2004年 全文 - 協和発酵キリン
Contents
1.2.
3.
4.
5. LCA
6. 1 RC P11 McE
7. ar II 30 3
8. 2004 7 4
9. gt 3S H 3 2003
10. 3 1 lt
11. P12 25 46 2003 12 12 48
12. EEIOINIIE 2
13. 1 500 1 D
14. 03 3282 0075 El LM Wl ll MM LE 1 T ss TIE HILT TI Jr N Ut ll FF 2004 4
15. 1996 1
16. 1
17. 2003 6 100 2004 4 1 1999 2002 2001 2002
18. 9 HH RC
19. 2003 12 12
20. 1
21. F _ 3 57 Biokyowa Inc Agroferm Hungarian Japanese Ferme
22. MR MR MR MR SMART 2002 10
23. lt gt EBM Evidence based Medicine 13 100 300 1 g 40 000
24. 1 SOx 2 NOx 3 COD Chemical Oxygen Demand COD
25. 2 2 4 a 2 x e 2003 12 9 9 2004 1996 97 2 e PRTR 2 1 13
26. 2002 2002 10 2003
27. 7 1999 3 21 32 1999 3 2004 4 7
28. GMP ISO HACCP IS09001 GMP
29. CDP 2003 10 20
30. 5 3 GPMSP Good Post Marketing Surveillance Practice PWR
31. Q amp A
32. P16 P26 P35 2003
33. P43 2C
34. 2003 399 19 CO2 15 BOD 17 000 xel 416 CO gt SOx 101 13 NOx 45 5 261 100 626 17 000 ke 3 SSI
35. _ U VM HH 2007 e 2003 158 1 408 708 250 e
36. 5 2003 11 15 2 S3
37. e ISO14001 3 2 5 5 000 3 000 3
38. 3 0
39. GMP ISO9001 HACCP 22 SMART 2003 8 3 4 5 3 24 mm
40. 2 _ _ 2 _ 15 18
41. 1991 NGO CERES 2 PDCA CSR
42. 1998 2001 2004
43. gt e 2003 3 3 5 3 7 e 2003 CO2 684 3 3 1990 97 2 e 2003 302 6 6 e 752
44. 1970 2001 i
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46. pH 004 4 2003 COD COD
47. 11 1 0436 23 9111 220 000m2 lt 2000 11 27 2 3 0593 31 0624 320 000m2 lt 2000 7 23 600 1 055 988 6000 24 000m2
48. 2 2 8 12 1 5
49. Or IE DP 2003 2 126 2005 4 2004 4
50. 50 2004 3 8 2 JICA ASEAN 2003 10 2004 3 2004 9
51. EE 2
52. CONO 3 7 7 MP300
53. COPE Trial EBM Combination Therapy of Hypertension to Prevent Cardiovascular Events Trial 2 1 COPE Trial 3 I I
54. 1 2 GC por 1E MCSRU 1999 3
55. 2 3 Ei Fi i UN a i es E 10 4 1 1999 s 0 i994 4 2004 6 TRIE oo re 2004 4BRH e
56. 2 mm ISO9001 4 GMP S HACCP 9 P8 P34 P8 P32 P48 P8 P22 P25 P27 1 4 1S09001 2 MSDS 5 GMP Good Manufacturing Practice 6 HACCP Hazard Analysis and Critical Control Point
57. 3
58. 228o MR i FAX E Mail di kyowa co jp 0120 850 150 FAX 03 3282 0102 Q amp A URL http iyaku kyowa cO jD co a A Pe
59. lt 3 ISO14001 4 OSHMS Occupational Safety and Health Management System LO 5 VSC PAN VA 7
60. LIME 5 10 000 SO 0 5
61. 3
