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8. Her professional interests include the links between opiate use and crime the epidemiology of drug misuse and the relationship between science and policy in the drugs arena Addiction Why did you leave South Africa and experience as a clinical psychologist meant that I come to London knew something about drugs in the late 1950s Joy Mott I left in 1957 intending to stay in and early 1960s amphetamines were often pre Britain for a year or two get a research job scribed for the treatment of minor depressions broaden my experience and to do some travelling Mi HM My first jobs here included 18 months as a research assistant to a psychiatrist working on Getting into drugs research depressives sleeping patterns and then a year as a clinical psychologist at a neurological hospital A What was your first drugs project JM The first drugs project I worked on was a A What was your training description of drug offenders appearing before the JM I did an Arts degree at the University of London juvenile courts between 1965 and 1968 Natal in Pietermaritzburg and then went on todo The magistrates were concerned about the increas a Masters in Psychology This involved writing a ing numbers of drug offenders appearing before 2 I MT 12 WILEY ff ONLINE LIBRARY Reference Works Wiley Online Library offers online versions of many renowned and indispensable Reference Wor
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10. September 2009 ARTICLE TOOLS 4 Get Article PDF 689k Save to My Profile Additional Information Show All 5 ad E mail Link to this Article How to Cite Author Information Publication History Funding Information 4 Export Citation for this Article Request Permissions 6 Previous Next e Full Article HTML References Supporting Information Cited By View Full Article with Supporting Information HTML Get Article only PDF 689K Keywords chaperone export SecB site directed spin labeling EPR protein protein interaction galactose binding protein OmpA Abstract SecB a remarkable chaperone involved in protein export binds diverse ligands rapidly with high affinity and low specificity Site directed spin labeling and electron paramagnetic resonance spectroscopy were used to investigate the surface of interaction on the export chaperone SecB We examined SecB in complex with the unfolded precursor form of outer membrane protein OmpA as well as with a truncated version of OmpA that includes the transmembrane domain and lacks both the signal peptide and the periplasmic domain In addition we studied the binding of Sech to the unfolded mature form of aalactose hinding nrotein a soluble nerinlasmic orotein We have nreviously used the same strateny ta man CrossRef is a collaborative Abstract Full Article HTML References Supporting Information Cited By Commentary cana reference linking serv
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14. with the unfolded precursor form of outer membrane protein OmpA as well as with a trun areata transmembrane domain and lacks both the signal peptide and the periplasmic domain In addition we stu Discussion mature form of galactose binding protein a soluble periplasmic protein We have previously used the sami Materials and Methods precursor of galactose binding protein We show that for all ligands tested the patterns of contact are the Ee ea eferences Supporting Information Even though there are no specific sequences that mediate interaction with SecB the binding to physiologic ligands is ch 2 constants in the range of 5 nf to 30 n4415 This high affinity coupled with low specificity has been attributed to the existe interaction Studies with short peptide ligands19 showed that the SecB tetramer binds one peptide per monomer with mi lang polypeptide ligand is bound to a tetramer with nanomolar affinity The interaction of SecB with long stretches of poly 19 Randall LL 1992 Peptide binding by chaperone SecB implications for recognition of nonnative structure Science 257 241 245 CrossRef PubMed ChemPort 8 displays the interactive surface on SecB with the residues colored to indicate the nature of the side chain that was sub 3 Figure 3 Examples of discrepancies between N or C cap positions assigned by a Q yi TE i L Figure 3 Examples of discrepancies between N or C cap positions assigned by Pattern 1 N cap of a helix
