Integrity User Guide
Contents
1. AYuABaJUI SONSIOS SNOYd E User Guide User Guide Mintegrity TABLE OF CONTENTS v Introduction About Prous Science Integrity Content Technology How to Use this User Guide v Getting Started System Requirements Browser Requirements Display Plug ins Chemical Structure Plug ins Registration and Login Procedure Registered Users Self Registration Terms of Use Support v Integrity Home Page Today s News The Starting Line Pipeline on the Move Gateways to Targets Gateways to Patents Gateways to Clinical Trials Conferences Integrity Learning Center New Features 1 2005 Prous Science User Guide Mintegrity v How to Choose a Search Area Definition of Integrity Knowledge Areas v How to Search Browse Index Concept Search Operators and Wildcards General Text Data Searching Chemical Structure Searching Sequence Searching Quick Search v How to View and Manage Results Results Formats Sorting Results Statistics v Query Manager Alert Center Saved Query Alerts Keep Me Posted Alerts Controlled Vocabulary Alerts Session History v Printing and Exporting Results Printing Results Exporting Results v How to Contact Prous Science 2 2005 Prous Science User Guide Biintegrity v INTRODUCTION About Prous Science Integrity The amount of drug discovery and development information available is growing exponentially It is estimated2. related information for the entire set of products displayed on screen Sorting Results Results displayed in list format can be sorted by clicking the underlined column headers In columns with text data click an underlined column header to sort the data in ascending alphabetical order In columns with numeric data click an underlined column header to sort the data in ascending numeric order 23 2005 Prous Science User Guide Mintegrity Statistics Integrity has a feature for graphical representation of search results From a results display click the Options pulldown menu on the upper right and choose Statistics A list of Available Charts appears Click one of these options to view a chart representation of your search results Three types of display are available in Integrity Charts Horizontal Display the default display type Vertical Display and Pie Chart Display Click these buttons to alternate between display types In the two dimensional Horizontal and Vertical Displays click the up down and left right arrows to scroll through the complete data set and display all categories of information To go to a single subset of the data shown in the chart click the corresponding bar To go to multiple subsets click the checkbox next to the bars of interest and then click the button for View Subset s In the three dimensional charts e g Therapeutic Impact by Organization click the eye icon next t
3. studies on targets or on target proteins and genes added to Integrity are presented weekly and are easily accessible from the Integrity Home page or the lefthand frame of the Targets Knowledge Area Gateways to Patents Gateways to Patents presents the latest in intellectual property portfolios added to Integrity New patent information added to Integrity is easily and rapidly accessible from either the Integrity Home page or the lefthand frame of the Patents Knowledge Area 12 2005 Prous Science User Guide mintegrity Gateways to Clinical Trials Gateways to Clinical Trials is an update of the most recent clinical trials cited in current biomedical and congress literature and company communications added to Integrity The information is presented in tabular format with columns for study name condition and product It can be accessed from the Integrity Home Page or the lefthand frame of the Clinical Studies Knowledge Area Conferences Links to information presented at key conferences in the drug R amp D field are provided on the Integrity Home Page and from the lefthand frame of the Literature Knowledge Area Integrity Learning Center The Integrity Learning Center provides case studies on how to use the Integrity portal efficiently and obtain the maximum benefit from data retrieved Periodically the Learning Center adds detailed case studies for Integrity explaining search strategies data
4. that within the next two years as much scientific data will be generated as has been in all of history to date To counter this information overload investigators need tools to filter the reliable and validated information upon which subsequent actions can be based With this premise in 2001 Prous Science launched Integrity the world s first drug discovery and development Internet portal to integrate the diverse knowledge areas of drug discovery and development Using the most advanced Internet application technologies and search capabilities Integrity empowers researchers to find manage and correlate information from all knowledge areas providing quick and easy access to new and relevant data Forged by insight from more than 40 years of biomedical content development the Integrity portal takes knowledge management for the pharmaceutical professional one step further By anticipating trends in drug discovery and marketing and translating these needs into next generation information tools Integrity provides users with a dynamic resource to make better decisions and drive higher quality results from discovery to market in less time A relentless focus on content quality and product enhancement makes such foresight possible Prous Science continually works to improve Integrity to provide the drug R amp D field with the best drug discovery informatics portal by adding the newest computing hardware data content and tools to supp
