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MSQ Plus Mass Detector Preinstallation Guide

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1. Preinstallation Guide 60111 97045 Revision A September 2013 DOCUMENTATION 2013 Thermo Fisher Scientific Inc All rights reserved Accela Thermo Scientific and Xcalibur are registered trademarks and MSQ MSQ Plus and Optima are trademarks of Thermo Fisher Scientific in the United States The following are registered trademarks in the United States and possibly other countries Swagelok is a registered trademark of the Crawford Fitting Company Dranetz is a registered trademark of Dranetz Technologies Inc Styrofoam is a registered trademark of Dow Chemical Company Teflon is a registered trademark of E I du Pont de Nemours amp Co Peak Scientific is a registered trademark of Peak Scientific Instruments Limited All other trademarks are the property of Thermo Fisher Scientific Inc and its subsidiaries Thermo Fisher Scientific Inc provides this document to its customers with a product purchase to use in the product operation This document is copyright protected and any reproduction of the whole or any part of this document is strictly prohibited except with the written authorization of Thermo Fisher Scientific Inc The contents of this document are subject to change without notice All technical information in this document is for reference purposes only System configurations and specifications in this document supersede all previous information received by the purchaser Thermo Fisher Scientific Inc makes no representa
2. Fisher Scientific to ensure protections provided by the instrument are not impaired Deviations from specified instructions on the proper use of the instrument include changes to the system and part replacement Accordingly order replacement parts from Thermo Fisher Scientific or one of its authorized representatives Notice on the Susceptibility to Electromagnetic Transmissions Your instrument is designed to work in a controlled electromagnetic environment Do not use radio frequency transmitters such as mobile phones in close proximity to the instrument For manufacturing location see the label on the instrument WEEE Compliance This product is required to comply with the European Union s Waste Electrical amp Electronic Equipment WEEE Directive 2002 96 EC It is marked with the following symbol Thermo Fisher Scientific has contracted with one or more recycling or disposal companies in each European Union EU Member State and these companies should dispose of or recycle this product See www thermoscientific com rohsweee for further information on Thermo Fisher Scientific s compliance with these Directives and the recyclers in your country WEEE Konformit t Dieses Produkt muss die EU Waste Electrical amp Electronic Equipment WEEE Richtlinie 2002 96 EC erf llen Das Produkt ist durch folgendes Symbol gekennzeichnet Thermo Fisher Scientific hat Vereinbarungen mit Verwertungs Entsorgungsfirmen in allen EU Mitglie
3. GAS IN 6BARSMAX 0 AO uss RESET D PUMP OUT USERVO Sn E Note The solvent trap captures the solvent waste that flows from the drain at the bottom of the source compartment and that exits through the exhaust port on the back of the mass detector Edwards forepump MSO Plus Mass Detector Preinstallation Guide To vent for solvent trap exhaust Solvent trap supplied with system Thermo Scientific 6 Waste and Exhaust Solvent Waste Solvent Waste The API source can accommodate high solvent flow rates and is fitted with a drainage port in its bottom Collect the waste solvent that exits the exhaust manifold on the back panel of the MSQ Plus Mass Detector Connect the 19 mm 0 75 in ID drain tube that exits the exhaust manifold to the solvent trap that is supplied with the system The solvent trap is a 4 L wide mouth square bottle with two brass fittings on the top The drainage tubing that extends from the exhaust manifold is connected to one fitting Additional tubing long enough to reach a user supplied fume hood or industrial vent is connected to the other fitting see Figure 8 CAUTION Do not vent the drain tubing or any vent tubing connected to the waste container to the same fume exhaust system to which you have connected the forepump Therm
4. Provision has been made for collecting solvent Q 12 Voltage of power outlet has been measured waste from API source Note measured voltage Q 22 One voice telephone line is installed near the Q 13 Power is free from fluctuations due to slow system changes in the average voltage or changes due L123 All relevant safety regulations are complied with to surges sags or transients Have any special acceptance specifications been agreed to in the contract Yes U No U If YES attach full details of specifications Is there any additional equipment that needs to be interfaced to the system Yes U No LJ If YES attach full details of additional equipment Note We reserve the right to invoice against the engineer s time if the installation requirements are not met on the date of the installation Print your name company name and company address clearly below Name Company Telephone Address Address City State Country Signature Date Chromatography and Mass Spectrometry Offices For up to date contact information visit www thermoscientific com wps portal ts contactus North America United States 1400 North Point Pkwy 10 West Palm Beach FL 33407 E mail us customer support analyze thermofisher com Phone 1 800 532 4752 FAX rss 1 877 373 4006 Canada 2845 Argentia Road Unit 4 Mississauga Ontario L5N 8G6 E mail us customer support analyze thermofisher com Phone
5. at 20 relative humidity can cause as much as 18000 V of electrostatic potential to develop on your skin or 1500 V at 8096 relative humidity Working in laboratory coats and clothing made of synthetic fibers can cause the accumulation of static electricity on your skin e Styrofoam cups and packing materials typically have a considerable electrostatic charge on them The discharge of static electricity is not perceptible to a human being until the potential is at least 4000 V Many electronic components can be damaged by a discharge of electrostatic potential of as little as 50 V ESD damage can be catastrophic causing your system to cease functioning More commonly however ESD damage might cause latent problems that are detrimental to sensitive electrical components causing premature failures Therefore the following precautions are recommended especially when you are operating your system at the lower end of the relative humidity specification listed in section Usea static dissipating floor covering such as tile or conductive linoleum in the room that houses your instrument 12 MSO Plus Mass Detector Preinstallation Guide Thermo Scientific 3 Operating Environment Electrostatic Discharge Use laboratory chairs covered with natural fiber or other static dissipating material When you are operating the instrument wear a laboratory coat and clothing made of natural fiber or other static dissipating material Do not
6. be completed in order to install your MSQ Plus Mass Detector Contents e Preinstallation Survey Installation Kits and Components nstallation Preventive Maintenance Before installation make sure that all preparations described in the previous chapters are complete When you have completed your laboratory site preparation the MSQ Plus Mass Detector Installation Request Form has been mailed or faxed to your local office for Thermo Scientific products and the system has been delivered call your Thermo Fisher Scientific office to arrange for an installation date See the Installation Request Form at the front of this guide Telephone and fax numbers for Thermo Fisher Scientific San Jose offices are listed in the Preface of this guide and immediately following the Installation Request Form Table 14 summarizes information about installing your system More information on each of the items is available on the page indicated in the table Table 14 More information on the installation of your system Sheet 1 of 2 Requirement Page Preinstallation Survey 40 You must complete and fax or mail the Installation Request Form at the front of this guide to your local service representative before the service engineer arrives to install your system Installation Kits and Components 41 Some kits are supplied to help you complete the installation of your system You might require additional parts or chemicals to complete the installa
7. for Mass Spectrometers Dionex MSQISLA Nitrogen Generator for Mass Spectrometers Dionex N118LOA N418LA Unpacking amp Installation Dionex N 18KLA Nitrogen Generator User Manual Dionex MSQ Getting Started Safety and Regulatory Guide You also receive a printed copy of the Safety and Regulatory Guide with your MSQ Plus Mass Detector This guide contains important safety information about Thermo Scientific LC and MS systems Make sure that all lab personnel have read and have access to this document The software also provides Help Safety and Special Notices Make sure you follow the precautionary statements presented in this guide The safety and other special notices appear in boxes Safety and special notices include the following CAUTION Highlights hazards to humans property or the environment Each CAUTION notice is accompanied by an appropriate CAUTION symbol IMPORTANT Highlights information necessary to prevent damage to software loss of data or invalid test results or might contain information that is critical for optimal performance of the system Note Highlights information of general interest Tip Highlights helpful information that can make a task easier xiv MSQ Plus Mass Detector Preinstallation Guide Thermo Scientific Preface Safety Precautions Safety Precautions Observe the following safety precautions when you operate or perform service on the MSQ Plus Mass Detector CAUTION Do n
