Ko
326. 1SO6341 2 O 2um pH8 NaHCOs 65 7mg 1 KCl 5 75mg l CaCls 2HsO 294mg71 MgSO4 7HzO 123mg l pH pH A10 5 1 7 A10 5 1 4 _ 2 0mg l A10 5 1 5 v NaF 8mg 1 SrCls 6 H20 20mg l
327. a a aula eae re A H eee CLA T ET sel epee oe pee f ME H o
328. pH G G k 5 LOGQ A10 5 1 2 ACI 1 2 1 27 pH8 17 2 81 bol A10 5 1 8
329. 1 aC Oa Gatien E Ee ge eee 20 NN a TS S HF E a Amie c 499 E BCF BCF
330. 2 1 2 50cm 2 4 3 OPPTS 835 5270
331. 265 ETER BR ORE BIT BE ETNIE SATVIR 266 2 268 2 A2 1 2 1 LEER GO WE TS Mie PRBLEEM OOO 1 Ye ERO OWEIZLIT S E MBI LOWER OC 1 EET RDI RITZ HE PRI L WERE 1 2 1 ah N EERO tip Al AF S 1 8 WE RRT L OHE 1 ate DE MIE LOWELM 14 ERR Otc BIT 5 Me PRBE WERE
332. EE me KAIF AL IMO ED WADA E 1 H E Hah Ey WE Bos 4 1 BO 4 1 2 4 4 1 1 A Ey WE SER
333. TLipnick 1991b QSAR EE 3 ek QSAR A9 6 4 2
334. 3 2 1A 1B 1C RIE FEI RIELAI REI E PET 3 2 2 RIEFRERVET 3 lt 3 4 5 oa ee 3 3 1 Z ETTE H YE 8 3 2A 315 1 2 3 4 5 P281 2 1 3 5 1A 1B 2 3 6 1A 1B 2 3 7 1A 1B 2 P282 2 5 P283 2 18 1 2 14 1 P284 8 1 1 2 P285
335. 379 3 3 _ ee vy NA 1 H318 P280 ym P305 P351 P338 7K CRAIG o P310 E 380 3 3 SB 2A H319 e P264 P305 P351 P338 P280
336. A6 2 6 8 11 1 4 1 9 De alert K A6 2 6 9 o V A6 5 2 A6 3 HRT OO L
337. ECETOC 1998 QSAR A9 6 4 9 nn KAA Kow A9 6 4 9 1 log Kow CLOGP US EPA 1999 LOGKOW US EPA 2000a SPARC US EPA 2000b CLOGP LOGKOW SPARC EEF VOI
338. 3 10 B 1 H304 2 H305 P301 P310 P405 P501 P331 394 4 1 1 H400 P273 P391 P501 LEEZMELIIUE 395 4 1 B
339. 3 3 1 3 3 2A 2B P340 31 1 2 3 4 3 2 1A 1B 1C 3 3 8 3 3 8 P341 3 4 3 1 1A 1B P342 PI ARR EPE 3 4 1 1A 1B P350 3 1 1 2 P351 1A 1B 1C 3 3 1 2A 2B 1 2 3 4 5 P352 3 1 3 4 3 2 2 3 4 1 1A 1B P353 2 6 H 1 2 3
340. A10 7 A10 5 2 1 a b c d e f g h i Q H pH A10 2 3 2 A10 5 1 6 A10 5 1 8 A10 4 PR de SIRE ATEN pH 557 k 1 m n o p
341. A6 5 15 AREI GHS 1 1 443 444 7 GHS 446 7 GHS GHS 1 2 GHS OO QOL 2 CQ UNXXXX 2 1 4 10 5 2 d BFR 1 4 10 5 2 a O 1 4 10
342. K 5 1 YE BESS RDO Wre lz IF SME EPA ICES ORR 1 ee Wel 2 DRA DIKO E 249 1 2 3 4 ETER DR I BP SME EFL HARES vy See ETER DR I TF SbMG EJIL HATIRA ES VT 1 2 ESE OO Wh lZ AF TIRE gt EFNA MITE 2
343. Kow HF J Pj pet A F dk R o Ko Tolls 1998 Tolls 1998 Tolls 1998 LOGKOW log Kov log Kow Roberts 1989 1og Kow
344. k Sijm Linde 1995 Opperhuizen Sijm 1990 1 2 pH Opperhuizen 1985 Anliker 1988 Opperhuizen 1986 Clit AHH Gobas 1986 E z 1985 i E Sijm Linde 1995 ECETOC 1995
345. 2 1 4HADKES BRA ASE Peterson Kel 2 2 FSH 2 3 fH 2 3 1 j MO bi H A E
346. OECD 107 1995 OECD 117 1989 EEC A 8 1992 EPA OTS 1982 EPA FIFRA 1982 ASTM 1993 pH OECD log Kow 2 4 DR n RERS OECD log Kov D 8 2 K OECD Guideline 1998 n
347. REKTAL te Melia L WERE LL te Belin L ELRETERO OWA GT SMG EFI BEAL CVS BATE S UTVR EERO te CET SMG E FARA CL E 1 v Y ETILI FA 9 3077 3082 ETNA F A 9 1 2 8 4 i EERO tk CIT SME t a BERL esre W FEDS EFIT fife He ae E DE 35 7 DE E AELE TER Bia 7 L TER Bila 7e L TER Bila 7e L DA a ea mae z ERD AXI BIT BMG EFI HAJT GHE S NTORO ETILA F A 9 3077 3082 9
348. 1 1 1 2 1 3 ee 7 1 6 EH 3 7 6 4 CBO RI B A8 4 3 ARICXSS SEE ALGIES e LARUE 1 mI Er GHS 1 E BARKON w w FE
349. 0 100C 10 830 10 de Henau 1993 4 4 pH pH pH 6 8 5 pH
350. 1mg l A9 3 3 3 EJIE 4 PH RHR AE SER SIV CWS A9 3 3 4 RAB OFF EDTA EDTA
351. 3 H226 P210 P303 P361 P353 P403 P235 P501 BU ATEEAIEIELO DDOL I RBA POR P233 P240 PERIMEDE EAL IT GE BEB SERA ECKE IEF SUD IEE TESHA P241 P242 P243 P280 BRE P370 P378
352. I ON faa A6 2 8 1 12 A6 2 4 A6 1 1 GHS ZET 3 ERKI OO LADO E 2 Ch B EUR NEB ILO DEBRA EVE UB IEL YF 3 ERED 0 I FPR OV RKFOFRRHIF AI Lo CHB ENE 431 A6 2 5
353. P261 P304 P340 BECARI AIS ARRAS E OMALH P312 P271 375 5 ZL 3 2 B aa A a 1A 1C H314 ates P260 P301 P330 P331 P405 P501 PEAY PICEA SH I BIEL Y PSR ORF AS BATE DE LIA BE P264
354. 0 1 0 8 A6 5 10 Mie AG6 5 10 1 Ty a ARBORS OFPGRAB 2 b 2
355. log Kow 24 BCF lt 500 b L E Cso 1mg l A9 2 3 5 A9 3 A9 4 A9 5 A9 2 3 6 1mg l BCP 500 BCF log Kow 24 EME 0 ele E ate a ace 4 A9 2 3 7
356. 2 3 3 LOGKOW KOWWIN Syracuse Research Corporation 1 log Kow log Kow Tolls 1998 Hg Roberts 1989 C He NOO be ails CLOGP LAS 5 CLOGP 1E Si P Se Li Na K FA LOGKOW CLOGP PC version 3 32 EPA s d 0 58 n 7221 CLOGP P
357. 4 FIE Te NR AF REP ED 1ER ME 506 A9 7 A9 7 1 A9 7 1 1 iit TZR AREA T NE TIA Bt A9 7 1 2 A9 7 1 3 F A9 7 1 4 Ea 3 2 E ECHT 4B s g li
358. Tw 1 gt ETER D HIE TEMG EF HAN EARRARO 3 as yy JR 5 D 4 252 1 2 EEE ROO RMEIZ IF SAE EFN 4 1 2 8 ETER D I BIT SMG ETIA Al NM See 2 AY BABES KHE 253 1 2 3 TEER ODI S Y S LIS 5 EFNA ANC KB CRRO ES
359. 1 28 RHO ih 28 E tz 70 GN Q10 10 A9 4 2 4 4 ee
360. A6 3 8 BWG ORRWE PH ILHIAICEIT ZAF NIR A6 4 A6 4 1 XREN AG6 4 1 1 A6 2 an H
361. QSAR QSAR 3 500 Re MAE SBEAN BKORMISHWAS OMA CII Kow oo A QSAR Kov A9 5 5 4
362. c 35C d COz CH4 3 6 8 520 3 7 tBRLUEE PODM 3 7 1 OECD 304A OPPTS 835 3300 3 7 2
363. 2 a ee 7 275 A2 13 2 13 pestis 1 1 1 1 gt E 50 1 1 E E ETE u 1 1 kek erue mn ADEE 11 ORAMO TSF ER 1 nin RRO wet ab i 1
364. A8 4 5 2 KRIET LS elt A8 4 5 2 1 O v 460 A8 4 5 2 2 RA 0 43mg 72ppm E V gt 3 RAR AUREL CITY MAREE LS CO 13 GHS o RER NOEL mg F344 0 12 W oe ee 0 24 te 10 ROSY EA TARE
365. E a 9 A9 7 E gt Et MO RL HE L
366. OECD 1995 BIODEG Hansch Leo 1995 Meylan Howard 1995 Hilal 5 1994 Howard 5 1992 Boethling 5 1994 Howard Meylan 1992 Loonen 1999 Pederson 5 1995 Langenberg 5 1996 US EPA 1993 A9 6 4 12 4 SDV IBL ORICAT AEREE log K
367. WEBLOKRT Z Ob ACDA L Cs lt 1 mg l ZIT LE Cs0 96 LCso 48 ECsoLCso 72 96 ErCso 2 LERYOR 2BAF CELLU GER OFF ORM ZN 4 1 3 4 3 Si aa BE a he lai Cisse eee I 1 1 x M 2 25 M 4 1 3 5 5 5 1 b SN is 4 13 52 4 1 8 5 8 1 LCso 1mgI O 4 1 8 5 2 4 1 8 5 5 8 1 1 x M 25 4 BERTO J b 1AL LIZ OU CHA REI PRS LLU WE MIOGE FTC ARE AVY CAL x 1 MET ORR ae SECDHA E 1mgl lt L E Cso lt 10 mg l ee L B Cso 96 LCso 48 yan trae ECso LCso PA 72 96
368. in vitro ORTH d 7 sE OREORE _ EASE 2 3 4 T IN ul oR ge OF x i Hilly 3 2 3 2 2 2 LE MIOF 2 BAF T RORA ORE DRAZE 3 2 3 2 3 DLE OFM AHA ANZ GE a 2 i 1 1 5 Ait CHS Gi 2 10 G L 10x 1O R 2 10 O RHEE Se BLD Ch BBE DF 3
369. A10 5 A10 5 1 ABBA LHE A10 5 1 1 KICRT AAS LOREAL PROFILES b OCHS a A10 5 1 2 b SO6341 A10 5 1 3 c A10 5 1 4 d PEPR HL A10 5 1 5 ec 0 2um A10 5 1 7 0 3 20 C 23 COPA C 1 5 C cf g h 0 2pH
370. A9 5 A9 5 1 A9 5 1 1 OECD 1998 UD UARA E EREB E REIT S TA T ee DRBeASUCVS biomagnifcation ieee a E
371. ENREDO TEER OD BB IT SMEG EP AUTAR S NTAN N T p a pe gt 8 ta RSA P BRIS 5 BARS 727A EE ARE 1 2A 2B ERRORE FETE RO DWMIEIZ BIT DE ETNA ITRE SIV TVR 259 1 1A 1B EE Ronix BIT SG e ENAUT IRRE SUCRE 1 1A 1B FREER OD tpt BIT 3G e ETNICII E SITE 260 1A
372. BCF ee H One ats 1 2 BOF DEBRI E SMEDE ODITE 1 2 1 4 oe D ee Ly OECD OECD 305 1996 ASTM ASTM E 1022 94 OECD 305 1996 OECD 305A E 1981 ORCD 305 1996 ASTM E 1022 94 log K z gt 3 1 2 2 OECD 305 ASTM a b c d e f 1 2 3
373. E 2 JER H A9 4 1 2 4 1 8 C AY 1 o pH P DATOM wm a 1 A
374. SDS te A4 2 2 2 SDS 8SDS Sy 405 A4 2 2 3 A4 2 2 4 SDS SDS
375. Scow 1982 2 6 104 108 HI RIB AKA GIL 103 106 Scow 1982 2 7 2 AREA mgC L OECD 1995 amp 1mg 1
376. 1 pe Seats H kre WH ee a ah fi uy PE cay a re 3 ia Lu 3 H
377. P234 P280 363 2 16 1 H290 P234 P390 P406 364 3 1 B 1 H300 2 H300 P264 P301 P310 P405 P501
378. 2 5 A2 5 GER a 50 50C _ oy 50 2 a EIER 50 65C WER 65C b AS A 271 TE RAE a Sh m A2 6 2 6 lt 23
379. HNOs1 2 pH 1 A10 5 2 3 4 A10 5 2 3 5 a MRT OED DA FORDS 5 EESNS b lt c A10 5 3 FAROE Hl CHL CHA BAD FEES A10 5 8 1 ERZ V gt D RRS EESE EEMO A10 5 3 1 1 80 A10 5 3 1 2 24 Aah 1 HNOs TE MAR EBRBL OCCA A10 5 3 2 pH 100mg l
380. pi US EPA EC ICE S Q SAR OECD 1994 Pedersen 5 1995 3 8 2 MITI 1992 CO EMAL elas 304 AMICON EN SSN 2 MCL 162 MITI I 41 25 142 ee MTITI I 138 97
381. 456 8 A8 1 GHS RAAE ES RIR P 1 4 A8 2 1 1 EINECS EINECS IUPAC CAS No 999 99 9 EINECS No 222 222 2 eo me T Globalexy1 UNoxy ILOate Hi ba eg 457 A8 3 4 21 ENAR 2 2
382. Bett H EI Ceo SJ 28 E 3 MM 1 B A10 3
383. Do 4 BCF BCT A9 5 4 2 FFT S log Kow 1og K 4 4 log K QSAR log K A9 5 4 8 BROAD BCF log Kow 1og K log Kew
384. Gi 0x 1 2A 2B Na 10 b 2A amp 4 panels 38 2 3 8 3 3 4 B FR 282 A219 ARIES D AR LAE IIE GPMWTG 8 3 EBLE SEE pain y 1 BARUHRT YO BADE a b 7 K 3 3 2 2 3 3 3 2 2B 3 OR EORI SHAVES 2 a nest 2B i 1 1 3 1 Gi 2 10
385. j gt Tm zl A10 4 amp b c d ppm KE 550 H E e E gcm3 mg BET Ns g h G SDS
386. 3 2 3 4 E OPPTS 835 2110 2 4 2 4 HAE 1 OECD OECD 1997 517
387. 507 4 S515 Wi Game ee tis A FA hh 5 E A9 7 1 6 A9 7 1 7 l 4 1 H NT
388. E ay DR CEN lia RN f QSAR ete A9 6 4 8 2 QSAR v He
389. P370 P378 KRY RP EKA 359 2 14 2 H272 3 Whe He H272 P210 P370 P378 P501 P220 P221 Es Bye P280
390. SPARC log Kow gt 5 SPARC KOWWIN SPAROC QSAR CLOGP KOWWIN CLOGP AUTOLOGP log Kow SPARC a Niemel LEBHNZRY S407 log Kow M e MEME HRET 3 A EERE ITU log Kov DAZ 0 LL GLLE COBRKOBKRILADYO log Kwl oT FCOPRFAPADIEMIZ PIT E E EMER LF n 501 r 0 967 TemaNord 1995 581 b log Kow HEEM 2 FRM LU CPR TH y hL 18058 MEO ChAT LE EFA Syracuse Research Corporation 1999 LOGKOW i log Kow 4 25 8 DHANI amp BLE GWUZ OV CHE CHS EFM SAT Do A9 5 3 BOF BEO Kow ICRI Ul TRIIR RO BERF FA A9 5 3 1 BCF 3 3
