ULTRANEB Large Volume, High Performance
Contents
1. uU LT RAN E Large T High Performance Ultrasonic Nebuliser ULTRANEB Ultrasonic Nebuliser Introduction 1 Aerosol Inhalation is a preferred route for the delivery of pharmaceutical compounds to the lungs when treating various respiratory diseases In the development and improvement of drugs e g antibiotics hormones peptides and proteins the inhaled route gains more importance There is also an increasing trend in using the lungs as a way of delivering systemic drug therapy Inhaled insulin has been successfully administered and is likely to become an alternative routine treatment to injecting for the treatment of diabetes aardlus ii ULTRANEB Ultrasonic Nebuliser Introduction 2 The delivery device chosen must be adapted and matched with the specific drug formulation in order to achieve a high efficiency and economic use of the drug substance It is necessary to work in close contact with a pharmaceutical partner in order to develop and optimise the inhalation system Aerosol Therapy ULTRANEB Ultrasonic Nebuliser Effective drug deposition 1 Particles larger than 5 Aerosol drug delivery microns are deposited in the d allows treatment to be a arete lle alee ine to side effects directed to directly to the site of action minimising systemic dilution and undesired amp 2 mceron particles side effects a Rapid relief of symptoms and good tolerance due to reduced2. Rail clamp for equipment rail 25x10mm Reducing coupling 25mm 22mm Spare parts Sterilizable 300mm tube sterilizable autoclavable Sterilizable 1200mm tube sterilizable autoclavable Nebulizing Chamber without transducer and Lid Ultrasonic Transducer Bacterial Filter Clamps package of 4 Clamping wheel Five feet stand with 50mm wheels and 1200mm support Stainless steel Support 25mmx600mm Pin joint arm with adjusting ring Stainless steel nebulizer chamber retainer Standard Lid Continuous filling Lid Chamber Lid regulator connection tube with cannula bottle holder stainless steel with adjustment ring Rubber feet PC Board Display board Power Level Set Cooling fan suppresor socket heater jack Patient fan Transformator Ribbon cable Cover Pricing UltraNeb Accessories Part number 2100 11 0 000 2002 02 1 550 2002 02 1 560 2002 02 1 306 6003 07 0 000 91306 25 2002 02 1 146 2002 02 1 147 2002 02 1 058 2002 02 1 250 2002 02 1 350 7108 20 0 000 91018 00 351 1 20 0 000 3001 32 1 100 5003 63 0 000 3151 02 1 100 2002 02 1 150 2002 02 6 600 3101 02 1 200 91480 14 05 2010 00 2 002 99 98504 00 0 001 99 2002 02 1 400 98503 00 0 010 99 98506 00 0 002 05 2002 02 1 018 2002 02 1 021 98507 00 0 001 99 98501 00 0 002 99 2010 02 1 100 99 EUROPEAN List Price 227 14 184 36 256 24 0 91 37 18 10 50 7 92 23 27 75 37 124 51 11 09 11 17 3
3. e Medication Chamber e Not all drug formulations available Size baffles flow from fan e Drug preparation required ainda i ULTRANEB Ultrasonic Nebuliser Medical Indications Uses Asthma Acute bronchitis Chronic bronchitis Cystic fibrosis Tracheotomy Laryngitis Pharmaceutical Research ULTRANEB Ultrasonic Nebuliser E MEDICAL ULTRANEB Variations Base Model Desktop Version Wall rail 5 Foot Stand U3000 U3000DA clamp option Version U30005S 6003 07 0 000 All available with the heated tube option add H eg U3000H eco ltl ULTRANEB Ultrasonic Nebuliser E MEDICAL Heated tube option Requires ULTRANEB heated tube Heater connection Aerosol Therapy ULTRANEB Ultrasonic Nebuliser UltraNeb Front panel Operating mode incl level 1 4 of mode Yellow LED Fault Condition Red LED Standby mode Green LED O I Standby mode Timer O I Output Air Flow 15 30 46 60 0 performance 4 Steps up to a Minutes 4 Steps max 20 L min aff ULTRANEB Ultrasonic Nebuliser UltraNeb Rear Connections Mains Power Fuse Holder and adjustable Mains Switch I O voltage selector 110 127 230V gt l ll err l j 4 iA 4 f 4 br Heated tubing Stand fitting connector Mains Power Connector ULTRANEB Ultrasonic Nebuliser Alarm functions The ULTRANEB h
