Asia Product Collector - Manual
Contents
1. Figure 41 sen YO gt gt TA ya A y oe 7 gt Figure 42 Page 20 of 27 6 Using the Asia Automated Collector 6 1 Setup The Asia Automated Collector Products require configuration of both hardware and software This manual only considers the hardware set up Please refer to the Asia Systems and Software Manual for instruction on operation within Asia Manager 1 Atthe rear of the module connect the power supply and the RS232 communications cable to link the Automated Product Collector to an Asia Automator for operation via the Asia Pump or Asia Manager software 2 Select the appropriate rack tray and position in bed of automated collector Figure 43 shows the position of a 2ml vial tray on the Asia Automated Collector Mini where Figure 44 shows 4 racks of 10ml tubes Figure 44 2 NOTE The Asia Automated Collectors are supplied with a third party user manual Please refer to the third party user manual when setting up the Automated Collector Syrris Ltd Asia Product Collectors Manual Page 21 of 27 Chapter Using the Asia Automated Collector 6 1 1 Connecting the BPR In order to regulate pressure in the flow chemistry system the BPR back pressure regulator is used The Pressure Controller Manual explains how to operate the BPR and it is best practice to locate the BPR at the end point of the fluidic path All Asia Automated Collectors con2. 2200400 Asia Pressurized Input Store 2200520 Asia Reagent Injector with 5ml Sample Loops 2200526 Asia Chip Climate Controller 2200563 Asia Reagent Injector with no Sample Loops 2200532 Asia Pressure Controller 2200527 Asia Heater 2200531 Asia Fllex 2200533 Asia SAD 2200534 Asia Product Collector 2200536 Asia Automator and associated accessories are in conformity with the applicable requirements of the following documents Ref No Title EN ISO 12100 Safety of machinery General principles for design Risk assessment and risk reduction Safety requirements for electrical equipment for measurement control and laboratory use General requirements EN 61010 1 2010 EN 61000 6 1 Electromagnetic compatibility EMC Part 6 1 Generic standards Immunity for residential commercial and light industrial environments EN 61000 6 3 Electromagnetic compatibility EMC Part 6 3 Generic standards Emission standard for residential commercial and light industrial environments Edition date 2010 2010 2007 2007 hereby declare that the equipment named above has been designed to comply with the relevant sections of the above referenced specifications The unit complies with all applicable essential requirements of the Directives C 12 Signed by Name Mike Hawes Position CEO Done at Syrris Ltd 27 Jarman Way Royston Herts SG85HW UK On 25th September 2012 9 3 Certificate of Decontamination T
3. Japan SOHO Station 202 24 8 Yamashita cho Naka ku Yokohama Kanagawa T 045 263 8211 E info syrris co jp W www syrris co jp Syrris Scientific Pvt Ltd India 420 421 Corporate Avenue Sonawala Road Goregaon East Mumbai 400063 T 91 22 2686 4410 E info syrris com W www syrris com Syrris do Brasil Ltda Brazil Rua Dr Bacelar 231 cj 47 Vila Clementino 04026 000 Sao Paulo SP T 55 11 5083 4963 E info syrris com W www syrris com br
4. 1 is for use in manual mode or can be used for the automated collection of one flow chemistry experiment lt consists of a 3 way valve which allows solvent between samples and or reaction samples not at steady state to be diverted to waste and the reaction product to be collected When controlled from the Asia Syringe Pump or from a PC via the Automator the valve automatically switches from waste to collection allowing total walk away synthesis of one reaction and minimum collection volume In standalone mode the valve can also be toggled manually between waste and collection using the button on the top of the module The Asia Collector can accommodate three different vial sizes in its manually rotated carousel The valve assembly can also be removed and held remotely for collection of large volumes when scaling up 3 2 Automated Collector Range The Asia Automated Collector range consists of the Mini Figure 2 Regular Figure 3 and Premium Figure 4 systems They enable fully automated collection of single to multiple reactions The Asia Automated Collectors allow the solvent between samples and or reaction samples not at steady state to be diverted to waste and the reaction to be collected The 3 way valve automatically switches from waste to collection as the product arrives at the Automated Collector allowing total walk away synthesis of multiple reactions and minimum collection volumes The Asia Automated Collectors can be
