user manual
Contents
1. 25 A E E a E E 25 6 9 Precautions rustico pa 25 B cipem innen ER a EEEa E O RA E E 26 7 General Informatio Met 26 SA O OO E DI E 26 7 9 P ristaltie PUMP acetic etc te iakin aesa a a aa o 07 TA KEYPA A A RN DEOR og Dire ep 28 7 6 Cleaning RR cc 29 TI Precautions for WG AOS serrana UU UI E EEE 30 8 iigol lio leiiqtole qe NETTE a SERE e EE ee ee ne 31 8 1 Steps Tor TrOUDIGShOOI IO seserrconiisala nanasa aaa ias 31 8 2 Obtaining Technical Helpcom n aa 32 8 3 Replacement of E USB ue ede rotar ero cama ici iii 32 8 4 Tro bleshooting Ede RTT SET 33 9 Storage and HralnsporteltlOli u s uude ee pru Rae pREEEIH kEUREETes ebEd su CERE peur E tr rE B rex Ern 35 BT SIDU A A E E EIU E 35 Que PENS ONO spree sere eet cicadas aeuum S ne epa Un dota cu desta CU NE i ul UE deste 35 AppendixA List of Replaceable Components sssssesseeeeee 36 Appendix B Item Sequence and Abbreviation ococcccccccccncncncncncncncncncononcncnenenonos 37 Copyright and Declaration Copyright URIT Medical Electronic Co Ltd URIT Thank you very much for your purchase of the BIOLAB 310 chemistry analyzer All contents in this manual were strictly compiled according to the related laws and regulations in china as well as the specific condition of BIOLAB 310 chemistry analyzer covering all the updated information before printing URIT is fully responsible for the revision and explanation of the manual and r2. Ground the instrument using the onboard ground pole If the problem persists contact URIT BIOLAB 310 Operating Manual 9 Storage and Transportation 9 1 Storage The packaged instrument should be stored in a breezy room with the temperature of 20 C 55 C relative humidity lt 95 Stroge mixed with poison injurant and corrosive is forbidden The storage life is 15 years Using the instrument beyond expiration date may fall short the precision In this case itis recommended to check the instrument before operation 9 2 Transportation The transportation must strictly follow the terms and conditions specified in order contact Transportation mixed with poison injurant and corrosive is forbidden Transportation environment 40 C 55 C RHs 95 BIOLAB 310 Operating Manua 35 36 Appendix A List of Replaceable Components T800mAL 250V Power input is 220V T1A 125V Power input is 110V amarse P Step motor Pump With plug Power cord Connestingcable Mainboard 10 _Amplityingboara o Lo fpe p Pumpsubassembly IE E m BIOLAB 310 Operating Manua Appendix B Item Sequence and Abbreviation 01 ALT Alanine aminotransferase 02 r GT r Glutamyltranspeptidase 03 ALP Alkaline phosphaatase 04 CHE cholinesterase 05 D Bil Direct bilirobin 06 T Bil Total bilirobin 07 ALB Albumin 08 TP Total protein 09
3. BIOLAB 310 Operating Manual 1 Technical service and troubleshooting are provided by URIT If the instrument has malfunction please contact the agency authorized by URIT If the problem cannot be solved through telephone directions professional technician and sale representative will be sent to offer you timely service ud URIT Medical Electronic Co Ltd Add No 4 East Alley Jiuhua Road Guilin Guangxi 541001 PR China Tel 86 773 2883225 Fax 86 773 2804668 Web www urit com E mail service uritest com Supplied by URIT Medical Electronic Co Ltd lec REP Wellkang Ltd t a Wellkang Tech Consulting Suite B 29 Harley Street LONDON W1G 9QR UK Version 200808 BIOLAB 310 Operating Manual Preface This document is the operating manual for BIOLAB 310 Chemistry Analyzer It describes in detail the structure operation maintenance and troubleshooting concerning the instrument User should operate the instrument following the instructions in this manul Markings YEN Danger High voltage Power off AN Burn Power on N Caution Grounded Biological Hazard A 9 W Recovery pem In vitro diagnostic Serial number aud Manufacturer ww VN Protect from heat and radioactive sources T Ec REP Authorized representative in European Community BIOLAB 310 Operating Manual 3 Safety Guidelines Before using the instrument be sure to read the precautions below If they are neglected human injury or instrum
4. Perform WASH 10 15 times with absolute alcohol 3 Shut off the power supply Wipe the appearance of the instrument with clean gauze or gauze moistened with water or disinfector when necessary A Biological Hazard Do not discard the used gauze at will after wiping the instrument Dispose of it according to relevant regulations 7 6 3 Monthly Cleaning 1 The operation is the same as weekly cleaning 2 Inspect the cell for air bubble and foreign bodies BIOLAB 310 Operating Manual ER 7 7 Precautions for Usage 1 30 Free from dust and moist Air conditioner is recommended The optimum ambient temperature is 15 25 C Free from electric leakage and static electricity Make sure the instrument is well grounded For the absence of earth wire on the power socket the ground pole outside the instrument should be grounded to ensure safety and stability It is suggested that the electrical receptacle be for instrument exclusive use Be sure to use certified and qualified reagents Reagents taken out from icebox should not be used immediately until they reach the room temperature To avoid confusion different samples should be registered with different IDs After turning on the instrument execute WASH and wait for half an hour prior to routine test After work execute WASH several times BIOLAB 310 Operating Manua 8 TROUBLESHOOTING Your BIOLAB 310 Chemistry Analyzer will give you troublefree operation if you fol
5. C RH lt 80 21 Power Supply AC 100 240V 50 60Hz Fuse varies with different power input refer to Appendix A for details 22 Atmospheric Pressure 75kPa 106kPa BIOLAB 310 Operating Manual 1 4 Principle and Appearance 1 4 1 Principle Beer s law When a parallel monochrome light beam goes through an light absorbent object gas liquid or solid some photons are absorbed and the light intensity decreases from lo to The formula is I lg KLC I 0 K Absorbance coefficient L Thickness of object C Concentration of object lo Intensity of shoot in light I Intensity of shoot out light Measure I lo and L and then calculate C according to the formula above Data conversion is outlined as below Figure1 vg A la nm HE gt gt PA V Selective Filter and Amplifier Focus System y Y Digit Area Figure 1 1 4 2 Appearance Figure 2 and Figure 3 show the appearance of the instrument front and rear BIOLAB 310 Operating Manual Printer Cover Windo START Butto Figure 2 Parallel port Power socke Waste outlet Power switch Fuse box RS 232 Grounded pole Figure 3 BIOLAB 310 Operating Manual 2 Unpacking and Installation A CAUTION User shall not attempt installation of this instrument after its delivery The service representative will install the instrument for its safe and exact operation Before installation user shall make
