No.1606 - 国立病院機構 仙台医療センター
Contents
1.2.
3.
4. 3 4 3 4 3 4 CYP 3 4 CYP 3 4 P P
5. HIV po0000000000000000000 0000000000000 00 00000 po8000000000
6. Iil 71 39 54 9 32 494 ALT 1 4 Y GTP 1 4 1 4 1 4 oooo0000000000000000000
7. 75 3900 52 0 9 3 9 3 4 0 4 0 4 0 91 4 48 4 1000 11 0 1000 11 0 7 7 5 5 40 0 20 0 20 0 0000000
8. 1500ny 1500ny DO00g gg 000000000 0000000 00000000 000 000000 DSM 1 DS American Psychiatric Associati
9. 0000 0000 000000000000000000 Cmex 2494 4494 000000000000 000000000000000 2015 4 DSU No 238 CA ATAN 000000
10. HIV 300ny I 300 100ny 22 I 600 100mg 100 37 300 100 600ny AUC 13 21 I 400 100ny 200ny 27 CYP3A4 800 100ny 150 130 CYP3A4
11. 19606 600 100ny 35u g lny AUC 44 1406 800 100mg 50mg 150mg 2 6 CYP3A4 CYP3A4 CYP3A4 2015 4 DSU N
12. 0000 0000000000000000000 HCV RNA Dd gg 000000000000 00000 000000480 000118 008 000000 0000 0000 0000000000000000000 HCV RNA A S 000 000000 0000 0000 000000000000000000 800 000000000000000000
13. 500mg 45 A AA EAN 000000000000000 0000000000000 2015 4 DSU No 238 SA poo 2000090 0000
14. P450 CYP3A4 CYP3A4 CYP3A4 CYP3A4 CYP3A4 2015 4 DSU No 238 St ohn s Wort
15. 000g 0000 I 818 556 426 52 1 16100 19 7 10400 12 7 6200 7 6 5500 6 7 4900 6 0 4300 5 3
16. 0000 648 502 77 594 25400 39 294 218 33 6 200 30 9 1977 11 253 176 69 6 130 51 4 98 1 38 794 23 9 1 ALT GPT AST GOT
17. 62 125 6200 33 2 4100 21 9 2000 10 7 3 7 3 2 2 1 1 1 1 194 253 69 694 130 51 494 98 38 794 23 9 194 22 8 794 28 11 194 13 5 1 12 11 4 7 8 3 2
18. poo 90D 2 4320 148 6 09 1979 1983 19 884 39600 1 99 22 3160 544 2 44 1 119 17500 0 78 AST GOT 15200 0 68 ALT GPT 143 0 64 120 0 54 66 1 0 30 4gx 102 1 4 1 43 1 54 1700 16 7 6 9 Y GTP 5 9 100my kg x 21 42 9 15 28 6 ALT GPT 14 3 AST GOT 9 5 2015 4 DSU 238
19. ooo 00000000 CARA a 156 4 998 627 CRP CK CPK 2015 4 DSU No 238 CA A a 020 00000000 0000
20. 5 5 5 500mg 4594 00000000000000 000000000000000 C oo oo o o oo o og poo 0000 aaa a 0000000000000 000 2015 4 DSU No 238
21. 000000000000000000 LLLI 178 85 7 457 533 53 851 287 39 651 211 32 1 171 31 051 165 28 1 150 26 5 141 23 6 126 20 1 107 19 9 106
22. CYP3A4 CYP3A4 CYP3A4
23. 0000 000 000000000000000000 16 16 15 18 8 6 3 LLLI 71 39 54 9 32 494 ALT 1 4 Y_ GTP 1 4 1 4 1 4 2015 4 DSU No 238 00000000000000000000000000 ea ao a a aaa daa daa da 000 0000000
24. c pod 0000 0000000000000 0000000000000 egodo0000000000000000000000000 0000000000000 00000000000 2015 4 DSU No 238
25. i m m CYP3A P c 00000000 codo000000000000 00000000000000000006 20000000000000000 cod00000000000000000 egog0000000000000 op 0 000 0000000000000 0000000000 D00000000000000000000 0000000000000 00000 Ei aaa a o 0000 0000 000000000000000000
26. A A o oo onoo ao m o E Eo a o E o E a o aa 00000000 009004008 0019 00 4808 0000 1608 45200 28 1 2640 016 4 640 04 0 50 3 1 260 01 6 150 0 9 ALT GPT 15 0 9 140 00 9 498 52 10 494 44 8 894 4 0 8 000 O O
27. 0000 45 10 22 2 4 4 2 2 239 00000A 690 28 87410 111 LOOT 5 20 92 1 67 SGA 67 23 34 394 7 594 6 094 6 094 890 44 4 94 0 45 0 34 CK 0 34 0 34 0 34 2015 4 DSU 238 CA