8. maneuvering the system around corners into elevators or through doorways The MSQ Plus Mass Detector and accessories are shipped in a container with a length of 112 cm 44 in a width of 70 cm 28 in and a height of 78 cm 31 in The container and its contents weigh approximately 60 kg 132 Ib Other modules such as the computer forepump monitor and options are shipped in their own containers Their dimensions and weights are less than that of the container for the MSQ Plus Mass Detector Space and Load Requirements See Figure 1 for the MSQ Plus Mass Detector system installation and space requirements See Table 2 for the space requirements and weights of typical MSQ Plus Mass Detector LC MS system components Your instrument is shipped in a shipping container with a smallest dimension of 70 cm 28 in If the entrance to your laboratory will not accommodate a 92 cm 36 22 in container you can remove the individual modules from the container before moving them into the room If you remove the instrument from its shipping container before it is delivered to the lab site be sure that all the contents of the container remain with the instrument 2 Tf the instrument shipping container Shock Watch or other indicators show any evidence of damage or mishandling during shipment do NOT open the container Call your Thermo Fisher Scientific representative for instructions on what to do If there is no evidence of shipping damag
9. o M RN BM aUS 3 lr PC 4 Space and Load Requirements u see 4 Telephone TTE 7 Operating Environment 9 Temper are AAA rate Eas 10 Humidity iss ree fme etes mee S Bine Ni an 11 Vibe semer rS 11 lighting aan 11 Particulate Matter inch nee ee ee 12 Electrostatic Discharge osos exa oboe a ie odias 12 Line POWER ae ee err re 15 Quality of Bowle een 18 Power Monitoring Devices 18 Power Conditioning Devices iii a 19 AYALA EAS AS AR ER 19 Connecting the MS LC and Other Modules to Wall Outlets 23 Uninterruptible Power Supply isa e jos 24 Technical Assistance aia ek ERO as a ana a ions 25 Gases and SaWwenB ca 27 AS O EEEE E 28 c mm 28 Solvent Recommendations zu 5422414 4404 cea CARE raa dara sad 29 MSQ Plus Mass Detector Preinstallation Guide xi Contents Chapter 6 Chapter 7 Chapter 8 Waste and Exhaust co un obra tures ica SO d qo ani e ne 31 Exhdust System ae doi oven tb en teta oot e ADI it dul c o 32 Forero ee 32 Eleetr spray APCI Exhaust i 2 2a deua Che ae une 34 Solvent Waste ob Ebr hd EHE EA RE RAE Ie EORR ran 35 Instrument Arrival a ai 37 Receiving Materialei ss sia aa E E a Eb RA 37 Domestic Spam s ub qur ee de petrae 37 Int rnational Shipments dass Er ae page ae dr a ORE RR pate F3 38 Installations a A Nee 39 PremistallaviGieSUnvey ic he 40 Installation Kits and Components ca ee ea ees 41 Install
10. pressure decreases as the length of the tubing increases limit the 6 mm OD tubing that runs from the back of the nitrogen generator to the GAS In port on the back panel of the mass detector to no longer than 6 m 20 ft Allow sufficient slack in the gas line so that you can pull the generator forward for maintenance Figure 2 Optional N418LA nitrogen generator Install a telephone in your laboratory near the instrument so that if necessary you can conveniently operate the system while you are working by telephone with Thermo Fisher Scientific Technical Support Place the voice telephone outlet within 2 m 6 ft of your system IMPORTANT Your instrument is designed to work in a controlled electromagnetic environment Do not use radio frequency transmitters such as mobile phones in close proximity to the instrument MSQ Plus Mass Detector Preinstallation Guide 7 Operating Environment Thermo Scientific This chapter describes the operating environment that the MSQ Plus Mass Detector requires to perform optimally Contents Temperature Humidity Vibration Lighting e Particulate Matter e Electrostatic Discharge Attention to the operating environment ensures the continued high performance of your MSQ Plus Mass Detector LC MS system Any expenditures for air conditioning are more than offset by good sample throughput and reduced repair costs See Table 3 for more information on operating environment requiremen
11. site humidity and particulate matter control The a 3 Principal operator will be available during the laboratory can be maintained at a constant installation certification period temperature between 15 and 27 C 59 and Q 4 Doorways hallways and so on are a minimum 81 F width of 94 cm 37 in A 15 Relative humidity is between 40 and 80 with A 5 Available floor area is sufficient and flooring will no condensation support the load A 16 System work area is free from magnetic Q 6 Sufficient bench space is available for all of the disruption and electrostatic discharge equipment List the following Q 17 All gases required argon and nitrogen are on Width site gas lines are installed and appropriate gas Depth regulators are available Height List gases and purity Q 7 Workbench can support the load of the system Q 18 New or recently cleaned HPLC system is 215 kg 470 Ibs and is free from vibration available that produces pulse free continuous O 8 Lighting is adequate flow from 100 to 1000 uL min Q 9 Main power is installed and is in compliance with L1 19 HPLC grade water methanol acetonitrile and local electrical codes isopropyl alcohol are available for testing the Q 10 Power for test and cleaning equipment is performance of your instrument installed U 20 There is a suitable exhaust system present that Q 11 Power outlets are of the correct configuration is separate from solvent waste Note NEMA type A 21
12. 0 Vac service the basic power requirements for a MSQ Plus Mass Detector consist of the following Nominal voltage of 120 Vac 6 to 10 and 230 Vac 10 and free from voltage variations above or below this operating range Frequency of 50 60 Hz Two fourplex outlets single phase power with a minimum power rating of 20 A 120 Vac One fourplex outlet single phase power with a minimum power rating of 16 A 230 Vac In the U S only 15 and 20 A power rating options are available therefore you must choose the 20 A option Earth ground hard wired to the main panel For systems installed in areas with 230 Vac only service the basic power requirements for a MSQ Plus Mass Detector consist of the following Nominal voltage of 230 Vac 10 Frequency of 50 60 Hz Three fourplex outlets with a minimum power rating of 16 A at each fourplex outlet Earth ground hard wired to the main panel CAUTION The MSQ Plus Mass Detector must have an earth ground hard wired to the main panel The interconnected power outlets for the MSQ Plus Mass Detector must have a common point to one ground connector If there are two such points each of which is connected to separate external ground they can cause noise current to flow through the ground system by way of the ground loop that is formed 20 MSO Plus Mass Detector Preinstallation Guide Thermo Scientific Thermo Scientific 4 Line Power Available Outlets Note 1 Keep t
13. 1 800 530 8447 F 3X3 odes 1 905 890 9161 Europe Austria Wehlistrasse 27b A 1200 Wien E mail service sid austria thermofisher com Phone 43 0 1 333 50 34 0 Fax 43 0 1 333 50 34 26 Belgium Clintonpark Keppekouter Ninovesteenweg 198 B 9320 ERMEBODEGEM AALST E mail service sid benelux thermofisher com Phone 32 0 2 482 3030 FAX 2 32 0 2 482 3031 Denmark Fruebjergvej 3 2100 Kgbenhavn Y E mail service sid dk thermofisher com Phone 45 70 236267 FaX n been 45 70 236263 Finland see Sweden Norway and Finland France Also representing French speaking North Africa Algeria Morocco and Tunisia 16 Avenue du Qu bec Silic 765 Z A de Courtaboeuf F 91963 Les Ulis C dex E mail service sid lesulis thermofisher com Phone 33 0 1 60 92 49 50 FAX remis 33 0 1 60 92 48 99 Germany Im Steingrund 4 6 D 63303 Dreieich E mail service dreieich thermofisher com Phone 49 0 6103 408 1050 Fax qe E 49 0 6103 408 1213 Italy Strada Rivoltana I 20090 Rodano Milano E mail assistenza tecnica it thermofisher com Phone Numero Verde 800 823 162 FAX qr 39 02 95320 225 Netherlands Takkebijsters 1 NL 4817 BL Breda E mail service sid benelux thermofisher com Phone 31 0 76 579 55 55 Faxen 31 0 76 581 09 61 Norway see Swede
14. 3 1995 EN 61000 4 6 2001 EN 61000 4 2 2001 EN 61000 4 11 2001 CFR 47 Part 15 Subpart B 2004 Code of Federal Regulations Part 15 Subpart B Radio Frequency Devices Unintentional Radiators Class A Low Voltage Safety Compliance This device complies with the EU directive 73 23 EEC equivalent to IEC 1010 1 1990 plus Amendment 1 1991 and Amendment 2 1995 by meeting the following standard EN 61010 1 2001 with Corrigendum No 1 and 2 FCC Compliance Statement THIS DEVICE COMPLIES WITH PART 15 OF THE FCC RULES OPERATION IS SUBJECT TO THE FOLLOWING TWO CONDITIONS 1 THIS DEVICE MAY NOT CAUSE HARMFUL INTERFERENCE AND 2 THIS DEVICE MUST ACCEPT ANY INTERFERENCE RECEIVED INCLUDING INTERFERENCE THAT MAY CAUSE UNDESIRED OPERATION CAUTION Read and understand the various precautionary notes signs and symbols contained inside this manual pertaining to the safe use and operation of this product before using the device Notice on Lifting and Handling of Thermo Scientific Instruments For your safety and in compliance with international regulations the physical handling of this Thermo Fisher Scientific instrument requires a team effort to lift and or move the instrument This instrument is too heavy and or bulky for one person alone to handle safely Notice on the Proper Use of Thermo Scientific Instruments In compliance with international regulations This instrument must be used in the manner specified by Thermo
