ナノキャリア（4571）
Contents
1.2. a i sh ared esearch z http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved VA 4571 SR Research Report 2015 8 7
3. 100nm EL L EPR Enhanced
4. 2015 3 2015 3 12 389 400 1 1 284 ale E32 ODER 499 989 600 494 989 600 T
5. 2014 11 2014 11 11 2015 3 2015 3 560 330 e ZRK 1 428 1 955 1 029 1 929 1 070 1 970
6. a i sh ared esearch z http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved VA 4571 SR Research Report 2015 8 7
7. DIC TOKAL
8. 2015 1 a i sh ared Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved VA 4571 SR Research Report 2015 8 7 2014 6 E7974 DR E7974 ADCM E7974 2015 2 si
9. 2 202 ADA 109 0 NC 6004 OEP I b I Basket design trial 2016 3 I I
10. NC 6004 Sh ared Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved VA 4571 SR Research Report 2015 8 7 NC 6004 I NC 6004 NC 6004 2 2015 5 14 2015 3
11. JE 211 224 16 ih Shared Mesearch http www sharedresearch p Copyright C Shared Research Inc All Rights Reserved 66 85 z VA 4571 SR Research Report 2015 8 7 2015 3 2015 3 330 2014 3
12. NK105
13. NC 6004 NC 6004 I II OEP I II 2013 6 NC 6004 I II
14. DDS Sh ared esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved VA 4571 SR Research Report 2015 8 7 2o11 16 3 7 133 AR 46 696 23k 393 4 3 794 37 1 1 6 268 15 2011 15 Zoladex AstraZeneca
15. siRNA 3 NanoFect NanoFect A Sh ared KMesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved VA 4571 SR Research Report 2015 8 7 201080038549 X 2015 2 2015 2 24 2015 3 2015 3 673 560 e ZRK 1 127 1 428
16. 2014 3 NC 6004 NC 4016 siRNA ADCM 2013 3 238 2014 3 926 2015 3 1 053 2016 3 2 202 2013 10 9 069 2013 11 2018 10
17. QOL Quality of Life NC 6004 NC 6004 2006 5 T
18. 2011 9 290 Sh atrodi escar ch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved VA 4571 SR Research Report 2015 8 7 07 3 08 3 09 3 10 3 11 3 12 3 13 3 14 3 103 263 354 118 84 346 374 472 676 4 1 154 0 34 6 66 7 28 4 310 7 7 9 26 3 43 1 92 68 247 71 51 125 273 182 212 12 194 106 47 33 221 101 290 464 11 3 74 0 30 1 39 8 39 4 63 9 27 0 61 496 68 796 729 647 638 540 553 555 628 1 413 1 572 704 8 246 2 180 4 458 0 655 9 160 2 167 9 299 2 232 6 717 453 532 493 52
19. A 3 000nm 300nm 100nm 100nm
20. Tissue Factor TF TF TF TF ADCM Antibody Drug conjugated Micelle
21. a i sh ared Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved VA 4571 SR Research Report 2015 8 7 110 ZEIA ABe 2015 3 1 ABa 84 2015 3 2 431 2015 3 2 346
22. SR Inc SR tnc 3 31 12 tBadtr 03 5834 8787 http www sharedresearch p Email info sharedresearch jp ji Sh ared Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved
23. OEP NC 6004 NC 6004 OP Nano OP Nano GMP Good Manufacturing Practice ZETU e OP Nano OP Nano F N ni null gt NT 1 000 2016 12 8 900m lt Huwei Yunlin
24. 20 100 tV okl ELS ABA 180nm 1800nm 4000nm 7300nm 8000nm SEM ZR 20 100nm 20 100 nm a Sh ared Gcsearch http Www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved VA 4571 SR Research Report 2015 8 7
25. COO 1 4502
26. ADCM siRNA Active NanoFect 1 1 2014 5 ADOM a i sh ared esearch z http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved VA 4571 SR Research Report 2015 8 7 t79 l E853E9 58 RH Active Targeting 3 a Mh S n WW E7974 2014 6 1 4523 E7974
27. 2013 9 24 NC 6004 NC 6004 Orient Europharma Co Ltd OEP OEP t 2
28. NK105 FLATI 2 E U Tz 98 I 2010 8 LTBBRPREIUSS 2012 7 III II ITI NK105 380 2 2015 F 2016 3 NDA New Drug Application NK105
29. 1 1 3 2 a Shared Mesearch http Www sharedresearch jp Copyright C Sha
