Micromodulyo freeze dryer manual
Contents
1. Once the process has finished shut down the MicroModulyo as follows 1 If you use a manifold accessory use the manifold valves to vent each flask in turn Remove and seal each flask to protect the dried contents from atmospheric moisture 2 Switch the vacuum pump OFF 3 If you use other accessories slowly open the drain valve to admit air to the system 4 Remove the product when the system has reached atmospheric pressure 5 Switch OFF the MicroModulyo 6 Remove the drying accessory 4 7 DEFROST THE MICROMODULYO WARNING Do not touch any part of the condenser chamber during or immedi ately after the cooling process The condenser chamber is a very low tempera ture and can cause tissue damage WARNING Do not pour water at a temperature greater than 50 C into the ice condenser when it is cold This may result in a dangerous rise in pressure in the refrigeration system Leave the MicroModulyo switched off at ambient temperature to defrost it Make sure that all water is drained from the condenser chamber before you switch the MicroModulyo on again This method takes up to five hours to complete depending on ambient temperature 16 4 7 DEFROST THE MICROMODULYO cont d Alternatively you can pour warm water into the ice condenser to speed up the defrost ing process This method is useful if you wish to use the MicroModulyo again imme diately Use the following procedure 1 Remove the drying accessory from the a2. Section Prepare the MicroModulyo Fit the product container and any other necessary accessory Pre cool the MicroModulyo Dry the product Shut down Table 4 Sequence of operation Before freeze drying a product always prepare the MicroModulyo as described in Section 4 2 Always dry the product and shut down the MicroModulyo as described in Sections 4 5 and 4 6 However the order in which the remaining steps are carried out depends on the type of product container or other accessory used and on the type of product to be freeze dried In some circumstances you will need to pre cool the MicroModulyo with the accessory flange open to atmosphere in other circumstances fit the product contain er then pre cool the MicroModulyo and then load the product to be freeze dried If the correct sequence of operations to follow is not clear refer to the instruction man ual supplied with the product container or other accessory you will use 12 4 2 PREPARE THE MICROMODULYO Note Use only mild detergents to clean the condenser chamber accessories and connecting pipeline Some of the Thermo Scientific accessories are made from acrylic materials and must not be cleaned with organic solvents Before you first use the MicroModulyo and between freeze drying cycles prepare the MicroModulyo as follows T Turn the drain valve fully counterclockwise to open the valve and to remove any water left in the bottom of the condenser chamber When
3. is because the evaporation rate from the product is initially high If the lamp does not go on again within a few minutes the MicroModulyo is overloaded Reduce the amount of product in the freeze drying system to prevent the product from melting If using the MicroModulyo as a vapor trap for a different process restrict the flow of vapor from the connected apparatus to correct the overload e If you wish to dry a number of flasks first attach one flask then evacuate the flask If the operating temperature lamp goes off wait until itis on again then attach and evacuate the remaining flasks in the same way This allows temperature and vacuum levels to recover between each flask 15 4 5 DRYING contd If you use this procedure you can identify any flasks that leak This procedure also prevents rapid pressure increases which might cause flasks to fall off the drying accessory e If there appears to be a leak check that the drain valve is fully closed and that all seals are clean If the MicroModulyo continues to leak contact Thermo Scientific or your distributor 4 6 SHUTDOWN CAUTION If you use a manifold assembly do not admit air into the MicroModulyo through the drain valve until all flasks have been removed oth erwise the flasks may fall off the manifold valves Look at the appearance of the product and consult data gathered from previous freeze drying operations to determine when the freeze drying process has finished
