DRUG DISCRIMINATION - Med Associates Inc.
Contents
1. Correct Lever Left 1 Right 2 Reward Pellet 1 2 Drug 3 1 000 Reward Time sec 0 050 Time Out Following Reward 0 000 Refresh Session Time Min 60 000 Fixed Ratio Value 1 000 Maximum Reinforcers 50 000 Close SoftCR Data Array 1 No 0 1 000 Help Display Data Additional Boxes to Update 1 Select All Deselect All 13 MED ASSOCIATES INC DRUG DISCRIMINATION Macros The simplest way to initially create a macro is to record keyboard functions while performing the steps manually Once the commands are in the macro it is easy to create a number of macros with the macro editor The following example illustrates the process of loading Box 1 and changing the Time Out Following Reward to 10 seconds To begin open MED PC and going directly to the run time screen Close the load wizard if present Before loading or opening the procedure click Macro on the main menu and select Turn On Macro Recorder or click the 8th tool bar item with the cassette tape icon on top A note on the bottom of the display indicates that the recorder is running Open DD Food Shaping mpc by clicking Files Open Session Change the variables using any of the methods described above When all settings have been made turn the recorder off again by using the main menu or tool bar Save the macro with a distinctive name The example in Figure 3 14 was2. SABNAABARBABNAARARRR AR ARAM MR RERMRAM MNA MM KERENKANARNRMAREAKE 21 Understanding the Data Files eedem ate aed dese ra eU LR ae ER 21 DD Food Shaping mpc Sample Data 21 DD Training mpc and DD Testing mpc Sample Data 24 Chapter 6 asia 229232483583 0 aROARARARARARAR NARARAN MARMRARIRENLNLSIREANERNAANARAREAKR 27 Usindg SOTECR M PrO never a Ru oa ened e CE GRUT ur OE d Ka o aa ees 27 Senior 27 Control Code EE ed eee nts dace ee eed 27 Data Element Format ha UE Y taka RR a red uua d tenes 27 Example 0f SOTECR DEN DEI OD TER 29 MED ASSOCIATES INC DRUG DISCRIMINATION CHAPTER 1 Introduction The purpose of this manual is to give an explanation of the MED State Notation Procedures that comprise the SOF 700RA 24 Drug Discrimination Procedures The files in this package can be found on the disk provided by MED Associates Inc These procedures are intended to be run in MED Associates MED PC software The latest version of MED PC gives researchers the ability to use pre programmed procedures such as these to make hardware control and data collection easy These pre programmed procedures can also be modified to meet the evolving demands of a research protocol Again it is the intent of
3. Outputs LeftLeverOp RightLeverOp Pellet Dipper LeftLight RightLight HouseLight Pump oO x A Ui 4 CO C0 If both Pellet and Dipper are ordered It will be necessary to change one of these A Control Variables with Assigned Aliases as Defined Var Alias Correct Lever Left 1 Right 2 Var Alias Reward Pellet 1 Dipper 2 Drug 3 Var Alias Reward Time sec Var Alias Time Out Following Reward sec Var Alias Session Time min Var Alias Fixed Ratio Value Var Alias Maximum Rewards Var Alias SoftCR Data Array Yes 1 No 0 A 0 CorrectLev Reward RewardTime TimeOut SessionTime FRVal MaxRewards SoftCR RewTimeTicks TimeOutTicks AIODUPWNHE Oo Default Default Default Default Default Default Default Default Program ends when Maximum Rewards are earned or when the Session Time ends Left Lever Pellet 0 05 seconds 0 seconds 60 minutes 1 50 Yes List Data Variables Here NV B Summary Data Array B 0 Total Responses B 1 Total Correct Response Count B 2 Total Incorrect Response Count B 3 Correct B 4 Incorrect Constants for Summary Data Array B Total 0 CorrectResp IncorrectResp Correct Incorrect TotalRewards uon dw og Ot 0 N H NV C IRT Array and Event Pen Code for Soft Cum Recorder u ct Working Variables Here Subscript for the IRT Array C Ratio C
4. 0 A SessionTime 60 A FRVal 1 SET A MaxRewards 50 A SoftCR 1 gt 82 MED ASSOCIATES DRUG DISCRIMINATION 52 First Statement Wait for START signal turn HouseLight ON test for Correct Lever and turn associated stimulus ON Second Statement Update screen display with default values for Control Variables This will show any changes made via the Configure Change Variables Window prior to START START CLEAR 1 60 SET A RewTimeTicks Pad ub A RewardTime 1 SET A TimeOutTicks A TimeOut 1 ON LeftLight RightLight HouseLight ON LeftLeverOp RightLeverOp gt 53 1 SHOW 1 Lever Code A CorrectLev 2 Reward A Reward 3 Reward Time A RewardTime SHOW 4 Time Out A TimeOut 5 Session Time A SessionTime 6 FR Value A FRVal SHOW 7 Max Rewards A MaxRewards 8 SoftCR A SoftCR SX 53 Test for Correct Lever SRA CorrectLev ADD L B Total B CorrectResp Z Z Correct IF L gt A FRVal GFR Value Met False GFR Met ADD B TotalRewards SET L 0 ZA Reward 272 Reward gt S4 False gt SX R LeftLever ADD B Total B IncorrectResp 272 Incorrect gt SX R RightLever ADD B Total B IncorrectResp Z Z Incorrect SX 2 2 End gt S10 54 Time Out Interval Following Reward A TimeOutTicks 4T IF B TotalRewards gt A MaxRewards End Cont End 272 End gt S10 GCont S3 2 2 End gt
