ナノキャリア（4571）
Contents
1.2. 100nm EPR Enhanced Permeation and Retention Effect
3. kd 1 z Shared esearch d http7 www sharedresearchjp Copyright C Shared Research Inc All Rights Reserved 43 89 v E gt Shared esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4571 SR Research Report 2014 6 10 NC 6004 NC 4016 NC 6004 ITI TEEGPR
4. 2 IL 2 IL 2 RO IL 2 T CTL 1
5. 2013 6 19 SIRNA 3 1mg kg siRNA
6. SR Inc SR Tnc Shared Research SR Inc
7. 3 000nm 300nm 100nm 100nm
8. 1 c Shared esearch d http7 www sharedresearchjp Copyright C Shared Research Inc All Rights Reserved 36 89 v E 4571 SR Research Report 2014 6 10 2014 3 3 2014 2 12 2014 3 3 2014 3 3 Orient Europharma Co Ltd 444 A 121 1
9. DDS DDS GMP Good Manufacturing Practice International Conference on Harmonization ICH
10. NanoCap NK105 1 4272 NK105 2002 6 a Shared esearch http Wwww sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 19 89 E gt Shared esearch
11. GCA SBS
12. DIC KLab TOKAL
13. kd 1 Shared esearch d http7 www sharedresearchjp Copyright C Shared Research Inc All Rights Reserved 83 89 v E gt Shared esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4571 SR Research Report 2014 6 10
14. siRNA 3 2013 5 13 Regulus Therapeutics Inc RNA kd a z Shared esearch d http7 www sharedresearchjp Copyright C Shared Research Inc All Rights Reserved 64 89 v E 4571 SR Research Report 2014 6 10
15. 1 1 2 kd a A z Shared esearch d http7 www shared
16. Bristol Myers Squibb SU EL Dach a P Shared esearch u http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 85 89 e E 4571 SR Research Report 2014 6 10
17. DDS 4571 SR Research Report 2014 6 10 N UVMWBR 0L AR 46 6 23k 393 4363 7941 amp F1 37 196 1 6 268 15 2011 2 Avastin Roche 4763 3 Herceptin Roche 4728 13 Taxotere Sanofi 1023 14 Suten
18. 2 2012 2 2012 2 28 2012 3 340 440 360 512 390 514 430 516 NC 4016 NC 6004 2012 1 2012 3
19. Anti body Drug Conjugate Micelles ADCM 2014 2 H 2014 2 12 2014 3 31 1 100 402 632 40 263 200 1 100 Shared esearch u http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 34 89 gt Shared esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4571 SR Research Report 2014 6 10 2014 1 2014 1 14
20. 2012 2 9 2012 3 3 2012 1 2012 1 26 kd a M z Shared esearch y http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 74 89 v E 4571 SR Research Report 2014 6 10 1 2 8 1 2012 3 21H 30 28 29 988 840 28 000
21. Dl DNA RNA nb 19 5
22. NC 6004 NC 6004 OEP I II 2013 6 NC 6004 I II TFDA Taiwan Food and Drug Administration
23. 12 000 24 000 2013 3 NK105 1 4272 2012 7 III NC 6004 Orient Europharma Co Ltd II TEES
24. siRNA siRNA AMD siRNA siRNA LU GE siRNA
25. NC 6004 NC 4016 2013 3 335 1 130 2013 3 2013 3 1 kd 1 z Shared esearch d http7 www sharedresearchjp Copyright C Shared Research Inc All Rights Reserved 66 89 v E gt Shared esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4571 SR Research Report 2014 6 10 2013 2 2013 2 18 NC 6004 2013 2 13
26. Abraxis Bioscience Inc DDS In Vitro A 84 89 4571 SR Research Report 2014 6 10 In Vivo 1976 Debiopharm Debiopharm 1994 Sanofi Aventis 1999 2004 Sanofi Aventis Eloxatin
27. MediCelle Debiopharm 2011 3 2005 3 Debiopharm S A NC 4016 2009 3 TO Debiopharm I 2011 3 Debiopharm I 2012 3