4. 00 Isolation valve F05643000 61 GLASSWARE AND CONNECTIONS Accessory Item number Wide mouth flasks and accessories 1000 ml F05657000 500 ml F05650000 300 ml F05658000 Flask lid includes adapter F05659000 Flask lid filters 100 pk F05659222 Cone connector kit to attach other vessels F05651000 Replacement O rings for Flask lid 25 pk Vials and sealing accessories H02125020 B 2 ml vial 288 pk H01430008 5 ml vial 288 pk H01430048 10 ml vial 100 pk H01430042 Stopper 13 mm for 2 ml vials 1000 pk H01430121 Stopper 20 mm for 5 and 10 ml vials 1000 pk H01430122 B Aluminum seal 13 mm for 2 ml vials 1000 pk H01430161 Aluminum seal 20 mm for 5 and 10 ml vials 1000 pk H01430162 Crimper 13 mm for 2 ml vials H01430203 Crimper 20 mm for 5 and 10 ml vials H01430204 6 2 CONVENIENCE ACCESSORIES Install the MicroModulyo on a convenience cart for easy mobility Add a vacuum gauge between condenser and pump to monitor system conditions during a run Accessory Item number Convenience cart CC120 DX Digital vacuum gauge 50 Torr 10 millitorr DVG50 115 115 V 60 Hz DVG50 230 230 V 50 Hz 19 6 3 VACUUM PUMP AND ACCESSORIES Thermo Scientific high vacuum pumps are suitable for use with the MicroModulyo These pumps are also suitable for freeze drying products which contain sodium azide Vacuum pump accessories are also available Please contact customer services or your supplier to discuss your vacuum pump requirem
5. ER AND OTHER ACCESSORIES A drying accessory may be connected to the MicroModulyo accessory flange Accessories have a rubber sealing ring to seal the accessory to the flange Once positioned the weight of the accessory is sufficient to produce an airtight seal under vacuum conditions The accessory flange has a diameter of 229 mm which is com patible with all the small diameter accessories in the Modulyo product range 4 8 PRE COOL THE MICROMODULYO WARNING Do not touch any part of the condenser chamber during or immedi ately after the cooling process The condenser chamber is at very low temper ature and can cause tissue damage Pre cool the MicroModulyo condenser chamber as follows 1 Switch the MicroModulyo ON 2 Leave the MicroModulyo on until the operating temperature lamp goes on 3 Wait 5 minutes longer before operating 4 5 DRYING CAUTION Use gas ballast on the vacuum pump when drying If you do not water may condense in the pump 1 On Thermo Scientific vacuum pumps install the Gas Ballast Oil Return Kit GBORK referring to its instructions On other manufacturer s pumps fully open the gas ballast valve refer to the pump instruction manual 2 Switch the pump ON Take note of the following when freeze drying products Only switch on a heated accessory when the pressure is 1 mbar or less When a load is first applied to the MicroModulyo the operating temperature lamp may go off for a few minutes This
6. MicroModulyo 2 controls the operation of the valve in the drain pipe The drain pipe is used to drain liquid condensate from the chamber and to admit air into the system A vacuum pipeline connects the chamber to a vacuum pump connector 4 on the front of the MicroModulyo You can connect a vacuum pump to this connector to evacuate the condenser chamber and produce the high vacuum necessary for freeze drying 1 pt ilis if 3p L l 2 1 Accessory flange 3 Drain outlet 2 Drain valve 4 Vacuum pump connector Figure 1 The MicroModulyo Freeze Dryer 1 3 THE BAFFLE TUBE A baffle tube is supplied with the MicroModulyo The baffle tube is installed inside the condenser chamber to extend the vacuum pumping pipeline further into the condens er chamber This results in an improved distribution of ice The baffle tube must be used when a load capacity of 1 liter or more will be collected to ensure an open path for vapor flow within the condenser 4 1 4 CONTROL PANEL AND CONNECTIONS Refer to Figure 2 The controls and connection points of the MicroModulyo are all positioned on the front panel Use of controls and connections is described in Table 1 Control connection On off switch Operating Temperature lamp Drain valve Drain outlet Vacuum pump connector This is a rocker action switch position O off position I on This green lamp goes on when the MicroModulyo has reached its o
