User Manual - Beckman Coulter
Contents
1. lt Powering On Off the Instrument 13 Using the Main Door and Access Panels 14 Main Door 14 Opening the Main Door 14 Closing the Main Door 16 Back Access Panels 16 Removing the Back Access Panels 17 Installing the Back Access Panels 18 Connections and Tubing 19 Side Access Panel 24 Removing the Side Access Panel 24 Installing the Side Access Panel 24 Accessing Disposal Accessory Bags 25 Integration Deck Door 25 Maintenance 26 Cleaning the Enclosure System 26 Troubleshooting 26 Beckman Coulter Inc Warranty and Returned Goods Requirements Xiv Illustrations Illustrations RB OO N 10 Lai 12 13 14 15 16 gt 18 19 20 21 22 Main Components of the Biomek 4000 Enclosure System and In strument 2 Potential Pinch Points 3 Lifting Points Front Rail View 4 Lifting Points Rear Support View 4 Instrument STOP Button 6 Dimensions Front View Enclosure System Without Integra tion Deck Installed 9 Dimensions Side View Biomek 4000 Instrument With Enclo sure System Only 10 Dimensions Front View Enclosure System With Integration Deck Installed 11 Dimensions Side View Biomek 4000 Instrument With Enclo sure System and Integration Deck 12 Main Door Handle 15 Main Door Opening 15 Main Door Closing 16 Back Access Panel Removal 17 Back Access Panel Installation 18 Accessing Connections 19 Cable Connections 20 Wash S2. Issue Remedy 1 Ensure you are using a Biomek 3000 4000 Side Module 2 R th feet from the Side Module The Side Module cannot be sh Side Module installed onto the deck REMOVE TIS BACK ATERS 4 IfSteps 1 through 3 did not resolve the installation problems for the Side Module contact a Beckman Coulter Representative 1 Open the main door as it could be slightly obstructing the view of the deck 2 Refer to the Biomek 4000 Hardware Manual Chapter 7 Framing for additional information on framing the deck You are having trouble framing 1 Ensure the tip disposal bag is unencumbered and flat Tips are not being discarded into Refer to the Biomek 4000 ALPs and Accessories Manual Chapter the tip disposal bag 8 Disposal Accessory for additional information on using the disposal accessory The temperature within the Monitor the temperature inside the enclosure when using heat enclosure is too high causing your generating ALPs OR contact a Beckman Coulter Representative for assay to fail alternatives 26 PN B28615AB Using the Biomek 4000 Enclosure System Troubleshooting Table 5 Biomek 4000 Enclosure System Troubleshooting Issue You are having trouble installing cables ALP tubing or accessories The main door seems too heavy to lift The main door falls shut The main door slams open at the top of its travel The main enclosure door rubs on the side
3. Understanding and Using Project Files e Creating and Modifying Tip and Labware Types Understanding and Creating Liquid Types Understanding and Creating Techniques Using the Pipetting Template Editor Creating Well Patterns Creating and Using Methods Using Variables and Expressions in a Method Using Sample Tracking and Data Sets in a Method Using the Basic Step Palette Using the Intermediate Step Palette Using the Advanced Step Palette Using the Span 8 Step Palette Using the Biomek Instrument Step Palette Using the Specialty Step Palette Using the Devices Step Palette Using the Wash Tool Step Palette Using the DataSets Step Palette Handling and Preventing Errors Generating and Using Log Data Using Manual Control Scripting e Changing Window Appearance Biomek 4000 Migration Guide for Biomek 3000 Methods PN B08853 e Migrating Methods Biomek 4000 System Updates Continued Features Discontinued Features Shaking Peltier ALP Instruction Manual for Biomek 4000 Instruments PN B20570 Overview of Shaking Peltier ALP Hardware Installation Software Installation _ Software Setup e Framing Using AccuFrame e Installing Adapter Plates and Creating Labware Offsets e Operations Static Peltier ALP Instruction Manual for Biomek 4000 Instruments PN B20569 Overview of Static Peltier ALP e Hardware Installation __ So
4. g 5 g Mfg Date China RoHS Environmental Label This label indicates that the electronic information product does not contain any toxic or hazardous substances The center indicates the product is Environmentally safe and does not have an Environmentally Friendly Useful Period EFUP date therefore can safely be in use indefinitely The circling arrows indicate the product is recyclable The date code on the label or product indicates the date of manufacture 43048 28615 Safety Notice RoHS Notice xii PN B28615AB Contents gt Revision History iii Safety Notice v Overview V Alerts for Warning Caution Important and Note v Instrument Safety Precautions vi Electrical Safety vii High Voltage vii Laser Light vii Disposal of Electronic Equipment viii Chemical and Biological Safety viii Moving Parts x Cleaning x Maintenance x RoHS Notice xi China RoHS Caution Label xi China RoHS Environmental Label xi Using the Biomek 4000 Enclosure System 1 Introduction 1 Safety Considerations 3 Improper Use of the Enclosure System 3 Exposure to Heat Flame 3 Potential Pinch Points 3 Lifting the Instrument 4 Lifting the Instrument Enclosure System 4 Lifting the Instrument Enclosure System Integration Deck 5 Stopping the Instrument 6 Best Practices When Automating With the Enclosure 7 Weight and Space Requirements 8 xiii