15. 3 function returns to the E 5 6 Advanced Search page SelectAll Save to profile Export Citation FILTER LIST PUBLICATION TYPE keeping search terms and Journals 2 4 options you have made VIEW 1 20 24 40 41 60 64 75 C Measurement of complexed PSA inthe differential 3 Save sea rch to your pro cancer and benign prostate hyperplasia f THE PROSTATE file only available to reg Volume 42 Issue 3 15 February 2000 Pages 191 185 Xavier Filella Juan Alcover istered users Rafael Molina Juan Manuel Corral Pablo Carretero and Antonio Manuel Ballesta Article first published online 18 JAN 2000 12 00AM EST DOI 10 4002811 O97 0045 2000021 9942 34181 AID PROSS 3 0 C0 2 M Abstract PDF 183K References Future releases will in 7 clude options to filter E Population based prostate specific antigen testing in the UK leads to a stage migration of prostate cancer by year access rights BJU INTERNATIONAL and su bject Volume 104 Issue 11 December 2009 Pages 1592 15496 Alison L Moore Palyseni Dimitropoulou Athene Lane Fhilip H Powell David Greenberg Clement H Brown Jenny L Donovan Freddie Hamdy Richard M Martin and David E Meal Select one or more results Article first published online 22 JUN 2009 12 00AM EST DOI and 10 111174 1464 410 2009 08652 x Abstract Full Article HTML PDF 246K References 4 Filter results by product 5 Save to your profile only av
16. DOI 10 1002 97804707 76087 Advanced Saved Searches Table of Contents Reviews About this Book Author Biography Over recent years the study of addiction has moved from being a fragrnented and under developed area of science to become a forefront subject with its own identity This book More about this book summary SEARCH OTHER PRODUCTS Some of the specialized Antahansann ttle Antia Dyar recent years the study of addiction has moved from being a fragmented and under developed area of science to become a forefront subject with its own identity This book describes that fascinating process of evolution through a series of probing face to face interviews with the international scientists and other actors in the field who helped make the process happen Less about this book summary Table of contents Select All Save to My Profile Export Citation f E Frontmatter pages i viii Summary PDF 55K Part Addiction Scientists from the USA E Y Chapter 1 Vincent Dole pages 1 10 Summary PDF 68K References E Chapter 2 Charles S Lieber pages 11 28 Summary PDF 118K References O Chapter 3 John Ball pages 29 38 Summary PDF 75K References cof Chapter 4 LeClair Bissell pages 39 44 Summary PDF 57K References E Chapter 5 Avram Goldstein pages 45 58 Summary PDF 91K References E Chapter 6 Howard T Blane pages 59 71 Summary PDF 85K References 2 11
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18. P SEA c Pattern 2 C cap of a helix STRIDE f differences are shown quencies of N or C cap tral positions are in red wm et re umaa we Ae Oe e ad e hd which is available at s g 3 5 is P iow their capping positions E agions are resolved Hence amp e and two patterns 5 that is t reen SSAMs is quite easily ol e s 3 and three patterns 4 wt N N N NI Nesp NI N2 N3 N4 out C G C3 Ci Comp CI CP O OP es E alex Surprisingly even the position poston id by 1 residue These re Pattern 3 N cap of B sheet XTLSSTR Pattern 4 C cap of B sheet SECSTR iy Previous works done us N a z e a g d in cores 99 Thus at each posi i a z mative positions see Suppe Bs a cid 6 over and y under re g lt 9 P1 PE GN P AQDE IGN a and KAKSI This position p 2 oO a Ne N3 N2 Ni Neap NI N2 N3 N4 owt C4 C3 C2 Cl Ceap Cl C2 CY CS owi posi gt position tour kinds of diffe s are in red color Colc Abstract Article References 4 14 Topping TB Randall LL 1997 Chaperone SecB from Esche Biol Cher 2TA 19314 19315 References CrossRef PubMed ChemPort 15 Randall LL Topping TB Suciu O Hardy SJS 1998 Calorim 1195 1200 Direct Link Abstract PDFIIB4 K References Ss aaa a E a S a 1860 10f9 100 by ka Fina 5 Export chaperone SecB uses one surface of interaction for diverse unfolded polypeptide ligands Angela A Lilly J
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24. ation for this Chapter Additional Information Show All 4 How to Cite Publication History ISBN Information Summary Chapter References 5 summary Chapter References 6 Keywords aiis industry international travels alcohi 14 Topping TE Randall LL 1597 Chaperone SecB from Esche Summary Biol Gham 272 19314 19315 This chapter contains section titled CrossRef Fubtled ChemPort tering into druge Hearn 15 Randall LL Topping TB Suciu D Hardy SJS 1998 Calorim e Bing Spear a famous Chief Insp 4195 1200 Direct Link Abstract POF 16473 References e The Home Office index as a research te e The Hartnoll Mitcheson study e New heroin problems emerge e A developing research agenda e What place for national surveys e Britain s national drug strategy e The funding of research e References Get Chapter PDF 71K RELATED CONTENT ON WILEY ONLINE LIBRARY For more options go to Advanced Search Find other content like this one that cite this one 7 e Addiction Evolution of a Specialist Field Published Online 8 FEB 2008 12 00AM EST Summary References BBA eF oom H gre Joy Mott Joy Mott was born in 1933 in Cape Town South Africa She gained an MA in psychology from the Uni versity of Natal in 1956 She was a Research Officer Home Office Research Unit now Research Devel opment and Statistics Directorate London 1962 65 and Principal Research Officer from 1966 94
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