6. relevant regulations 3 Wash instrument 10 20 times 4 5 Clean worktable with soft cloth Cut off power supply BIOLAB 310 Operating Manual 4 Operation Details The Main Menu includes following six submenus Item Test Curve Test ABS Test Result Data QC Date and Maintenance Following is the detailed description 4 1 Item Test 4 1 1 Setup of Item Parameters Setting item parameters is an essential step for item measurement Proper item parameters can ensure the measurement accuracy You can select item parameters by moving the cursor J turn to other pages by pressing PgDn For editing the parameters of the selected item press the ENTER key After edit Press ENTER to save ESC to cancel and return 1 Item Name The item name can be entered using the cursor and numeric keyboard displayed on the screen 2 Test Method Four methods are available Endpoint kinetic Twopoint and Bichwave Dual wavelength 3 Wavelength 1 and wavelength 2 Both wavelength 1 and wavelength 2 has the range of 300nm 800 nm Wavelength 2 is available when Dual wavelength method is active 4 Time DELAY s For endpoint and dual wavelength delay time is the length from the moment the sample is pipetted into cell to the beginning of measurement for kinetic and twopoint delay time is the length from the moment the sample is pipetted into cell to the beginning of the first point measurement MEAS TIME s The measuremen
7. the beginning of measurement For TIME method the delay time is the length from the moment the sample is aspirated into cell to the beginning of first point measurement 3 Meas time measuring time The measuring time only applied to TIME method is the length from the first point being measured to the last point being measured Other parameters setup are the same as 4 1 1 Setup of Item parameters 4 3 2 Process of ABS test Press F3 RUN from the ABS Parameter screen to start testing The system will prompt to pump water and test the absorbency of water before the sample absorbency test ZERO Zeros the water blank or reagent blank REPT Repeat the test OUT Prints test result 4 4 Result Data 4 4 1 Result Review Press 4 from the Main Menu screen to enter the Review screen The latest result will be displayed at first including sample ID item name test result unit prompt and measuring date Displays the previous stored result 4 Displays the next stored result OUT Prints test result ID Enters sample ID to print specified test result 4 4 2 Result Print Pressing F3 OUT from the Review screen all test results that are subject to the displayed measuring date will be printed Or you can just print the specified results by pressing ID to enter the desired sample ID following by pressing OUT BIOLAB 310 Operating Manua 4 5 QC Data QC data of 300 items can be stored in
8. when redissolving the freeze dried control sample e Store the control sample according to requirement do not use the expired products e Testthe control sample in the same condition as patient sample 5 2 3 Setup of QC Target and Control Limit The QC target and control limit value can be obtained from the control sample manufacturer or from the following methods e Setup of temporary target value Test a new lot of control sample Obtain the results of at lest 20 control tests and calculate their mean value and standard deviation SD as the temporary target value and temporary SD respectively e Setup of regular target value Obtain the accumulative mean values of the original 20 data and all the tested data collected for 3 5 months as the regular value and SD respectively BIOLAB 310 Operating Manual e Setup of control limit A new lot of control sample is required to confirm the control limit that is usually denoted with the multiple of SD The control limit of different items quantitative test depends on their QC regulations 5 2 4 Control Procedure In Item Test press F5 QC from the Testing screen to test the control sample The QC results will be stored automatically in memory for further analysis 5 3 Analysis of QC Results 5 3 1 Entry of QC Target and SD In QC Data press F2 IN from the QC screen to enter target and SD value 5 3 2 Analysis of QC Chart Press F5 PLOT from the QC screen to display the QC
9. Function keys Fl F5 Corresponds with the operation prompts displayed on the lower of the screen There are some operation prompts displayed in different screens but in common use such as ENTER key For entering into edit status and confirming entry ESC key Exits the current status returns to the last screen WASH Washes the cell with distilled water or detergent PgDn PgUp Displays the next last screen PUMP Aspirates sample RUN Starts testing REPT Repeats testing QC Performs quality control analysis DEL Deletes selected item e 1 Moves cursor up e Moves cursor down BIOLAB 310 Operating Manua 3 2 Startup Turn on or off the instrument by pressing the power switch on the rear of the instrument denotes ON O denotes OFF 3 3 Preparations 1 Check if the waste bottle is full and if so empty the waste bottle then prepare enough distilled water 2 Wash the instrument with distilled water by executing the WASH function from the Main Menu screen The instrument then goes into standby status 3 Keep standby status for 30 minutes until the light source is stable and the temperature reaches the expected level 4 Clean the instrument with distilled water by executing WASH five times 5 Select MAINTENANCE from the Main Menu screen to enter the Maintenance screen Then select A D ADJUST to enter the A D screen Press F5 ADJ to automatically adjust the A D After adju