15. 8 29 41 requirements 27 sheath 29 MSO Plus Mass Detector Preinstallation Guide 43 Index H H hallways 3 4 40 heat output 11 humidity 9 11 12 40 installation kits 39 41 Installation Request Form iii 39 40 instrument damage 37 instrument installation 39 instrument shipment 37 international shipment of instruments 38 isopropyl alcohol 30 41 L lighting 10 41 line power current 22 electrical outlets 17 19 23 monitoring 16 18 power conditioning devices 16 19 quality of power 18 requirements 15 technical assistance 25 uninterruptible power supply 17 24 voltage 19 voltage levels 16 liquid chromatographs 6 liquid nitrogen 29 liquid nitrogen conversion factors 29 mechanical pump kits 42 media kits 41 methanol 29 30 41 mobile phones 7 MSQ Tool kits 41 N418LA nitrogen generator 7 29 NEMA 5 15P plugs 21 NEMA 6 15P plugs 21 nitrogen gas 41 nitrogen generator 29 nitrogen generators 7 nitrogen regulator adapter 28 noise suppression transformer 16 NPT PTFE nitrogen supply tubing 28 44 MSO Plus Mass Detector Preinstallation Guide 0 operating environment for MSQ Plus Mass Detector 9 P particles 10 12 particulate filters 29 physical site requirements 3 power conditioning 16 power conditioning devices 16 19 power monitoring devices 18 preventive maintenance 40 42 radio frequency transmitters 7 receiving material 37 regulatory compliance vii S safety precau
16. Optima LC MS grade solvents and additives Store and handle all chemicals in accordance with standard safety procedures 30 MSQ Plus Mass Detector Preinstallation Guide Thermo Scientific Waste and Exhaust Thermo Scientific The proper performance of your system can be affected by the waste and exhaust arrangements for the instrument This chapter describes these exhaust and waste system requirements Contents Exhaust System Solvent Waste You must vent vacuum and solvent wastes separately and collect and dispose of wastes properly Table 13 summarizes the exhaust and waste system requirements More information on each of the requirements is available on the page indicated in the table Table 13 Summary of waste and exhaust preinstallation requirements Requirement Page Exhaust System 32 Vent both vacuum pumps and solvent wastes to fume exhausts Connect the pumps to a fume exhaust system that is separate from that to which solvents are vented Solvent Waste 35 Install a suitable container for the solvent wastes with the system A solvent trap is supplied with the MSQ Plus Mass Detector MSQ Plus Mass Detector Preinstallation Guide 31 6 Waste and Exhaust Exhaust System Exhaust System IMPORTANT You are responsible for providing an adequate exhaust system Much of what is introduced into the MSQ Plus Mass Detector is eventually exhausted from the forepump along with the small amount of oi
17. Vac 230 Vac MSQ Plus Mass Detector 3A Liquid chromatograph 5A Cone wash pump optional Nitrogen generator optional 4A Monitor 1A Computer 2A Laser printer 2A Total 5A 7A 5A Approximate The actual value depends on your equipment CAUTION Make sure that the MSQ Plus Mass Detector and your LC are not connected to the same electrical wall outlet circuit Uninterruptible Power Supply If your local area is susceptible to corrupted power or power disruptions install an uninterruptible power supply UPS in your laboratory CAUTION The UPS must be listed or recognized by an NTRL in the USA or by a European Recognized Agency 24 MSQ Plus Mass Detector Preinstallation Guide Thermo Scientific 4 Line Power Technical Assistance Technical Assistance Thermo Scientific You might occasionally encounter line power sources of unacceptable quality that adversely affect the operation of an MSQ Plus Mass Detector Correcting line power problems is your responsibility Contact your local office for Thermo Scientific products for assistance in monitoring the line voltage in your laboratory and in selecting a line conditioner Specifying power conditioning equipment is a complex task that is best handled by a company or consultant specializing in that field Contact your local Thermo Fisher Scientific office for assistance in locating a power consultant in your area MSQ Plus Mass Detector Preinstallation Guide 25 Gases and Solve
18. ail message to the Technical Publications Editor at techpubs lcms thermofisher com MSQ Plus Mass Detector Preinstallation Guide xvii Introduction The MSQ Plus Mass Detector is designed to operate under carefully controlled environmental conditions You are responsible for providing a suitable location and operating environment a source of power of acceptable quality correct gas and solvent supplies and proper waste and exhaust systems CAUTION Operating a system or maintaining it outside the power and operating environment specifications described in this guide might cause failures of many types The repair of such failures is specifically excluded from the standard warranty and service contract coverage For additional information request specific preinstallation support directly through your local Thermo Fisher Scientific office see Chromatography and Mass Spectrometry Offices on page v Thermo Scientific MSQ Plus Mass Detector Preinstallation Guide 1 p Site Preparation This chapter describes the physical requirements that your site must meet to accommodate the MSQ Plus Mass Detector Contents Entrance Space and Load Requirements Telephone Before a Thermo Fisher Scientific service engineer can install your instrument you must prepare the site Transportation of the equipment to the site requires wide entrances and hallways Supporting the weight of the mass detector computer and liquid chrom
19. ation A at 42 Preventive Maintenance 42 jj ge m TEE NOE 43 xii MSQ Plus Mass Detector Preinstallation Guide Thermo Scientific E Preface This guide describes how to plan for and prepare your laboratory site before delivery and installation of the Thermo Scientific MSQ Plus Mass Detector Read each section carefully to ensure that your laboratory is ready for the installation of the system Contents Related Documentation Safety and Special Notices e Safety Precautions Contacting Us To suggest changes to documentation or to Help Complete a brief survey about this document by clicking the button below Thank you in advance for your help SURVEY Related Documentation In addition to this guide Thermo Fisher Scientific provides the following documents for the MSQ Plus Mass Detector MSQ Plus Mass Detector Hardware Manual MSQ Plus Mass Detector Getting Started Guide MSQ Plus Mass Detector Getting Connected MSQ Plus Mass Detector Calmix Kit Preparation Guide Dionex AXP AXP MS Metering Pump Operators Manual Dionex Chromelon MSQ Plus Operators Guide Thermo Scientific MSO Plus Mass Detector Preinstallation Guide xiii Preface Safety and Special Notices Dionex MSQ Plus Facilities Preinstallation Requirements Guide Dionex MSQ Hardware Manual Dionex Installation and Commissioning Guide Dionex MSQ Preventive Maintenance Dionex MSQIOLA Nitrogen Generator
20. atography LC system requires large and strong workbenches You must install a telephone within reach of the workbench See Table 1 for a summary of site preparation requirements and see the pages indicated in the table for details Table 1 Site preparation requirements Requirement Page Entrance 4 For the system to be delivered to the site your entrances and hallways must be a minimum of 70 cm 28 in wide for passage of the instrument Space and Load Requirements 4 The total workbench surface must have minimum dimensions of 0 9 x 2m 3 x 6 ft to support the MSQ Plus Mass Detector the Accela LC system the optional cone wash pump and the data system with user supplied printer The workbench surface must be capable of supporting the weight of the MSQ Plus Mass Detector 60 kg 132 Ibs and the data system with printer 39 kg 86 lbs plus the weight of your liquid chromatograph and any options Telephone 7 A telephone line must be installed near the workbench Thermo Scientific MSQ Plus Mass Detector Preinstallation Guide 3 2 Site Preparation Entrance You are responsible for providing an acceptable installation site IMPORTANT The MSQ Plus Mass Detector must be located within 2 5 m ofa connection to an external laboratory vent Entrance The entrance to your facility and the width of all hallways elevators and so on must be a minimum of 70 cm 28 in However you must also allow additional room for
21. dsstaaten getroffen damit dieses Produkt durch diese Firmen wiederverwertet oder entsorgt werden kann Mehr Information ber die Einhaltung dieser Anweisungen durch Thermo Fisher Scientific ber die Verwerter und weitere Hinweise die n tzlich sind um die Produkte zu identifizieren die unter diese RoHS Anweisung fallen finden sie unter www thermoscientific com rohsweee Thermo SCIENTIFIC Conformite DEEE Ce produit doit tre conforme la directive europ enne 2002 96 EC des D chets d Equipements Electriques et Electroniques DEEE Il est marqu par le symbole suivant Thermo Fisher Scientific s est associ avec une ou plusieurs compagnies de recyclage dans chaque tat membre de l union europ enne et ce produit devrait tre collect ou recycl par celles ci Davantage d informations sur la conformit de Thermo Fisher Scientific ces directives les recycleurs dans votre pays et les informations sur les produits Thermo Fisher Scientific qui peuvent aider la d tection des substances sujettes la directive RoHS sont disponibles sur www thermoscientific com rohsweee Contents Thermo Scientific Chapter 1 Chapter 2 Chapter 3 Chapter 4 Chapter 5 A ee a n ARR RU ir abge xiii Belated Documentitian een dit ls er lastra dee xiii Safety and Special Notices unse vid p ER RE ere dard xiv SUED PESOS acr Ds oci one AAA LEAS Er CE E bx Fd xv Contacting US un Yan np xvi Introduction end 1 Site Preparation A
22. e and in this instance any damage incurred in shipment is the responsibility of the purchaser and the carrier However Thermo Fisher Scientific San Jose assists with claims filing and billable repairs if necessary If the system is shipped FOB destination Thermo Fisher Scientific San Jose will file a claim against the carrier Note Thermo Fisher Scientific San Jose does not accept liability for damage if materials are received with obvious damage and the damage is not recorded on the receiving documents When your system arrives move it to a protected location indoors If you have questions about moving your system contact your local office for Thermo Scientific products Telephone and fax numbers for the offices are listed in the Preface on page xiii of this guide International Shipments Instruments shipped outside of the United States are shipped CIP carriage and insurance paid to destination unless specified differently If the system is shipped CIP destination and if any damages are incurred in shipment Thermo Fisher Scientific San Jose will file a claim against the carrier Note Thermo Fisher Scientific San Jose does not accept liability for damage if materials are received with obvious damage and the damage is not recorded on the receiving documents 38 MSO Plus Mass Detector Preinstallation Guide Thermo Scientific Installation Thermo Scientific This chapter describes the requirements that must