7. Part of Thermo Fisher Scientific Instruction Manual Thermo Scientific MicroModulyo Freeze Dryer pe Table of C ontents Section Section Title Introduction Page 1 0 Description 3 11 The MicroModulyo 3 1 2 The Condenser Chamber 4 1 3 The Baffle Tube 4 1 4 Control Panel and Connections 5 1 5 Protection Devices 6 1 6 Applications 6 1 7 The Freezing Process 6 1 8 The Drying Process 6 7 Section Section Title Specifications Page 2 0 Specifications 7 2 1 Refrigeration System 7 2 2 Electrical Data 7 7 3 Construction Materials 7 2 4 Vacuum Pump Requirements 8 2 5 Legislation and Standards 8 Section Section Title Installation Page 3 0 Installation i 8 9 3 1 Connect the MicroModulyo to the Electrical Supply 9 32 Connect the Vacuum Pum 9 3 3 Connect a Thermo Savant High Vacuum Pump to the MicroM odulyo 10 34 Pump Outlet Safety 11 3 5 Test After Installation 11 Section Section Title Operation Page 4 0 Operation 12 4 1 Sequence of Operation 12 4 2 Prepare the MicroModulyo 13 14 4 3 Fit the Product Container and Other Accessories 5 4 4 Pre Cool the MicroM odulyo 5 4 5 Ding 15 16 4 6 Shut Down 16 4 1 Defrost the MicroModulyo 16 17 4 8 Operating with No Load 17 Section Section Title Maintenance Page 5 0 Maintenance 18 5 1 Safety 18 5 2 Precautions 18 5 3 Refrigerant Leaks 18 Section Section Title Drying Accessories Page 6 0 Drying Accessories 19 6 1 Glassware and Connections 19 6 2 Conve
8. Some factors which affect the freeze drying process are described in the following sec tions 1 7 THE FREEZING PROCESS You must first pre freeze the product prior to placing it on or in the drying accessory The thickness of the ice and hence the product will affect the length of time needed to dry a given sample In general the thickness should be less than 10 mm Rate of freezing can also affect drying times slow freezing rates produce larger ice crystals hence a more porous cake which dries more quickly 1 8 THE DRYING PROCESS When the condenser has reached its operating temperature 40 C the operating temperature lamp goes on and the vacuum pump can be switched on see Sections 3 3 and 4 5 The pressure in the condenser chamber then starts to drop producing the conditions necessary for freeze drying The time required to dry a given product is determined by a number of factors These include type of product mass and thickness type of container temperature of the product and condenser rate of heat transfer into the product pressure and system performance Freeze drying requires an input of heat energy to the product to change the ice into water vapor When using the MicroModulyo this energy may be absorbed solely from the surroundings or alternatively a heated accessory may be used to supplement this heat input If you use a heated accessory the accessory should not be switched on until the pressure in the condenser
9. ccessory flange Close the drain valve 3 Pour warm water at a maximum temperature of 50 C into the condenser chamber Do not fill the chamber above the level of the vacuum pipeline aperture near top of chamber wall Wait for a few minutes to allow the ice to melt Fully open the drain valve and allow the water to drain from the condenser chamber A piece of tubing can be connected to the drain outlet for easier drainage into a sink or a container 6 Remove the baffle tube Clean and dry both the baffle tube and the inside of the condenser chamber Prepare the MicroModulyo for the next operational cycle as described in Section 4 2 4 8 OPERATING WITH NO LOAD If you operate the MicroModulyo with no load for several hours the internal compo nents get very cold Atmospheric water vapor will then condense onto the cold sur faces and may drip out of the bottom of the MicroModulyo You may therefore see puddles of water under the MicroModulyo which gives the impression that water is leaking from the condenser chamber If you see water dripping out of the MicroModulyo inspect the condenser chamber If there is ice in the chamber the water is probably not leaking from the chamber but is dripping from the cold surfaces inside the MicroModulyo Always check this carefully before you contact the manufacturer or your distributor for advice To avoid this problem we recommend that you shutdown the MicroModulyo if not using it for mor