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66. CS li sr TE 7 9 2 1 2 10
67. 9 9 62 4 62 2 61 8 e0 4 61 7 60 0 90 95 96 97 98 99 00 01 02 03 1 2002 pg 9 90 95 96 97 98 99 00 01 02 03 2010 1990 909
68. 100 100 100 a lt 4 NYUI HI4 CO gt 2 130 16 000 e CO 43 a a 53 000 ke 640 TN TP 470 20 150 40 630 CO gt SOx 670 1 070 NOx 610 25 In 1
69. i A Ma a IES Pc 6 005 J
70. 780 750 704 760 764 1 119 2004 3 2003 G3 686 61 2010 113 118 124 102 166 3 2003
71. BOD 2004 Degussa AG 3 000e 9 96 9 98 99 00 01 02 03 PS i
72. 2002 12 7 3 4 PCB PCB 2 2001 6 PCB
73. gt Tel 03 3282 0980 6 21 21 2004 9 30 100 8051 1 1 1 ua 21 Tel 03 3212 2272 2003 4 534 3 286 1 248 3 10 1 10 10 NASA NIH
74. GP ISO 2001 2003 79 83 ISO14001 43 70 99 86 mk 62 99 70 81 69 87 118 114 KEP 2010 CO2 gt 1990 s 1 2007 10 3 1 CO2
75. 2002 9 3 488 2 9 268 66 8 2004 3 31 105 69 1 2 1 3 2002 9 3 749 99 00 3 756 00 01 3 786 01 02 3 992 02 03 3 488 03 16 2 AN YaYeYo 40 6 1 798 668 674 SMU 374 910 9000NDM 2
76. 15 http www yasuienv net
77. 2003 1009 88 2003 2003 18 2004 7 1 http www kyowa co jp kankyoj er2003j1 pdf
78. 2 gt 2 3 GLP 3 5 T 1 37 EE GPMSP 3 1 2000
79. 3 COD N P 4 SOx NOx 0 2 3 7 0 6 LIME 100 5 ILIME 6 100 100 LIME
80. e 2003 3 0 15 0 002 e 2003 0 31 0 013 e e 2 126 e e OSHMS
81. 1 TOEIC 2004 4
82. http www integrex jp 50 1 2 P34 PDCA
83. 1 2 208 0 4 _ 369 _ _ _ 359 _
84. 310 NNOVATOR LL er 4 4
85. _ 2002 _ _ _ _ Th _ 1 _ _ _ _ _ _ _ _ _ QSA _
86. e SOx 13 NOx 2 8 149 SOx e COD 39 16 11 SOx NOx 1 500 1 000 60 gt GBS 1 299 1293 1229 _1200 177 0 so 2 8 1 072 8 900 600 as 609 SOx NOx_ 7 eoo 40o lt 300 200 99 00 01 02 03 99 00 01 02 03 2 COD 99 00 01 02 03 COD COD
87. MSDS 2 3 MSDS MSDS MSDS ISO14001 OSHMS
88. IEE3K k wlP4 2 gt i 5 PE e 360
89. COPE Trial 3 TH 8 1 000 3 000 2003 4 2004 10 2009 COPE Trial
90. 10 10 X 10 1100 1 8 0 53 0 93 0 61 230 340 58 140 1 4 0 17 0 23 0 24 9 2 9 7 y 2 4 0 019 0 001 0 038 0 004 125 3 12 Xx 26 Xx 2 760 Xx 5 9 x 100 Xx 59 XxX 8 2 6 6 18 0 24 1 0 1 4 3 6 00 4 900 CO2 620 140 320 0 017 14 0 0 22 0 0 009 O 0 30 0 3 0 03 27 9 0 27 0 0 30 O 0 54 O 4 0 04 3 7 O Dr 071 O 0 81 O 1 2 0 02 0 7 LIME
91. 6 1996 1 P7 6 96 2002 2004 2003 ISO14001 1 3 0 11 2004 ISO14001 SO14001 3 2003 OSHMS
92. LO 3 7LCIA 4 LCA Life Cycle Assessment i Pr CUNY lt SN i RC CSR e e 2
