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NE-500 OEM Syringe Pump User Manual

1. Syringe Size Inside Maximum Minimum Maximum Manufacturer mL Diameter Rate Rate Rate all names i mm mL hr uL hr AimnL min B D 1 4 699 53 07 0 73 0 884 3 8 585 177 1 2 434 24952 5 11 99 345 5 4 748 5 758 10 14 43 500 4 6 876 8 341 20 19 05 872 2 11 99 14 53 30 21 59 1120 15 4 18 67 601 26 59 1699 23 35 Il 28 32 HSW HE 4 69 52 86 0 727 0 881 Norm Ject 3 9 65 223 8 3 076 3243 5 12 45 3312 5 5 119 6 209 10 15 59 607 6 8 349 10 12 20 20 05 966 2 13 28 16 1 30 22 9 1260 lTs32 21 50 29 2 2049 28 16 I 34 15 Monoject 1 5 74 79 18 1 088 1 319 3 8 941 192 1 2 64 3 202 6 123 7 387 6 5 326 6 46 12 VESTE 593 9 8 161 9 899 20 20 12 972 9 13 37 16 21 35 23 52 1329 185 27 22 15 60 26 64 1705 23 44 28 42 140 38 3470 47 69 57 84 Terumo 1 4 7 53 09 0 73 0 884 3 8 95 192 5 2 646 3 208 5 13 406 1 5 581 6 769 10 15 8 600 8 244 10 20 20 15 975 8 13 41 16 26 30 223451 1282 17 63 21733 60 29 2120 29 13 LL 35 33 Poulten amp 1 6 7 107 8 1 483 1 798 Graf 2 8 91 190 8 2 622 3 18 Glass 3 9 06 197 2 2s TLI 3 288 5 11 75 331 8 4 559 Dios 10 14 67 517 2 7 107 8 62 20 19 62 9255 2 12 72 15 42 30 22 69 12317 17 01 20 62 50 26 96 1746 24 01 29 11 Steel 1 9 538 218 6 3 005 3 644 Syringes 3 9 538 218 6 3 005 3 644 5 1247 387 6 5 326 6 46 8 9 538 218 6 3 005 3 644 20 19 I3 879 5 12 09 14 65 wl 29 6 1965 27 0111 32 76 g Size Inside Maximum Minimum size Inside Maximum Minim
2. Non volatile memory of all operating parameters and Pumping Program Publication 1200 02 Audible Alarm Many more features 09 18 14 New Era Pump Systems Inc www SyringePump com Model NE 500 NE 501 Multi Phaser 2 1 Glossary of Terminology and Concepts When a device has as many features as the NE 500 NE 501 understanding its operation could be a daunting task at first By understanding the key concepts and terminology used in this manual the operation of the NE 500 NE 501 will become quite intuitive Every effort has been made to design the NE 500 NE 501 with a consistent and intuitive user interface To facilitate and enhance your understanding of the NE 500 NE 501 s operation please take the time to familiarize yourself with the basic concepts below 2 3 4 5 6 Parts of the Pump End Plate 7 Syringe Retainer Bracket Anti Siphon Plate Adjustment Knob 8 V Slot on Syringe Holder Block Drive Nut Button 9 Syringe Holder Block Anti Siphon Plate 10 Syringe Clamp Drive Screw 11 Guide Rod 2 guide rods Syringe Retainer Thumbscrew 2 one on each side 12 Pusher Block Parts of a Syringe Plunger Flange Publication 1200 02 3 09 18 14 New Era Pump Systems Inc Terminology Pumping Program Pumping Program Operating Pumping Program Stopped Pumping Program Paused Pumping Program Resumed Executed Program Phase Phase Number Currently Selected Function Pu
3. Event Square Wave function will be triggered causing the Pumping Program to continue execution at the Phase number defined in the Event function If an Event Trap has not been defined then the Pumping Program continues execution at the next program phase This is useful if the pump is executing a continuous infusion phase The pump can continue to infuse until a foot swtich is pressed The pumping program can then jump to a different phase such as a withdraw phase then stop the pump The Trigger Event Trap is a one time function After triggering an Event Trap the Trigger Event Trap is cleared The Trigger Event function will not affect the current trigger configuration 7 3 22 Set TTL Output Pin Command FUN OUT n Set Program Output TTL I O output pin 5 to level n If n 0 the output pin will be set low If n 1 the output pin will be set high 7 3 23 Set TTL Expansion Port Output Pin Low Command FUN OEO expansion pin gt Set expansion port pin expansion pin to logic level 0 7 3 24 Set TTL Expansion Port Output Pin High Command FUN OE1 expansion pin gt Set expansion port pin expansion pin to logic level 1 7 3 25 Beep Command FUN BEP Sounds a short beep Publication 1200 02 17 09 18 14 New Era Pump Systems Inc www SyringePump com Model NE 500 NE 501 Multi Phaser 7 4 Pumping Program Examples 7 4 1 Example 1 2 Step Rate ml hr Rate 30 ml D
4. Function Rate 1 0 J t Q Function Iz y o Volume 0 1 mL Function Rate 1 0 10 Z a Function 11 LOP 50 Function 12 JMP 02 7 4 4 Example 4 Complex Dispenses with External Synchronization 2 750 gt T E CD Start Start Syringe Start 5 Trigger Trigger Refill Trigger v L 7 z o id A more complex dispensing example this Program contains different pumping requirements including dispenses with multiple pumping rates The first set of 3 dispenses drops down to a lower pumping rate during the dispense When each dispense is completed the buzzer beeps to alert the operator then the pump waits for a start trigger before starting the next dispense The next set of 3 dispenses have a fixed time interval of 60 seconds between dispenses After the last set of dispenses the syringe is refilled by the amount infused 17 25 mL Then the buzzer beeps to alert the operator to the start of the first set of dispenses The process is then repeated Function Rate RAT 750 0 mL hr Function Rate RAT 300 0 mL hr Function BEP Function PAS 00 Publication 1200 02 20 09 18 14 New Era Pump Systems Inc www SyringePump com Model NE 500 NE 501 Multi Phaser Phase Function 5 LOP 02 Function RAT Function RAT Rate 750 0 mL hr Rate 300 0 mL hr Infuse Function BEP Function LPS Function 10 PAS
5. command enabling Safe Mode would then be in the Safe Mode protocol 8 3 1 RS 232 General Syntax Legend The following syntax expansion legend is common to all syntax expansions Except where indicated all command and response characters are ASCII data float gt f float Floating point number Maximum of 4 digits plus 1 decimal point Maximum of 3 digits to the right of the decimal point volume units gt UL uL microliters ML mL milliliters TTL level gt 1 TTL high level 0 TTL low level lt on off gt gt 1 On enabled 0 Off disabled expansion pin gt 1121314 15 phase data gt n lt n gt count data gt n n number data n n text gt any printable character lt text gt lt f gt gt lt n gt n gt 0111213141516171819 byte gt one byte of any data Publication 1200 02 Expansion port pin Valid values 1 to 5 Program Phase number Valid values 1 to 41 Valid values 1 to 99 Valid values 0 to 99 Floating point digits Digits One byte of data expressed as Oxhh where hh is the data in hexadecimal 27 09 18 14 New Era Pump Systems Inc www SyringePump com Model NE 500 NE 501 Multi Phaser gt Is defined by Syntax expands to next level of expansion lt gt Non terminal syntax expansion Optional syntax Required syntax Or Choose one of the syntax o
6. 5 LPS Function LPS Function 7 PAS 60 Function LOP 60 Function LOP 05 Function 10 LOP 12 Function 11 JMP 01 7 4 7 Example 7 Sub Programs This example shows some of the flexibilities provided by the Program Selection functions The Pumping Program starts by refilling the syringe with 50 mL at a fast pumping rate Phase 1 then the Pumping Program pauses for user sub program selection Phase 3 Then performs 5 dispenses of 10 mL at the selected rates then refills the syringe again and pauses for the next user sub program selection The user selects the sub program from a selector switch that is attached to the Expansion Connector See sec 9 Logic Interface TTL Input and Output The pump is started from a start switch connected to the trigger input TTL I O Pin 2 Up to 32 sub programs can be addressed from the Expansion Connector The user is given the option of choosing one of three defined sub programs 1 Dispense 10 mL at 100 mL hr Phase 4 2 Dispense 10 mL at 500 mL hr Phase 7 3 Dispense 10 mL at 750 mL hr Phase 10 After selecting the sub program and pressing Start the Pumping program continues execution at the selected sub program After the 10 mL dispense each sub program jumps or continues with the loop counter function Phase 12 The first 4 loops continue Program Execution with the next user sub program selection After the 5th loop the program continues with Phase 13 which jumps back to the
7. Function EVN 05 Set Trigger Event Trap to start syringe refill Function Rate Volume 3 RAT 1000 0 mL hr 1 5 mL Direction Infuse Begin bolus dispense Publication 1200 02 25 09 18 14 New Era Pump Systems Inc www SyringePump cOm Model NE 500 NE 501 Multi Phaser Phase Function Rate Volume Direction RAT 500 0 mL hr 0 0 mL OFF Infuse Then infuse continuously Function Rate 5 FIL 1000 0 mL hr Refill syringe when foot switch is released Function STP Then stop the pump 8 RS 232 Communications The NE 500 NE 501 Syringe Pump can communicate with any computer software aM package or device with an RS 232 communications port Em Emw In 8 1 Connection and Networking OA Ll the side of the pump are 2 square RJ 11 phone jack style sockets Connect the RS 232 cable into the socket labeled Computer Connect the other end to the serial port on the computer or other control device Turn power off to the pump and the computer before connecting cables If the pump is part of a pump network connect a pump network cable between the socket labeled Pump Network on the first pump and the socket labeled Computer on the next pump in the network Repeat for each pump in the network connecting the Pump Network socket of one pump to the Computer socket on the next pump in the network Up to 100 NE 500 NE 501 pumps can be network together al
8. Reversed Rising edge stops the Pumping Program RL 8 Start on Low Level Start Pumping Program on a low level RH 9 Start on High Level Start Pumping Program on a high level SL 10 Stop on Low Level Stop Pumping Program on a low level SH 11 Stop on High Level Stop Pumping Program on a high level OF 12 Trigger off Disable trigger Et 13 Trigger Event Pumping Program Function Only Stop Trigger triggers an event instead of stopping the pump Bt 14 Button Trigger Event Pumping Program Function Only Pressing Stop key triggers an event instead of stopping the pump 6 6 TTL I O Directional Control Input Configuration Command DIN n Configures how the TTL input Pumping Direction pin 3 will control the pumping direction See sec 9 1 TTL I O Operational Controls Setting n Mode Function Reciprocating Pumps Falling edge Infuse Rising edge Withdraw Used for 2 pumps operating in opposite directions 1 Dual Pump Falling edge Withdraw Rising edge Infuse Used with 2 pumps operating in the same direction Publication 1200 02 10 09 18 14 New Era Pump Systems Inc www SyringePump cOm Model NE 500 NE 501 Multi Phaser The setting names are relevant to a 2 pump system whereby the Directional Control Input TTL pin is attached to the second pump s Pumping Direction Output TTL pin In addition Directional Control Input will affect how the Sticky Direction functi
9. are set according to the diameter setting NOTE A change in the volume units will affect all Volume to be Dispensed settings in the Pumping Program If the default volume units are changed see next section the selected volume units will remain in effect until a reset function is performed From 0 1 to 14 0 mm Syringes smaller than 10 mL Volume units are uL From 14 01 to 50 0 mm Syringes greater than or equal to 10 mL Volume units are mL 5 1 2 Changing Volume Units The volume units used for accumulated volumes and the Volume to be Dispensed settings can be changed to either mL or uL A change in the volume units will affect all Volume to be Dispensed settings in the Pumping Program Set the volume units command VOL MLIUL The selected volume units will remain in affect and override the default volume units Changing the diameter will no longer change the volume units Performming a system reset FRESET will cancel the override and allow the volume units to change to the default volume units when setting the syringe diameter 5 2 Start Stop Triggers Start Command RUN Stop Command STP The Pumping Program can be started or stopped from different sources The RUN and STP commands or the TTL I O Operational Trigger input Each can control the Pumping Program s operation 5 3 Operating the Pump When a start trigger is received the Pumping Program begins to operate starting w
10. current Phase function is RATE and the next Program Phase s function to be executed is not Increment FUN INC or Decrement FUN DEC Also while pumping rate units cannot be set The new pumping rate will only be stored in non volatile memory if the Pumping Program is not operating When the pumping rate is queried while pumping the response will be the current pumping rate and units Otherwise the response will be the rate setting and units if applicable With the Increment and Decrement functions these two responses are not the same RAT C float rate units Allows the Pumping Program to continue after the pumping rate is changed The RAT C command will not clear a Paused Pumping state after the rate is changed when the Pumping Program is paused Normally the Pumping Program would re start from Phase 1 after the rate is changed while paused RAT I float rate units Changes the pumping rate only if the pump is infusing If the pumping direction is set to withdraw the rate change will be ignored VOLUME TO BE DISPENSED AND SET VOLUME UNITS VOL float volume units gt Set query volume to be dispensed float Applicable only with Rate Data Functions Can only be set when the Pumping Program is not operating The volume units are set according to the current syringe diameter setting Do not send the volume units when setting the volume Example VOL 12 45 Sets the current phase Volume
11. n Lock out mode Sets Auto Run mode with Sub Programs BP n Notification beep mode where n is the current setting Publication 1200 02 8 09 18 14 New Era Pump Systems Inc www SyringePump com Model NE 500 NE 501 Multi Phaser 6 1 RS 232 Pump Network Configuration Command ADR nn B baud rate lt RECP gt DUAL ALTR The pump can be configured to communicate either with a computer or another pump Communications with a computer Address Mode is the default setting and will be indicated by setting an address from 0 to 99 When in the default Address Mode up to 100 pumps can be attached to a computer in a single pump network The network address is defined by the 2 digits parameter nn If only one pump is attached to the computer set the network address to 0 ADR 0 which is the factory default Additionally the baud rate can be set with this command For details see the detailed RS 232 command section Special communications modes ADR RECP Reciprocating Pumps Sends Start Stop Pumping rate and reverse pumping direction to an attached secondary pump ADR DUAL Reciprocating Pumps Sends Start Stop Pumping rate and same pumping direction to an attached secondary pump ADR ALTR Alternating pump mode When pump stops start signal sent to secondary pump Note Communications with a computer requires the accessory cable CBL PC PUMP 7 Communications with a sec