5. use Integrity after you have registered the first time type your User Name and Password in the spaces provided under Registered Users and either click Login or press Return Terms of Use Access to Integrity is offered on the condition that you accept without modification the terms conditions and notices contained in the Terms of Use document Use of Prous Science Integrity constitutes agreement to all such terms conditions and notices Registered users can consult the Terms of Use by clicking the link found on the Integrity Login page or if inside Integrity by clicking Support Help and then clicking Terms of Use 10 2005 Prous Science User Guide Mintegrity Prous Science is the creator compiler producer and publisher of Prous Science Integrity and therefore is the exclusive holder worldwide of all intellectual property rights copyrights trademark rights and database sui generis rights on Prous Science Integrity and on any of its elements in any language including but not limited to any know how operating source code database data design image audio and literary elements accessible through Prous Science Integrity and or through which Prous Science Integrity operates except where expressly stated otherwise Support Contact Integrity Support for technical assistance to request information on content or features or to forward suggestions for Integrity The Support Help button found i
6. Knowledge Area the Printer friendly Format option is found in the Table of Contents third from the bottom Exporting Results All Knowledge Areas of Integrity except Organic Synthesis and Disease Briefings have an option for exporting data in a spreadsheet Excel or word processor Word format In the Drugs amp Biologics Knowledge Area results can also be exported in BizInt Smart Charts format and SDFile format To export results open the Options pulldown menu and select Export Center A dialog box opens Select the Export Type and then select the fields to be exported Next select the number of pages to be exported up to 100 records can be exported in a single operation you can select individual records to be exported by using the record checkbox feature next to each record following the instructions provided in the dialog box Finally click Export 27 2005 Prous Science PROUS SCIENCE ii G id Mintegrity ser Guide v HOW TO CONTACT PROUS SCIENCE Send questions comments and suggestions to Integrity Support by completing and sending the Help Request Form found under the Support Help button or by e mailing integritysupport prous com Prous Science S A Provenza 388 08025 Barcelona Spain Tel 34 93 459 2220 Fax 34 93 458 1535 Prous Science URL http www prous com Prous Science Integrity URL http integrity prous com Prous Science Integrity SSL URL https integrity prous com Integrity Su
7. an include bioactive compound criteria Information on patent literature related to drug discovery and development Searches can include bioactive compound criteria 2005 Prous Science User Guide Biintegrity v HOW TO SEARCH After logging on to Integrity and selecting a Knowledge Area you are taken to the Search Form for the Knowledge Area selected Each Search Form contains a series of search fields that are grouped into Sections such as Product Target Reference Patent Organic Synthesis Experimental Pharmacology Pharmacokinetics Metabolism Clinical Studies Companies amp Markets and Disease Briefings Each Integrity Knowledge Area contains a combination of two or more Sections that can be used for simple or complex searching schemes using Boolean logic search operators AND OR On the left of each search field line is a pulldown menu with the default heading of Select Value or Optional Value that allows you to choose a specific search field Next to the pulldown menu is a blank field where you can enter search terms manually or select from a Browse Index To the right of each blank field is a rectangular Index button that opens a Browse Index of vocabulary for the search field chosen with the pulldown menu To the right of the Browse Index button is an interfield operator button that allows you to combine search fields using Boolean logic AND OR At the top right corner of the Search Form are a Clear b
8. arch in Integrity ae oe Go to the Targets Knowledge Area Select the Target Section Open the pulldown menu of the first search field line and select Sequence Type or paste a gene or protein sequence or sequence fragment in the blank field to the right of the pulldown menu this search field is not case sensitive 21 2005 Prous Science User Guide Blintegrity Do not use wildcards Truncation is automatic on the left and the right of the sequence 5 If you wish to add other criteria to the search strategy go to the next search field line in this Section or go to the first free search field line in any other Section of the Search Form and enter the necessary data 6 When your search strategy is complete on screen click the Start button at the top of the Search Form The results of your search appear on screen in a table or record format depending on the number of records retrieved by the search Quick Search The Quick Search feature can be used to retrieve terms across all Integrity Knowledge Areas To perform a search type the string you wish to find in the Quick Search box and click Go A scheme appears that shows the results found in the various Knowledge Areas Click a Knowledge Area bar to see results for that Knowledge Area click the Related Info button next to each Knowledge Area to display the set of related information associated with the record set retrieved for that Knowledge Area Tip D