10. OPERATING MANUAL BIOLAB 310 Chemistry Analyzer BIORAYS PAKISTAN www biorays com pk Table of Contents Copyright and Declara OM sarao ares 1 ri qe 3 BAG IOS e E 3 Safety Guidelines E 4 t General Description ai ii A A A A AL 6 Ti rs CAU OS OPA Prom 6 1 29 GUNG ere A A T E ce T S Specification ME OEme 7 1 4 Principle and Appearance sss meme hee eene 8 2 Unpacking and Installation omiosbmmiscioiic ri e dins ett 10 A nie PEN CE 10 2 2 T Veen MNO ooo tare E D LL EM M ME atc 40 9 ODeOratlon Bref osuna idas 12 3 1 Explanation ol ROY OG ps saesae cut a EE a aE 12 ASTA NEG AEA uo E 12 3 3 PEDIA UDS api ev geese ee vert detec estate erect MTM ENS 43 3 4 Setup f o AAPP o Ao 13 SERI air old 43 3 6 Print ING REVIEW P 13 calci c en bade 44 SES cip cr e 15 4T tem A aK aK E se eer eee eee eae ARENA te 45 A o o nn rennet 47 4 3S ABS A 17 sd Rai Data nn I MTM 18 4 5 QC Dala RC ee A A 49 SESRIIIDI UST ls 19 MEET EU A e S SUI UT UT 21 5 OC Analysis and all bet loti A htm piget 22 O General MTOR IVT HOA sses asrnane danaa RT 22 5 2 QCand QC A 22 5 9 Analysis o QU RESUS eene ce agunune eos 23 5 4 Treatments tor Abnormality sorda rra ds 23 55 GalibEabllO us tia Table of Contents 6 Reagent Sample and Waste eee races ern iia 25 A A o
11. UREA Urea 10 BUN Blood urea nitrogen 11 Cr Creatinine 12 UA Uric acid 13 CO2 CP Carbon dioxide combining power 14 GLU Glucose 15 CHO Cholesterol 16 LDL C Low density cholesterol 17 HDL C High density cholesterol 18 TG Triglyceride 19 CI Chlorine 20 Ca Calcium 21 Fe Ferrum 22 P Phosphor 23 Mg Magnesium 24 AST Aspartate aminotransferase 25 LDH L Lactate dehydrogenase 26 CK Creatine kinase 27 CK MB Creatine kinase MB isoenzyme 28 a HBDH a hydrooxybutyrate dehydrogenase 29 LD 1 Lactate dehydrogenase 30 PK Pyruvate kinase 31 Ams Amylase Blood 32 Ams Amylase Urine 33 Ams Amylase 34 Hb Hemoglobin 35 CO2 Carbon dioxide 36 ACP Acid phosphatase BIOLAB 310 Operating Manual d Tel 66 773 2683225 Fax 86 773 2804668
12. ata and controls light signals and temperature etc Temperature control system Controls the temperature in the cell LCD Displays test results and operating information Printer Prints test results keypad For entering numerical digits and commands BIOLAB 310 Operating Manual 1 3 Specifications 1 Light Source Halogen lamp 6V 10W 2 Wavelengths 300nm 800nm 3 Assay Methods Endpoint absorbance kinetic two point dual wavelength etc 4 Measuring Range 0 3 3 0Abs 5 Resolution 0 001Abs Display 0 0001Abs Interal calculation 6 Drift 0 003Abs 20min 7 8 Sampling Volume 100u L 9999y L auto compensation 500p Lis recommended 0 Flow Cell 32u L quartz cell Optical path 10mm 9 Temperature Control Room 25 C 30 C 37 C 0 1 C 10 Cross contamination s 196 Repeatability CVs 1 096 Memory 0 999sec variable 11 12 13 Memory Up to 320 items and 20 000 test results 14 Export Standard RS232 interface and parallel interface LPT 15 Software The system management software includes QC and statistic program which can display item curves and QC curves and print the latter 16 Power Dissipation 130VA 17 Dimension 392mm 375mm 205mm length width height 18 Weight About 7 7Kg 19 Insulation Limit for External Circuit lt 0 10 under single fault condition 20 Ambient Extreme Temperature 5 C 40 C Recommended Temperature 10 C 30
13. bes 3 Carefully dispose of wastes as they may carry potential contaminations and cause biologic and chemical hazard Obey local regulations to dispose and drain the waste solution 4 Store reagents according to the instructions offered by reagent supplier User should establish and maintain the keeping and using system for reagents to avoid using expired reagent Storage should keep away from extremely hot or cold environment BIOLAB 310 Operating Manual 25 7 Maintenance 7 1 General Information To ensure stable system performance and prolong use life it is necessary to strictly follow the maintenance instructions in this manual For problems that cannot be solved in this chapter please contact your local distributor or URIT N CAUTION Do not perform any maintenance not specified or authorised in the manual to the instrument or else instrument damage or human injury may be incurred and maintenance commitment in contract will be invalid Most maintenance is carried out with power off and sometimes the instrument should be disconnected from the mains Do not spill water or reagent on the mechanism and electronic components A Biological Hazard Put on protective gloves clothes and even goggles if necessary during the maintenance process 7 2 Printer N NOTE Do not disassemble the printer head at will 1 Turn off the power supply when the printer works out of order 2 When replacing printer paper blow a
14. chart In the QC chart the middle line denotes the target value while the lines up and down denote 1SD 2SD and 3SD 5 3 3 Normal Distribution e About 95 data are within X 2SD e 5continuous data in the same side are not allowed e 5 continuous data step up or step down are not allowed e 2 continuous points outside X 2SD are not allowed e Points outside X 3SD are not allowed 5 3 4 Abnormality e Drift System error exists e Tendency change The capability of reagent or instrument has been changed e Precision change Accidental error is large e g the instrument or reagent shows instability 5 4 Treatments for Abnormality For abnormality carry out following procedures to deal with 1 Fillin abnormality report and report to your lab manager 2 Simply and quickly review the operation process to find out the possible cause 3 If no evident error is found take the following steps BIOLAB 310 Operating Manual ES e Retest the same control sample strictly as the operation procedures If the retest results are normal it means that personal error or random error existed in previous testing If the retest result still falls outside the allowable range proceed to the next step Testa new bottle of control sample If the test results are normal the previous bottle of control sample has expired or been contaminated if the test result still falls outside the allowable range proceed to the next step Testa new lot o