5. omissions or otherwise The entire risk as to the use results and performance of this system and related documentation is assumed by the user PN B28615AB Warranty 2 www beckmancoulter com A COULTER BECKMAN Related Documents Biomek 4000 Hardware Manual PN A99498 Moving and Installing the Biomek 4000 Workstation e Setting Up the Worksurface Pipetting Tools e Gripper Tool Hardware Setup Framing Controlling the Workstation Biomek 4000 Preinstallation Manual PN A99499 Preinstallation Requirements Biomek 4000 ALPs and Accessories Manual PN A99501 1 1 Standard ALP e Auto Latching Tip Rack Holders Code Reader Code Reader Hand Held Circulating Reservoir e Filtration System Liquid Waste Station Off Deck Platform Orbital Shaker Test Tube Racks Thermal Exchange Unit e Wash Unit Biomek 4000 Software Tutorial PN A99502 Getting Started with Biomek Software Using More Steps ina Method Using Worklists and Conditions Using Files to Direct Transfers Biomek 4000 Customer Start Up Guide PN A99598 Biomek 4000 Laboratory Automation Workstation e Preparing to Run e Creating a Simple Method e Advanced Features e Best Practices Biomek 4000 Software Manual PN B08852 Using Accounts and Permissions Using Password Protection Using Instrument Files and Settings Configuring Hardware Setup e Preparing and Managing the Deck
6. w Top access clearance 30 5 d 12 0 d NOTE The dimensions for the lab bench in does not include space for the automation controller or for additional accessories accessory dimensions can be found in the Biomek 4000 Preinstallation Manual A lab bench with shelving for accessories underneath the instrument is desirable Rear access Clearance means the distance between the rear of the instrument and the wall or any other permanent structure NOTE The power plug serves as the Disconnecting Device and must remain easily accessible Side access clearance means the distance between the side of the instrument and the wall or any other permanent structure Front access clearance means the distance required in front of the instrument with the Integration Deck door fully extended Front access clearance is only applicable to workstations with the optional Integration Deck ee Top access clearance means the distance required above the instrument 8 PN B28615AB PN 28615 Using the Biomek 4000 Enclosure System Weight and Space Requirements Table 2 Actual Dimensions Base Instrument Closed Enclosure System 130 0 w x 53 5 d x 70 0 h 51 2 w x 21 1 d x 27 6 h see Figure 6 Base Instrument Open Enclosure System 130 0 w x 78 7 d x 94 4 h 51 2 w x 31 0 d x 37 2 h see Figure 7 Base Instrument Closed Enclosure System Closed Integration Deck see Figure 8 130 0 w x 53 5 d
7. Coulter Representative Accessory Integration Standard Biomek 4000 ALPs and accessories can be used with the Enclosure System These accessories are integrated and connected through access panels located on the back and the side of the Enclosure System Using the Biomek 4000 Enclosure System Introduction Features The Enclosure System features the following main components Main Door which is designed to be opened with one hand allowing the operator to use the other hand to make quick changes on the deck Removable panels including Side Access Panel left side only which allows access to accessories such as the conveyor or the Disposal Accessory Back Access Panels left and right which allows access to the power switch and ALPs and accessories including but not limited to the Static Peltier ALP Shaking Peltier ALP Liquid Waste System Orbital Shaker ALP and the AccuFrame device The Enclosure System main door and all panels are constructed from translucent polymer allowing you to easily view the progress of your assay Figure 1 depicts the main features of the Enclosure System as well as some of the main features of the Biomek 4000 Laboratory Automation Workstation Figure 1 Main Components of the Biomek 4000 Enclosure System and Instrument Deck Instrument STOP Button Pipetting Tool Side Access Panel Left Back Access Panel Main Door Right Back Access Panel Integration Deck Access D
8. System only i e an Integration Deck is not installed follow the instructions in Lifting the Instrument Enclosure System Ifthe instrument is equipped with both the Enclosure System and the Integration Deck it is too heavy to move as a unit See Lifting the Instrument Enclosure System Integration Deck for details Lifting the Instrument Enclosure System Four people are needed to lift the Biomek 4000 Laboratory Automation Workstation when equipped with an Enclosure System Failure to use four people could result in bodily injury and or damage to the workstation The workstation should always be lifted by grasping below the front rails and bottom of the rear supports Four people are needed to lift and move the instrument and Enclosure System as the total weight is 70 8 kg 156 0 lbs without the deck plate or any accessories Figure 3 and Figure 4 show the lifting points for the four representatives required to lift the instrument Figure 3 Lifting Points Front Rail View Figure 4 Lifting Points Rear Support View L Lo o R 1 First Representative Right Hand Lifting Point 3 Third Representative Right Hand Lifting Point 2 Second Representative Left Hand Lifting Point 4 Fourth Representative Left Hand Lifting Point PN B28615AB Using the Biomek 4000 Enclosure System Safety Considerations Lifting the Instrument Enclosure System Integration Deck Four people are needed to lift the Biomek 4000 Laboratory Automati
