TurboVap® LV
Contents
1. 2x faster than conventional N blow down i Pharmaceutical biotech compounds Unattended operation for up to 50 samples Clinical samples Twelve racks available for tube sizes from 1 5 mL to 30 mL Environmental samples Controlled water bath adjustable from ambient to 90 C Forensic and crime samples Built in nitrogen regulator 7 Drugs of abuse samples Unattended operation improves lab productivity Food and beverage analysis User friendly displays and diagnostics Agrochemical samples Convenient size no hood space required Vortex shearing motor requires no gas supply for operation Easy to use operation interface for time temperature and end point detection settings TurboVap 500 Volume Range up to 500 mL TurboVap 500 can evaporate volumes up to 500 mL down to complete dryness with flat bottomed vessels or to a Selectable endpoint at 0 5 or 1 mL A water bath is used to maintain stable temperature while the cooled glassware condenser collects the solvent The condenser technology allows for efficient and cost effective collection of hazardous waste It also prevents losses of samples and allows for analysis to detect cross contamination issues Built in chiller for solvent recovery Endpoint sensors for 0 5 or 1 mL evaporation Applications In environmental laboratories concentration of large samples is often a time consuming process TurboVap 500 eff2. The Bump free vortex evaporation prevents sample loss while the system s precise temperature control eliminates sample overheating All this to maximize sample recovery and fast turnarounds with the automatic end of run detection Advantages Patented rapid three way drying heating vacuum rotation Evaporation of high boiling solvents Versatile and automated Clean and safe operation Eliminates reformatting Enhanced green chemistry Simple operation Compact footprint Applications Pharmaceutical compound registration Synthetic intermediate isolation Synthetic intermediate re dissolve Evaporation of high boiling point solvents Evaporation Rates 8 mL solvent Specifications Technology Number of samples Sample delivery Max sample volume Vial size compatibility Final endpoint volumes Solvent reclamation Gas supply requirements Exhaust Vacuum operating range Electrical supply Max power consumed Dimensions WxDxH Weight Certifications Biotage V 10 Patented 3 way evaporation including simultaneous heating vacuum and high speed vial rotation 1 16 with carousel 5 mL syringe pump and or peristaltic pump 30 mL single vial 4 mL 3 variants 8 mL HPLC vial 16 ml vial 20 mL scintillation vial 30 mL scintillation vial User selectable volumes Up to 98 of solvent vapors under typical conditions Nitrogen when using pump for solvent deliv
3. C Water bath RT to 90 C Water bath RT to 90 C Water bath RT to 90 C Water bath RT to 95 C Heat block Gas RT to 80 C Heated air Technology Gas vortex shearing technology sensor endpoint detection with either 0 5 mLor 1 0 mL endpoint stems Gas vortex shearing technology sensor endpoint detection with either 0 5 mLor 1 0 mL endpoint stems Gas vortex shearing technology Gas vortex shearing technology Gas vortex shearing technology sensor endpoint detection with either 0 5 mLor 1 0 mL endpoint stems Gas vortex shearing technology Heated gas delivery above and below wells speeds evaporation Patented 3 way evaporation including simultaneous heat vacuum and high speed vial rotation TurboVap Technology Highest Performance Every Time Starting with innovative engineering TurboVap systems from Biotage are designed with extensive customer input and testing The result industry standard design and the highest performance in every way TurboVap evaporators utilize a water bath system providing higher efficiency and control and unlike old heating blocks consistently delivers fast and even results Highly Efficient Patented Gas Vortex Shearing Technology The patented vortex evaporation design makes evaporation up to 10x faster compared to other techniques The vortex created by the moving gas travels down the tube to the solvent surface where it incre
4. K LAE IZ Weight 18 4 kg 40 5 Ibs Certifications 2006 95 EC Low Voltage Directive 2004 108 EC EMC Directive 93 68 EEC CE Marking Directive Advantages Applications Proven equivalency with EPA methods Pharmaceutical biotech compounds Patented vortex shearing technology Clinical samples Patented sensor endpoint detection Environmental samples no monitoring required Forensic and crime samples Unattended operation for 1 6 samples Drugs of abuse samples Controlled water bath is adjustable from ambient to 90 C Food and beverage analysis Operators are free to perform other tasks Agrochemical samples while evaporation is running User friendly displays and diagnostics Convenient bench top size no hood space required Each row of nozzles can be controlled individually with indicator control for each line Adjustable pressure regulator ensures optimal evaporation not visible TurboVap LV Volume Range up to 60 mL The TurboVap LV evaporation system is an automated high speed low volume sample concentrator It is an efficient alternative to the inconvenient set up constant monitoring and long evaporation times that are characteristic of conventional techniques With the TurboVap LV system you simply load and leave A water bath gives an even temperature and gas flow is delivered over a Set time period Turn on1to 5 manifolds depending on the number of samples and the timer
5. ag Technological Advantages for High Performance Unmatched Performance and Throughput The RapidTrace reduces time consuming manual sample preparation methods and ensures that processing times match analytical capabilities Every step of the sample preparation process is automated and rigorously controlled to give you a level of reproducibility unmatched by manual techniques All sample and solvent flow rates are individually controlled under positive pressure Each step in the processing can be optimized for maximum accuracy and precision NEW Compatible with 1 3 and 6 mL SPE Columns Increased bed height enables the use of a wider range of SPE cartridges including all ISOLUTE and EVOLUTE bed masses allowing for flexibility in methodology NEW Larger sample volumes A new 5 position rack for 40 mL scintillation vials allows for larger sample volumes to be processed often desired for food and environmental applications NEW Delay Start feature Easily leave extracted samples unattended Extracts are freshly prepared when you return Modular design allows for up to 10 linked units The Modular design allows users to start with one module and expand up to 10 linked units Modules within a group can run different methods independently and if one module is shut down for operator attention other units remain operational so that sample throughput is not halted Accelerated methods development and optimization Utili
6. extractions TurboVap Il is available in a Dionex ASE compatible setup which accommodate the use of six 40 mL stemmed and gradu ated Dionex ASE tubes Upgrade kits are also available for converting your old TurboVap Il Dionex ASE is a registered trademark of Dionex Thermo Fischer Solvent Evaporation Fast Reliable and Affordable Biotage 2013 TurboVap Il Evaporation Rates 180 mL solvent Specifications Bath temp cas Approx Technology Gas vortex shearing evaporation Solvent 5 pressure 3 i C psi time min with sensor endpoint detection P Available with either 0 5 mL or 1 0 Dichloromethane 40 10 35 mL endpoint stems Hexane 55 10 25 Number of samples 1 6 Acetone 55 10 27 Timer range 1 to 99 min or 0 1 to 9 9 hrs Methanol 50 12 70 Max sample volume 200 mL Acetonitrile 50 12 79 Final endpoint volumes 0 5 or 1 mL Toluene 50 10 90 Solvent reclamation Water 90 18 120 Water bath capacity 6 4 L of distilled water Water bath temperature Ambient to 90 C upper temperature with sensors is 60 C Gas supply requirements Minimum inlet pressure 30 psi 2 1 bar Maximum inlet pressure 80 psi 5 5 bar Gas consumption At 11 psi 0 08 cfm nozzle or 2 3 L min nozzle Exhaust 25 CFM blower with 5 1 cm 2 venting exhaust tube supplied Electrical supply 220 240 V 50 Hz 5A UK amp EU 100 120 V 50 60 Hz 10A USA amp JP Max power consumed 900 VA Dimensions WxDxH 5930 icmibe30 55G Mme OSEM Di
7. following SPE cleanup of drug sampels or pesticide extracts TurboVap LV 24 ASE version ae 40 mLor Food water soil and 60 mLASE environmental solvent tubes extraction 2 500 mL Larger samples water testing in remote locations with simple lab equipment Comes with solvent recovery functionality as default 96 x 2 Up to 2mL Genomic and proteomic applications that require concentration of purified extracts Widely used for drugs of abuse and other pharmaceutical SPE methods Biotage SPE 24 48 Up to Forensic clinical chemistry Dry 96 and 10 mL food and pharmaceutical 384 well depending laboratories for microplates on format concentration of solvents following SPE cleanup of drug samples or pesticide extracts Biotage V 10 1 Up to High BP solvents reversed 12 mL phase HPLC fractions depending on vial Typical Solvents Acetone Acetonitrile Methanol Dichloromethane Toluene Acetone Acetonitrile Methanol Dichloromethane Toluene Acetonitrile Ethylacetate Hexane Methanol Dichloromethane Acetonitrile Ethylacetate Hexane Methanol Dichloromethane Acetone Hexane Methanol Dichloromethane Acetonitrile DMSO Dimethyl sulfoxide Ethanol DMF Dimethyl formamide THF Tetrahydrofuran Acetonitrile DMF Methanol Propan 2 ol DMSO Almost all solvents especially good for DMF DMSO MeCN water MeOH water NMP Heating Water bath RT to 90