15. ent damage may be caused A CAUTION If user dose not follow the instructions presented in this manual when operating the instrument the protective measures provided by the system may be failed Preventing electric shock AN CAUTION When the power supply is on DO NOT open the instrument cover other than the authorized maintenance man If liquid leaks inside the instrument cut off the power supply immediately Improper manner may cause electric shock and system damage Preventing eye injury MA CAUTION When the instrument is active do not directly look at the light emitting from the lamp source which may cause injury to your eyes Preventing chemical injury A Biological Hazard If chemical adheres to the human body infection may occur Do not directly touch the sample mixed solution and waste solution Be sure to put on protective gloves clothes or even goggles when necessary Some reagents are strong acid or basic Please use them carefully and avoid direct contact If the reagent sticks to hands or clothes immediately wash it off with water and soap If reagent splashes into eyes accidentally wash it off with water and consult an oculist BIOLAB 310 Operating Manual Disposing waste solution Biological Hazard Discharge and disposal of reagent control solution calibration solution detergent and waste solution are regulated by certain standard provisions Please observe the local regulation to discard wa
16. enter the Testing screen Place the sample under the probe then press the START button the instrument then automatically perform measurement according tothe preset item parameters If there are more than one test to be done the tests will be processed following the sequence blank standard samples If blank and standard parameters are set up in advance REPT If you have doubt in test result press F4 REPT to retest the sample The retest result will replace the previous one PLOT Press F2 PLOT to enter the Reaction Curve screen where the reaction curves are presented in real time for convenient observation BIOLAB 310 Operating Manual ID You can edit sample ID by pressing F1 ID After edit press ENTER to save or ESC to cancel The subsequent sample ID will automatically add 1 each time a sample is tested QC Pressing F5 QC the system prompts to perform QC test Refer to Chapter 5 for details 4 2 Curve Test Press 2 from the Main Menu screen to enter the Curve Item screen This function is mainly used for testing samples that need 2 5 standards to calibrate 4 2 1 Setup of Standard Curve Up to 20 standard curves for 20 items can be created and the item parameters are user defined The minimum of two standard samples Maximum five are available Standard concentrations should be entered in ascending order If you predefined the ABS just enter it So far the curves are created If you do not k
17. eserves the right to renovate the relevant contents without separate notice Some of the demonstration pictures in this manual are for reference and subject to real object if any differences All the information included is protected by copyright No any part of this document may be reproduced stored or transmitted in any form or by any means unless written authorization by URIT All instructions must be followed strictly in operation In no event should URIT be responsible for failures errors and other liabilities resulting from user s noncompliance with the procedures and precautions outlined herein Limitation of Liability URIT warrants to the original purchaser that this instrument will be free from defects in materials and workmanship for a period of one year from the later of the date of original purchase or installation URIT assumes no liability in the following situations even during the period of warranty 1 Failure due to abuse the instrument or neglect the maintenance 2 Use reagents and accessories other than manufactured or recommended by URIT 3 Failure due to operate not under the instructions described in the manual 4 Replace accessories not specified by URIT or after maintenance or repair by a service agent not approved or authorized by URIT NOTE URIT makes no warranties either express or implied as to product quality performance and value as a commodity or applicability for any particular purpose
18. f control sample If the test results are normal the previous lot of control sample has problem Inspect the storage environment and expiration date for possible cause If the test result still falls outside the allowable range proceed to the next step Maintain the instrument Inspect the instrument status and check whether it is necessary to replace the light source and filter clean cell or change reagents Test control sample after maintenance If the test result still falls outside the allowable range proceed to the next step Perform recalibration Recalibrate the instrument with new calibration solution If the test result sill falls outside the allowable range proceed to the next step Obtain help from technician If the test result still falls outside the allowable range after the five steps above the instrument or reagent may be to blame Contact URIT or reagent manufacturer to get more technical help 5 5 Calibration The calibration sample is to minimize or eliminate the system error caused by instrument or reagent It is recommended than human serum matrix be used to reduce the matrix error 5 5 1 When to Calibrate It is suggested that calibration be carried out every six months or under the following conditions 1 When initially installing and running the instrument 2 When changing the reagent type or lot unless otherwise specified by the laboratory that the change will not influence the precision 3 When carr