23. e MSQ Plus Mass Detector and the data system Table 8 and Table 9 show examples of how to balance the power load among three wall outlets without exceeding their specifications See Figure 1 on page 5 for a typical installation The specifications for the modules in your system might vary from those in this guide The power specifications on the module always supersede those in the guide Table 8 Suggested power connections for an MSQ Plus Mass Detector at 230 Vac an LC at 120 Vac and the data system with printer at 120 Vac Sheet 1 of 2 Fourplex outlet 1 Fourplex outlet 2 Fourplex outlet 3 120 Vac 230 Vac 120 Vac MSQ Plus Mass Detector 3A Module Liquid chromatograph 10 A Cone wash pump optional Nitrogen generator optional 4A Monitor 2A Computer 4A MSQ Plus Mass Detector Preinstallation Guide 23 4 Line Power Uninterruptible Power Supply Table 8 Suggested power connections for an MSQ Plus Mass Detector at 230 Vac an LC at 120 Vac and the data system with printer at 120 Vac Sheet 2 of 2 Module Fourplex outlet 1 Fourplex outlet 2 Fourplex outlet 3 120 Vac 230 Vac 120 Vac Laser printer 3A Total 10 A 7A 9A Approximate The actual value depends on your equipment Table 9 Suggested power connections for an MSQ Plus Mass Detector an LC and the data system at 230 Vac Fourplex outlet 1 Fourplex outlet i2 Fourplex outlet 3 Dar 230 Vac 230
24. e care when handling the corona pin The corona pin is sharp and can cause personal injury Take care when removing or installing the corona pin CAUTION Make sure you have sufficient nitrogen for your API source Before you begin normal operation each day make sure that you have sufficient nitrogen for your API gt gt PRP bb source The presence of atmospheric oxygen in the API source when the mass detector is on could be unsafe Thermo Scientific MSQ Plus Mass Detector Preinstallation Guide XV Preface Contacting Us CAUTION Contain waste streams Because the API source can accommodate high solvent flow rates you must make provisions to collect the waste solvent CAUTION Provide adequate fume exhaust systems for the API source solvent waste container and the forepump Your laboratory must be equipped with at least two fume exhaust systems one to vent the waste container connected to the exhaust port API solvent drain on the back of the mass detector and the other to vent the forepump exhaust As described in the MSQ Plus Mass Detector Getting Connected Guide route the blue forepump exhaust hose to a dedicated fume exhaust system Because the exhaust hose acts as a trap for exhaust fumes that would otherwise recondense in the forepump oil the hose should travel at floor level for a minimum of two meters 78 5 in before it reaches the external exhaust system Route tubing from the waste container connected to the exhaust port on t
25. e or mishandling then you can proceed with the instructions that follow 4 MSQ Plus Mass Detector Preinstallation Guide Thermo Scientific 2 Site Preparation Space and Load Requirements Figure 1 Space requirements for your MSQ Plus Mass Detector system Accela LC system 36 cm 14 in MSQ Plus Mass Detector Data system 30 cm computer 19 cm Monitor 7 in 114 cm User supplied 45 in gt printer 41 cm To vent for 16 in forepump exhaust T6 cm To vent 30in El al Solvent Waste container Fourplex wall outlet 1 Forepump Fourplex Nitrogen Fourplex wall outlet 3 trap for LC system 115 Vac or 230 Vac with oil wall outlet 42 generator 115 Vac or 230 Vac mist filter 230 Vac Table 2 Space requirements and weights of system components Sheet 1 of 2 Height Width Depth Weight Module cm in cm in cm in kg Ib MSQ Plus Mass 55 22 30 12 70 28 60 132 Detector Accela LC system 114 45 36 142 51 20 68 150 Cone wash pump 159 6 25 197 775 35 6 14 2 7 15 Mid tower 48 19 18 7 43 17 23 50 computer Monitor 41 16 41 16 20 8 10 22 Keyboard 3 2 48 19 20 8 1 2 Thermo Scientific MSQ Plus Mass Detector Preinstallation Guide 5 2 Site Preparation Space and Load Requirements Table 2 Space requirements and weights of system components Sheet 2 of 2 Height Width Depth Weight Mod
26. gen generators require an air compressor Some air compressor models are quite noisy so be careful to select a quiet compressor The generator provides a continuous source of nitrogen it needs no replacement but requires annual maintenance of the generator Thermo Fisher Scientific recommends using Peak Scientific field service for annual maintenance Solvent Recommendations The solvents listed in Table 12 are useful in operating and maintaining the MSQ Plus Mass Detector Installation of the MSQ Plus Mass Detector requires HPLC grade methanol and water Solvent modifiers might also be required during the installation of some systems Thermo Scientific MSQ Plus Mass Detector Preinstallation Guide 29 5 Gases and Solvents Solvent Recommendations Note Some solvent impurities are transparent to UV Vis detectors Therefore some HPLC grade solvents might contain contaminants that interfere with the performance of the MSQ Plus Mass Detector For operation of your MSQ Plus Mass Detector choose high purity solvents with minimum contamination Table 12 Solvents and reagents and modifiers Solvents Reagent Specifications Methanol HPLC grade Acetonitrile HPLC grade Water HPLC grade Isopropyl alcohol HPLC grade Ammonium acetate A C S reagent Acetic acid modifier A C S reagent Note 1 Do not filter solvents Filtering solvents can introduce contamination 2 Thermo Fisher Scientific recommends Fisher Chemical
27. hat you monitor the power line 24 hours a day for seven consecutive days before connecting your MSQ Plus Mass Detector to line power Power Conditioning Devices 19 To free line power from voltage changes sags surges and transients the following devices are available Noise suppression transformer Buck boost transformer Power conditioning 16 MSQ Plus Mass Detector Preinstallation Guide Thermo Scientific 4 Line Power Table 5 Summary of line power preinstallation requirements Sheet 2 of 2 Requirement Page Available Outlets 19 For systems installed where there is 110 and 230 V e Nominal voltage of 120 Vac 6 to 21096 and 230 Vac 10 and free from voltage variations above or below this operating range Frequency of 50 60 Hz Two fourplex outlets eight single phase power receptacles with a minimum power rating of 20 A 120 Vac Onefourplex outlet four single phase power receptacles with a minimum power rating of 16 A 230 Vac Thermo Fisher Scientific recommends the NEMA 6 15B shown in Figure 3 Earth ground hard wired to the main panel For systems with only 230 V line power Nominal voltage of 230 Vac 10 Note For systems installed in areas with 208 Vac nominal line power you must use a buck boost transformer to keep your line power within operating parameters Frequency of 50 60 Hz Three fourplex outlets twelve power receptacles with a minimum power rating of 16 A at each fo
28. he back of the mass detector to a second dedicated fume exhaust system Consult local regulations for the proper method of exhausting the fumes from your system Do not vent the PVC drain tube or any vent tubing connected to the waste container to the same fume exhaust system that is connected to the forepump The forepump exhaust contains pump oil which can seriously contaminate the analyzer optics of the mass spectrometer Contacting Us There are several ways to contact Thermo Fisher Scientific for the information you need To contact Technical Support Phone 800 532 4752 Fax 561 688 8736 E mail us techsupport analyze thermofisher com Knowledge base www thermokb com Find software updates and utilities to download at mssupport thermo com To contact Customer Service for ordering information Phone 800 532 4752 Fax 561 688 8731 E mail us customer support analyze thermofisher com Web site www thermo com ms Xvi MSQ Plus Mass Detector Preinstallation Guide Thermo Scientific Thermo Scientific Preface Contacting Us To get local contact information for sales or service Go to www thermoscientific com wps portal ts contactus To copy manuals from the Internet Go to mssupport thermo com agree to the Terms and Conditions and then click Customer Manuals in the left margin of the window To suggest changes to documentation or to Help Fill out a reader survey online at www surveymonkey com s PQM6P62 Send an e m
29. he forepump and for connecting the vacuum hose from the MSQ Plus Mass Detector to the forepump Ifthe workbench has space beneath it place the forepump on the floor under the workbench immediately behind the MSQ Plus Mass Detector as shown in Figure on page 5 Either run the vacuum hose behind the workbench or make a 6 4 cm 2 5 in diameter hole through the bench for the vacuum hose Allow for room to run the power cords from the forepump through the hole Ifthe workbench has no space under or at the end of it place the forepump on the floor in front of the MSQ Plus Mass Detector CAUTION Whenever possible provide space under the workbench for the forepump If placed in front of the MSQ Plus Mass Detector the forepump can block access to drawers and cabinets and can represent a trip hazard Note To maintain forepump integrity route the exhaust tubing from the exhaust port down to the floor not from the forepump vertically toward the ceiling 3An Accela LC system containing a pump an autosampler and a PDA weighs approximately 65 kg 143 Ibs Add more weight for the solvent platform which holds the solvent reservoir bottles filled with solvent 6 MSQ Plus Mass Detector Preinstallation Guide Thermo Scientific Telephone Thermo Scientific 2 Site Preparation Telephone If you are using the N418LA nitrogen generator shown in Figure 2 install it on the floor close to the MSQ Plus Mass Detector Because the gas
