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TDM フェニトイン

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Contents

1. 1
2. 2 1 1 Buchthal F Lennox Buchthal M A Diphenylhydantoin Relation of anticonvulsant effect to concentration in serum in Woodbury D M Penry J K Schmidt K P eds Antiepileptic Drugs Raven Press New York pp 193 209 1972 CN oO _ 0 2 Finn A L Olanow C W Phenytoin Therapeutic 2 Re a use and serum concentration monitoring in Taylor W SZ NE Nn J Fin A L eds Individualizing Drug Therapy 3 Be A DM Wi 4 ractic p
3. 2 1 2 3 1 1 EDTA 15 30C 7 2 8C 4 20 3
4. 37C 37C 27L 270zL 270 100zL 70 I 37C 247 T II 700nm TDM i 10 20 g mL 6 14 g mL2 7
5. 6 7 PHT HBs HTV AIDS HCV PHT PHT 85 95
6. 1 1 0zg mL 1 0 065 0 205 2 0xg mL 25ug mL 1 60 95 80 120 10 1 3 7170S 0 7 40 g mL 1 N 65 r 0997 y 103x 006 2 N 98 r 0995 0 95x 0 16 6 1 HIV HBV HCV _ PHT 54mL x 1 OO a e 2 PHT PHT
7. 87 94 70 80 5 5 HPPH 3 HPPH 90 5 5
8. 9 2 4 2 1 IN 20mg dL 20mg d 500mg dL 50mg dL 2500 5 450U L g mL 0 A yn 500 560 3000 001 100 005 500 0 08 I 1000 006 2000 003 2000 001 2500 000 2000 002
9. 1000 002 1000 017 1000 000 5 p 5 500 246 HPPH 2000 002 4000 001 3000 004 1000 0 07 5000 001 500 010 RE 1000 001 1000 0 03 2000 0 00 2000 004 ee 2000 0 00 1000 0 04 1500 001 2000 0 02 7000 000 3 1 2 TDM i PHT PHT PHT
10. 200141 005 13A2X00197218105 2012 2 4 2009 1 3 30402000 TDIM 1 2 3 4 5
11. S Ferrendelli J A Inhibition of Ca transport 4 Drai Din dn Into rat brain SynaptosomeSs by Diphenylhyadantoin 09 a a DPH Pharmacol Exp Ther 185 272 275 1973 4 ai CC 0 7 Penry J K Newmark M E The use of anti epileptic gt 4 MA drugs Ann Of Intern Med 90 207 218 1979 NS 8 51 1 131 141 2004 4 0120 249 977 FAX 0120 247 477 9 x x 1 2 8C 2 19 sem 13 5
12. plcation of Drug Monitoring Vol 24 Gross 08 ER Townsend Frank Inc New York pp 63 85 1981 oe 3 Jusko W J Bioavailabiity and disposition kinetics of 5 phenytoin in man in Kellaway P Petersen I eds 3 a gt a se Quantitative Analytic Studies in Epilepsy Raven 1 01 P New Yark 115 196 1976 1 NN 0 Co IS 4 Kutt H Diphenylhydantoin Relation of plasma lev 121C 20 els to clinical control in Woodbury D M Penry J K a Schmidt K P eds Antiepileptic Drugs Raven 2 P New York pn 211 218 1981 01 Ne 1 oO SD 1 SW 9 5 Buchthal F Svensmark O Serum concentrations of 1 00 a diphenylhydantoin Phenytoin and phenobarbital and 3 5 gt 6 0 S their relation to therapeutic and toxic effects Psychiat B 7 I Neurol Neurochir 74 117 136 1971 He en 6 Sohn R

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