19. han 5 meters 14 Operating temperature should be within the range of 5 C 40 C with fluctuation lt 2 C IH 10 BIOLAB 310 Operating Manual 2 2 2 Procedures of installation 1 Take out the instrument and place it on the level stable worktable For heat dispersion the rear of the instrument should keep away from wall or obstacles at least 20cm The bottom of the instrument should keep good air circulation 2 Insert the power cord in the power input terminal on the rear of the instrument 3 Connect the joint end of the waste tube to the waste outlet and the other end to the waste bottle 4 Before initial running check the waste tube for bend and jam and make sure the waste solution can be discharged into the waste bottle smoothly 5 Before operation warm up the instrument for 20 30 minutes until the temperature is balanced and the light source is stable BIOLAB 310 Operating Manua 11 12 3 Operation Brief AX siotoctca Hazard To avoid infection put on protective gloves clothes and even goggles when To avoid unnecessary damage to the instrument please read the Operating Manual carefully before operation 3 1 Explanation for Keypad The keypad is shown as Figure 4 for example E E E D Ee my EIE Lee 5 m ENTER Es PLE 7 Figure 4 1 Digit keys 0 9 For entering digits 2 Radix point key For entering radix point 3 4 5
20. join with each other totally 7 Aim the center of the pump at the motor shaft and press the pump until it is set on the base 8 Connect the tubes back to the pump 7 3 2 Step Motor Pump 1 Drain off the liquid from path open the window on the left of the instrument and disconnect the tubes connected with the pump Unscrew the two screws on the fixing Clip 3 Take out the pump tube and replace it with a new Circle the new tube around the pump head and clip it with the adjustable clip Screw the fixing clip but DO NOT block the reel of the pump head Pump head Fixing clip Upper cover clamps Adjustable clip Pump tube Base clamps E N pes Upper cover A Lower cover i i Pump tube a i N TeS Wheels Closing rings Pump 4 i Figure 6 1 DC Motor Figure 6 2 Step Motor Pump Pump BIOLAB 310 Operating Manual d 7 4 Keypad Ashort tone shall be heard when gently pressing the keypad DO NOT press it hardly 7 5 Cell If the test result is not exact and stable the unclean or damaged cell may be to blame for If the test result is not yet satisfactory after rinsing the cell replacement of cell is possible The precisely designed flow cell Figure 7 with a stainless steel quartz window can keep an accurate heat balance inside The temperature in the cell is controlled by Peltier element For replacement of the cell first open the instrument window Drain off the liquid from the ce
21. ll and path Then press the cell and take off the inlet tube and outlet tube Finally loosen the fixed clips on the cell and take out the cell from the cell hole For installation of the cell properly embed the cell in the hole and fix it with the fixed clip Then connect the tubes back to the corresponding inlet and outlet respectively the inlet is narrow while the outlet is wider P Cell Fixed clip Figure 7 AN caution For cleanliness of the cell do not touch the quartz window After each testing wash the cell and fill it with water before turning off the instrument Wash the cell with detergent at least once every week Aspirate 2ml detergent and keep it in the cell for 5 minutes then wash it off with 20ml water AB siotocica Hazard DO NOT touch the cell directly Put on protective gloves when replacing the cell A NOTE Improper installation of cell may influence the accuracy of test result 28 BIOLAB 310 Operating Manua 7 6 Cleaning A Biological Hazard Put on protective gloves during cleaning If chemical sticks to human body wash it off with water immediately 7 6 1 Daily Cleaning 1 Wash 10 15 times after turning on the instrument and 10 20 times before turning off 2 Empty the waste bottle 7 6 2 Weekly Cleaning 1 Aspirate detergent containing active enzyme to soak the cell for certain time not a long time if the detergent is strong caustic Then wash the cell with water several times 2
22. low the directions for using and cleaning the instrument If an operational or instrument problem occurs however an alarm will be heard along with a prompt message of the problem This section of the manual lists the various errors and messages along with probable causes and recommended remedies to quickly and easily correct the problem If the problem persists after following the recommended remedy contact URIT Customer Service office for assistance The troubleshooting is based on the replacement of components The major replaceable components are listed in Appendix A MA CAUTION Make sure the power supply has been cut off before maintenance NM Hazard Put on protective gloves clothes and even goggles when necessary 8 1 Steps for Troubleshooting In general you can follow the three steps below to carry out troubleshooting The First Step Confirming Malfunction You should first have an idea of the malfunction what the instrument should be when it is in order The Second Step Classing Malfunction The instrument malfunction can be classed into three categories 1 Malfunction relating to hardware 2 Malfunction relating to software 3 Malfunction relating to operation If the malfunction relates to the hardware or software contact your URIT Customer Service office If the malfunction relates to the operation refer to this section for solution The Third Step Eliminating Malfunction The maintenance man authorized b
23. memory for 2 months Press 5 from the Main Menu screen to enter the QC Item screen Select an item by entering the number ahead of each item then press the ENTER key to show the QC screen If you pre define the target value and SD value the QC chart will be plot using those entered values if not the QC chart will be plot using the mean value and SD automatically calculated by system MEAN The automatically calculated mean value or the manually entered target value the latter has the priority of display SD The automatically calculated SD value or the manually entered SD value The latter has the priority of display CV CV of QC data QT QUANTITY the quantity of current QC data y Turns to QC data of another month DEL Deletes QC data PLOT Displays QC chart OUT Prints QC data IN Enters QC target and SD values 4 6 Maintenance This function is intended for instrument maintenance and debugging Press 6 from the Main Menu screen to enter the Maintenance Submenu screen 4 6 1 A D Adjust The A D initial value of the instrument has been adjusted before leaving factory The gain A D and dark level values vary with different filters Generally the gain is 3 or 4 the A D is about 34000 and the dark level is within 70 130 never 0 this profile is the optimum initial values Pressing F5 ADJ the system will automatically adjust the gain and dark level for different filters After adjustment