5. 6 1 Mini H 267mm x W 324mm x D 292mm Maximum number 128 12 x 75mm tubes with of collections optional Rack Code 14 Maximum collection 20ml 28 x 60mm scintillation vials with optional volume Rack Code 24 3 6 2 Regular H 330mm x W 479mm x D 464mm Maximum number 240 12 x 75mm 5ml tubes with of collections optional Rack Code 29 Maximum collection volume 32ml 18 x 180mm tubes or 25ml 18 x 150mm 3 6 3 Premium H 348mm x W 503mm x D 391mm Maximum number 432 10 x 75mm 4ml tubes with of collections four Rack Code 341 Maximum collection volume 8 1 litre bottles with one Rack Code 92 3 6 4 Common Specifications Wetted materials Glass PTFE PCTFE and PFA 2 NOTE A list of parts and part numbers are found at the end of this document Syrris Ltd Asia Product Collectors Manual Chapter Overview of the Asia Product Collectors Page 12 of 27 4 Quick Start Guide 4 1 Asia Product Collector 1 Attach the valve head to the Product Collector by aligning the slit in the front of the valve head to the slit in the front of the collector rack Figure 11 Connect the power lead to the back of the power connection at the back of the valve head Figure 12 For best practice the BPR back pressure regulator needs to be as close to the product collector valve as possible Connect the BPR to the BPR holder using the push fit fitting Figure 13 and complete the BPR connectio
6. controlled by the Asia Automator and Asia Manager PC software up to hundreds of experiments Syrris Ltd Asia Product Collectors Manual Chapter Overview of the Asia Product Collectors Figure 1 Figure 2 Figure 4 Page 7 of 27 3 3 Asia Product Collector Module Overview Switch button to toggle gt valve from waste to Valve head collect PE gt Cable tidy 3 Way Valve ae Collection Vials Rack can be turned _ gt into position gt The front of the Asia Product Collector Figure 5 BPR Holder for BPR Cable tidy _ ___ __ _ gt and push fit fitting Communications Connector to Asia Automator Area for vials f different sizes The rear of the Asia Product Collector Figure 6 Syrris Ltd Asia Product Collectors Manual Page 8 of 27 Chapter Overview of the Asia Product Collectors Waste pipe ee AE HN Switch button BPR back pressure regulator l a 3 way valve Fluidic input from gt t 3 BPR a Sample collection pipe E The valve and connections of the Asia Product Collector Figure 7 3 4 Manual Product Collector Specifications Operating pressure 0 20 bar Wetted materials Glass PTFE PCTFE and PFA Aluminium stainless steel and polyurethane Outer materials sprayed white with highly chemically resistant epoxy paint Active parts Con
7. This is situated on a bracket on the product collector moving arm When connecting the BPR it is important to support underneath the product collection arm when inserting the BPR in the connector as shown in Figure 18 5 Connect the gas line from the back of the Pressure Controller to the fitting situated beside the BPR Figure 19 6 Complete the fluidic connections from the BPR to the valve and waste Figure 20 The inlet connection from the BPR is connected to the side port of the valve and the waste connected to the top port 7 Insert vials into the Automated Product Collector tray 8 Turn the system on at the power supply The robot arm will move during the initialsiation 9 The Automated Product Collector hardware is now configured and ready for use Please consult the Asia Systems and Software Manual for automated operation using Asia Manager software Syrris Ltd Asia Product Collectors Manual Chapter Quick Start Guide 2 a Figure 17 Figure 18 Figure 19 Figure 20 Page 14 of 27 5 Using the Asia Product Collector 5 1 Setup 1 Attach the valve head to the Product Collector Figure 21 by aligning the slit in the front of the valve to the slit in the front of the collector rack Figure 22 2 Connect the power cable to the power connection located at the rear of the module Figure 23 Figure 24 NOTICE The module requires a s