5. RIGHT LEVER RIGHT LEVER PELLET DIPPER ees LEFT LIGHT 4 ess 5 ees 6 ees HOUSE LIGHT 7 eee 7 PUMP 28 Volts A gt DD Food Shaping mpc This program mimics a Fixed Ratio schedule The program starts by turning on the house light and both the left and right stimulus lights trial consists of correctly responding on a lever to receive a reward which is followed by a time out The program ends when the maximum number of rewards are earned or when the session time ends whichever comes first Total responses total correct responses total incorrect responses percent correct responses percent incorrect responses and total rewards are collected By default SoftCR Pro data will also be collected Variable Name Value Correct Lever Left 1 Right 2 1 Reward Pellet 1 Dipper 2 Drug 3 1 Reward Time seconds 0 05 Time Out Following Reward seconds 0 Session Time minutes 60 Fixed Ratio Value 1 Maximum Rewards 50 SoftCR Data Array Yes 1 No 0 1 DD Training mpc This program begins with an Acclimation Time Following the Acclimation time the program turns on the house light and both the left and right stimulus lights Responses on the correct lever result in a reward and turn off all lights This is followed by an inter trial interval Responses on the incorrect lever will reset the current fixed ratio T
6. 12 19 Source Code 0 000 Group End Date Comments Box Time 14 09 55 End Time od Shaping 0 00 00 00 0 00 01 15 0 00 02 30 0 00 03 45 0 00 05 00 aL E L4 m P aa d id LLL 1 1 a a Ready NUM 29
7. Reward 1 A RewardTime SET A TimeOut HB a SessionTime 60 A FRVal SET A MaxRewards 50 A SoftCR 1 52 Change A TimeOut 0 to A TimeOut 10 and save the changes with the same or a new file name such as DDFoodShaping Time Out 105 Remember if creating a new mpc file name and are using a macro to load boxes the file name in the macro also must be changed Translate and compile the new or changed file as described previously and run MED PC IV Use the Change Variables screen to view confirm the new values m uo 1 4 Understanding the MED State Notation Application I ntroduction See the MED PC User s Manual for details regarding the processing of commands in MED PC The MED PC Programmer s Manual and online tutorial provides necessary information on Med State Notation and these resources will be very helpful when making adjustments to an existing mpc program or creating a custom mpc program A copy of the DD Food Shaping file follows for reference purposes and State Sets S S in the notation are briefly described State Sets 20 23 and 32 are the same in each program DD Food Shaping mpc Copyright C 2008 MED Associates All rights reserved Drug Discrimination Food Shaping mpc Responses on the Correct Lever will give a Reward followed by a Time Out Totals are collected and so is SoftCR Inputs LeftLever Right Lever
8. State Set 20 counts the time used for recording SoftCR data with a resolution of 10 milliseconds A A E e e a e A A E E E e e AR I kk kk kk k Ck Ck ko k ck Ck IR k k k k kk k k k N INCREMENT TIME T FOR IRT AND EVENT ARRAY FOCI IC II III ICICI III ICICI I III I I a A ER Re 5 5 20 51 START A SoftCR gt 0 gt 52 52 0 01 ADD T gt SX 272 End gt S1 Description of State Set 21 State Set 21 records a Step in SoftCR for every correct response that is made NOK kk kk A RR AR IR AK kk k k k ADD A STEP ELEMENT TO ARRAY C FOR EACH CORRECT RESPONSE kk Ck Ck kk koc k Ck ck ck ck ck kck ck Sl START IF A SoftCR gt 0 gt S2 52 2 2 Correct SET C I 0 10 0 ADD I IF I 10000 True False True gt S2 False SET C I 987 987 SX Z Z_End gt S1 Description of State Set 22 State Set 22 records a Pip in SoftCR for every reward that is issued kk k ck kk kock ck Ck Ck koh ck Ck kk ke kk kk koc ck k k k k kk k k k kk ke X ADD A PIP ELEMENT TO ARRAY C FOR EACH REWARD A E KK Ck Ck kk Sk Sk kk kk e 5 5 22 51 START A SoftCR gt 0 gt 52 52 2 2 Reward SET C I T 0 20 0 ADD I IF I 10000 True False True gt 51 False SET C I 987 987 gt SX Z Z_End gt 51 Description of State Set 23 State Set 23 records