391. 2 2 1 2 2
392. By eR LU lt 23 HHA gt 35C Z230 gt 60C lt 93C ee a b lt 45 gt 2 2 mm lt 5 9 ain a 4 b lt a gt 2 2mm gt 5 y 10 272 A2 8 2 8 DMEM OWEIAIT EEE BRIE L OF ag aC HERE 2 8 2 8 4 1 eS REER DIMZ BIT SHE PARRE O HEZE 2 8 2 8 4 1
393. P380 336 2 1 1 1 H201 LZ A 1 2 H202 a 1 3 H203 P210 P370 P380 P401 P501 PUKEKO bD OL I LAME P372 P230
394. QSAR He fe 1 GLP GLP H E ice E 1 a RORY
395. eee DY AZOV A9 7 A9 5 1 3 Ww j E an WCK FRSE 2S BA Vaated PRERE i LOA BE 9 IV 9 A9 5 2 AMBRE I DRR A9 5 2 1
396. log Kw QSAR QSAR SIL QSAR Kow n Kw EEC A 8 1992 OECD 117 1989 pK pK pH A9 5 2 4 2 Kow Kow HPLC
397. 1 2 3 A4 8 15 1 R4RUICRALAE ERP LORICH T DH A4 8 16 16 SDS SDS SDS 1 15 a SDS SDS SDS
398. 4 NOEC ECx mg l A9 3 3 2 4 Lemna a b c LEC NORC
399. OPPTS 835 2110 Hydrolysis as a function of pH OPPTS 835 2130 Hydrolysis as a function of pH and temperature OPPTS 835 2210 Direct photolysis rate in water by sunlight OPPTS 835 3110 Ready biodegradability OPPTS 835 3170 Shake flask die away test OPPTS 835 3180 Sediment water microcosm biodegradability test OPPTS 835 3200 Zahn Wellens EMPA test OPPTS 835 3210 Modified SCAS test 637 OPPTS 835 3300 Soil biodegradation OPPTS 835 3400 Anaerobic biodegradability of organic chemicals OPPTS 835 5270 Indirect photolysis screening test Sunlight photolysis in waters containing dissolved humic substances 4 ASTM 1993 ASTM Standards on Aquatic Toxicology and Hazard Evaluation Sponsored by ASTM Committee E 47 on Biological Effects and Environmental Fate American Society for Testing and Materials 1916 Race Street Philadelphia PA 19103 ASTM PCN 03 547093 16 ISBN 0 8032 1778 7 ASTM E 1022 94 1997 Standard Guide for Conducting Bioconcentration Tests with Fishes and Saltwater Bivalve Molluscs American Society for Testing and Materials EC 1992 EC A 8 Partition coefficient Annex V Directive 67 548 EEC Methods for determination of physico chemical properties toxicity and ecotoxicity EC 1998 EC C 13 Bioconcentration Flow through Fish Test EPA OTS 1982 Guidelines and support documents
400. 1 14 RHENT McKim Goeden 1982 E BCF Opperhuizen Schrap 1987 Sijm 5 1993 HH 1f 533 IC BU SOAK Cae E
401. 2 12 1 2 ee 3 3 2A 2B P313 a 3 4 1 1A 1B P311 nae 2 4 1 P376 325 1 2 3 4 5 P370 2 6 1 2 3 4 pare 2 7 1 2 2 8 BAT KEYI RP EKES HA A B C D E F 2 9 1 H 2 10 1 2 12 1 2 3 2 13 FF 1 2 3 2 14 1 2 3 P370 2 1 ech LA 1S AAs P870
402. 2 5 B wee H280 H280 ee H280 P410 P403 ar 344 2 5 PERMA ee ae H281 ESE P282 P336 P403 o P315 345 2 6 K 1 H224 2 H225
403. 2 7 1 2 H 2 8 KEY AZ EKSE A B C D E F 2 9 1 H 2 10 1 2 12 3 1 2 3 2 18 1 2 3 2 14 1 2 3 OZ 1 2 3 4 5 P380 2 1 BEEF 2 1 1 1 1 2 1 3 1 4 1 5 2 8 AB 2 18 1 2 14 1 P381 2 2 1 2 P390 2 16 1 P391 4 1 1 4 1 1 2 aoe
404. Hipnick E 1 HE log Kow FAY o WB hh AN E E E PEO IE A9 6 3 2 n E HE ER A9 6 3 3 QSAR
405. BCF ASTM E 1022 94 o mayan A9 5 2 3 7 log K 6 J Ay eM 495 E 2
406. RR GA A9 5 3 2 1 DoE 1996 ECETOC 1996 US EPA 1996 OECD OECD 2000 OECD E SA
407. 2 14 B 1 H271 P210 P306 P360 P501 P220 P221 EA P280 jm 9 P283 P371 P380 P375
408. 4 1 314 1 2 3 4 5 P280 2 1 PREM ETET D E 1 1 1 2 1 3 1 4 1 5 2 6 1 2 3 4 EIL TE T TETE 2 7 1 2 iets i a 2 8 AA A B C D E F 2 9 1 2 10 1 2 11 1 2 2 12 1 2 3 2 13 1 2 3 2 14 1 2 3 2 15 A B C D E F 3 1 1 2 3 4 bRIEFLIRBRKEVET D E
409. A9 6 3 QSAR A9 6 4 QSAR A9 7 A9 7 1 FF A9 7 2 A9 7 8 A9 7 4 DE A9 7 5 T IV V V BCF Ks 465 467 471 471 471 471 472 473 473 475 475 475 477 479 479 484 485 485 486 490 493 494 494 494 498 500 500 501 501 502 502 503 507 507 508 510 510 511 517 523 527 533 535 539 466 9 A9 1 FR A9 1 1
410. E A9 8 5 ARNEE A9 3 5 1 DoE 1996 ECETOC 1996 US EPA 1996 Fa 23 amp UCHE A9 3 5 2 1 Met LUC mine 1
411. GSLMs OECD 1 9 A9 7 AZAR OECD EU 5 11 A10 1 2 Em Efe 4 A10 1 3 a b BRAM A10 2 A10 2 1
412. H HPV HPV L JED 1990 2 800 HPV A9 6 4 5 SIDS By Sd e iar tg da es a
413. ISO 11348 301D BATHE PERABR IC HEMET AR 2 HM A9 4 3 5 5
414. P210 P377 P403 POR P381 340 2 2 aL 2 H221 P210 P377 P403 PUUKIRKKO SO DLI LAA POR P381 341 2 3 1 H2
415. 1 2 A6 4 2 A6 4 2 1 2 11 EME Ej A6 2 A6 4 2 2 Do x F nT 2 Bil
416. 8 Ha RE A3 3 3 2 3 A3 3 3 8 A3 8 3 4 GHS E Beak HE GHS P101 een
417. BBS 4 fine H 4 AS eee L B 4 3 E E HEA K 474
418. mee A6 4 2 3 A6 5 A6 5 1 GU CS OEIC 2 11 Sk FAA 2 8 10
419. 1 SN 289 A2 26 3 9 WARLUART Z OD SEE 3 9 2 o cane 3 9 1 BE T HEEWIOF 2 BAF CE LV GE RA poe ee TETES DRE ORME EN RV BA DREDD ORRELA ET gt LK TRS ee Le ea Ce Ome 1 ce ee i a 1 0 3 9 3 4
420. EX A9 7 1 LE Cs A9 7 5 1 2 NOEC A9 7 5 2 A9 7 5 2 1 3 LE Cgo Be a LE Cso 4 BNR D ZAHM B A9 7 5 2 2 A9 7 5 2 3 paces ene ED LE Cs X
421. 1 GREE 3 BLU GE 2 8 24 48 72 0 5 7 5 A8 4 4 ARR EMEA L OVP AES ELE H A8 4 5 FYE ALR BRIE L SFE AALE A8 4 5 1 HIRE L SEL GHS
422. 2 Fe 4 I HE TETE Fe PE EL E el F HE L 1 10ppm 1 Tom 1 50 RUE 50 F D 10 100ppm 10 100mg 100ppm 100mg 1 ZUG BE L TRE SMe ae I BED DRATARO D BES E FE nt 1 EFE
423. 357 2 13 2 H272 8 H272 P210 P370 P378 P501 P220 P221 Es Bye P280 pi S KEBY XZ EIGKE BC BGE 358
424. QSAR C 1og Kow 2 Hansch Leo Hansch Leo H N O N Ep es P Ea S log Kow wats ad 1979 l AE iB r2 0 967 7000 version 1 2 r2 0 89
425. oe 434 A6 1 7
426. 1 H340 lt gt 2 H341 lt gt lt gt Cth MOREO OBBBAE CRW ED AERJ MEA AP CWSBHA A ECE ERRI Oo P201 P308 P313 P405 P501 P202 P281 385 3 6 1 H350 lt gt 2 H351 lt gt lt gt CID MOKED 5 ORRERA ETRO E BREE MA APCWSBAE HECHE MET 5o P201 P308 P313 P405 P501 REELIRBORARHSGA
427. 3 1 3 H331 P261 P304 P340 P403 P233 P501 Kein DEIR EER IEA ES ONE ETF TEDHA P311 P271 P405 P321 KAOFNW GME BL EGG 374 3 1 4 H332 e
428. BH 5 2 1 3 2011 1 1 255 1 PEERY D R IZ BT BE ETILA AN LARBRAOE iki ae SRE a HI 6 8 A 256 REO 1 2 3 4 5 Gs Gs BEE RODZIC BIT SAE EF 6 2 FR A 6 257 1 2 3 4 5 Ae Ae
429. 1 2 3 4 5 P235 2 6 1 2 3 4 2 8 2 A B C D E F 2 11 1 2 2 15 A B C D E F P240 2 1 E aie BUR T D 1 1 1 2 1 3 1 4 1 5 SAA 2 6 1 2 3 TERRE EMA ZETHA Win EBRA GE LUBE IEA SHSIFE EEE CHSBGE 2 7 1 2 APE RUH RCHA ERA LAT GE _ P241 2 6 1 2 8 2 7 1 2 PCAEZRBEETS Z THEE DEBS P242 2 6 FE 1 2 3 P243 2 6 1 2 3 P244 2 4 1 P250 2 1
430. 2 28 gt VAS 2 FE Wy A9 7 1 8 E pH E
431. 2 15 C D E F H250 2 9 1 2 10 H251 2 11 1 H252 2 11 2 300 GHS 1 2 3 4 H260 2 12 1 H261 2 12 3 2 3 H270 2 4 1 H271 2 18 1 2 14 H272 2 18 2 3 2 14 H280 2 5 H281
432. I A4 8 6 1 An OFPMBE BDA BLAMES A4 3 6 1 1 H RAFSBEAICAHLT a SDS 8 b c 410 A4 8 6 1 2 KAFRA LT PVC A4 3 6 2 RELOP LAE
433. 3 2 1A 1B 1C P360 2 13 3 1 i ain 2 14 1 P361 2 6 H 1 2 3 3 1 1 2 3 3 2 1A 1B 1C P362 3 2 2 P363 3 1 1 2 3 AMEE 3 1 4 3 2 1A 1B 1C 3 4 1 1A 1B P370 2 1 1 1 1 2 1 3 1 4 1 5 2 4 1 2 6 H 1 2 3 4 2 7 1 2 2 8 A B C D E F 2 9 1 2 10 1 2 12 1 2 3 321
434. 4 DRE ORMOBASN LY BE AE Ch riziere 3 PEAY 1 x M x100 2 x 10 3 25 M 4 1 3 5 5 5 5 RERDO IS 1 FEL EIZ Ol CAIN THER ZV EEL MIIOGE AF CE SPRAY COAL K x 1 YARLOUHMRT Y Ob B ODRE a HRIECHU 7K OPYRAREE OD SiH CAED b BCF 500 log Kow 2 4 NOECs gt 1mgyL be Hy aise yy a ss WS 2 A a a BE OREORE PEE 3 DRE OFM OG ENR OREA UE CHIPS 4 1 2 3 4 2 25 4 RERAO 96 1 ERLE EIZO CAA TENGE Lal VE DIOGE AFT ARE AVY COL K x 295 A2 29
435. E E Me E E Fz FA 502 log Kow A9 6 3 4 A9 6 3 5 OO Ee
436. P373 ROARK Te DHAKAD LAOI E RYE SE LEAR TE RIEL EEL GA ELRE EHR E OREFERIEDBIST EAE A he P240 KHATER MOE Ci BGG P250 P280 337 2 1 B CEER 7 a a 1 4 H204 ZOE P210 P370 P380 P401 P501 AKERE DDOL IRAK POR
437. 21 eee c 1 Hae d in vitro DIRAI f e 3 2 1 1 j T2 EDER ETES E 2A 3 3 2 BRYOF 2BAFCERLUGE O72 2 ORAZ 3 3 3 2 DLE OSM OA SNA BE a Hpt H 2A i HOR SED KA 1 1 3 ii 272A 10
438. x 9 A2 28 a KERAMA FIE FEAL 4 1 AZDA EX 1 YARBLUART Y ODDS SEI OB ES 10 mg l lt L E Cso lt 100 mg l ages L E Cso 96 LCso 48 ECsyLCs 72 96 ErCso LERYIOF 2 BAF CAAV GE OREORE AM 4 1 3 4 3 a E a a 4 3 5 5 3 1 x M x 100 2 x 10 2 25 M 4 1 3 5 5 5 4 1 3 5 2 4 1 3 5 8 3 10 mg l lt L Cso lt 100 mg l a YE 4 1 3 5 2 4 1 3 5 5 3 3 1 x M x 100 2 x 10 3 gt 25 4 BRERDO IG 1 ERE EIO CHIN TREO
439. 1 3
440. 2 2 FA CHAK CHA SDS 1 DUKE 437 BES ROE ICHAEL TRO ETC DA E
441. 3 1 3 H312 3 1 4 H313 3 1 5 H314 3 2 1A 1B 1C H315 pare 3 2 2 H316 RZJ ERRATE 3 2 3 H317 3 4 1 1A 1B H318 BR7TRORG 1 3 3 H319 2A 3 3 H320 2B 3 3 H330 38 1 1 2 H331 3 1 3 H332 3 1 4 H333 3 1 5 H334 or 3 4 1 1A 1B H335 NN E HERR 3 3 8 H336 eee HERE 3 3 8 H340 MOBS ORE OA
442. 3 5 1A 1B ETO E BAENA AN TOBBE PEE Z RT B H341 MORDOR A 3 5 2 TAS CLAW EBREMIZMHM SAN TWS FAECES HRT 3S H350 ees eh Hh DIED OREBDBAZEC 3 6 1A 1B BW EBREHNCHEY SNT SGE FE LIEDER E AORT D 302 GHS 1 2 3 4 H351 MOO ORES 3 6 2 AETR E PAEPAE AH TOSH A AECE HET S H360 8 3 7 1A 1B DAWL TS COREE ZT BNMAEE ANTS HA DIEE D 5 ORDA EG CA E DEBI HASN TODHAR ECEE RMT S H361 3 7 Bt 2 UDOWILTR COREE ZIT OIMBEZE IFZ MOKED ORBEA ETRO E DAEB AE EP CW BER FERKBE et O H362 3 7 H370 b UDAAILI COMBE 1 BI
443. 303 GHS 1 2 3 4 H301 3 1 3 8 1 H331 H311 3 1 3 3 1 3 H331 H301 KRAIAA TE RICHER LK OMATS LEE 3 1 3 3 1 H311 3 1 H331 H302 3 1 4 3 1 H312 H302 3 1 4 8 1 3 H332 H312 3 1 4