9. armacokinetics metabolism with data on parent compounds and active metabolites e Comprehensive information on more than 30 000 references to clinical studies of compounds currently under study and or use in humans e A background reference to more than 80 disease entities with full color multimedia illustrations e Information on more than 1 000 organizations active in the drug discovery and development fields e More than 575 000 references to current literature abstracts and proceedings from congresses and symposia as well as company communications and e More than 70 000 patent families from 11 leading sources including EP JP US and WO Technology The Integrity portal incorporates the latest database technology for managing text data and image information The chemical structures available in Integrity are managed using the CambridgeSoft Corporation CS ChemOffice Webserver and the ChemAxon JChem applications Integrity is available for consultation 24 hours a day 7 days a week and 365 days a year In order to provide the highest quality of service Integrity servers are 5 2005 Prous Science User Guide Mintegrity i operated from a secure temperature controlled environment with back up power supplies located on site The incorporation of the latest redundant and hotswap hardware prevents hardware failures from affecting end user access to the portal All of this creates the highest le
10. diates reagents and end products of synthesis processes Searches can include criteria for end products or literature or patent references associated with the syntheses Information on pharmacological activity screens and assays of bioactive compounds Searches can include criteria for bioactive compounds tested or associated literature references Information on pharmacokinetics studies of bioactive compounds Searches can include criteria for associated literature references Information on clinical studies of bioactive compounds Searches can include criteria for bioactive compounds tested or associated literature references Disease Briefings by name or content full text Searches can include bioactive compound criteria 2005 Prous Science Mintegrity Knowledge Area Companies amp Markets Literature Patents Information Type Essential information on active organizations in the pharmaceuticals biotech field References to the current literature abstracts and proceedings from congresses and symposia and company communications References to the most recent patent literature from 11 leading sources reflecting drug research activity throughout the world 16 User Guide Use To Search For Information on overall company sales revenues sales of launched products products in development and new patents Information on biomedical literature congresses and company communications Searches c
11. found in the standard CS ChemDraw Manuals To display or download a manual in PDF format click the 8 2005 Prous Science User Guide Mintegrity i appropriate version of CS ChemDraw in the CS ChemDraw Manuals table at http www cambridgesoft com services documentation manuals desktop cfm ChemAxon Marvin Applet An alternative chemical structure search feature available in the Drugs amp Biologics Knowledge Area of Integrity is a ChemAxon JChem application To utilize this chemical structure search function you must have the Marvin applet installed on your computer The Marvin applet downloads automatically when you connect to the Marvin structure search page inside Integrity Registration and Log on Procedure Depending on the type of access that has been licensed by your organization you will either be provided with a User Name and Password combination or be advised to self register the first time that you use Integrity If a User Name and Password have been provided to you by your system administrator follow the instructions outlined in the Registered Users section below First time users without a User Name and Password should follow the instructions under Self Registration below Registered Users To use Integrity go to http integrity prous com for an SSL connection go to https integrity prous com Type your User Name and Password in the spaces provided and either click Login o
12. g box select the changes to be monitored select an Alert frequency daily weekly or monthly and click Create Alert The Alert is stored in your personal Query Manager Alert Center From the Query Manager Alert Center you can display the set of records on which the Alert has been established i e Execute delete it and view the details The View Details option allows you to change the alert frequency the changes being monitored or even the name and description Controlled Vocabulary Alerts Controlled Vocabulary Alerts are established to detect new controlled vocabulary terms for certain fields in Integrity These Alerts are established from inside the Query Manager Alert Center and allow you to be notified by e mail when new terms for Mechanisms of Action Therapeutic Groups Conditions Organizations and Natural Sources appear in the Browse Indexes Session History The Session History feature is found inside the Query Manager Alert Center of Integrity It tracks queries run in Integrity during the last 24 hours Use this feature to review results from an earlier query or to save a query not saved when it was generated You can set up an Alert when saving the query 26 2005 Prous Science User Guide Mintegrity v PRINTING AND EXPORTING RESULTS Printing Results To print results from Integrity in a report format open the Options pulldown menu and select Printer friendly Format In the Disease Briefings
