No.33
Contents
1. 2 GHD Growth Hormone Deficiency New Approaches to the Diagnosis Gerhard Binder MD PhD GHD2. GH GH 18 24 18 24 140 120 3 120 100 100 80 TT 60 60 40 40 20 20 0 T T T T T T T 1 0 T T T T T T T 1 PF RP GH VT SF RE MH BP PF RP GH VT SF RE MH BP QOL 18 24
3. GH GH
4. 10 15 16 74 8 4 Department of Pediatrics Ambroise Pare University Hospital Boulogne Billancourt France 56 4
5. 10 12 12 14 BMI 18 BMI 17 1849kg m BMI 16 1699kg m oo DEXA
6. 1cm 20 000 40 000 QOL 17 60 32 82 4
7. i oO f DH B4 i
8. GHD GHD GH true positive GH 1985 2005 GHD 349 297 true negative 108 SGA IGF I IGFBP 3 GH IGF I IGFBP 3 GHD IGFBP 3 GHD IG
9. Choquet GH GHD GH GH GH Lagrou GHD GH
10. 3 M 3 50 80 Tanner
11. mini puberty 1Professor Emeritus University of Texas at Austin amp Research Professor Tarleton State University Stephenville TX Professor of Clinical Pediatrics Riley Hospital for Children Indiana University School of Medicine Indianapolis IN amp Professor Emeritus University of Virginia Charlottesville VA USA
12. 1SD 340g 220g F 10 16 17
13. No 32 p 3 17 16 gt 8 CR during Childhood Experience of Adolescence in Patients Treated With GH Chantal Stheneur MD PhD Marc Sznajder MD Melissa Taylor MD Bertrand Chevallier MD 20 GH 15 2 QOL SF36 QLS_H SF36
14. GH GHD A 10 000 children with TEST short stature are tested Sensitivity 84 Specificity 76 GHD 1 4000 9910 without GHD 90 with GHD Short stature 1 33 7530 2380 true negative false positive 5680 1850 Uue negative false positive 1810 true negative 80 true positive true positive 5 5 false negative 70 true positive 70 of 640 test positives are GH deficient 9 9 9340 of 9360 test negatives are GH competent 99 8 10 000 short children with short stature and TEST pathological growth velocity are tested 4000 with GHD 0 0 2 Sensitivity 84 Specificity 76 6000 without GHD 4530 1470 true negative false positive 3440 1090 true negative false positive a 1120 true negative 3360 true positive
15. QOL 8 PF RP GH VT SF RE MH BP 6 Sport Training and the Growth and Pubertal Maturation of Young Athletes Robert M Malina PhD FACSM Alan D Rogol MD PhD FACSM GnRH
16. EEE i TEE REE dln Un EEE LH FSH GnRH EEE REE 60 120 METs METs GnRH
17. GHD GHD GH 6 GH 8 pg L 7 pg L GH 66 kg GH 7 3 g GH GH GH GHD
18. Growjector 791 0395 2131 1 659 0021 3 19 2010 12 19AFBZX00104000 74 JMDN 70391000 BC Bmg BD 3 659 0021 3 19 960 2152 1 2010 4 3 OT 242 1 1209 KO 12 MED 102 0074
19. 8 QLS H GHD 9 81 65 35 65 538 1 1 GH 24 17 22 5 48 9 37 5 15 62 5 82 8 3 15 5 3 3 151 2 1
20. GH GHD GH GH GH ESPE GH 20 pg L 40 GH GH 3 5 GH 314 EIA 9 GHD GH 7 g L 1
21. UN28B 6q21 9q31 2 EI 95cm 8 3cm 2 13cm 13 15 11 0 DEE
22. 20 36 44 889 GH SF36 QOL 85 GH GH GH
23. true positive 540 100 false negative 2820 true positive 2820 of 3170 test positives are GH deficient 89 5650 of 6830 test negatives are GH competent 82 7 GH 3 1 33 1 GHD 4 000 1 2 GH 84 76 3 25 40 GHD A 10 000 2 10 B 10 000 2 89 1 700BZZ00479 74 MPN 70394000 BC Bmg
24. 4 2 15 MediArt Ltd 2012 9 1
25. 16 8 4 7 p 0 19 19 3 5 18 4 2 6 197 46 p 0 32 QOL SF36 PCS MCS 160cm 18 24 SF36 QLSH 620 335 315 44 2 GHD SGA QLSH GH GHD SGA QOL
26. B5 Female Athlete Triad LH
27. 00 98 GHD 0 GH GH 13 1 MI ES EE GH 33 20 pg 7 pg CR GH H 40 a GH University Children s Hospital Pediatric Endocrinology Tuebingen Germany GH GHD
28. EF 1 IGEFBP 3 IGEF 1I 1 4SD IGFBP 3 0 2SD 100 sensitivity specificity 35 2 4 0SD 1GF I GH ke GH ROC GH 6 6 gg L GH 7 3 ug L accuracy true positive true negative GH GH
29. Original Article Pediatric Endocrinology Reviews PER Volume 9 No 1 amp Supplement 1 2011 elire IaE Ial jpW MKelge a IP alP aRe Associate Editor Mitchell E Geffner MD atelejleli f elire Wo eelelaWelate llelojiileWNuclopM Kolatel oiWConialtel MD PER published by Y S MEDICAL MEDIA Ltd ICHNDOOMN NO 2 Chantal Stheneur MD 2 Marc Sznajder MD Melissa Taylor MD Bertrand Chevallier MD 2 Robert M Malina PhD FACSM Alan D Rogol MD PhD FACSM CHD 3 Gerhard Binder MD PhD PER Volume 9 No 1 amp Supplement 1 GH QOL GHD
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