9. cover Remedy Remove the Back Access Panel 1 Check for obstructions 2 Contact a Beckman Coulter Representative as the main door might need to be adjusted Contact a Beckman Coulter Representative as the main door might need to be adjusted Contact a Beckman Coulter Representative as the main door might need to be adjusted Contact a Beckman Coulter Representative as the main door might need to be adjusted PN B28615AB 27 Using the Biomek 4000 Enclosure System Troubleshooting 28 PN B28615AB PN 28615 Beckman Coulter Inc Warranty and Returned Goods Requirements All standard Beckman Coulter Inc policies governing returned goods apply to this product Subject to the exceptions and upon the conditions stated below the Company warrants that the products sold under this sales agreement shall be free from defects in workmanship and materials for one year after delivery of the products to the original Purchaser by the Company and if any such product should prove to be defective within such one year period the Company agrees at its option either 1 to correct by repair or at the Company s election by replacement any such defective product provided that investigation and factory inspection discloses that such defect developed under normal and proper use or 2 to refund the purchase price The exceptions and conditions mentioned above are as follows 1 Components or accessories manufactured by
10. injury if All doors covers and panels are not closed and secured in place prior to and during instrument operation The integrity of safety interlocks and sensors is compromised You contact moving parts You mishandle broken parts Doors covers and panels are not opened closed removed and or replaced with care Improper tools are used for troubleshooting To avoid injury Keep doors covers and panels closed and secured in place while the instrument is in use Take full advantage of the safety features of the instrument Do not defeat safety interlocks and sensors Acknowledge and act upon instrument alarms and error messages Keep away from moving parts Report any broken parts to your Beckman Coulter Representative Use the proper tools when troubleshooting System integrity could be compromised and operational failures could occur if vi This equipment is used in a manner other than specified Operate the instrument as instructed in the Product Manuals You introduce software that is not authorized by Beckman Coulter into your computer Only operate your system s computer with software authorized by Beckman Coulter You install software that is not an original copyrighted version Only use software that is an original copyrighted version to prevent virus contamination PN B28615AB Safety Notice Electrical Safety If you purchased this product from anyone other than Beckman Coulter or an authorized Beckm
11. main door the left and right Back Access Panels and the Side Access Panel which is located on the left side of the instrument Refer to the following sections for complete instructions Main Door Back Access Panels Side Access Panel Main Door The main door allows access to the Biomek 4000 instrument deck and instrument components Operating the main door is simple Details are available in the following sections Opening the Main Door Closing the Main Door Opening the Main Door Risk of personal injury The instrument remains in operation when the Enclosure System door is opened Use the instrument STOP button Figure 5 to halt the instrument ALPs and accessories Risk of equipment damage Opening or closing the main door from the left or the right of the center handle could damage the Enclosure System When maneuvering the main door pull from the center handle only Risk of personal injury When opening or closing the main door do not release the door until it is fully open or fully closed A partially open door could slam shut causing injury 14 PN B28615AB Using the Biomek 4000 Enclosure System Using the Main Door and Access Panels To open the Biomek 4000 Enclosure System main door With your palm facing down pull the handle out and up Figure 10 and then gently push the door back in one smooth motion Figure 11 Figure 10 Main Door Handle Figure 11 Main Door Opening PN B28615AB
12. x 87 2 h 51 2 x 21 1 d x 34 3 h Base Instrument Open Enclosure System Integration Deck see Figure 9 130 0 w x 78 7 d x 111 7 h 51 2 w x 31 0 d x 44 0 h Figure 6 Dimensions Front View Enclosure System Without Integration Deck Installed 70 0 cm 27 6 in 130 0 cm 51 2 in Using the Biomek 4000 Enclosure System Weight and Space Requirements Figure 7 Dimensions Side View Biomek 4000 Instrument With Enclosure System Only 78 7 cm 31 0 in 94 4cm 37 2 in 9 0 cm 3 5 in 48 0 cm 18 9 in 62 5 cm 24 6 in 10 PN B28615AB PN 28615 Using the Biomek 4000 Enclosure System Weight and Space Requirements Figure 8 Dimensions Front View Enclosure System With Integration Deck Installed 87 2 cm 34 3 in 130 0 cm 51 2 in 11 Using the Biomek 4000 Enclosure System Weight and Space Requirements Figure 9 Dimensions Side View Biomek 4000 Instrument With Enclosure System and Integration Deck 78 7 cm 31 0 in z 7 N 4 4 A I i l y l 1 I 111 7cm 44 0 Including 4 feet Z 9 0 cm 3 5 in 48 0 cm 18 9 in 18 0 cm 7 1 in 75 0 cm 29 5 in 12 PN B28615AB Using the Biomek 4000 Enclosure System Powering On Off the Instrument The Biomek 4000 Laboratory Automation Workstation Enclosure System and all ALPs and accessor