8. hours or Acetonitrile 60 12 22 infinite 70 12 15 Max sample volume 30 mL 60 mL with ASE version Dichloromethane 35 12 20 aoe endpoint J MeCN water 70 12 65 HUE Solvent reclamation 35 12 35 h 50 12 15 Water bath Ambient to 90 C Temperatures Ethylacetate temperature below ambient can be regulated using 60 12 10 the cooling effect of the evaporation 70 12 7 process Methanol water 70 12 65 Gas supply Minimum inlet pressure 60 psi 4 1 bar 35 12 50 requirements Maximum inlet pressure 100 psi 6 9 bar Methanol 50 12 26 Gas consumption At 10psi 0 06 cfm nozzle or 0 6 cfm 60 12 18 row of 10 nozzles or 1 699 L min nozzle 50 12 210 At 15psi 0 1 cfm nozzle or 1 cfm row of Water 60 12 140 10 nozzles or 2 83 L min nozzle 70 12 100 Exhaust 5 1 cm 2 venting exhaust tube Supplied Electrical supply 220 240 V 50 Hz 5 A UK amp EU 100 120 V 50 60 Hz 10 A USA amp JP Max power consumed 900 VA Dimensions WxDxH 53 8 cm x 30 2 cm x 30 2 cm DR XA Se Xe Ss Weight 18 4 kg 40 5 Ibs Certifications 2006 95 EC Low Voltage Directive 2004 108 EC EMC Directive 93 68 EEC CE Marking Directive Advantages No tube balancing required Patented vortex shearing technology Easily swap racks to change between different tube sizes Proven compliance with EPA methods Requires no additional equipment such as vacuum pumps and vacuum traps 10x faster than centrifugal evaporators PERE P 3x faster than hot blocks Applications
9. mm fraction sample 16 x 100 mm fraction tube e 13 x 100 mm fraction sample 12 x 75 mm fraction tube 9 position chilled rack e 40 mL sample flash 5 position 16 x 100 mm fraction tube oo SO e O Rings The O Rings used on the RapidTrace are subject to wear and will need to be replaced occasionally depending on usage 6 mL SPE O Ring CHEMRAZ 3 mL SPE O Ring CHEMRAZ 1 mL SPE O Ring CHEMRAZ Cannula SPE O Ring CHEMRAZ Waste Station O Ring CHEMRAZ 6 Accessories Vial Adapters These adapters are designed for use with the 13 x 100 mm sample tube with 12 x 75 mm fraction tubes to collect the fraction directly into a vial rather than a test tube Transferring the sample from a test tube to a vial takes additional time and can result in a loss of some of the sample There are two adapters available e 11 mm diameter vial standard 1 5mL GC vial e 4 mL vial threaded HPLC vial Test Tubes Disposable borosilicate glass test tubes for RapidTracet These tubes are also compatible with TurboVap LV Evaporator for further downstream processing e 12x 75mm e 13 x 100 mm e 16 x 100 mm Related Products SPE Solutions Biotage manufactures a wide range of products to ensure options based on the degree of cleanliness required and the cost effectiveness demanded by the analysis Solid Phase Extraction Supported Liquid Extraction and Protein Precipitation techniques are uniqu
10. simplify hazardous waste handling and reduce disposal costs Simple and Reliable Simple rugged design with a minimum of moving parts and easily accessible consumables allows for a robust system with minimum down time Technical Specifications Column sizes Waste outlets e 1 3 0r6mL e 4 separate Sample size Gas inlet optional e 0 1 mL to 14 mL e 1 gas inlet 2 8 bar maximum C50000 RapidTrace Workstation 3 mL 0 1 to 40 mL with upgrade to new rack sensor Connections 0 1 mL to 40 mL e RS232 Input Connects the module to the controller C125713 RapidTrace Workstation 6 mL RS232 Output Used when multiple modules are connected Syringe pump e Load Volume 0 1 mL to 5 8 mL Dimensions e 10cm x 55 cm x 60 cm WxDxH Flow rates e 0 1 mL min to 42 mL min 0 006 mL sec to 0 7 mL sec Weight oe _ e 14 5 kg Liquid Handling Accuracy e Volumes 3 0 mL 1 Power Requirements Se me e 50 60 Hz 100 240 VAC 10 Mixing Capability Cycle e Maximum mixing volume of 5 0 mL in mixer Liquid Sensing e Volumes of 1 2 mL or larger Solvent inlets e 8 reagent inlets individually configurable aspirate dispense rates Magnetically Encoded Racks Compliance validation Magnetically Encoded Racks enable the user to designate Each unit includes a Validation Manual that allows operators a specific method to a rack to walk through the validation process of their RapidTrace This ensures that the instrument provides the consiste
11. 1 rack C58309 16x100 mm sample tube 16x100 mm fraction tube 1 rack C56786 13x100 mm sample tube 12x75 mm fraction tube 9 Position Chilled Rack 1 rack C56536 40 mL sample flask 5 position 16x100 fraction tube 10 position 1 rack C133968 Magnet kit for encoding racks 10 pack C54405 O Rings 6 mL SPE O Ring CHEMRAZ 1 O Ring C46643 3 mL SPE O Ring CHEMRAZ 1 O Ring C45096 1 mL SPE O Ring CHEMRAZ 1 O Ring C60969 Cannula O Ring CHEMRAZ 1 O Ring C45096 i O Ring C52526 Miscellaneous 6 mL Column Plunger 1 C69983 3 mL Column Plunger il C52231 1 mL Column Plunger 1 C52229 3 mL SPE Gel Adapter Kit 1 C58728 1 mL SPE Gel Adapter Kit 1 C58759 1 mL Adapter Sleeves kit of 11 C59807 Tubing Weight Kit for Reagent Lines 8 weights C50973 Check Valve Kit for Manifold Reagent Lines 8 valves C55076 The Advantages of Upgrading Your Current RapidTrace A broader range of SPE columns Increased bed height capability enables the use of the most industry standard columns Software upgrade 2 1 Customer installable software and firmware including the entire Biotage ISOLUTE and EVOLUTE range of 1 3 and 6 mL columns allowing for a more flexible approach to sample volume Run 40 mL sample volume A new 5 position rack for 40 mL scintillation vials for processing sample volumes up to 40 mL Run 6 mL columns The 5 position turret for 6 mL columns is updated for easier column loading unloading Additionally adapters enable
12. 16 mm rack VacMaster 10 Replacement Parts Part Number Description 121 1039 Replacement tank with fittings 121 1045 Replacement lid with fittings 121 1030 Silicone Lid Gasket 121 1132 Replacement rack 10 mm 121 1133 Replacement rack 12 mm 121 1134 Replacement rack 16 mm VacMaster 20 Sample Processing Manifold Part Number Description 121 2010 Sample Processing Manifold with 10 mm rack 121 2012 Sample Processing Manifold with 12 mm rack 121 2016 Sample Processing Manifold with 16 mm rack VacMaster 20 Replacement Parts Part Number Description 121 2068 Replacement tank with fittings 121 2075 Replacement lid with fittings 121 2059 Silicone Lid Gasket 121 2161 Replacement rack 10 mm 121 2162 Replacement rack 12 mm 121 2163 Replacement rack 16 mm VacMaster Accessories Part Number 121 0010 Description PTFE T valve for connecting 2 tanks Qty H_ HH H H H Qty HH H H H Qty Biotage VacMaster 10 amp 20 Sample Processing Manifolds PTFE Stopcock Option and Spare Parts Part Number Description 121 0009 121 0001 121 0002 121 0003 121 0004 121 0005 121 0009 S Universal PTFE stopcock PTFE stopcock needle unit PTFE needle Stainless steel needle Stainless steel needle retainer Port sealing plugs PTFE stopcock pressure positive Qty 10 10 10 20 10 30 10 Biotage 2014 SL 52 Biotage VacMaster 96 Samp
13. 2 Well removing tool 1 Biotage 2014 2014 Analytical Sample Preparation Catalog Automated Sample Processing Products Biotage2014 55 RapidTrace Automated High Throughput Solid Phase Extraction ha a Reagent mixing chamber allows automated online reagent blending in the method Closed fluid path system with segregated waste lines maintain integrity of sample if Eight solvent reagent lines for maximum methods flexibility Positive pressure stepper motor syringe pump delivers precise flow rates 2 T Compatible 1 3 and 6 mL version SPE columns Magnetically encoded racks of routine samples Part Number Description Part Number Description Qty C50000 RapidTrace Workstation Racks Each RapidTrace requires one rack 1 mL and 3 mL 10 columns C50974 13 x 100 mm Sample Tube 1 C125713 RapidTrace Workstation i Da gl Li 6 mL 5 columns 3 mL and 1 mL i i z operation possible by purchasing appropriate C50976 13 x 100 mm Sample Tube Pk 5 i hure plunger see accessories brochure 12 x 75 Fraction Tube C52006 RapidTrace Start Up Kit with Software C52689 RapidTrace Notebook Controller Coeur om Semple ane 13 x 100 mm Fraction Tube C56786 16 x 100 mm Sample Tube 1 RapidTrace Brochure K 00 ain actu For further information please visit www biotage com to C56596 13 x 100 mm Sample Tube 1 request a copy of our RapidTrace brochure 12 x 75 mm Fraction Tube 9 Posit