13. in Integrity are 14 2005 Prous Science Mintegrity User Guide Knowledge Area Drugs amp Biologics Targets Organic Synthesis Experimental Pharmacology Pharmacokinetics Metabolism Clinical Studies Disease Briefings Information Type Essential information on drugs and biologics in the drug R amp D pipeline Coverage of genes and their related proteins as targets for drug discovery Routes of synthesis schemes intermediates reagents end products for drugs currently on the market or in development worldwide Data from experimental studies that delineate drug receptor and enzyme target cell interactions Data from experimental and clinical studies that delineate a drug s absorption distribution metabolism and excretion ADME profile Comprehensive information on clinical trials of drugs currently under study or in use in humans Dynamic executive summaries on the current status and future trends in drug therapy for specific diseases 15 Use To Search For Information on bioactive compounds Searches can include criteria for targets or literature or patent references associated with the compounds Information on gene proteins and physiopathologic processes as targets for therapeutic intervention Searches can include criteria for product literature or patent references associated with the targets Information on drug synthesis routes chemical interme
14. in applet installed on your computer The Marvin applet downloads automatically when you connect to the Marvin structure search page inside Integrity 20 2005 Prous Science User Guide Mintegrity Take the following steps to run a substructure or combined search in Integrity Go to a Knowledge Area Click the Structure Search bar that is next to the Product or Organic Synthesis Section The Structure Search Form opens If you are in the Drugs Biologics Knowledge Area you are taken to the structure search option that you last used CS ChemDraw Plugin or Marvin applet If you wish to change to the other option click the link below the drawing window Use the toolbar to draw a structure Depending on the structure search tool in use there are a variety of right click options toolbar options and menu options available for determining your structure search strategy To add text or data criteria to your search strategy go to a search field line and enter your term s as described under General Text Data Searching When your search strategy is complete on screen click the Start button at the top of the Search Form The results of your search appear on screen in a table or record format depending on the number of records retrieved by the search Sequence Searching You can search by protein or gene sequence in the Targets Knowledge Area of Integrity Take the following steps to run a sequence se
15. links and other utilities using practical examples New Features The new features section of the Integrity Home Page presents the latest enhancements in Integrity ranging from new content to technological innovations and new features 13 2005 Prous Science PROUS SCIENCE i G Mint grity User Guide v HOW TO CHOOSE A SEARCH AREA When you log on to Integrity you are taken to the Integrity Home Page which provides gateways to the most recent and relevant content and access to the Knowledge Areas that are the entry points to searching and retrieving information Choosing a Knowledge Area does not affect your access to the complete set of data in Integrity because the data are fully integrated Results displayed are linked to additional information that can be found in the other Knowledge Areas Choosing a Knowledge Area determines a starting point for your search and the type of results you will view first You can go to a new Knowledge Area at any point from the Integrity Home Page from the Search Forms and from the Results Displays Each Knowledge Area is composed of Sections that allow you to develop search strategies to retrieve data of interest For example the Drugs amp Biologics Knowledge Area allows you to combine search criteria from four sections Product Target Reference and Patent Definition of Integrity Knowledge Areas The Knowledge Areas available for searching and retrieving information
16. mine if the version installed works in Integrity by executing a simple structure search If there is not a prior installation of the plug in or if the structure search does not appear to work correctly click the CS ChemDraw Net Plug in link that appears just below the structure drawing window A window appears with your user data confirm these data and then click Download and follow the instructions that appear If there are any questions during this procedure or if the structure search does not appear to work correctly please contact Integrity Support see How to Contact Prous Science Tip If the CS ChemDraw toolbar does not appear when you go to the Structure Search Form hover your mouse in the structure drawing window and right click From the menu provided select View then select Show Main Tools The toolbar appears For information and documentation on the CS ChemDraw Plugin first verify which version of the plugin you have installed this can be seen in any Structure Search Form in Integrity right click in the structure drawing window select Help and then select About ChemDraw note the version number that appears Then go to http www cambridgesoft com services documentation manuals desktop cfm and select the appropriate version number of the CS ChemDraw Plugin from the CS ChemDraw Manuals table The CS ChemDraw Plugin does not have a separate manual Information on structure drawing conventions can be
17. n Integrity gives access to a Help Request Suggestion Form that auto completes with user data Alternatively inquiries can be sent directly to integritysupport prous com When submitting a request for technical support please include the following information 1 Operating system in use e g Windows 2000 Windows XP Mac OS 9 2 2 2 Browser type and version including any service packs e g Netscape v 7 Internet Explorer v 6 0 and 3 Details on the search that was run and the results obtained wording of any error messages that appear 11 2005 Prous Science User Guide Mintegrity v INTEGRITY HOME PAGE When you log on to Integrity you are taken to the Integrity Home Page which provides direct links to recent and relevant content in Integrity and access to the Knowledge Areas that are the entryways to information retrieval in the portal Today s News Every business day Today s News presents a sampling of current news in drug R amp D The Starting Line An alerting service from Integrity presenting a table updated weekly of the most promising compounds entering preclinical development lead compounds and new mechanisms of action Pipeline on the Move A weekly alerting service from Integrity presenting milestones detected in the status of drugs currently under active development Gateways to Targets Gateways to Targets present areas of potential therapeutic intervention New