13. 15 Using the Biomek 4000 Enclosure System Using the Main Door and Access Panels Closing the Main Door Risk of equipment damage Opening or closing the main door from the left or the right of the center handle could damage the Enclosure System When maneuvering the main door pull from the center handle only To close the Biomek 4000 Enclosure System main door With your palm facing down pull the handle forward Figure 12 and then gently push the door down in one smooth motion Figure 12 Main Door Closing Back Access Panels There are two Back Access Panels one is located on the left side of the instrument and the other on the right These panels provide access to the instrument communication ports and tubing egress to allow easy integration with Biomek 4000 ALPs and accessories including but not limited to the following e AccuFrame Liquid Waste Station Orbital Shaker Shaking Peltier Static Peltier Wash System 16 PN B28615AB Using the Biomek 4000 Enclosure System Using the Main Door and Access Panels Connecting and accessing the tubing and cabling required for using most Biomek 4000 ALPs and accessories is achieved through the right Back Access Panel Refer to Connections and Tubing for details For a complete list of accessories refer to the Biomek 4000 ALPs and Accessories Manual Biomek 4000 Hardware Manual Shaking Peltier ALP Instruction Manual for Biomek 4000 Instruments or the St
14. Enclosure System Using the Main Door and Access Panels Accessing Disposal Accessory Bags Disposal Accessory bags are accessed through the Side Access Panel see Figure 21 for details Figure 21 Accessing Disposal Accessory Bags Integration Deck Door To open the Integration Deck door Pull on one side of the door to disengage the magnetic latches and gently push the door down as shown in Figure 22 Figure 22 Integration Deck Door Opening gt PN B28615AB 25 Using the Biomek 4000 Enclosure System Maintenance Maintenance Other than routine cleaning see Cleaning the Enclosure System consult your Beckman Coulter Service Representative to complete any necessary maintenance activities Cleaning the Enclosure System To clean your Enclosure System it is recommended that you use one of the solutions listed below IMPORTANT Cleaning solutions should not remain in contact with the Enclosure System for more than 30 minutes 10 Bleach 70 Ethanol 8 Formaldehyde Troubleshooting If you are having trouble with your Biomek 4000 Enclosure System consult Table 5 for common issues along with their resolutions IMPORTANT If an issue lists multiple remedies start with Step 1 If the problem is not resolved continue progressing through the steps until the problem is corrected or until you are prompted to contact a Beckman Coulter Representative Table 5 Biomek 4000 Enclosure System Troubleshooting
15. User Manual Biomek 4000 Laboratory Automation Workstation Enclosure System PN B28615AB May 2013 Manufactured for Beckman Coulter Inc 250 S Kraemer Blvd Brea 92821 U S A ULTER Biomek 4000 Enclosure System User Manual PN B28615AB May 2013 2013 Beckman Coulter Inc All rights reserved Trademarks BECKMAN COULTER the stylized logo and Biomek are trademarks of Beckman Coulter Inc and are registered with the USPTO All other trademarks service marks products or services are trademarks or registered trademarks of their respective holders Find us on the World Wide Web at www beckmancoulter com Made in USA Printed in USA Revision History For labeling updates go to www beckmancoulter com and download the latest version of the manual 03 13 Initial Issue AA 05 2013 AB Added a Troubleshooting section PN B28615AB Revision History PN B28615AB Safety Notice Overview Read all product manuals and consult with Beckman Coulter trained personnel before attempting to operate the instrument Do not attempt to perform any procedure before carefully reading all instructions Always follow product labeling and manufacturer s recommendations If in doubt as to how to proceed in any situation contact your Beckman Coulter Representative Beckman Coulter Inc urges its customers and employees to comply with all national health and safety standards such as th
16. above warranty shall be in lieu of all warranties of fitness and of the warranty of merchantability and that the company shall have no liability for special or consequential damages of any kind or from any cause whatsoever arising out of the manufacture use sale handling repair maintenance or replacement of any of the products sold under the sales agreement Representatives and warranties made by any person including dealers and representatives of the Company which are consistent or in conflict with the terms of this warranty shall not be binding upon the Company unless reduced in writing and approved by an expressly authorized officer of the Company Parts replaced during the warranty period are warranted to the end of the instrument warranty Warranty 1 Beckman Coulter Inc Warranty and Returned Goods Requirements NOTE Performance characteristics and specifications are only warranted when Beckman Coulter replacement parts are used Except as provided in writing signed by an officer to Beckman Coulter Inc this system and any related documentation are provided as is without warranty of any kind expressed or implied including that the system is error free This information is presented in good faith but Beckman Coulter does not warrant guarantee or make any representations regarding the use or the results of the use of this system and related documentation in terms of correctness accuracy reliability currentness