14. 69 Tube Rack for 16 x 125 mm tubes P N C45273 250 tubes included C44282 Tube Rack for 20 x 150 mm tubes P N C40709 250 tubes included C44283 Tube Rack 16 x 100 mm Prelude compatible C44880 Tube Rack for 15 mL Conical Centrifuge Tubes P N C44941 125 tubes included C47818 Tube Rack 15 mL Autotrace tubes with conical bottom suitable for tubes C47816 C47820 Tube Rack 10 mL conical tubes suitable for tubes C47811 C48928 Tube Rack 1 5 2 0 mL flip cap microcentrifuge tubes C48929 Tube Rack 1 5 2 0 mL screw cap microcentrifuge tubes C59546 Tube Rack GC vials C61345 Tube Rack ASE 40 60 mL IChem Vials For further information please visit www biotage com to request a copy of our Evaporation brochure Biotage 2014 59 Solvent Evaporation Fast Reliable and Affordable Biotage Fast Automated and Safe Drying of Solvents The Widest Range of Evaporation Solutions Available CONTENTS Biotage Evaporation System Selection Guide TurboVap Technology TurboVap Family TurboVap Il TurboVap LV TurboVap 500 TurboVap 96 Biotage SPE Dry Biotage V 10 Evaporator Accessories Related Products TurboVap LV Tubes and Racks Chart 20 Ordering Information 2013 Biotage Trademark Acknowledgement The following trademarks are owned by Biotage AB Advancer Advancer 350 Advancer Kilobatch AFFINILUTE Biotage Biotage ZIP Endeavor EVOLUTE EVOLUTE EXPRESS ExploraSep Extrahera Firefly des
15. Evaporation Biotage SPE Dry 96 amp 96 Dual Sample Concentrator System Biotage SPE Dry 96 Sample Concentrator System Part Number Description SD 9600 DHS NA SPE Dry 96 Sample Concentrator SPE Dry 96 Dual Biotage System 100 120V a SD 9600 DHS EU SPE Dry 96 Sample Concentrator System 220 240V 8888 SD 9600 DHS T NA SPE Dry 96 Sample Concentrator System with PTFE coated needles Top Head Only 100 120V SD 9600 DHS T EU SPE Dry 96 Sample Concentrator System with PTFE coated needles Top Head Only 220 240V Biotage SPE Dry 96 Dry Dual Sample Concentrator System Part Number Description SD2 9600 DHS NA SPE Dry 96 Dual Sample Concentrator System 100 120V SD2 9600 DHS EU SPE Dry 96 Dual Sample Concentrator System 220 240V SD2 9600 DHS T NA SPE Dry 96 Dual Sample Concentrator System with PTFE coated needles Top Head Only 100 120V SD2 9600 DHS T EU SPE Dry 96 Dual Sample Concentrator System with PTFE coated needles Top Head Only 220 240V Evaporation Brochure For further information please visit www biotage com to request a copy of our Evaporation brochure Solvent Evaporation Fast reliable and affordable e Biotage 58 Biotage 2014 2014 Analytical Sample Preparation Catalog TurboVap Evaporators and Concentrators TurboVap Product Family TurboVap 500 TurboVap 96 TurboVap II TurboVap LV Part Number Description TurboVap 500 C103202 TurboVap 500 100 120V 50 60H
16. MC Directive 93 68 EEC CE Marking Directive Approx time C min 15 10 37 25 13 33 25 12 23 100 43 O OF OF AO A A A A OA A A A AN OV Easy to use interface for time and temperature operation Individual control for each compartment TurboVap 96 Deep or Shallow 96 well Plates The TurboVap 96 Concentration Workstation is a high speed concentrator designed to work with 96 well microplates and deep well plates It is an efficient alternative to the constant monitoring and long evaporation times that are characteristic of conventional techniques with the added bonus of unattended operation The evaporation process is driven by Biotage s patented gas vortex action further enhanced by a temperature controlled environment and adjustable gas flow rates This combination saves time bench space and operating costs while improving the evaporation speed and sample tosample consistency Unique nozzle design ensures fast and efficient vortex shearing evaporation Adapters support different plates and depths Dual gas regulators one for each plate operated individually for greater flexibility Applications TurboVap 96 has two independent compartments that accommodate 1 mL or 2 mL standard or deep well plates Each compartment has independent control of gas flow and tempera ture The flow rate of the gas is determined by the volume of solvent in the plate and the temperature values can
17. Top needle assembly PTFE coated 24 channel Accessories Dual Plate Spare upper needle head assembly 2 x 96 straight needles coated Spare upper needle head assembly 2 x 384 straight needles coated 410648 410649 411031 411032 411033 411037 411181 411182 411183 411816 Part Number SD 9600 DHS NA SD 9600 DHS EU SD2 9600 DHS NA 5D2 9600 DHS EU ntact a Biotage SD 9601 T SD 9601 384 T SD 9601 T 24 SD2 9601 T SD2 9601 384 T 21 Manual Sample Processing fl Products and Accessories Biotage PRESSURE 48 and PRESSURE 96 Positive Pressure Manifolds Biotage PRESSURE 96 Part Number Description PPM 96 PRESSURE 96 Positive Pressure Manifold 96 position Includes 1 x 1 mL 96 well collection plate 1x 2 mL 96 well collection plate 1 x 10 mL 24 well collection plate waste plate 96 column sealing gasket gas supply adaptor kit 6 of 1 8 i d polyethylene tubing and 1 8 and 1 4 NPT connectors User Manual CD ROM Accessories PPM A96 GSKT PRESSURE 96 Sealing Gasket 96 position PPM A96 1024 PRESSURE 96 Collection Tray 10 mL 24 well PPM GA PRESSURE Gas Supply Adaptor for all models 121 5202 96 well collection plate 1 mL pack of 50 121 5203 96 well collection plate 2 mL pack of 50 Biotage PRESSURE 48 Part Number Description PPM 48 PRESSURE 48 Positive Pressure Manifold 48 position Includes Sealing gasket 48 position gas supply adaptor kit 6 o
18. TurboVap 96 Gas vortex shearing technology 2 x 96 well plates standard or deep with adapters 8 x 12 well microplates and deep well plates 1 to 99 minutes lt 2 mL 2 standard 96 well microplates or deep well plates Two internal individually controlled heaters Each adjustable from ambient to 80 5 C Minimum inlet pressure 30 psi 2 1 bar Maximum inlet pressure 80 psi 5 5 bar 5 99 cfm 25 CFM blower with 5 1 cm 2 venting exhaust tube supplied 70 psi 220 240 V 50 Hz 3 A UK amp EU 100 120 V 50 60 Hz 6 A USA amp JP 620 VA 30 5 cm x 30 5 cm x 61 cm OX 18 4 kg 40 5 Ibs 2006 95 EC Low Voltage Directive 2004 108 EC EMC Directive 93 68 EEC CE Marking Directive Time to evap to cubic ft hr dryness Methanol 500 70 60 12 min Water 500 80 60 70 min Acetonitrile 500 70 60 25 min Acetonitrile water 50 50 1000 60 70 SENES THF Tetrahydrofuran 1000 50 50 10 15 min DMF Dimethylformamide 1000 80 70 50 min DMSO Dimethyl sulfoxide 250 70 60 3 hrs 1 Above studies were conducted with clean solvent in a standard 2 mL polypropylene 96 well deep well microplate 2 Not the temperature of the solvent in the well 3 The conditions set on the TurboVap temperature and flow rate may not be optimum settings for most efficient evaporation rates 11 SPE Dry 96 Dual PTFE coated needles available as option when evaporating acids and harsh solvents Available with sing
19. ample homogeneity and continuous rinsing of the tube wall Solvent Evaporation Fast Reliable and Affordable Biotage 2013 TurboVap Family TurboVap Family Choose the Solution That s Right for You TurboVap II TurboVap LV The TurboVap II Concentration Evaporator Workstation is The TurboVap LV Low Volume Concentration Evaporator a microprocessor controlled concentrator for unattended Workstation offers many interchangeable tube racks giving you automated sample evaporation the flexibility for automated low volume sample preparation The e Unattended and automated microprocessor controlled monitoring system regulates timed e Optical sensor endpoint detection operation water bath temperature e 6 individually controlled vial automatic gas shutoff and operational positions diagnostics No fume hood needed e 50 positions with user selectable racks for greater flexibility e 1 5 30 mL volume TurboVap 500 TurboVap 96 The TurboVap 500 Concentration Evaporator Workstation is a The TurboVap 96 Concentration Evaporator Workstation is a closed cell evaporation system that delivers automated sample microprocessor controlled evaporation system for simultaneous concentration and solvent recovery using helical gas flow and automated and unattended concentration of multiple samples sensor endpoint detection technology e 2 positions with individual gas regulation e Compatible with 96 well standard or deep well p
20. ases the gas solvent interface providing faster evaporation than conventional methods The combination of gas flow and temperature control is used to optimize the sample drying Nitrogen is recommended as the best choice of gas because it is inert and minimizes the risk of oxidation A clean oil free compressed air supply at 60 psi can be used if the sample is stable and or nitrogen is not available Automated Evaporation Completion The patented sensor technology alerts you with an audible alarm when evaporation is complete This prevents the sample from going dry and volatiles from being lost Sensor end point detection is available with either 0 5 mL or 1 0 mL end point stems Fast Consistent and Even Results TurboVap 500 does not require a fume hood or external gas supply for operation Itis designed as a closed system with up to 95 solvent recovery function for safe and economic waste handling Gas Manifold Nozzle 56 Figure 1 Principle of the gas vortex shearing technology The position of the gas nozzle close to the tube wall is important for optimized evaporation Microplate Well 5 Gas Vortex 7 Shearing Action Figure 2 The selection between 0 5 mL and 1 mL end point detection is easily done with a quick modification of spacers 0 5 mL mark and 0 5 mL end point 1 mL mark and i mL end point Figure 3 The helical flow establishes a vortex action that promotes s