28. QOL Quality of Life NC 6004 2006 5 1
29. 10 ADCM 1 1 2014 5 ADCM 2014 5 ADCM
30. 2013 6 O0 4571 SR Research Report 4571 SR Research Report 2014 6 10 2012 7 2013 10 2013 9 2013 10 8 651 11
31. 2 MediCelle 3 NanoCoat 4571 SR Research Report 2014 6 10
32. NK105 Medius Associates 2001 0 5 I 5 10 II 8 1596 III 10 20
33. RNA ADCM ADCM Antibody Drug Conjugated Micelle ADCM siRNA
34. ADCM siRNA 211 224 16 gt Shared esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457
35. 1967 Bristol Myers Squibb I IL III IV I
36. 3 NanoFect 2013 5 2013 5 H 31 200980118842 4 63 89 4571 SR Re
37. q PEG REA 2
38. rapinis RM 21 ou a td 12 SE NK105 3 p m v iiic Sigur gue pim 10 Bak 8 m premisse mms TLO 23 X ELCHE NO 6004 ee MAN dE NIRE 2 iiia sca a daa 8
39. RNA microRNA microRNA 20 Alnylam Pharmaceuticals Isis Pharmaceuti
40. OEP 2 2014 3 2013 f 9 H 17 OEP OP Nano NC 6004 Orient Europharma Co Ltd OEP OEP OP Nano 1
41. 20 100 ABA 180nm 1800nm 4000nm 7300nm 8000nm T CEER Y 20 100nm 20 100 nm 14 89 4571 SR Research Report 2014 6 10
42. Shared esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved Q e E a L Shared csearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4571 SR Research Report 2014 6 10 EPR Enhanced permeability and retention effect Y Matsumura et al Cancer Research 1986 46 6387 amp rTit IILd455U7sBH o0 REAR 1 NanoCap 2 Medicelle 3 NanoCoatP 3 NanoCap z A74
43. 1996 6 CEO iPS COO Chief Operating Officer 2008 6 2007 12 2008 5 MG 1980 2005 7 CSO Chief Scientific Officer 22
44. MD II 2 2013 6 20 A 1 4063 P z Shared esearch d http7 www sharedresearchjp Copyright C Shared Research Inc All Rights Reserved 62 89 v E gt Shared esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4571 SR Research Report 2014 6 10
45. gt Shared esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved gt Shared esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4571 SR Research Report 2014 6 10 3 2013 6 NanoFect 3 A 3 120 140nm
46. NanoBiotix X NanoBiotix
47. 2007 3 2014 3 a L Shared csearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4571 SR Research Report 2014 6 10
48. II 1 II ILI kd 1 z Shared esearch d http7 www sharedresearchjp Copyright C Shared Research Inc All Rights Reserved 86 89 v E gt Shared esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved rd 4571 SR Research Report 2014 6 10 IV CES o 0 FDA
49. P E 1 7 700 700 J P Morgan Securities plc 6 300 840 5 460 JP P Morgan Securities plc J P
50. 2 760 NC 4016 II 912 PE1
51. Orient Europharma Co Ltd UF OEP NC 6004 OEP 2012 11 OEP OEP NC 6004 OEP tt OEP OEP 800
52. 2013 529476 NanoFect 1 B B 30 50nm siRNA ATP 2 2013 11 2013 11 22 NC 6004 NC 6004 2010 517837 2013 11
53. ADCM siRNA NC 6004 OEP 1 b H
54. NanoFect NanoFect 2014 5 19 gt Shared esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4571 SR Research Report 2014 6 10 201
55. OEP I 2012 10 E PI b I MD Anderson MT Shared esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved CN e E 4571 SR Research Report 2014 6 10 NC 4016 I 2013 12 MD Anderson
56. NC 4010 2004 5 NK105 I 2004 5 TLO 2005 3 H Debiopharm S A NC 4016 2006 5 NC 6004 1 2006 6 NC 4010 2006 7 TLO