9. 000 17 000 8 000 900 000 9 000 93 004 0 270 Array C Array C contains summary information for SoftCR Pro The value of every variable conforms to the Data Element Format described Please refer to the SoftCR Pro User s Manual for more information If the fixed ratio is left at 20 default value then reinforcement takes place after 20 responses on the correct lever occur Response time values are represented in SoftCR ticks To calculate when a response has occurred in real time multiply the number by 0 01 sec since SoftCR Pro s resolution is 10ms 0 01 sec For example value in C 1 is 387 ticks 387 multiplied by 0 01 sec yields 3 87 seconds This is when the first response has occurred in real time after the program has started Only a portion of Array C is shown below c 0 C 1 2 C 3 c 4 C 5 c 6 C 7 C 8 Row SoftCR is Incorrect Set Event Incorrect Set Event Correct Correct Correct Correct Activated Response Pento Response Pen to Response Response Response Response Marker Level 0 Level 0 0 0 500 387 600 0 500 128 600 0 500 177 100 97 100 205 100 145 100 9 10 C 11 C 12 C 13 C 14 C 15 C 16 C 17 Correct Correct Correct Correct Incorrect set Event Incorrect set Event Incorrect Response Response Response Response Response Pento Response Pen to Response Level 0 113 100 68 100 128 600 0 500 51 600 81 600 19 21 22 23 24 26 Correct Correct Correct Correct Correct Correct
10. Procedure DD FOOD SHAPING Subject Subject 1 Experiment Experiment 1 Group Group 1 Comment Food Shaping Experiment Filename FoodShaping Subject Groupl Click Next to finish loading the box or Previous to correct errors MED ASSOCIATES INC DRUG DISCRIMINATION The Alter Session Parameters Screen shown in Figure 3 7 is the next screen to appear and is an important screen for the researcher The Alter Session Parameters screen allows the researcher to alter the parameters by which a procedure executes The Send Start Command Screen appears next The options available on the screen vary depending upon how many boxes are described in the Hardware Configuration Figure 3 7 Alter Session Parameters Screen Correct Lever 1 Right 2 Reward 1 Dipper 2 Drug 3 Reward Time ses Time Out Following RE Session Time il Fixed Ratio Mis Maximum Rainforests SoftCR Date Array Yes 1 No 0 In this example only one box is described in the Hardware Configuration so Figure 3 8 will appear next If more than one box is in the Hardware Configuration then Figure 3 9 will appear Figure 3 8 Send Start Command Screen for Single Box Configuration 10 lt MED ASSOCIATES INC DRUG DISCRIMINATION Figure 3 9 Send Start Command Screen for Multiple Box Configuration In both cases Figure 3 8 and Figure 3 9 the screens are where the researcher decides to e
11. S10 S10 End of Session Turn Lights Off Calculate Correct and Incorrect 0 01 OFF HouseLight LeftLight RightLight IF B Total 0 NoCalc Calculate NoCalc SHOW 6 Correct B Correct 7 Incorrect B Incorrect gt S11 Calculate SET B Correct B CorrectResp B Total 100 SET B Incorrect B IncorrectResp B Total 100 SHOW 6 Correct B Correct 7 Incorrect B Incorrect S11 511 Holding State at End of Session i s gt SX Description of State Set 2 State Set 2 waits for a reward to be given and then times how long that reward is given for k Ck kk kock Ck Ck e e kk I kk kk Ck koh ck kk A IO k k ke kk N REWARD CONTROL TIMER NOKCKCKCKCKOKCKCK CK Ck Ck kk kk oko CC kk k kk I 5 6 2 S1 2 2 Pellet ON Pellet gt S2 272 Dipper ON Dipper gt 52 272 Pump ON Pump 82 52 Time Reward Device for A RewardTime seconds Default value set in S S 1 S1 amp S2 A RewTimeTicks fT OFF Pellet Dipper Pump gt S1 IIR IRR I RO UPDATE DISPLAY A E RRA AAA ko ko ko ke ko ko ke Ck k k Ck kk ke ke e k 5 6 3 91 START SHOW 2 Tot Cor Rsp B CorrectResp 3 Tot Incor Rsp B IncorrectResp 4 Reward B TotalRewards gt S2 52 TT SHOW 27 Tot Rsp B CorrectResp 3 Tot Incor Rsp B IncorrectResp 4 Reward B TotalRewards gt S2 Description of State Set 20
12. Used N 0 000 Not Used O 0 000 Not Used P 0 000 Not Used Qu 0 000 Not Used R 0 000 Not Used 5 139 000 Elapsed Time in Session T 0 000 Not Used U 0 000 Not Used V 0 000 Not Used W 0 000 Not Used 0 000 Not Used Y 0 000 Not Used 2 0 000 Not Used Array contains the control variable values The values are preset to default values in State Set 1 State 1 They are displayed as named variables and can be changed by any of the methods described previously Once a session is started these values should not be changed to ensure the integrity of the experiment A 0 1 2 3 A 4 5 6 7 8 9 Reward Time Time Out Fixed Correct Reward Reward Following Session Ratio Maximum Time in Out in SoftCR ow Lever Time Reward Time Value Rewards MED MED Marker Ticks Ticks 0 1 000 1 000 0 050 0 000 60 000 1 000 50 000 5 000 0 000 L000 Array B The B Array contains trial data B 0 B 1 B 2 B 3 B 4 B 5 Total Total Total Correct Incorrect Total Responses Corrent tes Responses Responses Rewards Row Marker Responses Responses 0 64 000 50 000 14 000 78 125 21 875 50 000 Array C contains summary information for SoftCR Pro conforms to the Data Element Format described Please refer to the SoftCR Pro User s Manual for more information If the fixed ratio is left at 1 default value then reinforcement takes place every time a response on th