10. chamber has fallen to 1 mbar 0 76 Torr or lower An accessory vacuum gauge must be used to measure system pressure see Section 6 2 When deciding on the quantity of heat input required or when optimizing the drying cycle for a particular product it is important to observe the physical appearance of the product whenever possible during the drying process If the product has been cor rectly frozen it will usually appear to be uniform in color and compact If the product 6 1 8 THE DRYING PROCESS cont d is uneven in color or if signs of melting and foaming are visible then the product may have been incorrectly frozen or may have undergone some physical change possibly from the application of too much heat A wide range of factors has to be considered when trying to optimize the drying cycle for a given product To assist in this optimiza tion we recommend that you take note of the rate of change of both temperature and pressure within the condenser chamber during the freeze drying process 2 0 SPECIFICATIONS Dimensions H x W x D 305 x 330 x 432 mm 12 x 13 x 17 in Accessory flange diameter 229 mm 9 0 in Weight 27 kg 59 5 Ib Enclosure rating BS 5490 IP 22 Ambient operating temperature range 5 to 24 C Maximum ambient storage temperature 50 C Condenser chamber Ice capacity in 12 hours 1 0 kg 2 2 Ib Maximum ice capacity 1 5 kg 3 3 Ib Operating temperature 50 C Instrumentation On Off switch Rocker swi
11. e front of the MicroModulyo Figure 2 item 5 The connector is suitable for use with a 10 mm inside diameter pipeline We recommend the use of a Thermo Scientific high vacuum pump with the MicroModulyo These pumps are suitable for freeze drying products which contain sodium azides If you do not use a Thermo Scientific pump the pump must meet the requirements spec ified in Section 2 4 To connect another type of pump to the MicroModulyo refer to the instruction manual supplied with the pump 9 3 3 CONNECT A THERMO SCIENTIFIC HIGH VACUUM PUMP TO THE MICROMODULYO To connect a high vacuum pump to the MicroModulyo refer to Figure 3 and use the following procedure 1 Remove the vacuum pump connection kit from its packing material As shown in Table 2 and in Figure 3 the kit contains a short segment of thin tubing 2 adapter fitting 3 and long length of vacuum hose 4 2 Refer to Figure 3 Fit the centering ring and inlet filter assembly 6 to the inlet port of the pump then use the clamp 7 to secure the nozzle connector 5 to the inlet port These items are included with the pump 3 Push the vacuum hose 4 onto the nozzle connector 5 4 Push the short segment of thin tubing 2 onto the vacuum pump connector marked VAC 1 on the front panel of the MicroModulyo CAUTION To ensure a leak free system it may be necessary to install suitable hose clamps at the nozzle and VAC connectors Vacuum pump connect
12. e than three or four hours This is particularly important if you use the unit in a high humidity environment 5 0 MAINTENANCE Note You must obey the maintenance procedures defined in the instruction manuals supplied with your accessories and vacuum pump 5 1 SAFETY WARNING Obey the safety instruction given below and take note of appropriate pre cautions If you do not you can cause injury to people and damage to equipment 5 2 PRECAUTIONS Switch off the MicroModulyo isolate it from the electrical supply and defrost it before you start maintenance Do not touch any part of the condenser chamber during or immediately after the cooling process The condenser chamber is at a very low temperature and can cause tissue damage e Do not pour water at a temperature greater than 50 C into the condenser chamber when it is cold If you do this may result in a dangerous pressure rise in the refrigeration system e Ensure that you do fault finding in a well ventilated area After you have rectified a fault ensure that the electrical installation of the MicroModulyo conforms with your local and national safety requirements It must be connected to a suitably fused and protected electrical supply and a suitable earth ground point 5 3 REFRIGERANT LEAKS The refrigerant used in the MicroModulyo is heavier than air and is an asphyxiant by the displacement of oxygen If a refrigerant leak is suspected place the unit in a well ve
13. entific Inc 275 Aiken Road Asheville NC 28804 United States www thermofisher com 202 3000 01 Rev B
14. ents FDP series vacuum pumps are pre configured with accessories for freeze drying They include EMF10 oil mist filter GBORK gas ballast oil return kit and DDA110DK stainless steel drain kit The LyoPump is an FDP200 pump coupled with VPOF110 vacuum pump oil filter recirculator The filter unit continuously draws oil from the pump filters it to remove acid and particulates and returns it to the pump thus keeping the oil cleaner and extending the interval between pump maintenance Accessory Item number 76 l min vacuum pump 115V 60 Hz with accessories FDP80 115 62 l min vacuum pump 230V 50 Hz with accessories FDP80 230 116 l min vacuum pump 115V 60 Hz with