12. of O This will simplify communications because the address can be left off the commands sent to the pump To set the network address individually attach each pump to the computer Disconnect the network cable from the Network connector on the pump Using the ADR nn command send a unique address to each pump from 0 to 99 This operation only has to be performed once The set address will be stored in the pump s non volatile memory and will take effect immediately Once the set address command is sent the pump will only respond to commands sent to the set address To query a pump s current network address send the command ADR without any parameters The pump will respond with its current pump address in the response packet s data field Publication 1200 02 26 09 18 14 www SyringePump com Model NE 500 NE 501 Multi Phaser New Era Pump Systems Inc 8 3 RS 232 Protocol When the pump is used in a multi pump network configuration precede each command with a pump address Pumps will ignore all commands that do not have their defined network address If the network address is not specified in the command the address will default to 0 After a command is sent to the pump the pump will not accept any further communications until the current command has been processed Completion of the command processing is indicated when the first byte of the response packet is transmitted Communications to and from the pump use the follow
13. pin lt expansion pin gt The trigger is the detection of a high to low TTL transition on the specified pin or a low level when the function is first executed 7 3 18 Setup Expansion Port Pause and Trigger Edge Wait Phase Command FUN EPE lt expansion pin gt Pauses the Pumping Program and waits for a trigger on Expansion Port pin lt expansion pin gt The trigger is the detection of a high to low TTL transition on the specified pin 7 3 19 Event Reset Command FUN EVR Event Reset cancels a previously set event trap 7 3 20 Clear Total Volume Dispensed Command FUN CLD Sets the total volume dispensed to 0 Both infusion and withdraw volumes are reset 7 3 21 Override Operational Trigger Default Configuration Command FUN TRG lt nn gt Sets the Operational Trigger pin 2 to mode setting lt n gt overriding the default setup Operational Trigger Configuration See Sec 6 5 TTL I O Operational Trigger Default Configuration for the settings for parameter lt nn gt The default setting for the Operational Trigger is always used to start the Pumping Program Publication 1200 02 16 09 18 14 New Era Pump Systems Inc www SyringePump com Model NE 500 NE 501 Multi Phaser 7 3 21 1 Trigger Event Trap Trigger Event Trap Command FUN TRG 13 Trigger Event Trap redirects a stop pump trigger to the background event trap Instead of stopping the pump an event defined by the Event or
14. put the pause function within a Program loop A Program section with the following functions in consecutive Phases FUN LPS FUN LPS FUN PAS 60 FUN LOP 60 FUN LOP 24 will pause the Pumping Program for 24 hours If nn is 00 then the Pumping Program pauses and waits for a start trigger to resume the Program After the start trigger the Program will resume with the next Phase The start trigger can be from any source the TTL I O Operational Trigger or from RS 232 If alarms are enabled the buzzer will beep continuously while waiting for the start trigger 7 3 13 Jump to Phase If External Trigger Command FUN IF nn The IF function conditionally alters the Pumping Program s execution based on an external signal When executed if the TTL I O Program Input pin pin 6 is low level then the Pumping Program continues operation with Phase number nn Otherwise the Pumping Program continues operation with the next Phase 7 3 14 Setup Event Trigger Jump Phase Command FUN EVN nn The Event function sets a background event trap that is triggered by an external signal This one time background trap or interrupt stays set during the Pumping Program s entire execution until it is triggered or reset This function has no other effect on the operation of the pump until it is triggered The event is triggered when either 1 A falling edge high to low TTL transition occurs on the TTL Event Trigger input pin 4 or 2 A l
15. rate needs to be set The operation of the pump can then be started from the TTL I O connector or from RS 232 computer control All data that is set will be stored in the pump s non volatile memory meaning that the new value will not be lost the next time that power is applied to the pump The only exception is when the pumping rate is changed while the Pumping Program is operating In this case the new pumping rate will not be stored in non volatile memory In general numeric data are floating point data consisting of up to 4 digits plus 1 decimal point and is referred to in the command descriptions as float data For example 123 4 12 3 and 12 34 are acceptable formats for floating point data Publication 1200 02 5 09 18 14 New Era Pump Systems Inc www SyringePump cOm Model NE 500 NE 501 Multi Phaser 5 1 Syringe Inside Diameter Set with command DIA lt float gt The syringe inside diameter can only be set while the Pumping Program is stopped Valid syringe diameters are from 0 1 mm to 50 0 mm If the diameter is out of this range the response will be 2OOR Changing the syringe diameter will not zero any current settings Section 10 7 Syringe Diameters and Rate Limits is a representative list for reference of syringe diameters for various syringe manufacturers and syringe sizes 5 1 1 Default Volume Units The units of the accumulated infusion and withdrawal volumes and the Volume to be Dispensed
16. screw ratio Drive screw pitch Power connector Voltage at power connector Amperage Power supply type Dimensions Weight 10 5 2 Operational Maximum speed Minimum speed Maximum pumping rate Minimum pumping rate Maximum force Number of Program Phases RS 232 pump network RS 232 selectable baud rates Syringe inside diameter range 10 6 Custom Applications Publication 1200 02 Up to 60 mL 140 mL partially filled 1 Step motor 400 1 8 to 1 2 depending on motor speed 0 2126 um to 0 8504 um depending on motor speed 15 28 20 revolutions 2 mm center positive DC 12 VDC at full load 800 mA at full load Unregulated linear external wall adapter country and power source specific or compatible regulated power supply 9 1 2 Lx 4 W x 4 1 8 LxWxH 24 13 cm x 10 16 cm x 10 5 cm 2 2 Ibs 1 0 kg 5 1005 cm min 0 004205 cm hr 1699 mL hr with a B D 60 mL syringe 0 73 uL hr with a B D 1 mL syringe 35 lbs at minimum speed 18 lbs at maximum speed 41 100 pumps maximum 300 1200 2400 9600 19200 0 100 to 50 00 mm For specialized and OEM applications contact your dealer or New Era Pump Systems Inc Custom modifications can be made to the mechanics or the firmware 44 09 18 14 New Era Pump Systems Inc www SyringePump com Model NE 500 NE 501 Multi Phaser 10 7 Syringe Diameters and Rate Limits
17. the Program Output TTL line is lowered PHASE 04 sending a synchronization signal to another device The pump then continues to pump at 800 mL hr PHASE 06 until a synchronization signal is received at the Event Trigger TTL input causing the Program to jump to Phase 7 PHASE 05 The pump then withdraws 0 25 mL PHASE 07 pauses for 1 second PHASE 08 then repeats this process if the Program Input TTL line is low PHASE 09 otherwise it continues with the next Phase Next the pump pauses for 10 seconds PHASE 10 Then it pauses again for the lesser of another 10 seconds PHASE 12 or until an Event Trigger occurs PHASE 11 The Program then restarts PHASE 13 Function EVR Function OUT 1 Function Rate Volume Direction 3 RAT 800 0 mL hr 5 0 mL Infuse Function OUT 0 Function 5 EVN 07 Function Rate Volume Direction RAT 800 0 mL hr 0 0 mL Infuse Function Rate Direction RAT 1000 0 mL hr 0 25 mL Withdraw Function PAS 01 Function IF 07 Function 10 PAS 10 Function 11 EVN 01 Function 12 PAS 10 Function 13 JMP 01 7 4 9 Example 9 Automatic Refill While a foot switch is held dispense continuously starting with a 1 5 mL bolus When the foot switch is released the syringe will refill to the volume that was dispensed In the pump s general setup set the TTL Trigger to Foot Switch Hold mode Command TRG FH Function TRG 12 Redirect trigger input to the Event Trap
18. the Expansion Port This command is used in conjunction with the FUN EVN command After setting an event trap with the FUN EVN function the FUN EVE function re directs the event trigger source to pin expansion pin on the expansion port This one time background trap or interrupt stays set during the Pumping Program s entire execution until it is triggered or reset This function has no other effect on the operation of the pump until it is triggered The event is triggered only when a falling edge high to low TTL transition is detected on the expansion port pin expansion pin When triggered the current operation of the pump and the Pumping Program is interrupted and the Pumping Program immediately continues operation jumps to with Phase number nn specified with the FUN EVN function executed prior to the execution of the FUN EVE function After being triggered the event trigger is reset If an event trigger function is executed while another event trap is still set the new event trigger will replace the previous event trap The following example sets an event trap at the start of a Pumping Program to jump to Pumping Program Phase 5 when a falling edge occur on expansion port pin 3 PHN 1 FUN EVN 5 PHN2 FUN EVE 3 7 3 17 Setup Expansion Port Pause and Trigger Level Wait Phase Command FUN EPL lt expansion pin gt Pauses the Pumping Program and waits for a trigger on Expansion Port
19. the command RESET Publication 1200 02 i 09 18 14 New Era Pump Systems Inc www SyringePump com Model NE 500 NE 501 Multi Phaser Table of Contents 1l GENERAL INFORMATIQON 5 e eae enar sao eina nee seo san seo sane e sae ia aseo eene e seo SE nsssessasoosseses 1 1 1 WARNINGS ZN AND CAUTIONS D M 1 1 2 DISCLAIMER istat telato eo eoo sot ese ores oae prose Cue e eae sese se oes o oou soseste S e oe godes o Deo se dee oo EUROPEO SERE UE 1 1 3 VEHIT UR Ls 1 1 4 PACKING LIST eee eeceeeeeenecoeeses Ca eeu ena ee ecee eee eee ees vopo ad ces Ue vao nera e cosssovaevoacseseeseecosovoccsocvess 2 2 OVERVIEW isvsccssssessescacscccssastescccscscccanssnsveccacvsctevessoseccsceccsebesnecseccsseccssosdseseesssecssudeseossscaseseoe 2 2 1 GLOSSARY OF TERMINOLOGY AND CONCEPTS ccssssscssssssssccsscccccssssscscscccesscssssssscccooes 3 3 SETUP srl la ie ana 4 4 LOADING SYRINGES niei cenit cicocdssescssccctstucecscsossssctevecesscssscesveseoacsteessbeccosesoscevesocsaceceess 5 5 OPERATION PREPARES 5 5 1 SYRINGE INSIDE DIAMETER scscescsscacicecesscoscscssessccssteosccasoosecussesaessesoesesesensoccaseondsdsseecocsese 6 Su une neum IUe Se A DEFAULT VOLUME UNITS bu HEP nr TC MP PE CHANGING VOLUME UNITS 5 2 START STOP TRIGGERS sscsscscesssseccsccsscesscsaseccaseseceoscbasceccsesdsosscsasesccseessosssescecetesssesnsbecsees 6 5 3 OPERATING THE PUMP tcsscccccisosscccacsocscssves
20. to be Dispensed to 12 45 Set volume units volume units Overrides the default volume units set when the syringe diameter is set Example VOL UL Sets all volume units to uL Query response float volume units PUMPING DIRECTION DIR INF WDR I REV ISTK Set query pumping direction INF Infuse WDR Withdraw REV Reverse pumping direction STK Sticky Direction Applicable with all Program Phase functions Cannot be set when the Pumping Program is operating and the Volume to be Dispensed is non zero The pumping direction cannot be changed if an alarm condition exists Query response INF WDR ISTK When set to Sticky Direction query will respond with the current pumping direction INF or WDR while pumping Publication 1200 02 32 09 18 14 New Era Pump Systems Inc www SyringePump com Model NE 500 NE 501 Multi Phaser 8 5 2 Pump Operational Commands START PUMPING PROGRAM RUN phase data E phase data Starts the Pumping Program operation If the Pumping Program was paused then the Pumping Program resumes at the point where it was stopped Otherwise the Pumping Program starts from Phase 1 Sub Programs If a Phase number is specified phase data then the Pumping Program will start at the specified Phase number By programming sub programs in different sections of the Pumping Program memory this command can be used to individually execute different
21. uL or mL UL or ML 5 7 Volume Dispensed Volume is computed based upon the syringe inside diameter setting The volume is accumulated separately for infusion and withdrawal The volume dispensed for infusion and withdrawal can be queried with the DIS command Publication 1200 02 7 09 18 14 New Era Pump Systems Inc www SyringePump com Model NE 500 NE 501 Multi Phaser The Volume Dispensed accumulations for infusion and withdrawal are reset to 0 when A The pump is powered on B The syringe diameter is changed C From the RS 232 clear Volume Dispensed command CLD or Clear Dispense function D The accumulated Volume Dispensed rolls over from 9999 to 0 E Asub program is selected when the Pumping Program executes a Sub Program Selection function 5 8 Resuming When Paused If the Pumping Program is stopped before the completion of the Pumping Program the response prompt will change to P indicating that the Pumping Program is paused While paused starting the pump again will resume the Pumping Program where it was stopped This means that the Pumping Program will continue at the point in the Phase where it was stopped and the Volume to be Dispensed will still be referenced from when the Program Phase first started Pause is exited by sending a stop command STP or changing any setting When the Pumping Program is started again it will start from the beginning Phase 1 5 9 Pump Stalled Mod
22. 60 Function Rate 11 RAT 500 0 mL hr 3 75 mL Function 12 LOP 03 Function Rate Volume Direction 13 RAT 900 0 mL hr 17 25 mL Withdraw Function 14 BEP Function 15 PAS 00 Function ui y tH 16 7 4 5 Example 5 Control from a High Low Pressure Sensor Pumping c Rate E C Pressure high sensor Pressure low sensor i lt Pressure trigger points Program Output Pin L 3 3 meg UU y This example demonstrates a Pumping Program whose control depends on an external sensor Assuming a pressure sensor that is configured to detect a high pressure point and a low pressure point the Pumping Program individually selects whether it will react to the high or low pressure point The Program Output pin on the TTL I O connector pin 5 is used to select the high or low pressure point When low the low pressure point is selected PHASE 01 and when high the high pressure point is selected PHASE 05 The Program begins by infusing continuously at 10 0 mL hr PHASE 02 while a background trap is set for the low pressure point PHASE 03 To create a delay when the pressure sensor is switched from high pressure to low pressure when the Program Output pin is set a small volume is pumped PHASE 02 06 before the background traps are set Publication 1200 02 21 09 18 14 New Era Pump Systems Inc www SyringePump com Model NE 500 NE 501 Multi Phaser W