30. siRNA siRNA NanoFect 2013 6 siRNA siRNA 3 2013 6 NanoFect
31. Basket design trial 2016 3 I I II a i sh ared Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved VA 4571 SR Research Report 2015 8 7 1
32. 2015 1 2015 1 29 pH pH pH NC 6300 K 912 T NC 6300 K 912
33. Sh atrodi esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved VA 4571 SR Research Report 2015 8 7 2016 3 16 3 15 3 16 3 E173 P3 676 137 43 1 79 7 212 464 60 096 68 7 1 572 7G EESHRERENEIEXE 232 696 1 108 2 666 E 6 171 2 617 6 207 2 772 SR 137 79 7 2 666 ADA 1 108 2 617 ADMA 171 2 772 207
34. c MediCelle Debiopharm 2011 3 2005 3 Debiopharm S A NC 4016 2009 3 Uic TOR Debiopharm I 2011 3 Debiopharm 1 a i sh ared ese
35. NC 6300 2011 9 NC 6300 K912 NC 6300 K912 24 I 2013 5 NC 6300 K912 IND
36. T an DNA O RNA mi rog 5 a i sh ared Mesearch http
37. SR NC 4016 2 272 2007 EvaluatePharma 1 100 NC 6300 K 912 DNA DNA NC 6300 K912 pH
38. RNA RNA RNAi RNA 20 RNA tRNA RNA rRNA U a i sh ared Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 1 ua VA 4571 SR Research Report 2015 8 7 RNA 300 20 10 300 DNA RNA
39. OEP NC 6004 ASRAB NC 6004 NC 4016 ADCM Antibody Drug Conjugated Micelle siRNA NanoFect ADCM Active NanoFect
40. pH NC 6300 K912 Sh ared Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved VA 4571 SR Research Report 2015 8 7 Improved anti tumor activity of stabilized anthracycline polymeric micelle formulation NC 630 M Harada I Bobe H Saito N Shibata R Tanaka T Hayashi Y Kato Cancer Science 102 1 192 199 2011
41. 2 MediCelle 3 NanoCoat http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved VA 4571 SR Research Report 20
42. NC 6004 Orient Europharma Co Ltd I b I gRSBEDZ A 1 T TL Sh atrodi esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved
43. 2011 9 NC 6300 2012 3 1 4523 2012 3 1 700 2 025 usce aided csi ie aint N e E
44. NC 6004 Orient Europharma Co Ltd AF OEP Phase I OEP OP Nano NC 6004 2016 2014 6 23 1 4523 E7974 F m Shared esearch http Wwww sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 64 85 VA 4571 SR Research Report 2015 8 7
45. a i sh ared esearch z http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 1 ua VA 4571 SR Research Report 2015 8 7 Do 1 nm 10 482300 1 DDS Drug Delivery System
46. ADCM Antibody Drug Conjugated Micelle E7974 ADCM 10 E7974 ANM ze UY
47. NC 4016 NC 4016 3 amp a i sh ared Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved VA 4571 SR Research Report 2015 8 7 15 3 150 176 119 28 57 254 47 317 100 1 675 1430 2 96 4 16 7 83 9 62 0 44 79 60 1 1040 8 42 9 98 125 53 14 27 177 9 251 209 999 14 9 51 1 72 4 41 2 82 9 1747 1 65 2 71 49 44 8 48 9 47 49 69 6 19 2 79 1 REE 375 349 336 352 409 303 423 437 151 8 172 2 114 690 81 996 8 9 13 3 25 8 24 296 2
48. a P Sh ared esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved VA 4571 SR Research Report 2015 8 7 2014 3 2014 3 OEP 195 103 100 ADA 233 130 472 ANA 26 3 688 926 1 123 2013 3 527
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51. 1J P Morgan Securities plc J P 5 460 6 300 l o JP i dJ P Morgan Securities plc 2013 11 22 2013 11 25 2013 9 30 364 352
52. ADCM Antibody Drug Conjugated Micelle 10 ADCM
53. NanoFect NanoFect a i sh ared esearch z http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved VA 4571 SR Research Report 2015 8 7 d 2014 5 2014 5 19 2014 4 2014 4 2
54. 2014 8 2014 8 20 NC 6004 NC 6004 NC 6004 NC 6004 are HA BAM RE SA NC 6004 2014 7 2014 7 16 pH pH