accessories FDP120 115 97 l min vacuum pump 230V 50 Hz with accessories FDP120 230 195 l min vacuum pump 115V 60 Hz with accessories FDP200 115 162 l min vacuum pump 230V 50 Hz with accessories FDP200 230 LyoPump 115 V 60 Hz FDP200 115 VPOF110 115 VLP195FD 115 LyoPump 230 V 50 Hz FDP200 230 VPOF110 230 VLP195FD 230 WEEE Compliance WEEE Compliance This product is required to comply with the European Union s Waste Electrical amp Electronic Equipment WEEE Directive 2002 96EC It is marked with the following symbol Thermo Fisher Scientific has contracted with one or more recycling disposal companies in each EU Member State and this product should be disposed of or recycled through them Further information on our compliance with these Directives the
15. lyo you should also consider ease of access for general use as well as for maintenance and repair work when the external cover may need to be removed 3 1 CONNECT THE MICROMODULYO TO THE ELECTRICAL SUPPLY WARNING Ensure that the electrical installation of the MicroModulyo conforms with your local and national safety requirements It must be connected to a suit ably fused and protected electrical supply and a suitable earth ground point 1 Make sure that the MicroModulyo is suitable for use with your electrical supply voltage and frequency 2 The MicroModulyo115 is supplied with a ready to use 2 meter long 3 core electrical cable The MicroModulyo230 is supplied with the same type of cable which should be connected to an appropriate power plug as shown in Table 3 below 3 Provide a 10 Amp fuse at the electrical supply outlet to protect the MicroModulyo connection Brown Live or Line 1 Blue Neutral or Line 2 Green Yellow Earth ground Table 3 Electrical supply cable connections 3 2 CONNECT THE VACUUM PUMP WARNING f you intend to freeze dry products which contain sodium azide make sure that your vacuum pump and pipeline are suitable for freeze drying these products If they are not suitable there is a severe risk of explosion CAUTION You must use a two stage vacuum pump with the MicroModulyo If you do not the pump will have a short working life Connect your vacuum pump to the vacuum pump connector on th
16. n the MicroModulyo is CFC free All the MicroModulyo components are housed in a steel cabinet which is designed for bench top use The components are described in the following sections See Figure 1 for location of components When used with suitable accessories the MicroModulyo can be used to freeze dry materials in bulk trays round bottomed flasks tubes vials or ampules Alternatively the MicroModulyo can be used as a low temperature vapor trap cold trap that may be attached to an existing evaporation facility A number of drying accessories are avail able from Thermo Savant refer to Section 6 for a full listing 3 1 2 THE CONDENSER CHAMBER The condenser chamber can trap up to 1 5 liters of ice before it needs to be defrost ed amp cleaned It contains a cooling coil which condenses and freezes water vapor to protect the vacuum pump The temperature of the cooling coil under normal operating conditions with no load applied is approximately 50 C A 229 mm diameter accessory flange 1 is at the top of the condenser chamber All Modulyo drying accessories with small flange approx 215 mm diameter are com patible The large chamber top opening allows easy inspection cleaning and defrost ing of the condenser chamber and enables high vacuum pumping rates to be attained A valved drain pipe runs from the base of the condenser chamber to the drain outlet 3 on the front of the MicroModulyo The drain valve on the front of the
17. nience Accessories 19 6 3 Vacuum Pump and Accessories 20 1 0 1 1 DESCRIPTION This manual provides installation operation and maintenance instructions for the Thermo Scientific MicroModulyo Freeze Dryer The MicroModulyo must be used as spec ified in this manual Read this manual before installing and operating MicroModulyo Important safety infor mation is highlighted as WARNING and CAUTION instructions you must obey these instructions The use of WARNINGS and CAUTIONS are defined below WARNING Warnings are given where failure to observe the instruction could result in injury or death to people CAUTION Cautions are given where failure to observe the instruction could result in damage to equipment associated equipment and process In accordance with the recommendations of IEC1010 the following warning symbols may appear on the freeze dryer Caution refer to accompanying documents Caution risk of electric shock Caution hot surface gt gt gt THE MICROMODULYO The MicroModulyo is the ice condenser section of a freeze drying system It is a low cost unit suitable for freeze drying biological research materials and preparations in a laboratory The MicroModulyo requires only the attachment of a pump and a drying accessory for samples to form a complete freeze drying system The MicroModulyo has a condenser chamber a refrigeration system and a control sys tem with temperature indicator The refrigerant used i