21. be set with the help of an evaporation guide supplied Nozzles are easy to clean and require minimal maintenance In genomic and proteomic applications the evaporation of DMSO from plates is acommon application As is drying HPLC aqueous solvent mixtures of methanol or acetonitrile TurboVap 96 complements automated 96 well SPE workstations that are widely used for drugs of abuse determination and other pharmaceutical SPE methods Solvent Evaporation Fast Reliable and Affordable Biotage 2013 Advantages Patented vortex shearing technology Operators are free to perform more important tasks further improving lab productivity No bumping means no re working of samples saving you money every week User friendly displays and diagnostics Convenient bench top size no hood Space required applications Pharmaceutical biotech compounds Clinical samples Environmental samples Forensic and crime samples Drugs of abuse samples Food and beverage analysis Agrochemical samples Evaporation Rates Solvent Solvent volume uL Heater temp C Specifications Technology Number of samples Format Timer range Max sample volume Final endpoint volumes Capacity Heaters Gas supply requirements Range Exhaust Minimum operating pressure Electrical supply Max power consumed Dimensions WxDxH Weight Certifications Gas flow rate
22. ely supported by consumables automation and accessories Your Biotage representative can help you choose the best solution for your needs Solvent Evaporation Biotage offers the largest range of solvent evaporation systems designed for faster evaporation of volatile and high boiling solvents and sample transfer minimization Utilizing patented vortex shearing technology rotation controlled heating or vacume technology Biotage will automate your process Ask your representative about e TurboVap systems e SPE Dry e V 10 Ordering Information RapidTrace Product RapidTrace Systems RapidTrace Workstation Quantity Part Number 1 mL and 3 mL 10 columns 1 C50000 RapidTrace Workstation 6 mL 5 columns 3 mL and 1 mL only with appropriate plunger 1 C125713 see accessories RapidTrace Start Up Kit w Software 1 C52006 RapidTrace Notebook Controller 1 C52689 Accessories Product Quantity Part Number Racks Each RapidTrace requires one rack 13x100 mm sample tube Product Quantity Part Number Vial Adapters 11 mm Vial Adapter 4 mL Vial Adapter 10 adapters C55091 10 adapters C55827 Test Tubes 12 x 75 mm Test Tubes uncapped 1 000 case C44651 1 000 case C40707 1 000 case C40708 13 x 100 mm Test Tubes uncapped 16 x 100 mm Test Tubes uncapped 12x75 mm fraction tube 1 rack C50974 13x100 mm sample tube 12x75 mm fraction tube 5 racks C50976 13x100 mm sample tube 13x100 mm fraction tube
23. er C103198 C103199 C103200 C103201 C60911 Gl12175 C133718 C48985 C44651 C40707 C40708 C45273 C40709 C47811 C44941 C44942 Product Racks Tube Rack 1 5 2 0 mL flip cap microcentrifuge Tube Rack 1 5 2 0 mL screw cap microcentrifuge Tube Rack 10 x 75 mm Tube Rack 12 x 75 mm Tube Rack 13 x 100 mm Tube Rack 16 x 100 mm Tube Rack 16 x 100 mm prelude compatible Tube Rack 16 x 125 mm Tube Rack 20 x 150 mm Tube Rack 10 mL conical Tube Rack 15 mL conical Tube Rack 15 mL volumetric autotrace Tube Rack ASE i Chem Vials TurboVap LV TurboVap 96 Product TurboVap 96 100 120V 50 60 Hz TurboVap 96 220 240V 60 60 Hz Biotage V 10 Evaporator Product 110V AC USA with syringe pump with peristaltic pump with dual pumps with syringe pump and carousel drive unit with peristaltic pump and carousel drive unit with dual pumps and carousel drive unit 230V AC EU with syringe pump with peristaltic pump with dual pumps with syringe pump and carousel drive unit with peristaltic pump and carousel drive unit with dual pumps and carousel drive unit 100V AC JPN with syringe pump with peristaltic pump with dual pumps with syringe pump and carousel drive unit with peristaltic pump and carousel drive unit with dual pumps and carousel drive unit Part Number C48928 C48929 C48950 C44577 C45286 C44139 C44283 C45269 C44282 C47820 C44880 C47818 C61345 Pa
24. ery Double trapping Ambient to 2 mbar 220 240 V 50 Hz 8 A UK amp EU 100 120 V 50 60 Hz 15 A USA amp JP 1700 VA 49 cm x 54 cm x 53 cm 19 3 x 21 3 x 20 9 50 kg 110 Ibs EN 61010 1 2001 Low Voltage Directive EN 61326 1 EMC Directive UL 61010 1 2004 CAN CSA C22 2 No 61010 1 04 FCC part 15 Centrifugal Evaporation Blowdown Evaporation Solvent Boiling Point C V 10 Evaporation min min min NMP 202 18 N A N A DMSO 180 15 180 N A DMF 150 4 90 N A Pyridine 115 SHE 70 N A Water 100 9 140 240 Methanol 65 3 70 40 Cydohexane 81 2 5 40 20 15 Accessories Vial Adapters for Biotage V 10 Several vial adapters are available for 4 mL 8 mL and other vial types including 4 mL straight side vials Gilson Liquid Handler for Biotage V 10 The Gilson GX 271 liquid handler enables fully automated evaporation together with V 10 Evaporate chromatography fractions directly from the chromatography system rack without manual intervention TurboVap Il ASE Conversion Kit With the Dionex ASE and the ASE Compatible TurboVap Il a six position rack will accommodate the use of 40 mL stemmed tube with 1 mL endpoint This tube is available through Dionex Corporation For further information please contact Dionex at 1 800 523 4571 Vial Carousels for Biotage V 10 For automated drying of several solutions vial carousels are available for 4 mL vials and 20 mL scintillation v
25. f 1 8 i d polyethylene tubing and 1 8 and 1 4 NPT connectors waste bin rack waste bin inserts User Manual CD ROM Racks must be ordered separately Racks PPM A48 1RCK PRESSURE 48 SPE Column Rack 1 mL PPM A48 3RCK PRESSURE 48 SPE Column Rack 3 mL PPM A48 6RCK PRESSURE 48 SPE Column Rack 6 mL PPM A48 1275 PRESSURE 48 Collection Rack 12 X 75 mm PPM A48 13100 PRESSURE 48 Collection Rack 13 x 100 mm PPM A48 1232 PRESSURE 48 Sample Vial Rack 12 x 32 mm PPM A48 16100 PRESSURE 48 Collection Rack 16 x 100 mm Accessories PPM A48 GSKT PRESSURE 48 Sealing Gasket 48 position PPM A48 WST PRESSURE 48 Waste Bin Inserts PPM GA PRESSURE Gas Supply Adaptor for all models 50 Biotage 2014 Service Options Part Number Description SER PPM IN PRESSURE Manifold Service Installation SER PPM PL PRESSURE Manifold Platinum Service Contract 1 year SER PPM SLVR PRESSURE Manifold Silver Repair Depot Service Contract 1 year SER PPM FYMP PRESSURE Manifold 9 month extended warranty 1 year total 2014 Analytical Sample Preparation Catalog Biotage VacMaster 10 and 20 10 or 20 position vacuum manifolds for SPE SLE and filtration applications als VacMaster 10 Sample Processing Manifold Part Number Description 121 1010 VacMaster 10 Sample Processing Manifold with 10 mm rack 121 1012 VacMaster 10 Sample Processing Manifold with 12 mm rack 121 1016 VacMaster 10 Sample Processing Manifold with
26. ials High vacuum Pumps for Biotage V 10 For the enhanced evaporation of high boiling solvents DMSO NMP an external high vacuum pump is necessary Biotage offers two models the oil based Vacuubrand RZ 2 5 and the oil free Edwards XDS5 TurboVap LV ASE Conversion Kit Convert TurboVap LV to 24 sample positions suitable for ASE I Chem vials The kit comes with a rack with a removable shelf that allows the user to convert the rack from 40 mL to 60 mL vials and vice versa This rack can also be used for the gradu ated stemmed 4o mL Dionex vials Solvent Evaporation Fast Reliable and Affordable Biotage 2013 Related Products RapidTrace RapidTrace is a robust automated platform for sample preparation designated for solid phase extraction SPE It is used in pharmaceutical clinical and forensic laboratories to develop and process rugged and reliable methods RapidTrace eliminates SPE bottlenecks so you can realize the full benefits of today s powerful analytical instruments Biotage PRESSURE 48 amp 96 PRESSURE manifolds deliver parallel positive pressure processing for 96 well plates in 1 mL 3 mL and 6 mL column formats The systems utilize a consistent uniform flow of positive pressure to move both low and high viscosity liquids through SPE plates and columns Each port of the PRESSURE manifold independently maintains constant pressure increasing the overall reproducibility of analyte rec
