Bioengineering RALF
Contents
1. Ze NY y i ry V Y W L H NN N l h T S lt J N overing every ti oen lneerine LR ight Orwaro strai orld a stallation guide 2 4 M e o A M d Mit AA M we nm a E installation and training instruct your team and2. d x j D oF N T IF fi ARN Y f j N N N My ey AE IR I i fa f Fk Fos Poe T Porapak 8 i f l C yf he d f 4 7 H j N P png l E j d l IB E RT J d y jJ j f It ox y POE do I j y Fou 3 X J el EN A ZN y J AVE Cg J E 4 ouod j Fu X f P Kou X fff DINA IF rg TE 1 l I j j j ARN a o ee a J D d bay d U N i N i j U Ay EA A Y L 4 A E PI ttt d Remove In the unlikely event of any electronic failure the control unit can be detached from the utility lines removed from the housing and if necessary replaced with a new unit all within minutes k M T VA k 1 UNA y ALLY Vda YA Modular design Solid Swiss democracy means that you shall have your say in modular configuration A wide range of modules offers you enough choice to match our equipment to your needs optimally and from the first step Bioengineering RALF Modular and yet individual Vessel The autoclavable glass vessel is featured with a hemispherical bottom and is available in single or double jacket versions The stainless steel lid enables the hygienic connection of all probes metered inlet outlet piping as well as all gas supply and exhaust lines A high performance Temperature control Multiple temperature control systems are avail able They all ev
3. 7 SN N N NAR N Y Y under control SxxXXNNX o7 o Y Y y Y Y SSSSnn a ae ee E yr BioSCADA RALF is based on our proven BioSCADA software which was designed to meet today s Our process d utomation al lows for optimum process flow Pi ae challenging demands for laboratory and production systems around the world thanks to top g rade measu ring nd control units in conjunc _ This outstanding BioSCADA system incorporates the cumulative experience acquired over years of ai ae development from end users and partners in all fields of operation It guarantees you the best link tion with easy to handle bioprocess management software between scale up and scale down as well as advantages in operator training usability and main tenance that lets you monitor and record everything according to your choice Bioengineering BioSCADA RALF and supervisory control e Each Bioengineering RALF comes with BioSCADA RALF the most comprehensive and intuitive bioprocess management software on the market Whether your process is simple or sophisti cated BIOSCADA RALF will always adapt to your requirements e BioSCADA RALF permits full process automation including advanced recipe functions batch recording user management audit trail report generation as well as other key features to meet the high demands of the 24 7 industry environment It requires no previous bioprocess software or programming knowledge whatsoever to use successfully
4. Y E c G pn Z Y Z G P IT 5 P Cr fect proportions Balancing proportions our desire to create optimum conditions for your processes Bioengineering equipment accommodates any type of process and at the same time satisfies your striving for an appropriate fusion of functional design and optimum size Bioengineering RALF requires little space even in multi unit configurations Compact design Our layout with the vessel in front of the contro tower and central connections for all probes utilities ensures accessibility from all sides as well as a fast and easy set up A slim control tower with a small footprint minimizes the space requirements in your lab The vessel slims down for autoclaving Collapsible reflux cooler Thanks to flexible hose couplings the reflux cooler is attached to the control tower during the fermentation process but can quickly be detached and laterally positioned on the vessel wall for sterilization in an autoclave This unique feature drastically reduces the total height of the vessel assembly needed for autoclaving Flexible configuration Autoclavable medium and feed bottles with filters can be clamped onto the vessel If desired they can easily be detached and repositioned anywhere else you see fit This further reduces the space required in an autoclave y 18 A nu s Everything set in place Vertically retractable handles reduce the
5. baffles Our new temperature control system achieves two sided temperature control but in a single wall vessel This leads to a shorter autoclave time and lower overall vessel costs while providing highly uniform temperature distribution previ ously obtained only in double jacket vessels Double jacket vessel For shear sensitive processes a heating loop combined with a double jacket vessel assures uniform temperature distribution within the vessel even for smaller working volumes Heating pad An electric heating pad with cut outs for obser vation heats the vessel quickly and efficiently Cooling is provided by a valve controlled cooling finger Exact comparability of configurations Scale up and scale down Bioengineering covers all possible demands from lab to production From software measurement and controls to probes spargers and agitators the Bioengineering RALF is a true production bioreactor providing perfect scale up conditions Ss gen z JW e y d Xf NES SSS i JJ V vie f N F iS Ee A Al im I7 i ib A __ _Quality in Premium Swiss workmanship ensures impeccable hygienic design k Welds Every Bioengineering RALF is 100 Swiss made by experienced specialists Only the highest hy gienic design standards and superior materials are used Including clean