28. 0000000000 00000 c 000000000000 0 20mgl poo 0000000000 AA AA 0000
29. 2015 4 DSU No 238 E 000000 a aaa ada 0000 000000 5 45 PDE5 tua NAION
30. 0000000000000 000 EA 000 000000000
31. 2015 4 DSU 238 E cpodoo000000000025mgl 50mgl 450 3 4 50 45 PDE5 tuy2 NAION
32. 0000000000000 Aa 000 00000000 0000 LLLI 240 31 21900 91 3 13000 54 2 126 52 5 11600 48
33. AO 0000 0000 000 Ez 000000000000000000 000000000000000000 20mg 20mg 2015 4 DSU No 238
34. aaa 000 00000 EE e 0000000000000 000000 5 D o oo Aa poo 009000 ara a DODO CK CPK 00000000000000 0000000000000000 a 000 00000000 2015 4 DSU No 238 a aa aa aaa aaa 000 00000000 0000 000000000 000000000 Aaa OO a C Ooo 0 00 000 000000
35. 0000 00000 000000000000000000000 400 0000000 Doo 000 000000000000000 0000 000000000000000000 coa a a ace atada aa da apta 0000
36. 2015 4 DSU 238
37. 2015 4 DSU No 238 aa a rata PRSP MRSA MRCNS PRSP D0000000000000000000000Mejisek 0000 000000000000 0000000000000000000000 o aa
38. 2015 4 DSU No 238 capa aaa ta poo 0000000000 0000 436 436 119 27 394 235 5 5 24 436 3 9 17 436 2 3 10 436 AST GOT 4 1 18 436 3 7 16 433 ALT GPT 3 0 13 436 1 111 53 48411961 LO 0 0 ASTI GOT 1 2 13 ALT GPT Y _ GTP 1 1 12
39. 2015 4 DSU No 238 ceoodo000000012 5mg ooo 00000 1 25700 2013 11 0000000000000 c 00000000000 50mg0 150mg ooo 00000 0000 0000 150 15mL 10my mL
40. 0000000000000 M0000000000000000 0000000000000 M00000000000 0000000000000 0 000000 00000000000 0000 00000000 0000000000000 0000000000000 M00000 ooo 0000 00000000000 000000000 000000000000 0000000000000 000000 0000000000000 0000000000000 M0000 CA O 800 00000000000 00000000 P 2015 4 DSU No 238 C Dopp o0 0 0 00 0 0 aa aa 000 00000000000000
41. 2015 4 DSU No 238 00008000000 0000000000000000M00000000000000000000000000 epa aa ao 0 8 000 000000000
42. CYP2D6 CYP3A4 CYP3A4 CYP3A4 CYP3A4 00000 po000 00000000 ooo 00000 MeijiSeikal D 0
43. CA an 000000
44. 2015 4 DSU No 238 3 4 3 4 CYP 3 4
45. CYP 3 4 P 3 4 p000000000000 000000 pg00000000000 0 0000000000000 pog0000800000000 000000 pg00000000000 0000000000000 0800000000000 0M000000000000000 po800000000000 000000 pg8000000000000000000 po80000000000000000000 po000 poadgo0000 00000000000 mod0 000000000000 modo00 pog00000000000000000 00000 0000000000 MeijiSeika 0 0 00 000
46. mod0 000000000000 modo 00000000 modo 0000 mod000 0 0000000000 MejjiSeika 0 0 00 000g 0000000000 O 000 000 000 000 000 000 000 000 000 000 0 000 0000 CAMA
47. 000000 00000000000000000 00000000000000000000 Saa a aa aa a ada dada 0000 NAAA 00000000000000000000000 ANT 0000 000
48. Diagnostic and Statistical Manual of Mental Disorders 000000000000000000 6 17 DSM IV 2015 4 DSU 238 ARENA CAE