17. an Coulter distributor and if it is not presently under a Beckman Coulter Service Maintenance Agreement Beckman Coulter cannot guarantee that the product is fitted with the most current mandatory engineering revisions or that you will receive the most current information bulletins concerning the product If you purchased this product from a third party and would like further information concerning this topic contact your Beckman Coulter Representative Electrical Safety To prevent electrically related injuries and property damage properly inspect all electrical equipment prior to use and immediately report any electrical deficiencies Contact a Beckman Coulter Representative for any servicing of equipment requiring the removal of covers or panels High Voltage This symbol indicates the potential of an electrical shock hazard existing from a high voltage source and that all safety instructions should be read and understood before proceeding with the installation maintenance and servicing of all modules Do not remove system covers To avoid electrical shock use supplied power cords only and connect to properly grounded three holed outlets Laser Light PN B28615AB This symbol indicates that a potential hazard to personal safety exists from a laser source When this symbol is displayed in this manual pay special attention to the specific safety information associated with the symbol Laser Specifications Laser Type Clas
18. atic Peltier ALP Instruction Manual for Biomek 4000 Instruments Removing the Back Access Panels IMPORTANT If the Biomek 4000 Bridge and Pod are positioned in front of a Back Access Panel move them to another location before attempting to remove the panel Lift 1 and tip forward 2 the Back Access Panel to remove from instrument as shown in Figure 13 NOTE This procedure is the same for both the left and right Back Access Panels Figure 13 Back Access Panel Removal PN B28615AB 17 Using the Biomek 4000 Enclosure System Using the Main Door and Access Panels Installing the Back Access Panels IMPORTANT If the Biomek 4000 Bridge and Pod are positioned in front of a Back Access Panel opening move them to another location before attempting to install the panel 1 Align the holes with the location pins on the back frame 2 Push the panel toward the back of the instrument to engage the shoulder screw on the side and secure it into place against the magnet as shown in Figure 14 NOTE This procedure is the same for both the left and right Back Access Panels Figure 14 Back Access Panel Installation PN B28615AB PN 28615 Using the Biomek 4000 Enclosure System Using the Main Door and Access Panels Connections and Tubing This section specifies the panels that need to be accessed for connecting ALPs and accessories to your Biomek 4000 instrument For complete instructions on using Biomek 4000 ALPs an
19. d accessories refer to the Biomek 4000 ALPs and Accessories Manual Biomek 4000 Hardware Manual Shaking Peltier ALP Instruction Manual for Biomek 4000 Instruments or the Static Peltier ALP Instruction Manual for Biomek 4000 Instruments Accessing the Connection Ports Connection ports can be accessed from the front once the right Back Access Panel is removed see Figure 15 Risk of personal injury or equipment damage Turn off power to the Biomek 4000 Laboratory Automation Workstation before attaching or removing ALPs or accessories Failure to do so can cause electrical shock or equipment damage Figure 15 Accessing Connections 19 Using the Biomek 4000 Enclosure System Using the Main Door and Access Panels Connecting Cables Refer to Figure 16 for the location of the right Back Access Panel pass through to allow appropriately connecting ALPs and accessory cables Figure 16 Cable Connections 1 Opening on the right Back Access Panel for cable connections 2 Cables can also be routed through the opening in this location 20 PN B28615AB PN B28615AB Using the Biomek 4000 Enclosure System Using the Main Door and Access Panels Routing Wash System Tubing Figure 17 and Figure 18 show the appropriate method for connecting wash system tubing Figure 17 Wash System Tubing Rear Panel 1 Top Rear Panel 2 Wash Tubing 21 Using the Biom
20. e use of barrier protection This may include but is not limited to protective eyewear gloves and suitable laboratory attire when operating or maintaining this or any other automated laboratory instrumentation If the equipment is used in a manner not specified by Beckman Coulter Inc the protection provided by the equipment may be impaired Alerts for Warning Caution Important and Note PN B28615AB All Warnings and Cautions in this document include an exclamation point framed within a triangle The exclamation point symbol is an international symbol which serves as a reminder that all safety instructions should be read and understood before installation use maintenance and servicing are attempted WARNING indicates a potentially hazardous situation which if not avoided could result in death or serious injury CAUTION indicates a potentially hazardous situation which if not avoided may result in minor or moderate injury It may also be used to alert against unsafe practices IMPORTANT IMPORTANT is used for comments that add value to the step or procedure being performed Following the advice in the Important adds benefit to the performance of a piece of equipment or to a process NOTE NOTE is used to call attention to notable information that should be followed during installation use or servicing of this equipment Safety Notice Instrument Safety Precautions Instrument Safety Precautions Risk of operator