13. a spike in SoftCR in the event pen line 0 for every incorrect response kk kk ck kk koh ck kk AR E e e e I e E k k e e k a k k k k k k k k ck ck ck k k ck ck IO k k k ADD AN EVENT ELEMENT TO ARRAY C FOR EACH INCORRECT RESPONSE RR AE A A E E HE kk e e e kk kk E AE k k k k k k 5 9 93 S1 START IF A SoftCR gt 0 True False True SET C I 0 50 I I 1 C I 987 987 gt S2 False gt 51 52 272 Incorrect SET C I 0 60 1 1 0 50 0 I 2 IF I 10000 GTrue GFalse True gt S1 False SET C I 987 987 gt SX 272 End S1 Description of State Set 32 State Set 32 counts the total session time and ends the program when the maximum time allowed has been reached NOKCKCK kk A A E kk kk k koc AOR kk k kk k K k kk kk kk kk kk k k k kk k k k k N SESSION CLOCK NCKCKCKCKCKCKCkCKCKCkCk Kk Kk A k k k k k k 829 325 81 START SHOW 1 Session S 60 S2 S2 1 ADD S SHOW 1 Session S 60 IF S 60 gt A SessionTime EndSession ContinueTiming End 2727 End gt S3 GCont gt SX 2 2 End gt S3 53 Wait for Screen Update and end with STOPABORTFLUSH for Automatic Data Saving A RewTimeTicks T STOPABORTFLUSH 5 Understanding the Data Files Data can be saved manually by selecting FILE SAVE DATA MANUALLY or FILE SAVE DATA FLUSH The file name that is used to s
14. named DDFoodShaping TimeOut_10sec mac since the Time Out Following Reward was changed to 10 seconds Figure 3 14 DDFoodShaping TimeOut 10sec mac DDFoodShaping TimeOut 10sec MAC Notepad File Edit Format View Help LOAD BOX 1 SUBJ 0 EXPT 0 GROUP 0 PROGRAM DD FOOD SHAPING SET Time out Following Reward sec VALUE 10 MAINBOX 1 BOXES 1 Once this macro is built use the macro editor to make simple changes such as replacing reward or correct lever values Review the Help file on screen or the MED PC User s Manual for more information on macros and the features offered A START command or message box followed by a START command could be added to the macro it was left off here so changes could be verified before starting the procedure MED ASSOCIATES DRUG DISCRIMINATION Modifying the MedState Notation Code Permanent changes to the Drug Discrimination procedures can be made to the MedState Notation code To make the same change to the Time Out Following Reward as shown above do the following Open Trans IV and select File Open to place DD Food Shaping mpc into the text editor Scroll down to approximately line 102 note the line counter in the lower right hand corner of the editor to reveal the code shown in Figure 3 15 Figure 3 15 DD Food Shaping mpc Line 102 EX TRANS IV C MED PC IV MPC DD Food Shaping mpc ES File Edit Search Options Translation Window Help Si 0 001 SET A CorrectLev 1 A
15. of the selected boxes Figure 3 11 Changing Variables Screen Displaying Variables from Box 1 Array B Array C Array aon T x Named Yars E G H 4 Yars 0 000 0 000 0 000 0 000 0 000 M N 23 0 000 0 000 0 000 0 000 0 000 Refresh Q R 5 T 0 000 0 000 0 000 0 000 0 000 Issue U y W X E 0 000 0 000 0 000 0 000 0 000 Close 0 000 Display Data from Box Additional Boxes to Update D from Box 1 LN 0 000 x Select All Deselect All The value of any simple variable may be viewed from this screen by clicking an array on the table and each element in that array can be viewed as shown in Figure 3 12 To change a value simply highlight and replace the value in the lower right hand box or use the up down arrows to increment by 1 Click the Issue button for the change to take effect Click Named Variables to produce the display in Figure 3 13 Change variables here as needed E s MED ASSOCIATES INC DRUG DISCRIMINATION Figure 3 12 Displaying Array A from Box 1 Displaying Array from Box 1 A 2 A 3 4 Named Vars 1 000 0 050 0 000 60 000 A 6 419 A 3 Mars 50 000 0 000 0 000 1000 Refresh Issue Additional Boxes to Update 0 from Box 1 Se Select All Deselect Al 1 000 Figure 3 13 Displaying Named Variables from Box 1 Displaying Named Variables from Box 1
16. to run the procedures included in this package Should there be any problems the staff at MED Associates Inc is available to answer any questions that may arise Please e mail us at support med associates com with a detailed description of the problem or desired goals so that concise and detailed information may be provided The Drug Discrimination procedures are designed to be as easy to use as possible MED Associates Inc understands that researchers do not have the time to devote to programming and hardware design and for that reason we have undertaken that burden for you We sincerely hope that you are satisfied with the products and services we provide and look forward to meeting your future experimental needs as your research program evolves MED ASSOCIATES INC DRUG DISCRIMINATION Overview of the Procedures The Drug Discrimination programs were written for MED PC IV There are three different programs included on the Drug Discrimination CD DD Food Shaping mpc DD Training mpc and DD Testing mpc Inputs and Outputs The MED Interface Panel should be wired as follows when using the Drug Discrimination procedures These connections can be different but the procedures must be changed accordingly If both a Pellet Feed and Dipper are being used concurrently the output configuration must be changed in the procedure Figure 1 1 Interface Panel Connections Labeled S6 716 e OUTPUTS INPUTS LEFT LEVER LEFT LEVER