8. ctors Manual Page 16 of 27 Chapter Using the Asia Product Collector 5 1 2 Attaching the Collection Waste Fittings The valve switches position from Collect to Waste and vice versa when the top button is pressed see Section 5 3 The connections to the pump input and output are made via 4 28 connectors see Figure 29 See the Appendix for how to fit the 4 28 connector on tubing There are two connections to make on the valve head 1 Connect the black fitting from the BPR Figure 30 to the input at the side of the valve as shown in Figure 31 2 Connect the orange fitting to the output at the top of the valve to waste collection as shown in Figure 32 3 The fluidic connections are complete Figure 33 L Figure 29 Figure 30 Figure 31 e C Figure 32 Figure 33 NOTE if you are not using a BPR connect the inlet from the rest of the fluidic system directly to the input at the side of the valve Syrris Ltd Asia Product Collectors Manual Chapter Using the Asia Product Collector Page 17 of 27 5 2 Adjusting the Valve Location The valve can be adjusted backwards and forwards depending on the size of the vials needed for collection Figure 34 shows the valve set for the largest size of collection vials The valve can be adjusted as follows 1 Hold the Product Collector in place on the counter top and grip the valv
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10. e from above shown in Figure 35 2 Move the valve backwards or forwards to align the valve to the medium collection vials shown in Figure 36 or small collection vials shown in Figure 37 Figure 35 Figure 37 Syrris Ltd Asia Product Collectors Manual Page 18 of 27 Chapter Using the Asia Product Collector 5 3 Switching Collect Waste Modes To operate the two modes of the Product Collector Collect and Waste there is a switch on the top of the module 1 When the module is turned on the LED will light up the current choice shown in Figure 38 as Waste 2 To switch from Waste to Collect or vice versa press the valve switch button Figure 39 3 The other mode is selected as indicated by the LED Figure 40 Syrris Ltd Asia Product Collectors Manual Chapter Using the Asia Product Collector Figure 39 v Figure 40 ao J ie Woe is Page 19 of 27 5 4 Detaching the valve head The valve head can be removed from the main body of the Product Collector lt can then be held remotely for collection of large volumes when scaling up To detach the valve head 1 Pull the spring button at the base of the valve head Figure 41 to release the lock 2 While pulling the spring button slide the valve head up Figure 42 Syrris Ltd Asia Product Collectors Manual Chapter Using the Asia Product Collector a
11. efully wipe with a dry cloth taking into account the nature of the spilled liquid and the necessary safety precautions Comply with all safety and accident prevention regulations applicable to laboratory work Always connect the instruments to an earthed ac power outlet The operating voltage is indicated on the specification sticker Non observance of this provision may result in damage to the Asia module or in personal injury or damage to property This product does not comply with the ATEX directive and must not be used in explosive atmospheres Only use the labelled input bottles supplied with the system These have been pressure tested and coated If the bottles are scratched or damaged do not use The system may be pressurised up to 20 bar Always use appropriate personal protective equipment including eye protection The automated collectors can move without warning Do not obstruct the deck area when the collectors are switched on Syrris Ltd Asia Product Collectors Manual Page 5 of 27 Chapter Safety Before removing or attaching the BPR ensure the pressure controller is switched off or it is set to 0 Cleaning work and who are aware of the possible dangers involved Asia and all the associated hardware has not been designed for sterilisation or use with an autoclave A Cleaning should only be performed by personnel trained in such Maintenance Maintenance should only be attempted by qualified service personn