93. 3 S25 E KYOWA BIO INNOVATOR 21
94. 1 2003 6 2 8 CO2
95. gt P18 P19 DAAM gt P19 gt P32 P42 2 P41 Kyowa Hakko Group s Sustainabilit Universe EE _ 3 i
96. MSDS MSDS 4 1 12 22
97. ADCC POTEL LIGENTW ME Fc i Ch ll ADCC NK 1 A
98. 12 1 2 1 3 12 12 2004 1996 97 2003 12 9 9 1996 97 6 2004 2 1 12
99. i UT 2003 12 11 599 53 7 48 20 85 100 TS oo R J gt gt NS a 7 C H Q a i 4 M P T 2003 FT http Www smrijp 203
100. PL 1995 7 2004 4 1999 10 2004 4 1999 5 2004 4 _ 1997 10 2004 4 9ox Ate 2004 22T es e 1998 9 2004 4 Im T 1995 5 2002 4 _ Ea Lr ri De 1986 4 2002 3 _ 1975 5 2004 6
101. 03 3282 0090 ee e HCFC 2010 HCFC HFC 5 000 2005 12 000
102. o 3 fifi il 2 SI 2 Be NR 0 POTELLIGENTTW MY
103. SMART MR 2001 6 2001 5 127 2002 10 080 2003 16 827
104. 35 585 23 561 1 1 453 0 1 291 0 15 0 13 0 1 0 1 1 218 a 312 6 331 2003 2002 2003 9 488 8 652 31 608 29 316 492 447 1 270 1 511 1 2 e
105. 1 U Ct EE Saccharomyces cerevisiae Pe 100 8185 1 6 1 2004 7 2005 7 Pear Yanni TEL 03 3282 0051 FAX 03 3282 0030 e mail info
106. 0 a 1 TTY
107. Act Check 1996 4 EtEEaK g32 gW4
108. MM 7 55 2004 3 1949 7 1 MR 26 745 99 2004 3 31 00 01 a 100 8185 1 6 1 TEL 03 3282 0007 99 7 866 00 7 766 01 7 299 02 6 749 03 _ 2002 9
109. 18 85 ll KEP 1 P34 CO2 2010 CO2 1990 2004 1998 0 2007 250 2004 1996 97 SOx 2 595 3 NOx 803 340 3 lt COD 1365 1 025 4 48 4 EC GOP p34 1 5
110. 2001 11 26 GE 42 32 33 103 SOx 008 05 100 NOx 3 33 89 14 O08 21 0 6 0 6 100 COD 1 9 2 116 0 9 829 S24 0 2 0 1 50 552 489 89 21 0 0 8 162 166 102 SOx OS 0 60 NOx 39 3 S36 2 929 1 8 1 9 127 6 2 0 2 0 100 COD SN 21 21 979 17 1
111. Kyowa Pharmaceutical Inc BioWa BIO2004 BioWa BioWa POTELLIGENTW BioWa 2 CC POTELLIGENTW
112. RC 2004 2 14 NGO 50 RC 2004 3 4 4 RC 2 20 RC
113. e 3 2003 2000 4 6 2003 2 2003 CO gt 684 23 CO2 GAR 791 US 0 A 90 95 96 97 98 99 00 01 02 03 FF 304 312 02 90 95 96 97 98 99 00 01 02 03 1
114. nf ST 3 EE GMP 3 1 1 2 2 1 3 ZA
115. COD 1999 2003 eCO2 2000 1999 HP CO2 2001 2004 e SOx NOx 1999 1999 143 120 2003 HP
116. 1 1 mm HHE Em DE PE E L ri 7 1 Li
117. FT II 1964 1977 1979 1996 1997 1998 1999 2000 2002 2003 esd 1 gt COD 8 ISO14001 4 I 1 I 1 0
118. CO2 2 2003 6 CO2 7 121 47 ISO CO2 4 6 98 1