23. 7 foot cable Part CBL PC PUMP 7 25 foot cable Part CBL PC PUMP 25 Cable to connect a pump or the first pump in a pump network to a standard computer s RS 232 serial port with a DB 9 connector A 9 pin to 25 pin converter is available upon request Publication 1200 02 42 09 18 14 New Era Pump Systems Inc www SyringePump com Model NE 500 NE 501 Multi Phaser RS 232 Network Secondary Cable 7 foot cable Part CBL NET 7 25 foot cable Part CBL NET 25 Cable to connect additional pumps after the first pump to the pump network USB to RS 232 Converter Cable USB to RS 232 cable software drivers on CD Part CBL USB232 Attached to the RS 232 Network Primary Cable allows communication through a PC s USB port 10 3 4 Automation Cable Special Communications Modes Control Cable Part CBL DUAL 3 Using two NE 1000 series syringe pumps this cable either creates an automated continuous operation pumping system whereby one pump is refilling while the other is dispensing or creates a dual pumping system with both pumps operating in the same direction This cable is attached to two NE 1000 series syringe pumps via their RS 232 connectors In this setup with the pumps configured for this operation one pump acts as the Master controller With the Master pump programmed with a continuous infusion program the other pump will always be pumping in the opposite direction With proper plumbing this will create a continuous
24. 750 mL hr 2 0 mL Phase Function Rate Volume RAT 750 mL hr 0 25 mL Phase Function LPS Phase Function 4a LPs Phase Function PAS 90 Phase Function s oos Phase Function BEP Phase Function s rs3o Phase Function Rate Volume 19 RAT 750 mL hr 2 25 mL Phase Function Rate Volume RAT 750 mL hr 0 25 mL Phase Function LPE 7 4 3 Example 3 Ramping the Flow Rate Phases M Phases Phases 25 5 8 9 11 o tc x E Time Continuously ramp up and 250 mL hr in 1 0 mL hr ste 150 mL hr in 1 0 mL hr ste Note Graph is representative only Pumping rate increments and decrements in steps down the pumping rate Starting at 200 mL hr the pumping rate will increment to ps after every 0 1 mL has been dispensed Then the pumping rate will decrement to ps after every 0 1 mL has been dispensed Finally the pumping rate is incremented back to 200 mL hr in 1 0 mL hr steps after every 0 1 mL has been dispensed then the process is repeated Function Rate Volume RAT 200 mL hr 0 1 mL Phase Function LPS Phase Function Rate Volume INC 1 0 0 1 mL Publication 1200 02 19 09 18 14 New Era Pump Systems Inc www SyringePump com Model NE 500 NE 501 Multi Phaser Phase Function LOP 50 Function Un y o Function Rate 1 0 Volume 0 1 mL J t Q Function LOP 99 N Volume 0 1 mL
25. 8 UN PETERE EXAMPLE 2 REPEATED DISPENSES WITH SUCK BACK VAD RE Bendis cessed eee A T ENER eee ET e ere s ROT EN ds EXAMPLE 3 RAMPING THE FLOW RATE 7 4 4 EXAMPLE 4 COMPLEX DISPENSES WITH EXTERNAL SYNCHRONIZATION 20 7 4 5 EXAMPLE 5 CONTROL FROM A HIGH LOW PRESSURE SENSOR ce 21 TAO asses iit EXAMPLE 6 AUTOMATED DISPENSING WITH SYNCHRONIZATION JE SE eae A e EA ee Tu E IAN fete deseen e e AE us EXAMPLE 7 SUB PROGRAMS 7 4 8 EXAMPLE 8 DISPENSING WITH COMPLEX SYNCHRONIZATION 24 7 4 9 EXAMPLE 9 AUTOMATIC REFILL ii 25 8 RS 232 COMMUNICATIONS ciciscvsiiezioiscicanezionionezionionezioniRienionionesicnczanicinnenzinio 26 8 1 CONNECTION AND NETWORKING ccssssscscssssccscssssccscssscccccsssccssessnscesesssccssssssecessssces 26 8 2 RS 232 PUMP NETWORK CONFIGURATION cccssssssccssssccccssssccscsssccsssssssescsssssessesssces 26 S 3 RS 232 PROTOCOL e eetossdceue oun suce Uvade sae eu TESTATO Tnt totale esente 27 8 3 1 RS 232 GENERAL SYNTAX LEGEND 27 EROE ROSES Dt t tds ist DITO EGR RS 232 PROTOCOL BASIC MODE 8 993 dr A dees dees sar Ede T acus RS 232 PROTOCOL SAFE MODE 8 3 4 RS 232 PROTOCOL BASIC AND SAFE MODE COMMON SYNTAX cnm 29 8 3 5 NETWORK COMMAND BURST cccccccccccccsesssssssessscccessssssessssccecssesssessssseseesesseeeess 29 8 4 COMMAND ERRORS AND ALARMS e eee ee eene eee eene eee etos sete tense e eee toes sette sees ee en
26. E 501 Multi Phaser New Era Pump Systems Inc 10 Appendix 10 1 RS 232 Command Summary command gt DIA float PHN phase data gt FUN phase function gt lt phase function gt gt Syringe inside diameter Program Phase number Program Phase function RAT Pumping rate FIL Fill syringe to volume dispensed INC Increment rate DEC Decrement rate STP Stop pump PAS lt number data gt Pauses pumping for nn seconds if 0 wait for start trigger PAS n n Pauses pumping for n n seconds JMP lt phase data gt Jump to Program Phase PRI Sub Program Selection Input from expansion connector PRL lt number data gt Sub Program Start Label definition LPS Loop starting Phase LOP lt count data gt LPE IF lt phase data EVN phase data EVS phase data EPL expansion pin EPE expansion pin EVE expansion pin EVR CLD OUT 011 OEO expansion pin OEI expansion pin TRG nn BEP Loop to previous loop start nn times Loop end Phase If Program input low jump to Program Phase Set event trigger Set event square wave trigger Pause program wait for low edge or level on expansion pin Pause program wait for falling edge on expansion pin Re direct event trigger to expansion pin Event trigger reset Clear total dispense volume Set programmable output pin Set expansion pin low Set expansion pin high Override Operational T
27. Note Cable is compatible with USB to RS 232 converter cables Publication 1200 02 4 09 18 14 New Era Pump Systems Inc www SyringePump com Model NE 500 NE 501 Multi Phaser Note on USB If an RS 232 port is not available on your PC the pump may be operated through a USB to RS 232 converter cable available as an accessory part CBL USB232 This cable attaches to the standard RS 232 to PC cable part CBL PC PUMP 7 The PC will create a virtual RS 232 communications port that communicates through the USB to RS 232 converter cable The terminal emulator can communicate through this virtual port Start the PUMPTERM emulator communications program Downloadable from web site Next the Pumping Program can be entered Before the Pumping Program can be operated the pump needs the measurement of the inside diameter in millimeters of the syringe that will be loaded The syringe diameter is entered using the DIA command Finally the syringe can be loaded and the pump started 4 Loading Syringes The syringe is loaded by securing the barrel and the pusher flange as follows 1 Loosen the 2 thumbscrews on the syringe retainer bracket 2 Press in fully the white drive nut button on the pusher block releasing the block Taking care not to drag the drive nut on the drive screw slide the block away from the syringe holder providing sufficient space for the loaded syringe Then release the white button 3 Liftthe syr
28. PCB Query is not applicable TTL INPUT QUERY IN n E 112131415 Expansion Port Connector Queries TTL level of pin on TTL I O connector Set is not applicable n Indicates pin number on TTL I O connector Valid values 2 3 4 and 6 E Reads from the Expansion Port I O connector on the PCB Query response TTL level BUZZER BUZ OI 1 lt n gt Sets queries buzzer Set O Turn buzzer off 1 Turn buzzer on if lt n gt specified If lt n gt 0 buzzer beeps continuously otherwise buzzer beeps lt n gt times if lt n gt not specified buzzer sounds continuously Query response 011 0 Buzzer off 1 Buzzer is on continuously or beeping 8 5 5 System Commands SET PUMP NETWORK ADDRESS AND BAUD RATE ADR address B 19200 9600 2400 1200 300 DUAL RECP ALTR Set query pump network address lt address gt gt lt n gt lt n gt lt address gt Valid range 0 to 99 B 1920019600 2400 12001300 will change the baud rate as indicated NOTE The command response and all further communications will be at the specified baud rate Special communications modes DUAL Sets the pump to Dual Pumping mode with a secondary pump RECP Sets the pump to Reciprocating Pumping mode with a secondary pump ALTR Sets Alternating pumping mode All special communications modes use 19 200 baud rate Publication 1200 02 35 09 18 14 New Era Pump Systems Inc ww
29. Phase is set to one function The set function of the current Phase is the currently selected function Each Pumping Program function instructs the pump to perform a particular operation If the Phase s operation instructs the NE 500 501 to pump then associated with that Phase is the Phases pumping information When a Program Phase is selected the Rate Volume and pumping direction refer to the currently selected Program Phase s function The Program functions that are associated with pumping information are referred to as Pumping Rate functions Certain functions which do not instruct the NE 500 501 to pump require additional data This additional data sent with the function command is the function s parameter The Pumping Program may be started or stopped from multiple sources These are the TTL I O Operational Trigger input or from a command received through the RS 232 connection Place the pump on a stable surface Plug the connector end of the power supply into the power plug located on the PCB on the side of the pump See section 9 Logic Interface TTL Input and Output for a diagram of the connectors on the pump After power is applied to the pump the buzzer will beep Attach the pump s serial port to the computer s serial port using the cable CBL PC PUMP 7 Attach the RJ 11 Telephone connector to the pump s Computer connector Attach the DB 9 connector to the proper connector on the computer
30. Pump Systems Inc SyringePump com SyringePump com Models NE 500 NE 501 Multi Phaser NE 1000 Series of Programmable Syringe Pumps RR EE Retee see eest esee eee FE e LLL LLOTI I OOOO OO OSOONI 50 5 amp 407 230 t 10 0 Ka 0 10 20 30 40 50 60 70 80 90 Time WHAT S YOUR APPLICATION M WARNING NOT FOR CLINICAL USE ON HUMANS Publication 1200 03 Revision 17 V3 919 9 18 14 New Era Pump Systems Inc www SyringePump com Model NE 500 NE 501 Multi Phaser Quick Start Instructions Assumes that the pump was not previous programmed with a multiple Phase Pumping Program e Plug in the pump e Attach the computer cable to the Computer connection on the RJ 11 connector e Start the terminal emulator program on the computer downloadable from the web site Baud Rate 19 200 Data frame 8N1 Default settings for the downloadable terminal emulators e Note Each command sent to the pump must be terminated by a carriage return 0x0D Sent automatically by terminal emulator Space characters are ignored Characters can be upper or lower case e Note Wait for the response from each command before sending the next command Setup Pumping Parameters Set the Syringe Inside Diameter e Where nn nn is the syringe inside diameter in mm Send the command DIA nn nn Set the Pumping Rate e Where nn nn is the pumping rate and xx is th
31. T TTL level OEO expansion pin OEI expansion pin BEP PUMPING RATE RAT CII float rate units Set query pumping rate rate units gt UM MM UH MH Publication 1200 02 Pumping rate Fill syringe to dispensed volume Increment rate Decrement rate Non Rate Control Functions Stop pump Pauses pumping for nn seconds or until trigger if 0 Pauses pumping for n n seconds Loop to previous loop start nn times Loop starting Phase Loop end Phase Jump to Program Phase Override Operational Trigger Default Mode set to nn Conditional Functions If Program input TTL pin low jump to Phase Set event trigger trap Set event square wave trigger trap Pause and wait for expansion pin event edge or level Pause and wait for expansion pin event edge Re direct event trigger trap to expansion pin Event trigger trap reset Clear total dispense volume TTL Logic and Other Functions Set programmable output pin Set expansion pin to 0 low level Set expansion pin to 1 high level Sound short beep uL min mL min uL hr mL hr 31 09 18 14 New Era Pump Systems Inc www SyringePump com Model NE 500 NE 501 Multi Phaser Applicable only with Rate Data Functions When setting the pumping rate if the current Phase s function is not RATE then rate units is not applicable While pumping the pumping rate can only be set if the
32. UDIBLE ALARM ENABLE scccccsscssssssssscccsccssssscsssccccsssssscscssscccesscessssssnccccosscssssscssscoses 9 65 TTL IO OPERATIONAL TRIGGER DEFAULT CONFIGURATION cccccssssssssssscscscccees 10 6 66 TTL I O DIRECTIONAL CONTROL INPUT CONFIGURATION ccccsssssssscccsssssssccsccooes 10 6 7 PUMP MOTOR OPERATING TTL OUTPUT CONFIGURATION cccsssssssscccssssssscesccooes 11 6 8 LOCKOUT MODE si dicesccescsesssesecescascestessedacdocscoasussesdccvecenesseossucscdonssesvussencsCboubsessiesenescboete 11 6 9 NOTIFICATION BEEP MODE ccccccssssssssscccccssssssccssscccessssssssscescccccesesssssccccesssssssscnscooes 11 7 PUMPING PROGRAM sissscsdsescsscsctascesssteseccaccsesesteasaleoseseesnsssaudeceacsteassteesececsssesvessstesoeseee 11 7 1 HOWTO ENTER PUMPING PROGRAMS scccccccssssssscssscccccsssssssccsscccessssssssccccccessssssseees 12 7 2 CLEARING THE PUMPING PROGRAM cccssssssossssssssccscccccsscsssssccccccessssssssssccccessssssceees 12 7 3 PROGRAM FUNCTION DESCRIPTIONS ccssssssssssssssscsscccccsssssssccsscccesssssscscesscccssessssscees 12 UELLE RATE FUNCTION PSD sce eee fe eu AA ee pe eoe Redes doe ever veo e re ea desde v e FILL FILL FUNCTION 7 3 3 INCREMENT RATE FUNCTION cscscccccccccesssssscccccccccessssnncccececeessssnsaceceescessensnaeecs 13 KS iaia iran EN DECREMENT RATE FUNCTION PEE EP EIE STOP PUMPING OPERATION AND END THE PROGRAM Publication 1200 02 ii 09 18 14 New Era Pump Systems Inc
33. VDD n c DB 9 Connector Power teen esteem Connector Network Computer Figure 1 Rear of Pump On the PCB on the bottom of the pump is a DB 9 connector labeled TTL I O which is used for TTL I O The logic signals on this connector permit bi directional control with external equipment In addition an Expansion Connector is available with 5 TTL lines for additional functions To use the expansion connector the PCB needs to be modified as indicated in the diagram above Header pins can be soldered to the PCB to attach a cable Control input TTL logic levels must be held steady for a minimum of 100 ms to be recognized To minimize the possibility of false signals caused by glitches and ringing which could be caused by the closure of mechanical switches TTL control inputs are software filtered With a sampling period of 50 ms glitches of less than 100 ms are filtered out Edge detection requires the detection of a change in TTL levels With a minimum of 100 ms to detect a level an edge requires a minimum of 200 ms to be detected Since the next level change can be detected in 100 ms creating another edge the maximum edge to edge frequency is 10 Hz Edge changes to the Pumping Direction and Operational Trigger inputs must occur at least 50 ms apart Falling edge refers to a logic high to logic low transition Rising edge refers to a logic low to a logic high transition To guarantee recognition of logic levels voltag
34. ception of a valid packet Although the communications time out timer is not enabled the Auto Alarm feature will be enabled Therefore the pump will be in an Auto Alarm only communications mode When power is applied to the pump or if the system should reset a system reset alarm occurs The Auto Alarm feature therefore alerts the host computer that a pump reset has occurred Publication 1200 02 28 09 18 14 New Era Pump Systems Inc www SyringePump com Model NE 500 NE 501 Multi Phaser 8 3 4 RS 232 Protocol Basic and Safe Mode Common Syntax transmitted data gt command data response data command data gt lt address gt lt command gt To pump lt response data gt gt lt address gt lt status gt lt data gt lt command error gt From pump status gt prompt alarm Operational state of pump prompt gt I Infusing W Withdrawing S Pumping Program Stopped P Pumping Program Paused T Pause Phase U Operational trigger wait user wait X Purging alarm gt A alarm type Alarm alarm type gt R Pump was reset power was interrupted S Pump motor stalled T Safe mode communications time out E Pumping Program error O Pumping Program Phase is out of range lt address gt gt lt n gt lt n gt Pump network address 0 to 99 System command overrides network address data gt text Response to command CR gt 0x0D Carriage r