444. 4 SDS GHS SDS 1 5 GHS 1 CA GHS SDS 4 1 2 4 1 3 1 SDS GHS GHS A4 2 SDS A4 2 1 BGA e ie SDS GHS SDS D9 y RATHER DRET
445. 85 ppm Be COLL DSL TRAIT pa N GHS 3 200 1000 mg kg 720 HE 24 3560 mg kg 2 MIETI 830 IS Lo RRAZ WHEE A8 4 2 A F BRITE 7 6 3 Llc 7
446. A9 1 8 J A9 1 9 A9 3 E E A9 4 ffi A9 5 FE
447. SPARC log K 5 KOWWIN CLOGP 1 530 fe gt SPARC log Kow 1og Kow 1 log Kow Howard Meylan 1997 CLOGP Hansch amp Leo 1979 CLOGP Daylight 1995 n 8942 r2 0 917 sd 0 482 n 501 r2 0 967 n 7221 r2 0 89 sd 0 58 LOGKOW KOWWIN Meylan amp Howard 1995 SRC 140 260 n 2430 r2 0 981 sd 0 219 me 0 161 n 8855 r2 0 95 sd 0 427 me 0 327 AUTOLOGP Devillers 1995 Rekker amp Manhold 1992 66
448. Kow 2 A9 5 5 FWEXF A A9 5 5 1 A9 5 5 2 BCF BCF log Kow BCF BCF BCF A9 5 5 3 Kow log Kw
449. 244 1 246 GHS SEY Et PAE 1 SERRA BETZ F ABEWERILK DAS EERO MAE IT SIDE EF MAL ORE SCV SBAIL CHS 1 1 1 2 1 3 Shia 1 5 BR 1 6 HERIOL MEREL 1 5 1 6 PEF a ymin BRE EHER REESE BEM ytor Ki mm RERE WESSEN ae BEEF EE RMOMEIZIT SME EF AKANCER 1 1 1 1 2 1 8 BR Hs 1 1 1 2 1 3 1 2 1 4 1 5 1 6
450. 3 OECD 1997 tp 2 3 A E 4 EE ARAE E 489 H H E gt 1H A9 4 2 4 14 A9 4 2 4 14 1 QSAR
451. 4 486 p 1 A9 4 2 3 BODs COD 5 ieee BODs ThOD A9 4 2 4 COMME b d5AF HHL lt S Gul oH FT BOD 4 BODs
452. CO pH K A10 1 2 EFFI AWE TSE BERET h 2LOPER BAER L ORIEL LINCS DEEZ ON RM FZ EHRANSE LPL T I ORGBLELAWIEDF EGANL FET LREGAROKHBYKE ILE OECD202 208 D2 XV AR VEADI REMERA B EBEBAR EBSD LNB BIKIBI S CaCl 2H20 KC MgSO 7H20 DIREZ ISO6341 OBIKO 5 BO WEF CRITFUL FRAN REWIENLE M ARRELIRINT AUF BIZ OZC 2 7 DA A EMRAN BOTHH CHS 552 A10 1 NaHCOs 6 5 mg l 12 6mg l 64 75mg l 194 25mg l KCl 0 58mg l 2 32mg 1 5 75mg 5 74mg CaCls 2HzO 29 4mg l 117 6mg l 294mg 29 4mg l MgSO4 7HzO 12 3mg 49 2mg1 123 25mg l 123 25mg l CORE 0 50 0 10 0 038 0 038 pH 6 09 7 07 7 98 8 5 Yt 1 pH 4 FACT Facility for the Analysis of Chemical Thermodynamics http www erct polymtl ca tactfact htm A THALE bO CHS te 2 ZO haU pH Hf 6 0 8 0 22 COR G HED GB AA COW SDS AKII pH5 5 H45 DEMS DOTIAU pH8 5 ORRI BB F CILAN ATH AF TU 220 A10 5 1 8
453. b 3 0 3 7 3 3 3 7 1 lt 4 A2 24 b 3 7 tees 1 BAP L URAT Z OD SHAD 3 7 2 SN eee E 2 LEYOR 2BAFCELV GE DOE 3 7 3 2 en ZL 3 RA EAE BS pn 1 ld arr 2 a 0 1 3 7 3 3 3 7 1 1 b 0 3 3 7 3 3 3 7 1 2 288 A2 25 ERR 3 8 1 YARBLUART IDDBA 3 8 20 oe
454. 3 1 1 2 3 4 5 3 2 1A 1B 1C 3 4 1 1A 1B Rar HERR KENYA 3 3 8 3 P305 AEE 8 2 1A 1B 1C 3 3 1 8 8 2A 2B P306 2 18 1 2 14 1 P307 RELEE 3 8 1 P308 RRECILREORAR SORE 3 5 1A 1B 2 E 3 6 1A 1B 2 3 7 1A 1B 2 Ohi 1 2 3 4 5 P309 3 8 2 P310 3 1 1 2 3 3 1 1 2
455. A6 5 10 2 5 HRS SET AA CHS 2 A6 5 10 8 _ 5 2 A6 5 11 A6 5 11 1
456. BCF 500 4 1 1 FA A9 5 2 3 9 A9 5 2 3 9 1 f if 1 f A9 5 2 3 9 2 A9 5 2 3 9 3 BC BCF BCF OR FA He JERAT 1 T ADY 1995
457. Hh 28 1982 LAN E EZK BCF LD 1 bie ane ences ton 28 K z log 1 69 0 531og Kow da ln 1 0 95 k2 ee E 2
458. LCso lt 100ppm EEE LCso lt 0 5 mg l GER LCs 0 05mg l pee zii 2 LD 5 gt 50 mg kg LDso 50 gt 200 mg kg OEE LCso 100 gt 500 ppm LCso 0 5 gt 2 0 lt mg l GER g rears LCso 0 05 gt 0 5 mg l HF AE MEE Ab 3 5 LDso 50 gt 300 mg kg Gps LDso 200 gt 1000 Smg kg ba LCso 500 gt 2500 lt ppm LCso 2 0 gt 10 0 Smg LCso 0 5 gt 1 0 Smg l fale a Bric Hehe LES AY WATS LAEE ZR DE TAF 4 LDs 300 gt 2000 lt me ke tke EN LDso 1000 gt 2000 mg kg ER LCso 2500 gt 20000 ppm LCso 10 0 gt 20 0 mg l iy LCso 1 0 gt 5 0 mg Ab F
459. b d _ 2 LAYOFF 2BAFCEALU GA O 1 a 1A 3 7 3 2 1B 8 DREORN BB ANAVGE JER BORN 1 eae 1 oo 1 b 0 3 3 7 3 3 3 7 1 2 1 BARLOMHRT 2OLDSEE 3 7 2 4 ERI iP 2 ERWIESHT SEELT 2BRLWG 8 7 3 2 2 3 DREORN ABA ANAVGE IEE 2 fing MO cae EDI EIO KEV 2 0 1 3 7 3 3 BLO 8 7 1 3
460. 3 9 3 1 b 10 3 9 3 4 BLUE 3 9 3 2 DAIL ORRAT 2 Ob SEE 3 9 2 Cte emg 3 9 2 EE tp BPDP BAF CELU GE t Hn te ee E oe NN ER OLX OPA SFLZLU 3 A a P oe DREDD OREBE ET ae 1 10 a 3584 O ce a 19 3 9 3 4 3 9 3 4 E Gi 10 3 9 3 4 3 9 3 5
461. Sh A9 3 5 7 FOG A9 3 5 7 1 1mg 1 481 A9 3 5 7 2 P
462. a b c 3 7 3 OPPTS 835 8180 3 7 4 OECD 1999a OECD 1999b 2 OECD
463. ae TZIA NAS f A US BPA AQUIRE lt Mensink 1995 Pedersen Pedersen A D Be E PHJ A9 3 6 2 4
464. z a SDS CN a CT eee i SDS SDS 9 AN SDS DORR SDS Toan PPE SDS
465. 1 4 10 5 2 e ea GHS BEERDA BT SIE CF ARA IZED B FIKK FEXLBLORFRILMAR DURA CHRIS CE EBCEZ Ss 451 6 2 2 A 1 4 10 5 2 d 1 4 10 5 2 a 1 4 10 5 2 BAR 1 4 10 5 2 c 1 4 10 5 2 e BAR 462 7 GHS a GHS 200 1 b c
466. DLO H A9 4 2 4 12 OP 2 522 ik pH4 pH9 D SS ae a cl ae ee ee tz 16 A9 4 2 4 13 FI H GE Chi CaS E
467. Gobas 1989 Sees 521 RE CHET D log 1 47 0 41 log Kow Spacie Hamelink 95 0 MORA es 4 E OECD 305 1996 ECETOC 1995 1 BOTF 7 gt k F ko EEr
468. 0 JE ORN VIKE 279 A2 18 AERE FURIE FRUIRE 3 2 FEB EX ee 1 BAR ORRAT I Ob BADHA BA 4 a 3 2L OREO CYA 1 5 2 8 K 3 2 2 2 RYO 2BAFCEALUV GE O72 X ORE 3 2 3 2 3 3 DLE OSM OA ETA GE a 3 Gi 2 1 10 Gi 3 10 Gi 10x 1 H 2 1 10
469. 0 4 ProLogP 631 632 9 IV 1 0 1 1 4FHAOKES S HD Tit E 1 3 WAL MecCarthy Jimenez Shrap Opperhuizen 1990 RE ZR AAR
470. 2 12 1 2 3 2 13 1 2 3 2 14 1 2 3 2 15 A B C D E F 3 1 1 2 3 4 3 1 1 2 3 4 3 1 1 2 3 2 1A 1B 1C 3 4 1 1A 1B 3 4 1 1A 1B 3 5 1A 1B 2 3 6 1A 1B 2 3 7 1A 1B 2 REM iste E MERE 3 8 H 1 2 331 1 2 3 4 5 P501 3 fi BE 3 8 3 3 8 3 9 1 2 3 10 1 2 4 1 1 2 3 4 1 1 2 3 4 P502 4 2
471. 302A C 60 COs 28 MITII OECD B E 73 PETE DDE 9 DAR SREDA E ThOD COD 50 ThOD 5 A O BDENMHERRO RU C 9 C 12 OF AR ASTME 1625 94 3 3 2
472. A38 3 2 1 A3 8 2 2 ra f E E E H H FUN fi I RA EP A3 3 2 3 GHS 1 4 6 3
473. A9 4 A9 4 1 A9 4 1 1 1 1 EE 00 BODgCOD gt CAS pail a FA
474. CO gt 1 WEES Ze ETF gt SB AA 11 20 28C 1 5C H 100mg 5 24 554 lL 209 E Ay 3 10 15ml TS A10 5 1 9 3 A10 5 1 10
475. A9 6 3 6 T QSAR A9 6 3 7 Mikike LTE g F73 H QSAR o 8 Veith 1989 PONY By REAR BPE
476. K SAN cae St raat eee GAN Ie tae tee i n HPLC Kov HOF FEEN ae REMUS M ee ee HPLC log K 0 OECD 117 1989 E 4
477. Oe hae BE IID K RAH V 494 9 VI f A9 5 2 2 U A E MM Ba
478. 12 A8 4 5 2 3 ES Ee E aL NOEL a A8 4 6 DANE OBEHNE E GI A8 4 7 ASBMB PYRE Ames vitro
479. 146 2 2 4 CC 208 3 2 5 2 6 PaCO 7 2 7 gcm3 0 887 0 890 28 1 5 04 2 9 mg kg C 2 10 mg kg C 0 99 ww 2 11 log Pow 2 12 C 81 7 90 6 v v 12 EBB 8 4 C 2 14 2 15 A8 4 A8 4 1 AHEHE A8 4 1 1 O GHS 4 300 2000 mg kg LDs EGHE 0 89 scm 458 A8 4 1 2 KA ge eels DRECHA L TRR SIU ERIC IEE EEH ZR RPEO URI TR E sears ppm 85 ppm 0 5 mg
480. H 2 9 1 JARKE 2 10 3 1 P223 2 12 1 2 P230 2 1 J 1 1 1 2 1 3 1 5 RE E Pe IET O E XZ LS BERGE EPRE PRIZE V IEFSEBAEDIET GE P P231 2 12 1 2 3 P232 2 12 1 2 3 P233 2 6 1 2 3 3 1 1 2 3 ER DEIR ERKE E MAJIRA ree AERE KOE 3 APSE ETEINE CH SEBAE 3 8 3 3 8 P234 2 8 A B C D E F 2 15 A B C D E F 2 16 1 31
481. HPLC 1989 Tolls Sijm 1993 OECD draft Guideline 1998 REHE 528 E QSAR tA E E De Bruijn OECD 2 2 2 FAX RRE 2 n 1og K 2 n 10 2 2 3 HPLC HPLC Wt GAO bef 6 2 2 4 MEFE 1og Kow 8 2
482. ym S P370 P378 KBY ADP EMKACEGE 353 2 11 5 wy 1 H251 2 H252 a P235 P410 P407 GUO PICHE HEJTI L P280 jm P413 kg C P
483. 3 A10 5 3 2 1 A10 5 3 1 1 A10 5 8 2 2 7 28 7 28 2 6 1 4 7 2 10 15ml A10 5 1 10 pH A10 5 1 10 J 28 7 E 1 2 2 2 A10 5 1 6 A10 5 1 8 10 15ml H
484. 3 BOT FR L B Osn NOEC 1 FI o TE BA v 4 W E E
485. 3 1 1 2 BARH 3 2 1A 1B 1C 3 3 1 3 10 1 2 P311 3 1 3 3 4 1 1A 1B REA iste VE BAAR Ge 3 8 1 2 P312 8 1 4 8 1 5 3 1 3 4 5 3 1 4 3 1 5 3 8 3 3 8 3 3 P313 3 2 2 3 3 3 2A 2B AREE 3 4 1 1A 1B 3 5 1A 1B 2 3 6 1A 1B 2 3 7 1A 1B 2 3 7 P314 3 9 1 2 318
486. 3 2 1A 1B 1C SPER a EME 3 10 3 1 2 P332 E 3 2 2 3 319 1 2 3 4 5 P333 3 4 1 1A 1B P334 MCW KITT I LAbo kA CBI H 2 9 1 4 2 10 1 2 12 1 2 P335 5 2 10 1 2 12 1 2 P336 2 5 P337 3 3 2A 2B P338 3 2 1A 1B 1C
487. 7Zzz BCF As BCF Crish Cwater D HEE L 1 2 4 BCF 1 2 5 log Ko 6 amp A H Ae HH 4 H 4 H log Kow log Kow 6 4 BCF FA AE LT Y
488. K y K Kow EE f tk eee FF 0 3 Ee Fa BE E II 1 BCF OECD 306 1996 A9 5 2 3 6 BCF a fe Kow BCF
489. 1 2 3 4 H400 4 1 1 H401 4 1 2 H402 4 1 3 H410 1 4 1 H411 2 4 1 H412 3 4 1 H413 4 4 1 H420 4 2 1 305 306 3 2 A3 2 1 FRX A3 2 1 1 EE cl ke Re RG es 4 1 4 10 5 2 vat He A3 2 1
490. EMA ErCso 2 4 1 3 4 3 LE ORD BST ENE GE a AES idea tale chee 4 1 3 5 5 2 1 x M x10 2 25 M 4 1 3 5 5 5 b 4 1 3 5 2 4 1 3 5 3 2 1 mg l lt LE Cso lt 10 mg l lt c 4 1 3 5 2 4 1 3 5 5 3 2 1 x M x10 2 25 4 PLERDO IG 1 EEL EI OL CAIN THER ZV EK MIOGE AFC SIRE AVY COAL K
491. ee E 749 525 4 4 1 4 2 7 S Scow 1982
492. 1 3 2 3 417 A4 3 11 14 BAHAR A4 3 11 14 1 A4 8 11 14 2 a a free b c
493. 3 VEE Mla a L H412 4 TEE lage L H413 P273 P501 LEEZNE LIE 398 4 2 1 Wk Ae H420 J P502 399 400 3 4 A3 4 1 1992 6 24 92 58 EEC SABS 0265 1999 401 402 4 SDS 404 A4 1 FRX 4 1 1
494. LUD HEMET CZ BPRPEDPEWIZE CHS BSH L RIF ASAE EE RIRICIE Zahn Wellen RK OECD TG 302 B amp MITI IT HW OECD TG 302 BHD fE JUAFVHLEL POEBY CHS a FRNCRBE LE ELE BEDEHV CELLS ZV CHECHRORABIZBI CT HUEFFVLIR ONE NE Ch RROARPEITAEBYL CHY BIBL SAVRBLOSIUC LET O FRIE ERLE FOL I CHS MITI 77 Afg L NIL gt 60 14 HELA Gi Zahn Wellen BR gt 70 7 HLA 488 A9 4 2 4 9 A9 4 2 4 1 JEW oT amp STP HCO ASME 2 A
495. Langenberg 1996 Q SAR QSAR A9 4 2 4 15 H