119. 1188 a 055 986 7600 2 my dg 017 949 86 000m2 SOx 6 5 83 NOx 12 12 100 1 0 1 10 2000 5 29 I ME 3 0 2 5 83 COD 1009 5 1 46 89 100 0 5 0 4 84 657 665 101 0 0 1 1 53 Es 072 223 5554 6 28 49 17596 24 000m2 lt SOx 0 0 NOx 0 6 0 4 67 0 0 2000 11 27 014001 11
120. DEHP 2003 6 3 LRI ICCA 4 SOT Society of Toxicology r CHS CS
121. 1980 4 2004 6 oo i _ es B ER 4000tE 3 2004 1994 4 1999 6 2004 6 e Act lp7o Check
122. 24 2009 2003 1 9 3 5 45 69 1
123. Th f EE 2 2 2003 115 1 MR Medical Representatives 0 5 127 3 NN 1 5 224 0 5 000 10 000 15 000 20 000 2004 1
124. e PDCA e 9 ISO14001 e ISO14001 OSHMS RC CSR 2005 4
125. PDCA 2004 6 4 2003 GOP 2003 1 _w 5 GOP 2003 1 2 2 5 2001 2003
126. 500 450 300 200 156 1 147 0 100 55 0 38 1 18 7 9 5 9 9 0 Em 96 97 98 99 00 01 02 03 12 2 PRTR Pollutant Release and Transfer Register PRTR 1 354 PRTR 1 PRTR 8 2003 2003 1 30
127. 375 304 8196 9 6 67 136 660 104 254 76 127 51 40 2548 a EE EE 0930 22 5S500 k6 65 64 98 570 000m2 lt SOx 54 67 124 NOx 12 15 125 2 0 8 67 MWH 2 1 IS014001 2000 9 11 21 23 110 21 COD 172 177 1039 6 157 141 90 6 1 183 6 360 7 420 117 800 434 5496
128. 2 3 0 3 4 1 GLP Good Laboratory Practice 2 GCP Good Clinical Practice LI
129. DAAM DAAM DAAM DAAM ADH 2 03 3510 3560 LIME
130. CUE 1 DEHP 2 Organization for Economic Cooperation and 1 OECD Development 2 HPV HPV 2003 3 SOT 4 42 SPEED98
131. 8 2003 100 0 15 1 000 0 002 3 1 1 1m 0 8 0 013 2004 6 n 120 3
132. BioWa NN 8 II BCAAI BCAA BCAA BCAA
133. 2001 2003 8096 909 99 100 3 3 5 LE 56 GOP
134. 2003 2003 4 2004 3 2003 2003 1 12 2004 3 KYOWA BIO INNOVATOR lt gt P18 P26 P35 lt gt
135. 1970 CO2 1981 86 1993 1996 1997 1998 1999 2000 2001 2002 2003
136. 1977 mG 26 0 15 2003 1 1 1999 1999 1999 930 1 800 62
137. e PCB 12 2003 MSDS PRTR MSDS
138. 0 1 0 09 90 COD 3 5 8296 21 4 3 7596 1 600 0 3 0 1 33 674 544 81 16 8 50 IS014001 IS014001 i tu IS014001 H ISO014001 4041 029 888 8001 210 000m2 2000 3 21
139. ADCC POTELLIGENT BioWa Inc 1 ADCC EZR Ei Antibody d d llul ICi ee 03 3282 0980 2 SI me r A a ee B F im Tp a 1 1 Aa 1 VV lt E 2003 2 BioWa
140. 3 PDCA P 0 12 12
141. _ USA _ _ 85 _ _ _ _ 2 3
142. 8 P25 43 8 P12 19 P32 46 P14 19 O EBM Evidence Based Medicine EBM gt P22 23 P25 27 1 ISO14001 5 2 OSHMS Occupational Safety and Health Management System 6