17. Correct Correct Correct Response Response Response Response Response Response Response Response Response 0 500 47 100 34 100 37 100 21 100 19 100 18 100 16 100 17 100 Array D Array D contains trial by trial data 00 00 1 00 2 D 3 D 4 00 5 00 6 D 7 D 8 Trial Total Correct Incorrect Response ME Number Responses Responses Responses Repente Rate PEN Ratio 0 1 000 33 000 28 000 5 000 1 000 46 930 84 848 0 703 20 000 9 2 000 20 000 20 000 0 000 0000 35 200 100 000 0 568 20 000 18 3 000 28 000 25 000 3 000 1 000 25 460 89 286 1 100 20 000 27 4 000 20 000 20 000 0 000 0 000 24 190 100 000 0 827 20 000 35 5 000 41 000 35 000 6 000 2 000 31 180 85 366 14345 20 000 45 6 000 29 000 28 000 1 000 1 000 64 090 96 552 0 452 20 000 54 7 000 20 000 20 000 0 000 0 000 32 660 100 000 0 612 20 000 63 8 000 39 000 37 000 2 000 2 000 331 190 94 872 0 118 20 000 82 9 000 13 000 13 000 0 000 0 000 9 100 100 000 1 429 20 000 6 Using SoftCR Pro The Fixed Ratio procedure stores IRT data in array C that may be used by the SoftCR Pro Cumulative Recorder program to generate a graphical record on screen or to print a Cumulative Record after the data has been collected Each element in this Cumulative Record data array consists of two components The integer value or value to the left of the decimal point is the time component The decimal value or value to the right of the decimal point is a SoftCR Pro cod
18. DRUG DI SCRI MI NATI ON MED PC IV APPLICATION SOF 700RA 24 Manual DOC 186 Rev 1 1 Copyright O 2009 All Rights Reserved MED Associates Inc P O Box 319 St Albans Vermont 05478 www med associates com MED ASSOCIATES INC DRUG DISCRIMINATION TABLE OF CONTENTS Chapter 1 t 1 1 Overview of the nenne 2 parle 5 Getting Ezio CD Emm 5 Software I nstallatlon ur ere eter tee ro kennen Ee ey LE RE RR ee E ER RE 5 Backing Up the nenne 5 Chapter e 6 Beginning amp Running an Experiment ssssssssse eene 6 Translating the MED PC mpc File 6 Using the MED PC Coad Wizard uoi ert rnit tk tw tete o t ett 7 Viewing Changing Variable Values sss mmm 12 urere IMEEM 14 Modifying the MedState Notation Code ssssssseeee e 15 Chapter 4 STPPP LL LL LL I 16 Understanding the MED State Notation 16 Wrideeref leubpbeeee e E 16 DD Food SHAPING MPG aerisire soe t adds d bug Pata te Da Pret dana A Au 16 Chapter 5 2
19. Used G 0 000 Not Used H 0 000 Not Used T 269 000 Subscript for the IRT Array C J 72 000 Subscript for the Trial by Trial Array D K 0 000 Not Used L 13 000 Ratio Count M 0 000 Not Used N 0 000 Not Used O 0 000 Not Used 0 000 Not Used Q 0 000 Not Used R 0 000 Not Used S 9 100 Trial Time Counter T 66 000 Elapsed Time in 0 01 sec Increments for SoftCR Data U 0 000 Not Used V 0 000 Not Used W 0 000 Not Used X 0 000 Not Used Y 0 000 Not Used 2 0 000 Not Used Array A Array A contains the control variable values The values are preset to default values in State Set 1 State 1 They are displayed as named variables and can be changed by any of the methods described previously Once a session is started these values should not be changed to ensure the integrity of the experiment A O 1 A 2 4 A 5 6 A 7 A 8 A 9 A 10 A 11 Correct Acclim ITI FR Value Max Session Reward Reward SoftCR Acclim Time ITI Time in Time in Lever Time Time Rewards Time Time in MED Ticks MED Ticks MED Ticks 1 000 5 000 20 000 20 000 20 000 15 000 1 000 0 050 1 000 30000 000 2000 000 5 000 The B Array contains trial data 0 B 1 B 2 B 3 B 4 B 5 B 6 B 7 0 iwi Total Total Total Total Total Total Correct Total 0 Correct Incorrect d Session ial Responses Response Marker Responses Rewards Trials Responses Responses Time Rate 0 243 000 226