35. currently mL hr send the following command followed by a carriage return CR spaces are optional O rat 100 1 rat 250 2 rat 375 8 4 Command Errors and Alarms If a command received by the pump is not recognized or the data is invalid an error message will be in the data field of the response packet following the prompt field The following are the error responses command error gt error error gt Command is not recognized only NA Command is not currently applicable OOR Command data is out of range COM Invalid communications packet received IGN Command ignored due to a simultaneous new Phase start When an alarm occurs the alarm must be acknowledged before any data is changed or the pump is started Alarms are acknowledged by the user clearing the alarm message on the keypad or the alarm status being sent in response to any valid RS 232 command An alarm message sent automatically in the Safe Mode will not clear the alarm condition This is to verify that the alarm message was sent to a receptive host such as after a power failure when both the computer and the pump were reset In this case the pump will most likely send its reset alarm message before the computer has finished booting 8 5 RS 232 Command Set All data changed from RS 232 is stored in the non volatile memory except for changes to the pumping rate while pumping All Program Phase Data refers to the currently selected Pr
36. decesosoccssseosecacsccsseseccsndecoveseccssbessecscecsesesesecsesese 6 54 PUMPING RATE sscepssssscccasesctsasensdeceatestesegsendeceatessscscestoseteosseonecsseceecedvesesssdvodoceseeesenecsbeceess 7 5 4 1 CHANGING THE PUMPING RATE AND DIRECTION WHILE PUMPING 7 5 5 PUMPING DIRECTION se eei eo ese pesa soot ose te o aee sous uade eR TR o Eee posu eve ende PE eoe e nU ees pel E ee ena PUR R Pe 7 5 5 1 STICKY DIRECTION S es eece ee ote eet eerte epe ede eee e eee eee eto ote MEER ree 7 5 6 DISPENSE VOLUME TARGET AND CONTINUOUS PUMPING e esee ee eese esee eee eese eene 7 SO iaia EIE A TE E ET PN T EAEE E SET VOLUME UNITS 5 7 VOLUME DISPENSED e ceti RENI RTRT os eese Pe Cao n Unis oves Eo Ease Uso ena P PE Te eo vus een Eo E Tae sere Ue pad 7 5 8 RESUMING WHEN PAUSED 5 roto eise eon tonta Peso sese ean s nsa oe tae e eee apo a sooo Ta e se eos da creto ei eie EEUU 8 5 0 PUMP STALLED 3 2 RICA aoro aoc e ro Fe eene inb OSSA Vete ee ee visepa Tere SITI RI ARA espe eine cereo te ueeedopdsta 8 6 SETUP CONFIGURATION 5 5555 5 65S ene Suse Sese soe asse caro se asse desee sese Sena sind osee Cac E Taro ve 8 6 1 RS 232 PUMP NETWORK CONFIGURATION cccsssssssscsccssssscsscscccsscsssssccssccesscsssssconccoses 9 6 2 POWER FAILURE MODE oesseseses see esed eese seas eoe esee ease ke Noo aeo eSe see e Ta eee e riss eoa eR eee eua soosi 9 6 35 LOW NOISE MODE oT 9 6 4 A
37. e rate s units Send the command RAT nn nn xx Rate units xx value mL hr MH uL hr UH mL min MM uL min UM e If the pumping rate is out of range the response message to the computer will include OOR Set the Volume to be Dispensed or Continuous Pumping e Where nn nn is the volume to be dispensed send the command VOL nn nn If the volume to be dispensed is 0 then the pump will pump continuously e Note The default units for the volume to be dispensed will be mL or uL depending on the syringe size At or below 14 00 mm syringe diameter volume units are uL Above 14 00 mm syringe diameter volume units are mL The default volume units can be overridden Set the Pumping Direction e For infusion send the command DIR INF For Withdrawal send the command DIR WDR Load the Syringe e Press in the white drive nut button to move the pusher block e Insert the syringe plunger in the pusher block slot e Insert the syringe barrel flange in the flange brackets with the syringe barrel holder on the syringe Tighten the flange brackets onto the syringe flange Tighten the pusher block screw Operating the Pump Start the Pump Send the command RUN Stop the Pump Send the command STP Query the Pump Status e Send just a carriage return to the pump The pump will respond with a status prompt When Pumping e The pumping rate can be changed e With continuous pumping the pumping direction can be changed PUMP RESET send
38. el NE 501 only When the operation of the motor is impeded due to excessive force needed to drive the syringe the pump will stop pausing the Pumping Program and a stall alarm will occur The buzzer will sound continuously if alarms are enabled Also if the RS 232 Safe Mode is enabled an auto alarm message will be sent to an attached computer Sending any command will stop the buzzer and clear the alarm When the problem causing the pump motor to stall has been corrected the Pumping Program can be resumed from any start trigger source TTL input or RS 232 NOTE Pump stall is an error condition and should not be used as a normal method of stopping the pump Continued pump stalling can damage the drive nut block Damage to the drive nut block is not covered by the warranty 6 Setup Configuration The following configuration parameters can be set or queried woe The values for n are 0 for off 1 for on See relevant sections for command definitions Command Description ADR nn Set the pump network address or mode of communications PFn Power Failure mode where n is the current setting LNn Low noise mode to minimize the motor s micro stepping resonance ALn Alarm mode where n is the current setting TRG aa Operational Trigger default configuration where aa is the current configuration DIN n Directional control TTL logic input setup ROM n Pump motor operating TTL logic output configuration LOC
39. er slave protocol whereby the pump transmits in response to a received command But the pump also automatically transmits a status packet when an alarm condition occurs Corrupted communications is detected using the 16 bit CCITT CRC algorithm computed over transmitted data Packets transmitted and received include the CRC within the packets The parameter sent with the SAF command is the communications time out This time out in seconds is the time between the reception by the pump of consecutive valid communications packets Each time a valid communications packet is received the time out is reset If the time out elapses a pump alarm will occur stopping the pump and the Pumping Program The buzzer will sound if alarms are enabled alerting the user The communications time out timer will not restart until the next reception of a valid packet In addition there is a 0 5 second packet inter byte time out While receiving a communications packet and before its complete reception if a delay of 0 5 seconds occurs between bytes the incomplete packet will be discarded With the Auto Alarm feature whenever a pump alarm occurs such as a pump stall a response packet with the alarm status information will automatically be transmitted Until the Safe Mode is disabled each time power is applied to the pump the pump defaults to the Safe mode of communications but the communications time out timer will not be enabled until the first re
40. erview The model NE 500 NE 501 is a general purpose single syringe pump capable of infusion and withdrawal It is controlled from a microcontroller based system which drives a step motor allowing a large range of pumping rates calibrated to the inside diameter of the loaded syringe The syringe is driven from a drive screw and drive nut mechanism Features Infusion and withdrawal pumping of syringes up to 60 mL 140 mL partially filled RS 232 bi directional control from a computer Built in pump network driver Pump network Pumping rates from 0 73 uL hr with a 1 mL supports up to 100 pumps and other devices inge to 2120 mL hr with a 60 mL syringe end riae SETS Two modes of RS 232 control Basic and Safe NE 501 only Stall detection Automatically Safe mode provides communication error stops pump when pumping is impeded detection loss of communication detection and automatic transmitting of alarm conditions Infusion and withdrawal volumes separately accumulated TTL logic I O with firmware filtered control inputs to eliminated glitch d ringi th Programmable dispense volumes I NEN control inputs pease Biases allowing compl Configurable and programmable TTL pumping applications and interaction with operational trigger for flexible logic control external devices P Failure Mode Restarts the P i Program Sub Programs selectable by the user bo Eb MP SURE ME MES rogram after a power interruption
41. es on the input lines must be within the following ranges TTL logic low 0 0 to 1 5 V logic high 1 3 5t0 5 25 V The Vcc and Ground pins pins 1 and 9 are for logic reference only To assure proper voltage levels the Ground pin should always be connected to the signal ground of a sensing or controlling device that is attached to any other pin on the TTL I O connector The Vcc pin should not be used to source current The TTL I O pins are defined as follows Publication 1200 02 37 09 18 14 New Era Pump Systems Inc www SyringePump cOm Model NE 500 NE 501 Multi Phaser DB 9 Connector TTL I O Pin Definition Type Function 1 Vec SV Reference Logic high reference Power on indicator Configurable start stop operational trigger input Operational Trigger Input FT Foot Switch Falling edge Start or stop trigger Command TRG aa FH Foot Switch Hold Falling edge Start trigger Rising edge Stop trigger F2 Foot Switch Reverse Rising edge Start or stop trigger LE Level Falling edge Stop trigger Rising edge Start trigger ST Start only Falling edge Start trigger T2 Start only Reverse Rising edge Start trigger SP Stop only Falling edge Stop trigger P2 Stop only Reverse Rising edge Stop trigger RL Start on low level Low level Start trigger RH Start on high level High level Start trigger SL Stop on low level Low level _ Stop trigger SH Stop on high leve
42. esee eene e 30 8 5 RS 232 COMMAND SET 5 iiieeoss ssa eno eot avene e ade ene pede Unto s de Sene e Ee eue Pa de gue G pa suene ade on pe PP a UTERE 30 8 5 1 PROGRAM FUNCTION COMMANDS cccccccccccccsssssssssssseccsessssssessseceessesesseesssceceeseees 30 8 5 2 PUMP OPERATIONAL COMMANDS iii eee 33 8 5 3 CONFIGURATION AND SETUP COMMANDSG cccccccccccssssssssssssccecsssssssesssceseesseseeeess 33 BISA alle GENERAL CONTROL AND STATUS COMMANDS 82919 a RR AA Pd GERNE UD cada cde RR ES SYSTEM COMMANDS 8 6 GETTING STARTED WITH RS 232 ee eeee eese ee eene eese eese eee tn nose eee tn esee eene sees eene eee eena 36 9 LOGIC INTERFACE TTL INPUT AND OUTPUT e ee een 37 9 1 TTL I O OPERATIONAL CONTROLSS eee eee e eee eoe eee tne teens eese tenes e eee esee setae eese aa 38 9 2 TTL I O CONTROL FROM THE PUMPING PROGRAM eeeee eee eee en oeste sesto eno seen 40 Publication 1200 02 iii 09 18 14 New Era Pump Systems Inc www SyringePump com Model NE 500 NE 501 Multi Phaser 93 TTL I O CONTROL FROM RS 232 eere reete o sarei ee Pa reor s bas ease Paseos sbas eU roa eina a Gene nd 40 ELE APPENDEX ERR 41 10 1 RS 232 COMMAND SUMMARY cssssscsesssscccesssccccesssccccesssccecesssscccesssscecessssccsessnseoees 41 10 2 RS 232 PUMP NETWORK CONNECTOR WIRING eeeee eee eee eno eese toe e teet esee te tno eees 42 10 3 ACCESSORIES eotee
43. eturn lt STX gt gt 0x02 Start of packet transmission indicator lt ETX gt gt 0x03 End of packet transmission indicator lt CRC 16 gt gt lt byte gt lt byte gt 16 bit CCITT CRC of lt transmitted data gt high byte low byte lt length gt gt lt byte gt Number of bytes remaining in packet including this byte 8 3 5 Network Command Burst The Network Command Burst feature is only applicable when communicating to a network of pumps This special feature allows commands to be sent to a network of pumps simultaneously For example changing the pumping rates simultaneously on a network of pumps Note Since this special feature violates the general communications protocol of one command one response all of the pumps will be responding simultaneously and therefore the communications response to a Network Command Burst will be gibberish and should be ignored Command Format Command Burst gt n command Network Command Burst gt Command Burst gt Network Command Burst Where n indicates the address of the pump that is to execute command Maximum address is 9 n gt 0 9 Example Change the pumping rates of the 3 pumps on a pump network as follows Pump 0 100 mL hr Pump 1 250 mL hr Pump 2 375 mL hr Publication 1200 02 29 09 18 14 New Era Pump Systems Inc www SyringePump com Model NE 500 NE 501 Multi Phaser Assuming that the current pumping rate units of all 3 pumps are
44. functions which guarantees consistent and precise operation of the pump automatically and with or without any user intervention A Pumping Program can be as simple as continuous pumping at a fixed infusion rate Or a Pumping Programs could consist of a pumping rate and direction of pumping for a specified volume then switch to another pumping rate Also a Program can interact with external devices through the TTL I O connector make decisions or stop pumping for a period of time Programs are broken into individual operations called Phases Each Phase consists of a function that can be a control function or pumping function A pumping function such as RATE consists of a pumping rate optional Volume to be Dispensed and the pumping direction Complex dispensing systems can be designed involving multiple liquids each dispensed from a different pump plus other equipment and sensors Pumping Programs can be designed for each pump which enables multiple pumps to synchronize with each other and the other equipment and sensors using a cable connected to the TTL I O connectors of each pump When the Pumping Program is started either from the keypad TTL I O connector or from RS 232 the Pumping Program will begin with Phase 1 of the Program After the completion of each Phase the pump will immediately start the next consecutive Phase This linear sequence of Phases can be altered by certain functions that direct the Pumping Program to con
45. he TTL I O connector or set output levels These are summarized in the following table Pumping TTL I O Control Pin Pin Action Program Function FUN OUT n Program Output 5 FUN EVN nn Event Trigger 4 Low level when executed or a falling edge afterward FUN EVS nn Event Square wave 4 Trigger FUN IF nn Program Input 6 Low level causes a jump to Phase nn FUN PAS 00 Operational Trigger 2 Trigger activation resumes Program operation The Following Program Functions refer to and only work with any of the Expansion Connector TTL pins fee Function FUNPRI Sub ProgramSeleetion 0 FUNPRL Sub Program Start Label FUNOEO Setpnlow 0 y FUNOE Setpinhigg oOo o FUNEPL Pause Pumping gram and wait for edge or level trigger FUNEPE Pause Pumping Program and wait for edge trigger FUNEVE Set event trap FUN PRI FUN PRL FUN OE0 FUN OE1 FUN EPL FUN EPE FUN EVE 9 3 TTL VO Control from RS 232 The logic levels of pins 2 3 4 and 6 plus the 5 Expansion Connector pins can be queried from an attached computer using the RS 232 IN command The output logic level of pin 5 plus the 5 Expansion Connector pins can be set with the RS 232 OUT command The expansion I O connector on the PCB can be queried or set Publication 1200 02 40 09 18 14 www SyringePump com Model NE 500 N