55. 800 OEP OEP OEP OEP 2013 9 OP Nano ft OP Nano 29 5 2016 12 2012 8 31 TFDA Taiwan Food and Drug Administration IDB Industrial Development Bureau Ministry of Economic Affairs
56. Johnson Matthey NCI Bristol Myers Squibb 2 DNA DNA 1983
57. 2013 5 I IND FR PMDA OR 1 4523 2012 3 2012 3 346 ADA 310 7 334 2011 3 520 366 ADA 2011 3 550
58. E7974 I 2015 5 2 IND Sh atrodi esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved VA 4571 SR Research Report 2015 8 7 siRNA siRNA small interfering RNA RNA mRNA RNA RNA DED siRNA siRNA
59. a i sh ared esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved VA 4571 SR Research Report 2015 8 7 d IND Investigational New Drug PFS Progression Free Survival http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved P 83 85 4571 03 3548 0213 1996 6 14 HP http www nanocarrier co jp IR IR info nanocarrierCO D http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved SR Research Report 20
60. ERDER ROEA aL DDS DDS GMP Good Manufacturing Practice TInternational Conference on Harmonization ICH Abraxis Bioscience Inc
61. Shared Researcn SR Inc SR Inc SR Inc SR Inc SR Inc
62. 2014 3 1 4403 65 681 32 8 34 230 17 196 30 000 15 096 25 900 12 996 TLO OST JST
63. siRNA a M Sh ared Mesearch a http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 1 ua VA 4571 SR Research Report 2015 8 7 2015 3 48 44 0 10 p PE1 7 25 6 24 3 67 rH 2 72 2 37 2 35 DEUTSCHE BANK AG LONDON PB NON TREATY CLIENTS 613 1 99 UBS AG LONDON A C IPB SE GREGATED CLIENT ACCOUNT 1 51 CYNTEC CO LTD 1 46 1 37 SR 2015 3 2015 3 aN i shared esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved VA 4571 SR Research
64. 2009 7007877 2014 7 14 NC 6004 NC 6004 2009208481 2014 6 2014 6 26 NC 6004 3 NC 6004 NC 6004
65. 2014 6 3 siRNA NanoFect SIRNA NanoFect 3 A
66. 28 000 e 2013 10 21 2013 10 23 0 90 1 00 X UIAGES e J P J P Morgan Securities plc 2013 10 28 2013 10 30 8 400 P E 1 7 700 700
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68. 2013 9 17 OEP OP Nano a i sh ared esearch z http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved VA 4571 SR Research Report 2015 8 7 NC 6004 Orient Europharma Co Ltd OEP fF OEP OP Nano 1 NT 29 500 000 NC 6004 OEP 2012 11 OP Nano
69. NC 6004 OEP 2014 2 2014 11 NC 6004 300 3 2017 2018 3 2018 F 2019 3 OEP
70. siRNA ADOM 2014 6 E7974 E7974 ADCM NanoFect
71. I 2013 9 ADCM Antibody Drug Conjugated Micelle SIRNA NanoFect 2013 6 2012 7
72. Active NanoFect siRNA Sh atrodi escar ch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved VA 4571 SR Research Report 2015 8 7 SR NK105 NC 6004 e NK105 NK105 2015
73. ADCM Antibody Drug Conjugated Micelle siRNA NanoFect DDS 2015 3 1 2015 3 1 57 150 a i sh ared Mesearch http www sharedresearch jp Copyright C Shar
74. Orient Europharma Co Ltd II 2013 2012 10 I 2013 Sh ared Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved VA 4571 SR Research Report 2015 8 7 NC 4016 T MD The University of Texas MD Anderson Cancer Center NC 6300
75. 2013 10 2013 9 o 2013 10 8 651 11 418 9 069 24 270 727 2013 3 2013 3 Orient Europharma Co Ltd 373 7 9 526 ADA 2012 3 m sh ared Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 44 o5 VA 4571 SR
76. ADCM Sh ared esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved VA 4571 SR Research Report 2015 8 7 ADCM
77. ED50 DNA DNA CHOP 0 Sh ared es
78. 3 a i sh ared Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved VA 4571 SR Research Report 2015 8 7 A 3 120 140nm B 30 50nm siRNA ATP E