18. ntilated area Do not allow naked flames or smoking near the MicroModulyo as products of combustion of the refrigerant include dangerous fluorides and chlorides If refrigerant vapor is inhaled summon medical help immediately Take the victim to a well ventilated uncontaminated area If the victim s breathing is weak or has stopped apply artificial ventilation preferably using an oxygen resuscitator Do not use adren aline or other cardiac stimulants At normal atmospheric pressure the refrigerant will evaporate at 40 C Contact with skin or eyes can cause cold burns If contact has taken place seek medical help immediately and carry out the following Remove clothing from the affected area care fully irrigate the affected area with tepid water for at least 15 minutes apply a sterile dressing and treat the wound as you would a heat burn 18 6 0 ACCESSORIES Accessory Item number 8 port Column manifold F05656000 Bell jar F02960000 Work table F02305065 Vial Cell stoppering shelf F05623000 Heater kit for stoppering shelf 230 V 50 Hz F05655000 Heater kit for stoppering shelf 115 V 60 Hz F05655115 Spin Freezer 96 230 V 50 Hz F05637000 Spin Freezer 96 115 V 60 Hz F05637115 Secondary drying manifold single column F02964000 Secondary drying manifold additional column F02956000 Secondary drying manifold double column F02965000 Cold trap adapter NW40 connections F05660000 Pipeline attachment F02305082 Adapter flange F056260
19. one di sostanze soggette alla Direttiva RoHS sono disponibili sul sito www thermo com Conformit WEEE Ce produit doit tre conforme la directive euro p enne 2002 96EC des D chets d Equipements Electriques et Electroniques DEEE Il est marqu par le symbole suivant Thermo Fisher Scientific s est associ avec une ou plusieurs compagnies de recyclage dans chaque tat membre de l union europ enne et ce produit devrait tre collect ou recycl par celles ci Davantage d informations sur laconformit de Thermo Fisher Scientific ces directives les recycleurs dans votre pays et les informations sur les produits Thermo Fisher Scientific qui peuvent aider le d tection des substances sujettes la directive RoHS sont disponibles sur www thermo com Great Britain Lid Deutschland lx Italia Lx France Lx Important For your future reference and when contacting the factory please have the following information readily available Model Number Serial Number Date Purchased The above information can be found on the dataplate attached to the equipment If available please provide the date purchased the source of purchase manufacturer or specific agent rep organization and purchase order number IF YOU NEED ASSISTANCE SALES DIVISION Phone 1 866 984 3766 866 9 THERMO LABORATORY PARTS and SERVICE Phone 1 800 438 4851 TECHNICAL SUPPORT Phone 1 800 438 4851 Thermo Fisher Sci
20. or VAC Thin tubing Adapter Fitting Vacuum hose Nozzle connector Centering ring and inlet filter assembly Clamp Thermo Scientific Pump UE ee Supplied with Thermo Scientific pump Figure 3 Connect a Thermo Scientific high vacuum pump to the MicroModulyo 10 3 4 PUMP OUTLET SAFETY Fit an oil mist filter or pipe the exhaust gases of the vacuum pump to a suitable chem ical fume hood All Thermo Scientific FDP high vacuum pumps are supplied with a gas ballast oil return kit GBORK and EMF10 oil mist filter Refer to specific manuals received with your pump 3 5 TEST AFTER INSTALLATION CAUTION Do not attempt to use the MicroModulyo if it fails the installation test If you do poor performance may result in the loss of the product being freeze dried When you have installed the MicroModulyo use the following procedure to test that it works correctly 1 2 Turn the unit ON Watch the cooling fan through the grill on the side of the MicroModulyo If the fan rotates then it is operating correctly continue at Step 3 If the fan does not rotate continue at Step 5 below Check that the compressor operates If it operates you will hear a low hum continue at Step 4 If you cannot hear the compressor continue at Step 5 below Leave the MicroModulyo on for approximately 30 minutes then check that the operating temperature lamp is on If the lamp is on the MicroModulyo is ready for use If the lamp i