21. ek 4000 Enclosure System Using the Main Door and Access Panels Figure 18 Wash System Tubing Wash Tool Tube Assembly 1 Wash Tool Tubing Assembly 2 Pod Assembly 22 PN B28615AB PN 28615 Using the Biomek 4000 Enclosure System Using the Main Door and Access Panels Routing Liquid Waste Tubing Refer to Figure 19 for the location of the left Back Access Panel pass through to allow appropriately connecting the Liquid Waste tubing Figure 19 Liquid Waste Tubing p7 1 Liquid Waste Station 2 Liquid Waste Tubing 3 Opening for Tubing Connection 23 Using the Biomek 4000 Enclosure System Using the Main Door and Access Panels Side Access Panel 24 The Side Access Panel is typically used to access Disposal Accessory bags see Accessing Disposal Accessory Bags as well as to integrate devices such as a conveyor For a complete list of accessories refer to the Biomek 4000 ALPs and Accessories Manual Biomek 4000 Hardware Manual Shaking Peltier ALP Instruction Manual for Biomek 4000 Instruments or the Static Peltier ALP Instruction Manual for Biomek 4000 Instruments Removing the Side Access Panel e Unscrew the knob to remove the Side Access Panel as shown in Figure 20 Figure 20 Access Panel Side Removal amp Installing the Side Access Panel Tighten the Side Access Panel knob turning it in the opposite direction indicated in Figure 20 PN B28615AB Using the Biomek 4000
22. f personal injury The instrument remains in operation when the Enclosure System door is opened Use the instrument STOP button Figure 5 to halt the instrument and ALPs Rubber feet and the Back Access Panels see Back Access Panels for location of these panels need to be removed before attempting to install the side modules When framing the deck open the main door to prevent an obstructed view during the process Ensure the tip disposal bag is unencumbered and flat allowing the bag to capture as many used tips as possible PN B28615AB 7 Using the Biomek 4000 Enclosure System Weight and Space Requirements Weight and Space Requirements A minimum of 30 5 cm 1 ft of additional space should be available to the left right and above the instrument see Table 1 for details Table 2 provides the actual dimensions for the Biomek 4000 Laboratory Automation Workstation Enclosure System Table 1 Space Required Dimensional Footprint Component width x depth x height cm Minimum Bench Necessary 132 0 cm w x 56 0 cm d 52 0 in w x 22 0 d Base Instrument Enclosure System 191 0 w x 101 8 d x 100 5 h 75 2 w x 40 1 d x 39 6 h Base Instrument Enclosure System 191 0 w x 101 8 d x 117 7 h 75 2 w x 40 1 d x 46 3 h Integration Deck Rear access clearance 30 5 d 12 0 d Side access clearance 30 5 w 12 0 w Front access clearance 17 8 w 7 0
23. ftware Installation Software Setup Framing Using AccuFrame e Installing Adapter Plates and Creating Labware Offsets e Operations 2013 Beckman Coulter Inc All Rights Reserved
24. ies must be installed on a level and stable working surface capable of supporting the weight of your specific setup see Table 3 for details without bowing by more than 6 35 mm 1 8 in Table 3 Weight Specifications Weight Component fe kg Ibs Base Instrument 40 8 90 0 Enclosure System 30 0 66 0 Total Weight 70 8 156 0 Base Instrument 40 8 90 0 Enclosure System 31 7 70 0 Integration Deck 15 0 33 0 Total Weight 87 5 193 0 1 Includes additional hardware required for installing the Enclosure System with the Integration Deck Temperature and humidity restrictions are listed in Table 4 Table 4 Environmental Specifications Item Specification Operating Temperature 5 30 C 41 86 F Operating Humidity lt 85 non condensing at 30 C 86 F Powering On Off the Instrument To turn the instrument on or off when standing in front of the instrument Remove the left Back Access Panel see Removing the Back Access Panels this allows access to the On Off switch from the front of the instrument NOTE If you are standing behind the instrument it is not necessary to remove the left Back Access Panel NOTE The power plug serves as the Disconnecting Device and must remain easily accessible PN B28615AB 13 Using the Biomek 4000 Enclosure System Using the Main Door and Access Panels Using the Main Door and Access Panels The Enclosure System contains three main components the