4. form of dry aerosol particles suitable to inhalation Dry Powder Inhalers DPI s Disperse small powder particles for inhalation into the lung Shear forces generated by the patients inhalation flow are used to disagglomerate the drug particles which are commonly lt gt adhered to carrier particles Nebulisers There are two type of medical nebulisers the jet Nebuliser and the ultrasonic Nebuliser which derives the energy required to aerosolise drugs from high frequency sound waves Aerosol Therapy ULTRANEB Ultrasonic Nebuliser Jet Nebuliser vs Ultrasonic Compressor nebulisers work by using compressed air to break down the liquid into particles that the patient can then inhale Ultrasonic nebulisers work by using a crystal that vibrates when an electric current is passed through it This vibration breaks down the liquid into particles for inhalation Aerosol mist of small particles Fine jet holes with gap between them p T Larger Particles a Liquid drug solution Meqative pressure effect suction Driven by compressed air or oxygen Small Particles Forming hist ae E Base of Me bulising ee igui ae R t t gt ULTRANEB Ultrasonic Nebuliser Why use an Ultrasonic Nebuliser Ultrasonic nebulisers use ultrasonic vibrations to turn a liquid medication into an aerosol Using this method to produce an aerosol makes the particles much more uniform in size This in t
5. systemic side effects are the main advantage of aerosol therapy in comparison Spia or soar tO the oral application deposition route ULTRANEB Ultrasonic Nebuliser Effective drug deposition 2 The deposition of aerosolised drug in the lung is determined by different factors Patient related and drug device related The individual lung anatomy and breathing manoeuvre of the patient have a major impact on drug deposition The design an Quality of the device as well as the interaction of drug formulation and device play an important role Crucial parameters include particle size delivery efficiency and delivery rate An inhalation system has to produce a particle size distribution suitable to the lungs Ideally the diameter of the aerosol droplets should be in the range of 1Mu to 5Mu respirable fraction Particles in this size range will be deposited primarily by sedimentation in the peripheral lung regions the broncholi and alveoli Sedimentation is the major mechanism of deposition in the therapeutic use of aerosols Aerosol Therapy ULTRANEB Ultrasonic Nebuliser Delivery systems Three systems are widely used for the delivery of aerosol medication e Pressured metered dose inhalers pMDI s the drug is either suspended or dissolved in a propellant and filled under pressure into a canister Releasing a metered volume of the fluid causes the propellant to expand and evaporate rapidly leaving the drug in the
6. 00 0 00 2002 00 5 201 2100 mm tube 1200mm tube user manual power 11 0 000 cord UK cord must be added bacterial filter 5 foot trolley Stainless steel support pipe Pin joint arm wth adjusting ring ULTRANEB Ultrasonic Nebuliser Pricing UltraNeb Products Description Part number Products Basic unit longterm nebulizing lid 300 mm 2010 00 0 00 tube 1200mm tube user manual power cord UK power cord bacterial filter Desk model Accessory Stainless steel 2002 00 3 200 support pipe 25 x 600 mm Pin joint arm with adjusting ring Stainless steel infusion hook with adjusting ring Stainless steel nebulizer chamber retainer 5 Feet 5 foot trolley 2002 00 5 200 Stainless steel support pipe Pin joint arm with adjusting ring Stainless steel infusion hook with adjusting ring Stainless steel nebulizer chamber retainer Heated version heatable tube 2100 11 0 000 Aerosol Therapy EUROPEAN List Price 1413 33 179 19 305 38 227 14 INTERNATIONAL List Price 1824 19 231 28 394 16 293 17 UNITED KINGDOM List Price 975 20 123 64 210 71 156 73 ULTRANEB Ultrasonic Nebuliser Aerosol Therapy Description Accessory Silicone tube heatable 1200mm Nebulizer Chamber complete Chamber standard Lid with 5mm tubes O ring ultrasonic Transducer Continuous filling set complete Chamber Lid cannula O ring Ultrasonic transducer Mouthpiece 22mm connection