21. ou move it Use proper lifting technique lift with the knees not the back to avoid personal injury Unpack and inspect Remove all packing materials and inspect the MicroModulyo If damaged notify your supplier and the carrier in writing within three days state the item number of the MicroModulyo together with your order number and your supplier s invoice number Retain all packing materials for inspection Do not use the MicroModulyo if it is damaged Check that your package contains the items listed in Table 2 below If any of these items is missing notify your supplier in writing within three days MicroModulyo Baffle tube Thin tubing Adapter fitting Vacuum hose Table 2 Checklist of components If the MicroModulyo is not being used immediately replace the protective covers Store the MicroModulyo in a clean dry area until ready for use 3 0 INSTALLATION cont d Site Preparation The MicroModulyo is designed for use on a laboratory benchtop Locate the MicroModulyo in its required operating position within convenient access to a suitable electrical supply A MicroModulyo system may also be set up on a mobile cart such as Thermo Scientifics CC120 DX Deluxe Convenience Cart We recommend that you leave an air gap of at least 8 inches between all four sides of the MicroModulyo and any wall or obstruction If you do not leave a sufficient air gap poor cooling may result in poor performance When you locate the MicroModu
22. perating temperature When closed this valve isolates the condenser chamber from the drain outlet When open this valve is used to admit air into the vacuum system and also to drain water from the condenser chamber after defrosting This outlet is used to drain water from the MicroModulyo during defrosting of the condenser chamber and cooling coil The outlet is also used to admit air into the vacuum system Use this to connect your vacuum pump to the MicroModulyo Table 1 Controls and connections MicroModulyo Freeze Dryer Q oo 3 4 1 Operating Temperature lamp 2 On Off switch 3 Drain Valve Thermo Scientific 4 Drain outlet 5 Vacuum Pump Connector Figure 2 Front Panel 5 1 5 PROTECTION DEVICES The MicroModulyo is protected by a thermal magnetic circuit breaker which is integral to the on off refrigeration switch You must manually reset the switch when the circuit breaker trips The electrical supply to the MicroModulyo must be suitably fused refer to Section 3 1 1 6 APPLICATIONS If you want to use the MicroModulyo as a freeze dryer you must connect it to a two stage vacuum pump and attach a drying accessory When you use the MicroModulyo as part of a freeze drying system we recommend that you keep accurate records of all operating parameters sample load drying times and so forth This data will help you to determine the optimum cycle for efficient operation with various products
23. recyclers in your country and information on Thermo Scientific products which may assist the detection of substances subject to the RoHS Directive are available at www thermo com WEEE Konformitt t Dieses Produkt muss die EU Waste Electrical amp Electronic Equipment WEEE Richtlinie 2002 96EC erf llen Das Produkt ist durch folgendes Symbol gekennzeichnet Thermo Fisher Scientific hat Vereinbarungen getroffen mit Verwertungs Entsorgungsanlagen in allen EU Mitgliederstaaten und dieses Produkt muss durch diese Firmen widerverwetet oder entsorgt werden Mehr Informationen ber die Einhaltung dieser Anweisungen durch Thermo Scientific dieVerwerter und Hinweise die Ihnen n tzlich sein k nnen die Thermo Fisher Scientific Produkte zu identizfizieren die unter diese RoHS Anweisungfallen finden Sie unter www thermo com Conformit WEEE Questo prodotto deve rispondere alla direttiva dell Unione Europea 2002 96EC in merito ai Rifiuti degli Apparecchi Elettrici ed Elettronici WEEE E marcato col seguente simbolo Thermo Fischer Scientific ha stipulato contratti con una o diverse societ di riciclaggio smaltimento in ognuno degli Stati Membri Europei Questo prodotto verr smaltito o riciclato tramite queste medesime Ulteriori informazioni sulla conformit di Thermo Fisher Scientific con queste Direttive l elenco delle ditte di riciclaggio nel Vostro paese e informazioni sui prodotti Thermo Scientific che possono essere utili alla rilevazi