79. NC 6004 2 272 2007 1 720 2008 905 f 2003 EvaluatePharma 1 100 NC 6004 19 800 NC 4016 NC 4016 War
80. http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved VA 4571 SR Research Report 2015 8 7 Orient Europharma Co Ltd UF OEP NC 6004 OEP 2012 11 H OEP OEP NC 6004 OEP OEP OEP
81. 346 NC 6004 5 a i sh ared esearch z http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved VA 4571 SR Research Report 2015 8 7 Orient Europharma Co Ltd
82. AMD siRNA siRNA siRNA 2010 9 2009 5 A 25 TLO
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86. J P Morgan Securities plc 6 300 840 Sh ared Kesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 69 85 ua VA 4571 SR Research Report 2015 8 7 5 460 JP P Morgan Securities plc P 840
87. 2015 3 2015 5 12 NC 4016 NC 4016 2016 3 gt 2013 3 21 2013 4 4 NC 4016 another process variation NC 4016
88. E7974 I E7974 ADCM Therapeutic index 30 E7974
89. HD SR Research Report SR Inc SR Inc
90. 9S ILTH SIH IND I 2012 10 I 20 2014 2015 3 2020 2021 3 I 2014 5 148 b 8 14 MD 80 2017 F 2018 3 2020 2021 3
91. NC 6004 2016 3 2015 6 10 2015 6 9 N C 6004 I JBBRPKaI IND NC 6004 I IND PMDA 6 9 2016 3
92. NanoFect ADCM NanoFect DDS 2015 1 2015 3 2 311 ADA 326 A 508 ADA 501 149 ADA 436 152 ADA 437 2
93. 225 211 1 095 ADA 432 1 114 ADA 484 NK105 1 4272 2012 7 NC 6004 Orient Europharma Co Ltd
94. 2015 3 1 599 Ei T 2014 6 2014 3 2014 3 18 Antibody Drug Conjugated Micelles Antibody Drug Conjugated Micelles ADCM a i sh ared esearch z http www sharedresearch jp Copyright C
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97. PEG F s Shared Mesearch http Wwww sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 40 85 VA 4571 SR Research Report 2015 8 7 Novosom AG
98. RT pi NC 6004 NC 4016 Sh ared Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved VA 4571 SR Research Report 2015 8 7 NC 6004 III 2012 3 2 4 1
99. TFDA Taiwan Food and Drug Administration 1 II a i sh ared Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved VA 4571 SR Research Report 2015 8 7 Hydration Hydration NC 6004 NC 6004 7
100. http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved VA 4571 SR Research Report 2015 8 7 CEO TR 1996 6 1997 8
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102. 3 2015 5 NC 6004 NC 4016 2 Sh ared escar ch http Www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved VA 4571 SR Research Report 2015 8 7 3 siRNA 3 1 2
103. 1 118 2015 2 24 DDS siRNA siRNA a i sh ared Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved VA 4571 SR Research Report 2015 8 7 active NanoFect siRNA
104. QOL http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved VA 4571 SR Research Report 2015 8 7 DDS UNES C 60 DDS amp Abraxis Bioscience Nasdaq ABII DDS 2005 AstraZeneca
105. DDS SP1049C 2005 II HARAN CE NanoBiotix a i sh ared Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved VA 4571 SR Research Report 2015 8 7
106. OEP 2014 1 IND Phase 2013 12 H 17 2013 10 2013 10 21 2013 10 7 a i sh ared esearch z http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved VA 4571 SR Research Report 2015
107. pH pH DDS ADCM Antibody Drug conjugated Micelle 2014 12 2014 12 12 2015 1 1 2013 10 a i sh ared Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved VA 4571 SR Research Report 2015 8 7
108. I 2013 12 MD Anderson NC 6300 I 2013 9 NK105 1 4272 2012 7 a i sh ared Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved VA 4571 SR Research Report 2015 8 7 ADCM Antibody Drug Conjugated Micelle