496. 1 332 3 3 A3 8 1 X A3 3 1 1 GHS GHS a A3 3 1 2 GHS 1 3 2 2 1 EN A CN 5 Bt A3 3 1 3 A8 8 1 4 TIPCS Z129 1 A5 1 1 Fe AN a BA AR A3 3 1 5 A3 3 1 6
497. 1 1 3 7 1 2 276 A2 15 2 15 as EE RE BIT SHG PRI k OPEN A FEO RMERLY Y A A H wR 7 TESERO IC BIT SOL PRT L OAE HA FU BORRY Y R A H 2 15 2 15 4 1 E LESERONBEIZ LTT SE AB ISL OME ALE FS BORER VU I ANH 2 15 2 15 4 1 OF TESERO IBIS BIG PRI L OHE HAA BIROR Y R A H 2 15 2 15 4 1
498. 4 IPAMO b D gt 6 SITS ZT EEWRTEZWE 2 13 1 2 3 E N 2 14 1 2 3 Bre P211 7 2 8 1 2 P220 2 4 E 1 re ree 1 2 8 BAT SNE T PELNE B A B C D E F Z 2 13 2 3 2 14 2 3 2 15 A B C D E F 2 13 1 LP TRIO Bi EIFS 2 14 1 SETET OTE 310 1 2 3 4 5 P221 2 18 1 2 3 2 14 1 2 3 P222
499. 9 1 30 508 BB niri o 50 L ee f o be 8 AED o rme a a EREARO RMD AR N IZMERE APIID E 5 PD DEERE ZA IBERA CO BME BEA BRETTI Z LEERT D A6 5 3
500. A6 5 12 AIk OREI FIE A6 5 12 1 A6 5 12 2 a 4 b GHS
501. Aa i 2 ER 5 1 1 2 8 EAB RO WIE es WIS 5G CFO AN E BEBROE ah gt 3 BEN a 5 1 254 A BAT B C D EEF G BREBHATEHNT WAV ees 0 2 EEE O tale GF BMG tT AJTE SIV TU 1 B HARADI RIT SMEG ETARA RARE 181 8 3 2
502. 2 14 1 324 1 2 3 4 5 P 3 8 1 P311 P308 3 5 1A 1B 2 e 3 6 1A 1B 2 3 7 1A 1B 2 EIEE PEFLICM ST SE KML 3 7 a 3 8 2 p311 e 1 3 2 23 P313 ae 3 4 2 1 1A 1B P313 Ri P335 2 10 1 P334
503. 2 5 H290 2 16 1 301 A3 1 2 GHS 1 2 3 4 H300 8 1 1 2 H301 3 1 3 H302 3 1 4 H303 3 1 5 H304 Se 3 10 1 H305 3 10 2 H310 3 1 1 2 H311
504. P102 P103 GHS A8 8 4 A8 8 4 1 A3 3 4 2 BEDANI ArI E CHE SAAD MSIL EREBXOWMAOLOOERCHD IN A3 3 4 3 A3 3 4 4 JERSE A8 8 4 5
505. SH 4 FE SHH AY A H E LE Cso a LEC 1 E ce 1 T b 0 2 T c LCso 3 L E Cs0 2 ON e a CT rere 3 A9 7 5 2 4 2 28 A9 7 5 2 4 1 1
506. ae i lt ad LDso a He LCso LDso 2000 gt lt RE ee TEREE mm EN IA O 4 1 a A RR c 4 sa BBE ae 278 A2 18 3 2 EZAR 1 YARUARET Y Ob BUCADA a cee b BE ue O 2 11 5 pH d in vitro 1
507. eM a b oS L E Cso OD UN CB Wes E
508. 1 A9 3 2 5 2 EPA 850 1500 OECD 210 Bp ba E 7 200 A9 3 2 6 PPE Part 1 US EPA OPPTS 850 1035 A9 3 2 6 2 3 fet E f HERBAR b E Z HEH Te AR A9 3 2 6 1 at 96
509. A10 5 1 6 pH IMAC ZAYED pH A10 5 2 3 A10 5 2 3 1 ae A 5 A10 5 2 3 2 ya IL Aas BEF 2 ORGY 3 2 37 44 um 10 l Ale A10 5 2 3 3 pH 3 E 1 30 pH
510. A3 1 8 1 1 2 WIE TREC ORD ELURRA MOBD5OBRBOAAE CHIE DREHTE ENTO BFE HECEBERET S 8 PIAULTI S COPBE LS OMMABEEAITS T 0 T 3 Hi GHS X 4 x gt m2999 A3 1 2 3 A3 1 2 T H300 H310
511. i j Ff 0 HDS oe a b c 28 16 A9 4 2 4 11 ETH 4 AYRE OECD 303 STP gt 0 043 day
512. 1 BARL URAT Y Ob BES 3 6 2 SA 2 LDF 2 BAF TE ROH FE as ry cal et ul oH 1 3 6 3 2 Oy E SAS a ye a BEIO E CUDDA A 2 a ee es 1 b 1 0 3 6 3 3 3 6 1 2 I OMEI Oo ARO FHL HE E T OPUINE E B 287 A2 24 a 3 7 ps 1 A BLORE Z Ob BWA 3 7 2 a
513. 20 Cis Pil Cs H HPLC p ANIH en FF Kov 2 AME F 225 ro log Kw ras AL os a ICHEAU CWS R log ae 4 5 Doucette Andren 1987 1988 Shiu 5 1988 Toxic Substances gt lt ae a IESCA H
514. 509 O 0 1 day 7 A9 4 3 3 2 28
515. A A9 3 5 9 AMRAKOLH A9 3 5 9 1 pH pH 1 MW ayMWi A9 3 5 9 2
516. A9 7 4 8 B BCF gt as DEE log Kow a ITE Ch al CF BCF Ay Cri en AL LIER IC PER N 1 E lt
517. E E E EE BONY BE BCF BCF E F T 1log
518. NR ae ME OD aie HHN 7G A9 3 3 2 2 o iba A E HEIZ E 5 F ba 8 A9 3 3 2 3 war ee K 0 1mg l EB k URHE et E 2 E Bil 1ppm mgA E 1 gt E 14 4 OECD E Lemna END AEH E
519. 1 201 232 Abt Associates Inc 1999 Consumer Labelling Initiative Phase II Report Cambridge Massachusetts Prepared for US EPA Viscusi W K 1991 Toward a proper role for hazard warnings in products lability cases Journal of Products Liability 13 189 1638 US Consumer Product safety Commission 2001 Code of Federal Regulations Subchapter C Federal Hazardous Substances Act Regulations 16 Part 1500 Saouter E G Van Hoof C Pittinger and T Feijtel 2000 A retrospective analysis of the environmental protile of laundry detergents submitted to International Journal of life cycle analysis October 2000 IPCS 2001 Principles for evaluating health risks to reproduction associated with exposure to chemicals Environmental Health Criteria No 225 IPCS 2000 Human exposure assessment Environmental Health Criteria No 214 IPCS 1999 Principles for assessment of risks to human health from exposure to chemicals Environmental Health Criteria No 210 428 6 430 6 A6 1 RN SDS
520. 1B 2 WOBK 5 MDE DD fH DIER D D D BEBAECRL REBASCHR RBDH ETA CE BR EMI HE EBREKIZHE AZAUT OSHA HANTHSEFER FANT SFR REBRRBEEBE HELRBEBBS HERRE E iB FOR FERE AE RODRMEIZIT SME CT ABIALCISBLIE ENTR 1A 1B 2 fh DIE 025 D RBBH ETEV cE BEHI aE HARWSHE P E RRR E FERE fl DIER D D RRDA ACRU EBREHUC HE HASRCWSHER P E CREE E FERE 2 ff DIER 225 D RBDH ECRU EBREHUC HE HAR WSHER A ENRERE E FER EPER OWDEIEZ BIT BE ETNA TIIA SNAUT 261 1A 1B 2 RRL TEE Mae L 4 LAMNMLHEO 5 LAED 4LANTHBO ABR HRT 3 ABS HRT D ABS LETS E Et ORDD EIT GHD D MoR DREBEECL ORBBAE CLV OREBHECHU EDEP Z EBRI
521. 7 NO oa 250 A B RAF CED EEF G ZC ORGINAL FON BAO EIL y Dibpre iz ASL A M pee ne BIT SM er ET ABE mee AU CIES IVC 1 B BEER BORAT SMG ET NRANCEED lt RUBLE 181 2 3 3 R 7 4 g 1 B 251 1 ETE RDO tk l 8 TOME ETNA Fa A F ee HEM
522. BCF 1 Re 199 H AS E Connel 1990 BCF HTE log BCF log Kow Van Dem Berg 5 1995 Spacie Hamelink 1982 Gobas 5 1989 Petersen Kristensen 1998 E lt 4E ogy or Ale EA J a8 me a
523. BO SHAT amp ME CBU SHER O BE LDL RRE EN a pH G O Gi 3 By A Da A9 7 2 1 2 2 amp A9 7 2 1 2 3 HA E ME CRA 0 ee E 2 De A9 7 2 9 BRET 2 COMER A9 7 2 2 1 A9 7 2 2 2 3
524. Gi 10x 1 2 10 b 2B ena atte 2 3 3 3 3 4 283 A2 20 3 4 T 1 BEAR URET 2 Oh BADRA a y b y 3 4 3 2 BAR 8 a e GE BAROD iR n Shas Fe OO A ea Mi
525. METS CRE LRV R CL 3 2 1A 1B 1C P353 po 3 1 5 P312 P304 3 1 1 2 3 4 Pa40 8 2 1A 1B 1C 3 3 8 3 3 8 P304 3 4 1 1A 1B p341 P305 3 2 1A 1B 1C a 3 3 1 ee 3 3 2A 2B P306 2 13 1 pago
526. RERED Dab A9 3 6 7 OROMRMR A9 3 6 1 L BL OURBE MR H A9 8 6 2 F Z OFS A9 3 6 2 1 OECD
527. th log Kow pH Pedersen 1995 0 9 log Kow TemaNord 1995 581 CLOGP LOGKOW 2 gt es 2 3 4 AUTOLOGP Devillers 1995 800 FF AUTOLOGP C H N Ov P S log Kov log Kow log Kw
528. 3 DEFORMA SIRI BE BAMPDD 1B 2 Ta 1 0 285 A2 22 3 5 1A 1B 2 DABE URET Z OD BBA 3 5 2 a b PDF ZEBA FTE R EE 3 5 3 2 B H OREORE SNE GE 1 0 1 1 oY tt cok at oul OR ak e xa YEP at Itt E D ORRDA ETNO b NAE WHBLORRT 2 Ob BA 3 5 2
529. 5 2 b 1 4 10 5 2 c 1 4 10 5 2 e LEP AEE AETERNA EJL OA BLE EER OWE YT SRE EPMA ZED BIKAWIKOMRAL MERR SHORTS GHS KERRIER CHATS LERTE S 447 2 1 2 GHS 1 4 10 5 2 d 1 4 10 5 2 a 1 4 10 5 2 b 1 4 10 5 2 c 1 4 10 5 2 e BFR IERIE LEME ORRUA LEERY OW ELE DIT SS EFA IEDZ ILAVIEIKOMAERIL WIEBE GHS ATA CHATS amp BCE SB 448 3 2 2 A GHS
530. 7 ECOSAR US EPA 2000b EPA 1 US EPA 2000a QSAR QSAR H
531. 8 ri A9 5 3 2 E E E A9 5 3 2 2 4 I A BCF 498 3 E log Kow
532. Ct a 1 e c n 1 be ne gt n b mg l N Q t mg l a mg l b ce d n cd S 7 8 3 A10 6 2 2 Img 28 A10 6 1 A10 6 2 rs EG AR
533. LDPAPULI R COPEE ZS S WMA EBS S lt lt gt gt CIE MOIR ORBO HETUS E DREINE AN TOSHAR HECEBLMERT S P260 P309 P311 P405 P501 BD CANEIA AIS ARRAS U eERMALZE RELER EMO RAI P264 P270 390 3 8 3 H335 H336 P261 P304 P340 P403 P233 P501
534. OM BEA 3 4 3 2 B TA M es 3 sy eet a TB EARN ITO es 3 aerate LEEW EE L 4 a 1 0 b 0 2 284 A2 21 KAREE 3 4 ig 1 DER ORHAF Z DH 5 BADHA a e Ba a ther BRYOF 2 BAF CERUGE 1 3 4 3 2 3 OCE ODARA SNE EBS RAPo
535. ZV BR DRE AFT ARE AVY COL K x 293 A2 28 b 4 1 1 REET SYAOGE a NOEC lt 0 01 mg l b L E Cso lt 1 mg l BCF 500 log Kow 4 aia 2 EPHEL PEDRA a NOEC lt 0 1 mgl b L E Cs0 lt 1 mg l 3 BRYOF 2 BAF T R GE ORE DRAN 4 1 3 4 4 OR ORRIA SNAG NP CHAUTIBPE 1 1 x M Z 25 HERS M 4 1 3 5 5 5 5 BLERAO J b 1 FERAL LIZ OU CAA AT RE ZI OS Lev CDRA KF CE SIAR AVY CORAL K x 1 REMET OPADIE a 0 01 lt NOEC
536. chemicals OECD Paris 1993 http www oecd org env testguidelines d OPPTS guidelines US EPA http www epa gov opptsfrs home guidelin htm e ASTM ASTM http www astm org standards 2 OECD Test Guideline 201 1984 Alga Growth Inhibition Test OECD Test Guideline 202 1984 Daphnia sp Acute Immobihsation Test and Reproduction Test OECD Test Guideline 203 1992 Fish Acute Toxicity Test OECD Test Guideline 204 1984 Fish Prolonged Toxicity Test 14 Day Study OECD Test Guideline 210 1992 Fish Early Life Stage Toxicity Test OECD Test Guideline 211 1998 Daphnia magna Reproduction Test OECD Test Guideline 212 1998 Fish Short term Toxicity Test on Embryo and Sac Fry Stages OECD Test Guideline 215 2000 Fish Juvenile Growth Test OECD Test Guideline 221 Lemna sp Growth inhibition test EC C 1 Acute Toxicity for Fish 1992 EC C 2 Acute Toxicity for Daphnia 1992 EC C 3 Algal Inhibition Test 1992 EC C 14 Fish Juvenile Growth Test 2001 EC C 15 Fish Short term Toxicity Test on Embryo and Sac Fry Stages 2001 EC C 20 Daphnia Magna Reproduction Test 2001 OPPTS Testing Guidelines for Environmental Effects 850 Series P