27. iciently concentrates organic solvent extracts to 0 5 or 1 0 mL and sounds an alarm when finished This load and leave capability frees the analyst for more important work TurboVap 500 is also an excellent alternative to traditional rotary evaporators used in organic synthesis With a500 mL solvent capacity and water bath temperatures up to 95 C synthesis mixtures are processed quickly The unique vortexing action maintains the components of interest in the solvent during evaporations and minimizes the plating of the compounds on the vessel walls The open top cylindrical design of the sample tube with a small stem at the bottom provides an easy way to recover the products of interest when the evapora tion is completed Solvent Evaporation Fast Reliable and Affordable Biotage 2013 Advantages Patented vortex shearing technology Patented sensor endpoint detection Operators are freed to perform othertasks further improving lab productivity No bumping means no re working of samples saving you money every week Solvent vapor recovery system laboratory emissions can be greatly reduced User friendly displays and diagnostics Convenient bench top size no hood space required No need for fume hood Portable no gas required applications Environmental samples Agrochemical samples Forensic and crime samples Drugs of ab
28. ign 9 FLASH FlashMaster FlashVac Flash 75 Flash 150 Flash 400 Horizon HPFC HP SIL HP Sphere Initiator Initiator Peptide Workstation Initiator Initiator Alstra Initiator Robot 60 Initiator Robot 8 Initiator SP Wave Isolera Isolera Dalton Isolera Dalton Mass Detector Isolera Dalton Nanolink Isolera Dalton System Isolera Four Isolera LS Isolera One Isolera Prime Isolera Spektra Isolera Spektra Four Isolera Spektra LS Isolera Spektra One ISOLUTE ISOLUTE Myco ISOLUTE QuEChERS IST IST design GW KILOPREP KP C18 HS KP C18 WP KP C4 WP KP NH KP Sil KP Sphere MIP Rule of 6 MIP 4 Process MIP 4 Proteins MIP4SPE PathFinder PRESSURE PRESSURE 48 PRESSURE 96 RapidTrace RapidTrace RENSA Resolux Robot 60 Robot 8 Samplet SIM SNAP SNAP Ultra SNAP XL SP Wave SP1 SP4 SPE Dry SPE Dry 96 SPE Dry 96 Dual SPx Syro Wave TurboVap Universal Phase Separator V 10 VacMaster ZIF ZIF SIM ZIP Sphere 1 Point Support Biotage offers the widest range of solvent evapora tion systems available This guide presents the most suitable evaporation system for your research requirements and answers common questions regarding service maintenance and applications Evaporation systems can be found in virtually every type of laboratory from drug discovery to analytical chemistry Biotage evaporation instruments are commonly used in many applica tions and have been the market s preferred choice for decades For s
29. ion Chilled Rack C133968 40 mL Sample Flask 5 position 1 16 x 100 Fraction Tube 10 position RapidTrace Automated SPE Workstation ae ae Biotage Ssotage On ar pipe 56 Biotage 2014 2014 Analytical Sample Preparation Catalog Instruments RapidTracet Accessories Racks Vial Adapters Test Tubes O Rings Miscellaneous Biotage Automate Your Extractions Increase your throughput and productivity The RapidTrace is a robust automated The SPE Landscape i i Advanced bioanalytical techniques like LC MS MS platform for quickly developing rugged and GC MS are meeting the increasing demand for reliable SPE methods in regulated greater speed and specificity in toxicological screening Conventional sample preparation methods have not pharmaceutical clinical and forensic kept pace Solid phase extraction SPE in particular i m ae an essential step in the analysis of many biomolecules laboratories The RapidTrace eliminates has become a throughput limiting factor in many SPE bottlenecks so you can realize the aerate full benefits of today s powerful The New Solution The RapidTrace is the perfect complement to high speed analytical techniques a powerful high throughput workstation dedicated specifically to SPE In its fully modular configuration a ten module workstation can process up to 100 samples per hour analytical instruments The RapidTrace delivers e More samples per headcount e Faster turnaro
30. itted filtration column 100 25 mL 20 um PE 120 1028 F ISOLUTE double fritted filtration column 50 70 mL 20 um PE Sulfate Drying Cartridge Biotage 2014 47 48 Accessories For SPE and Filtration ISOLUTE Filtration Plates Each well contains a 20 um polyethylene frit for high throughput filtration applications Part Number Description Qty 120 1022 P01 Filtration plate fixed well 1 2 mL 20 um Plate Sealing Accessories Seal wells and Luer outlets of ISOLUTE 96 fixed well plates Piercable sealing cap can also be used to seal collection plates Part Number Description Qty 121 5204 Piercable Sealing Cap 50 121 5205 Luer Cap Mat 25 Deep Well Collection Plates 1 or 2 mL volume per well constructed from high purity solvent resistant polypropylene Seal with piercable sealing cap Part Number Description Qty 121 5202 Collection plate 1 mL 50 121 5203 Collection plate 2 mL 50 Array Accessories Populate the reusable base plate to transfer individual Array wells into microplate format Seal any unused positions with base plate plugs Align wells and depopulate base plate after use with the well removing tool Use Luer adaptors to process individual Array wells using a VacMaster 10 or 20 vacuum manifold Part Number Description Qty 120 1000 P01 ISOLUTE Array base plate 1 120 1200 ISOLUTE base plate sealing strips 50 strips of 8 120 1201 Luer Adaptors 25 to fit any vacuum manifold 120 120
31. lates e Solvent vapors are collected by the condensers on the side walls for waste or reclamation 2 individually controlled positions 500 mL volume 0 5 or 1 0 mL endpoint stems No fume hood needed Easy to use programming interface with individual tube control Adjustable pressure regulator ensures optimal evaporation not visible TurboVap II Volume Range 50 mL or 200 mL TurboVap Il increases the capacity and sample throughput in laboratories eliminates concentration bottlenecks and maintains quality and lower costs This instrument has 6 sample positions and enables the user to evaporate to solid state or concentrate into a fixed end point volume The small footprint of TurboVap Il makes it the ideal choice in today s laboratories It takes up only a fraction of the bench space used by conventional rotary evaporators and can even be used outside a fume cupboard by using the integral vent tube Glass window enables easy overview of the evaporation progress End point detection terminates evaporation at 0 5 mL or 1 0 mL volumes Applications The TurboVap Il Evaporation System efficiently concentrates samples prior to analysis by LC MS or other analytical instru ments Optical sensors automatically stop gas flow when evaporation has reached its end point thereby eliminating the risk of drying and loss of volatile compounds The TurboVap Il is suitable for evaporation of large volumes after liquid liquid
32. le Processing Manifold Biotage VacMaster 96 Vacuum manifold for processing 96 well SPE SLE or filtration plates Part Number Description Qty 121 9600 VacMaster 96 Sample Processing Manifold 1 without vacuum control Vacuum Control Options 121 9601 VacMaster VCU 1 Vacuum Control Unit 1 121 9602 VacMaster VCU 2 Vacuum Control and 1 Generation Unit 96 Well Collection Plates Deep Well 121 5202 Collection plate 1 mL 50 121 5203 Polypropylene Square well 2 mL 50 Replacement Parts Part Number Description Qty 121 9612 VacMaster 96 replacement gasket 1 121 9613 VacMaster 96 replacement o ring 1 _ Collection plate spacer 2 mm elia for deep well collection plates 121 9610 Array insert 6 mm acetal ED 1 _ Collection plate spacer 29 mm ie for shallow well collection plates izaen VacMaster 96 insert 12 mm for i shallow skirt plates Biotage 2014 2014 Analytical Sample Preparation Catalog Sample Processing Accessories Biotage VacMaster Drying Adaptor Connect to laboratory air or nitrogen supply to dry 10 or 20 SPE columns simultaneously Part Number Description Qty 124 1001 VacMaster 10 Drying Adaptor 1 for 1 3 amp 6 mL columns 124 2001 VacMaster 20 Drying Adaptor 1 for 1 3 amp 6 mL columns Biotage VacMaster Trap Kit Connect between VacMaster 10 20 or 96 and vacuum source to collect waste 1L volume Part Number Descriptio
33. le or dual configurations Heated gas flow ensures faster evaporation especially for high boiling point solvents Biotage SPE Dry Individual control for upper and lower sections Biotage Modular design for easy swap between different nozzle configurations Easy adjustment of nozzle heights for optimal evaporation conditions for all plates Deep or Shallow 24 48 96 and 384 well Plates Biotage SPE Dry 96 and SPE Dry 96 Dual Sample Concentrators are suitable for evaporation of micro plate samples across a broad range of formats By delivering heated gas above and below each well SPE Dry 96 systems dry samples quickly maintaining tight temperature control at user selected settings Designed for high throughput sample processing SPE Dry systems have simple front panel controls and use removable gas delivery assemblies for fast adjusting and cleaning Versatile Formats SPE Dry is designed with novel technology and a simple interface to produce uniform and reproducable evaporation The design has a small footprint to fit easily in the fume hood The heating mechanism is designed to rapidly heat without overshooting the temperature preventing degradation of temperature sensitive compounds Standard SPE Dry 96 and SPE Dry 96 Dual systems are supplied with stainless steel needles For high purity work or applica tions that require particularly aggressive solvents PTFE coated needles are available Both need