18. nother term to this field click the Browse Index button again and choose a new term The new term is copied into the Search Form with an OR operator You can manually change the OR operator to AND 6 Not all the search fields in Integrity have a Browse Index of terms Some Browse Index buttons provide a description of the type of search term that Should be entered manually in this field which format to use and which operators and wildcards are valid 7 Use of the Browse Index feature wherever possible is strongly recommended however you can also manually type search terms in the blank field Take care to use operators and wildcards as necessary Valid wildcards are for a single character and for multiple characters the wildcards can be combined or used multiply in a single word or term 8 If you wish to add other criteria to your search strategy go to the next search field line in this Section or go to the first free search field line in any other Section of the Search Form and repeat this procedure You must choose at least one search field and enter a search term for that field in order to launch a search however it is not obligatory to enter data in more than one field 19 2005 Prous Science User Guide Mintegrity 9 When your search strategy is complete on screen click the Start button at the top of the Search Form The results of your search appear on screen in a table list or record format depending
19. o not use hyphens or apostrophes when searching in the Quick Search instead use an asterisk as a substitute for one or more characters An asterisk can also be used as a truncation indicator on either the left or the right 22 2005 Prous Science User Guide Mintegrity v HOW TO VIEW AND MANAGE RESULTS Results Formats When your search strategy is complete on screen click Start The results of your search appear on screen in a table list or record format depending on the Knowledge Area chosen for your search and the number of records retrieved by the search If results are displayed in a table or list format click the product or reference links in the table or list to view individual records When full records are displayed at the bottom of each record is an area with the heading Related Information This area contains a series of links to related information on this record that can be found in the other Knowledge Areas of Integrity Click these links to view this related information To select other display formats click the Options pulldown menu on the upper right and choose a new format e g Full Records Product List with Structures Gateways to Development Status Structure Activity Patent List with Structure When in a list format use the checkbox found next to each record or line to restrict the option applied to the set of records checked The All Related via Quick Search option takes you to all
20. o one or more rows to eliminate them from the display to better view nearby information To go to a single subset of the data shown in the chart click the corresponding bar To go to multiple subsets click the checkbox for the rows of interest and then click the button for View Subset s Click the button for Print Chart to print the chart displayed 24 2005 Prous Science User Guide Mintegrity v QUERY MANAGER ALERT CENTER The Query Manager utility allows you to save search strategies as saved queries and rerun them in a future session The Alert Center utility allows you to program searches to be run automatically at daily weekly and monthly intervals with notification via e mail of new and updated information added to Integrity The Query Manager Alert Center also includes a Session History feature There are three types of Alerts that can be established in Integrity Saved Query Alerts Keep Me Posted Alerts and Controlled Vocabulary Alerts When new or updated results are detected in Integrity you receive notification by e mail Clicking a Follow this link text in the e mail message launches your browser goes to Integrity requests you to log in and then displays results The e mail notifications contain a link to display only new results as well as a separate link to display all results should you so desire Saved Query Alerts Saved Query Alerts are established to detect new records in Integrit
21. on the number of records retrieved by the search Tip The search engine is not case sensitive so searches for Parkinson and parkinson retrieve the same records Chemical Structure Searching Integrity has a chemical structure search feature that allows you to search by product substructure in the Product Section of the Drugs Biologics Experimental Pharmacology Pharmacokinetics Metabolism Clinical Studies Companies Markets Disease Briefings Literature and Patents Knowledge Areas and for products or chemical intermediates in the Organic Synthesis Knowledge Area You can combine substructure searches with text and data searches One of the chemical structure search features of Integrity is a CS ChemOffice Webserver application To utilize this chemical structure search function you must have the CS ChemDraw Pro Plugin or the CS ChemDraw Net Plugin installed on your computer The Net Plug in can be downloaded at no charge via the link provided in Integrity Use this plugin to run substructure searches in the Drugs amp Biologics Organic Synthesis Experimental Pharmacology Pharmacokinetics Metabolism Clinical Studies Disease Briefings Companies Markets Literature and Patents Knowledge Areas An alternative chemical structure search feature available in the Drugs amp Biologics Knowledge Area is a ChemAxon Jchem application To utilize this chemical structure search function you must have the Marv