20. ave the data in depends on the option that was chosen in the Hardware Configuration Utility and may also be dependent on the Subject Experiment and Group name provided in the MED PC load wizard Within each data file the headings are created for each Subject Experiment Group Box etc see below Data files may be opened with note pad word pad or any word processor or spreadsheet however be sure they are always saved unformatted in case a data extraction utility such as MED PC to Excel might ever be used Data file formats are explained in detail in the MED PC User s Manual DD Food Shaping mpc Sample Data File Select Annotated on the file options page during hardware installation to produce a raw data file similar to the following Data files may be opened with note pad word pad or any word processor however be sure they are always saved unformatted in the occasion a data extraction utility such as MPC2XL is used The header information should be self explanatory Data file formats are explained in detail in the MED PC User s Manual File C MMED PC IVNDATAN 2007 10 02 Start Date 10 02 07 End Date 10 02 07 Subject 0 Experiment 0 Group 0 Box 1 Start Time 14 09 55 End Time 14 12 19 MSN DD Food Shaping D 0 000 Not Used E 0 000 Not Used 0 000 Not Used G 0 000 Not Used H 0 000 Not Used 129 000 Subscript for the IRT Array C J 0 000 Not Used K 0 000 Not Used L 0 000 Ratio Count M 0 000 Not
21. e component Refer to the SoftCR Pro User s Manual for further information Time Components Time components may be Relative or Absolute Ina Relative file the time component of a given data element is equal to the elapsed time since the previous element an Absolute file it is equal to the elapsed time since the beginning of the Record The elements used in Fixed Ratio are all Relative with a resolution of 0 01 seconds 10 milliseconds Control Code Components The control code component indicates whether the element is a Response Step Reinforcement Pip Pen Reset Event Pen Up or Event Pen Down element Up to 10 Event Pens 0 9 and 10 Trace Pens 0 9 may be specified in MED PC In addition Resets may be made with the Pen Up no vertical tracing or Down Additional coded information may be possible in the future Data Element Format Each data element must conform to the following format nnnnn Xyz Where nnnnn Time Component Xyz Control Code Component x Datum Type y Datum Index z lt Don t Care Digit NOTE there are more than three numbers past the decimal point then the array will be considered invalid and will be ignored by SoftCR Pro Allowed datum types and indices are nnnnn lyz nnnnn 2yz nnnnn 3yz nnnnn 4yz nnnnn 5yz nnnnn 6yz nnnnn 7yz nnnnn 8yz nnnnn 9yz Response or Step y Index 0 9 for Multi Trace Files NULL for Single Trace Files Reward or P
22. e correct lever occurs Response time values are represented in SoftCR ticks To calculate when a response has occurred in real time multiply the number by 0 01 sec since SoftCR Pro s resolution is 10ms 0 01 sec For example value in C 1 is 231 ticks 231 multiplied by 0 01 sec yields 2 31 seconds This is when the first response has occurred in real time after the program has started Only a portion of Array C is shown below 0 SoftCR is Activated 0 500 C 5 Correct Response 42 100 C 10 Set Event Pen to Level 0 0 500 C 1 Correct Response 231 100 C 6 Reward 0 200 C 11 Incorrect Response 33 600 2 C 3 Correct Reward Response 0 200 7 Set Event to Level 0 0 500 Incorrect Response 40 600 C 12 C 13 Set Event Pen to Level 0 0 500 Correct Response 31 100 The value of every variable 4 0 200 9 Incorrect Response 27 600 C 14 Reward 0 200 Ore DD Training mpc and DD Testing mpc Sample Data File The data files generated by the DD Training mpc and DD Testing mpc procedures will appear the same and therefore just one example is shown below File C MED PC IV DATA 2007 10 02 Start Date 10 02 07 End Date 10 02 07 Subject 0 Experiment 0 Group 0 Box 1 Start Time 14 15 01 End Time 14 30 12 MSN DD Training 0 000 Not Used 0 000 Not
23. he MED PC User s Manual for a complete guide to installing the MED PC software building a valid Hardware configuration with the Hardware Configuration utility and opening and compiling a MSN procedure in the Trans IV utility To install the Drug Discrimination Procedures insert the CD into the CD ROM drive and click Install the Drug Discrimination Software The procedures are copied into the indicated folder Backing Up the Software Med Associates strongly encourages creating backup copies of the programs in case of disk failure Having copies of the original programs may be useful in the future should modifications be made to the existing programs MED ASSOCIATES INC DRUG DISCRIMINATION CHAPTER 3 Beginning amp Running an Experiment Translating the MED PC mpc File Programs written in MedState Notation must be translated using Trans IV before they can be executed in this application Open Trans IV icon and select Translation Translate and Compile Select the program s to use for the experiment and click Make Click OK to start the translator and it will automatically parse the MedState Notation and then open to a DOS screen to compile the Pascal code Depending on the speed of the computer each of these steps may not be seen If any problems are encountered during this process refer to the on screen help menu or the MED PC Version User s Manual or contact MED Associates Inc for assistance Figure 3 1 Trans IV Con