6. d surface aeration high intensity aeration tubes and spargers for minimized bubble sizes even at low speeds The exhaust gas flow is dehumidified in a reflux cooler before going through the exhaust filter To analyze the 02 and CO2 concentrations in the exhaust stream a Bioengineering Exhalyzer can be integrated into the system at any time with out additional software modifications accurately controlled speeds an extra free standing pump with local display and operating elements can be added to the configuration This is useful for highly accurate continuous or profile dependent metering It is also possible to assign all pumps freely to various control loops and change their tag in the software optimally addressing process requirements related to corrective agents and nutrients The BioSCADA RALF software has a user friendly interface which permits fast and direct access to the process including comprehensive analyses documentation and management of all current and historic process data Further features of the software include online export of open process data to Excel and the generation of readily avail able batch reports Furthermore the definition of sequential algorithms and recipes without programming skills are part of the functions along with alarm and user authorization level management Full access to the individual controllers is pro vided via easy to handle input and display fields With these fields you ca
7. e Multiple built in analysis options give you a perfect overview of your process and the ability to export your data into any given format e BioSCADA RALF allows total connectivity add calibrate name and access external devices to use them as inputs or outputs in your control strategy Most reliable and durable probes from best in class suppliers e We use solely the best and most advanced probes on the market It goes without saying that easy recalibration the ability to run probe diagnostics with software and extended longevity are our standard for this critical piece of the bioreactor RAT Achse md Colt n 4012012 1 41 00 B on Batch report wayt 201208 21 119748 19 Uno Hardware control loops e Each control loop is independently managed in the hardware of Bioengineering RALF meaning gei I manner that setpoints are saved in the actual controllers and not just in the software Free input and output for external devices such as scales Exhalyzers VOC probes etc e he O package also includes multiple free digital and analog inputs outputs Via standard input output signals connect external devices such as scales additional probes Exhalyzers for CO2 02 concentration analysis or any other tool able to communicate with the Bioengineering RALF universal controller Our professional customer support is part of the package Put your trust in us and expect fast expert and efficient
8. enly heat the reaction space and maintain the desired temperature with a high degree of accuracy This can be done with a cooling finger in combination with a heating maintenance free motor centrally positioned on the lid covers a vast speed range and can drive height adjustable impellers of various types A hygienically designed mechanical seal or mag netic drive ensures that the vessel is completely sealed off and sterile pad Alternatively a water loop with a recircu lation pump keeps the temperature constant via the double jacket vessel or perfused baffles all without obstructing the ability to view the re action space Aeration Up to six gas lines can be combined for multi ple aeration strategies The wide choice of gas flow combinations provides you with the flexi bility to deploy the same fermenter for micro bial processes as well as for cell cultivation if desired The gas lines are laterally positioned on the side of the control unit in expandable or interchangeable modules This allows you to control the flow rate and the pressure of the gas mixture injected into the process Using solenoid valves or mass flow controllers you can easily automate all gas lines and integrate them into Addition transfer Up to seven peristaltic pumps guarantee the precise minimally pulsed delivery of medium and correction fluids such as acids alkalis or antifoaming agents from ancillary glass fla
9. n preset control parameters specify alarm thresholds diagnose and calibrate probes and define cascades and profiles The media and variables displayed on the graphical user interface can be named according to your preferences The consumption of all correction media is also accessible with the BioSCADA RALFsoftware Individualize your Bioengineering RALF Vessel options Multiple interchangeable mixing elements such as Rushton marine and pitched blade impellers enable high flexibility for optimized mixing Adition transfer options Fermenters can be equipped with different addition transfer systems such as a perfusion filter The result is the efficient cultivation of different cell cultures as well as a wide range of microorganisms Control unit options Conveniently expand the scope of your functionality by simple plug n play for a large variety of external devices Aeration options Choose from multiple aeration systems for the best possible and most efficient aeration strategy necessary for different microorganisms and cell cultures Flexibility is our response to your innovative pow Our options bear witness to the wide scope of our systems and offer optimum upgrades for your equipment any time Upgrade kits SAN oH meno Og Aeration upgrade kits Advanced products permit any combination of up to six gases with a vas
10. precision welding and flawlessly designed connections and ports Gaskets and ports Gap free and hygienic sealing is assured by positioning O ring gaskets close to the medium side The form of the ports permits simple and reliable installation of lid components even in limited space environments At Bioengineering there is quality in the details rather than the devil Your quality standards inspire us to go the extra mile In accord ance with the Swiss tradition of commitment to quality our materials and manufacturing procedures are subject to strict quality control NW etail Bioengineering guarantees the best conditions from start to finish Engineering and manufacturing Every Bioengineering RALF is carefully designed to the highest standards by our dedicated staff and subject to benchmark quality assurance Each product arrives ready for use and promises optimal research conditions upon delivery Best of class suppliers Our premium bioreactors use only the highest quality parts Certified suppliers with decades of experience in bioprocess applications are carefully selected to maximize reliability and enhance the overall user experience Convenient interfaces allow simple removal of vessels Drive Our maintenance free high duty agitator has plug n play coupling with the shaft Set up and disassembly is completed in a mere matter of seconds Addition transfer hoses Bioengineerings unique p