57. 24 7 NC 6004 Orient Europharma Co Ltd OEP 2013 6 1 2013 6 3E P I b I 3 da C 3 NC 4016 2013 5 I
58. 2012 3 2012 3 1 4523 2012 7 Shared esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved e e E b 4571 SR Research Report 2014 6 10 2012 10 A NC 6004 1 3 2012 10 B Orient Europharma Co Ltd amp NC 6004 2013 5 NC 6300 K 912 2013 5 NC 4016 1 2013 6 NC 6004 ID II
59. AUC NK105 2010 8 1 2012 7 III II NK105 380 2 2015 F 2016 3 NDA New Drug Application NK105
60. QOL Shared Research d http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved ow gt Shared esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4571 SR Research Report 2014 6 10 DDS C 60 DDS Johnson amp Johnson Abraxis BioScience Nasdaq ABII
61. 1 4272 2012 7 NC 6004 Orient Europharma Co Ltd OEP 1 2012 10
62. 1 955 2014 3 1 123 1 929 ADA 1 094 1 970 1 113 10 89 gt Shared esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4571 SR Research Report 2014 6 10 NC 6004 NC 4016
63. OEP OEP OEP OEP 2013 9 OP Nano OP Nano 29 5 2016 12 2012 8 31 TFDA Taiwan Food and Drug Administration IDB Industrial Development Bureau Ministry of Economic Affairs gt Shared esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4571 SR Research Report 2014 6 10
64. 2015 3 OEP 330 AAA 30 1 U OEP 2014 3 926 2015 3 1 599 NC 6004 NC 4016 siRNA ADCM 690 2 285
65. DNA NC 6300 pH pH NC 6300 Improved anti tumor activity of stabilized anthracycline polymeric micelle formulation NC 630 M Harada I Bobe H Saito N Shibata R Tanaka T Hayashi Y Kato Cancer Scie
66. http www sharedresearch jp Email info sharedresearch jp 3 31 12 03 5834 8787 a A Shared esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 89 89
67. 2011 3 2012 3 2011 3 1 391 P 45 89 4571 SR Research Report 2014 6 10 07 3 08 3 09 3 10 3 11 3 12 3 13 3 14 3 103 263 354 118 84 346 374 472 4 1 154 0 34 6 66 7 28 4 310 7 7 9 26 3 92 68 247 71 51 125 273 182 12 194 106 47 33 221 101 290 11 396 74 096 30 196 39 896 39 496 63 996 27 096 61 496 729 647 638 540 553 555 628 1 413 704 8 246 296 180 496 458 096 655 996 160 296 167 996 299 296 717 453 532 493 520 334 527 1123 3 7 9 4 1 2 106 244 13 46 1 4 31 35 12 215 727 492 524 492 550 366 432 1095
68. CEO 1996 6 1997 8 1 4403 2001 1 TLO 2002 6 1 4272 A 50 89 gt Shared esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4571 SR Research Report 2014 6 10 2002 11 A
69. Supratek Pharma DDS SP1049C 2005 II gt Shared esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4571 SR Research Report 2014 6 10
70. CFO Chief Financial Officer 2011 6 1976 1999 4 MG CFO 2003 9 2008 1 Shared esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved Q e E gt Shared esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved rd 4571 SR Research Report 2014 6 10
71. 2013 9 30 364 352 33 600 P 58 89 4571 SR Research Report 2014 6 10 397 952 6 300 G3 404 252 JP J PMorgan L Securities plc uu 11 216 8 916 2013 11 2018 10 2 300 2013 11
72. 2014 3 1 2013 8 9 2014 3 1 kd a A z Shared esearch d http7 www sharedresearchjp Copyright C Shared Research Inc All Rights Reserved 39 89 v E 4571 SR Research Report 2014 6 10 150 2013 3 1 10 277 179 190 ADA 179 191 ADA 180 NK105