109. 2014 2 NC 6004 2014 6 amp 2015 4 2015 4 3 2015 3 2016 3 2015 3 675 673 2K 1 129 1 127 189 285 227 322 1 118
110. 2014 3 2 285 2 19 278 21 563 2014 3 402 652 5 08 http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved VA 4571 SR Research Report 2015 8 7 07 3 08 3 09 3 10 3 11 3 12 3 13 3 14 3 GEDAM CF A 663 588 457 452 578 293 635 1 098 1 121 CF B 62 19 4 8 5 1 721 121 7 059 2 562 FCF A B 725 607 461 460 582 2 015 757 8 158 3 683 CF 1 143 643 75 97 1 449 1 924 2 327 9 581 505 A 8 15 16 16 16 18 7 5 19 B 11 14 3 2 4 19 20 27 166 C 6 78 71 29 48 30 41 54 81
111. MG 1980 CFO Chief Financial Officer RAEk 2015 6 H 2014 12 2015 1 CFO 381ERZE DDS
112. TF ADCM Tissue Factor 1 Tissue Factor 2015 7 27 B hi DDS NanoFect siRNA a i sh ared Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 1 ua VA 4571 S
113. 62 19 4 8 5 1 721 121 7 059 2 562 ano o 1 143 643 97 1 449 1 924 2 327 9 581 505 42 7 24 4 29 3 37 0 34 6 12 8 9 3 11 0 1 2 ROE 52 2 26 9 31 2 40 0 38 8 21 5 15 6 12 4 1 5 88 3 93 3 95 496 89 496 90 796 50 796 78 596 94 896 98 696 SR Shared esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved VA 4571 SR Research Report 2015 8 7 x 2015 8 7 Tissue Factor 2015 8 6 Tissue Factor
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119. E7974 ADCM siRNA NanoFect ADCM NanoFect DDS Active NanoFect siRNA
120. 2007 3 Debiopharm 27 ADA 269 29 28 27 26 http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4571 07 3 08 3 09 3 10 3 11 3 12 3 13 3 14 3 SR Research Report 2015 8 7 1 718 1 755 1 369 1 006 1 872 2 981 5 155 7 247 13 772 4 0 43 6 6 1 5 27 237 43 121 11 22 60 99 181 203 51 142 79 26 31 43 31 132 112 150 1 906 1 955 1 450 1 066 1 981 3 112 5 473 7 589 14 209 24 32 29 24 19 38 19 39 169 50 45 38 35 27 2 0 2 6 11 12 12 11 11 510 114 6 710 319 85 89 80 70 57 550 133 6 752 495 1 992 2 044 1 529 1 135 2 038 3 663 5 606 14 341 14 704 7 4 9 11 2 5 50 40 17 226 133 63 110 188 99 99 163 156 233 136 71 121 189 104 149 203 173 1 700 1 040 540 104 16 1 29
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122. I http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved VA 4571 SR Research Report 2015 8 7 NC 4016 I S 1 I d NC 6300 K 912 T I II E7974 ADCM
123. I IL b LAB MD NC 4016 1 MD Anderson NC 6300 I NK105 1 4272
124. NC 6004 Orient Europharma Co Ltd I I b ITTRHBR MD NC 4016 http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved VA 4571 SR Research Report 2015 8 7 1 MD
125. 33 600 397 952 6 300 CX 404 252 CE 411 216 8 916 2013 11 2018 10 2 300 2013 11 2018 10 NC 6004 NC 4016 a i sh ared KMesearch http www sharedresearch jp Copyright C Shared Researc
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127. d C 10 20nm Active NanoFect Active NanoFect 4 NanoFect ADCM siRNA Active NanoFect Active NanoFect gt Active NanoFect 30 gt gt
128. DNA RNA RNAF RNAi RNAi siRNA RNA RNAi PTGS e SIRNA RNA RNA RNA RNA RNA siRNA 1999 Science RNA mRNA 1 RNA mRNA RNA mRNA
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133. NC 6300 I NK105 1 4272 ADCM Antibody Drug Conjugated Micelle ADCM ADC Antibody Drug Conjugate ADCM
134. OEP I 2012 10 1 b IH MD a i sh ared Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 1 ua VA 4571 SR Research Report 2015 8 7 d NC 4016 1 2013 12 MD NC 6300
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139. 389 0 97 500 ADA 495 A 2015 5 2 2010 10 W 2012 7 2013 1