46. hen the low pressure trap is triggered the pump sets the high pressure trap PHASE 07 and begins to increment the flow rate The flow rate is incremented in 1 0 mL hr steps with every 0 25 mL dispensed PHASE 08 10 If the high pressure trap hasn t as yet been triggered the flow rate will max out at 25 0 mL hr while waiting for the high pressure trap PHASE 11 When the high pressure point is reached the pump immediately will drop down to 10 0 mL hr PHASE 02 and once again wait for the low pressure point Phase Function OUT 0 Phase Function Rate Volume Direction RAT 10 0 mL hr 0 005 Infuse Phase Function EVN 05 Phase Function Rate Volume Direction 4 RAT 10 0 mL hr 0 0 mL off Infuse Phase Function OUT 1 Phase Function Rate Volume Direction 16 RAT 10 0 mL hr 0 005 Infuse Phase Function EVN 01 Phase Function ss LPs Phase Function Rate Volume Direction 19 INC 1 0 0 25 mL Infuse Phase Function LOP 14 Phase Function Rate Volume Direction RAT 25 0 mL hr 0 0 mL off Infuse 7 4 6 Example 6 Automated Dispensing with Synchronization E Restart Pumping Program P Power Failure Mode Pumping Program Restart at Power Up 5 00 00 5 00 00 5 00 00 5 00 00 5 00 00 Refill Even
47. ial number located on the side of the pump and the date of purchase New Era Pump Systems Inc located in Farmingdale NY USA can be contacted at Phone 631 249 1392 FAX 707 248 2089 Email INFO SYRINGEPUMP COM WWW SYRINGEPUMP COM This Operating Manual and the NE 500 NE 501 s hardware electronics and firmware are copyrighted Copyright 2004 2014 all rights reserved 1 1 Warnings and Cautions D Read the user s manual No user serviceable parts are inside Disconnect power from the pump when connecting or disconnecting cables Do not immerse the pump in liquid Install on a stable surface Keep hands and loose clothing away from the pumps moving parts The pump can automatically start when the Pumping Program is operating or when attached to an external control device Prevent liquids from entering openings of the pump Do not push objects of any kind into the chassis openings except for appropriate cables and connectors If the pump becomes damaged do not use unless certified safe by a qualified technician Damage includes but is not excluded to frayed cords and deterioration in performance Discharge static from control cables before connecting by touching the cable to ground Before touching the pump discharge static by touching ground 1 2 Disclaimer New Era Pump Systems Inc makes no representations or warranties expressed statutory or implied regarding the fitness or merchantability of this product fo
48. in normal execution it will be interpreted as Jump to Phase 1 JP 01 ending the sub program and assuming Phase 1 is a Sub Program Select function Pr In the user will be immediately prompted to select a sub program 7 3 9 Define Starting Phase of Loop Command FUN LPS Defines the start of a Program loop For a full description of Program looping see sec 7 3 11 Define Loop End and Loop Repetitions 7 3 10 Define Continuous Loop End Command FUN LPE Loops to the most recently executed unpaired loop start Phase or Phase 1 if none This function allows a section of the Program to be repeated continuously For a full description of Program looping see sec 7 3 11 Define Loop End and Loop Repetitions 7 3 11 Define Loop End and Loop Repetitions Command FUN LOP nn Repeats execution of the defined loop nn times Loop starts and loop ends are uniquely paired during looping When an unpaired loop end function is executed it is paired with the most recent unpaired loop start function executed FUN LPS If no unpaired loop start function exists Phase 1 is used as an implied unpaired loop start This pairing defines the loop and the range of Phase numbers between the paired loop functions defines the scope of the loop When a loop end function is executed Program operation continues with the loop start function paired with the loop end function There are 2 loop end function
49. infusion system Alternatively the pumps can be set to Dual Pump Mode whereby the second pump will always follow the program on the first pump including starting stopping direction changes and rate changes When either pump stops for any reason the other pump stops 10 3 5 Valve Controller Part ADPT VALVE INTERFACE 1 For one pump Part ADPT VALVE INTERFACE 2 For two pumps includes CBL TTL 1 Provides a control interface for your electronic valves Attach your electronic valves and the interface will control the activation of the valves The 2 pump interface is used to create a continuous infusion refill system 10 3 6 Foot Switch Part ADPT 2 Allows the pump to be operated from a foot switch Attaches to the TTL I O connector 10 3 7 Firmware Upgrade Part FW 1 NE500 Upgrades to the newest version of the firmware Part FW 1X NE500 Gradient Linear ramping for smooth gradients plus other new program functions Part FW 1X2 NE500 Also expands the Pumping Program memory to 340 Phases Contact your dealer for this upgrade and to determine the current available version of the pumps internal firmware 10 4 Troubleshooting and Maintenance Maintenance Periodically apply a small amount of all purpose oil to the guide rods and grease to the drive screw The mechanism should be kept clean to prevent impeded operation No other special maintenance or calibrations are needed RS 232 Communications If no RS 232 communication
50. ing data frame Supported RS 232 Data Frames Baud rate 19200 Frame 10 bit data frame 8N1 Start bit 1 Data bits 8 Stop bits 1 Parity None Every command received by a pump in the network is acknowledged by the pump with a response packet that includes a status character indicating the current operational state of the pump Two packet protocols are supported Basic and Safe The enabled communications protocol is stored in non volatile memory and therefore will be in effect at power up Safe Mode provides a safer communications protocol than Basic Mode Safe Mode detects corrupted data and loss of communication as well as automatically transmitting status packets when an alarm occurs Considering that the 19200 baud rate communicates at 52 us per bit a small glitch on the RS 232 cable flipping a single bit can convert a transmitted infusion rate of 100 mL hr into 900 mL hr the need for the Safe Mode in a production environment is evident However Basic Mode is excellent for simplifying early development of a control program While in the Basic Mode the pump will accept either communications protocol Basic or Safe Though the response packet will be in the current communications mode This allows a computer s communication s driver to be designed with just one mode A Safe Mode communications driver can send a SAF command to the pump in the Safe Mode protocol while the pump is in Basic Mode The response to the SAF
51. inge holder above the syringe holder block Turn it 1 4 turn and then lower it onto the syringe holder block The syringe holder should be out of the V slot 4 Load the syringe with the barrel over the syringe holder and the syringe plunger towards the middle of the pump Place the barrel on the syringe holder in the V slot with the barrel flange inserted between the syringe holder block and syringe retainer bracket 5 On the pusher block turn the thumbscrew to make the slot large enough for the plunger flange Press in fully the white drive nut button on the pusher block releasing the pusher block Then slide the block towards the syringe plunger Place the syringe plunger flange into the slot and against the anti siphon plate When the flange is positioned in the slot release the white drive nut button 6 Lift the syringe holder to slightly above the height of the syringe barrel and turn the syringe holder 1 4 turn back to its original position and then lower it onto the syringe barrel 7 Firmly push in the syringe retainer bracket against the syringe barrel flange and tighten the 2 thumbscrews on the syringe retainer bracket On the pusher block turn the thumbscrew to tighten the plate against the plunger flange To unload the syringe reverse the instructions for syringe loading 5 Operation Before the pump can be operated the pumping data must be setup At minimum the syringe inside diameter and a non zero pumping
52. input pin has no effect When the mode is set to dual pumps DIN 1 then if the current pumping direction is withdraw a rising edge sets the direction to infuse If the current pumping direction is infuse a falling edge sets the direction to withdraw Otherwise this input pin has no effect Dual and reciprocating pumping systems are created using 2 pumps attached with the accessory cable CBL TTL 1 The output pin provides an output signal to external devices indicating the direction of pumping A logic low indicates withdraw and a logic high indicates infuse For example this pin can be used to control an external valve allowing the syringe to refill from a reservoir Sub Program Selector Switch Interface For use with FUN PRI and FUN PRL Pumping Program functions Attach a Hex output selector switch to Expansion Connector Pins 1 to 5 as needed with Pin 1 as LSB Pins 1 to 5 LSB to MSB are interpreted as a 5 bit inverted hex number when the sub program is selected Open connections are read as 0 s while closed connections shorted to ground are read as 1 s With nothing connected sub program 0 will be selected With Pins 1 to 5 shorted to ground sub program 31 will be selected Publication 1200 02 39 09 18 14 New Era Pump Systems Inc www SyringePump com Model NE 500 NE 501 Multi Phaser 9 2 TTL I O Control from the Pumping Program Various Pumping Program functions can define how the pump reacts to levels on t
53. ispensed Infuse 5 0 mL at 500 mL hr and then infuse 25 0 mL at 2 5 mL hr Then stop the pump Volume 5 0 mL Volume 25 0 mL Function Rate 1 RAT 500 mL hr Function Rate Phase _ a Phase RAT 2 5 mL hr Phase _ 3 Function 3 STP To send this program to the pump send the following sequence of commands PHN 1 FUN RAT RAT 500 MH VOL 5 0 DIR INF PHN2 FUN RAT RAT 2 5 MH VOL 25 0 DIR INF PHN3 FUN STP 7 4 2 Example 2 Repeated Dispenses with Suck Back ml hr Rate Dispense 2 0 mL with a 5 minute pause between dispenses In addition after each dispense a volume of 0 25 mL is sucked back to prevent dripping Also 30 seconds before the end of the pause interval a beep is sounded to alert the operator to prepare for the next dispense Starting with the second dispense 0 25 is added to the volume dispensed to compensate for the sucked back volume of the previous dispense By changing the last Phase to a FUN LOP nn function the total number of dispenses can be set Publication 1200 02 18 09 18 14 New Era Pump Systems Inc www SyringePump com Model NE 500 NE 501 Multi Phaser When entering a function with associated data such as with the Pause in Phase 5 or the Loop in Phase 6 the function is entered in 2 steps First select the function and store it Then enter the associated data Phase Function Rate Volume RAT
54. ith Phase 1 A different starting Phase can be specified with the RUN command If the current Program Phase specifies a pumping rate the pump will begin pumping The pumping direction will also depend on the Program Phase setup The volume dispensed can be queried with the DIS command While pumping the pump will pump continuously in the current Program Phase unless a Volume to be Dispensed is set or an Event trigger is set If a Volume to be Dispensed is set the Program Phase will be complete after the set volume has been infused or withdrawn measured from the start of the Phase Publication 1200 02 6 09 18 14 New Era Pump Systems Inc www SyringePump com Model NE 500 NE 501 Multi Phaser 5 4 Pumping Rate Command RAT lt float gt lt units gt Sets queries the pumping rate and rate units 5 4 1 Changing the Pumping Rate and Direction While Pumping Command RAT lt float gt Except with some complex Pumping Programs the pumping rate can be changed while the pump is operating To change the pumping rate while pumping use the RAT command to send a new rate A new rate set while pumping will not be stored in non volatile memory Rate units cannot be changed while pumping If the new rate is valid it will take effect immediately The pumping direction can be changed while pumping if the Volume to be Dispensed is 0 0 The direction command DIR will immediately change the pumping direction and
55. l High level Stop trigger ET Program function redirect trigger to Event trap BT Program function Redirects Stop key to Event trap 3 Pumping Direction Input Changes pumping direction according to setup Command DINO DIN 1 Falling edge Infuse Withdraw Rising edge Withdraw Infuse 4 Event Trigger Input Event input or user definable input 5 Program Output Output Program controlled output or user definable output 6 Program Input Input Program conditional input read by the IF program function Also user definable input Also used by the keypad lockout function 7 Pump Motor Operating Output Setup Command ROM 0 High Pumping Low Not pumping Setup Command ROM 1 High Pumping or Pause timer Low Not pumping 8 Pumping Direction Output High Infuse Low Withdraw 9 Ground OV Reference Logic low reference 9 1 TTL I O Operational Controls Operational Trigger Pin 2 The input signal on this pin controls the operation of the Pumping Program Its functionality is user configurable Use the TRG command to configure the default settings for this input pin See Section 6 5 TTL I O Operational Trigger Default Configuration Each option defines when the Operational Trigger input is activated When activated the trigger emulates a Start Stop key Foot Switch Operates like a Start Stop key whereby each falling edge contact to ground either starts or stops pauses the Pumping Program Foot Switch Hold Falling edge sta
56. m phase to be set Now all pumping data will refer to next currently selected Phase Data for the current Phase can now be entered Continue selecting Phase numbers and entering the infusion or control setup for each Phase of the Pumping Program The entire Pumping Program will be stored in non volatile memory Use the STOP function FUN STP to stop the pump and end the Pumping Program If the Pumping Program does not operate the pump continuously the last Phase of the Pumping Program must be a STOP function unless the last Phase number is the maximum Phase number When the Pumping Program is started with the Operational Trigger TTL I O input or RS 232 RUN command the Pumping Program will begin operating from Phase 1 Very complex dispensing Programs can be created with the Program functions available Section 7 3 contains a detailed description of all the functions 7 2 Clearing the Pumping Program It is not necessary to clear out a previous Pumping Program before entering a new program New commands will overwrite previous ones and unused Program Phases will just be ignored To clear out the pumping program memory and reset communication parameters send the command RESET 7 3 Program Function Descriptions gt Each program function must be in a separate Program Phase 7 3 1 Rate Function Command FUN RAT This is the most basic function to simply command the pump to dispense at a specific rate Defines a