22. ort analysis and knowledge management This extensively linked network of information provides the right environment for easy and rapid access to drug discovery and development data which makes Integrity an indispensable resource to any drug discovery based pharmaceutical or biotechnology organization Integrity allows quick and easy access to vast amounts of data which in turn can be put into context and turned into knowledge 3 2005 Prous Science User Guide mintegrity It is this knowledge that sparks the inspiration behind tomorrow s breakthroughs in drug discovery Content Integrity offers fully integrated information related to therapies and drug R amp D indispensable to professionals working in all stages of drug discovery development and marketing The depth and breadth of content unmatched by any other resource puts a wealth of refined structured information at the users fingertips fostering innovative decision making Integrity s ten Knowledge Areas are e Drugs amp Biologics Essential general chemical and pharmacological information on bioactive compounds in the drug R amp D pipeline e Targets Target based approaches to disease diagnosis and therapeutic intervention e Organic Synthesis Routes of synthesis schemes intermediates reagents end products for drugs currently on the market or in development worldwide e Experimental Pharmacology Data from experimental studies
23. pport integritysupport prous com 28 2005 Prous Science
24. r press Return This takes you to the Integrity Home Page Note Before logging in first time users should click the Terms of Use to display the guidelines for the use of Integrity Self Registration To register to use Integrity go to http integrity prous com for an SSL connection go to https integrity prous com and click Self Register on the 9 2005 Prous Science User Guide Mintegrity Welcome screen The Terms of Use that apply to your use of Integrity appear on screen Read these terms and click I accept the above Terms of Use to accept these terms then click Continue Complete all the fields in the Registration Form that appears very important write down the User Name and Password that you choose and keep them in a safe place The information entered in the E mail Address field must be a complete e mail address e g name company com The text entered in the Password field and the Confirm Password field must be identical Now click Send If registration is not successful you will receive a message indicating that information is missing from one or more fields of the registration form Click OK to accept this message and then enter the information requested in the appropriate field and click Send If registration is successful a Login screen appears Enter your newly chosen User Name and Password in the spaces provided and click Login This takes you to the Integrity Home Page To
25. that delineate drug receptor and enzyme target cell interactions e Pharmacokinetics Metabolism Data from experimental and clinical studies that delineate the absorption distribution metabolism and excretion ADME profile of a drug e Clinical Studies Comprehensive information on clinical trials of drugs currently under study or in use in humans e Disease Briefings Dynamic executive summaries on the current status and future trends in drug therapy for specific diseases e Companies amp Markets Essential information on organizations active in the fields of pharmaceuticals and biotechnology e Literature References to the current literature abstracts and proceedings from congresses and symposia and company communications e Patents References to the most recent patent literature from 11 leading sources reflecting drug research activity throughout the world 4 2005 Prous Science User Guide Mintegrity Integrity s ten Integrated Knowledge Areas provide information on e More than 220 000 drugs and biologics e Target based approaches to disease diagnosis and therapeutic intervention for more than 3 000 targets e More than 60 000 organic synthesis intermediates from more than 14 000 synthesis schemes e More than 500 000 numerical values from experimental pharmacological studies delineating drug receptor and enzyme target cell interactions e More than 250 000 numerical values on ph
26. that is based on numerical or date values e g in the Patent Publication Date field From 20050101 From To From To indicates the starting and ending points of a search that is based on numerical or date values e g in the Patent Publication Date field From 20050101 to 20050201 The asterisk replaces any number of characters in the search term It can be used on either the left or the right side of a term or on both sides e g in the Drug Name field val sartan alsart 2 The question mark replaces one character in the search term It can be repeated and can appear anywhere in the search term e g in the Drug Name field Aprov l Aprov 18 2005 Prous Science User Guide Blintegrity General Text Data Searching Take the following steps to run a text or data search in Integrity 1 Go to a Knowledge Area 2 Select a Section Click the down arrow to open the first pulldown menu in the Section chosen where it says Select Value Click to choose a search field 4 Click the Index button to open the Browse Index for the search field chosen Some Browse Indexes offer a choice of an alphabetical or a hierarchical display The Lookup function on the left can be used to obtain a short list of available search terms 5 Select one or more terms in the index on the right and click OK to close the Browse Index window and copy the term s to the Search Form If you wish to add a