537. for environmental effects testing Chemical fate test guidelines and support documents United States Environmental Protection Agency Office of Pesticides and Toxic Substances Washington D C 20960 EPA 560 6 82 002 1982 8 Code of Federal Regulations Protection of the Environment Part 790 1993 7 1 ONLINE US National Technical Information System EPA FIFRA 1982 The Federal Insecticide Fungicide and Rodenticide Act Pesticide Assessment Guidelines subdivision N chemistry Environmental fate and subdivision E J amp L Hazard Evaluation Office of Pesticide Programs US Environmental Protection Agency Washington D C 1982 ONLINE US National Technical Information System OECD Test Guideline 107 1995 OECD Guidelines for Testing of Chemicals Partition Coefficient n octanol water Shake Flask Method OECD Test Guideline 117 1989 OECD Guidelines for Testing of Chemicals Partition Coefficient n octanol water High Performance Liquid Chromatography HPLC Method OECD Test Guideline 305 1996 Bioconcentration Flow through Fish Test OECD Guidelines for Testing of Chemicals OECD Test Guideline 305 A E 1981
538. incorporating discrete site electrostatic model of ion binding by humic substances Computers and Geoscience 20 6 073 1023 645 546 10 548 A10 1 FRX A10 1 1 10 Ly ay Si 1H
539. le BUT A ERRI SHAD EFE NAA DRAR RAHI kUI E CAK 28 E 1 211 10 0 1 5g 96 96 OECD U te aa WEE 24 OECD 20
540. lt 1 mg l b 1 mgl lt L R Cso lt 10 mg l BCF 2 500 14 log Kow 2 4 2 REPEL PADRE a 0 1 lt NOEC lt 1 mgl b 1 mgl lt L E Cso lt 10 mg l 5 3 BEYOF 2 BAF T R GE OFF EF DRAN 4 1 3 4 4 DREORMD GT SPU BA 2 1 x M x 10 2 25 M 4 1 3 5 5 5 i 5 ALERAO J 1AL EI OL CA TREN IR ECAD KF CE SIBREAVYCOHAL K x 3 T OREIKES 294 A2 28 b 2XKERGBIER BIE GEWLE 4 1 EBL BEX YERE ARET SYAOGE S 0 1 lt NOEC lt 1 mg l b 10 mg l lt L E Cs0 lt 100 mg l BCF 500 1 og Kow 4 2 LEME LL PADE 10 mg l lt L E Cs0 lt 100 mg l BERYQOR 2 RAFTE Z GE ORE DRHZ W 4 1 3 4 oe
541. m CAU TWA RH A9 6 1 2 Corwin Hansch Overton 1901 C 4 5 1 Konemann 1981 4 K nemann Dy E 1 H log Ko B 137 QSAR Kay COLT ASF ef SAUTE QSAR gt log Ko 4 COMAINLEYEMO THEVtD b S log Ko 4 COMQIMLADRMO THEIL Overton Lipnick oye Studien ber d
542. ome Biodegradation Probability Program YT QSAR QSAR US EPA EC QSAR ae UL D22 Q SAR 9 II 1 FF 1 1 OECD
543. sludge micro organisms by chemicals and wastewaters 2 LLFOY X kit2000 9 AHFRDO BOCA BLO FILS ORM BSVVLCORRFOMGS CC ER HZ EET ESLER b B 536 ISO 9887 1992 Water quality Evaluation of the aerobic biodegradability of organic compounds in an aqueous medium Semicontinuous activated sludge method SCAS ISO 9888 1991 Water quality Evaluation of the aerobic biodegradability of organic compounds in an aqueous medium Static test Zahn Wellens method ISO 10707 1994 Water quality Evaluation in an aqueous medium of the ultimate biodegradability of organic compounds Method by analysis of biochemical oxygen demand closed bottle test ISO 11348 1997 Water quality Determination of the inhibitory effect of water samples on the light emission of Vibrio fischeri Luminescent bacteria test ISO 11733 1994 Water quality Evaluation of the elimination and biodegradability of organic compounds in an aqueous medium Activated sludge simulation test ISO 11734 1995 Water quality Evaluation of the ultimate anaerobic biodegradability of organic compounds in digested sludge Method by measurement of the biogas production ISO DIS 14592 1999 Water quality Evaluation of the aerobic biodegradability of organic compounds at low concentrations in water Part 1 Shake flask batch test with surface water or surface water sediment suspensions 22 11 1999 OECD Test Guideline
544. 1 65 11 1 1 2 rer ee A2 14 2 14 DO a or SPRINTS BI ane ER 8 2 4 1 E 1 1 IA 1 4 Ln 4 1
545. 1 1 H202 2 1 1 2 H203 KI 2 1 1 8 H204 2 1 1 4 H205 2 1 H 1 5 H220 2 2 1 H221 2 2 2 H222 2 3 1 H223 2 3 2 H224 2 6 1 H225 2 6 2 H226 2 6 3 H227 2 6 F 4 H228 2 7 1 2 H240 2 8 HATA 2 15 H241 H 2 8 B 2 15 H242 2 8 BAT
546. 111 1981 Hydrolysis as a function of pH OECD guidelines for testing of chemicals OECD Test Guideline 209 1984 Activated sludge respiration inhibition test OECD guidelines for testing of chemicals OECD Test Guideline 301 1992 Ready biodegradability OECD guidelines for testing of chemicals OECD Test Guideline 302A 1981 Inherent biodegradability Modified SCAS OECD guidelines for testing of chemicals OECD Test Guideline 302B 1992 Zahn Wellens EMPA test OECD guidelines for testing of chemicals OECD Test Guideline 302C 1981 Inherent Biodegradability Modified MITI test II OECD guidelines for testing of chemicals OECD Test Guideline 303A 1981 Simulation test aerobic sewage treatment Coupled units test OECD guidelines for testing of chemicals 1999 OECD Test Guideline 304A 1981 Inherent biodegradability in soil OECD guidelines for testing of chemicals OECD Test Guideline 306 1992 Biodegradability in seawater OECD guidelines for testing of chemicals OECD 1998 Aerobic and anaerobic transformation in aquatic sediment systems 1999 12 OECD 1999 Aerobic and anaerobic transformation in soil 1999 10 OECD 2000 Simulation test Aerobic Transformation in Surface Water 2000 5
547. 15 EAE LEE BROWNE AIG Me PRIL OHER 16 EWER Sea REACHED TRA FHERR L 269 A2 2 2 2 ds 101 3 kPa 20 1 a 18 b FADS 12 AAEN BRL I LER es ae E A2 8 2 3
548. 2 BRT OECD A9 3 2 7 ZAIM EH 7 AR A9 8 2 7 1 OBS AV RR PRO 2 RS RIGS HA CBSE LCRA BIC RET A OECD 201 MERIH 3 4 DMN CO PH 476 KR A9 3 2 7 2
549. 2 GHS 5 GHS 3 A3 2 1 3 A3 2 2 A3 2 2 1 a IP precautionary Statement b 1 2 13 4 5 c A3 2 2 2
550. 22 2 H223 P210 P410 P412 BATE PLAID DO DL I RRA 50 C ds P211 P251 342 2 4 B 1 H270 P220 P370 P376 P403 P244 Ze 343
551. 3 1 H332 H302 KAANE V RICHER LE OMATSZLRS 3 1 4 8 1 H312 8 1 H332 H303 3 1 5 3 1 H313 H303 8 1 5 8 1 H333 H312 3 1 5 8 1 H333 H303 KRAIAA TE RICHER LE OMATSZ LSS 3 1 5 8 1 H313 8 1 H333 H315 3 2 2 2B H320 3 3 304 K A3 1 3 GHS
552. 420 354 2 12 B 1 H260 2 H261 P223 P335 P334 P402 P404 P501 BBUTWIRWAFE RD OHO Ae P231 P232 P370 P378 P280 K Y RP EKA RPAEE
553. 6 ARGRORVBZU A10 6 1 R Y IRUR 24 A10 6 2 AMAR KLE OLEHET 5 A10 6 2 1 AGAR 8 7 a Ct Co kt mg l Co H t 0 mg C t mg l k mgl b KEF Ct A 1 e mg l Py mgl C t mg l k 1 c Ct A 1 e B 1 e mg l 556 x Ct a 1 b 1 C d t mgl AB mg l
554. AR Pederson 1995 E log Kow JED OECD OECD 1995 E TD bree eect SAR SLAVE J a je E QSAR A9 6 4 8 ECETOC QSAR QSAR
555. BERT SOL A4 3 4 1 2 a RL b 4 c d E Hm 409 JIREH PPE DH E E EESNOBE Ete A NOG A4 3 4 2 Bt BEREIH L AEDE TEKS WBE OC ARBRIC HDR TO Be b BBE REDS LOSER BIC OV COMME THIET SOE A4 3 4 3 LIM CE POLI E LEE EH S FEW LIEREOTER A4 8 5 5
556. Bioaccumulation OECD Guidelines for Testing of Chemicals OECD draft Test Guideline 1998 Partition Coefficient n Octanol Water Pow Slow stirring method for highly hydrophobic chemicals Draft proposal for an OECD Guidelines for Testing of Chemicals 3 2000 E9 AHEIOB OCHY LUD FILL ORAM bSIVLEOREOMMISEC TC EB PNW EHT ELLER DB 538 9 VI 1 APHA 1992 Standard Methods for the Examination of Water and Wastewater 18th edition American Public Health Association Washington DC ASTM 1999 Annual Book of ASTM standards Vol 11 04 American Society for Testing and Materials Philadelphia PA DoE 1996 Guidance on the Aquatic Toxicity Testing of Difficult Substances United Kingdom Department of the Environment London ECETOC 1996 Aquatic Toxicity Testing of Sparingly Soluble Volatile and Unstable Substances ECETOC Monograph No 26 ECETOC Brussels Lewis M A 1995 Algae and vascular plant tests In Rand G M ed 1995 Fundamentals of Aquatic Toxicology Second Edition Taylor amp Francis Washington DC pp 135 169 Mensink B J W G M Montforts L Wijkhuizen Maslankiewicz H Tibosch and J B H J Linders 1995 Manual for Summarising and Evaluating the Environmental Aspects of Pesticides Report No 679101022 RIVM Bilthoven The Netherlands
557. C D E F 3 1 1 2 3 H PEBRA FRKE 3 WS IE CTEFESE CH EGE 3 8 3 3 8 P404 2 12 1 2 3 hs 1 2 3 4 5 P405 8 1 1 2 3 3 1 1 2 3 3 1 1 2 3 3 2 1A 1B 1C 3 5 BE 1A 1B 2 3 6 1A 1B 2 3 7 1A 1B 2 RERA tE HeRR 3 8 H 1 2 3 3 8 3 8 3 3 10 1 2 P406
558. CHARMETET SOL A4 3 11 11 HEZEA A4 3 11 12 REOL FHS Z RR RE SDS A4 3 11 13 A A4 3 3 2 1 GHS
559. D EIRA 7 FE CO 72 VHS PAL 96 FFR ECs0 fh OECD 201 F RALAFO BD ICLVUREANS CILLEDHILIS COKELMHONRKR CHSEERARANSR D Lemna 4 COMOPIZIT SFT 2 b BRTEBAZYLbEOCHIAUL BEANS Eb HS 1 IEMET IIt BUEF BICLESNTAF LIES RRFIAO GA b ENEE ANTI Zev OECD 210 AHOWMBLISEUEEIEAR 202 Part 2 t 211 gt VY ADAR BEC 201 RERE hbo CHORAL F AILZITAN SHS MID TES PEASE AN JERU ZIAN ON T SAE bE CHL I NOEC KIZAEO LOCx ZAHO ZNE CHS OECD OECD 2006 A9 3 2 3 OECD
560. EKNTAE DE BRENT SHNWEGE BE SHTWSBGH HE ANT SER FE REEIEIB Ei LREEIEDE RORE REIEIB ES i TESTER ORE BIT BE ETNIE SATIR 262 HAE AR Be 1 2 3 gt b L NIR b LANES CRISES COM He LRT O HERTS Ch DIELDPSO MORERA D BEBE CR REBFECHU CE BREMICHE EDBREHKIZEE HARWSEHE HANTWSBE RELREEBE AEREE FERE FERR TESTER D RABITI BME ET ABAL TIRE SATIR 2 RMIT DEAZERNMRER i gt 8 LHPITBBEDPITS 5 LHNISHBE ZIT BCDB BT B BE COBPBE HRT O MORRO O ORBEA MORRO ORBO ETRU Z E DAE aE BERWSEHE HER RIEL ROR BECRHWS EBREK BH ARWSHE A SLREG SC RERE ELESE ROOD fmx BIT SME ETNA IRE SUTURE 263 Pay TESTER ORE BIT BE ETNIE SATIR 264 3
