NO.326 2012年2月
Contents
1. 1 2 3 4 1 22. 30 50 25C 25 30 DIC
3. NN 1 8mg 1 2
4. 36C 35C 37 2 2 2011 3 11
5. 30C 3S26 7 1 2 1 2 3 1 3
6. 1 2 3 4 5
7. AUC CYP1A2 CYP2C9 CYP2C19 CYP3A4 DN A 16mg 32 mg 1 864 194 10 4 8mg 3 4 1 0 0 5 0 5 RR RI
8. 2 1 2 2 m 3
9. MA ff gt LL 3 Drug Safety Update No 206 2012 1 Ay 22 2 2 A A A A A A A 2 A A A A 2 A A 22 22 A A A A A A A gt A A A Yaws aw ws X CT S26 2 1 1 x 1 0Q 1 0Q co er 150mg 150mg 161 2 RH IN IN lt lt W 20mg
10. 32 34C PCPS 326 8
11. 1 115 408 36 6 4 7 52 3 1 35 2 2 24 2 1 23 1 0 3 S26 3 2 3 a 0 2 0 1 0 1 150mg 1 2
12. 1 1 S26 1 2 2 gt 38 3 23 12 PMDA
13. PMDA PMDA PMDA http Www info pmda go jp iyaku_info oshirase_index html 2 1 23 5
14. G100 i pF a 2 5mg 20mg EET i 1 5mg 1 1 20mg 1 2 EE OA I 2 30mL min 1 1 10mng 3
15. 3 150mg 1 1 300mg 1 RA 2 1 Cmax 5
16. 1 2 1 3 1 S26 4 8mg 1 2 A a
17. EE Oa NNN 2 33 30C 2 1 2 3 i
18. 3 4 5 1 4 gt 35 NE A SA se 922 6 6 30C lt 30C
19. Drug Information News NO 3 26 2012 2 EE Z TEL 0834 31 7716 lt FEAX 0834 32 5349 A e mail yaku tokuyamaishikai com AS X http www tokuyamaishikai com yaku index htm A A 1 A A A A A A A A A A S 15mg L 0 2mg 6 2 1 RO SE 8 O A A A A A A A A A A A A A A A A A A A A A A A
20. 2 Fv A A A A A A A A A A A A A A _ Ao 14 CV 3 1 15mg 15 30mg 1 1 S26 5 DB A 2 2 A A A 2 A A A 1
21. A A A A A N 2 No 286 2011 12 A EE HP A A EE EHP 2 A A A EE A A GE A 2 A Em 2 A 2m Em mm mm am 1 2mg 5mg 25mg 100mg 1 A A A 0 2
22. 8 AUC 6 5 1 P Pgp 2 Cmax 2 5 AUC 5 2 P Pgp 869 225 25 9 139 16 0 113 13 0 11 1 3 11 1 3 9 1 0 ALT GPT 21 2 4 y GTP 14 1 6 12 1 4
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