143. 209 X 03 02 2003 52 4 0 7 e COD 651 413 1 365 39 COD 3 990 471 93 169 0ZSI e 20 5 2 6 11 48 s SOx 1 072 157 13 2 595 s NOx 609 55 8 803 25 4 14 340
144. WWF JAPAN lt gt 2002 2002 4 1 2003 3 31 2003 2003 4 1 2004 3 31 a 1 2 oxo process
145. 1
146. 360
147. 2003 2003 18 158 90 10 2003 50 708 01000 OO ee OO ae 227 312 2 27 1 200 000 203 874 1 961 193 570 2 000 2 1 408 es oooo0 0
148. 12 2002 2003 a 1 182 5 095 289 4 430 COD 263 1 690 S 1 568 130 571 37 521 282 500 46 495 SUT 4 2 1 846 0 2 0 35
149. 2004 2 6 2 2 2 x RT 3 7 1 684 1990 2 8 1 0 0 95 QQ 2010 CO2 1990 2 _ 158 1998 50 0 85 0 65 P42 43 708 50 0 056 0 029 8 2007 88 2004 400 2007 250 _ 9 9 1996 97 6 lt gt 2P46 1 072 13 3 5 3 0 609 8 1 4 1 3 25 14 0 68 0 58 58 6 7 3 7 3 9 lt 2P41 651 9 3 0 1 8 471
150. 16 1 8 1 5 8 20 5 11 1 0 0 8 8 3 2 2 x P32 _ CO2 2000 4 6 P32 40 619 2010 100 P48 i Cd 2 2 1 WI 3 5 x 4 p34 56 O LCIA 7 LCA P19 35 8 P34
151. 38 4 13 2 PRTR 1 200 EED2OCKNRP TEE 154 2 120 80 97 98 99 00 01 02 03 PRTR 1 160t 2003 PRTR 1 i Sa 70 22 oe oo ee _85 0 8 0 8 0 0 0 0 95 999 090 1 00 1 6 99 47 00 00 00 100 8 0 0 5 OO 113 1 4 106 00 00 00 II2 2 391 0 0W 00 121 08 08 0 0 0 0 172 NN 9229 0 90 0 217 1 5
152. 2003 2004 3 1 5 1 89 6 3 _ _ _ Hakko Europe _ _
153. OECD CCA HPV 2 LRI HPV 2 1 UNEP JETOC 11 3 6 2000 9 2 DEHP DEHP 2003 1
154. _ 158 2004 2003 708 500 709 2003 2004 2004 250 2003
155. COD 39 169 119 e 3 7 50 e 20 350 304 8 662 849 2 CO2 8 2 CO2 CO2
156. elGA22 0 2 gt GP P34 e e 9 1
157. A 8 i 2 9 6 NONE ISO 3 1 2003 2 2 2 6 1 2 2 4 1 3 a
158. 1 2 3 VXNANTNCIK wh 1 1 me a 0835222511 42 229 215 940 870 000mS lt SOx 1 164 996 86 NOx 302 265 88 11 9296 IS014001 1999 7 26 8 21 21 100 COD 612 325 53
159. 1 4 100 CO 65 S x1 290 a 55 4 gt 12 000 gt 56 000 ke 16 000 ke 620 x1 69 0 5 1 2 LCA 2003 10 LCA Environmental load of 4000 social stocks 1998 739 CO gt
160. 15 OR 1 4 1 gt 10 2 gt 5 575 2002 18 1 5 gt a sa 3 I gt e6 1 http www kyowa co jp kankyoj er2002j pdf
161. 24 0 35 HX 2003 3 5 2002 3 COD 63 13
162. 69 2Au 6 3u 3 7 5 5 11 600w 196 e 166D 4p 2 8 0 4 lt 158 95 1998 50 2004 1998 2004 50 708y 700R 50 88 2007 250
163. lt 2003 1 3 3
164. 2001 2 O X 2004 3 1 A 6 ni 4 50 5 2004 COD 3 7 CO2 1990 ED 00 O P10 O 95
165. 1000 708 98 99 00 01 02 03 1