25. l or formaldehyde use barrier protection including protective eyewear gloves and suitable laboratory attire Refer to the Safety Data Sheet for details about chemical exposure before using the chemical viii PN B28615AB Safety Notice Chemical and Biological Safety Before running with chemistry or any biological samples new labware types will require testing to determine if labware offsets are necessary to move to or from the Peltier ALP or to access the labware during pipetting operations while on the Peltier ALP If you do not do the required testing the labware could crash and the contents could spill if the offset is incorrect Normal operation of the instrument may involve the use of materials that are toxic flammable or otherwise biologically harmful When using such materials observe the following precautions Handle infectious samples according to good laboratory procedures and methods to prevent the spread of disease Observe all cautionary information printed on the original solutions containers prior to their use Dispose of all waste solutions according to your facility s waste disposal procedures Operate the instrument in accordance with the instructions outlined in this manual and take all the necessary precautions when using pathological toxic or radioactive materials Splashing of liquids may occur therefore take appropriate safety precautions such as using safety glasses and wearing protective cl
26. on Workstation when equipped with an Enclosure System Failure to use four people could result in bodily injury and or damage to the workstation The workstation should always be lifted by grasping below the front rails and bottom of the rear supports Do not attempt to lift the Biomek 4000 Laboratory Automation Workstation with both the Enclosure System and Integration Deck attached as this configuration is too heavy and unstable to move safely and attempting to do so could result in bodily injury and or damage to the workstation The Integration Deck must be removed by your Beckman Coulter Representative prior to moving the instrument PN B28615AB 5 Using the Biomek 4000 Enclosure System Safety Considerations Stopping the Instrument Press the instrument STOP button on the front rail of the Biomek 4000 instrument to stop movement of the bridge pod and tools Figure 5 Instrument STOP Button 1 Instrument STOP Button 6 PN B28615AB Using the Biomek 4000 Enclosure System Best Practices When Automating With the Enclosure Best Practices When Automating With the Enclosure Be aware of the following when using the Enclosure System with your Biomek 4000 Laboratory Automation Workstation Risk of assay failure When used with heat generating ALPs and or accessories a closed Enclosure System can cause the ambient temperature to exceed limits required by temperature sensitive assays Regularly monitor the temperature Risk o
27. oor PN 28615 Using the Biomek 4000 Enclosure System Safety Considerations Safety Considerations In addition to the general Biomek 4000 Laboratory Automation Workstation safety information see Safety Notice the sections below provide additional safety instructions when using your instrument with the Enclosure System Improper Use of the Enclosure System Risk of personal injury or contamination Do not store items such as reagents biohazardous material or chemicals on top of the enclosure as this could result in a hazardous substance spill Store all substances in proper locations Exposure to Heat Flame This Enclosure System although constructed using metallic or flame rated material is NOT intended to act as an enclosure that can contain or limit the spread of fire Observe the appropriate cautionary procedures as defined by your safety officer when using flammable solvents in or near a powered up instrument Potential Pinch Points Risk of bodily harm Fingers or hands could become pinched in the Enclosure System Keep fingers and hands clear of the potential pinch points shown in Figure 2 when opening and closing the door Figure 2 Potential Pinch Points A PN B28615AB 3 Using the Biomek 4000 Enclosure System Safety Considerations Lifting the Instrument When preparing to move the instrument consider the following Ifthe instrument is equipped with the Enclosure
28. othing when working with potentially hazardous liquids Use an appropriately contained environment when using hazardous materials Observe the appropriate cautionary procedures as defined by your safety officer when using flammable solvents in or near a powered up instrument Observe the appropriate cautionary procedures as defined by your safety officer when using toxic pathological or radioactive materials NOTE Observe all warnings and cautions listed for any external devices attached or used during operation of the instrument Refer to applicable external device user s manuals for operating procedures of that device NOTE For Safety Data Sheets SDS MSDS information go to the Beckman Coulter website at www beckmancoulter com PN B28615AB Safety Notice Moving Parts Moving Parts Risk of personal injury To avoid injury due to moving parts observe the following Never attempt to exchange labware reagents or tools while the instrument is operating Never attempt to physically restrict any of the moving components of the instrument Keep the instrument work area clear to prevent obstruction of the movement Cleaning Observe the cleaning procedures outlined in this user s manual for the instrument Prior to cleaning equipment that has been exposed to hazardous material Contact the appropriate Chemical and Biological Safety personnel e Review the Chemical and Biological Safety information in the