12. el or under guidance by Syrris The Asia system may contain hot components please allow the unit to cool before performing any maintenance operations The on off switch must be switched to OFF and the unit disconnected from both mains and any attached apparatus whenever maintenance is performed Opening any module may invalidate the warranty Returning Equipment Equipment which has been contaminated with or exposed to body fluids toxic chemicals or any other substance hazardous to health must be decontaminated before it is returned to Syrris or its distributor A decontamination certificate is included in this manual Environmental Conditions For indoor use only Temperature range 5 C to 40 C Humidity Maximum relative humidity of 80 Waste Electrical and Electronic Equipment WEEE statement Syrris is compliant with the EU directive on waste electrical and electronic equipment WEEE please refer to www syrris com for directions and information on end of life policy Syrris Ltd Asia Product Collectors Manual Page 6 of 27 Chapter Safety 3 Overview of the Asia Product Collectors There are four different Asia Product Collectors allowing convenient collection of samples into a range of vessel sizes in a manual or automated manner The Product Collectors are located at the end of the flow chemistry fluidic set up normally after the Pressure Controller 3 1 Asia Product Collector The Asia Product Collector Figure
13. his document must be completed in full and signed by the Customer a before transporting by any means a product to Syrris for repair or service and b prior to any on site service to be performed by Syrris Ltd A completed copy of this Certificate is required to be attached to the instrument part itself AND to the outside of the packing container when transporting to Syrris Ltd or Syrris Inc e Please ensure all wetted parts have been thoroughly washed with methanol ethanol Isopropyl alcohol IPA or acetone e Please ensure any glassware has been thoroughly washed with methanol ethanol Isopropyl alcohol IPA or acetone e Please ensure any items that are being sent to Syrris is suitably packaged and well protected e Please write a brief description for the reason of this these items are being sent to Syrris e Please write down what substances the item s have been in contact with most recently Sign Name Company Name Print Name Address 1 Date Address 2 Address 3 Town City Post Code Country For the quickest response for all technical enquiries please email support syrris com Syrris Group Offices Syrris Ltd Europe and Rest of World 27 Jarman Way Royston Hertfordshire SG8 5HW United Kingdom T 44 0 1763 242555 E info syrris com W www syrris com Syrris Inc North America 29 Albion Place Charlestown MA 02129 T 617 848 2997 E info syrris com W www syrris com Syrris Japan Inc
14. n S NOTICE Never leave reagent solution in the 3 way valve after an experiment 7 1 2 Cleaning external surfaces Any spillage on the external surfaces of the Asia Product Collectors need to be quickly cleaned using a damp cloth water or isopropanol may be used Syrris Ltd Asia Product Collectors Manual Page 23 of 27 Chapter Maintenance 8 Support No third persons are authorized to repair or make any changes to the machine The device warranty becomes void if any modification is carried out without Syrris consent Only personnel trained by Syrris may carry out modifications repairs or maintenance work For any queries regarding the Asia Reagent Injector please contact support syrris com 9 Appendix 9 1 List of parts The following is a list of Syrris parts spares and consumables for the Asia Product Collector Asia Product Collector 2200534 Asia Automated Collector Mini 2200535 Asia Automated Collector Regular 2200561 Asia Automated Collector Premium 2200562 Syrris Ltd Asia Product Collectors Manual Page 24 of 27 Chapter Support 9 2 EC Declaration of Conformity We of Syrris Ltd 27 Jarman Way Royston Herts SG8 5HW in accordance with the following Directive s 2004 108 EC The Electromagnetic Compatibility Directive 2006 42 EC The Machinery Directive hereby declare that Equipment Asia flow chemistry system consisting of Part Number Description 2200292 Asia Pump