73. Genentech Roche
74. NC 6004 2 760 x 2012 4 2016 3 NC 4016 912 2012 4 2016 3 NC 6004 NC 4016 NC 6004
75. OEP IND NC 4016 MD 1 NC 6300 K 912 I e Shared 4571 SR Research Report 2014 6 10 SR NC 6004 NC 4016 NC 6004 El
76. 2012 3 2 4 1 2011 9 290 2011 3 2011 5 12 2011 3 NK105 1 4272 II III 2011 2 21 TII
77. 1 268 900 1 268 900 1 268 900 1 257 460 2013 10 11 2013 10 7 1 4063 2013 10 7 33 600
78. A 34 89 4571 SR Research Report 2014 6 10 PEG
79. A 60 89 gt Shared esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4571 SR Research Report 2014 6 10 OP Nano OP Nano gt NT 1 000 2016 12 8 900m Huwei Yunlin OP Nano 2015 3 NC 6004 2013 6 2013 9 10 2014 3 2014 3
80. kd a A z Shared esearch d http7 www sharedresearchjp Copyright C Shared Research Inc All Rights Reserved 81 89 v E 4571 SR Research Report 2014 6 10 m DACHPt
81. 100 AAM 233 130 472 26 3 688 926 1 123 2013 527 225 211 1 095 432 1 114 484 http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved gt Shared esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 2014 6 10 NK105
82. http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 2014 6 10 T E gt Shared esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved rd 4571 SR Research Report 2014 6 10 DNA DNA pH pH7 pH pH7 pH7 pH7 35 pH RNA DNA DNA 2
83. NK105 SR 30 14 2 2 5 28 SR NC 6004 NC 6004 NC 6004 19 800 4 20 89 4571 SR Research Report 2014 6 10
84. SR Inc SR Inc SR Inc SR Inc SR Tnc SR Inc
85. 2012 7 2 DDS 2012 6 2012 6 H 27 NC 6004 IND NC 6004 IND Investigational New Drug 6 27 IND 1 Shared esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved Q e E b 4571 SR Research Report 2014 6 10 TII IIb III 2012 6 5 N
86. VII VII VII LFB P 67 89 gt Shared esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4571 SR Research Report 2014 6 10 2370 2009 10
87. 0 0 2 0 0 0 0 0 5 0 0 0 0 550 31 0 50 4 16 2 728 492 522 492 553 396 482 1 111 2 2 2 2 2 2 2 2 729 494 524 495 555 398 484 1114 SR 2007 3 Debiopharm 27 269 29 ADA 28 27 26 2008 3 ARI Debiopharm 148 56 NK105 101 3896 2009 3 Debiopharm 229 659 Orient Europharma 119 33 6906 2010 3 2010 3 26 2010 3
88. 2013 10 esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4571 SR Research Report 2014 6 10 9 069 2013 11 2018 10 2014 5 NC 6004 2019 3 800 1 100 8 fs Shared esearch http www sharedresearch jp Copyright C Shared Researc
89. Novosom pH CD40 Calando Pharma IT 101 Calando Cyclocert TM Calando PEG Calando siRNA Access Pharmaceuticals tnc NC 4016 DACH Prolindac 2010 II HPMA
90. 2 3 gt Shared esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4571 SR Research Report 2014 6 10 2011 10 1 W 2010 10 1 2012 7
91. 2011 4 3 220 31 1 M 76 89 4571 SR Research Report 2014 6 10 15 59 11 596 2006 9 2 700 37 09 29 6 tt 18 596 2012 1 11
92. B 30 50nm siRNA ATP ATP Adenosine Triphosphate 3 Ci 10 20nm 2011 8 RNAi 2013 5 Regulus Therapeutics Inc microRNA RNA
93. NC 4016 II NC 6004 IND Phase II Phase lIb III Phase IIb III Phase pom 2 pom 2 lib Phase Ilb Phase III IND Phase Eu 2008 3 m 2014 3 NC 6004 NC 4016 siRNA ADCM 2013 3 238 2014 3 926 2015 3 1 599