27. utton for resetting the Search Form contents and a Start button for launching the search defined Browse Index Concept Most search fields in Integrity have an associated Browse Index of the search terms available for use in that field Fields that do not have a Browse Index have a tip indicating how searches should be set up e g YES NO fields or date formats Consult the Browse Index for assistance in choosing search terms to use in search strategies The Lookup function on the left can be used to obtain a short list of available search terms 17 2005 Prous Science User Guide Mintegrity Search Operators and Wildcards You can combine search fields by clicking the appropriate interfield AND OR buttons on the far right side of each search field box on the search screen Using the AND operator searches for the occurrences that meet the criteria of all the fields linked with this operator using the OR operator searches for the occurrences that meet the criteria for at least one field where a term has been entered You can combine terms within a search field to create a logical statement by using the operators and wildcards listed below AND All of the search terms linked with this operator intrafield or interfield must be present in the field OR Any of the search terms linked with this operator intrafield or interfield can be present in the field From From indicates the starting point of a search
28. ve an Internet connection and one of the following Web browsers Netscape 7 0 or Microsoft Internet Explorer 6 0 or higher The Web browser must be configured to accept cookies and it must be JavaScript enabled Display Plug ins Integrity offers a series of features for viewing with the Adobe Acrobat Reader Plugin and the Macromedia Flash Plugin required version Macromedia Flash 7 or higher The plugins can be downloaded at no charge from www adobe com and www macromedia com respectively Other plugins useful for certain aspects of Integrity are Real Audio www real com and Windows Media Player www microsoft com Chemical Structure Search Plug ins CS ChemDraw Plugin One of the chemical structure search features of Integrity is a CS ChemOffice Webserver application To utilize this chemical structure search function you must have the CS ChemDraw Pro Plugin or the CS ChemDraw Net Plugin installed on 7 2005 Prous Science User Guide Mintegrity your computer The Net Plug in can be downloaded at no charge via the link provided in Integrity To install this chemical structure search plugin log in on Integrity go to the Drugs amp Biologics Knowledge Area and click the Structure Search bar to open the Structure Search Form Check under Programs to see if a CS ChemDraw plug in is already installed on the computer it may be an option under ChemOffice or CS ChemOffice If so deter
29. vel of reliability for end users The Integrity portal offers users the option of a standard Internet connection http integrity prous com or a Secure Sockets Layer SSL connection https integrity prous com which encrypts user queries to and replies from the system How to Use this User Guide This User Guide is organized in chapters that describe topics from system requirements to search techniques Each chapter builds on the preceding one with the goal of helping the first time user follow a logical order and allowing experienced users to locate rapidly information of interest A series of Integrity Case Studies are provided online in the portal in the Learning Center accessed from the Integrity Home Page to assist users in becoming familiar with Integrity 6 2005 Prous Science User Guide Mintegrity i v GETTING STARTED System Requirements To access the Integrity portal on the Internet you must have a standard computer with an Internet connection The speed of access depends on the type of Internet connection that you use We recommend that you install Microsoft Office 2000 or higher for handling data exported from Integrity in Word and Excel formats and a chemical structure database management program for handling SDFiles e g CS ChemFinder MDL ISIS Base Additional requirements or suggestions are provided below Browser Requirements To access Integrity you must ha
30. y To establish a Saved Query Alert run a search in Integrity From the results display open the Options pulldown menu and select Save Query A dialog box opens Enter a Query Name and Description in the dialog box select an Alert frequency daily weekly or monthly and click Save Query The Alert is stored in your personal Query Manager Alert Center From the Query Manager Alert Center you can re run the Saved Query i e Execute delete it copy it back into the search form i e Edit and add additional search criteria and view the details The View Details option allows you to see the results obtained number of records when the query was created and when it was last performed as well as to change the alert frequency or even the name and description You can also save queries and set up Alerts for information that has not yet entered Integrity such as for forthcoming congresses To do this run your search and then click Save Query when the O results message appears 25 2005 Prous Science User Guide Mintegrity Keep Me Posted Alerts Keep Me Posted Alerts are established to detect updated records in Integrity You can establish a Keep Me Posted Alert from a results display at any point in time First select the record or records for which you wish changes to be monitored Then open the Options pulldown menu and select Keep Me Posted A dialog box appears Enter an Alert Name and Description in the dialo
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