30. he instrument is installed can affect performance The laboratory room temperature must be maintained between 15 and 35 C 59 and 95 F Also make sure that the temperature does not fluctuate by more than 10 C 50 F to ensure good mass accuracy Note As the laboratory temperature increases system reliability decreases All electronic components generate heat while operating This heat must be dissipated to the surrounding air for the components to continue to operate reliably There must be a good flow of room air around the system and the air conditioning system must be capable of maintaining a constant temperature in the immediate vicinity of the system Note Do not place the MSQ Plus Mass Detector under an air duct near windows or near heating and cooling sources Temperature fluctuations of 5 C or more over a 5 minute period of time can affect performance The air conditioning load for an MSQ Plus Mass Detector with an Accela LC and a data system is approximately 5000 W 17000 Btu h Refer to your Accela LC manual for the heat output of your LC equipment 10 MSO Plus Mass Detector Preinstallation Guide Thermo Scientific Humidity Vibration Lighting Thermo Scientific 3 Operating Environment Humidity Table 4 shows the approximate heat output of each module Table 4 Heat output for the MSO Plus Mass Detector an LC and the data system with printer Module IM TS MSQ Plus Mas
31. he power on The MSQ Plus Mass Detector should remain on and pumping continuously for optimum performance 2 Additional power outlets might be required for test and cleaning equipment such as an oscilloscope and ultrasonic bath Thermo Fisher Scientific recommends that there be several additional power outlets close to the workbench space within your laboratory Figure 1 on page 5 shows the optimum location of the power outlets The power cable from the MSQ Plus Mass Detector and the cables from the personal computer monitor and printer are approximately 2 m 6 ft long The MSQ Plus Mass Detector ships with a plug appropriate to its shipping destination The data system ships with a NEMA 6 15P plug which is rated at 15 A and 125 Vac Local codes in your area might require that another type of plug and receptacle be installed The Thermo Fisher Scientific field service engineer for your country will provide the appropriate power plugs Note Do not use the NEMA 5 15P plug The NEMA plugs and their corresponding outlets are shown in Figure 4 Figure 4 NEMA 6 15P and NEMA 5 15P power plugs and their respective outlets NEMA 6 15P Outlet Plug Outlet Plug Table 6 shows the maximum current required by each component of a typical MSQ Plus Mass Detector The MSQ Plus Mass Detector operates with 230 Vac only The optional N418LA nitrogen generator also requires a 230 Vac power source You can manually set other component
32. l vapor that these pumps characteristically emit Therefore connect the forepump to a fume exhaust system Note An efficient fume exhaust system is required for the proper operation of the forepump Most API applications contribute to the accumulation of solvents in the forepump These solvents must be purged from the mechanical pump oil periodically by opening the ballast valve located on the top of the pump When the ballast valve is opened a large volume of volatile solvent waste might enter the fume exhaust system Therefore your fume exhaust system must be able to accommodate the periodic purging of the solvents The frequency of the purging depends on the throughput of your system The forepump has two functions Providing a vacuum for the capillary skimmer of the API source Providing backing pressure for the turbomolecular pump Consult local regulations for the proper method of exhausting the fumes from your system There are two exhaust lines to consider Forepump Exhaust e Electrospray APCI Exhaust CAUTION You laboratory must contain an appropriate exhaust system The lack of an appropriate exhaust system can lead to personal injury Forepump Exhaust Vent the exhaust line from the forepump to the atmosphere external to the laboratory through a user supplied fume hood or industrial vent exclusive to the forepump as shown in Figure 7 32 MSO Plus Mass Detector Preinstallation Guide Thermo Scientific 6 Was
33. lation Guide 11 3 Operating Environment Particulate Matter Particulate Matter The air in your laboratory must not have excessive dust smoke or other particulate matter For reference the air should contain fewer than 100000 particles per cubic foot 3500000 particles per cubic meter in excess of 5 um Dust can clog the air filters causing a reduction in air flow around electronic components Dust can also form a layer on electronic components that acts as an insulating blanket and reduces the transfer of heat from the components to the surrounding air Electrostatic Discharge Electrostatic discharge ESD can damage the electronic components of your MSQ Plus Mass Detector The MSQ Plus Mass Detector can withstand electrostatic discharges ESD up to 8 kV air discharge and 4 kV contact discharge with all panels in place However if the panels are removed and the PCBs are handled without proper precautions the electronic components might be damaged or fail prematurely Static electricity can develop in a variety of ways A few examples of how electrostatic charge can develop are as follows When walking across a carpet in a room that is at 20 relative humidity as much as 35000 V of electrostatic potential can be generated on the surface of your body A similar trip in a room at 80 relative humidity generates about 1500 V of electrostatic potential Sitting and working in a chair padded with polyurethane foam in a room
34. lts with durations of up to 50 us Constant high line voltage impulses or surges in voltage can cause overheating and component failures Constant low line voltage or sags in voltage can cause the system to function erratically or not at all Transients even a few microseconds in duration can cause electronic devices to fail catastrophically or to degrade and eventually shorten the lifetime of your system Therefore it is important to establish the quality of the line voltage in your laboratory before installing your MSQ Plus Mass Detector Power Monitoring Devices A variety of devices are available to monitor the quality of your line power These devices provide a continuous record of line performance by analyzing and printing out information on three types of voltage disturbances Slow average e Sag and surge Transient 18 MSO Plus Mass Detector Preinstallation Guide Thermo Scientific 4 Line Power Power Conditioning Devices In the first two cases the duration as well as the amplitude of the disturbance are indicated by time interval recording The Dranetz power line disturbance analyzer is a device capable of detecting and recording most types of line power problems Line monitors can be rented from electrical equipment suppliers Monitor the power line 24 hours a day for seven consecutive days If inspection of the printout indicates disturbances terminate the test and take corrective action Then monitor the powe
35. must be of high purity 99 The required gas pressure is 520 140 kPa 75 psi Note To calibrate the MSQ Plus Mass Detector nitrogen gas proportioning valves a nitrogen gas regulator must be available that can be adjusted from 0 to 690 kPa 0 to 100 psi Run the nitrogen gas line to the back of the MSQ Plus Mass Detector Terminate the nitrogen gas supply line with the half union 6 mm 1 4 BSP If you are connecting to the N418LA nitrogen generator limit the nitrogen gas supply line to 6 m 20 ft Particulate filters can be a source of contamination Thermo Fisher Scientific does not recommend them Typical nitrogen gas consumption is approximately 12 L per minute in ESI mode and 8 L per minute in APCI mode On the basis of a 24 hour day maximum usage can be up to 15800 L 560 ft per day so Thermo Fisher Scientific recommends that nitrogen be supplied from one of the following sources A large sealed thermally insulated cylinder containing liquid nitrogen from which the nitrogen gas is boiled off Thermo Fisher Scientific recommends the 230 psi model The 35 and 80 psi models do not provide sufficient gas pressure A typical cylinder of size 240 L yields 143 850 L 5080 ft of gas Note Liquid nitrogen conversion factors 1 0 lb of liquid nitrogen 0 5612 L 1 0 kg of liquid nitrogen 1 237 L A nitrogen generator with a minimum capacity of 12 L per min at 99 purity with 75 to 80 psi at the side panel Nitro
36. n Norway and Finland Spain C Valportillo I n 22 1a Planta Edificio Caoba ES 28108 Alcobendas Madrid E mail service sid spain thermofisher com Phone 34 914 845 965 O ET 34 914 843 598 Notes The country code is enclosed in square brackets The city code or area code is enclosed in parenthesis For countries other than the U S when you are dialing from within the specified country dial the O of the city code For countries other than Italy when you are dialing from outside the country do not dial the O of the city code Chromatography and Mass Spectrometry Offices Continued Europe continued Sweden Norway and Finland Pyramidbacken 3 S 141 75 Kungens Kurva Stockholm Sweden E mail service sid nordic thermofisher com PRONE 46 0 8 556 468 20 Fax en 46 0 8 556 468 08 Switzerland Neuhofstrasse 11 4153 Reinach E mail service sid ch thermofisher com Phone 41 617 16 77 40 Fax 41 617 16 77 20 United Kingdom Stafford House 1 Boundary Park Boundary Way Hemel Hempstead Hertfordshire HP2 7GE E mail service sid hemel thermofisher com Phone 44 0 870 241 1034 FAX 44 0 1442 233 667 Australasia and Asia Australia P O Box 9092 5 Caribbean Drive Scoresby VIC 3179 E mail analyze au thermofisher com Phone 61 39757 4300 Fate 61 9763 1169 Japan C 2F 3 9 Moriya cho Ka