57. mands work in addition to allowing you to quickly develop the control sequence that will eventually be coded into the software being developed The final benefit of using a terminal emulator is the elimination of several variables if the control software does not work properly If the pump works correctly with the terminal emulator then this verifies that the hardware is working properly and will work with any software Any communications problems can then be narrowed down to the control software Publication 1200 02 36 09 18 14 New Era Pump Systems Inc www SyringePump cOm Model NE 500 NE 501 Multi Phaser Note on USB If an RS 232 port is not available on your PC the pump may be operated through a USB to RS 232 converter cable available as an accessory part CBL USB232 This cable attaches to the standard RS 232 to PC cable part CBL PC PUMP 7 The PC will create a virtual RS 232 communications port that communicates through the USB to RS 232 converter cable The terminal emulator can communicate through this virtual port 9 Logic Interface TTL Input and Output Resistor pads or solder 2 pads if none Suggested resistor value is 200 Q Pin 1 ODE LN Of Motor pP ey Connector E Expansion Connector Pin Out EJ e Expansion Ground Ground Ea o e Connector See pin 1 LSB Ground mie Pin Out Pin 2 Ground Q a x Pin 3 Ground Pin 5 Pin 4 Ground Pin 5 MSB Ground
58. mping Rate Function Function Parameter Start Trigger 3 Setup www SyringePump com Model NE 500 NE 501 Multi Phaser The sequence of automated operations entered into the pump This could be as simple as a single function to pump at a single infusion rate continuously When the pump is started with the RUN command or any other source the pump begins performing the operations in the Pumping Program until the Pumping Program either stops automatically or the pumped is stopped with the STP command or from any other source While performing the operations defined in the Pumping Program the Pumping Program is referred to as operating While Operating the motor can be pumping or stopped according to the Pumping Program The motor is stopped and the pump is not operating the Pumping Program The Pumping Program has been stopped but can be resumed at the point where it was stopped Continuing a Pumping Program that was Paused before the completion of the Pumping Program The Pumping Program continues at the point where the Pumping Program was stopped The pump has performed a single operational Phase as defined in the Pumping Program A single defined operation in the Pumping Program A Program Phase s numerical sequence location in the Pumping Program Each Pumping Program Phase instructs the pump to perform a particular operation Only one Program Phase is selected at any one time This is the current Phase Each
59. nds New settings for any of the following commands will be stored in the non volatile memory LOW MOTOR NOISE LN lt on off gt Set query low motor noise mode Increases motor stepping resolution Publication 1200 02 33 09 18 14 New Era Pump Systems Inc www SyringePump cOm Model NE 500 NE 501 Multi Phaser ALARM SETUP AL lt on off gt Set query alarm setup mode Set alarm enables or disables alarm buzzer mode POWER FAIL SETUP PF lt on off gt Set query Power Failure mode Set Power Failure enables or disables Power Failure mode TTL I O OPERATIONAL TRIGGER DEFAULT SETUP TRG trigger setup Set Query TTL I O Operational Trigger default input configuration TTL I O Operational Trigger is set to trigger setup trigger setup gt FT Foot switch trigger falling edge FH Foot switch hold falling edge start rising edge start F2 Foot switch reverse rising edge start stop LE Level trigger rising edge start falling edge stop ST Start only trigger falling edge start T2 Start only trigger reversed rising edge start SP Stop only trigger falling edge stop P2 Stop only trigger reversed rising edge stop RL Start on low level RH Start on high level SL Stop on low level SH Stop on high level OF Trigger off disabled TTL I O DIRECTIONAL CONTROL INPUT SETUP DIN 011 Set query directional control input setup Settings gt 0 Falling edge Infu
60. nsion Connector A rotary selector switch can be attached to the Expansion Connector to create a stand alone user interface See Sec 9 Logic Interface TTL Input and Output for more information about the Expansion connector and attaching a switch Auto Run Production Mode When Phase 1 is set to Sub Program Selection Input and Lockout Mode is selected the pump will enter Auto Run Mode When the pump is powered on it will immediately begin executing the Pumping Program When a start trigger such as from a foot switch the Pumping Program will read the selected Sub Program number from the Expansion Connector and begin executing the Sub Program This permits a set of production dispenses to be programmed into the pump The user then would only be able to select from one of these production dispenses and not make any changes Foot Switch Trigger Feature If the Pumping Program was Paused and the Paused Phase was a continuous pumping Rate function then starting the pump from the Operational Trigger pin 2 such as with a foot switch will cancel the Pause and restart the Pumping Program from Phase 1 causing the current program selection to be re executed When the Sub Program Selection Input function is executed the Pumping Program pauses and waits for a start Publication 1200 02 13 09 18 14 New Era Pump Systems Inc www SyringePump com Model NE 500 NE 501 Multi Phaser trigger When a start trigger is received the Sub P
61. ogram Phase Use the Phase select command PHN to query or select the current Phase A Phase consists of the pumping rate Volume to be Dispensed and the pumping direction A packet without a command is interpreted as a status query The addressed pump responds with a status only response packet Except where noted a command without any parameters is a query command The response packet data will include the requested data In general the query response data will be in the same format as the parameters for setting the command For example the query diameter command DIA will respond with lt float gt as the response lt data gt Otherwise the command is a set command If the data was set a status only response packet will be sent If the data was not set the response packet will include an error command error message indicating why the data was not set All commands are upper case but in Basic Mode will be accepted as lower case plus spaces and control characters will be ignored This facilitates manually entering commands using a terminal emulator command gt DIAMETER DIA float Set query inside diameter of syringe Set is only valid when the Pumping Program is not operating Setting the syringe diameter also sets the units for Volume to be Dispensed and Volume Dispensed if not overridden with the VOL command 8 5 1 Program Function Commands The following commands a
62. on operates 6 7 Pump Motor Operating TTL Output Configuration Command ROM lt n gt Configures the functionality of the Pump Motor Operating TTL output pin TTL pin 7 Sets the output to logic high only when the motor is operating pumping Sets the output to logic low when the motor is not operating or when the Pumping Program is executing a pause timer or is stopped Sets the output to logic high when the motor is operating pumping or when the Pumping Program is executing a pause timer Also alters operation of Alternating Communications Mode Sets the output to logic low when the Pumping Program is stopped 6 8 Lockout Mode Command LOC lt n gt n Setting 0 Disabled 1 Enabled Lockout mode is useful for implementing Sub Programs in a production setup Auto Run Mode When used in conjuction with the Sub Program Select programming function FUN PRI as Phase 1 the pump will enter Auto Run Mode In this mode on power up the Pumping Program will immediately begin to execute and upon receiving an Operation Trigger input the Pumping Program will immediately begin executing the Sub Program selected with the Expansion Port 6 9 Notification Beep Mode Command BP lt n gt n Setting 0 Disabled 1 Enabled Sets a continuous beeping at the end of the Pumping Program or waiting for a trigger input 7 Pumping Program A Pumping Program is simply a pre defined sequence of actions or
63. ondary pump requires the accessory cable CBL DUAL 3 In Reciprocating or Dual Pumps Modes the secondary pump must be left in its default communications setting of Address Mode Address 0 and 19 200 baud rate See the documentation with CBL DUAL 3 cable for more detailed information 6 2 Power Failure Mode Command PF n n Setting 0 Disabled 1 Enabled When enabled if the Pumping Program was operating when power to the pump was disrupted the Pumping Program will automatically start operating when power is reconnected to the pump E CAUTION The Pumping Program will start operating from the beginning of the Pumping Program Phase 1 regardless of what part of the Pumping Program was operating when the power was disrupted When the NE 500 501 syringe pump is used as a component in an automated infusion withdrawal dispensing system a Pumping Program can be designed to automatically synchronize the pusher block at the start of the Pumping Program This would be accomplished using attached sensors that send signals to the Pumping Program 6 3 Low Noise Mode Command LN lt n gt n Setting 0 Disabled 1 Enabled A side effect of the NE 1000 s high precision micro stepped motor driver is a high frequency resonance sound at very low pumping speeds This mode minimizes this sound by reducing the micro stepping increasing pulsations 6 4 Audible Alarm Enable Command AL lt n gt l
64. ong with other pumps from the NE 1000 series of pumps to one communications port on a computer See section 9 Logic Interface TTL Input and Output for a diagram of the pump s connectors When communicating with a pump in a multi pump network each preceding pump in the network must be powered on Note on USB If an RS 232 port is not available on your PC the pump may be operated through a USB to RS 232 converter cable available as an accessory part CBL USB232 This cable attaches to the standard RS 232 to PC cable part CBL PC PUMP 7 The PC will create a virtual RS 232 communications port that communicates through the USB to RS 232 converter cable The terminal emulator can communicate through this virtual port Each pump in the network needs a unique network address to identify the pump to the computer Network addresses are from 00 to 99 If the network consists of only 1 pump set the pump s address to 0 the factory default address Also each pump needs to be set to the same baud rate as the computer The default baud rate is 19 200 8 2 RS 232 Pump Network Configuration If only one pump is being used leave the address at the default of 0 Up to 100 pumps from the NE 1000 series of pumps can be attached to a computer in a single pump network The network address is set using the command ADR nn where nn is the pump s network address from 0 to 99 If only one pump is in the network leave the address at the default address
65. ow level on the Event Trigger input pin at the time when the function is executed When triggered the current operation of the pump and the Pumping Program is interrupted and the Pumping Program immediately continues operation jumps to with Phase number nn After being triggered the event trigger is reset If an event trigger function is executed while another event trap is still set the new event trigger will replace the previous event trap 7 3 15 Setup Event Square Wave Trigger Jump Phase Command FUN EVS nn The Event Square Wave function operates the same as the EVN Event function with the exception of the triggering conditions This function will trigger on either the rising or the falling edge of the TTL Event Trigger input pin 4 Therefore a square wave function on the inupt pin can be used to toggle the pump between 2 sections of a Pumping Program An example of this would be a Pumping Program that switched between a slow and fast pumping rate controlled by a square wave input Publication 1200 02 15 09 18 14 New Era Pump Systems Inc www SyringePump com Model NE 500 NE 501 Multi Phaser 7 3 16 Setup Expansion Port Event Trigger Jump Phase Command FUN EVE expansion pin gt The Event function sets a background event trap that is triggered by an external signal on a specific Expansion Port connector pin See sec 9 Logic Interface TTL Input and Output for detailed information about
66. ptions A None Syntax expands to nothing lambda production Nem Description of syntax expansion 8 3 2 RS 232 Protocol Basic Mode Command syntax to pump basic command protocol command data CR Response syntax from pump basic response protocol gt STX response data lt ETX gt In the Basic communications mode a master slave protocol is used whereby the pump will only transmit in response to a received command When the pump receives the basic command protocol command data will automatically be stripped of all space and control characters and all text will be converted to upper case This simplifies communications with the pump when commands are being manually typed in from a generic terminal emulator To return the pump to Basic mode when in the Safe mode send the following packet to the pump 0x2 0x8 SAFO 0x55 0x43 0x3 8 3 3 RS 232 Protocol Safe Mode Command syntax to pump safe command protocol gt STX length command data lt CRC 16 lt ETX gt Response syntax from pump safe response protocol gt STX length response data CRC 16 ETX Safe mode uses a more structured protocol including detection of corrupted communications communications time outs and auto alarm responses Safe mode is enabled using the SAF command whose parameter setting is stored in the non volatile memory Safe mode uses a modified mast
67. pumping function with a fixed pumping rate This function defines a pumping setup consisting of the pumping rate optional Volume to be Dispensed and pumping direction Use the RAT VOL and DIR commands to set or review the Rate Function s setup For continuous pumping set the Volume to be Dispensed to 0 0 7 3 2 FILL Fill Function Command FUN FIL The Fill function reverses the pumping direction and withdraws or dispenses the volume dispensed or withdrawn After a series of arbitrary dispenses the Fill Function uses the Volume Dispensed to automatcally refill the syringe The Volume Dispensed is cleared when the Fill Function begins The pumping rate can be set as with the Rate Function Publication 1200 02 12 09 18 14 New Era Pump Systems Inc www SyringePump cOm Model NE 500 NE 501 Multi Phaser Fill at the current dispense withdraw rate If the Fill function s pumpng rate is set to 0 0 the previous function s pumping rate will be used for the Fill rate 7 3 3 Increment Rate Function Command FUN INC The increment and decrement functions operate the same as the RATE function except that the specified rate is added INC or subtracted DEC from the current pumping rate The current pumping rate when the function is executed is the base pumping rate for the function If no base pumping rate exists such as when executing a pause function or when the Pumping Program i