29. s II Laser Diode e Maximum Output 11 mW Wavelength 670 nm vii Safety Notice Chemical and Biological Safety Disposal of Electronic Equipment It is important to understand and follow all laws regarding the safe and proper disposal of electrical instrumentation The symbol of a crossed out wheeled bin on the product is required in accordance with the Waste Electrical and Electronic Equipment WEEE Directive of the European Union The presence of this marking on the product indicates That the device was put on the European Market after August 13 2005 and That the device is not to be disposed via the municipal waste collection system of any member state of the European Union For products under the requirement of WEEE directive please contact your dealer or local Beckman Coulter office for the proper decontamination information and take back program which will facilitate the proper collection treatment recovery recycling and safe disposal of device Chemical and Biological Safety Ifa hazardous substance such as blood is spilled onto the instrument ALPs or accessories clean up the spill by using a 10 bleach solution or use your laboratory decontamination solution Then follow your laboratory procedure for disposal of hazardous materials If the instrument ALPs or accessories need to be decontaminated contact your Beckman Coulter Representative Risk of chemical injury To avoid contact with the bleach ethano
30. the Company which by their nature are not intended to and will not function for one year are warranted only to reasonable service for a reasonable time What constitutes a reasonable time and a reasonable service shall be determined solely by the Company A complete list of such components and accessories is maintained at the factory 2 Company makes no warranty with respect to components or accessories not manufactured by it In the event of defect in any such component or accessory the Company will give reasonable assistance to Purchaser in obtaining the manufacturer s own warranty 3 Any product claimed to be defective must if required by the Company be returned to the factory properly decontaminated of any chemical biological or radioactive hazardous material transportation charges prepaid and will be returned to the Purchaser with transportation charges collect unless the product is found to be defective 4 The Company shall be released from all obligations under all warranties either expressed or implied if any product covered hereby is repaired or modified by persons other than its own authorized service personnel unless such repair by others is made with the written consent of the Company 5 Ifthe product is a reagent or the like it is warranted only to conform to the quantity and content and for the period but not in excess of one year stated on the label at the time of delivery It is expressly agreed that the
31. user s manual Maintenance Perform only the maintenance described in this manual Maintenance other than that specified in this manual should be performed only by service engineers IMPORTANT It is your responsibility to decontaminate components of the instrument before requesting service by a Beckman Coulter Representative or returning parts to Beckman Coulter for repair Beckman Coulter will NOT accept any items which have not been decontaminated where it is appropriate to do so If any parts are returned they must be enclosed in a sealed plastic bag stating that the contents are safe to handle and are not contaminated X PN B28615AB Safety Notice RoHS Notice ROHS Notice These labels and materials declaration table the Table of Hazardous Substance s Name and Concentration are to meet People s Republic of China Electronic Industry Standard SJ T11364 2006 Marking for Control of Pollution Caused by Electronic Information Products requirements China RoHS Caution Label This label indicates that the electronic information product contains certain toxic or hazardous substances The center number indicates the number of calendar years the product can be in operation Upon the expiration of its Environmentally Friendly Useful Period EFUP date the product must be immediately recycled The circling arrows indicate the product is recyclable The date code on the label or product indicates the date of manufacture 50
32. ystem Tubing Rear Panel 21 Wash System Tubing Wash Tool Tube Assembly 22 Liquid Waste Tubing 23 Access Panel Side Removal 24 Accessing Disposal Accessory Bags 25 Integration Deck Door Opening 25 XV Tables A WOW N e Tables Space Required 8 Actual Dimensions 9 Weight Specifications 13 Environmental Specifications 13 Biomek 4000 Enclosure System Troubleshooting 26 xvi Using the Biomek 4000 Enclosure System e Introduction PN B28615AB This guide provides an overview of using your Biomek 4000 Laboratory Automation Workstation Enclosure System Specifically topics in this manual include the following Safety Considerations Best Practices When Automating With the Enclosure Weight and Space Requirements Powering On Off the Instrument Using the Main Door and Access Panels Maintenance Troubleshooting Purpose The Enclosure System is an optional accessory designed specifically for the Biomek 4000 Laboratory Automation Workstation The main purpose of the enclosure is to serve as a barrier helping to protect your samples from airborne particles while you run your assays Configuration and Installation The Enclosure System can either be installed on the base Biomek 4000 instrument or on the base instrument and optional Integration Deck The Enclosure System can be purchased with the initial system purchase or at a later date and must be installed by a Beckman
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