94. 418 9 069 24 270 727 S Ce gt Shared esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved rd ON Shared csearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4571 SR Research Report 2014 6 10 2015 3 15 3 14 3 15 3 pel ERA 326 146 472 330 228 096 46 6 26 3 30 1 102 80 182 223 67 290 1976 9 26 0 187 2 68 596 45 596 61 496 724 689 1 413 222 496 470 196 299 2 501 622 1 123 1 955 436 659 1 095 1 929 437 676 1 114 1 970 SR
95. 2007 2 TLO pH 2007 10 Debiopharm S A NC 4016 2007 11 NK105 II S 2008 3 2008 4 TLO 2008 9 Orient Europharma Co Ltd NC 6004 4571 SR Research Report 2014 6 10 2008 12 NC 6004 1 II 2008 12 Debiopharm S A NC 4016 I 2009 5
96. ADC 2015 3 1 599 2014 6 3 amp S Ce 4571 SR Research Report 2014 6 10 13 3 14 3 14 3 EM 1Q plo 3Q 4Q Fo 2Q 3Q EC 10 90 102 173 150 176 119 28 100 3 47
97. NanoCap e NK105 siRNA o o Medicell NC 6004 amp NC 4016 NC 6300 T 25 NanoCoat 2A T 4s AA NL AX e Active Targeting e 2014 3 31 Shared esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4571 SR Research Report 2014 6 10
98. 2013 10 2013 10 2014 3 37 2014 3 130 2013 9 kd 1
99. 3 2014 5 NC 6004 NC 4016 2 3 3 1 2 s 29 89 4571 SR Research Report 2014 6 10
100. 1 4502 2012 4 siRNA 2013 3 36 41 2 78 89 4571 SR Research Report 10 Must 7 37 PE1 6 58 5 56 m 3 44 3 38 2 67 Cyntec Co Ltd OEP 2 53 2 29 MSIP CLIENT SECURITIES 1 20 0 94 SR 2013 3 2014 3
101. 2010 3 Debiopharm 55 BAA 479 14 1196 28 2 A http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 46 89 4571 SR Research Report 2014 6 10 AJM 07 3 08 3 09 3 10 3 11 3 12 3 13 3 14 3 1 718 1 755 1 369 1 006 1 872 2 981 5 155 7 247 4 0 43 6 6 1 5 27 43 121 11 22 60 99 181 203 142 79 26 31 43 31 132 112 1 906 1 955 1 450 1 066 1 981 3 112 5 473 7 589 24 32 29 24 19 38 19 39 50 45 38 35 27 2 0 2 11 12 12 11 11 510 114 6 710 85 89 80 70 57 550 133 6 752 1 992 2 044 1 529 1 135 2 038 3 663 5 606 14 341 7 4 9 11 2 5 50 40 x 226 133 63 110 188 99 99 163 233 136 71 121 189 104 149
102. OEP 1 2013 6 PI b I NC 4016 2013 5 1 MD Anderson NC 6300 2013 5 1 9 ADCM Antibody Drug Conjugated Micelle siRNA
103. IL 2 2 IL 2 CTL IL 2 IL 2 2012 10 2012 10 26 1 4063 1 57 473 A 2012 4 26 H 2012 10 25 13 599 12 000 4571 SR Research Report 2014 6 10 689 676 FA 2012 11 15
104. 2007 2013 2016 1978 FDA DNA
105. 2014 6 3 siRNA NanoFect SIRNA NanoFect 3 A
106. 785 361 633 ADA 355 633 356 NK105 1 4272 2012 7 TIT 2 2014 3 3 2014 1 31 NK105 2015 e b c NC 6004 e Orient Europharma Co Ltd Hi A 2014 1
107. RNA RNA 2013 5 9 NC 6300 K 912 pH NC 6300 K 912 2013 5 7 NC 6300 K 912 IND 1 NC 6300 K 912
108. 2013 2012 10 1 2013 NC 4016 I a A Shared esearch u http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 41 89 e E 4571 SR Research Report 2014 6 10 MD The University of Texas MD Anderson Cancer Cente NC 6300 2013 5 1 IND
109. 2012 5 2012 5 10 2012 4 2012 4 H 26 DDS 2012 4 17 Shared esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved Q e E 4571 SR Research Report 2014 6 10 2012 4 4 2012 3 2012 3 H 29
110. 71 436 kd 1 z Shared esearch d http7 www sharedresearchjp Copyright C Shared Research Inc All Rights Reserved 38 89 v E 4571 SR Research Report 2014 6 10 267 437 268 A NK105 1 4272 2012 7 III NC 6004 OEP 2013 6
111. PMDA 1 4523 2012 3 2012 5 10 2012 3 346 ADA 310 79 334 2011 3 520 366 2011 3 550 398 2011 3 555