24. s not on continue at Step 5 If any of the above steps fail switch the MicroModulyo off disconnect from electrical supply and contact Thermo Scientific or your distributor 4 0 OPERATION WARNING If you intend to freeze dry products which contain sodium azide make sure that your vacuum pump and pipeline are suitable for freeze drying these prod ucts If they are not suitable there is a severe risk of explosion Sodium azide is sometimes used as a stabilizing agent in freeze drying processes Sodium azide is toxic and when dry is highly explosive If you freeze dry a product which contains sodium azide a chemical reaction can occur in the presence of heavy metals such as copper lead zinc and cadmium The result of this reaction is the formation of metallic azides which are highly unstable and explosive The MicroModulyo contains no heavy metals and is suitable for freeze drying products which contain sodium azide The Thermo Scientific high vacuum pumps are also suit able for this purpose However if you do not use a Thermo Scientific pump your vacuum pump and vacuum pipeline may not be suitable for freeze drying products containing sodium azide Check with your vacuum pump manufacturer to determine its suitability if you intend to freeze dry products containing sodium azide 4 1 SEQUENCE OF OPERATION Operation of the MicroModulyo can involve a number of different steps as shown in Table 4 below Operation step Refer to
25. tch with thermal magnetic circuit breaker Operating temperature lamp Remote sensing thermostat 2 1 REFRIGERATION SYSTEM Refrigerant type ISCEON 69L R403a Refrigerant change 96 3 3 4 oz Expansion device capillary tube 2 2 ELECTRICAL DATA MicroModulyo 230 MicroModulyo 115 Nominal electrical supply 220 240V 110 120V 1 phase 1 phase Electrical supply frequency 50Hz 60Hz Protection Internal Thermal magnetic circuit breaker rated at 3A 8A External 10 A fuse 10 A fuse 2 3 CONSTRUCTION MATERIALS Item Material Cabinet Steel Condenser chamber Stainless steel Vacuum pipeline Stainless steel Baffle tube Nylon 2 4 VACUUM PUMP REQUIREMENTS For freeze drying your vacuum pump must meet the following specifications Type of pump Two stage oil sealed rotary pump Ultimate pressure lt 5 x 10 mbar 3 8 x 10 Torr Pumping rate 30 l min or more Recommended pump Thermo Scientific FDP series high vacuum pump Note Your vacuum pump must have a gas ballast facility to prevent water build up in the pump FDP series pumps include oil filter and gas ballast oil return kit and are specifically configured for the freeze drying application 2 5 LEGISLATIONS AND STANDARDS The MicroModulyo has been designed in compliance with the following legislation and standards CE Directives 3 0 INSTALLATION WARNING The MicroModulyo is heavy Do not attempt to lift it without suitable lifting equipment or someone to help y
26. the chamber is completely drained turn the drain valve fully clockwise to close it If acidic corrosive products have been processed flush through the condenser chamber and drain line with clean water Make sure that the condenser chamber is dry Make sure that the MicroModulyo is clean particularly the accessory flange If the flange is not clean you will not get a good vacuum seal and the performance of the MicroModulyo will be poor Check the vacuum connection on the front of the MicroModulyo Check the connection at the vacuum pump Refer to Figure 4 Install the baffle tube by placing it over the drain outlet in the center of the condenser chamber The cut outs in the tube must be at the bottom If you do not fit the baffle tube the vacuum pump connection may become blocked with ice this may cause a loss of vacuum and the product may melt Use of the baffle tube is required especially when more then 1 liter of ice is processed Select a suitable drying accessory for the product Wipe clean the sealing ring of the accessory and check the sealing ring for damage if it is damaged fit a new sealing ring The accessory sealing ring should not need lubricating but if itis excessively dry apply a light wipe of high vacuum grease 4 2 PREPARE THE MICROMODULYO cont d 1 Accessory flange 3 Drain outlet 2 Baffle tube 4 Condenser chamber Figure 4 Fit the baffle tube for distribution of ice 14 4 3 FIT THE PRODUCT CONTAIN
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