15. ns Connect the gas line from the back of the Pressure Controller to the rear of the BPR Complete the fluidic connections from the BPR to the valve and waste Figure 14 using suitable pipes Supplied in the case of an Asia System The inlet connection from the BPR is connected to the side port of the valve and the waste connected to the top port Insert vials into the Product Collector and move the valve head backwards or forwards to collect from the correct vial size Figure 15 and turn the rack to ensure that the valve will collect into a vial Turn the Product Collector on at the power supply and press the appropriate button at the top of the valve head to select either Collect or Waste Figure 16 Turn the carousel in a clockwise manner to collect into consecutive vials Syrris Ltd Asia Product Collectors Manual Chapter Quick Start Guide Figure 11 Figure 12 Figure 14 Figure 15 7 Ae Pag Figure 16 Page 13 of 27 4 2 Asia Automated Collector Range 1 Select the appropriate rack tray and position in bed of automated collector Figure 17 shows the position of a 2ml vial tray on the Asia Automated Collector Mini 2 Connect the Asia Syringe Pump to an electricity source 3 Connect the RS232 communications cable to the rear of the Product Collector and link this with the Asia Automator 4 Connect the BPR to the push fit connector
16. syrris Asia Product Collectors Manual Version 1 0 Author OJ Date 28 09 2012 P N 2000254 Disclosure This document is confidential and is the property of Syrris Ltd No attempt should be made to copy this document in any way without prior consent 2012 Syrris Ltd all rights reserved Contents A MOI ICAO Mi iio iaa rico ca loe iicidds 4 V a a en aE oe en eee ee eee 5 3 Overview of the Asia Product GOl CtOrs veria 7 3 1 Asla Rroquct Coleco tocarlo ol il lavoli dalt aA 7 3 2 Automated Collector RANG C ccccccccccsseeeceeeeeeeeeeeeeeeeeeeeeeseeeeeeeeesseaeeeeeeseeeseeeeeseeeeeeeesseaeeeeeessaaeeeeeessageeeeeeeas 7 3 3 Asia Product Collector Module OVervieW cocccccccccccccccccnnnoononnncnnnnnnnnnononononnnnnnnnnnnnnnnnnnnnnnrrrrnnrrnnnnnnnannnnrnnnnnnns 8 3 4 Manual Product Collector SpeciticaiOnAS ersen a A 9 3 5 Automated Collector Module OvVervieW ocoocccccccccccccooooonnnoncnnnnnnnnnnnnnnnooonononnnnnnnnnnnnnnnnnnnnnnnnrornnnnnannanrrnnnnnnnos 10 3 6 Automated Collector Speclticaloln Stein da led eee 12 3 6 1 e er ed pio 12 3 6 2 PP a A 12 3 6 3 IA A o PP O o ian ated ouaeanidis lulandwanehardantanerh aa a a 12 3 6 4 Common SpecificatiONS cccccscesseceeesccesecceecccesnececsccsseceessoceseeeesscceseceesccsensecessceseeeeesscseeteessosseeees 12 de Quick Stan GUE eeren added asicciida 13 4 1 Asla Product Coletior a 13 4 2 Asia Automated Collector Rang 6 iia as 14 5 Using theAsia Pro
17. table 100V to 240V AC 50 60Hz power source Syrris Ltd Asia Product Collectors Manual Chapter Using the Asia Product Collector Figure 21 Figure 22 Figure 23 Figure 24 Page 15 of 27 5 1 1 Connecting the BPR In order to regulate pressure in the flow chemistry system the BPR back pressure regulator is used The Pressure Controller Manual explains how to operate the BPR and it is best practice to locate the BPR at the end point of the fluidic path Figure 25 In most cases it is a requirement to attach the BPR to the Asia Product Collector 1 Rotate the Product Collector so that the BPR holder is accessible 2 Hold the BPR to the front of the holder and the push fit fitting to the rear and place together through the BPR holder Figure 25 3 Push the two fittings together Figure 26 Figure 27 A click will indicate that both fittings are now connected Figure 26 4 The pressure is achieved and controlled from the Pressure Controller module Attach the tubing from the rear of the Pressure Controller and connect the orange fitting to the rear of the BPR Figure 28 This should be screwed in finger tight Figure 27 Figure 28 L NOTE although it improve performances it is not mandatory to use BPR with the Product Collector If you don t want to use the BPR ignore this section Syrris Ltd Asia Product Colle