49. ATEO No 1606 YHx27 4A10H ea ARRE 2 AMA E A E PARA 104 RAR ERMO MER ORD Drug Safety Update 237 2015 3 LIE TREX RO EREDA DUETINELAEOT 35 15311 8 lt 2 XH gt Drug Safety Update 2015 4 238 BEZIDE ERA 9 MIT DATE RS NEAR AA UE ERA Fah A EH RENE AAKRE 40mg 1mL 3 M2 7UVTF VARIA A AE TE 50mg 3 27 PA RO EA ADE 50mg EN AAA 100mg eere 3 TER TA hI p EE 200mg A AI Ai 3 CUBA COSITA Y ONE ea 4 ZO IN 4 GEO A 77 7 iE 500mg 7 7 5090 5 Mrs A A 5 BIRD 6 P gt 7UV gt VIa ME 25mg E E R ti E 6 EUA 352 n ANHI 1mg mL YZAYFY OD E Img 1 h DJ 7 7 gt 0 MER 12 5mg TNA Ha HA 12 5mg 8 770 MIRRA 50mg 150mg T272 AEH 50mg A E 8 27 20mg 8 MAA 9 My IATA 9 SS A 0 58 eeerrererrerseerssersersrrssrrsers 9 A E 9 Mi ho RR O O OS 10 A SISI 10 MITA TER AEH BAREA ERA UFI BEA BIRREA KERE 40mg 1mML eee 11 8 1 gt BERE
50. 1my kg Aa 000 0000000000 0000 0000 o000000000000000000 0000 ca aaa aaa 000
51. 26 MINT 9 22 800mg a 26 MAA H AMMIEDIF Y SAI E YI V SN 29 MEAR E EEES TT UT RERIK I EER EEIZ F A ee 29 77792 NARRE 250 TAX RENA 500mg 99 GI 200000000000000 0000 BO000000000000000000000000000000 0000 0000 ood00 00000 00000000000000000000 o00000 0000000000000000000000000
52. 600 100mg 30ny AUC 22 2015 4 DSU 238 CA A A AAA 000 00000 0000 000g 000080000000000000000000 CA 000 00000 0000 00000000000000000000000000 E E a
53. 00000000 000000000000 0000000000000 000000000000 000000000000 000000000000 C o o o o o o o o o o o oo o o a 000 200000 2 5my kg 5 1my kg 00000000000000 000000000000000000 C o o o o o o o ooo o o aaa 000 200000 2015 4 DSU No 238 5
54. 0000000000000000 0000000000 000000000000000 2015 4 DSU 238 adapte Pure
55. 3 9400 39 2 93 38 8 8200 34 2 7300 30 4 65 27 1 61 25 494 LLLI LLLI 844 29 79500 94 294 45100 53 4 36100 42 8 32400 38 4 29600 35 1 28600 33 9 27800 32 9 24400 28 994 18400 21 8 18100 21 4 17500 20 7 LLLI LLL LLLI 2015 4 DSU No 238 LDH 00000000000 00000000000 CA AA poo 00000000
56. CABRERA EN 11 11 BRZI ZINE QRR TAZIN RVV 11 OZ FED ae ria 12 MATT Rm Dm lc 13 ANY DINA O O 13 AA IOMA ER 250mg VZORKY 25m ITA 33 21117 25mg 14 MORATA RARO E RADA E 5 ERA RE 100mg 15 Min ESA RAY MES ARR 41 10mg 50mglNK 16 3 A Img A A E E E 16 2 AMENE D0mg 100mg 200mg 17 ETO FESE APSA RE 18 NU TA iE 200mg O OO OOO 18 7 3D CERTAIN ZLE 50mg 19 MT AV ARA CERA COME SAIZ AA 0 5 20 BENII FRA A ARA E 16g OME AA TIRA eres 20 MY AA SARAAN vav 2g E E 21 EVA EEA ORO 21 74 IF MINI BEAT E ses anos 91 MEA 91 91 MATAR RAS RAH 91 A ORMA ZIVA RE 50 W ZZV RINA 23 VIVA RKR IFRA 24 TERANA RKR IFRA AA 24 7 A TERANA KRH APA AY Sy crrrrnn ran ran ran ran ran rara ran raras 98 TERANA IRR e R ODAS p 25 96 77 7 E
57. g 0 0000000000000 0 0 O 0 00 mm N 5 gt n a N ea e a a a a a a a a a a a a c aa
58. o 238
59. poeg0000 000000 000000000000000000 pod00000000000000 po000000000000000000 pedo do 00 000000000 000000000000000 pogo0dB00 0000000 0000000000000 0000000000000000 po000000000000000000000 poed000000000000000000000000000 pog0000000000000 000000 po000000000000000000000000 pod000000000000000000000 odo0o000 0000000000000 0000000000 000000000 DOD00 000 0000000000000 pog0000000000000000 0000000000000 pog00000000000 poed00000 0000000000000 0000000000 2015 4 DSU No 238
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