7. 82 197 87 20 67 136 95 46 89 68 97 169 60 46 89 2 33 220 48 166 77 172 07 44 27 181 05 63 11 87 34 136 74 63 25 123 17 INTERNATIONAL List Price 293 17 237 96 330 73 47 98 13 55 10 23 30 03 97 27 160 71 14 32 14 41 4 93 255 39 26 68 176 76 60 52 89 02 218 90 60 52 3 01 284 57 215 25 222 10 57 14 233 68 81 45 112 73 176 49 81 63 158 98 UNITED KINGDOM List Price 156 73 127 21 176 81 0 63 25 65 7 24 5 47 16 06 52 00 85 92 7 66 7 70 2 63 136 53 14 26 94 50 32 35 47 59 117 02 32 35 1 61 152 13 115 07 118 73 30 55 124 92 43 54 60 27 94 35 43 64 84 99 ULTRANEB Ultrasonic Nebuliser UltraNeb Brochure UltraNeb High Performance Large Volume Ultrasonic Nebuliser ULTRANEB Ultrasonic Nebuliser UltraNeb Wall Posters Ad campaign UltraNeb ai Ja j ther infon ation contact devilbiss sunmed co uk all 44 0 1384 446858 fax 44 0 1384 446628 ULTRANEB Ultrasonic Nebuliser Slide Cover Introduction 1 Introduction 2 Effective drug deposition 1 Effective Drug deposition 2 Delivery systems Jet Nebuliser vs Ultrasonic Nebuliser Why use an Ultrasonic Nebuliser Advantages and Disadvantages of Ultrasonic Nebulisers 10 Medical Indications Uses 11 UltraNeb Variations 12 Heated Tube option 13 UltraNeb Front panel 14 UltraNeb Rear connections 15 Alarm func
8. Comprising of 2010 00 0 1413 33 1824 19 975 20 tube 1200mm tube user manual power cord 00 UK power cord bacterial filter Basic Unit Heated version heatable tube U3000H Comprising of 2010 00 1640 48 2117 36 1131 93 longterm nebulizing lid 300 mm tube 0 01 2100 11 0 000 1200mm tube user manual power cord UK cord must be added bacterial filter Basic Unit Desk model Accessory U3000 DA Comprising of 2010 1592 52 2055 47 1098 84 Stainless steel support pipe 25 x 600 mm 00 0 00 2002 00 3 200 Pin joint arm wth adjusting ring Stainless steel infusion hook wth adjusting ring Stainless steel nebulizer chamber retainer Basic Unit Desk model Accessory Heated U3000H DA Comprising of 2010 1819 67 2348 64 1255 57 version heatable tube Stainless steel 00 0 00 2002 00 3 201 2100 support pipe 25 x 600 mm 11 0 000 Pin joint arm wth adjusting ring Stainless steel infusion hook wth adjusting ring Stainless steel nebulizer chamber retainer Basic unit 5 Feet Stand ongterm U3000 5S Comprising of 2010 1718 71 2218 34 1185 91 nebulizing lid 300 mm tube 1200mm tube 00 0 00 2002 00 5 200 user manual power cord UK cord must be added bacterial filter 5 foot trolley Stainless steel support pipe Pin joint arm wth adjusting ring Stainless steel infusion hook w Basic unit 5 Feet Stand Heated version U3000H 5S Comprising of 2010 1945 86 2511 52 1342 64 heatable tube longterm nebulizing lid 300
9. as 4 different Alarm conditions No chamber No water or to less water level Set medication time exceeded Unit failure Red LED Lights Alarm sounds for 12 seconds then a 4 second pause and then repeats for up to 2 minutes Red LED remains on permanently until the fault is corrected ULTRANEB Ultrasonic Nebuliser E MEDICAL Chamber configuration options Chamber Standard Long term nebulizing flow fitting for a non collapsing bottle Chamber Long term Long term nebulising flow fitting for collapsing sterile water bag Chamber Sterile Water Bottle Next slide for more details Dispoable medication cups ULTRANEB Ultrasonic