37. nagawa ku Yokohama 221 0022 E mail analyze jp thermofisher com Phone 81 45 453 9100 Fax user 81 45 453 9110 P R China 7 F Building F Tower West Younghe Plaza No 28 Andingmen East Street Dong Cheng District Beijing 100007 E mail analyze cn thermofisher com Phone 24 86 010 8419 3588 FAX qu 86 010 8419 3589 Regulatory Compliance Thermo Fisher Scientific performs complete testing and evaluation of its products to ensure full compliance with applicable domestic and international regulations When the system is delivered to you it meets all pertinent electromagnetic compatibility EMC and safety standards as described in the next section or sections by product name Changes that you make to your system may void compliance with one or more of these EMC and safety standards Changes to your system include replacing a part or adding components options or peripherals not specifically authorized and qualified by Thermo Fisher Scientific To ensure continued compliance with EMC and safety standards replacement parts and additional components options and peripherals must be ordered from Thermo Fisher Scientific or one of its authorized representatives EMC Directive 89 336 EEC as amended by 92 31 EEC and 93 68 EEC EMC compliance has been evaluated by UNDERWRITERS LABORATORY INC UL EN 55011 1998 EN 61000 4 3 2002 EN 61326 1 1998 EN 61000 4 4 2001 EN 61000 3 2 1995 EN 61000 4 5 2001 EN 61000 3
38. nce is essential It increases the life of the system maximizes the uptime of your system and provides you with optimum system performance For maintenance procedures consult the following manuals MSQ Plus Mass Detector Hardware Manual Manuals that come with your data system computer and other modules of your system 42 MSO Plus Mass Detector Preinstallation Guide Thermo Scientific Index A Accela LC system 3 acetic acid 30 acetonitrile 30 41 air conditioning 10 40 ammonium acetate 30 ammonium hydroxide 41 APCI probes 42 auxiliary gas 29 buck boost transformers 16 19 C calibrant 42 chemical kits 41 compliance FCC vii regulatory vii compliance WEEE ix cone wash pumps 3 contacting us xvi damage 37 documentation survey xvii domestic shipments of instruments 37 doorways 3 4 40 dust 12 E Edwards rotary pumps 42 electrical connections 6 electrical outlets 17 19 23 41 electromagnetic compatibility vii Thermo Scientific electrostatic discharge 10 12 41 ESI probes 42 exhaust systems APCI 34 ESI 34 forepumps 32 separate from solvent waste 41 venting 51 F FCC compliance vii field service engineers 42 floor area 40 flooring 40 forepumps connecting vacuum hose 6 exhaust system 32 function of 32 placing 6 freight insurance 37 G gas and solvent requirements fittings and parts 27 28 gases 27 solvents 27 gas lines 6 gases auxiliary 29 contaminants 29 nitrogen 2
39. nts Thermo Scientific This chapter describes the requirements for delivering gas and solvents to the MSQ Plus Mass Detector Contents Fittings and Parts Gases Solvent Recommendations Your instrument requires high purity nitrogen gas and HPLC solvents The service engineer might also require certain solvents for the installation verification of your system Table 10 summarizes the gas and solvent requirements More information on each of the requirements is available on the page indicated in the table Table 10 Summary of solvent and gas preinstallation requirements Requirement Page Fittings and Parts 28 It is your responsibility to supply all fittings and parts necessary for connecting gases during the installation of your system The tubing for the nitrogen supply to the MSQ Plus Mass Detector is 6 mm OD PTFE The installation kit for the MSQ Plus Mass Detector includes a 6 mm x 1 4 in BSP half union fitting which allows connection to 1 4 in swaged connections in typical U S laboratories Gases 28 High purity 99 The required gas pressure is 520 kPa 75 psi Solvent Recommendations 29 Some solvents modifiers might be necessary for the installation of your system MSQ Plus Mass Detector Preinstallation Guide 2 5 Gases and Solvents Fittings and Parts Fittings and Parts Table 11 lists the minimum parts that are required to connect your MSQ Plus Mass Detector to your gas delivery system Y
40. o Scientific MSQ Plus Mass Detector Preinstallation Guide 35 Instrument Arrival The MSQ Plus Mass Detector is shipped by electronic equipment carriers that specialize in the handling of delicate machinery Occasionally however equipment inadvertently does get damaged in transit Contents Receiving Material Domestic Shipments International Shipments Receiving Material Please take the following precautions when receiving material Check carefully for obvious damage or evidence of rough handling Ifexternal damage is apparent note this fact on all copies of the receiving documents and briefly describe the extent of the damage The driver should sign or initial next to your comments to signify agreement with your observations Contact the Traffic Department telephone 1 408 965 6000 at the Thermo Fisher Scientific office in San Jose California U S to report the damage Note Freight insurance requires that obvious damage be noted on the receiving documents Domestic Shipments Instruments are shipped domestically using one of the following methods FOB free on board San Jose California U S e FOB destination Thermo Scientific MSQ Plus Mass Detector Preinstallation Guide 37 7 Instrument Arrival International Shipments The method of shipment determines who has responsibility for filing a claim against the carrier if the system is damaged in transit Most systems are shipped FOB San Jos
41. ooring will support the load 4 Sufficient bench space is available for all of the equipment List the following Width Depth Height 5 The workbench can support the load of the mass spectrometer LC system and data system 170 kg 370 Ibs and is free from vibration 6 One voice telephone line is installed near the system 7 Air conditioning is adequate for temperature humidity and particulate matter control The laboratory can be maintained at a constant temperature between 15 and 35 C 59 and 95 F oo Relative humidity is between 40 and 8096 with no condensation 40 MSO Plus Mass Detector Preinstallation Guide Thermo Scientific 10 11 12 13 14 15 16 17 18 19 20 21 22 23 8 Installation Installation Kits and Components Lighting is adequate System work area is free from magnetic disruption and electrostatic discharge Main power is installed and complies with local electrical codes Power for test and cleaning equipment is installed Power outlets are of the NEMA 6 15P configuration Note NEMA type Voltage of power outlet has been measured Note the measured voltage Power is free from fluctuations due to slow changes in the average voltage or changes due to surges sags or transients The required nitrogen gas is on site gas lines are installed and appropriate gas regulators are available In addition an adapter for connecting to 6 mm OD PTFE tubing i
42. ot perform any servicing other than that contained in the MSQ Plus Mass Detector Hardware Manual To avoid personal injury or damage to the instrument do not perform any servicing other than that contained in the MSQ Plus Mass Detector Hardware Manual or related manuals unless you are qualified to do so CAUTION Shut down the mass detector and disconnect it from line power before you service it High voltages capable of causing personal injury are used in the instrument Some maintenance procedures require that the mass detector be shut down and disconnected from line power before service is performed Do not operate the mass detector with the top or side covers off Do not remove protective covers from PCBs CAUTION Do not interfere with the safety interlock Interfering with the safety interlock will expose you to potentially lethal electrical hazards CAUTION Respect heated zones Treat heated zones with respect The ion transfer capillary and the APCI vaporizer might be very hot and might cause severe burns if touched Allow heated components to cool before you service them CAUTION Place the mass detector in Standby or Off mode before you open the atmospheric pressure ionization API source The presence of atmospheric oxygen in the API source when the mass detector is on could be unsafe The mass detector automatically goes into standby mode when you open the API source however take this added precaution for safety reasons CAUTION Tak
43. our connections and gas delivery system might vary and you are responsible for supplying any fittings or connections necessary during installation Table 11 Gas connection hardware required Description Quantity 6 mm OD x 1 4 NPT PTFE nitrogen supply tubing 2 m 6 ft provided You might shown in Figure 5 The Swagelok connector for the 1 4 require additional length NPT fitting shown in Figure 6 is also included Nitrogen regulator adapter half union 6 mm 1 4 BSP 1 Connection for the opposite end of the Teflon hose to Not provided in kit You supply the nitrogen gas source this part British Standard Pipe Figure b NPT PTFE nitrogen supply tubing part number 00103 02 00001 Figure 6 Swagelok tube fitting part number 00101 02 00006 Gases Your system can use large amounts of nitrogen gas during daily operations It is essential that the nitrogen gas be delivered with the necessary pressure and purity 28 MSQ Plus Mass Detector Preinstallation Guide Thermo Scientific 5 Gases and Solvents Solvent Recommendations CAUTION Contaminants introduced during the installation of house lines used for gas delivery can cause damage to the system Ensure that all gas lines used with your system have been cleaned of all particulates and oils You are responsible for any damage to the instrument caused by contaminates introduced from your gas delivery system The nitrogen for the API sheath gas and auxiliary gas