68. r any particular purpose Further New Era Pump Systems Inc is not liable for any damages including but not limited to lost profits lost savings or other incidental or consequential damages arising from ownership or use of this product or for any delay in the performance of its obligations under the warranty due to causes beyond its control New Era Pump Systems Inc also reserves the right to make any improvements or modifications to the product described in this manual at any time without notice of these changes New Era Pump Systems Inc products are not designed intended or authorized for use in applications or as system components intended to support or sustain human life as a clinical medical device for humans or for any application in which the failure of the product could create a situation where personal injury or death may occur All brand and product names used in this manual are the trademarks of their respective owners 1 3 Warranty New Era Pump Systems Inc warranties this product and accessories for a period of two years parts and labor from the date of purchase The repaired unit will be covered for the period of the remainder of the original warranty or 90 days whichever is greater Return shipping charges are not included A return authorization number must be obtained from New Era Pump Systems Inc before returning a unit for repair Warranty covered repairs will not be performed without a return authorization number A
69. re relevant to the currently select Program Phase Note During a Pumping Program s operation the currently selected Phase can change automatically PHASE NUMBER PHN phase data Set query currently selected Program Phase Publication 1200 02 30 09 18 14 New Era Pump Systems Inc www SyringePump com Model NE 500 NE 501 Multi Phaser Set Currently selected Phase is set to phase data Previous Phase is stored in non volatile memory and the requested Phase is recalled from the non volatile memory Set is only valid if the Pumping Program is not operating Query response phase data PUMPING PROGRAM FUNCTION FUN phase function Currently selected Phase Set query the Pumping Program Phase s function This command is relevant to the currently selected Phase Set is only valid if the Pumping Program is not operating For a more detailed description of Program commands see sec 7 3 Program Function Descriptions phase function gt Rate Data Functions When a Phase s function is set to a Rate Data Function use the RAT VOL and DIR commands to setup the pumping parameters for the current phase RAT FIL INC DEC STP PAS number data PAS n n LOP count data LPS LPE JMP phase data TRG nn IF phase data EVN phase data EVS phase data EPL expansion pin EPE expansion pin EVE expansion pin EVR CLD OU
70. rigger default setting Sound short beep RAT CII float UM MM I UH MH Pumping rate VOL float volume units gt Volume to be Dispensed or set Volume units DIR INFI WDRIREVISTK Pumping direction RUN phase data Starts the Pumping Program E phase data Pumping Program event trigger PUR Start purge STP Stop pauses the Pumping Program DIS Query volume dispensed CLD INFI WDR SAF lt n gt lt n gt lt n gt Clear volume dispensed Safe communications mode LN 011 Low motor noise mode AL 011 Alarm buzzer mode PF 011 Power failure auto restart mode TRG FTIFHIF21 LE I ST T2 SP P2 I RLIRHISLISHIOF Operational trigger default mode DIN 011 Directional input control mode ROM 01 1 Pump Motor Operating TTL output mode LOC P 011 Keypad lockout mode or Program Entry Mode lockout BP 011 Key and Notification beep mode OUT E expansion pin 15 011 Set TTL output level IN E lt expansion pin212131416 Query TTL input level BUZ 0l 1 n Buzzer control VER Query firmware version System Commands Valid regardless of current network address ADR n n B lt baud rate gt Network address and baud rate Publication 1200 02 41 09 18 14 New Era Pump Systems Inc www SyringePump com Model NE 500 NE 501 Multi Phaser ADR DUAL RECP ALTR Set Reciprocating Dual or Alternating pumping mode RESET Resets pump Clears program memor
71. rogram number is read from the Expansion Connector and the selected Sub Program begins execution Also the accumulated infusion and withdrawal dispensed volumes are set to zero The pump searches for the selected Pumping Program Selection Label starting with the current Phase and continuing to the end of the Pumping Program memory then from Phase 1 until the current Phase is reached again If the selected Sub Program Start Label is not found the OOR out of range error message is send in response to the current or next command If more than one Phase is defined with the same Sub Program Start Label then execution continues with the first matching label encountered More than one Program Selection Input function can be defined and placed at any Program Phase needed If alarms are enabled the buzzer will beep continuously while waiting for the start trigger 7 3 8 Sub Program Start Label Command FUN PRL nn The Sub Program Start Label function defines the start of a Pumping Program sub program that can be selected with a switch attached to the Expansion Connector After selecting the function change 00 if needed to a unique Program Label from 0 to 99 See sec 7 3 7 Sub Program Selection Input for a full description Place a Sub Program Start Label with a unique number for each Sub Program from 0 to 99 at the starting Phase of each sub program section When the Pumping Program encounters a Sub Program Start Label
72. rts the Pumping Program and the rising edge stops the Pumping Program With a foot switch the Pumping Program will run while the foot switch was held down Publication 1200 02 38 09 18 14 New Era Pump Systems Inc www SyringePump com Model NE 500 NE 501 Multi Phaser Foot Switch Reversed Operates like the Start Stop key whereby each rising edge either starts or stops pauses the Pumping Program Level Control Falling edge stops pauses the Pumping Program Rising edge starts the Pumping Program This configuration can be used with a contact closure timer or in an automation setup allowing logic level control over the operation of the pump Start Only Falling edge starts the Pumping Program This configuration only allows the starting of the Pumping Program This would be useful for example with a laboratory animal trained to press a lever The animal can start the Pumping Program but repeated presses would have no effect until the Pumping Program permits it Start Only Reversed Same as Start Only but operates on the Rising edge to start the Pumping Program Stop Only Falling edge Stops the Pumping Program This configuration only allows the stopping pausing of the Pumping Program This would be useful for example with an end of travel limit switch Also this switch can be used as a power on homing switch Stop Only Reversed Same as Stop Only but operates on the Rising edge to stop the Pumping Program R
73. s Loop continuous FUN LPE and Loop for a preset number of iterations FUN LOP nn indicated by nn Each time a paired loop end function is executed an iteration of the loop is complete With the FUN LOP nn function after nn number of loop iterations the defined loop is complete and Program execution continues with the next Program Phase after the loop end function The loop is then no longer defined or paired Publication 1200 02 14 09 18 14 New Era Pump Systems Inc www SyringePump com Model NE 500 NE 501 Multi Phaser While executing Phases within the scope of a defined loop another loop start and loop end can be paired and become a defined loop within the scope of the first loop which is referred to as the outer loop The new loop being referred to as the inner loop The pairing of a loop within a paired loop is referred to as nesting of loops with each loop being one nested layer for the duration of the loops pairing Loops can be nested for a total of 3 layers deep Loops can only be nested within the scope of an outer loop 7 3 12 Pause Pumping Command FUN PAS nn n n If nn is non zero the Pumping Program will pause pumping stops pumping for nn seconds After the pause interval the next Program Phase will be executed nn can range from 00 to 99 or 0 1 to 9 9 seconds For pauses longer than the 99 second maximum pause for this function
74. s first started a Program error will occur and the Program will stop The pumping rate units will be the same as the base pumping rate and therefore cannot be set or queried with the pumping rate increment or decrement value As with the RATE function a Volume to be Dispensed and pumping direction can be specified for the increment and decrement functions When used within a Program loop the pumping rate can be incremented or decremented in small step intervals 7 3 4 Decrement Rate Function Command FUN DEC The decrement function subtracts the specified rate from the current pumping rate For a full description see section 7 3 3 Increment Rate Function 7 3 5 Stop Pumping Operation and End the Program Command FUN STP Stops the pumping operation and stops the Pumping Program The Pumping Program will begin at Phase 1 when started again An implicit Stop function is executed when the Program exceeds the maximum Phase number during operation If alarms are enabled the buzzer will beep continuously when the Pumping Program stops 7 3 6 Jump to Phase Command FUN JMP nn The Jump function alters the consecutive operation of Program Phases When executed the Pumping Program will continue operation with Phase nn 7 3 7 Sub Program Selection Input Command FUN PRI The Pumping Program can be broken into sections which can be selected by the user Sub Programs are selected using the Expa
75. s is possible or garbled responses are received from the pump check the following Verify the correct communications port and that the cable is attached to the Computer connection on the pump If the Basic communications mode is used check if the pump is in Safe communications mode See section 8 3 RS 232 Protocol for instructions on how to change the communications mode Verify the pump s network address Publication 1200 02 43 09 18 14 www SyringePump com Model NE 500 NE 501 Multi Phaser New Era Pump Systems Inc Pusher block makes a snap or click sound when the pump is started This is a normal condition When the pusher block is manually moved the drive nut may not have been fully engaged on the drive screw The sound heard is the drive nut engaging on the drive screw Pump doesn t stop after dispensing a set volume The pump was previously setup with a multiple Phase Pumping Program To simply dispense a fixed volume at a fixed pumping rate the second Program Phase must be the Stop function See section 7 1 How to Enter Pumping Programs for instructions on changing the Pumping Program Pump stops pumping after a period of time A dispense target volume has been set Verify that the dispense target volume is set to 0 10 5 Specifications 10 5 1 Mechanical amp Electrical Syringe sizes Number of syringes Motor type Motor steps per revolution Microstepping Advance per step Motor to drive
76. se Rising edge Withdraw Use this setting with the CBL TTL 1 reciprocating pump cable to create a 2 pump continuous infusion system 1 Falling edge Withdraw Rising edge Infuse Use this setting with the CBL TTL 1 reciprocating pump cable to create a 2 pump dual pumping system PUMP MOTOR OPERATING TTL OUTPUT CONFIGURATION ROM lt on off gt Set query Pump Motor Operating TTL output configuration TTL pin 7 Settings gt 0 Output is logic high only when the pump motor is operating pumping 1 Output is logic high when the pump motor is operating pumping or when the Pumping Program is executing a pause timer SET LOCKOUT MODE LOC P lt on off gt Set query lockout mode Lockout mode sets Auto Run mode when used with Sub Programs See sec 13 Sub Program Selection Input for more information Notification Beep Mode BP lt on off gt Set query notification beep After the Pumping Program stops a continuous beeping will sound Publication 1200 02 34 09 18 14 New Era Pump Systems Inc www SyringePump com Model NE 500 NE 501 Multi Phaser 8 5 4 General Control and Status Commands TTL I O OUTPUT SETTING OUT n TTL level E 112131415 TTL level Expansion Port Connector Sets TTL level on user definable output pin on the TTL I O connector n Indicates pin number on TTL I O connector Valid value 5 Program Output pin E Sets pin on Expansion Port I O connector on
77. ssc eese cene osos sae eee eae ure eT Ego espe NA 42 LOSS VAINLASBOXM eo a ear 42 10 3 2 SYRINGE HEATERS 5 tet e ate RE P EHE P DG ERE Oia a EDEN P PG PATE 42 10 3 3 RS 232 NETWORK CABLES ie 42 10 3 4 s AUTOMATION CABLE SPECIAL COMMUNICATIONS MODES CONTROL CABLE 1059 Mx va di ME ER A M as VALVE CONTROLLER 10 326 FOOT SWITCH una duc e tem iet tatem iie 43 10 3 7 FIRMWARE UPGRADE ire 43 10 4 TROUBLESHOOTING AND MAINTENANCE sssvversrscrresss serene sessensesesseneseseseenessosensssese 43 10 5 SPECIFICATIONS 7 iecore ceo oe ene to eene ene to Te ee A I aN 44 10 5 1 MECHANICAL amp ELECTRICAL eee 44 LOIS 2 OPERATIONAL gt La ille e eee trece eo eee eee n e een Ue od 44 10 6 CUSTOM APPLICATIONS eo oo essor e aav ea ra de Un to re e VEU PS TN eR SVP EVE PARU UN EO SENE REU AR ENTRE 44 10 7 SYRINGE DIAMETERS AND RATE LIMITS eere eee ee eee nee en nee e teneo teet tn ee eee eno e eSe 45 Publication 1200 02 iv 09 18 14 New Era Pump Systems Inc www SyringePump cOm Model NE 500 NE 501 Multi Phaser 1 General Information Thank you for purchasing the NE 500 NE 501 OEM Programmable Syringe Pump With the NE 500 NE 501 syringe pump you will be able to perform simple infusions or implement a complex automated dispensing system Please familiarize yourself with the NE 500 501 s operation by reading this user s manual For future reference record the ser
78. store the pumping direction in the current Program Phase Also changing the pumping direction changes the accumulated Volume Dispensed according to the new pumping direction 5 5 Pumping Direction Command DIR INF WDR REV I STK Sets queries the direction of pumping to Infuse INF or Withdraw WDR REV reverses the pumping direction Infuse to Withdraw or Withdraw to Infuse 5 5 1 Sticky Direction STK Valid only when the Pumping Program is stopped Sets the pumping direction of the current Pumping Program Phase to Sticky Direction Sticky Direction will continue the pumping direction of the previous Pumping Phase or if the first Phase set the pumping direction according to the logic level of the Pumping Direction TTL input pin pin 3 Direction Control Reciprocating Pumps Dual Pumps Low Level Infuse Withdraw High Level Withdraw Infuse 5 6 Dispense Volume Target and Continuous Pumping Command VOL lt float gt The VOL command sets queries the Volume to be Dispensed The default volume units are set according to the syringe diameter to either uL or mL The current Pumping Phase will continue to pump infusing or withdrawing until the set Volume to be Dispensed has been pumped For continuous pumping set the volume target to 0 Command VOL 0 5 6 1 Set Volume Units Command VOL ULIML Changes queries the global volume units for dispensing and volume targets to either