34. le types can be individually replaced should they become damaged or corroded SPE Dry is available in single or dual format and adapts easily to 24 48 96 and 384 well microplate formats Solvent Evaporation Fast Reliable and Affordable Biotage 2013 Biotage SPE Dry Advantages wee as 8 Specifications Efficient evaporation through heated gas p 5 i 5 Technology Heated gas delivery above and flow above and below collection plate below wells speeds evaporation Precise temperature control and gas flow Number of samples Models for one or two 96 well with reproducible evaporation times plates Format 8 x 12 well microplates and deep Compact design well plates Easy to use Timer Manual Suitable for 24 48 96 and 384 well microplates Max sample volume 10 mL collection plates Final endpoint volumes Capacity 24 48 96 or 384 well plates Water bath temperature 60 C upper head 80 C lower head Gas supply requirements 1 bar to 4 1 bar 15 psi to 60 psi Gas flow Operating flow rate 25 L to 100 L per minute LPM Exhaust Electrical supply 220 240 V 50 Hz 5 A UK amp EU 100 120 V 50 60 Hz 5A USA amp JP Max power consumed 405 VA Dimensions WxDxH 25 4 cm x 38 1 cm x 40 cm dual NOM Ket od za 24 2 cm x 30 6 cm x 40 cm single ONS ex ex Ae Weight 13 9 kg 31 Ibs Certifications EN61326 1997 w A1 98 amp A2 01 Class A Evaporation Rates minutes Solvent Metha
35. ls only N A C47811 C47816 Tubes C44941 125 pieces and 125 caps are included with purchase of this rack Tubes not included with purchase of this rack Cap type Screw Cap Flip Cap Screw Cap Flip Cap Max recommended Vol 1 5 mL 1 5 mL 2 mL 2 mL LV rack part number C48929 C48928 C48929 C48928 Test tube part number N A N A N A N A 19 20 Ordering Information TurboVap Il Product 110V AC TurboVap II Concentration Workstation with 200 mL tubes and 1 0 mL stems 110 120V Includes set of glassware 6 ea auxiliary rack for holding tubes 12 5 of 2 diameter duct hose clear bath and operator s manual TurboVap II Concentration Workstation with 200 mL tubes and 0 5 mL stems 110 120V Includes set of glassware 6 ea auxiliary rack for holding tubes 12 5 of 2 diameter duct hose clear bath and operator s manual TurboVap II Concentration Workstation with 50 mL tubes and 0 5 mL stems 110 120V Includes set of glassware 12 ea auxiliary rack for holding tubes 12 5 of 2 diameter duct hose clear bath and operator s manual TurboVap II Concentration Workstation with 50 mL tubes and 1 0 mL stems 110 120V Includes set of glassware 12 ea auxiliary rack for holding tubes 12 5 of 2 diameter duct hose clear bath and operator s manual 220V AC TurboVap II Concentration Workstation with 200 mL tubes and 0 5 mL stems 220V Includes set of glassware 6 ea auxiliary rack for holding t
36. lumn Qty Type 120 1031 A ISOLUTE Frit 6 mm A 1 mL 100 4 diameter 20 um PE 120 1032 G ISOLUTE Frit 6 mm G XL 100 4 diameter 20 um PE 120 1033 B ISOLUTE Frit 9 mm B 3 mL 100 3 8 diameter 20 um PE 120 1034 H ISOLUTE Frit 9 mm H XL 100 3 8 diameter 20 um PE 120 1035 C ISOLUTE Frit 13 mm 1 2 C 6 mL 100 diameter 20 um PE 120 1036 D ISOLUTE Frit 16 mm s D 15 mL 100 diameter 20 um PE 120 1037 E ISOLUTE Frit 20 mm E 25 mL 100 13 16 diameter 20 um PE 120 1038 F ISOLUTE Frit 27 mm F 70 mL 100 11 16 diameter 20 um PE ISOLUTE Filtration Columns ISOLUTE Sodium Sulfate Drying Cartridges Pre fitted with two 20 um polyethylene frits Use as standalone filters or stacked above an SPE column Dry organic solvents with this easy to use format contains 2 5 g of high purity sodium Part Number Description Qty 120 1021 A ISOLUTE double fritted filtration column 100 sulfate per cartridge Stack beneath SPE 1 mL 20 um PE columns during elution for efficient in line 120 1022 B ISOLUTE double fritted filtration column 100 1 3 mL 20 um PE solvent drying 120 1023 C ISOLUTE double fritted filtration column 100 6 mL 20 um PE Part Number Description Qty 120 1024 H ISOLUTE double fritted filtration column 50 802 0250 M ISOLUTE Sodium 50 10 mL 20 um PE 120 1025 D ISOLUTE double fritted filtration column 100 15 mL 20 um PE 120 1026 E ISOLUTE double fr
37. n Qty 121 2095 VacMaster trap kit complete 1 Biotage VacMaster Large Volume Extraction LVE Kit For unattended loading of large volume samples Inert PTFE tubing prevents sample contamination f ff fi NT il H 2 Part Number Description Qty a e ai gt 121 2090 VacMaster LVE kit complete 1 mu Fa AT 4 r 4 LI for 1 3 and 6 mL columns Biotage 2014 53 54 Gravity Rack Gravity Rack Process up to 20 samples simultaneously under gravity Part Number 123 2016 123 2019 Accessories 121 0009 121 0001 121 0002 121 0003 121 0004 Biotage 2014 Description Gravity Rack with 16 mm collection tube rack Gravity Rack with 19 mm collection tube rack Universal PTFE stopcock PTFE stopcock needle unit PTFE needle unit Stainless steel needle Stainless steel needle retainer Qty 10 10 10 20 10 2014 Analytical Sample Preparation Catalog Sample Preparation Accessories Accessories For SPE and Filtration ISOLUTE Column Adaptors ISOLUTE Depth Filter Reservoirs Column adaptors attach empty reservoirs filtration columns Reservoirs with pre fitted depth filters remove particulate and depth filters to SPE columns matter from aqueous samples and prevent column blockage Also allow for separate analysis of particulate Part Number Description Qty 120 1100 PTFE Adaptor 1 3 amp 6 mL and XL 10 columns A B C G amp H compounds Part Numbe
38. nol 14 28 11 20 Water 90 165 46 86 Methanol water 50 50 46 95 28 56 Propan 2 ol 16 5 26 145 16 5 Acetonitrile water 50 50 51 60 31 36 Methanol acetonitrile 50 50 19 24 12 ES Acetonitrile 17 20 12 15 5 Methanol v v 1 NH4OH 18 28 155 16 DMF 73 105 33 41 Methanol dichloromethane 50 50 12 1515 7 5 9 5 Dichloromethane v v 1 NH4OH 8 5 11 5 6 8 1 Experiments were conducted with flow rate at 50 liters minute at the upper manifold and 30 liters minute at the lower manifold Drying gas used was compressed air Only standard moisture trap was used within the system Moisture content of ambient air will affect results 2 Temperatures refer to the upper head Bottom unit was 20 C higher 3 500 uL volumes were in a 1 mL collection plate 4 1 mL volumes were in a 2 mL collection plate 13 Access to eight built in methods Optional syringe pump used when re dissolving Biotage V 10 Evaporator Volume Range 1 mL to 12 mL The Biotage V 10 solvent evaporation system rapidly dries samples dissolved in both aqueous and organic solvents up to 20x faster than traditional rotary or centrifugal evaporators A patented combination of drying techniques including high speed vial rotation uniform IR controlled heating and vacuum drying allows for both rapid evaporation and low temperature evaporation of high boiling solvents Pre defined evaporation methods have been optimized to protect the sample against overheating
39. nt 12 case Evaporation tube 50 mL 1 mL endpoint 12 case Evaporation tube 50 mL 0 5 mL endpoint 12 case Evaporation tube 50 mL centrifuge 12 case TurboVap 500 Product TurboVap 500 100 120V 50 60Hz TurboVap 500 200 220V 50 60Hz Vials Evaporation tube 500 mL 1 mL endpoint 2 pk Evaporation tube 500 mL 0 5 mL endpoint 2 pk Evaporation tube 500 mL flat bottom 2 pk Spare Parts TurboVap 500 condenser 1 pk TurboVap LV Product TurboVap LV 110V rack not included TurboVap LV 220V rack not included ASE compatible TurboVap LV 40 60 mL vial 110V ASE compatible TurboVap LV 40 60 mL vial 220V TurboVap LV ASE Upgrade Kit TurboVap LV PTFE bath manifold 50 pos vial 120V TurboVap LV PTFE bath manifold 50 pos vial 220V Vials Test Tubes 10 x 75 mm uncapped 1000 case Test Tubes 12 x 75 mm uncapped 1000 case Test Tubes 13 x 100 mm uncapped 1000 case Test Tubes 16 x 100 mm uncapped 1000 case Test Tubes 16 x 125 mm uncapped 1000 case Test Tubes 20 x 150 mm uncapped 500 case Test Tubes 10 mL conical capped 125 case Test Tubes 15 mL conical capped 125 case Test Tubes polypropylene snap caps for 15 mL conical bottom tubes 500 case Solvent Evaporation Fast Reliable and Affordable Biotage 2013 Part Number C128506 C128507 C128511 C128508 C128512 Part Number C103202 C103203 C128515 C128510 C128514 C128509 Part Numb