24. nd immunology tests on a variety of clinical samples such as serum urine cerebrospinal fluid and plasma The instrument is only for professional in vitro use in hospitals clinics and laboratories 1 1 Features Various assay methods Endpoint kinetics two pont dual wavelength absorbance etc Optional calculation methods Reagent blank and sample blank are available Calculation methods include factor single point calibration and multi point calibration etc Data bank Test results item parameters and item settings are stored in the memory permanently for further analysis and statistics Powerful software Item parameters are user defined and can be saved permanently User friendly interface Menu led operation All information such as operating prompts status indications QC calculation test results etc is displayed on the LCD Data can be exported through the internal printer or via the RS 232 and parallel interfaces Computer control Computer control is available through relevant software 1 2 Structure The instrument is mainly composed of sampling system cell system MCU system temperature control system LCD printer and keypad etc Sampling system Aspirates sample into cell and drains waste into waste bottle Cell system Includes light source filter cell light signal sensor etc Light signal is transformed into electric signal here MCU system Collects system signals processes d
25. now the ABS or if you want to recalibrate just enter the standard concentrations then set the ABS to 0 0000 The system will prompt to perform standard test before sample test The standard results will be saved and standard curves are created 4 2 2 Process of Curve Test After setup of parameters press F5 RUN from Curve Parameter screen to start testing System prompt will be displayed if parameters are inadequate In this case press ESC to return and complete the parameters entry Test result will be displayed after testing REPT If you have doubt in test result press F4 REPT to retest the sample The retest result will replace the previous one PLOT Press F2 PLOT to enter the Reaction Curve screen where the reaction curves are presented in real time for convenient observation ID You can edit sample ID by pressing F1 ID After edit press ENTER to save or ESC to cancel The sample ID will automatically add 1 each time a sample is tested Pressing the radix point key on the keypad will compulsorily print the current test result even when the printer is set OFF 4 3 ABS Test Press 3 from the Main Menu screen to enter the ABS Parameter screen BIOLAB 310 Operating Manual 17 4 3 1 Setup of Parameters 1 Test Method ABS Absorbance of sample TIME Change rate of absorbance 2 Delay For ABS method the delay time is the length from the moment the sample is aspirated into cell to
26. orks while lamp Defective lamp Please contact URIT Pressingthe START 3 key noliquid is aspirated 1 The pump is not installed well 2 Deteriorated or cracked pump tube 3 Improper parameter for the pump k Reinstall the pump properly 2 Replace the pump tube 3 Set up proper parameters for the pump 4 If the problem persists contact URIT No water runs out Air Leakage with tube Reconnect the tube A D Adjustmentfailed insufficient or air bubbles exist in the cell 3 Dirty cell AM 2 Replace the pump tube 4 when rinsing 2 Deteriorated and cracked tub 3 If the problem persists contact pump tuag URIT 1 Contact URIT 2 Drain off water from the cell 1 Defective lamp then aspirate water again and E 2 Water in the cell is perform adjustment If still failed reset the parameters of pump 3 Wash the cell with detergent or absolute alcohol several times 4 If the problem persists contact BIOLAB 310 Operating Manual 33 34 4 Improper item Set proper item parameter SN SYMPTOM POSSIBLE CAUSE REMEDY 1 Air bubble in the cell 1 Rinse the cell with medical alcohol and water respectively 2 Deteriorated or cracked tub 2 Replace the pump tube Inaccurate test results puna M ii 3 Adjust A D value 6 or poor repeatability 3 Defective lamp 5 parameters 5 Power supply without earth wire
27. preparations for satisfying the installation requirements in accordance with this manual 2 1 Unpacking Please check the carton according to the following procedures 1 Carefully unpack the package and take out the BIOLAB 310 Chemistry Analyzer and the accessories 2 Inspect the instrument and accessories for quantity and visible signs of damage according to the accompanying Packing List 3 If any loss or damage exists contact the distributor or manufacturer immediately 2 2 Installation 2 2 1 Requirements of installation 1 Only for room installation and use 2 Worktable must be level with gradient less than1 200 3 Good ventilation for the room 4 Free from direct sunlight and dust 6 7 No shake with the worktable 8 Free from strong noise and electricity interference 5 Free from corrosive and flammable gas Free from hot and wind source 9 Keep away from brush motor and the electric equipment that are turned on or off frequently 10 Keep away from electromagnetic wave equipments such as mobile phone wireless transceiver etc 11 Power supply AC 100 240V 50 60Hz three core power cord grounded 12 A well grounded electrical receptacle is required and its maximum power consumption is 1kVA zero to earth voltage is lt 6V The instrument should be connected with an exclusive cable if possible 13 The distance between electric receptacle and the instrument should be less t