561. HsBO3 30mg KBr 100mg l KCl 700mg CaCls 2 H20 1 47g l NasSO4 4 0g l MgCls 6 H20 10 78g l NaCl 23 5 1 NasSi0s 9 H20 20mg 1 NaHCOs 200mg 1 34 0 5gykg pH 8 0 0 2 ASTM E 729 96 A10 5 1 6 pH pH 7 6 8 5 pH 28 5 5 8 5 ECO pH A10 2 3 2 A10 5 1 7 pH8 1 COs pH 0 2pH 10 7 pH7 6 pH8 8 5 pH
562. K Takatsuki M Peijnenburg W Rorije E and Struijs J 1999 Prediction of biodegradability from chemical structure modeling of ready biodegradation test data Environ Toxicol Chem 18 1763 1768 Meylan W M and P H Howard 1995 J Pharm Sci 84 83 92 OECD 1993 Structure Activity Relationships for Biodegradation OECD Environment Monograph No 68 OECD Paris France OECD 1995 Environment Monographs No 92 Guidance Document for Aquatic Effects Assessment OECD Paris F Pedersen H Tyle J R Niemel B Guttmann L Lander and A Wedebrand 1995 Environmental Hazard Classification Data Collection and Interpretation Guide for Substances to be Evaluated for Classification as Dangerous for the Environment 24 Edition TemaNord 1995 581 Nordic Council of Ministers Copenhagen January US EPA 1999 Development of Chemical Categories in the HPV Challenge Program http www epa gov HPV pubs general categuid htm US EPA 2000a The Use of Structure Activity Relationships SAR in the High Production Volume Chemicals Challenge Program http www epa gov hpv pubs general sarfinll htm US EPA 2000b ECOSAR http www epa gov oppt newchems tools 21lecosar htm US EPA EC 1993 US EPA Joint Project on the Evaluation of Quantitative Structure Activity Relationships Commission of European Communities Final Report July G D Veith R L Lipnick and C L Russom 1989 The toxicity of acetylenic alcoho
563. Kow 6 BCF 2 log Kow 2 1 R E RHE 2 1 1 n og Kow log K log Kov K log Kw Niimi 1991 1 Henderson Tocher 1987 Kov WA log Kow 2 1 2
564. LE Cso 100mg 1 L E Cso 100mg l 10 ae an SHE CHA mg l BORTE A9 7 5 2 4 A9 7 5 2 4 1 7 7 ea oll
565. M R WHAM Tipping 1994 MWe Rte SAO ROARS LOE Allison 1987 24 NN 51 10 WSIS SRAM DEE TSS
566. Neff 1981 Bioaccumulation and metabolism of phthalate esters by oysters brown shrimp and sheepshead minnows Ecotox Environ Safety 5 202 210 1981 4 QSAR Boethling R S Howard P H Meylan W M Stiteler W M Beauman J A and Tirado N 1994 Group contribution method for predicting probability and rate of aerobic biodegradation Envir Sci Technol 28 459 465 De Bruijn J Busser F Seinen W and Hermens J 1989 Determination of octanol water partition coefficients for hydrophobic organic chemicals with the slow stirring method Environ Toxicol Chem 8 499 512 ECETOC 1998 QSARs in the Assessment of the Environmental Fate and Effects of Chemicals Technical report No 74 Hansch C and A Leo 1995 Exploring QSAR American Chemical Society Hilal S H L A Carreira and S W Karickhoff 1994 Quantitative Treatments of Solute solvent Interactions Theoretical and Computational Chemistry Vol 1 291 353 Elsevier Science Howard P H Boethling R S Stiteler W M Meylan W M Hueber A E Beaumen J A and Larosche M E 1992 Predictive model for aerobic biodegradation developed from a file of evaluated biodegradation data Envir Toxicol Chem 11 593 603 Howard P And Meylan W M 1992 Biodegradation Probability Program Version 3 Syracuse Research Corp NY Langenberg J H Peijnenburg W J G M and Rorije E 1996 On the usefulness and reliabil
567. OECD 1998 Harmonized Integrated Hazard Classification System for Human Health and Environmental Effects of Chemical Substances OECD Paris Document ENV JM MONO 2001 6 OECD 1999 Guidelines for Testing of Chemicals Organisation for Economic Co operation and Development Paris OECD 2000 Revised Draft Guidance Document on Aquatic Toxicity Testing of Difficult Substances and Mixtures OECD Paris OECD 2006 Current approaches in the statistical analysis of ecotoxicity data A guidance to application OECD Environmental Health and Safety Publications Series Testing and Assessment N 54 Pedersen F H Tyle J R Niemeldi B Guttmann L Lander and A Wedebrand 1995 Environmental Hazard Classification data collection and interpretation guide TemaNord 1995 581 US EPA 1996 Ecological Effects Test Guidelines OPPTS 850 1000 Special Considerations for Conducting Aquatic Laboratory Studies Public Draft EPA 712 C 96 113 United States Environmental Protection Agency http www epa gov opptsfrs home testmeth htm OECD Monograph 11 Detailed Review Paper on Aquatic Toxicity Testing for Industrial Chemicals and Pesticides Rand Gary M Fundamentals of Aquatic toxicology Effects Environmental Fate and Risk Assessment 2 Boesten J J T I amp AM A van der Linden 1991 Modeling the influence of sorption and transformation on pesticide leaching and persistence J Env
568. PARC SPARC WO log Kow GQSAR US EPA EC CLOGP US EPA EC 1993 Pedersen 5 1995 CLOGP
569. PSA ROMF BEET SD LABRBE P261 3 1 3 4 3 4 1 1A 1B 3 4 1 1A 1B 3 3 8 3 3 8 P262 3 1 1 2 P263 8 7 P264 3 1 1 2 3 4 Sn a Tr TEEPE E ae T gt 3 2 1A 1B 1C 3 2 2 3 3 2A 2B ACK Se PE ILHE LHS SL 3 7 313
570. R ORBBAE CLAWS EBREHUZAA AN CWSGE HECE LMT S P260 P307 P311 P405 P501 P321 FR P264 KA D FEIRER BERGA P270 389 3 8 B 2 gee H371 lt lt gt gt lt gt lt gt ICI amp
571. RETE MORD ORBEA E CROT EBEP AEA AN CWSBEE H EIEE E RT Z H371 B LPPAMLT ROR 2 PEL LAT OMERIT MORD 5 OBE BBA CRW EDEP AEA AH TWS GE AERE E RRT B H372 RMICDKA EURER R SREO RE aE RRR 3 9 1 b LbARNILI COPBEZ IS OMAEE AIP SB MORBO ORBA ETRO L BRERA SN TOSHA HECE ZARIT B H373 REC OEZ EIKER ARERO REM Mb Tee REAR 2 b LODGNIIR COMEBLEZIT SIERE RKIFS MORD OBB BA ES CROT E BRAEPNU EREN CWSBEE FA E CIEE E LMT Z H300 3 1 1 2 3 1 H310 H300 3 1 1 2 3 1 H330 H310 3 1 1 2 3 1 FF H330 H300 3 1 1 2 8 1 H310 3 1 BE H330 H301 RAUNT RICHER 6 LA 3 1 3 3 1 H311
572. RIC Ra Lc eRRIC KS DB ERAO EH PEDRERA V AIEEE ZILDA ETA A4 3 11 9 MABLOURGREBIEL SEES RORE O OHNE SDS A4 8 11 10 DXMI GIEBIEDOHEE ZL GEtRIETHINObSSAE REBLORBAEICOW
573. S 6 H Am LAE Tae EL a b A EE c gt AES d
574. S 355 2 12 B K wy 3 H261 1 P231 P232 P370 P378 P402 P404 P501 P280 K Y RP ERK ACAES 356 2 13 B 1 H271
575. XXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXX XXXX XX XXXX XXXX XXXXXX 2 4 454 3 CHS UPC 8
576. assessments QSAR in environmental science VII Eds Chen F and Schuurmann G pp 185 205 Kimerle R A Swisher R D Schroeder Comotto R M 1975 Surfactant structure and aquatic toxicity Symposium on Structure Activity correlations in Studies on Toxicity and Bioconcentration with Aquatic Organisms Burlington Ontario Canada pp 22 35 Klopman G Li J Y Wang S Dimayuga M 1994 Computer automated log P calculations based on an extended group contribution approach J Chem Inf Comput Sci 34 752 781 Knezovich J P Lawton M P Inoue L S 1989 Bioaccumulation and tissue distribution of a quaternary ammonium surfactant in three aquatic species Bull Environ Contam Toxicol 42 87 93 Knezovich J P Inoue L S 1993 The influence of sediment and colloidal material on the bioavailability of a quaternary ammonium surfactant Ecotoxicol Environ Safety 26 253 264 Kristensen P 1991 Bioconcentration in fish Comparison of BCFs derived from OECD and ASTM testing methods influence of particulate matter to the bioavailability of chemicals Danish Water Quality Institute Mackay D 1982 Correlation of bioconcentration factors Environ Sci Technol 16 274 278 McCarthy J F Jimenez B D 1985 Reduction in bioavailability to bluegills of polycyclic aromatic hydrocarbons bound to dissolved humic material Environ Toxicol Chem 4 511 521 McKim J M Goeden H M 1982 A direct measure of the uptake efficiency of a x
577. e CSCL Japan Japan chemical industry Ecology toxicology amp information center ISBN 4 89074 101 1 Niemela J 2000 Personal communication to OECD Environment Directorate 20 March 2000 Nyholm N U T Berg amp F Ingerslev 1996 Activated sludge biodegradability simulation test Danish EPA Environmental Report No 337 Nyholm N amp F Ingerslev 1997 Kinetic biodegradation tests with low test substance concentrations Shake flask test with surface water and short term rate measurement in activated sludge In Hales S G ed Biodegradation Kinetics Generation and use of data for regulatory decision making From the SETAC Europe Workshop Port Sunlight September 1996 pp 101 115 SETAC Europe Brussels Nyholm N amp L Torang 1999 Report of 1998 1999 Ring test Shalke flask batch test with surface water or surface water sediment suspensions ISO CD 14592 1 Water Quality Evaluation of the aerobic biodegradability of organic compounds at low concentrations ISO TC 147 SC5 WG4 Biodegradability OECD 1993 Structure Activity Relationships for Biodegradation OECD Environment Monographs No 68 Paris 1998 OECD 1994 US EPA EC Joint Project on the Evaluation of Quantitative Structure Activity Relationships OECD Environment Monograph No 88 Paris OECD 1995 Detailed Review Paper on Biodegradability Testing OECD Environmental Monograph No 98 Paris OECD 1997 Guidance document on direct phototransfor