40. ntly clean extracts required for today s sophisticated analytical instruments and regulatory bodies The Validation Plan defines the methods and the documentation utilized in the development execution and reporting of a validation for a RapidTrace It addresses installation operation and performance qualification This comprehensive document This means that software control of the system can be enables operators to meet GLP GMP and GOP requiremets bypassed and methods will not be altered during routine operation Labs around the world find this useful in production mode When using magnetically encoded racks the method does not have to be initiated via the controller software because the module reads the magnets and automatically knows which method to run The module runs the number of samples corresponding to the number of sample test tubes placed in the rack gt cre Last Modified frierzo1o 7 59 47AM 16 2010 7 39 47 AM 7 39 47 AM Run Time Eee set vitD set TR Ne RON NK ln ln Increase throughput by controlling up to 10 RapidTrace systems with single computer using the intuitive method development software ss ss sr ses sljels ss sl slslsls KE 3 Instruments a Accessories Racks There are several racks available utilizing the unique magnetic encoding system e 13 x 100 mm fraction sample 12 x 75 mm fraction tube e 13 x 100 mm fraction sample 13 x 100 mm fraction tube e 16 x 100
41. or bumping whilst still maintaining maximum evaporation speed 20 C condenser captures solvent vapors Automatic condenser drain reduces maintenance Optional peristaltic pump for large sample volume transfer Master of Versatility The versatility of V 10 enables rapid evaporation of single samples up to 12 mL or larger pooled volumes by using the V 10 integrated pumps The carousel accessory enables unattended evaporation of up to 16 samples V 10 is the ideal system for evaporation of solvents from prep HPLC fractions Speed up your analysis step with rapid evapora tion directly into a suitable vial for down stream processing Fractionate directly into vials compatible with the V 10 or pool up the fraction racks and use our automation software Control Centre to integrate the entire evaporation process With the use of a liquid handling robot the instrument can combine multiple fractions samples from different test tube racks and dry them into a single vial in one operation Solvent Evaporation Fast Reliable and Affordable Biotage 2013 With the patented technology in V 10 users can rapidly remove high boiling solvents like water DMSO or even NMP at mild temperatures This ensures rapid evaporation without overheating delicate samples Since compounds are dried directly in a vial of choice tedious tasks such as sample transfers handling and reformatting are minimized increasing productivity in the lab
42. overies This unique design allows for partially populated racks to be used without sacrificing extraction efficiency Isolera Spektra One Four LS Isolera is a family of flash purification systems with intelligent features that enable chemists to easily achieve better separations at scales from milligrams to over 150 g The new Isolera Spektra enables chemists to purify more compounds in less time and reduce post process purity analysis Isolera Spektra doubles chemists productivity while slashing purification costs with 20 or more Accessories 17 TurboVap LV Tubes and Racks Chart Match Your Tube to the Outline and Order the Corresponding Rack or Tubes Dimensions mm Scale 1 1 Maximum recommended volume LV rack part number Test tube part number Packsize 20 x 150 30 mL C44282 C40709 250 16 x 125 16 x 100 15 400 125075 Razze 16 mL 12 mL 7 mL 4 mL 4 mL C45269 C44139 C45286 C44577 C48950 C45273 C40708 C40707 C44651 C48985 250 250 250 250 250 Solvent Evaporation Fast Reliable and Affordable Biotage 2013 Tube Matching Guide Snap cap reference nr Kimble 73837 Biotage part number C44942 case of 500 112_ See Er ns Tube reference number Kimble 45165 Kimble 73790 Corning 8080 Kimble 73785 Biotage 47816 Max recommended volume 15 mL 15 mL 15 mL 10 mL 15 mL LV rack part number C44880 C44880 C44880 C47820 C47818 Test tube part number N A C44941 via
43. r Description Qty 120 1101 PE Adaptor 1 3 amp 6 mL 10 columns A B amp C 120 1003 CD RCE depi 100 ilter 6 m 120 1102 PE Adaptor 15 amp 25 mL 10 columns D amp E 120 1009 FD ISOLUTE depth 50 120 1103 PE Adaptor 70 mL O 10 hiter ZO mi column F 120 1104 PTFE Adaptor 6 mL 6 10 Glass columns 4 S 1 SE ISOLUTE Column Caps Seal prepared columns samples loaded columns or immunoaffinity columns for transportation or storage Part Number Description Column Qty Type 1201 0120 Bottom Luer cap All 100 fits all columns 1201 0121 A Top cap 1 mL column A 100 1201 0122 B Top cap 3 mL column B 100 1201 0123 C Top cap 6 mL column C 100 1201 0125 H Top cap 10 mL G amp H 100 XL column 1201 0126 D Top cap 15 mL column D 100 1201 0127 E Top cap 25 mL column E 100 1201 0128 F Top cap 70 mL column F 100 46 Biotage 2014 2014 Analytical Sample Preparation Catalog Accessories For SPE and Filtration ISOLUTE Empty Reservoirs Stack above SPE columns to increase the reservoir volume Part Number Description Qty 120 1001 A ISOLUTE Reservoir 1 mL 100 120 1002 B ISOLUTE Reservoir 3 mL 100 120 1003 C ISOLUTE Reservoir 6 mL 100 120 1006 D ISOLUTE Reservoir 15 mL 100 120 1007 E ISOLUTE Reservoir 25 mL 100 120 1009 F ISOLUTE Reservoir 70 mL 50 e ISOLUTE Frits 20 um porosity sintered polyethylene frits to fit all SPE column sizes Part Number Description Co
44. rmance 2 Reagent mixing chamber allows automated online reagent blending in the method Positive pressure stepper motor syringe pump delivers precise flow rates Compatible with 1 3 and 6 mL version SPE columns Fast and Easy Method Development with Easy to Use Software Utilizing the familiar Microsoft Windows interface operators can easily implement a structured rational strategy for method development to determine optimum processing conditions for each sample The methods can be written in minutes and recalled in seconds Optimization of processing conditions is possible in a fraction of the time compared with conventional manual techniques Column formats reagents concentrations and flow rates can be thoroughly explored as the system allows for incremental manipulation of any parameter eg pH solvent concentration cartridge type flow rate etc in order to determine effects on recovery and precision Operators can insert delete or manipulate steps and easily adjust parameters Methods can be assigned to an individual sample or by module The methods stored in the RapidTrace controller can be easily transferred to other RapidTrace workstations Additionally methods can be saved and run concurrently or true unattended multi method sample processing This unique and rational method design capability dramatically speeds the development of rugged and reliable methods Instruments
45. rt Number C103263 C103264 Part Number EV10 1SX EV10 1PX EV10 1DX EV10 1SC EV10 1PC EV10 1DC EV10 2SX EV10 2PX EV10 2DX EV10 2SC EV10 2PC EV10 2DC EV10 3SX EV10 3PX EV10 3DX EV10 3SC EV10 3PC EV10 3DC Product Accessories Ordering Information Part Number 4 mL vial upper adapter kit 5 pcs type A 8 5 mm 410647 neck inner diameter 4 mL vial upper adapter kit 5 pcs type B 11 1 mm neck inner diameter 4 mL vial upper adapter kit 5 pcs type C 12 0 mm neck inner diameter 4 mL vial lower adapter kit 2 pcs type A 14 8 mm vial diameter 4 mL vial lower adapter kit 2 pcs type B 14 1 mm vial diameter 4 mL vial lower adapter kit 2 pcs type C 16 3 mm vial diameter Start up kit Gilson GX 271 also 215 222 V 10 carousel vial holder 20 mL V 10 carousel vial holder 4 mL 14 5 mm type A B V 10 carousel vial holder 4 mL 16 5 mm type C Gilson GX 271 liquid handler for V 10 Biotage SPE Dry 96 Product Single Plate SPE Dry 96 Dual Heat Source DHS NA 110V SPE Dry 96 Dual Heat Source DHS EU 220V Dual Plates SPE Dry 2x96 Dual Heat Source DHS NA 110V SPE Dry 2x96 Dual Heat Source DHS EU 220V Additional configurations are available Please co representative for more information Accessories Single Plate Spare upper needle head assembly with 96 straight needles PTFE coated Spare upper needle head assembly with 384 straight needles PTFE coated
46. the use of up to 5 x 1 mL or 3 mL columns in the 6 mL turret NORTH AMERICA 1 800 446 4752 EUROPE Note 6 mL columns are only compatible with the 6 mL model see below for upgrade information Part Number C133966 40 mL rack upgrade with sensor Service visit required to install and upgrade the instrument to run the new 40 mL sample rack Kit includes software and one rack Part Number C133967 6 mL Turret upgrade kit Service visit required to upgrade existing RapidTrace 3 mL instruments with the new 6 mL compatible turret Kit includes software and adapters for 1 mL and 3 mL columns Part Number C133969 46 18 56 57 10 JAPAN 81 3 5627 3123
47. ubes 12 5 of 2 diameter duct hose clear bath and operator s manual TurboVap II Concentration Workstation with 200 mL tubes and 1 0 mL stems 220V Includes set of glassware 6 ea auxiliary rack for holding tubes 12 5 of 2 diameter duct hose clear bath and operator s manual TurboVap II Concentration Workstation with 50 mL tubes and 0 5 mL stems 220V Includes set of glassware 12 ea auxiliary rack for holding tubes 12 5 of 2 diameter duct hose clear bath and operator s manual TurboVap II Concentration Workstation with 50 mL tubes and 1 0 mL stems 220V Includes set of glassware 12 ea auxiliary rack for holding tubes 12 5 of 2 diameter duct hose clear bath and operator s manual ASE Versions ASE compatible TurboVap II Concentration Workstation to accommodate 40 mL 1 0 mL Dionex tubes 110 120V Includes auxiliary rack for holding tubes 12 5 of 2 diameter duct hose clear bath and operator s manual ASE compatible TurboVap II Concentration Workstation to accommodate 40 mL 1 0 mL Dionex tubes 220V Includes auxiliary rack for holding tubes 12 5 of 2 diameter duct hose clear bath and operator s manual TurboVap II ASE Upgrade Kit Part Number C103187 C103186 C103188 C103189 C103190 C103192 C103193 C103194 C103196 C103197 C64676 Product Vials Evaporation tube 200 mL 1 mL endpoint 12 case Evaporation tube 200 mL 0 5 mL endpoi