112. II NC 6300 2011 9 2013 1 siRNA SIRNA
113. RNA mRNA 1 RNA mRNA RNA mRNA RNA RNA RNAi RNA 20 RNA tRNA RNA rRNA U 4571 SR Research Report 2014 6 10 RNA 300 20 10 300 DNA RNA
114. 5 089 2012 10 26 236 395 9 229 2012 10 9
115. FDA 2006 0 IND Investigational New Drug PFS Progression Free Survival 87 89 T E gt Shared esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved w 4571 SR Research Report 2014 6 10 277 0882 5 4 19 047 169 6550
116. NK105 1 4272 2012 TIT NC 6004 Orient Europharma Co Ltd 1 II 2011 7 II P z Shared esearch y http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 42 89 v E 4571 SR Research Report 2014 6 10 NC 4016 1
117. TLO 2009 11 2009 12 A TLO 2010 8 NK105 I 2010 10 B LFB Biotechnologies rhFVIIa VII 2011 3 Debiopharm S A LICENSE AND SUPPLY AGREEMENT Termination Agreement 2011 7 LFB 2011 7 NC 6004 II 2011 8 2011 9 NC 6300
118. 2006 3 2013 3 2012 3 2014 3 2007 3 2008 3 3 IPO 2011 3 2012 3 2013 3 2014 3 9 069
119. 1 2 8 29 988 30 702 67 000 127 690 2012 1 25 234 885 54 4 Shared esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved Q gt Shared esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4571 SR Research Report 2014 6 10 25 432 2012 3 19
120. 2011 9 NC 6300 2012 3 1 4523 2012 3 1 700 2 025
121. 5 600 28 000 2013 10 21 2013 10 23 0 90 1 00 Shared esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved e Shared esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4571 SR Research Report 2014 6 10 P J P Morgan Securities plc 2013 10 28 2013 10 30 8 400
122. 416 297 1 174 1 238 AAM 1 176 1 240 1 198 1 262 1 NC 6004 Orient Europharma Co Ltd I L Orient Europharma 2 10 A 61 89 4571 SR Research Report 2014
123. 2013 6 B Orient Europharma Co Ltd NC 6004 RAN 2013 10 amp 2014 3 2014 3 18 Antibody Drug Conjugated Micelles K Antibody Drug Conjugated Micelles ADCM 2014 3 3 201 4 3 3 gt Shared esearch http www sharedresearch j
124. 2010 9 Xt 2009 5 25 TIO siRNA siRNA PR FO OPTS LE EEE STC MEDEA GAR NanoFect 2013 6 siRNA siRNA
125. 2013 9 i 2014 3 416 466 E175 2014 3 2 2013 11 11 2014 3 2 2014 3 2 Orient Europharma Co Ltd OEP 326 228 0 501 267
126. PE1 780 A 60 2 2012 3 21H 20 43 30 702 860 28 000 PE1 800 El 60 8 2012 3 21H 15 67 67 000 2 025 15 2 010 30 000 PE1 62 fil 5
127. DDS 2012 10 5 NC 6004 T NC 6004 IND Investigational New Drug 2012 6 27 NC 6004 I NC 6004 10 kd 1 z Shared esearch d http7 www sharedresearchjp Copyright C Shared Research Inc All Rights Reserved 69 89 v E 4571 SR Research Report 2014 6 10 2 NC 6004 II III IIb III
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130. ID TLO 24 A 6 NC 4016 2 ENT dd 3 II 8 so prm 1 TLO m F 8 me K 11 mor nm
131. 20 a Tad gt Shared esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 30 89 Shared esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4571 SR Research Report 2014 6 10 SW Strengths Weaknesses 30 2014 5
132. cer I III IIb III 2012 10 1 NC 6004 2013 3 NC 6004 Orient Europharma Co Ltd 1 2 Orient Europharma 1 2 3
133. GE b IT MD Anderson NC 4016 I 2013 12 MD Anderson NC 6300 I 2013 9 ADCM Antibody Drug Conjugated Micelle SIRNA NanoFectS