166. 2003 1R 2 Neea MM ag 20c 3 348 838 359 285 26 836 16 089 10 017 8 485 9 041 11 791 11 358 14 768 29 206 31 438 361 096 368772 13 358 51 969 225 042 219 047 6 294 6 749 1 23 0 19 4 522 6 505 4 7 5 7 5 ROA 2 74 2 ROE 4 51 3 94
167. COD 5 000 rg 130 TN TP 17 3 44 CO gt SOx 410 2 NOx 300 12 2 70 6 700 ke 120 1 600 35 600 11 mm mm COD 42 000 e 470 TN TP 430 16 79 40 a CO SOx 210 990 NOx 260 11 23 2 480 42 000 COD 2 900 gl 31 TN TP 4 0 2 12 CO SOx 16 62 NOx TFke 19 1 3 1
168. KYOWA KYOWABIO INNOVATOR 4 21 gt P23 lt gt P22 P16 17
169. 0 9 0 0 0 0 223 8 5 5 U I IIS200 00 00 227 91 0 06 00 00 232 32M 00 1 00 1 00 272 22 70 6230 00 00 00 297 MO 0 0 9 299 1 8490 06 00 00 310 9 ON ON RO 312 76 3800 0 44 00 00 313 2985 MOUI 00 66 So OA ON OD 179 mg TEG 97 1 2 7 9000 1 VOC 1997 430 2003 VOC 7 2003 PRTR Ho ES 2 6 NXTNCIK 2000 17
170. 2 NN 7 4 N a Oo OR 8 WuxiKyowa Food Co Ltd 120km 1 999 A
171. 20 AG 126 1 16 2003 11 600
172. 72 4 0 8 20 1 312 980 75 101 38 389 m 6 78 166 96 SOx 0 5 2 2 100 NOx 264 267 94 12 oN eC 4 1 3 0 74 COD 4 09 107 46 4 5 125 3 2 67 46 25 42 519 929 174 83 48 42 20 1 3 8 66 SOx RO 0 80 NOx 8 1 7 6 94 0 2 G2 MOO S00 166 5596 COD 5 O22 0 04 15 65 56 86 gi 269 FT AV
173. kyowa cO jp e http www kyowa co jp 100 6 1999 3 6 SOYINK 3
174. 0 2000 2001 930 2003 2 126 P49 2004 30
175. 08 5 OSE 253 912 DO 9 395 1 A 94 777 11 454 17 082 SS 865 543 17 819 SSO NISS 107 465 29 294 28 92 1 25 66O 2 6 336 430 118 431 410 433 959 3 4416 558 74 354 867 624 102 870 1206 388 2 6S2 194 692 195 039 2 268 7 299 MD 7 666 4 2 1 2680 O218 48 5 448 9 449 1 4 945 8 10 0 0 071 9 1 28 I 4 4 62 5 82 216 99 112 7 00 93 203 01 55 160 02 84 268 093 100 99 258 00 289 01 292 02 314 03 292 2
176. 2004 1 0 19 2007 2000 25 0 1 250 2003 16 030 10 1 13 4650 1996
177. ntation Industry Ltd AGROFERM Select Supplements Inc SSI Kyowa Pharmaceutical Inc Kyowa Hakko U K Ltd 9 BioWa Inc kKyowa Hakko U S A Inc Kyowa Hakko Europe GmbH Kyowa Hakko U K Ltd Kyowa lItaliana Farmaceutici S R L Kyowa Hakko H K Co Ltd Kyowa Hakko Industry Singapore Pte Ltd BKyowa Hakko Thailand Ltd Kyowa Hakko Malaysia Sdn Bhd Kyowa Pharmaceutical H K Co Ltd 4 3 Degussa AG 2004 6 30 1 Agroferm Hungarian Japanese Fermentation Industry Ltd
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