24. he program ends when maximum number of rewards are earned or when the session time ends Totals for the whole program are collected as well as the data for each trial By default SoftCR Pro data will also be collected Variable Name Default Value Correct Lever Left 1 Right 2 1 Acclimation Time minutes 5 ITI Time seconds 20 Fixed Ratio Value 20 Maximum Rewards 20 Reward Pellet 1 Dipper 2 Drug 3 1 Reward Time seconds 0 05 SoftCR Data Array Yes 1 No 0 1 DD This program starts with an Acclimation Time Following the Acclimation time the program turns on the house light and both the left and right stimulus lights Responses on either lever will result in a reward and turn off all lights This is followed by an inter trial interval The program ends when maximum number of rewards are earned or when the session time ends Totals for the whole program are collected as well as all data during each trial are collected SoftCR is also recorded Variable Name Value Correct Lever Left 1 Right 2 1 Acclimation Time minutes 5 ITI Time seconds 20 Fixed Ratio Value 20 Maximum Rewards 20 Session Time minutes 15 Reward Pellet 1 Dipper 2 Drug 3 1 Reward Time seconds 0 05 SoftCR Data Array Yes 1 No 0 1 2 Getting Started Software Installation Please refer to t
25. ip y Index 0 9 for Multi Trace Files NULL for Single Trace Files Unused Unused Set Event Pen To Level 0 Down or at baseline where y lt Event Pen Number 0 9 Incorrect Response or Set Event Pen To Level 1 Up where y Event Pen Number 0 9 Unused Unused Unused Data in the array being plotted that does not conform to the above rules will be ignored MED ASSOCIATES DRUG DISCRIMINATION Example of SoftCR Pro Figure 6 1 is an example of what Fixed Ratio will look like in SoftCR Pro after an experiment is run The red line records a Step for every correct response that is made Since this is a Fixed Ratio of 1 schedule the subject was reinforced after one response on the Left Lever A reward is recorded as a Pip or a hash mark on the red line The colored traces at the bottom of the screen are called Event Pens and can be used in a variety of ways for a number of purposes The Event Pens can go up and down creating quick spikes like the ones seen here or long plateaus that represent certain periods of time during an experiment Here the Event 0 records a Spike for every incorrect response that is made Figure 6 1 Example of a DD Food Shaping Schedule Shown in SoftCR Pro gd T Pro 2009 01 23 dat fel 2 Preferences Plot View Window Help Du lt P stan 0207 12 19 x Experiment Start Date 02 07 C MED PC IMDATAV2007 10 02 Subject t0 Start Time
26. ither load more boxes send a start signal to boxes that are already loaded or enter the MED PC run time environment without sending a start signal by selecting I am finished with the wizard This option results in the screen shown in Figure 3 10 Figure 3 10 The MED PC Run Time Screen MED PC IV File Configure View Macros Help 41 amp epi 3 el Box Subject Experiment Group Load Program 1 Subject 1 Experi 16 1 11 55 DD Food Shapit 5 LeverCode 1 00 Reward 1 00 Reward Time 0 05 Time Out 0 00 Session Time 60 00 SHOW S 6_ FR Value 1 00 Max Reinforcers 50 00 SoftCR 1 00 SHOWS 11_15 SHOWS 16 20 SHOWS 21 25 1 23 2008 11 55 05 AM Eile for LoadingBoxes open Session cuo ta es MED ASSOCIATES INC DRUG DISCRIMINATION Viewing Changing Variable Values Before a start command has been issued any variable may be changed on the MED PC run time screen Simply highlight the value to change and then enter the new value Once a session is in progress change variables by selecting Configure Change Variables or click the 4th tool bar item AX In the lower left hand corner of the Change Variables window find the Display Data from Box display and choose the chamber s to modify By clicking additional boxes in the Additional Boxes to Update section changes made to a single box are automatically loaded to all
27. ount Elapsed Time in Session ge amt um uet ll DIMA DIM B DIM ll 10000 Z Pulses Used in this Program Pellet 1 Signal Pellet Reward Z Dipper 2 Signal Dipper Reward Z_Pump 3 Signal Pump Reward Z_Correct 4 Correct Response Signal Z Incorrect 5 Incorrect Response Signal Z Reward 6 Reward Issued Signal Z End 32 End of Session Signal Description of State Set 1 State Set 1 is the main body of the program The default values of the Change Variables are defined in this state set Once a Start command is issued the lights and levers turn on and the program moves to the first FR It records correct and incorrect responses and moves to a Time Out once the FR is complete and a reward has been given When the maximum number of rewards has been reached or the session time is complete whichever happens first the percent of correct and incorrect responses is calculated kk kk kk k kk IR AOR kk koe kk ke N Drug Discrimination Food Shaping Schedule 51 Set Default Values N Correct Lever 1 Left N Reward 1 Pellet N Reward Time 0 05 seconds X Time Out Following Reward 0 seconds N Session Time 60 minutes N Fixed Ratio Value 1 N Maximum Rewards 50 SoftCR Data Array 1 RRR kc kk ko ko kk Ko KC KC CC KC k k k k k ke kk ke ke e eG e S 8 1 SL 0 001 SET A CorrectLev 1 A Reward 1 A RewardTime 0 05 SET A TimeOut