44. place Styrofoam cups or packing materials on the instrument Thermo Scientific MSQ Plus Mass Detector Preinstallation Guide 13 Line Power This chapter describes the line power requirements of the MSQ Plus Mass Detector Contents Quality of Power Power Monitoring Devices Power Conditioning Devices Available Outlets Connecting the MS LC and Other Modules to Wall Oudets Uninterruptible Power Supply Technical Assistance The performance and longevity of your system can be affected by the quality of line power delivered to the system To ensure that your instrument performs optimally and is not damaged by line power fluctuations verify that you comply with all power quality requirements See Table 5 for a summary of line power requirements More information on each of the requirements is available on the page indicated in the table Thermo Scientific MSQ Plus Mass Detector Preinstallation Guide 15 4 Line Power Table 5 Summary of line power preinstallation requirements Sheet 1 of 2 Requirement Page Quality of Power 18 Line power must be free from Long term changes in average root mean square RMS voltage level with durations greater than 2 s Sudden changes in average RMS voltage level with durations between 50 ms and 2 s Brief voltage excursions of up to several thousand volts with durations of up to 50 us Power Monitoring Devices 18 Thermo Fisher Scientific strongly recommends t
45. pump connection fittings In addition to these kits these components are shipped with the mass detector USB cable part number 00302 99 00008 Solvent trap assembly part number FM103894 Edwards rotary pump oil part number 00301 15102 ESI probe part number FM102595 This probe comes installed e APCI probe part number FM102587 This probe ships in a separate box To inject calibrant you must connect an LC pump to your MSQ Plus Mass Detector To inject samples you must connect an LC pump and injection device Note You are responsible for replacing any consumables used during the installation Installation When your new MSQ Plus Mass Detector is on site and ready for installation a Thermo Fisher Scientific field service engineer will install it During the installation the field service engineer demonstrates the following The basics of equipment operation and routine maintenance The marketing specifications that are in force at the time of the purchase of the system Note To receive maximum benefit from this on site training opportunity the instrument s operators must be available during the entire installation Do not plan to use your new system for sample analysis until the installation is complete and you have signed the acceptance form Preventive Maintenance Routine and preventive maintenance of the MSQ Plus Mass Detector and data system is your responsibility Regular preventive maintena
46. r again as just described Power Conditioning Devices Various line voltage conditioning devices are available that can correct your line voltage problem If you have good regulation but the power line disturbance analyzer shows transient voltages an isolation noise suppression transformer should be adequate to resolve the problem If there are both transient and regulation problems consider power conditioners which can control both of these problems CAUTION Any conditioning devices installed with your system must be able to deal with the potentially high currents that are drawn during the initial startup of the system For example the forepump can draw as much as 30 A during startup Contact your service engineer for more information When the line voltage is free from voltage sags surges and impulses but is more than 10 outside of the voltage specifications you can lower the line voltage bucked 10 or raise it boosted 10 by using a buck boost transformer You can order the buck boost transformer kit P N OPTON 01460 from Thermo Fisher Scientific Each buck boost transformer is encased in a metal housing approximately 13 x 13 x 26 cm 5 x 5 x 10 in and is equipped with a 2 m 6 ft power cable The installation instructions for the transformer are included Only an electrician can install the transformer Have the electrician install the buck boost transformer before you start the installation of your system CAUTION To suppo
47. rt compliance and safety requirements ensure that your power conditioning devices are certified by recognized domestic and international organizations such as UL CSA TUV and VDE Available Outlets Thermo Scientific The MSQ Plus Mass Detector operates at a nominal voltage of 230 Vac 50 60 Hz Line voltages can vary between a minimum of 207 Vac and a maximum of 253 Vac 1 Thermo Fisher Scientific does not endorse any power monitoring company nor does it endorse products other than its own Companies and products listed in this guide are given as examples only MSQ Plus Mass Detector Preinstallation Guide 19 4 Line Power Available Outlets CAUTION Systems installed in areas with 208 V power will experience voltage sags during high use periods that might place the line voltage below the operating parameters discussed in this section In that case you must protect your instrument by using a buck boost transformer to ensure that power is within the specified parameters at all times The minimum and maximum voltage tolerances are in compliance with IEC 950 Amend 2 1993 paragraph 1 6 5 as follows Equipment intended to operate directly from the main supply shall be designed for a minimum supply tolerance of 6 and 10 If the rated voltage is 230 Vac single phase or 400 Vac three phase the equipment shall operate safely within a minimum supply tolerance of 10 For systems installed in regions with both 120 Vac and 23
48. s installed on the nitrogen supply line These adapters are included in the installation kit List the purity of the nitrogen gas supply New or recently cleaned HPLC system is available that produces pulse free continuous flow from 50 to 2000 uL min HPLC grade water methanol acetonitrile ammonium hydroxide and isopropyl alcohol are available for testing your instrument There is a suitable exhaust system present that is separate from solvent waste Provision has been made for collecting solvent waste from API source All relevant safety regulations are complied with Your MSQ Plus Mass Detector is on site The principal operator will be available during the installation or certification period Installation Kits and Components The following kits are shipped with the MSQ Plus Mass Detector Thermo Scientific Installation kit which contains the cables connectors and adapters required to install the MSQ Plus Mass Detector Media kit which contains software and MSQ instrument driver CDs MSQ Tool kit which contains the tools required to install and maintain the mass detector system Chemical kit which contains the necessary chemicals for demonstrating system y y performance specifications and for performing instrument tune and mass calibration MSQ Plus Mass Detector Preinstallation Guide 41 8 Installation Installation Mechanical pump kit which contains the oil mist filter kit the drain oil return kit and the
49. s Detector with forepump 3000 10200 Accela liquid chromatograph 870 3000 Monitor 240 820 Computer 470 1600 Laser printer 350 1200 Total 4930 16820 Approximate The actual values depend on your equipment The relative humidity of the operating environment must be between 40 and 80 with no condensation Relative humidity must not exceed 80 for temperatures up to 31 C 87 8 F decreasing linearly to 50 relative humidity at 35 C 95 F Operating a MSQ Plus Mass Detector in an environment with very low humidity can cause the accumulation and discharge of static electricity which can shorten the life of the electronic components Operating the system in an environment with high humidity can cause condensation oxidation and short circuits It can also cause the accumulation of dust that can block filters on cooling fans To ensure that your laboratory is always within the required temperature and humidity specifications equip your laboratory with a temperature and humidity monitor Floors must be free of vibration caused for example by equipment in adjoining locations Because of the natural vibration of the forepump during operation install it on the floor beneath the MSQ Plus Mass Detector not near the system on the workbench Good lighting makes any work area more enjoyable Thermo Fisher Scientific recommends a small high intensity lamp for cleaning the mass spectrometer components MSQ Plus Mass Detector Preinstal
50. s to 120 Vac or 230 Vac or you can order them as a 120 Vac or 230 Vac option MSQ Plus Mass Detector Preinstallation Guide 21 4 Line Power Available Outlets CAUTION The values listed in Table 6 are the average currents drawn by each of the listed components Any conditioning devices installed with your system must also be able to deal with the potentially high currents drawn during the initial startup of the system For example the forepump can draw as much as 30 A during startup For more details on the surge requirements for your system consult the forepump manuals Contact your service engineer for more information Installing a conditioning device incapable of handling the potentially high currents drawn during the initial startup of the system could lead to personal injury Table 6 Maximum current single phase for a MSQ Plus Mass Detector at 230 Vac an LC at 120 or 230 Vac and the data system with printer at 120 or 230 Vac Voltage 120 Vac current Voltage 230 Vac current MOIS in amperes in amperes MSQ Plus Mass Detector NA 3 230 V only Forepump NA 10 Nitrogen generator N418LA NA 4 Liquid chromatograph 10 5 Monitor 2 1 Computer 4 2 Laser printer 2 2 Approximate The actual value depends on your equipment Note Refer to your LC equipment manual for power requirements and specifications Installation of a complete LC MS system can require extensive electrical resources To plan