28. reliability of test results depends on two aspects One is precision i e the repeatability of test results which mainly aims at eliminating or minimizing the influence caused by random error and depends on the sound room QC system to guarantee The other one is accuracy i e the test results are correct and close to the true values which mainly aims at eliminating or minimizing the influence caused by system error and depends on the proper assay method and calibration to guarantee Therefore it is necessary to strictly select certified control sample and calibration solution and use them according to their instructions 5 2 QC and QC Procedure To minimize test error it is required to keep the control sample stable in storage 5 2 1 Class of Control Sample e Mixed serum freeze dried and liquid control sample classified by the different physical properties of control samples e Fixed value and non fixed value control sample classified by the presence and absence of measurement value You can select one kind of control sample listed above as the room control sample as required 5 2 2 Usage and Storage e Strictly use control sample according to the instructions provided by the control supplier Make sure the high quality of the solution redissolved from freeze dried control sample Make sure the added volume is accurate and consistent each time redissolving the freeze dried control sample e Fierce shake is avoided by all means
29. ste or consult the reagent supplier or distributor Intended use JAS CAUTION The instrument is mainly intended for quantitatively measuring the serum plasma urine and cerebrospinal fluid etc If the instrument is to be used beyond this scope consult URIT first Take clinical symptoms and other test results into consideration before making any clinical determinations Installation N CAUTION Installation not complying with the specified requirement in this manual will cause erroneous test result or even damage to the instrument If relocation is necessary contact URIT or your local distributor firstly Usage A CAUTION Failing to operate the instrument as the instructions presented in the operating manual will cause erroneous result or even damage to the instrument and injury to the operator 2 For the first time using the instrument perform calibration and QC tests before sample tests 3 QC test should be done before sample tests or else inexact results may occur 4 Use the special connecting cable provided by URIT to connect the instrument with computer Do not pull out the connecting cable before cutting off the power 5 DO NOT touch the LCD or keypad with wet or chemical stuck hands BIOLAB 310 Operating Manual 1 General Description The BIOLAB 310 chemistry analyzer for short is intended for use in instrument conjunction with certain reagents to quantitatively perform chemistry a
30. stment ashort toneis heard and the adjusted A D value is saved automatically If problems occur during the adjustment referto Troubleshooting 3 4 Setup of Item Parameters Press 1 or 2 from the Main Menu to enter the Item Screen Each item is marked with a number Item ID ahead Enter the desired item ID then press the ENTER key to display the relative Item Parameter screen Refer to chapter 4 1 1 for details Refer to Appendix B for item sequence and abbreviation 3 5 Item Test Press the F1 RUN from the Item Parameter screen Place the sample under the probe then press the START button on the instrument The instrument will automatically aspirate sample and measure it according to the preset parameters If you need to cancel the measurement in the progress press the ESC key 3 6 Print and Review After measurement return to the Main Menu Press 4 RESULT DATA to enter the Review screen The latest test results are displayed first and other results can be reviewed by pressing the t or 1 Pressing the OUT key will print all test results that are subjectto the date displayed on the current screen If you just want to print the result of a specified sample press the ID key first to enter the desired sample ID then press the OUT key BIOLAB 310 Operating Manual 13 3 7 Ending Follow below steps after daily work 1 Put reagent into icebox 2 Dispose of used serum cuvettes according to
31. t time only applied to kinetic and twopoint is the length from the first point being measured to the last point being measured 5 Blank Blank mediums include reagent distilled water and sample Accordingly blank methods include reagent blank water blank and sample blank 6 Volume The volume of reaction solution to be aspirated BIOLAB 310 Operating Manua 7 Units Units for test results 8 Temperature Temperature choices include Room 25DC 30DC and 30DC 9 Print Turns on or off the printer Selecting ON test results will be printed out following each measurement Selecting OFF the printer will not work NOTE In RESULT DATA press ID will print the comprehensive report See chapter 4 4 2 for details 10 Standard Standard concentration used for calculating K value 11 Factor Factor is the K value It can be entered manually or calculated automatically by the system after a standard test For the latter when the standard concentration has been entered and the K value is 0 a standard test is required by the system before sample test is done After the standard test the system will calculate the K value automatically NOTE Factor method is available After completion of parameters setup you can select following operation RUN Starts testing current item WASH Rinses the liquid path with water or detergent ESC Returns to Main Menu 4 1 2 Process of Item Test Press the FI RUN to
32. the buzzer rings and the adjusted values are saved as reference for future adjustment NOTE Press F4 PUMP to fill the cell with water before adjustment SET This function is only for factory debugging use TEST This function is only for factory debugging use It is suggested to adjust initial value under following situations When installing the instrument BIOLAB 310 Operating Manual 5 After long distance delivery When replacing a halogen lamp When replacing a cell When filer has deteriorated Whenever test results show abnormal fluctuation 4 6 2 Pump Adjust This function is for adjusting the parameters of peristaltic pump It is not necessary to change the parameters in general circumstances as they have been set up to optimum condition by the factory 1 Volume Liquid volume usually 500 uL pumped at a time If the volume is 1000uL the pump needs to move twice 2 Speed The speed of pump motor 3 Step The moving step for pump motor 4 Wash times The wash times for liquid path 4 6 3 Temperature Only for factory debugging use 4 6 4 System 1 LCD Contrast Move cursor to SYSTEM then press ENTER to enter the Contrast screen Increases the LCD contrast Decreases the LCD contrast SAVE Saves the adjustment ESC Cancels and exits the current screen 2 Language Select language for user interface English is default BIOLAB 310 Operating Manua 3 PC Control Moving c