11. required autoclave space They also provide convenient access to lid ports during assembly and inocu lation Smart SNe solutions Plug n Play Connectivity at your fingertips We take SMART literally by every single letter The solutions we offer are Specific Measurable and Accepted throughout the industry as well as Reasonable well established and technically mature and Time oriented promptly delivered within the requested time frame Connections for multiple Bioengineering RALF systems Using shared utility connections for multiple Bioengineering RALF systems employing 2 6 units requires less space and fewer utility requirements while also providing an easier and faster means of assembly Switch from microbial to cell cultivation and vice versa Due to its modular design and the wide variety of gas modules one can choose from each Bioengineering RALF is capable of delivering both high and low vvm rates Thus the same bioreactor can be utilized for either microbial fermentation or cell cultivation x LE A ee m j Upgrade Due to built in interfaces the Bioengineering RALF can easily be upgraded at any time Various pump modules and addition transfer upgrades are available for basic and advanced models A wide variety of gas module upgrades with selectable flow rates covers the full range of requirements in advanced models Three temperature control options Hollow
12. service Tf cH CEA LTM Zam H N WS m 7 v Ml l i j N I l Y A A 31 pull ce a 8477 SSS RE AS AZ INNANI AN ZN AJN P n zs y H MZ L AE Y Af E 4 ei E oL I gt gt Bae 8 oo 2 0 Em D U vr LL U K O oo c E C L gt v Q gt I i p o c L G CC E Q O O y voc oHG 6 nA c D 2 gt Cn O 5 B co 0 us 2 o C mU c ov Z S o gt k YA E las p u i En gt a UE O le 0 S i A ud 4 gt UD U af c Hii ae Oe M S Gc gt 2 10 S 0 N 2 i U U l u x tgopO d so 2 vor sens vs2z g9 85E As ar 2275 a 9 DU ISS ESA gt D aun See 28 05 gt 3500 o I Eloy 783 0 Z oa WH CU QA U oe A e Pom LY G S QN S af es fo FE Sa c S U 0 5 wo SF 5280958 5 U C o o i IM de c 5 Un u U Cn 3 lt n y un e O o gt gt QU uL E i 4 OX 5 0 Se O lt o 6 O GO CEN 6 2 a A 8 E e e o Local support ge ner L5 pg E Y dk With over 40 years lations in over 70 cou authorized Es 7 7 M m a MY GEL ae representativ Bioengineering backs up our equipment with fast and Support IG MM GN L ix location ith si _ Pc CNN D gt EA a Aw uL HTT Z WILL
13. sks Also included is the extraction and transfer of culture fluids from the vessel The fixed or variable speed pumps are integrated into modules that are mounted on the side of the control unitand can be combined in various ways For a particularly wide range of flow rates and Control unit Each Bioengineering RALF is equipped with basic control loops that can be expanded depending on your needs for additional measurements and functions Aside from speed temperature pH pO2 level or foam controllers you can add an O mod ule with universal controllers for measuring O2 and CO2 concentrations in the exhaust stream the redox potential or alcohol concentrations The simple plug in connection for scales of all capacities enables precise feeding or chemostat cultivation if desired The interfaces of the control unit are accessible via plug connectors and the control software is designed to accommodate additional para meters This allows you to broaden the scope of functionality at any time with plug n play simplicity Connections for analog and digital valves or switches are available as well Together with the control software these features support the swift and flexible configuration of control loops correlating internal or external measuring points valves pumps or even subordinate controllers your control strategy Several different options are available to assure optimized aeration for any culture submerged an
14. t range of flow rates Should process requirements change you can easily upgrade or replace gas modules at a later stage PPP lt lt lt Addition transfer upgrade kits Pump upgrade kits enable easy upgrade of addition transfer capabilities these connect up to seven pumps which can be added on later For more detailed information please refer to Module Options N ZA Te UN Vessel kits Users are completely free to configure their vessel kit which can be used as a backup vessel or to avoid downtime during autoclaving IT 1 eas m A Zn V X S OR i j X N LD A j NA N X a fi j f E i N AI f f f f A N E SP l pH d l MN N u f gt X N NN NX Y f gt N N N x Y x Nx f NON TN x X N P X NA of y j gt N N TN N A NL P i E With us you don t need to be a control freak to have everything Automation ED UBS P E Z E
15. ump head design enables users to simply and safely snap on and off their addition transfer hoses while couplings on both sides hold the hoses in place and prevent them from shifting Probes Pluggable connections allow for the quick detachment of the wiring of probes Since all of our plugs visually differ from one another no confusion arises when connecting the vessel Temperature circuit Quick action color coded couplings provide an easy means to swiftly disconnect water loop hoses and prevent uncertainties when recon necting the vessel Easy handling EAS y LE ES E Y yf FEROE X AES Ww J TS oF ot f j j JR V gt Immediate access to the control unit Rotate The control unit s rotational capability of 180 on its pedestal involves minimal effort on the part of the user while providing convenient access to all interfaces valves and other com ponents Tilt forward If required the control unit can be tilted forward to access additional interfaces within the housing for example when upgrading the Bioengineering RALF The control unit is safely attached for risk free work even in the tilted position E UC Ph ux y V g V ae ae gw oJ PIO L fff gt L U E J P FX PR oT ho qq BB j E E LE dE Ee E I FE Gg y
Download Pdf Manuals
Related Search