134. 03 3548 0213 1996 6 14 H 2008 3 5 HP http www nanocarrier co jp 3H TIR IR IR info nanocarrier co jp http www nanocarrier co jp ir index html IR 03 3548 0217 rad 88 89 4571 SR Research Report 2014 6 10 SR
135. Debiopharm NC 4016 48 28 8mg m I 1 2013 12 MD Anderson 2024 2025 3 NC 4016 IL MT Shared esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved e e E 4571 SR Research Report 2014 6 10 SR NC 6300 DNA
136. 1 TLO TLO 7 oe ey 10 l FERERKES 71 2 RURO HIER E uid i RADI E CES ETE RM SN EE 2S RMccKES x PM 7
137. NC 6004 2013 2 7 NC 6004 2013 1 2013 1 16 NC 4016 2012 11 2012 11 9 LFB Biotechnologies LFB Biotechnologies LFB 2010 10 LFB VII VII
138. NC 6004 NC 6004 NC 6004 1 09705599 0 2013 12 2013 12 26 NC 6004 Orient Europharma Co Ltd OEP NC 6004 OEP 2014 1 IND
139. 1 II Hydration Hydration NC 6004 NC 6004 ED 7 NC 6004
140. ER UAM REE 4 2 3 pH aa aaa pH E 17 MA 5 2 AME TES iD lt 6 ME dare cm ME pied SR a Shared esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4571 SR Research Report 2014 6 10 2015 PI NK105 pure 2012 7 NDA gt dd BRA lp iini 2018 E
141. 2013 5 NC 6300 K 912 IND xl 2013 9 1 2024 2025 3 a A Shared esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 24 89 e E 4571 SR Research Report 2014 6 10 siRNA ADCM Antibody Drug Conjugated Micelle siRNA siRNA small interfering RNA RNA mRNA RNA RNA
142. 2015 1 2010 2011 II NC 6004 Orient Europharma Co Ltd I TI MTD NC 6004 NC 4016 Debiopharm 2011 3
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144. 2013 3 371 370 A488 812 AAM 406 828 AAM 461 ADA 831 NC 4016 NC 6004 I II 2013 3 335 85 35 15 2014 3 297 1 238 1 240 1 262 ADA 2013 3
145. DDS 2005 AstraZeneca 2009 3 f amp 1 500 2008 3 3 600 NK105 SR DDS AstraZeneca Teva EGFR JE Roche Genentech tt Roche HER2 neu
146. NC 6300 2013 5 I 9 ADCM Antibody Drug Conjugated Micelle SIRNA 2012 7 2013 10
147. RNA 1 RNA mRNA RNA DNA RNA RNA RNAi RNAi siRNA RNA RNAi PTGS e SIRNA RNA RNA RNA RNA RNA siRNA 1999 Science
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150. 840 1 P Morgan Securities plc J P 5 460 pem 6 300 JP P Morgan Securities plc 2013 11 22 e 2013 11 25
151. Shared search SR Research Report 2014 6 10 4571 sr_inquiries Gsharedresearch jp 4571 SR Research Report 2014 6 10 TEDE E nro e ET 4 4 7 usq PME TERENTUM 14 rr dr
152. 2012 7 2012 7 30 2013 3 89 69 509 529 510 530 511 531 267 242 1 147 1 172 1 164 1 189 1 167 1 192 2012 7 17 1 NK105 1 4272 ITI 2012 7 H 10 pH
153. OEP 2014 2 2014 5 NC 6004 300 3 2018 F 2019 3 OEP FI IND 2012 10 T gt Shared esearch http www sharedresearch jp Copyright C Shared Research Inc All R
154. Phase 2013 12 17 e gt Shared esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4571 SR Research Report 2014 6 10 2013 12 5 Hl Atid E v UTCAI S SEX EIPN CSUCRISEEDE SED TE
155. NT 29 500 000 NC 6004 OEP 2012 11 OP Nano OEP NC 6004 NC 6004 OP Nano OP Nano GMP Good Manufacturing Practice
156. http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved rd 4571 SR Research Report 2014 6 10 1 2004 5 2006 4 Drug Delivery System 24 1 2009 NK105 AUC 15 NK105 150mg sq m 210mg sq m 4 1 2007 11 II II NK105