33. ursor to PC CONTROL and pressing ENTER the instrument is controlled by PC Pressing ESC cancel the PC control 4 Printer Move cursor to PRINTER and press ENTER to change the selection between ON and OFF 5 RS232 Serial Port Move cursor to RS232 and press ENTER to change the selection between ON and OFF 6 LPT Parallel Port Move cursor to LPT and press ENTER to change the selection between ON and OFF 4 6 5 Date amp Time Move cursor to DATE TIME and press ENTER to enter the Date amp Time screen Move the cursor to the appropriate digit that needs to be changed Then enter the appropriate digits by pressing the proper numeric keys 4 6 6 Calibration Only for factory debugging use 4 7 Tube Wash Washing tube frequently can keep the tube and cell clean and reduce cross contamination Place water or detergent under the probe then press the WASH key which is displayed on various screen The instrument will then automatically wash the tube Itis recommended to wash tube in the following situations Atthe start of day s run Atthe end of days run After testing high concentration solution Along time for disuse e Abnormal A D values N CAUTION For the air bubble or foreign body that is difficult to wash off from the cell try to use the absolute alcohol or detergent recommended by URIT BIOLAB 310 Operating 21 Manua 22 5 QC Analysis and Calibration 5 1 General Information The
34. way the wastepaper on the printer head if any 3 Keep the printer circuitry away from dust Installation of Printer Paper 1 Open the printer cover 2 Trim the front of paper into a Vshape shown as figure 5 3 Take out the printer header and insert the paper into the formfeed entrance until several inches of paper are exposed above the printer Figure 5 BIOLAB 310 Operating Manual 7 3 Peristaltic Pump The peristaltic pump Figure 6 1 and Figure 6 2 is an important part for liquid flow If the pump tube is old or wore out replacement with the same model is necessary Replace the pump tube as following steps 7 3 1 DC Motor Pump 1 Drain off the liquid from path open the window on the left side of the instrument and disconnect the tubes connected with the pump 2 Forcibly nip the two clamps on the pump base with your thumb and index finger and then take out the pump from the base 3 Forcibly nip the two clamps on the upper cover of the pump with your thumb and index finger and then take out the lower cover 4 Take down the wore pump tube from the upper cover then take down the two closing rings from the wore tube and clip them in the new tube 5 Push the new tube into the interspace between the wheels and the inner wall of the upper cover Hold down the two closing rings to clip the outlet of the upper cover with the opening upward 6 Join the upper cover with the lower cover Forcibly press until the covers
35. y URIT will take proper measures to get ride of the malfunction User can also eliminate it under directions of maintenance man BIOLAB 310 Operating a Manua 8 2 Obtaining Technical Help If you the problem is beyond the scope of this manual and you need technical assistant from URIT our Customer Service office is available to help Before calling please identify the following information 1 The instrument model 2 The serial number of the instrument 3 The specific symptom 4 The data and reports relating to the malfunction 8 3 Replacement of Fuse For replacement of fuse open the fuse box and replace a new fuse shown in Figure 8 Power Interface Cover of Fuse Box Power Interface Fuse Fuse Box Figure 8 N CAUTION Be sure to cut off the power supply before replacing the fuse A N NOTE DO NOT damage the fuse box or the power interface when replacing the fuse 2 BIOLAB 310 Operating Manual 8 4 Troubleshooting Table Table 1 lists the various malfunction along with probable causes and recommended remedies for user to quickly and easily correct the problem If the problem cannot be solved or additional assistance is required concerning an instrument problem contact URIT Customer Service Office does not Table 1 SN SYMPTOM POSSIBLE CAUSE REMEDY 1 Replace the fuse T 0 8A delay 1 Fan and lamp do not Fuse problem fuse Work 2 f the problem persists contact URIT Fan w
36. ying out a protective maintenance or replacing an important component which may influence the instrument capability 4 When QC chart reflects abnormal tendency and drift or exceeds the allowable range and it can not be corrected by routine steps 5 5 2 Calibration Procedure In Item Test enter the concentration value given by the calibration sample supplier into the STANDARD field Save and exit The calibration will be automatically carried out before testing sample and the result will be stored as reference for the next calibration It is suggested that all calibration or validation work should be written down and compiled into documents What should be emphasized is that the fix value serum should never be used as calibration sample because the huge difference between 24 BIOLAB 310 Operating Manua 6 Reagent Sample and Waste 6 1 Reagent The reagent parameters are customized Only the certified and qualified reagents can be used Carefully read the instructions provided by reagent supplier before use 6 2 Detergent Detergent is optional 6 3 Precautions 1 When performing tests and daily maintenance be sure to obey the operation procedures and avoid contacting samples directly 2 All clinic samples should be handled according to the operation regulations as they may carry potential infectious disease Put on protective clothes gloves and goggles No smoking and eating in working area Do not blow or suck the tu
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