48. und of results e Improved quality precision accuracy and sensitivity e Consistency of preparation e Compliance with regulatory requirements contents page e Improved safety e Quick response to peak or unexpected work loads RapidTrace Advantages Specifications Accessories amp Related Products N OF UW HR W Upgrades Ordering Information 7 LL Biotage biotage com sampleprep Closed fluid path system with segregated waste lines maintain integrity of sample if by Eight solvent reagent lines for maximum methods flexibility Magnetically encoded racks of routine samples RapidTrace Intuitive SPE Automation Rapid Automated Sample Preparation for Routine Processing and Method Development The RapidTrace is designed for advanced processing and the rapid development of rugged sample preparation methods It is extremely reliable and precise incorporating easy to use features for quick method optimization RapidTrace has been successfully implemented in a variety of laboratories all over the world The Biotage RapidTrace eliminates manual sample processing bottlenecks so that analysts can realize the full benefits of today s powerful analytical instruments RapidTrace is the perfect compliment to highspeed analytical techniques a powerful high throughput workstation dedicated to unattended automated sample preparation The enhanced RapidTrace broadens usability and increases instrument perfo
49. use samples Food and beverage analysis Pharmaceutical biotech compounds Clinical samples Remote locations Evaporation Rates Specifications Technology Number of samples Timer range Max sample volume Evaporation rate Final endpoint volumes Solvent reclamation Water bath temperature Gas supply requirements Exhaust Minimum operating pressure Electrical supply Max power consumed Dimensions WxDxH Weight Certifications Solvent Pate VOLE Bath temp C Fan speed rpm 100 38 4000 100 38 6000 Dichloromethane 100 38 8000 180 38 4000 180 58 6000 50 58 6000 100 58 6000 Hexane 180 58 6000 500 58 6000 Methanol 100 58 6000 Acetone 100 56 6000 Acetonitrile 100 58 6000 Acetone hexane 50 50 100 58 6000 Water 100 75 8000 Methanol water 50 50 100 58 8000 Chiller temp TurboVap 500 Gas vortex shearing technology 2 1 to 99 minutes 500 mL Adjustable based on water bath temperature fan speed and chiller or tap water temperature Selectable Automatic endpoints of 0 5 mL and 1 0 mL or dryness 95 of solvent vapors under typical conditions Ambient to 95 C upper temperature with sensors is 60 C Internal fan 4000 8000 rpm No external gas required No gas required 220 240 V 50 Hz 5 A UK amp EU 100 120 V 50 60 Hz 10 A USA amp JP 900 VA 61 cm x 30 2 cm x 53 6 cm 24 x 11 9 x 21 2 18 4 kg 40 5 Ibs 2006 95 EC Low Voltage Directive 2004 108 EC E
50. will alert you when your samples are ready 50 standard or 24 ASE version nozzles Applications TurboVap LV is commonly used for evaporation of solvents following solid phase extraction clean up of drug samples or pesticide extracts It is ideal for sample volumes of 1 mL to 30 mL that need to be evaporated in GC vials microcentrifuge tubes conical bottom tubes or test tubes It offers a high throughput solution with 50 sample positions using the standard range of Biotage racks TurboVap LV can be used in conjunction with the RapidTrace Automated SPE workstation that collects extracts in 12 x 75 mm 13 X 100 mm or 16 x 100 mm test tubes For acidic solutions Biotage offer PTFE coated nozzles to prevent corrosion For volumes greater than 30 mL an ASE compatible version of the TurboVap LV is available for use in conjunction with Dionex ASE 200 columns Dionex ASE is a registered trademark of Dionex Thermo Fischer Solvent Evaporation Fast Reliable and Affordable Biotage 2013 TurboVap LV Evaporation Rates 10 mL solvent Specifications Solvent Bath temp re Approx Technology Gas vortex technology C psi time min Number of samples 50 Gas control Gas can be turned on to each of five independent manifolds when working Hexane 50 12 11 with fewer than fifty samples Gas 60 12 7 regulator and gas gauge range from 35 12 55 O to 20 psi 0 to 2 bar 50 12 32 Timer range 1 to 99 minutes 0 1 to 9 9
51. ynthesis reactions the unique Biotage V 10 Evaporator offers a speedy solution for both HPLC fractions and high boiling solvent removal Its automatic capabilities makes the V 10 Evaporator a work horse for today s drug discovery industries In clinical and hospital labs general sample preparation is common practice and together with our ISOLUTE and EVOLUTE products we offer a complete solution for everyday evaporation and sample preparation needs TurboVap LV can accommodate a variety of sample sizes and formats to adopt your most common work practices In the environmental field larger samples and low concentra tions are often big hurdles TurboVap Il and TurboVap 500 offer a complete solution for both concentrations into smaller volumes or complete evaporation prior to analysis Other product and company names mentioned herein may be trademarks or registered trademarks and or service marks of their respective owners and are used only for explanation and to the owners benefit without intent to infringe System Overview Biotage Evaporation System Selection Guide Sample Sample 3 Capacity Volume Bey Applications TurboVap II 6 50 mLor Food water soil and 200 mL environmental solvent extraction TurboVap II 6 40 mL Food water soil and ASE version environmental solvent extraction 50 From 1 5 Forensic clinical chemistry mL to 30 food and pharmaceutical mL laboratories for concentration of solvents
52. z C103203 TurboVap 500 220 240V 50 60Hz TurboVap 96 C103263 TurboVap 96 100 120V C103264 TurboVap 96 220 240V TurboVap II C103186 TurboVap II 200 mL with 0 5 mL Endpoint Stem 100 120V C103187 TurboVap II 200 mL with 1 0 mL Endpoint Stem 100 120V C103188 TurboVap II 50 mL with 0 5 mL Endpoint Stem 100 120V C103189 TurboVap II 50 mL with 1 0 mL Endpoint Stem 100 120V C103190 TurboVap II 200 mL with 0 5 mL Endpoint Stem 220 240V C103192 TurboVap II 200 mL with 1 0 mL Endpoint Stem 220 240V C103193 TurboVap II 50 mL with 0 5 mL Endpoint Stem 220 240V C103194 TurboVap II 50 mL with 1 0 mL Endpoint Stem 220 240V C103196 TurboVap II 40 mL Dionex ASE Vial Compatible 100 120V C103197 TurboVap II 40 mL Dionex ASE Vial Compatible 220 240V TurboVap LV C103198 TurboVap LV without Racks 100 120V C103199 TurboVap LV without Racks 220 240V C103200 TurboVap LV ASE 40 60 mL vial 100 120V C103201 TurboVap LV ASE 40 60 mL vial 220 240V C112175 TurboVap LV PTFE 50 position 100 120V C133718 TurboVap LV PTFE 50 position 220 240V C55941 TurboVap LV PTFE Coated Upper Manifold Replacement Kit C109301 TurboVap LV Assy Water Bath PTFE Coated Tube Racks C48950 Tube Rack for 10 x 75 mm tubes P N C48985 250 tubes included C44577 Tube Rack for 12 x 75 mm tubes P N C44651 250 tubes included C45286 Tube Rack for 13 x 100 mm tubes P N C40707 250 tubes included C44139 Tube Rack for 16 x 100 mm tubes P N C40708 250 tubes included C452
53. zing the easy to use interface it is simple to implement a structured rational strategy for optimum SPE conditions in experiments Readily transferable methods Methods stored in the RapidTrace controller can be instantly recalled and transferred to other units with 100 confidence Instruments y Vacuum Manifold Manual The improved throughput and workflow has been noted by customers reporting a 92 reduction in analyst time and a 72 reduction in extraction time for a 75 sample extraction comparing the RapidTrace procedure against a manual vacuum manifold a Analyst Time Extraction Time 2 10 Modules 5 Modules Automated Workstation Positive Pressure Syringe Displacement Positive pressure displacement allows for accurate processing and improves reproducibility in flow rate sensitive methods Safety and Security Enclosed working parts ensures operator safety and reduced exposure to solvents and hazardous compounds Additionally password protected control software limits access to methods ensuring method security Combined with magnetically encoded racks run initiation is simplified and the possibility of loading an incorrect procedure is reduced 8 Solvent Inlet Lines Allows for more flexible use of solvents and provides an excellent system for method development Segregated Waste Lines Four segregated output lines allow for easy separation of aqueous organic and biological waste Useful to
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