79. sub programs The pump cannot be started if an alarm condition exists E phase data Trigger a Pumping Program Event while the Pumping Program is active Triggers a pre defined event defined with the Pumping Program s Event function causing an immediate jump to the Pumping Program Phase defined by the event function If phase data is specified the program will immediately jump to the Pumping Program Phase specified by phase data and cancel any other event set by the Pumping Program PURGE PUMP PUR Starts purge Pump infuses or withdraws at the top speed depending on the pumping direction STP command or Start Stop key will stop the pump STOP PUMPING PROGRAM STP If the Pumping Program is operating the pump will be stopped and the Pumping Program will be paused If the Pumping Program is paused the stop command will cancel the pause and reset the Pumping Program VOLUME DISPENSED DIS Queries volume dispensed only Set not applicable Response I float W float volume units Where I lt float gt refers to the infusion volume dispensed and W lt float gt refers to the withdrawn volume CLEAR VOLUME DISPENSED CLD INFI WDR Sets the Infused or withdrawn volume dispensed to 0 Command is only valid while the Pumping Program is not operating Query is not applicable INF Infusion volume WDR Withdrawn volume Query is not applicable 8 5 3 Configuration and Setup Comma
80. syringe refill function and starts the whole program over Rate Volume Direction 1500 0 mL hr 50 mL Withdraw Publication 1200 02 23 09 18 14 Phase Function RAT q New Era Pump Systems Inc www SyringePump com Model NE 500 NE 501 Multi Phaser Phase Function 2 LPS Function PRI Function PRL O1 Function Rate Direction RAT 100 0 mL hr Infuse Function JMP 12 Function PRL 02 Function Rate Direction RAT 500 0 mL hr Infuse Function JMP 12 Function 10 PRL 03 Function Rate Direction 11 RAT 750 0 mL hr Infuse Function 12 LOP 05 Function 13 JMP 01 7 4 8 Example 8 Dispensing with Complex Synchronization Restart on Event Trigger or 10 seconds Repeat if Program Input Infuse until Event Trigger Infuse TTLHigh TTL Low TTL Program Ouput Withdraw Event Trigger This example demonstrates a complex interaction with external equipment such as synchronizing with another syringe pump The Program includes a variety of interactions with external equipment which demonstrates the various control possibilities of the NE 500 501 The Pumping Program begins by canceling any previous event traps PHASE 01 and raising the Program Publication 1200 02 24 09 18 14 New Era Pump Systems Inc www SyringePump cOm Model NE 500 NE 501 Multi Phaser Output TTL line PHASE 02 After 5 0 mL has been dispensed at 800 mL hr PHASE 03
81. t Trigger from Syringe Filled Sensor Jump to Phase 3 The following is an automated dispensing Program for a NE 500 501 syringe pump equipped with a Syringe Filled Sensor attached to the TTL I O connector and a valve system to refill the syringe from a reservoir Itis also assumed that the Power Failure mode is enabled After a power fail restart the pusher block is in an unknown position making it impossible for an automated dispensing system to regain synchronization With a Syringe Filled Sensor the following Pumping Program will automatically synchronize the dispensing system and then continue with the normal dispense Publication 1200 02 22 09 18 14 New Era Pump Systems Inc www SyringePump com Model NE 500 NE 501 Multi Phaser The first 2 Phases set an event trap for a Syringe Filled Sensor and refills the syringe until the sensor is triggered When the sensor triggers the event the pump s pusher block will be synchronized with the Pumping Program It is assumed that the sensor is positioned to refill the syringe with 60 mL A withdraw volume of 61 mL is set as a safety feature After the syringe is refilled one 5 mL dispense is made every 5 hours After 12 dispenses the syringe is refilled using the sensor again Phase Function 1 EVN 03 Function Rate Direction 2 RAT 1000 0 mL hr Withdraw Function 3 LPS Function Rate Volume Direction RAT 200 0 mL hr 5 0 mL Infuse Function
82. t n gt Setting 0 Disabled 1 Enabled When alarms are enabled the buzzer will be sounded as follows Publication 1200 02 9 09 18 14 New Era Pump Systems Inc www SyringePump com Model NE 500 NE 501 Multi Phaser Condition Buzzer Action Alarm condition such as pump motor stalled Steady alarm Any command sent to the pump will stop the alarm 6 5 TTL I O Operational Trigger Default Configuration Command TRG aa aa as below in Settings Configures the default mode of the TTL I O Operational Trigger pin 2 that will control the Pumping Program s operation This default setting can be overridden within a Pumping Program See sec 9 1 TTL I O Operational Controls The 2 letter configuration Setting parameter aa is defined in column Setting as follows Setting RS 232 Command Setting Name Function uas FUN TRG lt n gt lt n gt gt FT 0 Foot Switch Falling edge starts or stops the Pumping Program FH 1 Foot Switch Hold Falling edge starts the Pumping Program Rising edge stops the Pumping Program F 2 FootSwith Rising edge starts or stops the Pumping Program Reversed LE 3 LevelControl Falling edge stops the Pumping Program Rising edge starts the Pumping Program ST 4 Start Only Falling edge starts the Pumping Program T2 5 Start Only Reversed Rising edge starts the Pumping Program SP 6 Stop Only Falling edge stops the Pumping Program P2 7 Stop Only
83. t the Publication 1200 02 1 09 18 14 www SyringePump com Model NE 500 NE 501 Multi Phaser New Era Pump Systems Inc option of New Era Pump Systems Inc a defective unit will be either repaired or replaced This warranty does not cover damage by any cause including but not limited to any malfunction defect or failure caused by or resulting from unauthorized service or parts improper maintenance operation contrary to furnished instructions shipping or transit accidents modifications or repair by the user harsh environments misuse neglect abuse accident incorrect line voltage fire flood other natural disasters or normal wear and tear Changes or modifications not approved by New Era Pump Systems Inc could void the warranty Wearable parts such as drive nuts are not covered by the warranty The foregoing is in lieu of all other expressed warranties and New Era Pump Systems Inc does not assume or authorize any party to assume for it any other obligation or liability 1 4 Packing List The OEM Starter Kit for the NE 500 NE 501 Multi Phaser Programmable Syringe Pump includes the following items e One of the following external unregulated power supply adapters Input One of 120V AC 60 Hz 220V AC 50 Hz 240V AC 50 HZ or other custom specified power supply Output 12V DC 800 mA or compatible regulated power supply e Primary Computer RS 232 interface cable CBL PC PUMP 7 e This User s Manual 2 Ov
84. t will be accepted by the pump regardless of its current address 8 6 Getting Started With RS 232 Before beginning to develop pump control software for a computer first setup and experiment with the pump s communication After attaching the pump to the computer run a terminal emulation Program on the computer A generic terminal emulator supplied as standard software with many computers can be used to communicate with the pump in the Basic communications mode New Era Pump Systems Inc supplies a terminal emulator for demonstration purposes only which allows more complex control of the pump Also this terminal emulator contains a Pump Programming Language PPL which allows Pumping Programs to be developed using symbolic text modified and stored in computer files then uploaded to the pump In addition a Pumping Program generator spreadsheet is available to assist in developing a Pumping Program and to create the text file for uploading to a pump With a generic terminal emulator setup the terminal emulator with the same baud rate as the pump and with an 8 bit data no parity and 1 stop bit 8N1 data frame Set the communications port to the port that is attached to the pump Also enable local echo half duplex and turn flow control off From the terminal emulator you can interactively control the pump by typing in commands on your computer and seeing the pump s responses on your screen This will give you a feel for how the com
85. tinue operation with a different Phase number Some functions can change the order of operation conditionally based on external events Publication 1200 02 11 09 18 14 New Era Pump Systems Inc www SyringePump cOm Model NE 500 NE 501 Multi Phaser 7 1 How to Enter Pumping Programs A Pumping Program can be entered directly from the pump s keypad or uploaded from a computer using PUMPTERM or SyringePumpPro software A Pumping Program can be stored in a text file and edited with any word processor which facilitates development and maintenance of the program A Pumping Program generator spreadsheet is available to assist in developing a Pumping Program and to create the text file for uploading to a pump The program will be saved in non volatile memory It only needs to be loaded once Start by organizing your pumping requirements into specific actions and conditions that can then be programmed into Phases For more advance programming methods common groups of Phases can be grouped together and repeated multiple times using looping and jump functions The current values of the pumping rate optional Volume to be Dispensed and pumping direction all refer to the currently selected Phase Use the command PHN to set the current phase To change the Program Function of the currently selected program phase use the FUN command When finished sending the data for the current Phase use the PHN command to select the next progra
86. um uL Diameter Rate Rate mL Diameter Rate Rate _ mm uL hr pL hr i mm mL hr SGE 5 0 343 282 7 0 004 0 25 2 303 12 74 gas tight 10 0 485 565 3 0 008 0 75 35 294 25 49 25 0 728 12173 0 018 1 4 606 50 99 50 1 03 2549 0 036 2 5 7 284 T2755 100 1 457 5102 0 071 5 10 3 254 9 Hamilton 0 5 0 103 25 49 0 001 10 14 57 510 2 Microliter 1 0 146 51 23 0 001 25 23 03 1274 2 0 206 101 9 0 002 50 21 5 1817 5 0 326 255 4 0 004 100 34 99 2942 Publication 1200 02 45 09 18 14
87. un on Low Level Starts the pump whenever the level is low Run on High Level Starts the pump whenever the level is high Stop on Low Level Stop the pump whenever the level is low Stop on High Level Stop the pump whenever the level is high Event Trap Trigger Redirects a program function Event Trap to be triggered by the trigger input pin When a Stop condition is triggered the Event Trap will be triggered instead of stopping the pump Pump Motor Operating Pin 7 This output provides an external signal indicating when the pump motor is operating This pin is configured with the ROM n setup command When set to 0 the output is only at logic high when the motor is operating pumping When set to 1 the output is logic high when the motor is operating or when the Pumping program is executing a pause timer Otherwise the output is a logic low Pumping Direction Controls Input Pin 3 Output Pin 8 Allows bi directional control of the pumping direction The input pin when activated can be used to change the pumping direction This function therefore is only applicable when the pumping direction change is applicable The function of the input pin is configured with the DIN n command When the mode is set to reciprocating pumps DIN 0 then if the current pumping direction is withdraw a falling edge sets the direction to infuse If the current pumping direction is infuse a rising edge sets the direction to withdraw Otherwise this
88. w SyringePump cOm Model NE 500 NE 501 Multi Phaser This is a special system command that will be accepted by the pump regardless of its current address Once set the pump will only respond to commands with the set address and at the specified baud rate Note Once a special communications mode is set the pump will only respond to commands that are preceded by the character To exit special communication mode reset the address ADR 0 Example ADR Query current address setting ADR 3 Set pump network address to 3 The pump will now only respond to commands with address 3 ADR 5 B 1200 Set the pump network address to 5 and the baud rate to 1200 The command response will be at 1200 baud ENABLE SAFE COMMUNICATIONS MODE SAF time out Set query Safe communications mode setting time out gt n n n time out Valid range 0 to 255 If time out 0 then Basic communication mode is set disabling Safe mode If time out 0 then Safe communications mode is enabled After the reception of this command valid communications must be received every time out seconds FIRMWARE VERSION QUERY VER Response NE50 n V n nnn where n nnn is the current model and firmware version number Set is not applicable MASTER PROGRAM RESET RESET Clears program memory and resets communication parameters to Basic mode and address 0 This is a special system command tha
89. www SyringePump com Model NE 500 NE 501 Multi Phaser 7 3 6 JUMP TO PHASE x 325 sec t troia ALL ELL 13 7 3 7 SUB PROGRAM SELECTION INPUT ieri 13 Lione elei esee su I EUR EG ERIS deoa SUB PROGRAM START LABEL TILL RR D tL NI Rtg NN Ug Du Ud DEFINE STARTING PHASE OF LOOP 7 3 10 DEFINE CONTINUOUS LOOP END iii 14 7 3 11 DEFINE LOOP END AND LOOP REPETITIONS cccceccsscccccsssssssccssccccessssssssessseeess 14 Jesu LIE PAUSE PUMPING pM ET JUMP TO PHASE IF EXTERNAL TRIGGER 7 3 14 SETUP EVENT TRIGGER JUMP PHASE ei 15 7 3 15 SETUP EVENT SQUARE WAVE TRIGGER JUMP PHASE eee 15 Ped TOS eicere eheu ann SETUP EXPANSION PORT EVENT TRIGGER JUMP PHASE dO ba eR SETUP EXPANSION PORT PAUSE AND TRIGGER LEVEL WAIT PHASE 7 3 18 SETUP EXPANSION PORT PAUSE AND TRIGGER EDGE WAIT PHASE 16 PBA EVENT RESET 5 hee te nale IRR 16 PS DO eu HENRI inte A RING II IND CLEAR TOTAL VOLUME DISPENSED 7432 Tra teret EEATT OVERRIDE OPERATIONAL TRIGGER DEFAULT CONFIGURATION 773 297 SEDE TLOUTPUT BIN A nete seti cts ons Sere LA 17 7 3 23 SET TTL EXPANSION PORT OUTPUT PIN LOW iii 17 WS diii erteilen Sees setae SET TTL EXPANSION PORT OUTPUT PIN HIGH 419 259 a e ee eo RR or ede DT AE DEI HE a e deus BEEP 7 4 PUMPING PROGRAM EXAMPLES eeee eee ee eee en eee e tnos esee tnos eese ense esee en ee seen sees e ense esta 18 7 4 1 EXAMPEE4 2 STEP RATE eee aaa 1
90. y and resets setup Network Command Burst gt n command Network Command Burst Communicate with multiple pumps on a pump network simultaneously Any command preceded by the asterisk symbol bypasses the pump network address and Safe mode 10 2 RS 232 Pump Network Connector Wiring RS 232 To Network To Computer V V L IL LL DI DODO RCV from network TXD to computer TXD to network L RCV from computer PC Com Port Connectors 25 Pin 9 Pin 3 Receive 2 Receive Connect to pump TXD 2 Transmit 3 Transmit Connect to pump RCV 9 Ground 5 Ground Connect to pump GND 10 3 Accessories 10 3 1 ANA BOX Part ADPT ANABOX Analog voltage control interface Allows the pump to be controlled by a variable voltage source Allows the Creation of a closed loop system allowing the NE 1000 to be controlled by an external sensor such as a pressure sensor or other variable voltage source Start or stop the pump at a specific voltage level Set the pumping rate to be proportional to the voltage input 10 3 2 Syringe Heater Part SYRINGE HEATER see www SyringeHeater com for details Flexible heating pad that wraps around the syringe Thermo Kinetic Heat Clamping digital controller will heat a syringe to a set temperature up to 100 C 10 3 3 RS 232 Network Cables RS 232 Network Primary Cable

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