578. enobiotic chemical across the gill of brook trout Sa velinus fontinalis under normoxic and hypoxic conditions Comp Biochem Physiol 72C 65 74 Meylan W M and Howard P H 1995 Atom Fragment Contribution Methods for Estimating Octanol Water Partition Coefficients J Pharm Sci 84 83 Niemela J R 1993 QTOXIN program ver 2 0 Danish Environmental Protection Agency Niemi G J Basak S C Veith G D Grunwald G Environ Toxicol Chem 11 893 900 Niimi A J 1991 Solubility of organic chemicals in octanol triolin and cod liver oil and relationships between solubility and partition coefficients Wat Res 25 1515 1521 OECD 1993 Application of structure activity relationships to the estimation of properties important in exposure assessment OECD Environment Directorate Environment Monograph No 67 OECD 1998 Harmonized integrated hazard classification system for human health and environmental effects of chemical substances As endorsed by the 28 joint meeting of the chemicals committee and the working party on chemicals in November 1998 OECD 2000 Guidance Document on Aquatic Toxicity Testing of Difficult Substances and Mixtures OECD Paris Opperhuizen A Van der Velde E W Gobas F A P C Liem A K D Van der Steen J M D Hutzinger O 1985 Relationship between bioconcentration in fish and steric factors of hydrophobic chemicals Chemosphere 14 1871 1896 642 Opperhuizen A 1986 Bioconcentration of h
579. entration of surfactants RITOX the Netherlands 9 Nov 1993 Procter and Gamble Report ed M Stalmans Tolls J 1998 Bioconcentration of surfactants Ph D Thesis Utrecht University Utrecht The Netherlands Toshima S Moriya T Yoshimura K 1992 Effects of polyoxyethylene 20 sorbitan monooleate on the acute toxicity of linear alkylbenzenesulfonate Ci2 LAS to fish Ecotoxicol Environ Safety 24 26 36 USEPA 1985 U S Environmental Protection Agency Office of Toxic Substances Toxic Substances Control Act Test Guidelines 50 FR 39252 US EPA EC 1993 US EPA EC Joint Project on the Evaluation of Quantitative Structure Activity Relationships 543 US EPA 1996 Ecological effects test guidelines OPPTS 850 1000 Special considerations for conducting aquatic laboratory studies Public Draft EPA712 C 96 113 United States Environmental Protection Agency http www epa gov opptsfrs home testmeth htm Van Den Berg M Van De Meet D Peijnenburg W J G M Sijm D T H M Struijs J Tas J W 1995 Transport accumulation and transformation processes In Risk Assessment of Chemicals An Introduction van Leeuwen C J Hermens J L M eds Dordrecht NL Kluwer Academic Publishers 37 102 Wakabayashi M Kikuchi M Sato A Yoshida T 1987 Bioconcentration of alcohol ethoxylates in carp Cyprinus carpio Ecotoxicol Environ Safety 13 148 163 Wofford H W C D Wilsey G S Neff C S Giam amp J M
580. g 9C 2 11 12 P420 2 8 A B C D E F 2 11 1 2 2 15 A B C D E F P422 2 9 1 2 10 1 ey 2 12 1 2 3 P404 oar 3 1 1 2 3 BE DER EA AUKE IEA amp pag 3 Wt BIE ERIE Ch EGE 3 8 3 8 8 29 1 2 3 4 5 P403
581. ie Narkose Lipnick 1991a SR Meyer Overton n QSAR 1972 Pde A E au HRC gt 8s He Zs 3 By JERAT BFR 5 pi
582. iron Qual 20 425 435 Boethling R S PH Howard J A Beauman amp M E Larosche 1995 Factors for intermedia extrapolation in biodegradability assessment Chemosphere 30 4 741 752 de Henau H 1993 Biodegradation In P Calow Handbook of Ecotoxicology vol I Blackwell Scientific Publications London Chapter 18 pp 355 377 EC 1996 Technical guidance documents in support of the Commission Directive 93 67 EEC on risk assessment for new notified substances and the Commission Regulation EC No 1488 94 on risk assessment for existing substances European Commission Ispra 539 ECETOC 1998 QSARs in the Assessment of the Environmental Fate and Effects of Chemicals Technical report No 74 Brussels June 1998 Federle T W S D Gasior amp B A Nuck 1997 Extrapolating mineralisation rates from the ready CO2 screening test to activated sludge river water and soil Environmental Toxicology and Chemistry 16 127 134 Langenberg J H W J G M Peijnenburg amp E Rorije 1996 On the usefulness and reliability of existing QSBRs for risk assessment and priority setting SAR and QSAR in Environmental Research 5 1 16 Loonen H F Lindgren B Hansen amp W Karcher 1996 Prediction of biodegradability from chemical structure In Peijnenburg W J G M amp J Damborsky eds Biodegradability Prediction Kluwer Academic Publishers MITI 1992 Biodegradation and bioaccumulation data on existing data based on th
583. ity of existing QSARs for risk assessment and priority setting SAR QSAR Environ Res 5 1 16 R L Lipnick 1986 Charles Ernest Overton Narcosis studies and a contribution to general pharmacology Trends Pharmacol Sci 7 161 164 R L Lipnick 1989a Hans Horst Meyer and the lipoid theory of narcosis Trends Pharmacol Sci 10 7 July 265 269 Erratum 11 1 Jan 1990 p 44 R L Lipnick 1989b Narcosis electrophile and proelectrophile toxicity mechanisms Application of SAR and QSAR Environ Toxicol Chem 8 1 12 R L Lipnick 1990 Narcosis Fundamental and Baseline Toxicity Mechanism for Nonelectrolyte Organic Chemicals In W Karcher and J Devillers eds Practical Applications of Quantitative Structure Activity Relationships QSAR in Environmental Chemistry and Toxicology Kluwer Academic Publishers Dordrecht The Netherlands pp 129 144 R L Lipnick ed 1991a Charles Ernest Overton Studies of Narcosis and a Contribution to General Pharmacology Chapman and Hall London and Wood Library Museum of Anesthesiology R L Lipnick 1991b Outliers their origin and use in the classification of molecular mechanisms of toxicity Sez Tot Environ 109 110 131 153 R L Lipnick 1995 Structure Activity Relationships In Fundamentals of Aquatic Toxicology 2nd edition G R Rand ed Taylor amp Francis London 609 655 544 Loonen H Lindgren F Hansen B Karcher W Niemela J Hiromatsu
584. ls to the fathead minnow Pimephales promelas Narcosis and proelectrophile activation Xenobiotica 19 5 555 565 5 Brown D S and Allison J D 1987 MINTEQA1 Equilibrium Metal Speciation Model A user s manual Athens Georgia USEPA Environmental Research Laboratory Office of Research and Development OECD 1998 Harmonized Integrated Hazard Classification System for Human Health and Environmental Effects of Chemical Substances Document ENV JM MONO 2001 6 OECD 2000 Guidance Document on Aquatic Toxicity Testing of Difficult Substances and Mixtures OECD 2001 Guidance Document on Transformation Dissolution of Metals and Metals Compounds in Aqueous Media Santore R C and Driscoll C T 1995 The CHESS Model for Calculating Chemical Equilibria in Soils and Solutions Chemical Equilibrium and Reaction Models The Soil Society of America American Society of Agronomy Santore R C and Di Toro D M et al 1999 A biotic ligand model of the acute toxicity of metals II Application to fish and daphnia exposure to copper Environ Tox Chem Submitted Skeaff J Delbeke K Van Assche F and Conard B 2000 A critical surface are concept for acute hazard classification of relatively insoluble metal containing powders in aquatic environments Environ Tox Chem 19 1681 1691 Tipping E 1994 WHAM A computer equilibrium model and computer code for waters sediments and soils
585. mation of chemical in water OECD GD 97 21 Paris OECD 1998 Harmonized integrated hazard classification system for human health and environmental effects of chemical substances Paris Document ENV JM MONO 2001 6 Pedersen F H Tyle J R Niemela B Guttmann L Lander amp A Wedebrand 1995 Environmental Hazard Classification data collection and interpretation guide for substances to be evaluated for classification as dangerous for the environment Nordic Council of Ministers 2nd edition TemaNord 1995 581 166 pp Schwarzenbach R P P M Gschwend amp D M Imboden 1993 Environmental organic chemistry 1st ed John Wiley amp Sons Inc New York Scow K M 1982 Rate of biodegradation In Lyman WJ W F Reehl amp D H Rosenblatt 1982 Handbook of Chemical Property Estimation Methods Environmental Behaviour of Organic Compounds American Chemical Society Washington DC ISBN 0 8412 1761 0 Chapter 9 Struijs J amp R van den Berg 1995 Standardized biodegradability tests Extrapolation to aerobic environments Wat Res 29 1 255 262 Syracuse Research Corporation Biodegradation Probability Program BIOWIN Syracuse N Y http esc syrres com esc1 biodeg htm Westermann P B K Ahring amp R A Mah 1989 Temperature compensation in Methanosarcina barkeri by modulation of hydrogen and acetate affinity Applied and Environmental Microbiology 55 5 1262 1266 540 3 DE Anliker R M