51. te and Exhaust Exhaust System Figure 7 Forepump exhaust system using oil mist filter USER O E m cem lel manson ND oo EXE m a Lr 2 To user supplied vent MAINS IN for exhaust fumes Pulls rough vacuum in a ss source chamber Pulls rough vacuum for turbomolecular poe Bump UUUU Oil mist NNMAN filter E mj le D 49 177 EDWARDS 30 El O Edwards forepump Thermo Scientific MSQ Plus Mass Detector Preinstallation Guide 33 6 Waste and Exhaust Exhaust System Electrospray APCI Exhaust Figure 8 Source compartment exhaust system for the MSQ Plus Mass Detector Connect the exhaust line that connects the drain at the bottom of the source compartment to the exhaust port on the back panel of the MSQ Plus Mass Detector to a solvent trap Vent the solvent trap to the atmosphere external to the laboratory During installation a Thermo Fisher Scientific field service engineer will connect the solvent trap to a user supplied fume hood or industrial vent by using the 2 5 m x 19 mm ID tubing supplied with the system as shown in Figure 8 CAUTION Serious damage to the instrument as well as personal injury might occur if the ESI APCI exhaust line is connected to the forepump exhaust line MSQ Plus Mass Detector 34 SOURCE
52. tion of your system MSQ Plus Mass Detector Preinstallation Guide 39 8 Installation Preinstallation Survey Table 14 More information on the installation of your system Sheet 2 of 2 Requirement Page Installation 42 The service engineer completes the installation of the system and demonstrates that your system meets specifications Do not plan to use the system before the engineer has demonstrated that your system operates within specifications Preventive Maintenance 42 You are responsible for the proper maintenance of your system Preinstallation Survey Verify that your laboratory meets the following list of preinstallation requirements before your instrument is installed Use the MSQ Plus Mass Detector Installation Request Form at the front of this guide to check off each item as it is completed or verified Note Your instrument is shipped in a shipping container the smallest dimension of which is 70 cm 28 in If the entrance to your laboratory will not accommodate a 70 cm container you can remove the individual modules from the container before moving them into the room If you remove the instrument from its shipping container before it is delivered to the lab site be sure that all the contents of the container remain with the instrument 1 All laboratory remodeling has been completed 2 Doorways hallways and so forth are a minimum width of 70 cm 28 in 3 Available floor area is sufficient and the fl
53. tions that this document is complete accurate or error free and assumes no responsibility and will not be liable for any errors omissions damage or loss that might result from any use of this document even if the information in the document is followed properly This document is not part of any sales contract between Thermo Fisher Scientific Inc and a purchaser This document shall in no way govern or modify any Terms and Conditions of Sale which Terms and Conditions of Sale shall govern all conflicting information between the two documents Release history Revision A September 2013 Software version Thermo MSQ Plus Mass Detector 2 0 or later Xcalibur 2 2 SP1 or later Foundation 2 0 SP1 2 1 3 0 or later For Research Use Only Not for use in diagnostic procedures IMPORTANT PREINSTALLATION INFORMATION PLEASE READ Thermo SCIENTIFIC MSQ Plus Mass Detector Installation Request Form Dear User Read the MSQ Plus Mass Detector Preinstallation Requirements Guide and then print and complete the following installation request form After all items on the form are fulfilled sign and date the form Then mail or fax this form to your local Thermo Fisher Scientific sales service office The address and fax number for your local office are located on the following pages A 1 All laboratory remodeling has been completed Q 14 Air conditioning is adequate for temperature Q 2 Your MSQ Plus Mass Detector is on
54. tions xv safety standards vii sheath gas 29 shipping containers 4 40 solvents acetic acid 30 acetonitrile 30 41 ammonium acetate 30 ammonium hydroxide 41 filtering 30 impurities 30 isopropyl alcohol 30 41 methanol 29 30 41 recommended 29 30 trap 34 42 traps 35 waste 31 35 41 water 30 space and load requirements 3 4 survey link xvii Swagelok connectors 28 T technical assistance 25 telephones 3 7 40 temperature 9 10 trip hazards 6 Thermo Scientific U uninterruptible power supply 17 24 USB cables 42 V vacuum hoses 6 vibrations 9 11 voltage 19 41 W warranty waste and exhaust requirements 31 water 30 WEEE compliance ix workbenches 3 6 40 Thermo Scientific Index U MSQ Plus Mass Detector Preinstallation Guide 45
55. ts and see the pages indicated in the table for more details Table 3 Operating environment preinstallation requirements Sheet 1 of 2 Requirement Page Temperature 10 The laboratory room temperature must be maintained between 15 and 35 C 59 and 95 F Also ensure that the temperature does not fluctuate by more than 5 C to ensure good performance Humidity 11 The relative humidity of the operating environment must be between 40 and 80 with no condensation Vibration 11 Workbench must be free from vibration MSQ Plus Mass Detector Preinstallation Guide 9 3 Operating Environment Temperature Temperature Table 3 Operating environment preinstallation requirements Sheet 2 of 2 Requirement Page Lighting 111 Adequate lighting for instrument operation is required a high intensity lamp for instrument maintenance Particulate Matter 12 Air should contain fewer than 100000 particles per cubic foot 3500000 particles per cubic meter in excess of 5 um Electrostatic Discharge 12 Thermo Fisher Scientific recommends precautions especially when you are operating the system at the lower end of the relative humidity specification just given You are responsible for providing the operating environment necessary for proper operation of the MSQ Plus Mass Detector LC MS system For precision instrumentation such as the MSQ Plus Mass Detector the temperature stability of the environment in which t
56. ule cm in cm in cm in kg Ib Forepump 30 12 60 24 29 11 34 75 Nitrogen generator 71 28 40 15 7 70 275 60 132 N418LA These dimensions are for an Accela system with a pump autosampler PDA detector and solvent platform with five 1 L solvent bottles filled with solvent Place the MSQ Plus Mass Detector and the data system components on two separate workbenches next to each other One workbench holds the mass detector the LC and any other LC MS options and must have minimum dimensions of 1 x 1 53 m 3 x 5 ft This workbench must also be capable of supporting the weight of the MSQ Plus Mass Detector 60 kg 132 Ibs plus the weight of the liquid chromatograph and any options Allow about 8 cm 3 in of clear space behind the system for proper air circulation and for clearance of the gas lines and electrical connections In addition allow at least 92 cm 36 in of vertical clearance between the top of the mass detector and any shelves above it The second workbench holds the data system computer monitor and printer and must have minimum dimensions of 1 x 1 22 m 3 x 4 ft This second workbench must be capable of supporting the weight of the data system and printer 48 kg 105 Ib Because the total length of the vacuum hose connecting the mass detector to the forepump should not exceed 8 ft install the forepump on the floor close to the mass detector Depending on available space you have two options for the placement of t
57. urplex outlet In the U S only the 15 and 20 A power rating options are available so you must choose the 20 A option Earth ground hard wired to the main panel Connecting the MS LC and Other Modules to Wall Outlets 23 Balance the current load on the circuits to which your system is connected Uninterruptible Power Supply 24 Systems installed in areas with intermittent line power must have uninterruptible power supplies installed Technical Assistance 25 Contact your local office for Thermo Scientific products for additional assistance in monitoring line power or selecting a line conditioner Thermo Scientific MSQ Plus Mass Detector Preinstallation Guide 17 4 Line Power Quality of Power Figure 3 NEMA 6 15P socket Quality of Power The quality of power supplied to your MSQ Plus Mass Detector is very important The line voltage must be stable and within the specifications listed in this guide The line voltage must be free of fluctuations due to slow changes in the average voltage surges sags or transients Below are definitions for the most common voltage disturbances Slow average is a gradual long term change in average root mean square RMS voltage level with typical durations greater than 2 s e Sags and surges are sudden changes in average RMS voltage level with typical durations between 50 ms and 2 s Transients or impulses are brief voltage excursions of up to several thousand vo
58. your power system properly see Table 7 for an example of the number of outlets that might be necessary in your laboratory Table 7 Required wall outlets for a sample laboratory setup Sheet 1 of 2 Item Outlets HPLC system Autosampler Heater LC pump PDA detector External controller Rh MSQ Plus Mass Detector 1 230 V 22 MSQ Plus Mass Detector Preinstallation Guide Thermo Scientific 4 Line Power Connecting the MS LC and Other Modules to Wall Outlets Table 7 Required wall outlets for a sample laboratory setup Sheet 2 of 2 Item Outlets Data system CPU Monitor 1 Printer 1 Nitrogen generator optional MSQ10LA 1 230 V Cone wash pump optional 1 115 V or 230 V High intensity lamp optional for help in instrument maintenance 1 Laboratory stereoscope for inspecting fused silica parts optional 1 useful when performing nanoflow or microfluidic experiments Total outlets required for this configuration 115 Vac Oudets 6 to 11 230 Vac Outlets 1 to 3 Your setup might vary depending on the line voltages and current supplied Connecting the MS LC and Other Modules to Wall Outlets Thermo Scientific Ensure that the wall outlet specifications are not exceeded The maximum load for a 120 Vac fourplex outlet is typically 20 A and the maximum load for a 230 Vac fourplex outlet is typically 16 A See Table 6 on page 22 for the maximum current ratings for th

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