18. tain a push fit connector to situate the BPR beside the 3 way valve 1 Connect the BPR to the push fit connector Figure 45 This is situated on a bracket on the product collector moving arm When connecting the BPR it is important to support underneath the product collection arm when inserting the BPR in the connector 2 Connect the gas line from the back of the Pressure Controller to the fitting situated beside the BPR Figure 46 6 1 2 Attaching the Collection Waste Fittings The 3 way valve located on the collection arm switches position between Collect and Waste during operation from Asia Manager software There are 2 connections to make on the 3 way valve 1 Connect the fitting from the outlet of the BPR to the side port of the valve Figure 47 2 Connect the orange fitting to the output at the top of the valve to waste collection 3 The fluidic connections are complete Syrris Ltd Asia Product Collectors Manual Chapter Using the Asia Automated Collector Figure 45 Figure 46 Figure 47 Page 22 of 27 7 Maintenance 7 1 Cleaning the system To ensure good working condition of the Asia Product Collector Range please clean after use 7 1 1 Flushing the 3 way valve After each experimental run flush the 3 way valve by pumping through clean solvent for 1 minute During the cleaning flush switch valve between the waste and collect positio
19. trol switch on valve head H 400mm x W 160mm x D 265mm Display 26mm x 88mm LED display Voltage input 100V 240V AC Syrris Ltd Asia Product Collectors Manual Page 9 of 27 Chapter Overview of the Asia Product Collectors 3 5 Automated Collector Module Overview All Automated Collectors have a similar set up valve and BPR assembly The following figures show the Asia Automated Collector Mini as an example lt Fluidic input from reactor 3 way valve BPR back pressure regulator v tes Bl y Sample collection pipe Product collector Vials moving arm Vial collection tray Manual node Delaved Tube 1 Adv The front of the Asia Automated Collector Mini Figure 8 Syrris Ltd Asia Product Collectors Manual Page 10 of 27 Chapter Overview of the Asia Product Collectors Communication port to connect to Asia Automator via RS232 The rear of the Asia Automated Collector Mini Figure 9 Waste pipe 3 way valve Sample collection pipe Product collector moving arm The valve and connections of the Asia Automated Collector Mini Figure 10 Power supply Inlet from Reactor to BPR BPR back pressure regulator Connection from BPR black fitting to valve Vial collection tray Syrris Ltd Asia Product Collectors Manual Chapter Overview of the Asia Product Collectors Page 11 of 27 3 6 Automated Collector Specifications 3
20. ueeeneeceneeetsaseetanseetsneeetseeees 26 Syrris Ltd Asia Product Collectors Manual Page 3 of 27 Chapter Introduction 1 Introduction Thank you for purchasing an Asia Product Collector or Asia Automated Collector from Syrris These instructions have been carefully prepared to guide the installer and end user through the installation and use of the Asia Product Collector and Asia Automated Collectors Before attempting to use this product please read this manual thoroughly and follow the instructions carefully In doing so you will ensure the safety of yourself and that of others around you and you can look forward to your purchase giving you long and satisfactory service Please keep the manual easily accessible and in immediate vicinity of the module Only suitably qualified and trained personnel should operate this unit Syrris Ltd Asia Product Collectors Manual Chapter Introduction Page 4 of 27 2 Safety Warning and safety information A A A A A A A A A This equipment should only be used by competent suitably trained personnel after they have read and understood this manual and considered any hazard involved Place the instruments on a solid horizontal fire proof surface Ensure the area around the unit is clear Adequate protection including appropriate PPE and ventilation must be provided if hazardous chemicals are to be used in conjunction with this unit In the case of accidental spillage car
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