586. ng of sparingly soluble volatile and unstable substances ECETOC Monograph No 26 ECETOC Brussels European Commission 1996 Technical Guidance Document in support of Commission Directive 93 96 EEC on Risk Assessment for new notified substances and Commission Regulation EC No 1488 94 on Risk Assessment for Existing Substances Brussels Ghose A K Prottchet A Crippen G M 1988 J Computational Chem 9 80 90 Gobas F A P C Opperhuizen A Hutzinger O 1986 Bioconcentration of hydrophobic chemicals in fish Relationship with membrane permeation Environ Toxicol Chem 5 637 646 541 Gobas FA P C Clark K E Shiu W Y Mackay D 1989 Bioconcentration of polybrominated benzenes and biphenyls and related superhydrophobic chemicals in fish Role of bioavailability and elimination into feces Environ Toxicol Chem 8 231 245 Goodrich M S Melancon M J Davis R A Lech J J 1991 The toxicity bioaccumulation metabolism and elimination of dioctyl sodium sulfosuccinate DSS in rainbow trout Oncorhynchus mykiss Water Res 25 119 124 Hansch C Leo A 1979 Substituent constants for correlation analysis in chemistry and biology Wiley New York NY 1979 Henderson R J Tocher D R 1987 The lipid composition and biochemistry of freshwater fish Prog Lipid Res 26 281 347 Howard P H and Meyland W M 1997 Prediction of physical properties transport and degradation for environmental fate and exposure
587. nmental Toxicology 22 26 May 1988 Knoxville Tennessee pp 91 98 Available from the National Technical Information Service US Dept of Commerce Springfield VA Schrap S M Opperhuizen A 1990 Relationship between bioavailability and hydrophobicity reduction of the uptake of organic chemicals by fish due to the sorption of particles Environ Toxicol Chem 9 715 724 Shiu WY Doucette W Gobas FAPC Andren A Mackay D 1988 Physical chemical properties of chlorinated dibenzo p dioxins Environ Sci Technol 22 pages 651 658 Sijm D T H M van der Linde A 1995 Size dependent bioconcentration kinetics of hydrophobic organic chemicals in fish based on diffusive mass transfer and allometric relationships Environ Sci Technol 29 2769 2777 Sym D T H M Part P Opperhuizen A 1993 The influence of temperature on the uptake rate constants of hydrophobic compounds determined by the isolated perfused gill of rainbow trout Oncorhynchus mykiss Aquat Toxicol 25 1 14 Spacie A Hamelink J L 1982 Alternative models for describing the bioconcentration of organics in fish Environ Toxicol Chem 1 309 320 Suzuki T Kudo Y J 1990 J Computer Aided Molecular Design 4 155 198 Syracuse Research Corporation 1999 Tas J W Seinen W Opperhuizen A 1991 Lethal body burden of triphenyltin chloride in fish Preliminary results Comp Biochem Physiol 100C 1 2 59 60 Tolls J amp Sijm D T H M 1993 Bioconc
588. oe ee FI 4 h OVER 4IZZAT B A9 7 5 3 3 1 _ 24 L E Cso ZI oe a L E Cs0 100 mg l NN 4 612 7 A9 7 5 3 3 2 7 7 a b c A9 7 5 3 3 3 A9 7 5 3 3 2
589. ogy ASTM 1979 vol ASTM STP 667 Connell D W Hawker D W 1988 Use of polynomial expressions to describe the bioconcentration of hydrophobic chemicals by fish Ecotoxicol Environ Saf 16 242 257 Connell D W 1990 Bioaccumulation of xenobiotic compounds Florida CRC Press Inc pp 1 213 De Bruijn J Busser F Seinen W amp Hermens J 1989 Determination of octanol water partition coefficients with the slow stirring method Environ Toxicol Chem 8 499 512 Devillers J Bintein S Domine D 1996 Comparison of BCF models based on log P Chemosphere 33 6 1047 1065 DoE 1996 Guidance on the aquatic toxicity testing of difficult substance Unites Kingdom Department of the Environment London Doucette W J Andren A W 1987 Correlation of octanol water partition coefficients and total molecular surface area for highly hydrophobic aromatic compounds Environ Sci Technol 21 pages 821 824 Doucette W J Andren A W 1988 Estimation of octanol water partition coefficients evaluation of six methods for highly hydrophobic aromatic compounds Chemosphere 17 pages 345 359 Driscoll S K McElroy A E 1996 Bioaccumulation and metabolism of benzo a pyrene in three species of polychaete worms Environ Toxicol Chem 15 8 1401 1410 ECETOC 1995 The role of bioaccumulation in environmental risk assessment The aquatic environment and related food webs Brussels Belgium ECEOOC 1996 Aquatic toxicity testi
590. oser P Poppinger D 1988 Bioaccumulation of dyestuffs and organic pigments in fish Relationships to hydrophobicity and steric factors Chem 17 8 1631 1644 Bintein S Devillers J and Karcher W 1993 Nonlinear dependence of fish bioconcentration on 7 octanol water partition coefficient SAR and QSAR in Environmental Research Vol 1 pp 29 39 Black M C Millsap D S McCarthy J F 1991 Effects of acute temperature change on respiration and toxicant uptake by rainbow trout Salmo gairdneri Richardson Physiol Zool 64 145 168 Bodor N Huang M J 1992 J Pharm Sci 81 272 281 Broto P Moreau G Vandycke C 1984 Eur J Med Chem 19 71 78 Chiou T 1985 Partition coefficients of organic compounds in lipid water systems and correlations with fish bioconcentration factors Environ Sci Technol 19 57 62 CLOGP 1995 Daylight Chemical Information Systems Inf Sys Inc Irvine Ca CSTEE 1999 DG XXIV Scientific Committee for Toxicity and Ecotoxicity and the Environment Opinion on revised proposal for a list of Priority substances in the context of the water framework directive COMMs Procedure prepared by the Frauenhofer Institute Germany Final report opinion adopted at the 11 CSTEE plenary meeting on 28 of September 1999 Comotto R M Kimerle R A Swisher R D 1979 Bioconcentration and metabolism of linear alkylbenzenesulfonate by Daphnids and Fathead minnows L L Marking R A Kimerle Eds Aquatic Toxicol
591. regor Pratt and Obadia 1989 Evaluation of the developmental toxicity of Globalene Hazexyl Systemol in Fischer 344 rats and New Zealand White rabbits Fundamental and Applied Toxicology Etc 463 464 9 464 A9 1 FF 9 A9 2 A9 2 1 A9 2 2 A9 2 3 A9 2 4 A9 2 5 A9 2 6 Db A9 3 A9 3 1 FE A9 3 2 A9 3 8 A9 3 4 A9 3 5 A9 3 6 A9 4 A9 4 1 FE A9 4 2 A9 4 8 WE A9 4 4 A9 5 A9 5 1 FE A9 5 2 A9 5 3 BCF K A9 5 4 A9 5 5 A9 6 QSAR A9 6 1 A9 6 2
592. s0 iB Fi v Xa KAIRE ko CAA aT 33 E L E Cs0 2 E 3 7K E E E 4 A x4 NOEC A9 7 5 4 TIE E KIA A9 7 5 4 1 E 3 v 3 4 E
593. sation for Economic Co operation and Development April 2001 549 OECD Environment Health and Safety Publications Series on Testing and Assessment No 29 Environment Directorate A10 2 2 A10 2 2 2 BYL PHEO RZ Y TRE EES A10 2 2 1 E 100mg 24 24 A10 2 8 BYL BMFOREMAR BBL EG EERIELS A10 2 3 1 A
594. ublic Drafts 850 1000 Special consideration for conducting aquatic laboratory studies 850 1000 Special consideration for conducting aquatic laboratory studies 850 1010 Aquatic invertebrate acute toxicity test freshwater daphnids 850 1010 Aquatic invertebrate acute toxicity test freshwater daphnids 850 1020 Gammarid acute toxicity test LLEFOY E2000 E9 FUE OE OCHO BLU GT BIL ORM amp SVVLEO MBOHBNSE CC EHKI LEFT ELER b BS 635 850 1020 Gammarid acute toxicity test 850 1035 Mysid acute toxicity test 850 1035 Mysid acute toxicity test 850 1045 Penaeid acute toxicity test 850 1045 Penaeid acute toxicity test 850 1075 Fish acute toxicity test freshwater and marine 850 1075 Fish acute toxicity test freshwater and marine 850 1300 Daphnid chronic toxicity test 850 1300 Daphnid chronic toxicity test 850 1350 Mysid chronic toxicity test 850 1350 Mysid chronic toxicity test 850 1400 Fish early life stage toxicity test 850 1400 Fish early life stage toxicity test 850 1500 Fish life cycle toxicity 850 1500 Fish life cycle toxicity 850 1730 Fish BCF 850 1730 Fish BCF 850 4400 Aquatic plant toxicity test using Lemna spp Tiers I and II 850 4400 Aquatic plant toxicity test using Lemna spp Tiers I and II 850 4450 Aquatic plants field study Tier III 850 4450 Aquatic plants field study Tier ITI 850 5400 Algal toxicity Tiers I and II 850 5400 Algal toxicity Tiers I and II 3
595. ydrophobic chemicals in fish In Poston T M Purdy R eds Aquatic Toxicology and Environmental Fate Ninth Volume ASTM STP 921 American Society for Testing and Materials Philadelphia PA 304 315 Opperhuizen A Schrap S M 1987 Relationship between aqueous oxygen concentration and uptake and elimination rates during bioconcentration of hydrophobic chemicals in fish Environ Toxicol Chemosphere 6 335 342 Opperhuizen A Sijm D T H M 1990 Bioaccumulation and biotransformation of polychlorinated dibenzo p dioxins and dibenzofurans in fish Environ Toxicol Chem 9 175 186 Pedersen F Tyle H Niemel J R Guttmann B Lander L and Wedebrand A 1995 Environmental Hazard Classification data collection and interpretation guide 2nd edition TemaNord 1995 581 Petersen G I Kristensen P 1998 Bioaccumulation of lipophilic substances in fish early life stages Environ Toxicol Chem 17 7 1385 1395 Rekker R F de Kort H M 1979 The hydrophobic fragmental constant An extension to a 1000 data point set Eur J Med Chem Chim Ther 14 479 488 Roberts D W 1989 Aquatic toxicity of linear alkyl benzene sulphonates LAS a QSAR analysis Communicaciones Presentadas a las Jornadas del Comite Espanol de la Detergencia 20 1989 35 43 Also in J E Turner M W England T W Schultz and N J Kwaak eds QSAR 88 Proc Third International Workshop on Qualitative Structure Activity Relationships in Enviro

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