Nebuliser E MEDICAL Sterile water Systems available from Tyco Kendall Respiflow MPV Truma ULTRANEB Ultrasonic Nebuliser Technical Data 1 Output ml min MMAD lt 4um Air Flow Up to 20 I min Degree of protection against water IP32 Wight ca 3 5 Kg Dimension WxHxD 20 5x19x31 5 cm power consumption SOVA non heated Version SOVA heated Version Ultrasonic frequency 1 68MHz 5 Aerosol temperature max 37 C continuous operation Sound level lt 35 dB A ULTRANEB Ultrasonic Nebuliser Technical Data 2 Electrical requirements 110V 127V und 230V 50Hz 60Hz Classification MPG lla Class of protection Type B Fuse type IEC 127 T800 L 250 V 2 pieces Operating temperature range 10 C 40 C Opera
10. heory allows more of the aerosol particles to penetrate deeper into the lungs and produces a more effective treatment over a conventional jet nebuliser Small Volume Ultrasonic Nebulisers These devices work in the same principle as the UltraNeb and have the advantage over the Jet Nebuliser Compressor of being smaller quieter and far more portable Unfortunately the small volume nebuliser Cannot produce an aersol output any near the volume of a Jet Nebuliser This severely restricts their use The Ultrasonic nebuliser also has components such as the piezo transducer which are very sensitive expensive and not really suited to a portable device Both Clement Clarke and Omron have now moved away from Ultrasonic devices Schill continues with devices for Cysitic Fibrosis Aerosol Therapy ULTRANEB Ultrasonic Nebuliser Advantages e Little patient co ordination required Factors affecting output from e Small dead volume UltraSonic Tranducers e Quiet e Fluid characteristics e Aerosol accumulates during exhalation e Density viscosity surface e High doses possible tension vapour pressure e No chloroflucarbon release gt Piezoelectric tranducer e Frequency of vibration amplitude of vibration Disadvantages configuration foused or flat e Coupling of medication chamber to transducer e Fast drug delivery e Expensive e Contamination possible e Prone to Electrical and Mechanical Breakdown not our device
11. ting humidity range 0 to 90 RH non condensing Transport u Storage temperature range 20 C to 0 C Storage humidity range 0 to 90 RH non condensing Warranty 2 years ULTRANEB Ultrasonic Nebuliser Comparison ULTRANEB vs ULTRANEB 2000 a Le La a E 11 12 13 14 Aerosol Therapy ULTRANEB Modern Design Digital Controls Heated Tube option Medication Timer 4 Alarm types Audio u Visual Extremely quiet lt 35 dB Low power consumption 50 VA or 80 VA heated version Selectable power input 110V 127V 230V Easy to clean autoclavable Easy changing of the ultrasonic transducer Chamber dishwasher safe Chamber autoclave able at 134 C All distilled Water systems can be used Separate Air path channel for Patient air and cooling ULTRANEB 2000 1 Design gt 10 Years Old 2 Analogue Switches 3 Only cold Version available 4 no Timer 5 Only one LED Alarm 6 Louder noise level 7 Higher power consumption 1 90VA 8 Only 230V or 110V version 9 Only dishwasher safe 10 change of the ultrasonic transducer only for Technician possible 11 Only Hand wash Chamber 12 No Sterile Water use available 13 No separated Air path for patient air ULTRANEB Ultrasonic Nebuliser Pricing UltraNeb Variations EUROPEAN INTERNATIONAL UNITED KINGDOM Description Part number List Price List Price List Price Versions Basic Unit longterm nebulizing lid 300 mm _U3000
12. tions 16 Chamber configuration options 17 Sterile water systems 18 Technical data 1 19 Technical data 2 20 Comparison of UltraNeb vs UltraNeb 2000 21 Pricing UltraNeb variations 22 Pricing UltraNeb products 23 Pricing UltraNeb Accessories 24 UltraNeb Brochure oF ao ee a ULTRANEB Ultrasonic Nebuliser
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