28. ted Click Next to continue Figure 3 3 The Box Selection Screen The Select a Procedure screen appears next as seen in Figure 3 4 This is where the application to be run is selected The screen displays a list of all the currently compiled procedures Select the desired procedure and then click Next Figure 3 4 The Select a Procedure Screen DD FOOD SHAPING DD TESTING DD TRAINING MED ASSOCIATES INC DRUG DISCRIMINATION The Enter Experiment Data Screen should display next as shown in Figure 3 5 The purpose of this screen is to allow annotations to be added to the data file that is produced by MED PC These annotations will help identify the Subject Experiment and Experiment Group upon which data was collected Comments can be added here as well and the data file can be given a customized file name to help identify it from other data files Enter the information desired and click Next Figure 3 5 Enter Experiment Data Screen TE Experiment Experiment 1 G roup Group 1 Comments Food 5 haping Experiment Optional Custom Filename FocdShapina Subject Groupt 2 The next screen to appear is the Review Choices screen as seen in Figure 3 6 This is method of confirming that the information received from the Box Procedure Selected is correct If it is not correct select Previous and edit the data If it is correct select Next Figure 3 6 Review Choices Screen Review the data below Box 1
29. this manual to explain exactly what these procedures implement and provide guidance into how to interpret what the program code achieves in order to let the user determine how to modify them to match their research protocol demands The manual provides some examples of editing and modifying the procedure s programming code The manual also defines the elements in the raw data file produced by these procedures In addition to this manual refer to the MED PC User s Manual for the installation of the MED Associates interface drivers the MED PC Software and the Delphi Compiler Also refer to the User s Manual for instructions on developing a Hardware Configuration Data file structure file saving format and other related options are also determined by the Hardware Configuration Running the Hardware Configuration software utility that accompanies MED PC sets the Hardware Configuration Its purpose is to assign the inputs and outputs on the interface cards in the interface cabinet for each task controlled by MED PC The particular type of interface card that is supplied in the interface cabinet may vary please refer to the User s Manual provided for instructions on how to configure the type of card that is in the cabinet A valid Hardware Configuration must exist in order for MED PC to interface correctly with the MED Associates Inc hardware This means that one should take the time to create a valid Hardware Configuration before attempting
30. trol Panel for Translating and Compiling MedState Notation Code fi Specify Files to Translate DD Food Shaping mpc DD Testing mpc DD Training mpc Build No Trans Exclude wv X Cancel Help MED ASSOCIATES INC DRUG DISCRIMINATION Using the MED PC Load Wizard MED PC is designed to help the researcher run an experiment by guiding selection choices through its Experiment Loading Wizard This section will describe how to initiate the DD Food Shaping mpc application however the following steps that will also apply to all other mpc procedures Open MED PC and the MED PC Experiment Loading Wizard s Welcome screen shown in Figure 3 2 will appear Figure 3 2 The MED PC Loading Wizard Welcome Screen To avoid this load wizard deselect the checkbox labeled Run this experiment automatically when starting MED PC Close this screen by clicking the Close button Closing this screen immediately reveals the MED PC Run Time Screen shown in Figure 3 9 If the choice to continue with the Loading Wizard is made then click the Next button MED ASSOCIATES INC DRUG DISCRIMINATION The Box Selection screen will appear next as shown in Figure 3 3 From this screen the researcher chooses which boxes will be used in the experiment Select the boxes that will run the experiment by clicking in the radio button next to the box number The figure shows that the Hardware Configuration included only 1 box which was selec
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