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141. 2014 3 2014 3 471 466 1 126 ADA 1 174 1 104 1 176 1 122 ADA 1 198 1 30 67 32 75 NC 6004 NC 6300 pH Orient Europharma Co Ltd NC 6004 NC 4016 ADCM siRNA
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143. 471 EX 1 955 ADA 1 126 iM 1 929 ADA 1 104 1 970 ADA 1 122 1 53 85 30 67 F3 2014 3 2014 3 NC 6004 Phase I Phase Ib II NC 4016 Phase I ADCM
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145. Active NanoFect siRNA 2016 3 137 2015 3 2015 3 19
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150. 3 2008 3 IPO http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved VA 4571 SR Research Report 2015 8 7 2008 2008 9 4 116 75 Cyntec Co Ltd 2010 6 4 819 100 2010 12 68 987 690 2011 1 3 18 500 601 2011 4 6 3 000 87 HAF 2011 10 11 000 290 2011 1 11 14 170 429 2012 11 12 000 690 2012 11 2013 3 64 252 1 891 2013 10 33 600 8 651 2013 11 1 625 418 J P Morgan Securities plc
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152. pH CD40 Calando Pharma Inc IT 101 Calando Cyclocert TM REIR Cda Calando PEG Calando tt siRNA Access Pharmaceuticals Inc NC 4016 DACH Prolindac 2010 II HPMA Supratek Pharma Inc
153. 1 120 17 2015 3 3 VU ERBSRRSTRHRS 2014 4 12 939 4 2015 1 3 20 2015 3 919 A a i sh ared Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 1 ua VA 4571 SR Research Report 2015 8 7 33 CEDEPIEECDWITEIBOA 33 2015 3 2016 3 2016 3 2016 3 2 666 2 617 2 7
154. 8 7 1 268 900 1 268 900 1 268 900 1 257 460 2013 10 11 2013 10 7 1 4063 2013 10H 7 33 600 5 600
155. 85 VA 4571 SR Research Report 2015 8 7 NC 4016 I II NC 6300 2011 9 2013 1 SIRNA siRNA
156. 943 2013 2000 16 Sanofi 2008 20 2010 2003 DDS 1990 DDS DDS DDS FOAR
157. Copyright C Shared Research Inc All Rights Reserved VA 4571 SR Research Report 2015 8 7 NC 6300 I NK105 1 4272 ADCM Antibody Drug Conjugated Micelle siRNA
158. F3 2008 3 2008 4 H TLO 2008 9 B Orient Europharma Co Ltd NC 6004 2008 12 NC 6004 I II 2008 12 H Debiopharm S A NC 4016 I 2009 5 TLO 2009 11 B 2009 12 H TLO 2010 8 a Shared esearch http Www sharedresearc
159. Research Report 2015 8 7 BRAR 333 432 ANA 366 484 398 Orient Europharma Co Ltd 242 NC 6004 I 1 035 237 EU3FdICER oJ Ihe as 2012 11 Orient Europharma Co Ltd NC 6004
160. Shared Research Inc All Rights Reserved VA 4571 SR Research Report 2015 8 7 2014 2 2014 2 12 2014 3 31 1 100 402 632 40 263 200 1 100 2013 12 2013 12 26 NC 6004 Orient Europharma Co Ltd UF OEP NC 6004 C
161. dc 12 AS S 12 di i m 10 8 WEE TES 1 TLO 23 10 ad i m E 10 NK105
162. 0 2013 9 2016 3 Shared esearch http Www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved VA 4571 SR Research Report 2015 8 7 2 aM
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164. 15 8 7 20 100nm NanoCap a E NK105 siRNA Ai e e Ej Medicel NC 6004 K NC 4016 NC 6300 A L MOM X e Active Targeting j 2015 5 http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved VA 4571 SR Research Report 2015 8 7 Nano Carrier 2015 5 21 AE d
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171. Permeation and Retention Effect a i sh ared esearch z http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved VA 4571 SR Research Report 2015 8 7 EPRA R Enhanced permeability and retention effect Y hAaizurmura et al Concer Rerzeorch 1986 T6 G3H7 m amp BCTiitJRILIdS2UBM o 1 NanoCap 2 Medicelle 3 NanoCoat 3 NanoCap
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