157. 2013 3 2013 2 99 89 267 509 267 510 268 511 2013 2 370 267 812 1 147 828 1 164 831 1 167 kd 1 Shared esearch u http7 www sharedresearchjp Copyright C Shared Research Inc All Rights Reserved 70 89 v E 4571 SR Research Report 2014 6 10 2012 9 2012 9 21 NC 6004 Phase 1 II Phase I stage Orient Europharma NC 6004 Phase I stage 71 Dr Wu Chou Su National Ch
158. 2018 10 NC 6004 NC 4016 siRNA ADCM Antibody Drug Conjugated Micelle 2013 9 2013 f 9 30 2012 7 c 2013 9
159. H 14 32 36 BR 37 icra E E E 46 AEIR oire unran nira eN E AIOE ENKEN ATUA A TEREE RASTE TANKET SNES 47 Peyo EA e EE 49 EP E E EE 50 Aee E 50 ZIERA REVA e E E A E E 53 lige E E E E 77 NE E E E C 78 vx cl S 79 Dnt rnaMudr zi 79 a Mr MT c E EE N E 80 llo MAE 80 j 7 MmMMMMM 88 d Shared esearch u http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4571 SR Research Report 2014 6 10 10 3 11 3 12 3 13 3 14 3 118 84 346 374 472 330 66 7 28 4 310 7 7 9 26 3 30 1 47 33 221 101 290 55 996 29 296 566 4906 54 496 187 296 39 896 39 496 63 996 27 096 61 496 493 520 334 527 1 123 1 955 8 gt a 492 550 366 432 1 095 1 929 495 555 398 484 1 114 1 970 aiias EET 12 858 22 089 23 494 32 531 40 265 EPS 38 7 36 0 17 4 18 9 30 4 DPS 0 0 0 0
160. MD Anderson NC 6300 2013 5 I 2013 3 2013 5 13 2013 3 Orient Europharma Co Ltd 373 ADA 7 99 526 2012 3 333 ADMA 432 ADA 366 484 398 kd a A z Shared esearch d http7 www sharedresearchjp Copyright C Shared Research Inc All Rights Reserved 40 89 v E 4571 SR Research Report 2014 6 10 Orient Europharma C
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162. v 44 89 Shared esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved rd 4571 SR Research Report 2014 6 10 Debiopharm 2011 5 12 17 LFB Biotechnologies tt LFB rhFVIIa recombinant human factor VIIla VII NC 4026 2011 3 KEK LFB 2011 20
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170. 6 10 2013 6 2013 6 25 NC 6004 NC 6004 Orient Europharma Co Ltd OEP NC 6004 1 II OE P 6 24 TFDA Taiwan Food and Drug Administration 2013 6 24 NC 6004 IND NC 6004 6 21 FDA Food and Drug Administration
171. All Rights Reserved 4571 SR Research Report 2014 6 10 07 3 08 3 09 3 10 3 11 3 12 3 13 3 14 3 z pai CF A 663 588 457 452 578 293 635 1 098 CF B 62 19 4 8 5 1 721 121 7 059 FCF A B 725 607 461 460 582 2 015 757 8 158 CF 1 143 643 75 97 1 449 1 924 2 327 9 581 A 8 15 16 16 16 18 7 5 B 11 14 3 2 4 19 20 27 C 6 78 71 29 48 30 41 54 FCF A B C 727 571 440 452 590 429 538 1 189 SR 2014 3 BARAT
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175. cals 26 89 4571 SR Research Report 2014 6 10 C microRNA E microRNA siRNA 1 RNA 2025 1 RNA 2 siRNA mRNA RNA 500 RNA 3 1 RNA microRNA
176. eng Kung University Hospital Taiwan Phasel GEM NC 6004 MTD Maximum tolerated dose RD Recommended dose 19 NC 6004 3 1 30 60 90 120 mg mi GEM 3 2 1000 mg m 1 8 HE Dr Wu Chou Su Phase I stage NC 6004 MTD 120 mg ni RD 90 mg m G Pt
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183. search Report 2014 6 10 2008 525801 2013 5 30 A NC 4016 IND NC 4016 I 5 29 FDA Food and Drug Administration 1 MD Phase I Unit II 1 2013 5 H 20 1 4403
184. t Pfizer 950 15 Zoladex AstraZeneca 943 2013 2000 16 Sanofi Aventis 2008 20 2010 2003 DDS 1990 DDS DDS DDS
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